SEQUENCE LISTING


<110> Hyseq, Inc

<120>  NOVEL NUCLEIC ACIDS AND POLYPEPTIDES

<130>  21272-090

<140>  NOT YET ASSIGNED
<141>  2001-11-30

<150>  09/728,952
<151>  2000-11-30

<160>  186  

<170>  PatentIn version 3.0


      <210> 1
      <211> 1162
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(883)

      <400> 1
 cggccgggcc ggggccgggc cgtagcggcg gcgcctggat gcggacccgg ccgcggggag     60

 acgggcgccc gccccgaaac gactttcagt ccccgacgcg ccccgcccaa cccctacg      118                                                                 
 atg aag agg gcg tcc gct gga ggg agc cgg ctg ctg gca tgg gtg ctg      166
 Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu
   1               5                  10                  15

 tgg ctg cag gcc tgg cag gtg gca gcc cca tgc cca ggt gcc tgc gta      214
 Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val
              20                  25                  30

 tgc tac aat gag ccc aag gtg acg aca agc tgc ccc cag cag ggc ctg      262
 Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu
          35                  40                  45

 cag gct gtg ccc gtg ggc atc cct gct gcc agc cag cgc atc ttc ctg      310
 Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu
      50                  55                  60

 cac ggc aac cgc atc tcg cat gtg cca gct gcc agc ttc cgt gcc tgc      358
 His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys
  65                  70                  75                  80

 cgc aac ctc acc atc ctg tgg ctg cac tcg aat gtg ctg gcc cga att      406
 Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile
                  85                  90                  95

 gat gcg gct gcc ttc act ggc ctg gcc ctc ctg gag cag ctg gac ctc      454
 Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu
             100                 105                 110

 agc gat aat gca cag ctc cgg tct gtg gac cct gcc aca ttc cac ggc      502
 Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly
         115                 120                 125

 ctg ggc cgc cta cac acg ctg cac ctg gac cgc tgc ggc ctg cag gag      550
 Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu
     130                 135                 140

 ctg ggc ccg ggg ctg ttc cgc ggc ctg gct gcc ctg cag tac ctc tac      598
 Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
 145                 150                 155                 160

 ctg cag gac aac gcg ctg cag gca ctg cct gat gac acc ttc cgc gac      646
 Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp
                 165                 170                 175

 ctg ggc aac ctc aca cac ctc ttc ctg cac ggc aac cgc atc tcc agc      694
 Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser
             180                 185                 190

 gtg ccc gag cgc gcc ttc cgt ggg ctg cac agc ctc gac cgt ctc cta      742
 Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
         195                 200                 205

 ctg cac cag aac cgc gtg gcc cat gtg cac ccg cat gcc ttc cgt gac      790
 Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp
     210                 215                 220

 ctt ggc cgc ctc atg aca ctc tat ctg ttt gcc aac aat cta tca gcg      838
 Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala
 225                 230                 235                 240

 ctg ccc act gag gcc ctg gcc ccc tgc gtg ccc tgc agt acc tga ggc      886
 Leu Pro Thr Glu Ala Leu Ala Pro Cys Val Pro Cys Ser Thr 
                 245                 250

 tcaacgacaa cccctgggtg tgtgactgcc gggcacgccc actctgggcc tggctgcaga    946

 agttccgcgg ctcctcctcc gaggtgccct gcagcctccc gcaacgcctg gctggccgtg   1006

 acctcaaacg cctagctgcc aatgacctgc agggctgcgc tgtggccacc ggccttacca   1066

 tcccatctgg accggcaggc aaccgatgag gagccgctgg ggcttcccaa gtgctgccac   1126

 cagatgccgc tgacaaggcc tcagtactgg agcctg                             1162




      <210> 2
      <211> 1289
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(1106)

      <400> 2
 gcacgagccg gaaaggaggc ccaaagcgcg ggcggcgagg caag atg gcg gca acc      56
                                                  Met Ala Ala Thr
                                                    1

 aag agg aaa cgg cgt gga ggc ttt gca gtt cag gcg aag aag cca aaa      104
 Lys Arg Lys Arg Arg Gly Gly Phe Ala Val Gln Ala Lys Lys Pro Lys
   5                  10                  15                  20

 aga aac gaa ata gat gcg gag ccg cca gct aag cgg cac gcc aca gca      152
 Arg Asn Glu Ile Asp Ala Glu Pro Pro Ala Lys Arg His Ala Thr Ala
                  25                  30                  35

 gag gag gtg gag gaa gaa gag agg gac cgg atc cca ggc ccc gtt tgc      200
 Glu Glu Val Glu Glu Glu Glu Arg Asp Arg Ile Pro Gly Pro Val Cys
              40                  45                  50

 aag gga aag tgg aaa aat aag gaa cgg att ctc atc ttt tct tcc aga      248
 Lys Gly Lys Trp Lys Asn Lys Glu Arg Ile Leu Ile Phe Ser Ser Arg
          55                  60                  65

 gga ata aat ttt aga aca aga cat tta atg cag gac ttg aga atg ttg      296
 Gly Ile Asn Phe Arg Thr Arg His Leu Met Gln Asp Leu Arg Met Leu
      70                  75                  80

 atg cct cat tct aaa gca gat act aaa atg gat cgt aag gat aag cta      344
 Met Pro His Ser Lys Ala Asp Thr Lys Met Asp Arg Lys Asp Lys Leu
  85                  90                  95                 100

 ttt gtg att aac gag gtt tgt gaa atg aag aac tgt aat aaa tgc atc      392
 Phe Val Ile Asn Glu Val Cys Glu Met Lys Asn Cys Asn Lys Cys Ile
                 105                 110                 115

 tat ttt gaa gct aag aaa aaa cag gat ctc tat atg tgg ctt tca aat      440
 Tyr Phe Glu Ala Lys Lys Lys Gln Asp Leu Tyr Met Trp Leu Ser Asn
             120                 125                 130

 tca cct cac gga cca tct gct aaa ttc ctt gtt caa aat att cat acc      488
 Ser Pro His Gly Pro Ser Ala Lys Phe Leu Val Gln Asn Ile His Thr
         135                 140                 145

 ctc gct gaa ctg aag atg act gga aac tgt ttg aaa ggt tct cgg ccc      536
 Leu Ala Glu Leu Lys Met Thr Gly Asn Cys Leu Lys Gly Ser Arg Pro
     150                 155                 160

 ctt ttg tct ttt gac cct gct ttt gat gaa tta cca cat tat gct ttg      584
 Leu Leu Ser Phe Asp Pro Ala Phe Asp Glu Leu Pro His Tyr Ala Leu
 165                 170                 175                 180

 tta aaa gaa ctc tta att cag atc ttt agt aca cca cgg tat cat ccc      632
 Leu Lys Glu Leu Leu Ile Gln Ile Phe Ser Thr Pro Arg Tyr His Pro
                 185                 190                 195

 aaa agc caa cca ttt gtg gac cac gtg ttt act ttc acc att ttg gat      680
 Lys Ser Gln Pro Phe Val Asp His Val Phe Thr Phe Thr Ile Leu Asp
             200                 205                 210

 aat agg ata tgg ttt cgg aac ttt cag atc ata gaa gaa gat gct gct      728
 Asn Arg Ile Trp Phe Arg Asn Phe Gln Ile Ile Glu Glu Asp Ala Ala
         215                 220                 225

 ctt gta gaa ata gga cct cgt ttt gtc tta aat ctc ata aag att ttc      776
 Leu Val Glu Ile Gly Pro Arg Phe Val Leu Asn Leu Ile Lys Ile Phe
     230                 235                 240

 cag gga agt ttt gga gga cca act tta tat gaa aat cct cac tac cag      824
 Gln Gly Ser Phe Gly Gly Pro Thr Leu Tyr Glu Asn Pro His Tyr Gln
 245                 250                 255                 260

 tca cca aac atg cat cgg cgt gtc ata aga tcc atc aca gct gca aaa      872
 Ser Pro Asn Met His Arg Arg Val Ile Arg Ser Ile Thr Ala Ala Lys
                 265                 270                 275

 tac aga gag aaa cag caa gtg aaa gat gtg caa aaa ctg aga aag aaa      920
 Tyr Arg Glu Lys Gln Gln Val Lys Asp Val Gln Lys Leu Arg Lys Lys
             280                 285                 290

 gag ccg aag act ctt ctt cca cat gat ccc act gca gat gtt ttt gta      968
 Glu Pro Lys Thr Leu Leu Pro His Asp Pro Thr Ala Asp Val Phe Val
         295                 300                 305

 aca cca gct gag gag aaa cca ata gaa ata cag tgg gta aaa cca gag     1016
 Thr Pro Ala Glu Glu Lys Pro Ile Glu Ile Gln Trp Val Lys Pro Glu
     310                 315                 320

 cca aaa gtt gat ttg aaa gca aga aag aaa cgg att tac aaa agg caa     1064
 Pro Lys Val Asp Leu Lys Ala Arg Lys Lys Arg Ile Tyr Lys Arg Gln
 325                 330                 335                 340

 aga aaa atg aaa cag agg atg gac agt ggg aaa aca aaa taa gtcaatg     1113
 Arg Lys Met Lys Gln Arg Met Asp Ser Gly Lys Thr Lys 
                 345                 350

 gaaacctgat ttgtttttca gttactttat atttattttg tattcaatgt gtaaatactt   1173

 ttattatcta atactatctt acgtctaatt agtgtagcat ttacaagaaa gaaaaattaa   1233

 gatcttaaaa tcagtgatta tctttttcta aataaaatat caccagaaaa aaaaaa       1289




      <210> 3
      <211> 1284
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(1284)

      <400> 3
 actcacaaga gagcagagga gccccaagtc ttggggacca cagaagatgc c atg tgc      57
                                                          Met Cys
                                                            1

 tcc acg atg tcg gcc ccc acc tgc ctg gcc cac ttg cct ccc tgc ttc      105
 Ser Thr Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro Cys Phe
           5                  10                  15

 ctg ctg ctg gca ctg gtc ctt gtc ccc tca gat gcc tct ggg cag agc      153
 Leu Leu Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly Gln Ser
      20                  25                  30

 agc agg aat gac tgg cag gtg cta cag ccc gag ggc ccc atg ctg gtg      201
 Ser Arg Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met Leu Val
  35                  40                  45                  50

 gca gaa ggt gag aca ctt cta ctg agg tgt atg gtg gtc ggc tcc tgc      249
 Ala Glu Gly Glu Thr Leu Leu Leu Arg Cys Met Val Val Gly Ser Cys
                  55                  60                  65

 act gat ggt atg ata aaa tgg gtg aag atc gcg cta gcg agc ttt tat      297
 Thr Asp Gly Met Ile Lys Trp Val Lys Ile Ala Leu Ala Ser Phe Tyr
              70                  75                  80

 gag gac gga ggg gat gaa gac att gtg acc att tcg cag gca acc ccc      345
 Glu Asp Gly Gly Asp Glu Asp Ile Val Thr Ile Ser Gln Ala Thr Pro
          85                  90                  95

 agt tca gtg tcc aga ggc aca gcc ccc agt gat aat aga gtg aca tcc      393
 Ser Ser Val Ser Arg Gly Thr Ala Pro Ser Asp Asn Arg Val Thr Ser
     100                 105                 110

 ttc aga gac ctc att cat gac caa gat gaa gat gag gag gaa gag gaa      441
 Phe Arg Asp Leu Ile His Asp Gln Asp Glu Asp Glu Glu Glu Glu Glu
 115                 120                 125                 130

 ggc cag agg ttt tat gct ggg ggc tca gag aga agt gga cag cag att      489
 Gly Gln Arg Phe Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln Gln Ile
                 135                 140                 145

 gtt ggc cct ccc agg aag aaa agt ccc aac gag ctg gtg gat gat ctc      537
 Val Gly Pro Pro Arg Lys Lys Ser Pro Asn Glu Leu Val Asp Asp Leu
             150                 155                 160

 ttt aaa ggt gcc aaa gag cat gga gct gta gct gtg gag cga gtg acc      585
 Phe Lys Gly Ala Lys Glu His Gly Ala Val Ala Val Glu Arg Val Thr
         165                 170                 175

 aag agc cct gga gag acc agt aaa ccg aga cca ttt gca gga ggt ggc      633
 Lys Ser Pro Gly Glu Thr Ser Lys Pro Arg Pro Phe Ala Gly Gly Gly
     180                 185                 190

 tac cgc ctt ggg gca gca cca gag gaa gag tct gcc tat gtg gca gga      681
 Tyr Arg Leu Gly Ala Ala Pro Glu Glu Glu Ser Ala Tyr Val Ala Gly
 195                 200                 205                 210

 gaa aag agg cag cat tcc agc caa gat gtt cat gta gta ttg aaa ctc      729
 Glu Lys Arg Gln His Ser Ser Gln Asp Val His Val Val Leu Lys Leu
                 215                 220                 225

 tgg aag agt gga ttc agc ctg gat aat gga gaa ctc aga agc tac caa      777
 Trp Lys Ser Gly Phe Ser Leu Asp Asn Gly Glu Leu Arg Ser Tyr Gln
             230                 235                 240

 gac cca tcc aat gcc cag ttt ctg gag tct atc cgc aga ggg gag gtg      825
 Asp Pro Ser Asn Ala Gln Phe Leu Glu Ser Ile Arg Arg Gly Glu Val
         245                 250                 255

 cca gca gag ctt cgg agg cta gct cac ggt gga cag gtg aac ttg gat      873
 Pro Ala Glu Leu Arg Arg Leu Ala His Gly Gly Gln Val Asn Leu Asp
     260                 265                 270

 atg gag gac cat cgg gac gag gac ttt gtg aag ccc aaa gga gcc ctt      921
 Met Glu Asp His Arg Asp Glu Asp Phe Val Lys Pro Lys Gly Ala Leu
 275                 280                 285                 290

 caa gcc ttc act ggc gag ggt cag aaa ctg ggc agc act gcc ccc cag      969
 Gln Ala Phe Thr Gly Glu Gly Gln Lys Leu Gly Ser Thr Ala Pro Gln
                 295                 300                 305

 gtg ttg agt acc agc tct cca gcc caa cag gca gaa aat gaa gcc aaa     1017
 Val Leu Ser Thr Ser Ser Pro Ala Gln Gln Ala Glu Asn Glu Ala Lys
             310                 315                 320

 gcc agc tct tcc atc tta atc aac gaa tca gag cct acc aca aac atc     1065
 Ala Ser Ser Ser Ile Leu Ile Asn Glu Ser Glu Pro Thr Thr Asn Ile
         325                 330                 335

 caa att cgg ctt gca gac ggc ggg agg ctg gtg cag aaa ttt aac cac     1113
 Gln Ile Arg Leu Ala Asp Gly Gly Arg Leu Val Gln Lys Phe Asn His
     340                 345                 350

 agc cac agg atc agc gac atc cga ctc ttc atc gtg gat gcc cgg cca     1161
 Ser His Arg Ile Ser Asp Ile Arg Leu Phe Ile Val Asp Ala Arg Pro
 355                 360                 365                 370

 gcc atg gct gcc acc agc ttt atc ctc atg act act ttc ccg aac aaa     1209
 Ala Met Ala Ala Thr Ser Phe Ile Leu Met Thr Thr Phe Pro Asn Lys
                 375                 380                 385

 gag ctg gct gat gag agc cag acc ctg aag gaa gcc aac ctg ctc aat     1257
 Glu Leu Ala Asp Glu Ser Gln Thr Leu Lys Glu Ala Asn Leu Leu Asn
             390                 395                 400

 gct gtc atc gtg cag cgg tta aca taa                                 1284
 Ala Val Ile Val Gln Arg Leu Thr 
         405                 410





      <210> 4
      <211> 1364
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(1177)

      <400> 4
 agaggagccc caagtcttgg ggaccacaga agatgcc atg tgc tcc acg atg tcg      55
                                          Met Cys Ser Thr Met Ser
                                            1               5

 gcc ccc acc tgc ctg gcc cac ttg cct ccc tgc ttc ctg ctg ctg gca      103
 Ala Pro Thr Cys Leu Ala His Leu Pro Pro Cys Phe Leu Leu Leu Ala
              10                  15                  20

 ctg gtc ctt gtc ccc tca gat gcc tct ggg cag agc agc agg aat gac      151
 Leu Val Leu Val Pro Ser Asp Ala Ser Gly Gln Ser Ser Arg Asn Asp
          25                  30                  35

 tgg cag gtg cta cag ccc gag ggc ccc atg ctg gtg gca gaa ggt gag      199
 Trp Gln Val Leu Gln Pro Glu Gly Pro Met Leu Val Ala Glu Gly Glu
      40                  45                  50

 aca ctt cta ctg agg tgt atg gtg gtc ggc tcc tgc act gat ggt atg      247
 Thr Leu Leu Leu Arg Cys Met Val Val Gly Ser Cys Thr Asp Gly Met
  55                  60                  65                  70

 ata aaa tgg gtg aag atc gcg cta gcg agc ttt tat gag gac gga ggg      295
 Ile Lys Trp Val Lys Ile Ala Leu Ala Ser Phe Tyr Glu Asp Gly Gly
                  75                  80                  85

 gat gaa gac att gtg acc att tcg cag gca acc ccc agt tca gtg tcc      343
 Asp Glu Asp Ile Val Thr Ile Ser Gln Ala Thr Pro Ser Ser Val Ser
              90                  95                 100

 aga ggc aca gcc ccc agt gat aat aga gtg aca tcc ttc aga gac ctc      391
 Arg Gly Thr Ala Pro Ser Asp Asn Arg Val Thr Ser Phe Arg Asp Leu
         105                 110                 115

 att cat gac caa gat gaa gat gag gag gaa gag gaa ggc cag agg ttt      439
 Ile His Asp Gln Asp Glu Asp Glu Glu Glu Glu Glu Gly Gln Arg Phe
     120                 125                 130

 tat gct ggg ggc tca gag aga agt gga cag cag att gtt ggc cct ccc      487
 Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln Gln Ile Val Gly Pro Pro
 135                 140                 145                 150

 agg aag aaa agt ccc aac gag ctg gtg gat gat ctc ttt aaa ggt gcc      535
 Arg Lys Lys Ser Pro Asn Glu Leu Val Asp Asp Leu Phe Lys Gly Ala
                 155                 160                 165

 aaa gag cat gga gct gta gct gtg gag cga gtg acc aag agc cct gga      583
 Lys Glu His Gly Ala Val Ala Val Glu Arg Val Thr Lys Ser Pro Gly
             170                 175                 180

 gag acc agt aaa ccg aga gtt cat gta gta ttg aaa ctc tgg aag agt      631
 Glu Thr Ser Lys Pro Arg Val His Val Val Leu Lys Leu Trp Lys Ser
         185                 190                 195

 gga ttc agc ctg gat aat gga gaa ctc aga agc tac caa gac cca tcc      679
 Gly Phe Ser Leu Asp Asn Gly Glu Leu Arg Ser Tyr Gln Asp Pro Ser
     200                 205                 210

 aat gcc cag ttt ctg gag tct atc cgc aga ggg gag gtg cca gca gag      727
 Asn Ala Gln Phe Leu Glu Ser Ile Arg Arg Gly Glu Val Pro Ala Glu
 215                 220                 225                 230

 ctt cgg agg cta gct cac ggt gga cag gtg aac ttg gat atg gag gac      775
 Leu Arg Arg Leu Ala His Gly Gly Gln Val Asn Leu Asp Met Glu Asp
                 235                 240                 245

 cat cgg gac gag gac ttt gtg aag ccc aaa gga gcc ttc aaa gcc ttc      823
 His Arg Asp Glu Asp Phe Val Lys Pro Lys Gly Ala Phe Lys Ala Phe
             250                 255                 260

 act ggc gag ggt cag aaa ctg ggc agc act gcc ccc cag gtg ttg agt      871
 Thr Gly Glu Gly Gln Lys Leu Gly Ser Thr Ala Pro Gln Val Leu Ser
         265                 270                 275

 acc agc tct cca gcc caa cag gca gaa aat gaa gcc aaa gcc agc tct      919
 Thr Ser Ser Pro Ala Gln Gln Ala Glu Asn Glu Ala Lys Ala Ser Ser
     280                 285                 290

 tcc atc tta atc gac gaa tca gag cct acc aca aac atc caa att cgg      967
 Ser Ile Leu Ile Asp Glu Ser Glu Pro Thr Thr Asn Ile Gln Ile Arg
 295                 300                 305                 310

 ctt gca gac ggc ggg agg ctg gtg cag aaa ttt aac cac agc cac agg     1015
 Leu Ala Asp Gly Gly Arg Leu Val Gln Lys Phe Asn His Ser His Arg
                 315                 320                 325

 atc agc gac atc cga ctc ttc atc gtg gat gcc cgg cca gcc atg gct     1063
 Ile Ser Asp Ile Arg Leu Phe Ile Val Asp Ala Arg Pro Ala Met Ala
             330                 335                 340

 gcc acc agc ttt atc ctc atg act act ttc ccg aac aaa gag ctg gct     1111
 Ala Thr Ser Phe Ile Leu Met Thr Thr Phe Pro Asn Lys Glu Leu Ala
         345                 350                 355

 gat gag agc cag acc ctg aag gaa gcc aac ctg ctc aat gct gtc atc     1159
 Asp Glu Ser Gln Thr Leu Lys Glu Ala Asn Leu Leu Asn Ala Val Ile
     360                 365                 370

 gtg cag cgg tta aca taa ccgccc agccagctgc ctggcctccc tcctgtgttt     1213
 Val Gln Arg Leu Thr 
 375

 cccatggcca gtggccatgc cccatgggga tcgcccctcc tgcccccttg tgcacaccca   1273

 gcagtccagt gcaacgtctc ctccatagct ctgggttctt agatcttggt tggacgtttg   1333

 ttttctcctt agttgcattt cctgggtttt t                                  1364




      <210> 5
      <211> 1260
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(732)

      <400> 5
 aaggatcctt aattaaatta atcccccccc cccccccccc gctcatcggc tgggcctcgt     60

 cgaccggcaa gcggaacgcg gcagcggggc tgggcctgtg cggcggccgc cggagcgctt    120

 tggaaggcgc acggggcgaa g  atg gcg gcg gag cga cag gag gcg ctg agg     171
                          Met Ala Ala Glu Arg Gln Glu Ala Leu Arg
                            1               5                  10

 gag ttc gtg gcg gtg acg ggc gcc gag gag gac cgg gcc cgc ttc ttt      219
 Glu Phe Val Ala Val Thr Gly Ala Glu Glu Asp Arg Ala Arg Phe Phe
                  15                  20                  25

 ctc gag tcg gcc ggc tgg gac ttg cag atc gcg cta gcg agc ttt tat      267
 Leu Glu Ser Ala Gly Trp Asp Leu Gln Ile Ala Leu Ala Ser Phe Tyr
              30                  35                  40

 gag gac gga ggg gat gaa gac att gtg acc att tcg cag gca acc ccc      315
 Glu Asp Gly Gly Asp Glu Asp Ile Val Thr Ile Ser Gln Ala Thr Pro
          45                  50                  55

 agt tca gtg tcc aga ggc aca gcc ccc agt gat aat aga gtg aca tcc      363
 Ser Ser Val Ser Arg Gly Thr Ala Pro Ser Asp Asn Arg Val Thr Ser
      60                  65                  70

 ttc aga gac ctc att cat gac caa gat gaa gat gag gag gaa gag gaa      411
 Phe Arg Asp Leu Ile His Asp Gln Asp Glu Asp Glu Glu Glu Glu Glu
  75                  80                  85                  90

 ggc cag agg agc agg ttt tat gct ggg ggc tca gag aga agt gga cag      459
 Gly Gln Arg Ser Arg Phe Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln
                  95                 100                 105

 cag att gtt ggc cct ccc agg aag aaa agt ccc aac gag ctg gtg gat      507
 Gln Ile Val Gly Pro Pro Arg Lys Lys Ser Pro Asn Glu Leu Val Asp
             110                 115                 120

 gat ctc ttt aaa ggt gcc aaa gag cat gga gct gta gct gtg gag cga      555
 Asp Leu Phe Lys Gly Ala Lys Glu His Gly Ala Val Ala Val Glu Arg
         125                 130                 135

 gtg acc aag agc cct gga gag acc agt aaa ccg aga cca ttt gca gga      603
 Val Thr Lys Ser Pro Gly Glu Thr Ser Lys Pro Arg Pro Phe Ala Gly
     140                 145                 150

 ggt ggc tac cgc ctt ggg gcc agc acc aga gga aga gtc tgc cta tgt      651
 Gly Gly Tyr Arg Leu Gly Ala Ser Thr Arg Gly Arg Val Cys Leu Cys
 155                 160                 165                 170

 ggc agg aga aaa gag gca gca ttc cag cca aga tgt tca tgt agt att      699
 Gly Arg Arg Lys Glu Ala Ala Phe Gln Pro Arg Cys Ser Cys Ser Ile
                 175                 180                 185

 gaa act ctg gaa gag tgg att cag cct gga taa tggagaac tcagaagcta      750
 Glu Thr Leu Glu Glu Trp Ile Gln Pro Gly 
             190                 195

 ccaagaccca tccaatgccc agtttctgga gtctattcgc agaggggagg tgcagcagag    810

 cttccgaggc tagcctcacg tggacaggtg aacttggata tggaggacca tcgggacgag    870

 gactttgtga agcccaaagg agccttcaaa gccttcactg gcgagggtca gaaactgggc    930

 agcactgccc cccaggtgtt gagtaccagc tctccagccc aacaggcaga aaatgaagcc    990

 aaagccagct cttccatctt aatcgacgaa tcagagccta ccacaaacat ccaaattcgg   1050

 cttgcagacg gcgggaggct ggtgcagaaa tttaaccaca gccacaggat cagcgacatc   1110

 cgactcttca tcgtggatgc ccggccagcc atggctgcca ccagctttat cctcatgact   1170

 actttcccga acaaagagct ggctgatgag agccagaccc tgaaggaagc caacctgctc   1230

 aatgctgtca tcgtgcagcg gttaacataa                                    1260




      <210> 6
      <211> 473
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(358)

      <220>
      <221> misc_feature
      <222> (1)...(473)
      <223> n = a,t,c or g

      <400> 6
 tctgccagct acccgcgctc tgagcccggg gccagattcc catggaagcg ccgcg atg      58
                                                              Met
                                                                1

 ttc gcc ccc cgg ctg ctg gat ttg cag aag acg aaa tac gcg agg ttc      106
 Phe Ala Pro Arg Leu Leu Asp Leu Gln Lys Thr Lys Tyr Ala Arg Phe
               5                  10                  15

 atg aac cac cga gtc cct gcc cac aag agg tac cag ccc aca gag tat      154
 Met Asn His Arg Val Pro Ala His Lys Arg Tyr Gln Pro Thr Glu Tyr
          20                  25                  30

 gaa cat gcg gcc aac tgt gcc acc cat gct ttc tgg atc atc ccc agc      202
 Glu His Ala Ala Asn Cys Ala Thr His Ala Phe Trp Ile Ile Pro Ser
      35                  40                  45

 atc ctg ggc agc tcc aac ctc tac ttc ctg tcg gac gat gac tgg gag      250
 Ile Leu Gly Ser Ser Asn Leu Tyr Phe Leu Ser Asp Asp Asp Trp Glu
  50                  55                  60                  65

 acc atc tct gcc tgg atc tac ggc ctc ggc ctc tgc ggc ctc ttc gtg      298
 Thr Ile Ser Ala Trp Ile Tyr Gly Leu Gly Leu Cys Gly Leu Phe Val
                  70                  75                  80

 gtg tcc act gtg ttt cac acc atc tcc tgg aag aag agc cac ctc aga      346
 Val Ser Thr Val Phe His Thr Ile Ser Trp Lys Lys Ser His Leu Arg
              85                  90                  95

 tgg gga ttc tga ggg ccaaggggtc ttggctggac agaggagccc agccctgcta      401
 Trp Gly Phe 
         100

 acctgtaggc aggcacgatc agtccagggc acggctctgn gggcactggc ccttccttgc    461

 ttgcaggggc tg                                                        473




      <210> 7
      <211> 2432
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(1890)

      <400> 7
 gccgcgaatt cggcacgagc ctgtgggagg ctgttttctg agggagctga gtgtttacag     60

 ccactcagcc ctgctctgct cagctgaagc agaaaacaga gaccttttgc attactttgg    120

 ttcaagagca agacaggagg cgactgc    atg aga cca tgg ctg aga cac cta     171
                                  Met Arg Pro Trp Leu Arg His Leu
                                    1               5

 gtc ctc cag gca ctg agg aac tcc agg gca ttc tgt ggg tct cat ggg      219
 Val Leu Gln Ala Leu Arg Asn Ser Arg Ala Phe Cys Gly Ser His Gly
      10                  15                  20

 aag cca gca cct cta cct gtt cct cag aag atc gtg gcc acc tgg gaa      267
 Lys Pro Ala Pro Leu Pro Val Pro Gln Lys Ile Val Ala Thr Trp Glu
  25                  30                  35                  40

 gcc atc agc ctg gga agg cag ctg gtg cct gag tac ttc aac ttc gcc      315
 Ala Ile Ser Leu Gly Arg Gln Leu Val Pro Glu Tyr Phe Asn Phe Ala
                  45                  50                  55

 cat gat gtg ctg gat gtg tgg agt cgg ctg gaa gag gct gga cac cgc      363
 His Asp Val Leu Asp Val Trp Ser Arg Leu Glu Glu Ala Gly His Arg
              60                  65                  70

 ccc cca aat cct gcc ttc tgg tgg gtc aat ggc aca gga gca gag atc      411
 Pro Pro Asn Pro Ala Phe Trp Trp Val Asn Gly Thr Gly Ala Glu Ile
          75                  80                  85

 aag tgg agc ttt gag gag ctg ggg aag cag tcc agg aag gca gcc aat      459
 Lys Trp Ser Phe Glu Glu Leu Gly Lys Gln Ser Arg Lys Ala Ala Asn
      90                  95                 100

 gtg ctg ggg ggt gca tgc ggc ctg cag cct ggg gac aga atg atg ctg      507
 Val Leu Gly Gly Ala Cys Gly Leu Gln Pro Gly Asp Arg Met Met Leu
 105                 110                 115                 120

 gta ctc cca cgg ctc ccg gag tgg tgg ctg gtc agt gtg gct tgc atg      555
 Val Leu Pro Arg Leu Pro Glu Trp Trp Leu Val Ser Val Ala Cys Met
                 125                 130                 135

 cgg aca ggg act gtg atg att ccg ggt gtg act cag ctg aca gag aag      603
 Arg Thr Gly Thr Val Met Ile Pro Gly Val Thr Gln Leu Thr Glu Lys
             140                 145                 150

 gac ctc aag tac cgg ctg cag gcg tcc agg gcc aag tcc att atc acc      651
 Asp Leu Lys Tyr Arg Leu Gln Ala Ser Arg Ala Lys Ser Ile Ile Thr
         155                 160                 165

 agt gac tcc cta gct cca agg gtg gat gcc atc agt gcc gaa tgc ccc      699
 Ser Asp Ser Leu Ala Pro Arg Val Asp Ala Ile Ser Ala Glu Cys Pro
     170                 175                 180

 tcc ctc cag acc aag ctg ctg gtg tca gac agc agt cgg cca ggc tgg      747
 Ser Leu Gln Thr Lys Leu Leu Val Ser Asp Ser Ser Arg Pro Gly Trp
 185                 190                 195                 200

 ttg aac ttc agg gaa ctc ctc cgg gag gct tct aca gag cac aac tgc      795
 Leu Asn Phe Arg Glu Leu Leu Arg Glu Ala Ser Thr Glu His Asn Cys
                 205                 210                 215

 atg agg aca aag agt cga gac ccg ctg gcc atc tac ttt acc aag cgg      843
 Met Arg Thr Lys Ser Arg Asp Pro Leu Ala Ile Tyr Phe Thr Lys Arg
             220                 225                 230

 gaa cca ccg ggg gcc ccc aag atg gtc gag cac tcc cag agc agc tac      891
 Glu Pro Pro Gly Ala Pro Lys Met Val Glu His Ser Gln Ser Ser Tyr
         235                 240                 245

 gga ctg ggt ttt gtg gcc agc gga aga cgg tgg gtg gcc ttg acc gaa      939
 Gly Leu Gly Phe Val Ala Ser Gly Arg Arg Trp Val Ala Leu Thr Glu
     250                 255                 260

 tct gac atc ttc tgg aac acg act gac act ggc tgg gtg aag gca gcc      987
 Ser Asp Ile Phe Trp Asn Thr Thr Asp Thr Gly Trp Val Lys Ala Ala
 265                 270                 275                 280

 tgg act ctc ttc tct gcc tgg cct aat gga tct tgc att ttt gtg cat     1035
 Trp Thr Leu Phe Ser Ala Trp Pro Asn Gly Ser Cys Ile Phe Val His
                 285                 290                 295

 gag ctg ccc cga gtt gat gcc aaa gtt atc ctg aat act ctc tcc aaa     1083
 Glu Leu Pro Arg Val Asp Ala Lys Val Ile Leu Asn Thr Leu Ser Lys
             300                 305                 310

 ttc ccg ata acc acc ctc tgc tgt gtc cca acc atc ttt cgg ctg ctt     1131
 Phe Pro Ile Thr Thr Leu Cys Cys Val Pro Thr Ile Phe Arg Leu Leu
         315                 320                 325

 gtg cag gag gat ctg acc agg tac cag ttt cag agc ttg agg cac tgt     1179
 Val Gln Glu Asp Leu Thr Arg Tyr Gln Phe Gln Ser Leu Arg His Cys
     330                 335                 340

 ctg acc gga gga gag gcc ctc aac cct gac gtg agg gag aag tgg aaa     1227
 Leu Thr Gly Gly Glu Ala Leu Asn Pro Asp Val Arg Glu Lys Trp Lys
 345                 350                 355                 360

 cac cag act ggt gtg gag ctg tac gaa ggc tat ggc cag tct gaa acg     1275
 His Gln Thr Gly Val Glu Leu Tyr Glu Gly Tyr Gly Gln Ser Glu Thr
                 365                 370                 375

 gtt gtc atc tgt gcc aat cca aaa ggc atg aaa atc aag tct gga tcc     1323
 Val Val Ile Cys Ala Asn Pro Lys Gly Met Lys Ile Lys Ser Gly Ser
             380                 385                 390

 atg ggg aag gcg tcc cca ccc tac gat gtg cag att gtg gat gat gag     1371
 Met Gly Lys Ala Ser Pro Pro Tyr Asp Val Gln Ile Val Asp Asp Glu
         395                 400                 405

 ggc aac gtc ctg cct cct gga gaa gag ggg aat gtt gcc gtc cgt atc     1419
 Gly Asn Val Leu Pro Pro Gly Glu Glu Gly Asn Val Ala Val Arg Ile
     410                 415                 420

 aga ccc act cgg ccc ttc tgt ttc ttc aat tgc tat ttg gac aat cct     1467
 Arg Pro Thr Arg Pro Phe Cys Phe Phe Asn Cys Tyr Leu Asp Asn Pro
 425                 430                 435                 440

 gag aag aca gct gca tca gaa caa ggg gac ttt tac atc aca ggg gac     1515
 Glu Lys Thr Ala Ala Ser Glu Gln Gly Asp Phe Tyr Ile Thr Gly Asp
                 445                 450                 455

 cga gct cgc atg gac aag gat ggc tac ttt tgg ttc atg gga aga aac     1563
 Arg Ala Arg Met Asp Lys Asp Gly Tyr Phe Trp Phe Met Gly Arg Asn
             460                 465                 470

 gac gat gtg atc aat tct tca agc tac cgg atc ggg cct gtt gaa gtg     1611
 Asp Asp Val Ile Asn Ser Ser Ser Tyr Arg Ile Gly Pro Val Glu Val
         475                 480                 485

 gaa agt gcc ctg gca gag cat cct gct gtc ctg gag tcg gct gtg gtc     1659
 Glu Ser Ala Leu Ala Glu His Pro Ala Val Leu Glu Ser Ala Val Val
     490                 495                 500

 agc agc cca gac ccc atc agg gga gag gtg gta aag gca ttt ata gtc     1707
 Ser Ser Pro Asp Pro Ile Arg Gly Glu Val Val Lys Ala Phe Ile Val
 505                 510                 515                 520

 ctt act cca gcc tac tcc tct cat gac cca gag gca cta acg cgg gaa     1755
 Leu Thr Pro Ala Tyr Ser Ser His Asp Pro Glu Ala Leu Thr Arg Glu
                 525                 530                 535

 ctc cag gag cat gtg aaa agg gtg act gct cca tac aaa tac ccc agg     1803
 Leu Gln Glu His Val Lys Arg Val Thr Ala Pro Tyr Lys Tyr Pro Arg
             540                 545                 550

 aag gtg gcc ttt gtt tca gaa ctg cca aag acg gtt tct gga aag atc     1851
 Lys Val Ala Phe Val Ser Glu Leu Pro Lys Thr Val Ser Gly Lys Ile
         555                 560                 565

 caa agg agt aaa ttg cga agt cag gag tgg ggg aaa tga ggtgcacccc      1900
 Gln Arg Ser Lys Leu Arg Ser Gln Glu Trp Gly Lys 
     570                 575                 580

 aggaaggccc cgtagacctc cgaagactcc acaagaaact aatggatcac tggtcagtcc   1960

 ccatggggag catcatctct tcgaccctaa agatgtcaaa ggtgtgcagc ttccaaacgg   2020

 catccccagg atcactgggc aatgctggaa agagcaaaag aatatcattg gccctgatca   2080

 catagatgct gcgccgccta gcaaatgctt ggtggttcga cttctccctc tgtctggggg   2140

 caggctcagc atctgcccac tggtctcact aagagctttc agatttccct ccataggaca   2200

 ggttaccata gacttggggc acttgtgggt actcattttc tgccagtggg aatgtaaagg   2260

 cttcatcctt tgtatgtaac catttggcaa aagtatgcag gaacataaaa taaaatatcc   2320

 tttagctcag aaattctatc ttcgggagtc accacaaaag aaaaaaatca aaatgcagaa   2380

 aatgtgtggt gcactaagat gatcacacag cattaaaact aaaaaaaaaa aa           2432




      <210> 8
      <211> 783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(379)

      <400> 8
 cgccccccgc cgccgctgca caccggaccc agccgccgtg ccgcgggcc    atg gac      55
                                                          Met Asp
                                                            1

 ctg ccc agg ggc ctg gtg gtg gcc tgg gcg ctc agc ctg tgg cca ggg      103
 Leu Pro Arg Gly Leu Val Val Ala Trp Ala Leu Ser Leu Trp Pro Gly
           5                  10                  15

 ttc acg gac acc ttc aac atg gac acc agg aag ccc cgg gtc atc cct      151
 Phe Thr Asp Thr Phe Asn Met Asp Thr Arg Lys Pro Arg Val Ile Pro
      20                  25                  30

 ggc tcc agg acc gcc ttc ttt ggc tac aca gtg cag cag cac gac atc      199
 Gly Ser Arg Thr Ala Phe Phe Gly Tyr Thr Val Gln Gln His Asp Ile
  35                  40                  45                  50

 agt ggc aat aag tgg ctg gtc gtg ggc gcc cca ctg gaa acc aat ggc      247
 Ser Gly Asn Lys Trp Leu Val Val Gly Ala Pro Leu Glu Thr Asn Gly
                  55                  60                  65

 tac cag aag acg gga gac gtg tac aag tgt cca gtg atc cac ggg aac      295
 Tyr Gln Lys Thr Gly Asp Val Tyr Lys Cys Pro Val Ile His Gly Asn
              70                  75                  80

 tgc acc aaa ctc aac ctg ggt aac gtg ggc tgg tgg tct ctt cac aat      343
 Cys Thr Lys Leu Asn Leu Gly Asn Val Gly Trp Trp Ser Leu His Asn
          85                  90                  95

 gag gcc agc ggt tgt cta aca caa ggc agg ctc tga tgca cgcccatgtc      393
 Glu Ala Ser Gly Cys Leu Thr Gln Gly Arg Leu 
     100                 105

 catggtcaca ctgactcctt cctgctactc catgagatga cccagctgat atcactgccc    453

 ccactttaca catgaggaag ctgaggccag ggagaggagg caacttttcc acagtcacac    513

 agcttgccag gggctcacca ggaatcaacc caggccctag ctgtcccaga ccattcctct    573

 ttctgactca gccactgccc ttcaactcaa agttttctct cccaggagaa aaaaccaaac    633

 caaagggggc ggccgtttta gaggatccag gtttacttcc cccggcatgc aacgcaataa    693

 tcttttttat aggggccccc aaaattccat tcccgtgggc cggcggtttt tacaacctcc    753

 ggggaagtgg gaaaacacct tgggggttcc                                     783




      <210> 9
      <211> 1830
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (461)..(931)

      <400> 9
 ttttttgaaa ctcaatttcc cgatcggaaa atagagtccc gtttcccagg gtcattctga     60

 aaattggatg tccacgtttc ctcagcaaag agcttcacat aaagtaggtg atcaggactg    120

 ggcatggtgg ctcacgcctg taatcccaac actttgggag gtcgaggtga gagaatggct    180

 tgaagcctcc cggcctcaag accagcttcg acaacataat gagaaccccc ccaaccccca    240

 ctcccccatc tctacaaaaa ataaaaataa agtaggtgat caataagatg gcagatgaga    300

 aaactgggcc agatgacaca aagagagggc aggttaaggt gggtgggccc agctctgggt    360

 gacaaggcgg gcgtccctgt ttctagacaa aacccactgg ccagtggatg agcagaatct    420

 gggctccctg tacaccattg aggccacagc ctatgggctc  atg cag aag ctg gag     475
                                              Met Gln Lys Leu Glu
                                                1               5

 ctg ggc cgg tac aat gag aca cac gcc ata gcc aag tgg cta cta gag      523
 Leu Gly Arg Tyr Asn Glu Thr His Ala Ile Ala Lys Trp Leu Leu Glu
                  10                  15                  20

 aag cag gag ctg gga gga ggc ttc agg tcc acc cag acc acg gtg gtg      571
 Lys Gln Glu Leu Gly Gly Gly Phe Arg Ser Thr Gln Thr Thr Val Val
              25                  30                  35

 gcc ctt gaa gct ctg acc cgc ttc cgc gaa gct gtc ccc ttc aag ggc      619
 Ala Leu Glu Ala Leu Thr Arg Phe Arg Glu Ala Val Pro Phe Lys Gly
          40                  45                  50

 atc cag gat ctc cac gtc cag atc aga gcc ccc aag aca gcc ctg aat      667
 Ile Gln Asp Leu His Val Gln Ile Arg Ala Pro Lys Thr Ala Leu Asn
      55                  60                  65

 gtg aat tgg tac att gat cac agc aat gcc tac caa cag cgg tca gca      715
 Val Asn Trp Tyr Ile Asp His Ser Asn Ala Tyr Gln Gln Arg Ser Ala
  70                  75                  80                  85

 aag ttc ctt gcc cag gac gac cta gag atc aaa gcc agt ggc aac ggg      763
 Lys Phe Leu Ala Gln Asp Asp Leu Glu Ile Lys Ala Ser Gly Asn Gly
                  90                  95                 100

 aga ggc acc atc tcg atc ctg aca atg tat cac aag tcc cca gag tcc      811
 Arg Gly Thr Ile Ser Ile Leu Thr Met Tyr His Lys Ser Pro Glu Ser
             105                 110                 115

 cgg gag gac aac tgc aac ctg tac cac ctg aat gcg act ctc cac agt      859
 Arg Glu Asp Asn Cys Asn Leu Tyr His Leu Asn Ala Thr Leu His Ser
         120                 125                 130

 gcc cta gaa gaa aat aaa aag gga ggt gag act ttt cgg ctc cgg atg      907
 Ala Leu Glu Glu Asn Lys Lys Gly Gly Glu Thr Phe Arg Leu Arg Met
     135                 140                 145

 gaa aca agg ttc cag aac aat tga gaggccacaa tgactatcat ggaggtctcc     961
 Glu Thr Arg Phe Gln Asn Asn 
 150                 155

 ctgctcacgg gcttctaccc caaccaggat gacctcaaac agctcacgag tgatgtggag   1021

 aggtacgcct ttcagtacaa aaccaagaca agtaccagcg acagcactgt tgtcctctac   1081

 ctggaaaagc tctcccatga gaagaacacg gtgctgggct ttcgggttca caggatgctg   1141

 caggcggagt tcctgcaggc cgccctggtc accatctacg actactacga gccttcccgg   1201

 aggtgcagca ctttctacaa cctgcccaca gagcaatctt ccctgagaaa gatctgccac   1261

 aaagacatct gcagatgtgc agagggacag tgcccatccc tgcagaagcc cagtggccaa   1321

 ttgaggcagg aggagctcca gacaacagca tgtgaggcag gcgtggattt tgtgtacaag   1381

 acaaagctgg aatctgtgga ggtctctgcc tccaaccctt acgtctatta caacacgcag   1441

 ctcgaagaca tcattaagag tggtacggac cctgccacac ccctggccat gaagaaattc   1501

 gtctcccatg ccacttgcca tgactccctg gggttgcaag aacaggaatc gtacctcatc   1561

 atgggccaga cgtcagacct gtggagaatc aaatctgatt acagctatgt tctgggcaag   1621

 gagacgttcc tcatcctttg gccagcagat ggagatgcca gcaagaaaga attgcgggac   1681

 caactggagg aatttttgga atatatgcgc acccacggct gccagtcctg agcctcttct   1741

 gctttcaggg aggtgtcatc aggcagctct gggccactgg gtttaacccc aaataaagag   1801

 cacaggatat gacacccaaa aaaaaaaaa                                     1830




      <210> 10
      <211> 885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (242)..(838)

      <400> 10
 tttcgtgccg ggtggttcct ctggagatta aatgtacttc acagaacctc agcgagcgga     60

 ctccagttat attccgtgct cttgtcggca cgcatttcac ttctaggact gggccggggt    120

 ctgcagggct cagctgagcc catgagctcc cagagctaac ccctgaacac ccaggcgggc    180

 aaagggctga tgtcggtagt ccccatcctg gaggggcagg ctctgcgcat ctgctcctgg    240

 c    atg gcg ctg cgg cac ctc gcc ctc ctg gct ggc ctt ctc gtg gga     286
      Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly
        1               5                  10                  15

 gtc gcc agc aag tcc atg gag aac acg gcc cag ctg ccc gag tgc tgt      334
 Val Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys
                  20                  25                  30

 gta gat gtg gtg ggc gtc aac gcc agc tgc cca ggc gca agt ctg tgt      382
 Val Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys
              35                  40                  45

 ggt cca ggc tgt tac agg cgc tgg aac gcg gac ggg agc gcc agc tgc      430
 Gly Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys
          50                  55                  60

 gtc cgc tgt ggg aac gga acc ctc cca gcc tac aac ggc tcc gag tgt      478
 Val Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys
      65                  70                  75

 aga agc ttt gct ggc ccg ggt gcg cca ttc ccc atg aac aga agc tca      526
 Arg Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser
  80                  85                  90                  95

 ggg acc ccc ggg cgg cca cat cct ggg gct ccg cgc gtg gcc gcc tcc      574
 Gly Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser
                 100                 105                 110

 ctc ttc ctg ggc acg ttc ttc att agc tcc ggc ctc atc ctc tcc gta      622
 Leu Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val
             115                 120                 125

 gct ggg ttc ttc tac ctc aag cgc tcc agt aaa ctc ccc agg gcc tgc      670
 Ala Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys
         130                 135                 140

 tac aga aga aac aaa gct ccg gcc ctg cag cct ggc gaa gcc gct gca      718
 Tyr Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala
     145                 150                 155

 atg atc ccc ccg cca cag tcc tca gta cgg aag ccg cgc tac gtc agg      766
 Met Ile Pro Pro Pro Gln Ser Ser Val Arg Lys Pro Arg Tyr Val Arg
 160                 165                 170                 175

 cgg gag cgg ccc ctg gac agg gcc acg gat ccc gct gcc ttc ccg ggg      814
 Arg Glu Arg Pro Leu Asp Arg Ala Thr Asp Pro Ala Ala Phe Pro Gly
                 180                 185                 190

 gag gcc cgt atc agc aat gtc tga cctggaggcc gagaccacgc cacgcacttg     868
 Glu Ala Arg Ile Ser Asn Val 
             195

 gcggcaggga cccggag                                                   885




      <210> 11
      <211> 945
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(882)

      <400> 11
 gcaggtaggt ggacggagag atagcagcga cgaggacagg ccaaacagtg acagccacgt     60

 agaggatctg gcagacaaag agacaaggtg agaaggagac tttggaagtg acccacc       117                                                                 
 atg ggg ctc agc atc ttt ttg ctc ctg tgt gtt ctt ggg ctc agc cag      165
 Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln
   1               5                  10                  15

 gca gcc aca ccg aag att ttc aat ggc act gag tgt ggg cgt aac tca      213
 Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser
              20                  25                  30

 cag ccg tgg cag gtg ggg ctg ttt gag ggc acc agc ctg cgc tgc ggg      261
 Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly
          35                  40                  45

 ggt gtc ctt att gac cac agg tgg gtc ctc aca gcg gct cac tgc agc      309
 Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser
      50                  55                  60

 ggc agc agg tac tgg gtg cgc ctg ggg gaa cac agc ctc agc cag ctc      357
 Gly Ser Arg Tyr Trp Val Arg Leu Gly Glu His Ser Leu Ser Gln Leu
  65                  70                  75                  80

 gac tgg acc gag cag atc cgg cac agc ggc ttc tct gtg acc cat ccc      405
 Asp Trp Thr Glu Gln Ile Arg His Ser Gly Phe Ser Val Thr His Pro
                  85                  90                  95

 ggc tac ctg gga gcc tcg acg agc cac gag cac gac ctc cgg ctg ctg      453
 Gly Tyr Leu Gly Ala Ser Thr Ser His Glu His Asp Leu Arg Leu Leu
             100                 105                 110

 cgg ctg cgc ctg ccc gtc cgc gta acc agc agc gtt caa ccc ctg ccc      501
 Arg Leu Arg Leu Pro Val Arg Val Thr Ser Ser Val Gln Pro Leu Pro
         115                 120                 125

 ctg ccc aat gac tgt gca acc gct ggc acc gag tgc cac gtc tca ggc      549
 Leu Pro Asn Asp Cys Ala Thr Ala Gly Thr Glu Cys His Val Ser Gly
     130                 135                 140

 tgg ggc atc acc aac cac cca cgg aac cca ttc ccg gat ctg ctc cag      597
 Trp Gly Ile Thr Asn His Pro Arg Asn Pro Phe Pro Asp Leu Leu Gln
 145                 150                 155                 160

 tgc ctc aac ctc tcc atc gtc tcc cat gcc acc tgc cat ggt gtg tat      645
 Cys Leu Asn Leu Ser Ile Val Ser His Ala Thr Cys His Gly Val Tyr
                 165                 170                 175

 ccc ggg aga atc acg agc aac atg gtg tgt gca ggc ggc gtc ccg ggg      693
 Pro Gly Arg Ile Thr Ser Asn Met Val Cys Ala Gly Gly Val Pro Gly
             180                 185                 190

 cag gat gcc tgc cag ggt gat tct ggg ggc ccc ctg gtg tgt ggg gga      741
 Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly
         195                 200                 205

 gtc ctt caa ggt ctg gtg tcc tgg ggg tct gtg ggg ccc tgt gga caa      789
 Val Leu Gln Gly Leu Val Ser Trp Gly Ser Val Gly Pro Cys Gly Gln
     210                 215                 220

 gat ggc atc cct gga gtc tac acc tat att tgc agc tcc act ctt gtt      837
 Asp Gly Ile Pro Gly Val Tyr Thr Tyr Ile Cys Ser Ser Thr Leu Val
 225                 230                 235                 240

 ggc ctg gga act tct tgg aac ttt aac tcc tgc cag ccc ttc taa gac      885
 Gly Leu Gly Thr Ser Trp Asn Phe Asn Ser Cys Gln Pro Phe 
                 245                 250

 ccacgagcgg ggtgagagaa gtgtgcaata gtctggaata aatataaatg aaggaggggc    945




      <210> 12
      <211> 2422
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (646)..(1860)

      <220>
      <221> misc_feature
      <222> (1)...(2422)
      <223> n = a,t,c or g

      <400> 12
 taggcctgat tcgcccaagt tttaatggcc tcatttagga aaagctggta cgctgcaagg     60

 accggtcccg gaattcccgg ggtcgacgat ttcgtgccac tgccgccgcc gctgccgctg    120

 ctaccgccac tagcgctgct tccactgctt ctacctcccc tcccaggacc ccgagacacc    180

 ccgggcgcga gcggcagtgc tgcttgcttg ctcctcctct cccccagccc ttcccctccg    240

 tgacctaccc actccttgca gccctcgccc gcaccttctc caacaccccg gcatccctgc    300

 accacctgct cgggcagccc cggcgggctc tgggacttgc tgtgcgcgcc gagaggaagg    360

 caagctccaa acccctgcct ggaagacggg ctgtcgcggc tgcaccacca gcaggaggag    420

 gaggagaaga aactatttcg cgatacccca ttctgcgggt gctttgccgc tgccgcttct    480

 gctgccgccg atccgagtcc gcgggttcga acaccgcagc ggtggggacg gtgggtccgg    540

 cgggcgccgg gaggaggaca ccagcggagc cctgcactct cgtgccccgc tcaccagcat    600

 ctacttgccc cctcgttcct tccccagccc tttagagaag ggacc    atg att tgg     654
                                                      Met Ile Trp
                                                        1

 aaa cgc agc gcc gtt ctc cgc ttc tac agt gtc tgc ggg ctc ctg cta      702
 Lys Arg Ser Ala Val Leu Arg Phe Tyr Ser Val Cys Gly Leu Leu Leu
       5                  10                  15

 caa gcg gct gct tca aag aat aaa gtt aaa ggc agc caa ggg cag ttt      750
 Gln Ala Ala Ala Ser Lys Asn Lys Val Lys Gly Ser Gln Gly Gln Phe
  20                  25                  30                  35

 cca cta aca cag aat gta acc gtt gtt gaa ggt gga act gca att ttg      798
 Pro Leu Thr Gln Asn Val Thr Val Val Glu Gly Gly Thr Ala Ile Leu
                  40                  45                  50

 acc tgc agg gtt gat caa aat gat aac acc tcc ctc cag tgg tca aat      846
 Thr Cys Arg Val Asp Gln Asn Asp Asn Thr Ser Leu Gln Trp Ser Asn
              55                  60                  65

 cca gct caa cag act ctg tac ttt gac gac aag aaa gct tta agg gac      894
 Pro Ala Gln Gln Thr Leu Tyr Phe Asp Asp Lys Lys Ala Leu Arg Asp
          70                  75                  80

 aat agg atc gag ctg gtt cgc gct tcc tgg cat gaa ttg agt att agt      942
 Asn Arg Ile Glu Leu Val Arg Ala Ser Trp His Glu Leu Ser Ile Ser
      85                  90                  95

 gtc agt gat gtg tct ctc tct gat gaa gga cag tac acc tgt tct tta      990
 Val Ser Asp Val Ser Leu Ser Asp Glu Gly Gln Tyr Thr Cys Ser Leu
 100                 105                 110                 115

 ttt aca atg cct gtc aaa act tcc aag gca tat ctc acc gtt ctg ggt     1038
 Phe Thr Met Pro Val Lys Thr Ser Lys Ala Tyr Leu Thr Val Leu Gly
                 120                 125                 130

 gtt cct gaa aag cct cag att agt gga ttc tca tca cca gtt atg gag     1086
 Val Pro Glu Lys Pro Gln Ile Ser Gly Phe Ser Ser Pro Val Met Glu
             135                 140                 145

 ggt gac ttg atg cag ctg act tgc aaa aca tct ggt agt aaa cct gca     1134
 Gly Asp Leu Met Gln Leu Thr Cys Lys Thr Ser Gly Ser Lys Pro Ala
         150                 155                 160

 gct gat ata aga tgg ttc aaa aat gac aaa gag att aaa gat gta aaa     1182
 Ala Asp Ile Arg Trp Phe Lys Asn Asp Lys Glu Ile Lys Asp Val Lys
     165                 170                 175

 tat tta aaa gaa gag gat gca aat cgc aag aca ttc act gtc agc agc     1230
 Tyr Leu Lys Glu Glu Asp Ala Asn Arg Lys Thr Phe Thr Val Ser Ser
 180                 185                 190                 195

 aca ctg gac ttc cga gtg gac cgg agt gat gat gga gtg gcg gtc atc     1278
 Thr Leu Asp Phe Arg Val Asp Arg Ser Asp Asp Gly Val Ala Val Ile
                 200                 205                 210

 tgc aga gta gat cac gaa tcc ctc aat gcc acc cct cag gta gcc atg     1326
 Cys Arg Val Asp His Glu Ser Leu Asn Ala Thr Pro Gln Val Ala Met
             215                 220                 225

 cag gtg cta gaa ata cac tat aca cca tca gtt aag att ata cca tcg     1374
 Gln Val Leu Glu Ile His Tyr Thr Pro Ser Val Lys Ile Ile Pro Ser
         230                 235                 240

 act cct ttt cca caa gaa gga cag cct tta att ttg act tgt gaa tcc     1422
 Thr Pro Phe Pro Gln Glu Gly Gln Pro Leu Ile Leu Thr Cys Glu Ser
     245                 250                 255

 aaa gga aaa cca ctg cca gaa cct gtt ttg tgg aca aag gat ggc gga     1470
 Lys Gly Lys Pro Leu Pro Glu Pro Val Leu Trp Thr Lys Asp Gly Gly
 260                 265                 270                 275

 gaa tta cca gat cct gac cga atg gtt gtg agt ggt agg gag cta aac     1518
 Glu Leu Pro Asp Pro Asp Arg Met Val Val Ser Gly Arg Glu Leu Asn
                 280                 285                 290

 att ctt ttc ctg aac aaa acg gat aat ggt aca tat cga tgt gaa gcc     1566
 Ile Leu Phe Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala
             295                 300                 305

 aca aac acc att ggc caa agc agt gcg gaa tat gtt ctc att gtg cat     1614
 Thr Asn Thr Ile Gly Gln Ser Ser Ala Glu Tyr Val Leu Ile Val His
         310                 315                 320

 gat cct aat gct ttg gct ggc cag aat ggc cct gac cat gct ctc ata     1662
 Asp Pro Asn Ala Leu Ala Gly Gln Asn Gly Pro Asp His Ala Leu Ile
     325                 330                 335

 gga gga ata gtg gct gta gtt gta ttt gtc acg ctg tgt tct atc ttt     1710
 Gly Gly Ile Val Ala Val Val Val Phe Val Thr Leu Cys Ser Ile Phe
 340                 345                 350                 355

 ctg ctt ggt cga tat ctg gca agg cat aaa gga acg tat tta aca aat     1758
 Leu Leu Gly Arg Tyr Leu Ala Arg His Lys Gly Thr Tyr Leu Thr Asn
                 360                 365                 370

 gaa gct aaa gga gct gaa gat gca cca gat gct gat aca gcc att atc     1806
 Glu Ala Lys Gly Ala Glu Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile
             375                 380                 385

 aat gct gaa ggc agc caa gtc aat gct gaa gag aaa aaa gag tat ttc     1854
 Asn Ala Glu Gly Ser Gln Val Asn Ala Glu Glu Lys Lys Glu Tyr Phe
         390                 395                 400

 att taa gatgcaggcc aagattctga gttttactac caggctgaat gctggagaaa      1910
 Ile 


 actggctatc atctttcaga agtcatttct accatcgtct gctaccctta ttaactccca   1970

 tactgtactg ctatcagtag ccagtgtata ccaacaatca gctgttgaaa gcatcattct   2030

 ttaattactg taccatccat aatgcaggac atttcttact gcctaaattt cacaccattg   2090

 ctcttttaac atacagtgct tgaatataca gccttaacaa tgttaatcat ctccttggat   2150

 cattatattg agtggttttt atacattaaa aaatgtatgc agagtttttt tcccccattt   2210

 tttccccttt aagtcataga ccttatcagt ttgccattgg acagctttca caagtaacag   2270

 gattagggaa ggacataatg tatttaggna taagtgaaaa aaaaaggttt acaataaaag   2330

 ttcccccntg tctgtgttca tgggcagcat attttactgg ggtgtgatgt ctcagacaac   2390

 gacagcgggc gctctgaaaa natcgccgag cg                                 2422




      <210> 13
      <211> 4857
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4803)

      <400> 13
  atg act ctg gag ggt ctg tat ttg gca agg ggc ccc ctg gcc cgg ctc      48
  Met Thr Leu Glu Gly Leu Tyr Leu Ala Arg Gly Pro Leu Ala Arg Leu
    1               5                  10                  15

 ctg ctg gcc tgg tcg gcc ctg ttg tgc atg gca ggt ggc caa ggc cgc       96
 Leu Leu Ala Trp Ser Ala Leu Leu Cys Met Ala Gly Gly Gln Gly Arg
              20                  25                  30

 tgg gac ggg gcc ttg gag gct gca ggt cct gga cgt gtg cgg agg cgg      144
 Trp Asp Gly Ala Leu Glu Ala Ala Gly Pro Gly Arg Val Arg Arg Arg
          35                  40                  45

 ggc agc cca ggc atc ttg cag ggg tgc gtg gta cct ggg atg ctg gga      192
 Gly Ser Pro Gly Ile Leu Gln Gly Cys Val Val Pro Gly Met Leu Gly
      50                  55                  60

 gac ccc ttc ggt gtg gat tgg gct gtc ctg ggg cca gcg gaa tac ccg      240
 Asp Pro Phe Gly Val Asp Trp Ala Val Leu Gly Pro Ala Glu Tyr Pro
  65                  70                  75                  80

 ggg gga tgt cca cac ggg cag ggg ctc acc aga ccc atc tcg ctg tcc      288
 Gly Gly Cys Pro His Gly Gln Gly Leu Thr Arg Pro Ile Ser Leu Ser
                  85                  90                  95

 ccg aag gcc gaa tgt gtg cgg ctc ccg gtt cca tgc cta ctg ctg tcc      336
 Pro Lys Ala Glu Cys Val Arg Leu Pro Val Pro Cys Leu Leu Leu Ser
             100                 105                 110

 agg ctg gag gac att ccc tgg cag gag cca gtg tgt cgt acg cgc gcc      384
 Arg Leu Glu Asp Ile Pro Trp Gln Glu Pro Val Cys Arg Thr Arg Ala
         115                 120                 125

 tgc ggt gaa ggc ttc tgc tcc cag ccc aac ctg tgc acc tgt gcg gat      432
 Cys Gly Glu Gly Phe Cys Ser Gln Pro Asn Leu Cys Thr Cys Ala Asp
     130                 135                 140

 ggg acg ctg gct ccc agc tgc ggg gtg agc cga ggg tca ggg tgc agt      480
 Gly Thr Leu Ala Pro Ser Cys Gly Val Ser Arg Gly Ser Gly Cys Ser
 145                 150                 155                 160

 gtg agc tgt atg aat ggg ggc acc tgc cgg ggg gcg tcc tgt ctg tgt      528
 Val Ser Cys Met Asn Gly Gly Thr Cys Arg Gly Ala Ser Cys Leu Cys
                 165                 170                 175

 cag aag ggc tac aca ggc acc gtg tgt ggg cag ccc atc tgt gac cgc      576
 Gln Lys Gly Tyr Thr Gly Thr Val Cys Gly Gln Pro Ile Cys Asp Arg
             180                 185                 190

 ggc tgc cac aat ggg ggt cgc tgc att ggg ccc aac cgc tgc gcc tgt      624
 Gly Cys His Asn Gly Gly Arg Cys Ile Gly Pro Asn Arg Cys Ala Cys
         195                 200                 205

 gtg tat ggc ttc atg gga cct caa tgt gag aga gat tac cgg acg gga      672
 Val Tyr Gly Phe Met Gly Pro Gln Cys Glu Arg Asp Tyr Arg Thr Gly
     210                 215                 220

 ccc tgc ttt ggc caa gta ggc ccc gag ggg tgc cag cat cag ctg acg      720
 Pro Cys Phe Gly Gln Val Gly Pro Glu Gly Cys Gln His Gln Leu Thr
 225                 230                 235                 240

 ggc ctc gtg tgc acc aag gca ctt tgc tgt gcc act gtg ggc cgt gcc      768
 Gly Leu Val Cys Thr Lys Ala Leu Cys Cys Ala Thr Val Gly Arg Ala
                 245                 250                 255

 tgg ggc ctt cca tgt gaa ctt tgc cct gca cag cca cac ccc tgc cgc      816
 Trp Gly Leu Pro Cys Glu Leu Cys Pro Ala Gln Pro His Pro Cys Arg
             260                 265                 270

 cgc ggc ttc atc ccc aat atc cac acg ggg gcc tgc caa gat gtg gat      864
 Arg Gly Phe Ile Pro Asn Ile His Thr Gly Ala Cys Gln Asp Val Asp
         275                 280                 285

 gag tgc cag gct gtg cca ggc ctg tgc cag gga ggc agc tgc gtc aac      912
 Glu Cys Gln Ala Val Pro Gly Leu Cys Gln Gly Gly Ser Cys Val Asn
     290                 295                 300

 atg gtg ggc tcc ttc cat tgc cgc tgt cca gtt gga cac cgg ctc agt      960
 Met Val Gly Ser Phe His Cys Arg Cys Pro Val Gly His Arg Leu Ser
 305                 310                 315                 320

 gac agc agc gcc gca tgt gaa gac tac cgg gcc ggc gcc tgc ttc tca     1008
 Asp Ser Ser Ala Ala Cys Glu Asp Tyr Arg Ala Gly Ala Cys Phe Ser
                 325                 330                 335

 gtg ctt ttc ggg ggc cgc tgt gct gga gac ctc gcc ggc cac tac act     1056
 Val Leu Phe Gly Gly Arg Cys Ala Gly Asp Leu Ala Gly His Tyr Thr
             340                 345                 350

 cgc agg cag tgc tgc tgt gac agg ggg cag gtg ctg ggc agc gtg gcc     1104
 Arg Arg Gln Cys Cys Cys Asp Arg Gly Gln Val Leu Gly Ser Val Ala
         355                 360                 365

 cgg tcc ctg agc tgt gtc ctc ctc ggg gct cca gtg aat gaa ttc cag     1152
 Arg Ser Leu Ser Cys Val Leu Leu Gly Ala Pro Val Asn Glu Phe Gln
     370                 375                 380

 caa ctg tgc gcc cag cgg ctg ccg ctg cta ccc ggc cac cct ggc ctc     1200
 Gln Leu Cys Ala Gln Arg Leu Pro Leu Leu Pro Gly His Pro Gly Leu
 385                 390                 395                 400

 ttc cct ggc ctc ctg ggc ttc gga tcc aat ggc atg ggt ccc cct ctt     1248
 Phe Pro Gly Leu Leu Gly Phe Gly Ser Asn Gly Met Gly Pro Pro Leu
                 405                 410                 415

 ggg cca gcg cga ctc aac ccc cat ggc tct gat gcg cgt ggg atc ccc     1296
 Gly Pro Ala Arg Leu Asn Pro His Gly Ser Asp Ala Arg Gly Ile Pro
             420                 425                 430

 agc ctg ggc cct ggc aac tct aat att ggc act gct acc ctg aac cag     1344
 Ser Leu Gly Pro Gly Asn Ser Asn Ile Gly Thr Ala Thr Leu Asn Gln
         435                 440                 445

 acc att gac atc tgc cga cac ttc acc aac ctg tgt ctg aat ggc cgc     1392
 Thr Ile Asp Ile Cys Arg His Phe Thr Asn Leu Cys Leu Asn Gly Arg
     450                 455                 460

 tgc ctg ccc acg cct tcc agc tac cgc tgc gag tgt aac gtg ggc tac     1440
 Cys Leu Pro Thr Pro Ser Ser Tyr Arg Cys Glu Cys Asn Val Gly Tyr
 465                 470                 475                 480

 acc cag gac gtg cgc ggc gag tgc att gat gta gac gaa tgc acc agc     1488
 Thr Gln Asp Val Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Thr Ser
                 485                 490                 495

 agc ccc tgc cac cac ggt gac tgc gtc aac atc ccc ggc acc tac cac     1536
 Ser Pro Cys His His Gly Asp Cys Val Asn Ile Pro Gly Thr Tyr His
             500                 505                 510

 tgc cgg tgc tac ccg ggc ttc cag gcc acg ccc acc agg cag gca tgc     1584
 Cys Arg Cys Tyr Pro Gly Phe Gln Ala Thr Pro Thr Arg Gln Ala Cys
         515                 520                 525

 gtg gat gtg gac gag tgc att gtc agt ggt ggc ctt tgt cac ctg ggc     1632
 Val Asp Val Asp Glu Cys Ile Val Ser Gly Gly Leu Cys His Leu Gly
     530                 535                 540

 cgc tgt gtc aac aca gag ggc agc ttc cag tgt gtc tgc aat gca ggc     1680
 Arg Cys Val Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Asn Ala Gly
 545                 550                 555                 560

 ttc gag ctc agc cct gac ggc aag aac tgt gtg gca gct gct cct gga     1728
 Phe Glu Leu Ser Pro Asp Gly Lys Asn Cys Val Ala Ala Ala Pro Gly
                 565                 570                 575

 agg cag acc cat ttg agg ctg ggg gag gcc gag ggc ttc aaa gac aat     1776
 Arg Gln Thr His Leu Arg Leu Gly Glu Ala Glu Gly Phe Lys Asp Asn
             580                 585                 590

 tcc aca gtc cag gaa ccc tat ccc cat ata aca gac cca ggt cgc ccc     1824
 Ser Thr Val Gln Glu Pro Tyr Pro His Ile Thr Asp Pro Gly Arg Pro
         595                 600                 605

 agt ggg gtc acc ctg gcc tct gcg ctc aga tgc ctg aga cct tgc ctg     1872
 Ser Gly Val Thr Leu Ala Ser Ala Leu Arg Cys Leu Arg Pro Cys Leu
     610                 615                 620

 agc tca gac tgg agt cga tgg gag cat tcc ccc atc tgg tcc cct ctt     1920
 Ser Ser Asp Trp Ser Arg Trp Glu His Ser Pro Ile Trp Ser Pro Leu
 625                 630                 635                 640

 ctg ccc gag atg ctc tgg ctc tgc tca tct gtc cac acc ccc aca ctc     1968
 Leu Pro Glu Met Leu Trp Leu Cys Ser Ser Val His Thr Pro Thr Leu
                 645                 650                 655

 ccg ggg cgc cct gag cct ctg ggg cgc gca gtt gga tgg tgc aca ggg     2016
 Pro Gly Arg Pro Glu Pro Leu Gly Arg Ala Val Gly Trp Cys Thr Gly
             660                 665                 670

 gag gcc cag att tct cca ggc ctc agc ggc cac cct ggg tac ccc gag     2064
 Glu Ala Gln Ile Ser Pro Gly Leu Ser Gly His Pro Gly Tyr Pro Glu
         675                 680                 685

 tct ggg gcc ctg ttg gag ggc cag tcc agg ggt tcg ccc gag gcg cgc     2112
 Ser Gly Ala Leu Leu Glu Gly Gln Ser Arg Gly Ser Pro Glu Ala Arg
     690                 695                 700

 gcg ggg gcc aac cga ggc gac cac aac gag tgt gcc acc agc acc atg     2160
 Ala Gly Ala Asn Arg Gly Asp His Asn Glu Cys Ala Thr Ser Thr Met
 705                 710                 715                 720

 tgc gtc aac ggc gtg tgt ctc aac gag gat tgg cag ctt ctc ctg cct     2208
 Cys Val Asn Gly Val Cys Leu Asn Glu Asp Trp Gln Leu Leu Leu Pro
                 725                 730                 735

 ctg caa acc cgg gct tcc tgc tgg cgc ctg gcg gcc att act gca ctg     2256
 Leu Gln Thr Arg Ala Ser Cys Trp Arg Leu Ala Ala Ile Thr Ala Leu
             740                 745                 750

 gac gcc cgg cat ctg cgt gaa cgg cac tgt acc aac acc gag ggc tcc     2304
 Asp Ala Arg His Leu Arg Glu Arg His Cys Thr Asn Thr Glu Gly Ser
         755                 760                 765

 ttc cgc tgc cag tgc ctg ggg ggg ctg gcg gta ggc acg gat ggc cgc     2352
 Phe Arg Cys Gln Cys Leu Gly Gly Leu Ala Val Gly Thr Asp Gly Arg
     770                 775                 780

 gtg tgc gtg gac acc cac gtg cgc agc acc tgc tat ggg gcc atc gag     2400
 Val Cys Val Asp Thr His Val Arg Ser Thr Cys Tyr Gly Ala Ile Glu
 785                 790                 795                 800

 aag ggc tcc tgt gcc cgc ccc ttc cct ggc act gtc acc aag tcc gag     2448
 Lys Gly Ser Cys Ala Arg Pro Phe Pro Gly Thr Val Thr Lys Ser Glu
                 805                 810                 815

 tgc tgc tgt gcc aat ccg gac cac ggt ttt ggg gag ccc tgc cag ctt     2496
 Cys Cys Cys Ala Asn Pro Asp His Gly Phe Gly Glu Pro Cys Gln Leu
             820                 825                 830

 tgt cct gcc aaa gac tcc gct gag ttc cag gca ctg tgc agc agt ggg     2544
 Cys Pro Ala Lys Asp Ser Ala Glu Phe Gln Ala Leu Cys Ser Ser Gly
         835                 840                 845

 ctt ggc att acc acg gat ggt cga gac atc aac gag tgt gct ctg gat     2592
 Leu Gly Ile Thr Thr Asp Gly Arg Asp Ile Asn Glu Cys Ala Leu Asp
     850                 855                 860

 cct gag gtt tgt gcc aat ggc gtg tgc gag aac ctt cgg ggc agc tac     2640
 Pro Glu Val Cys Ala Asn Gly Val Cys Glu Asn Leu Arg Gly Ser Tyr
 865                 870                 875                 880

 cgc tgt gtc tgc aac ctg ggt tat gag gca ggt gcc tca ggc aag gac     2688
 Arg Cys Val Cys Asn Leu Gly Tyr Glu Ala Gly Ala Ser Gly Lys Asp
                 885                 890                 895

 tgc aca gac gtg gat gag tgt gcc ctc aac agc ctc ctg tgt gac aac     2736
 Cys Thr Asp Val Asp Glu Cys Ala Leu Asn Ser Leu Leu Cys Asp Asn
             900                 905                 910

 ggg tgg tgc cag aat agc cct ggc agc tac agc tgc tcc tgc ccc ccc     2784
 Gly Trp Cys Gln Asn Ser Pro Gly Ser Tyr Ser Cys Ser Cys Pro Pro
         915                 920                 925

 ggc ttc cac ttc tgg cag gac acg gag atc tgc aaa gat gtc gac gaa     2832
 Gly Phe His Phe Trp Gln Asp Thr Glu Ile Cys Lys Asp Val Asp Glu
     930                 935                 940

 tgc ctg tcc agc ccg tgt gtg agt ggc gtc tgt cgg aac ctg gcc ggc     2880
 Cys Leu Ser Ser Pro Cys Val Ser Gly Val Cys Arg Asn Leu Ala Gly
 945                 950                 955                 960

 tcc tac acc tgc aaa tgt ggc cct ggc agc cgg ctg gac ccc tct ggt     2928
 Ser Tyr Thr Cys Lys Cys Gly Pro Gly Ser Arg Leu Asp Pro Ser Gly
                 965                 970                 975

 acc ttc tgt cta gac agc acc aag ggc acc tgc tgg ctg aag atc cag     2976
 Thr Phe Cys Leu Asp Ser Thr Lys Gly Thr Cys Trp Leu Lys Ile Gln
             980                 985                 990

 gag agc cgc tgt gag gtg aac ctt cag gga gcc agc ctg cgg tct gag     3024
 Glu Ser Arg Cys Glu Val Asn Leu Gln Gly Ala Ser Leu Arg Ser Glu
         995                1000                1005

 tgc tgc gcc acc ctc ggg gca gcc tgg ggg agc ccc tgc gaa cgc tgc     3072
 Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser Pro Cys Glu Arg Cys
    1010                1015                1020

 gag atc ggt agt atc ctc ctt gag gcc tcc cag gca ccc atg gga aaa     3120
 Glu Ile Gly Ser Ile Leu Leu Glu Ala Ser Gln Ala Pro Met Gly Lys
1025                1030                1035                1040

 gcc ctc cat ggg gcg ggt ccc ccc ttg ggc tgg cat gag aaa atg act     3168
 Ala Leu His Gly Ala Gly Pro Pro Leu Gly Trp His Glu Lys Met Thr
                1045                1050                1055

 cct ctc ttc act ctt gtt ctc cca gtt gca gat agt acg cct gag gta     3216
 Pro Leu Phe Thr Leu Val Leu Pro Val Ala Asp Ser Thr Pro Glu Val
            1060                1065                1070

 acg gtc cgg aat tcc cgg gtc gac gaa tgc ctg tcc agc ccg tgt gtg     3264
 Thr Val Arg Asn Ser Arg Val Asp Glu Cys Leu Ser Ser Pro Cys Val
        1075                1080                1085

 agt ggc gtc tgt cgg aac ctg gcc ggc tcc tac acc tgc aaa tgt ggc     3312
 Ser Gly Val Cys Arg Asn Leu Ala Gly Ser Tyr Thr Cys Lys Cys Gly
    1090                1095                1100

 cct ggc agc cgg ctg gac ccc tct ggt acc ttc tgt cta gac agc acc     3360
 Pro Gly Ser Arg Leu Asp Pro Ser Gly Thr Phe Cys Leu Asp Ser Thr
1105                1110                1115                1120

 aag ggc acc tgc tgg ctg aag atc cag gag agc cgc tgt gag gtg aac     3408
 Lys Gly Thr Cys Trp Leu Lys Ile Gln Glu Ser Arg Cys Glu Val Asn
                1125                1130                1135

 ctt cag gga gcc agc ctg cgg tct gag tgc tgc gcc acc ctc ggg gca     3456
 Leu Gln Gly Ala Ser Leu Arg Ser Glu Cys Cys Ala Thr Leu Gly Ala
            1140                1145                1150

 gcc tgg ggg agc ccc tgc gaa cgc tgc gag atc gac cct gcc tgt gcc     3504
 Ala Trp Gly Ser Pro Cys Glu Arg Cys Glu Ile Asp Pro Ala Cys Ala
        1155                1160                1165

 cgg ggc ttt gcc cgg atg acg ggt gtc acc tgc aat gat gtg aac gag     3552
 Arg Gly Phe Ala Arg Met Thr Gly Val Thr Cys Asn Asp Val Asn Glu
    1170                1175                1180

 tgt gag tcc ttc ccg gga gtc tgt ccc aac ggg cgt tgc gtc aac act     3600
 Cys Glu Ser Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Thr
1185                1190                1195                1200

 gct ggg tct ttc cgc tgt gag tgt cca gag ggc ctg atg ctg gac gcc     3648
 Ala Gly Ser Phe Arg Cys Glu Cys Pro Glu Gly Leu Met Leu Asp Ala
                1205                1210                1215

 tca ggc cgg ctg tgc gtg gat gtg aga ttg gaa cca tgt ttc ctg cga     3696
 Ser Gly Arg Leu Cys Val Asp Val Arg Leu Glu Pro Cys Phe Leu Arg
            1220                1225                1230

 tgg gat gag gat gag tgt ggg gtc acc ctg cct ggc aag tac cgg atg     3744
 Trp Asp Glu Asp Glu Cys Gly Val Thr Leu Pro Gly Lys Tyr Arg Met
        1235                1240                1245

 gac gtc tgc tgc tgc tcc atc ggg gcc gtg tgg gga gtc gag tgc gag     3792
 Asp Val Cys Cys Cys Ser Ile Gly Ala Val Trp Gly Val Glu Cys Glu
    1250                1255                1260

 gcc tgc ccg gat ccc gag tct ctg gag ttc gcc agc ctg tgc ccg cgg     3840
 Ala Cys Pro Asp Pro Glu Ser Leu Glu Phe Ala Ser Leu Cys Pro Arg
1265                1270                1275                1280

 ggg ctg ggc ttc gcc agc cgg gac ttc ctg tct ggc cga cca ttc tat     3888
 Gly Leu Gly Phe Ala Ser Arg Asp Phe Leu Ser Gly Arg Pro Phe Tyr
                1285                1290                1295

 aaa gat gtg aat gaa tgc aag gtg ttc cct ggc ctc tgc acg cac ggt     3936
 Lys Asp Val Asn Glu Cys Lys Val Phe Pro Gly Leu Cys Thr His Gly
            1300                1305                1310

 acc tgc aga aac acg gtg ggc agc ttc cac tgc gcc tgt gcg ggg ggc     3984
 Thr Cys Arg Asn Thr Val Gly Ser Phe His Cys Ala Cys Ala Gly Gly
        1315                1320                1325

 ttc gcc ctg gat gcc cag gaa cgg aac tgc aca gat atc gac gag tgt     4032
 Phe Ala Leu Asp Ala Gln Glu Arg Asn Cys Thr Asp Ile Asp Glu Cys
    1330                1335                1340

 cgc atc tct cct gac ctc tgc ggc cag ggc acc tgt gtc aac acg ccg     4080
 Arg Ile Ser Pro Asp Leu Cys Gly Gln Gly Thr Cys Val Asn Thr Pro
1345                1350                1355                1360

 ggc agc ttt gag tgc gag tgt ttt ccc ggc tac gag agt ggc ttc atg     4128
 Gly Ser Phe Glu Cys Glu Cys Phe Pro Gly Tyr Glu Ser Gly Phe Met
                1365                1370                1375

 ctg atg aag aac tgc atg gac gtg gac gag tgt gca agg gac ccg ctg     4176
 Leu Met Lys Asn Cys Met Asp Val Asp Glu Cys Ala Arg Asp Pro Leu
            1380                1385                1390

 ctc tgc cgg gga ggc act tgc acc aac acg gat ggg agc tac aag tgc     4224
 Leu Cys Arg Gly Gly Thr Cys Thr Asn Thr Asp Gly Ser Tyr Lys Cys
        1395                1400                1405

 cag tgt ccc cct ggg cat gag ctg acg gcc aag ggc act gcc tgt gag     4272
 Gln Cys Pro Pro Gly His Glu Leu Thr Ala Lys Gly Thr Ala Cys Glu
    1410                1415                1420

 gac atc gat gag tgc tcc ctg agt gat ggc ctg tgt ccc cat ggc cag     4320
 Asp Ile Asp Glu Cys Ser Leu Ser Asp Gly Leu Cys Pro His Gly Gln
1425                1430                1435                1440

 tgt gtc aat gtc atc ggt gcc ttc cag tgc tcc tgc cat gcc ggc ttc     4368
 Cys Val Asn Val Ile Gly Ala Phe Gln Cys Ser Cys His Ala Gly Phe
                1445                1450                1455

 cag agc aca cct gac cgc cag ggc tgc gtg gac atc aac gaa tgc cgg     4416
 Gln Ser Thr Pro Asp Arg Gln Gly Cys Val Asp Ile Asn Glu Cys Arg
            1460                1465                1470

 gtc cag aat ggt ggg tgt gac gtg cac tgt att aac act gag ggc agc     4464
 Val Gln Asn Gly Gly Cys Asp Val His Cys Ile Asn Thr Glu Gly Ser
        1475                1480                1485

 tac cgg tgc agc tgt ggg cag ggc tac tcg ctg atg ccc gac gga agg     4512
 Tyr Arg Cys Ser Cys Gly Gln Gly Tyr Ser Leu Met Pro Asp Gly Arg
    1490                1495                1500

 gca tgt gca gac gtg gac gag tgt gaa gag aac ccc cgc gtt tgt gac     4560
 Ala Cys Ala Asp Val Asp Glu Cys Glu Glu Asn Pro Arg Val Cys Asp
1505                1510                1515                1520

 caa ggc cac tgc acc aac atg cca ggg ggt cac cgc tgc ctg tgc tat     4608
 Gln Gly His Cys Thr Asn Met Pro Gly Gly His Arg Cys Leu Cys Tyr
                1525                1530                1535

 gat ggc ttc atg gcc acg cca gac atg agg aca tgt gtt gat gtg gct     4656
 Asp Gly Phe Met Ala Thr Pro Asp Met Arg Thr Cys Val Asp Val Ala
            1540                1545                1550

 ctc cta cct cct gct ctt tat cct gga cct ggt cat ctg cct cat tgc     4704
 Leu Leu Pro Pro Ala Leu Tyr Pro Gly Pro Gly His Leu Pro His Cys
        1555                1560                1565

 ctg cct ggg act ggc caa gcg ctc caa gtg tct cct ggc ctc gat gct     4752
 Leu Pro Gly Thr Gly Gln Ala Leu Gln Val Ser Pro Gly Leu Asp Ala
    1570                1575                1580

 gtg ctg tgg ggc act gag cct gct cct cag ttg ggc atc cct ggc cgc     4800
 Val Leu Trp Gly Thr Glu Pro Ala Pro Gln Leu Gly Ile Pro Gly Arg
1585                1590                1595                1600

 tga tggc tctgcggcag tggccaccag tgacttctgt gtggctcctg acaccttcat     4857
 






      <210> 14
      <211> 1173
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (43)..(585)

      <220>
      <221> misc_feature
      <222> (1)...(1173)
      <223> n = a,t,c or g

      <400> 14
 ggttttcctc ttctgatctg catcatttca ctgtcatttg cc   atg gac agt tac      54
                                                  Met Asp Ser Tyr
                                                    1

 gga aca agc aac aat tgc tgg ctg tcg ttg gcg agt ggc gcc atc tgg      102
 Gly Thr Ser Asn Asn Cys Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp
   5                  10                  15                  20

 gcc ttt gta gcc cct gcc ctg ttt gtc atc gtg gtc aac att ggc atc      150
 Ala Phe Val Ala Pro Ala Leu Phe Val Ile Val Val Asn Ile Gly Ile
                  25                  30                  35

 ctc atc gct gtg acc aga gtc atc tca cag atc agc gcc gac aac tac      198
 Leu Ile Ala Val Thr Arg Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr
              40                  45                  50

 aag atc cat gga gac ccc agt gcc ttc aag ttg acg gcc aag gca gtg      246
 Lys Ile His Gly Asp Pro Ser Ala Phe Lys Leu Thr Ala Lys Ala Val
          55                  60                  65

 gcc gtg ctg ctg ccc atc ctg ggt acc tcg tgg gtc ttt ggc gtg ctt      294
 Ala Val Leu Leu Pro Ile Leu Gly Thr Ser Trp Val Phe Gly Val Leu
      70                  75                  80

 gct gtc aac ggt tgt gct gtg gtt ttc cag tac atg ttt gcc acg ctc      342
 Ala Val Asn Gly Cys Ala Val Val Phe Gln Tyr Met Phe Ala Thr Leu
  85                  90                  95                 100

 aac tcc ctg cag gga ctg ttc ata ttc ctc ttt cat tgt ctc ctg aat      390
 Asn Ser Leu Gln Gly Leu Phe Ile Phe Leu Phe His Cys Leu Leu Asn
                 105                 110                 115

 tca gag gtg aga gcc gcc ttc aag cac aaa acc aag gtc tgg tcg ctc      438
 Ser Glu Val Arg Ala Ala Phe Lys His Lys Thr Lys Val Trp Ser Leu
             120                 125                 130

 acg agc agc tcc gcc cgc acc tcc aac gcg aag ccc ttc cac tcg gac      486
 Thr Ser Ser Ser Ala Arg Thr Ser Asn Ala Lys Pro Phe His Ser Asp
         135                 140                 145

 ctc atg aat ggg acc cgg cca ggc atg gcc tcc acc aag ctc agc cct      534
 Leu Met Asn Gly Thr Arg Pro Gly Met Ala Ser Thr Lys Leu Ser Pro
     150                 155                 160

 tgg gac aag agc agc cac tct gcc cac cgt gtc gac ctg tca gcc gtg      582
 Trp Asp Lys Ser Ser His Ser Ala His Arg Val Asp Leu Ser Ala Val
 165                 170                 175                 180

 tga gccg ggaggctgcc aaccaggcca ggctgcgctc agaacacacc cccccaaaca      639
 


 gaatgaaatg ccccaccttt gcccatggac cctctccttg ctgcttgaga gatttgggnn    699

 nnnnnnnnnn anacannngn nctnnnctgn ngactctgct gtcggagcac actgctcatc    759

 ccagcaacct gatgcccagg ccagcgtggg ccctcctgcc ttgcatacac ccgtgggctg    819

 agtgacttcc tcgggggatt cccaggacac agtggcctga ctgtgatggt gcccttgagc    879

 ctcccttcat cactcaacat cagacccacc gagggcagga cactctgtgc ccgtcctaca    939

 gaaccaggaa gggaagttca gcctctgtgc cttgtggggc ttgggggact cagggccaaa    999

 aaggtgggtt taggtcctca tccaccctcc atactgcgcc cgccaactgg gaggttgtga   1059

 ggtaaaacta tcggagaccc cactgtttga atccatcgat gtggaaagtt cccccaagcc   1119

 tgcgcttgtt ccgtgtggtt ttcttaatgg gtggcccccg gtgcctccac ctcc         1173




      <210> 15
      <211> 1672
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(1165)

      <400> 15
 cgtagcgccc gagtgtcggg gggctttccc ttttcggtcc  atg atg ccg gga acc      55
                                              Met Met Pro Gly Thr
                                                1               5

 gcg ctg gag ggc gtg ctg ctg gcc gtg ctg ctg gtg ggg ctg cag acc      103
 Ala Leu Glu Gly Val Leu Leu Ala Val Leu Leu Val Gly Leu Gln Thr
                  10                  15                  20

 gcg acg ggt cgc ctg ctg agt ggg cag cca gtc tgc cgg gga ggg aca      151
 Ala Thr Gly Arg Leu Leu Ser Gly Gln Pro Val Cys Arg Gly Gly Thr
              25                  30                  35

 cag agg cct tgt tat aaa gtc att tac ttc cat gat act tct cga aga      199
 Gln Arg Pro Cys Tyr Lys Val Ile Tyr Phe His Asp Thr Ser Arg Arg
          40                  45                  50

 ctg aac ttt gag gaa gcc aaa gaa gcc tgc agg agg gat gga ggc cag      247
 Leu Asn Phe Glu Glu Ala Lys Glu Ala Cys Arg Arg Asp Gly Gly Gln
      55                  60                  65

 cta gtc agc atc gag tct gaa gat gaa cag aaa ctg ata gaa aag ttc      295
 Leu Val Ser Ile Glu Ser Glu Asp Glu Gln Lys Leu Ile Glu Lys Phe
  70                  75                  80                  85

 att gaa aac ctc ttg cca tct gat ggt gac ttc tgg att ggg ctc agg      343
 Ile Glu Asn Leu Leu Pro Ser Asp Gly Asp Phe Trp Ile Gly Leu Arg
                  90                  95                 100

 agg cgt gag gag aaa caa agc aat agc aca gcc tgc cag gac ctt tat      391
 Arg Arg Glu Glu Lys Gln Ser Asn Ser Thr Ala Cys Gln Asp Leu Tyr
             105                 110                 115

 gct tgg act gat ggc agc ata tca caa ttt agg aac tgg tat gtg gat      439
 Ala Trp Thr Asp Gly Ser Ile Ser Gln Phe Arg Asn Trp Tyr Val Asp
         120                 125                 130

 gag ccg tcc tgc ggc agc gag gtc tgc gtg gtc atg tac cat cag cca      487
 Glu Pro Ser Cys Gly Ser Glu Val Cys Val Val Met Tyr His Gln Pro
     135                 140                 145

 tcg gca ccc gct ggc atc gga ggc ccc tac atg ttc cag tgg aat gat      535
 Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met Phe Gln Trp Asn Asp
 150                 155                 160                 165

 gac cgg tgc aac atg aag aac aat ttc att tgc aaa tat tct gat gag      583
 Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys Lys Tyr Ser Asp Glu
                 170                 175                 180

 aaa cca gca gtt cct tct aga gaa gct gaa ggt gag gaa aca gag ctg      631
 Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly Glu Glu Thr Glu Leu
             185                 190                 195

 aca aca cct gta ctt cca gaa gaa aca cag gaa gaa gat gcc aaa aaa      679
 Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu Glu Asp Ala Lys Lys
         200                 205                 210

 aca ttt aaa gaa agt aga gaa gct gcc ttg aat ctg gcc tac atc cta      727
 Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn Leu Ala Tyr Ile Leu
     215                 220                 225

 atc ccc agc att ccc ctt ctc ctc ctc ctt gtg gtc acc aca gtt gta      775
 Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val Val Thr Thr Val Val
 230                 235                 240                 245

 tgt tgg gtt tgg atc tgt aga aaa aga aaa cgg gag cag cca gac cct      823
 Cys Trp Val Trp Ile Cys Arg Lys Arg Lys Arg Glu Gln Pro Asp Pro
                 250                 255                 260

 agc aca aag aag caa cac acc atc tgg ccc tct cct cac cag gga aac      871
 Ser Thr Lys Lys Gln His Thr Ile Trp Pro Ser Pro His Gln Gly Asn
             265                 270                 275

 agc ccg gac cta gag gtc tac aat gtc ata aga aaa caa agc gaa gct      919
 Ser Pro Asp Leu Glu Val Tyr Asn Val Ile Arg Lys Gln Ser Glu Ala
         280                 285                 290

 gac tta gct gag acc cgg cca gac ctg aag aat att tca ttc cga gtg      967
 Asp Leu Ala Glu Thr Arg Pro Asp Leu Lys Asn Ile Ser Phe Arg Val
     295                 300                 305

 tgt tcg gga gaa gcc act ccc gat gac atg tct tgt gac tat gac aac     1015
 Cys Ser Gly Glu Ala Thr Pro Asp Asp Met Ser Cys Asp Tyr Asp Asn
 310                 315                 320                 325

 atg gct gtg aac cca tca gaa agt ggg ttt gtg act ctg gtg agc gtg     1063
 Met Ala Val Asn Pro Ser Glu Ser Gly Phe Val Thr Leu Val Ser Val
                 330                 335                 340

 gag agt gga ttt gtg acc aat gac att tat gag ttc tcc cca gac caa     1111
 Glu Ser Gly Phe Val Thr Asn Asp Ile Tyr Glu Phe Ser Pro Asp Gln
             345                 350                 355

 atg ggg agg agt aag gag tct gga tgg gtg gaa aat gaa ata tat ggt     1159
 Met Gly Arg Ser Lys Glu Ser Gly Trp Val Glu Asn Glu Ile Tyr Gly
         360                 365                 370

 tat tag gacatataaa aaactgaaac tgacaacaat ggaaaagaaa tgataagcaa      1215
 Tyr 


 aatcctctta ttttctataa ggaaaataca cagaaggtct atgaacaagc ttagatcagg   1275

 tcctgtggat gagcatgtgg tccccacgac ctcctgttgg acccccacgt tttggctgta   1335

 tcctttatcc cagccagtca tccagctcga ccttatgaga aggtaccttg cccaggtctg   1395

 gcacatagta gagtctcaat aaatgtcact tggttggttg tatctaactt ttaagggaca   1455

 gagctttacc tggcagtgat aaagatgggc tgtggagctt ggaaaaccac ctctgttttc   1515

 cttgctctat acagcagcac atattatcat acagacagaa aatccagaat cttttcaaag   1575

 cccacatatg gtagcacagg ctggcctgtg catcggcaat tctcatatct gtttttttca   1635

 aagaataaaa tcaaataaag agcaaaaaaa aaaaaaa                            1672




      <210> 16
      <211> 1635
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1512)

      <400> 16
  atg tac ttg gtg gcg ggg gac agg ggg ttg gcc ggc tgc ggg cac ctc      48
  Met Tyr Leu Val Ala Gly Asp Arg Gly Leu Ala Gly Cys Gly His Leu
    1               5                  10                  15

 ctg gtc tcg ctg ctg ggg ctg ctg ctg ctg ctg gcg cgc tcc ggc acc       96
 Leu Val Ser Leu Leu Gly Leu Leu Leu Leu Leu Ala Arg Ser Gly Thr
              20                  25                  30

 cgg gcg ctg gtc tgc ctg ccc tgt gac gag tcc aag tgc gag gag ccc      144
 Arg Ala Leu Val Cys Leu Pro Cys Asp Glu Ser Lys Cys Glu Glu Pro
          35                  40                  45

 agg aac tgc ccg ggg agc atc gtg cag ggc gtc tgc ggc tgc tgc tac      192
 Arg Asn Cys Pro Gly Ser Ile Val Gln Gly Val Cys Gly Cys Cys Tyr
      50                  55                  60

 acg tgc gcc agc cag agg aac gag agc tgc ggc ggc acc ttc ggg att      240
 Thr Cys Ala Ser Gln Arg Asn Glu Ser Cys Gly Gly Thr Phe Gly Ile
  65                  70                  75                  80

 tac gga acc tgc gac cgg ggg ctg cgt tgt gtc atc cgc ccc ccg ctc      288
 Tyr Gly Thr Cys Asp Arg Gly Leu Arg Cys Val Ile Arg Pro Pro Leu
                  85                  90                  95

 aat ggc gac tcc ctc acc gag tac gaa gcg ggc gtt tgc gaa gat gag      336
 Asn Gly Asp Ser Leu Thr Glu Tyr Glu Ala Gly Val Cys Glu Asp Glu
             100                 105                 110

 aac tgg act gat gac caa ctg ctt ggt ttt aaa cca tgc aat gaa aac      384
 Asn Trp Thr Asp Asp Gln Leu Leu Gly Phe Lys Pro Cys Asn Glu Asn
         115                 120                 125

 ctt att gct ggc tgc aat ata atc aat ggg aaa tgt gaa tgt aac acc      432
 Leu Ile Ala Gly Cys Asn Ile Ile Asn Gly Lys Cys Glu Cys Asn Thr
     130                 135                 140

 att cga acc tgc agc aat ccc ttt gag ttt cca agt cag gat atg tgc      480
 Ile Arg Thr Cys Ser Asn Pro Phe Glu Phe Pro Ser Gln Asp Met Cys
 145                 150                 155                 160

 ctt tca gct tta aag aga att gaa gaa gag aag cca gat tgc tcc aag      528
 Leu Ser Ala Leu Lys Arg Ile Glu Glu Glu Lys Pro Asp Cys Ser Lys
                 165                 170                 175

 gcc cgc tgt gaa gtc cag ttc tct cca cgt tgt cct gaa gat tct gtt      576
 Ala Arg Cys Glu Val Gln Phe Ser Pro Arg Cys Pro Glu Asp Ser Val
             180                 185                 190

 ctg atc gag ggt tat gct cct cct ggg gag tgc tgt ccc tta ccc agc      624
 Leu Ile Glu Gly Tyr Ala Pro Pro Gly Glu Cys Cys Pro Leu Pro Ser
         195                 200                 205

 cgc tgc gtg tgc aac ccc gca ggc tgt ctg cgc aaa gtc tgc cag ccg      672
 Arg Cys Val Cys Asn Pro Ala Gly Cys Leu Arg Lys Val Cys Gln Pro
     210                 215                 220

 gga aac ctg aac ata cta gtg tca aaa gcc tca ggg aag ccg gga gag      720
 Gly Asn Leu Asn Ile Leu Val Ser Lys Ala Ser Gly Lys Pro Gly Glu
 225                 230                 235                 240

 tgc tgt gac ctc tat gag tgc aaa cca gtt ttc ggc gtg gac tgc agg      768
 Cys Cys Asp Leu Tyr Glu Cys Lys Pro Val Phe Gly Val Asp Cys Arg
                 245                 250                 255

 act gtg gaa tgc cct cct gtt cag cag acc gcc cgg tgt ccc ccg gac      816
 Thr Val Glu Cys Pro Pro Val Gln Gln Thr Ala Arg Cys Pro Pro Asp
             260                 265                 270

 agc tat gaa act caa gtc aga cta act gca gat ggt tgc tgt cct ttg      864
 Ser Tyr Glu Thr Gln Val Arg Leu Thr Ala Asp Gly Cys Cys Pro Leu
         275                 280                 285

 cca cca aga tgc gag tgt ctc tct ggc tta tgt ggt ttc ccc gtg tgt      912
 Pro Pro Arg Cys Glu Cys Leu Ser Gly Leu Cys Gly Phe Pro Val Cys
     290                 295                 300

 gag gtg gga tcc act ccc cgc ata gtc tct cgt ggc gat ggg aca cct      960
 Glu Val Gly Ser Thr Pro Arg Ile Val Ser Arg Gly Asp Gly Thr Pro
 305                 310                 315                 320

 gga aag tgc tgt gat gtc ttt gaa tgt gtt aat gat aca aag cca gcc     1008
 Gly Lys Cys Cys Asp Val Phe Glu Cys Val Asn Asp Thr Lys Pro Ala
                 325                 330                 335

 tgc gta ttt aac aat gtg gaa tat tat gat gga gac atg ttt cga atg     1056
 Cys Val Phe Asn Asn Val Glu Tyr Tyr Asp Gly Asp Met Phe Arg Met
             340                 345                 350

 gac aac tgt cgg ttc tgt cga tgc caa ggg ggc gtt gcc atc tgc ttc     1104
 Asp Asn Cys Arg Phe Cys Arg Cys Gln Gly Gly Val Ala Ile Cys Phe
         355                 360                 365

 act gcc cag tgt ggt gag ata aac tgc gag agg tac tac gtg ccc gaa     1152
 Thr Ala Gln Cys Gly Glu Ile Asn Cys Glu Arg Tyr Tyr Val Pro Glu
     370                 375                 380

 gga gag tgc tgc cca gtg tgt gaa gat cca gtg tat cct ttt aat aat     1200
 Gly Glu Cys Cys Pro Val Cys Glu Asp Pro Val Tyr Pro Phe Asn Asn
 385                 390                 395                 400

 ccc gct ggc tgc tat gcc aat ggc ctg atc ctt gcc cac gga gac cgg     1248
 Pro Ala Gly Cys Tyr Ala Asn Gly Leu Ile Leu Ala His Gly Asp Arg
                 405                 410                 415

 tgg cgg gaa gac gac tgc aca ttc tgc cag tgc gtc aac ggt gaa cgc     1296
 Trp Arg Glu Asp Asp Cys Thr Phe Cys Gln Cys Val Asn Gly Glu Arg
             420                 425                 430

 cac tgc gtt gcg acc gtc tgc gga cag acc tgc aca aac cct gtg aaa     1344
 His Cys Val Ala Thr Val Cys Gly Gln Thr Cys Thr Asn Pro Val Lys
         435                 440                 445

 gtg cct ggg gag tgt tgc cct gtg tgc gaa gaa cca acc atc atc aca     1392
 Val Pro Gly Glu Cys Cys Pro Val Cys Glu Glu Pro Thr Ile Ile Thr
     450                 455                 460

 gtt gat cca cct gca tgt ggg gag tta tca aac tgc act ctg aca ggg     1440
 Val Asp Pro Pro Ala Cys Gly Glu Leu Ser Asn Cys Thr Leu Thr Gly
 465                 470                 475                 480

 aag gac tgc att aat ggt ttc aaa cgc gat cac aat ggt tgt cgg acc     1488
 Lys Asp Cys Ile Asn Gly Phe Lys Arg Asp His Asn Gly Cys Arg Thr
                 485                 490                 495

 tgt cag tgc ata aac agt gag tag acagaagact gtatgttttt tctgaggcct    1542
 Cys Gln Cys Ile Asn Ser Glu 
             500

 aatatgatat tgtcaaagca tattatgtaa ttgaatatct ttttcacttc tgttcagaca   1602

 ttcccttgac aacctgaaaa aaaggggaaa aaa                                1635




      <210> 17
      <211> 710
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(492)

      <400> 17
 cggacgcgtg gggcagaagg tgcaagccag agctcaggca gaacttccag tattgcatct     60

 gggatctgca tttgccactg gttgcagatc aggcggacga ggagccggga aggcagagcc    120
                                                                 
 atg tgg ctg ccc cct gct ctg ctc ctt ctc agc ctc tca ggc tgt ttc      168
 Met Trp Leu Pro Pro Ala Leu Leu Leu Leu Ser Leu Ser Gly Cys Phe
   1               5                  10                  15

 tcc atc caa ggc cca gag tct gtg aga gcc cca gag cag ggg tcc ctg      216
 Ser Ile Gln Gly Pro Glu Ser Val Arg Ala Pro Glu Gln Gly Ser Leu
              20                  25                  30

 acg gtt caa tgc cac tat aag caa gga tgg gag acc tac att aag tgg      264
 Thr Val Gln Cys His Tyr Lys Gln Gly Trp Glu Thr Tyr Ile Lys Trp
          35                  40                  45

 tgg tgc cga ggg gtg cgc tgg gat aca tgc aag atc ctc att gaa acc      312
 Trp Cys Arg Gly Val Arg Trp Asp Thr Cys Lys Ile Leu Ile Glu Thr
      50                  55                  60

 aga ggg tcg gag caa gga gag aag agt gac cgt gtg tcc atc aag gac      360
 Arg Gly Ser Glu Gln Gly Glu Lys Ser Asp Arg Val Ser Ile Lys Asp
  65                  70                  75                  80

 aat cag aaa gac cgc acg ttc act gtg acc atg gag ggg ctc agg cga      408
 Asn Gln Lys Asp Arg Thr Phe Thr Val Thr Met Glu Gly Leu Arg Arg
                  85                  90                  95

 gat gac gca gat gtt tac tgg tgt ggg att gaa aga aga gga cct gac      456
 Asp Asp Ala Asp Val Tyr Trp Cys Gly Ile Glu Arg Arg Gly Pro Asp
             100                 105                 110

 ctt ggg act caa gtg aaa gtg att gtt gac cca tag ggag cggcttcctc      506
 Leu Gly Thr Gln Val Lys Val Ile Val Asp Pro 
         115                 120

 aacagcaagc tcacctacca acagcaatat ggcagtgttg atcggctccc acaagaggaa    566

 ccactacatg ctcctggtat ttgtgaaggt gcccatcttg ctcatcttgg tcactgccat    626

 cctctggttg aaggggtctc agagggtccc tgaggagcca ggggaacagc ctatctacat    686

 gaacttctcc gaacctctga ctaa                                           710




      <210> 18
      <211> 688
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(470)

      <400> 18
 cggaattccc gggtcgacga tttcgtggga ttttgttttc caggctgttt ctccatccaa     60

 ggcccagagt ccgtgagagc cccagagcag gggttcgtgc cggtgca  atg agc tgt     116
                                                      Met Ser Cys
                                                        1

 atc ttg gga ttc tgt ttt cca ggc tgt ttc tcc atc caa ggc cca gag      164
 Ile Leu Gly Phe Cys Phe Pro Gly Cys Phe Ser Ile Gln Gly Pro Glu
       5                  10                  15

 tct gtg aga gcc cca gag cag ggg tcc ctg acg gtt caa tgc cac tat      212
 Ser Val Arg Ala Pro Glu Gln Gly Ser Leu Thr Val Gln Cys His Tyr
  20                  25                  30                  35

 aag caa gga tgg gag acc tac att aag tgg tgg tgc cga ggg gtg cgc      260
 Lys Gln Gly Trp Glu Thr Tyr Ile Lys Trp Trp Cys Arg Gly Val Arg
                  40                  45                  50

 tgg gat aca tgc aag atc ctc att gaa acc aga ggg tcg gag caa gga      308
 Trp Asp Thr Cys Lys Ile Leu Ile Glu Thr Arg Gly Ser Glu Gln Gly
              55                  60                  65

 gag aag agt gac cgt gtg tcc atc aag gac aat cag aaa gac cgc acg      356
 Glu Lys Ser Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asp Arg Thr
          70                  75                  80

 ttc act gtg acc atg gag ggg ctc agg cga gat gac gca gat gtt tac      404
 Phe Thr Val Thr Met Glu Gly Leu Arg Arg Asp Asp Ala Asp Val Tyr
      85                  90                  95

 tgg tgt ggg att gaa aga aga gga cct gac ctt ggg act caa gtg aaa      452
 Trp Cys Gly Ile Glu Arg Arg Gly Pro Asp Leu Gly Thr Gln Val Lys
 100                 105                 110                 115

 gtg att gtt gac cca tag ggagcg gcttcctcaa cagcaagctc acctaccaac      506
 Val Ile Val Asp Pro 
                 120

 agcaatatgg cagtgttgat cggctcccac aagaggaacc actacatgct cctggtattt    566

 gtgaaggtgc ccatcttgct catcttggtc actgccatcc tctggttgaa ggggtctcag    626

 agggtccctg aggagccagg ggaacagcct atctacatga acttctccga acctctgact    686

 aa                                                                   688




      <210> 19
      <211> 1700
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (232)..(1272)

      <220>
      <221> misc_feature
      <222> (1)...(1700)
      <223> n = a,t,c or g

      <400> 19
 tttcgtaaga ccacagaaac cctcctgtaa tggaacaagt tggctttgtt actaattgca     60

 acaaggcttt tgaaagcctt ctgtcatctt cctggggatc acctcttcag gtgtacagag    120

 acagcatagg gaaaactagg ttnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngg c atg gag     237
                                                          Met Glu
                                                            1

 aga aaa ttt atg tcc ttg caa cca tcc atc tcc gta tca gaa atg gaa      285
 Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu Met Glu
           5                  10                  15

 cca aat ggc acc ttc agc aat aac aac agc agg aac tgc aca att gaa      333
 Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr Ile Glu
      20                  25                  30

 aac ttc aag aga gaa ttt ttc cca att gta tat ctg ata ata ttt ttc      381
 Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile Phe Phe
  35                  40                  45                  50

 tgg gga gtc ttg gga aat ggg ttg tcc ata tat gtt ttc ctg cag cct      429
 Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu Gln Pro
                  55                  60                  65

 tat aag aag tcc aca tct gtg aac gtt ttc atg cta aat ctg gcc att      477
 Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu Ala Ile
              70                  75                  80

 tca gat ctc ctg ttc ata agc acg ctt ccc ttc agg gct gac tat tat      525
 Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp Tyr Tyr
          85                  90                  95

 ctt aga ggc tcc aat tgg ata ttt gga gac ctg gcc tgc agg att atg      573
 Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg Ile Met
     100                 105                 110

 tct tat tcc ttg tat gtc aac atg tac agc agt att tat ttc ctg acc      621
 Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe Leu Thr
 115                 120                 125                 130

 gtg ctg agt gtt gtg cgt ttc ctg gca atg gtt cac ccc ttt cgg ctt      669
 Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe Arg Leu
                 135                 140                 145

 ctg cat gtc acc agc atc agg agt gcc tgg atc ctc tgt ggg atc ata      717
 Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly Ile Ile
             150                 155                 160

 tgg atc ctt atc atg gct tcc tca ata atg ctc ctg gac agt ggc tct      765
 Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser Gly Ser
         165                 170                 175

 gag cag aac ggc agt gtc aca tca tgc tta gag ctg aat ctc tat aaa      813
 Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu Tyr Lys
     180                 185                 190

 att gct aag ctg cag acc atg aac tat att gcc ttg gtg gtg ggc tgc      861
 Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val Gly Cys
 195                 200                 205                 210

 ctg ctg cca ttt ttc aca ctc agc atc tgt tat ctg ctg atc att cgg      909
 Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile Ile Arg
                 215                 220                 225

 gtt ctg tta aaa gtg gag gtc cca gaa tcg ggg ctg cgg gtt tct cac      957
 Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val Ser His
             230                 235                 240

 agg aag gca ctg acc acc atc atc atc acc ttg atc atc ttc ttc ttg     1005
 Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe Phe Leu
         245                 250                 255

 tgt ttc ctg ccc tat cac aca ctg agg acc gtc cac ttg acg aca tgg     1053
 Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr Thr Trp
     260                 265                 270

 aaa gtg ggt tta tgc aaa gac aga ctg cat aaa gct ttg gtt atc aca     1101
 Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val Ile Thr
 275                 280                 285                 290

 ctg gcc ttg gca gca gcc aat gcc tgc ttc aat cct ctg ctc tat tac     1149
 Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu Tyr Tyr
                 295                 300                 305

 ttt gct ggg gag aat ttt aag gac aga cta aag tct gca ctc aga aaa     1197
 Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu Arg Lys
             310                 315                 320

 ggc cat cca cag aag gca aag aca aag tgt gtt ttc cct gtt agt gtg     1245
 Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val Ser Val
         325                 330                 335

 tgg ttg aga aag gaa aca aga gta taa ggagc tcttagatga gacctgttct     1297
 Trp Leu Arg Lys Glu Thr Arg Val 
     340                 345

 tgtatccttg tgtccatctt cattcactca taagttctcc aaatgacttt gtatttacat   1357

 cactcccaac aaatgttgat tcttaatatt tagttgacca ttacttttgt taataagacc   1417

 tacttcaaaa attttnnnnn nnnnnnnnnn nnnnnnnggg gggggccgtt ttaaaggacc   1477

 cctggggggc ccaaatttta cccgggctgg caaggaaaaa gttttttcct tatagggggc   1537

 cgttttaaaa cctacctggg aatttttgga aagaaccctt attttggggg gggaacatat   1597

 tgggccaacc tccctccaaa atttaaaggc tttagggnnn nnnnnnnntt ttaaagggaa   1657

 aagggggtaa aacaagcgga atatcctggc tgctgagaaa ttn                     1700




      <210> 20
      <211> 1671
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (417)..(1628)

      <400> 20
 tttcgtccgg aacggcggca cggggttgtt gtgggggtca gtcccccggg gactggaggg     60

 agacgcggca cgcggcctct gcgaccctat gaactctgac cccagctccc acactgtcgc    120

 ctatcaccgg cccactctcc gtgccgcgtg tcccttaaaa gctggggcct gggacaggaa    180

 cgacagacaa tgcagccaat ggcgtcacgc gcggtgcccc gctacccaat cgaaaggcgt    240

 ggctgaggga aacgcggtgg gaaccgcccc cgactccagg cgactccttg gccgggcggg    300

 ggagagcgtc cccgtcagct gagagcatcc tcactcggtc agttcctcgg gcgagttacg    360

 gggacgacct gcgggagcac gcgggcagtg gccggacgct gaagcccagg agagcg        416                                                                 
 atg gag acg tat gcg gag gtt ggg aag gag ggc aag cct tcc tgt gca      464
 Met Glu Thr Tyr Ala Glu Val Gly Lys Glu Gly Lys Pro Ser Cys Ala
   1               5                  10                  15

 tcg gtg gat ctg cag gga gac agc tcc tta cag gtg gag att tct gac      512
 Ser Val Asp Leu Gln Gly Asp Ser Ser Leu Gln Val Glu Ile Ser Asp
              20                  25                  30

 gca gtg agt gag cgg gac aag gtg aaa ttc act gtt caa aca aag agc      560
 Ala Val Ser Glu Arg Asp Lys Val Lys Phe Thr Val Gln Thr Lys Ser
          35                  40                  45

 tgc ctc cct cac ttc gcc cag acc gag ttc tca gtc gtg cgg cag cac      608
 Cys Leu Pro His Phe Ala Gln Thr Glu Phe Ser Val Val Arg Gln His
      50                  55                  60

 gag gag ttc atc tgg ctg cat gat gcc tac gtg gag aat gag gag tac      656
 Glu Glu Phe Ile Trp Leu His Asp Ala Tyr Val Glu Asn Glu Glu Tyr
  65                  70                  75                  80

 gcc ggc ctc atc atc ccc cca gcc cct ccg agg cca gac ttt gag gct      704
 Ala Gly Leu Ile Ile Pro Pro Ala Pro Pro Arg Pro Asp Phe Glu Ala
                  85                  90                  95

 tcg agg gaa aag cta cag aaa ttg ggc gag ggg gac agc tct gtc act      752
 Ser Arg Glu Lys Leu Gln Lys Leu Gly Glu Gly Asp Ser Ser Val Thr
             100                 105                 110

 cgg gaa gag ttt gcc aag atg aag cag gag ctg gaa gcg gag tac ctg      800
 Arg Glu Glu Phe Ala Lys Met Lys Gln Glu Leu Glu Ala Glu Tyr Leu
         115                 120                 125

 gcc atc ttt aag aag aca gtt gcg atg cac gaa gtc ttt ctg cag cgc      848
 Ala Ile Phe Lys Lys Thr Val Ala Met His Glu Val Phe Leu Gln Arg
     130                 135                 140

 ctg gcg gcc cac ccc acc ctg cgt cga gac cac aac ttc ttt gtg ttt      896
 Leu Ala Ala His Pro Thr Leu Arg Arg Asp His Asn Phe Phe Val Phe
 145                 150                 155                 160

 ttg gaa tat gga cag gat ctg agt gtc cgg ggg aag aac agg aag gag      944
 Leu Glu Tyr Gly Gln Asp Leu Ser Val Arg Gly Lys Asn Arg Lys Glu
                 165                 170                 175

 ctc ctc gga ggg ttt ctg agg aat att gtg aag tcc gcg gat gaa gcc      992
 Leu Leu Gly Gly Phe Leu Arg Asn Ile Val Lys Ser Ala Asp Glu Ala
             180                 185                 190

 ctc atc acg ggc atg tca ggg ctc aag gag gtg gat gac ttc ttt gag     1040
 Leu Ile Thr Gly Met Ser Gly Leu Lys Glu Val Asp Asp Phe Phe Glu
         195                 200                 205

 cat gag agg acc ttc ctg ttg gag tat cac acc cgt atc cga gat gcc     1088
 His Glu Arg Thr Phe Leu Leu Glu Tyr His Thr Arg Ile Arg Asp Ala
     210                 215                 220

 tgc ctg cgg gcc gac cgc gtc atg cgc gcc cac aag tgc ctg gca gac     1136
 Cys Leu Arg Ala Asp Arg Val Met Arg Ala His Lys Cys Leu Ala Asp
 225                 230                 235                 240

 gat tat atc cct atc tca gct gcg ctg agc agt ctg gga aca cag gaa     1184
 Asp Tyr Ile Pro Ile Ser Ala Ala Leu Ser Ser Leu Gly Thr Gln Glu
                 245                 250                 255

 gtc aac cag cta agg acg agc ttc ctc aaa ttg gca gag ctc ttt gaa     1232
 Val Asn Gln Leu Arg Thr Ser Phe Leu Lys Leu Ala Glu Leu Phe Glu
             260                 265                 270

 cgg ctg agg aag ctg gag ggc cgg gtg gct tcc gat gag gac ctg aag     1280
 Arg Leu Arg Lys Leu Glu Gly Arg Val Ala Ser Asp Glu Asp Leu Lys
         275                 280                 285

 ctg tca gac atg ctg agg tac tac atg cgt gac tca cag gca gcc aag     1328
 Leu Ser Asp Met Leu Arg Tyr Tyr Met Arg Asp Ser Gln Ala Ala Lys
     290                 295                 300

 gac ctg ctg tac cgg cgg ctg cgg gca ctg gcc gac tac gag aat gcc     1376
 Asp Leu Leu Tyr Arg Arg Leu Arg Ala Leu Ala Asp Tyr Glu Asn Ala
 305                 310                 315                 320

 aac aag gcg ctg gac aag gcg cgc acc agg aac cgg gag gtg cgg ccc     1424
 Asn Lys Ala Leu Asp Lys Ala Arg Thr Arg Asn Arg Glu Val Arg Pro
                 325                 330                 335

 gcc gag agc cac cag cag ctg tgc tgc caa cgc ttc gag cgc ctc tcc     1472
 Ala Glu Ser His Gln Gln Leu Cys Cys Gln Arg Phe Glu Arg Leu Ser
             340                 345                 350

 gac tcc gcc aag caa gag ctc atg gac ttc aag tcc cgc cgg gtc tcc     1520
 Asp Ser Ala Lys Gln Glu Leu Met Asp Phe Lys Ser Arg Arg Val Ser
         355                 360                 365

 tct ttt cga aag aat ctc att gag ctg gca gag ctg gag ctc aaa cac     1568
 Ser Phe Arg Lys Asn Leu Ile Glu Leu Ala Glu Leu Glu Leu Lys His
     370                 375                 380

 gcc aag gcc agc acc ctg att ctc cgg aac acc ctt gtt gcc cta aag     1616
 Ala Lys Ala Ser Thr Leu Ile Leu Arg Asn Thr Leu Val Ala Leu Lys
 385                 390                 395                 400

 ggg gag cct tag agt agccagagct cagccagacc ctaatctggg atctccagtg     1671
 Gly Glu Pro 






      <210> 21
      <211> 2753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2421)

      <400> 21
  atg gcg gta cgc gcg ttg aag ctg ctg acc aca ctg ctg gct gtc gtg      48
  Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val
    1               5                  10                  15

 gcc gct gcc tcc caa gcc gag gtc gag tcc gag gca gga tgg ggc atg       96
 Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met
              20                  25                  30

 gtg acg cct gat ctg ctc ttc gcc gag ggg acc gca gcc tac gcg cgc      144
 Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg
          35                  40                  45

 ggg gac tgg ccc ggg gtg gtc ctg agc atg gaa cgg gcg ctg cgc tcc      192
 Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser
      50                  55                  60

 cgg gca gcc ctc cgc gcc ctt cgc ctg cgc tgc cgc acc cag tgt gcc      240
 Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala
  65                  70                  75                  80

 gcc gac ttc ccg tgg gag ctg gac ccc gac tgg tcc ccc agc ccg gcc      288
 Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala
                  85                  90                  95

 cag gcc tcg ggc gcc gcc gcc ctg cgc gac ctg agc ttc ttc ggg ggc      336
 Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly
             100                 105                 110

 ctt ctg cgt cgc gct gcc tgc ctg cgc cgc tgc ctc ggg ccg ccg gcc      384
 Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala
         115                 120                 125

 gcc cac tcg ctc agc gaa gag atg gag ctg gag ttc cgc aag cgg agc      432
 Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser
     130                 135                 140

 ccc tac aac tac ctg cag gtc gcc tac ttc aag gtg cag acc tgc ctg      480
 Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Val Gln Thr Cys Leu
 145                 150                 155                 160

 gaa cca ggc ggc cgg ggt cct tct ggg gag agg agt gtt gca ggg gac      528
 Glu Pro Gly Gly Arg Gly Pro Ser Gly Glu Arg Ser Val Ala Gly Asp
                 165                 170                 175

 ctg agg agc ttg ggg gat cgg gga agt gtc cgc agg gag ggg aaa gtg      576
 Leu Arg Ser Leu Gly Asp Arg Gly Ser Val Arg Arg Glu Gly Lys Val
             180                 185                 190

 gcc tcc tgg ctg ggg agc tct cct cgg agc cgg gga gag ctg ctc cct      624
 Ala Ser Trp Leu Gly Ser Ser Pro Arg Ser Arg Gly Glu Leu Leu Pro
         195                 200                 205

 ggc agg aga cct tcc tcg ccc agt tcg cat ggg cag atg cta acc cca      672
 Gly Arg Arg Pro Ser Ser Pro Ser Ser His Gly Gln Met Leu Thr Pro
     210                 215                 220

 aag atc aac aag ttg gag aaa gct gtt gct gca gca cac acc ttc ttc      720
 Lys Ile Asn Lys Leu Glu Lys Ala Val Ala Ala Ala His Thr Phe Phe
 225                 230                 235                 240

 gtg ggc aat cct gag cac atg gaa atg cag cag aac cta gac tat tac      768
 Val Gly Asn Pro Glu His Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr
                 245                 250                 255

 caa acc atg tct gga gtg aag gag gcc gac ttc aag gat ctt gag act      816
 Gln Thr Met Ser Gly Val Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr
             260                 265                 270

 caa ccc cat atg caa gaa ttt cga ctg gga gtg cga ctc tac tca gag      864
 Gln Pro His Met Gln Glu Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu
         275                 280                 285

 gaa cag cca cag gaa gct gtg ccc cac cta gag gcg gcg ctg caa gaa      912
 Glu Gln Pro Gln Glu Ala Val Pro His Leu Glu Ala Ala Leu Gln Glu
     290                 295                 300

 tac ttt gtg gcc tat gag gag tgc cgt gcc ctc tgc gaa ggg ccc tat      960
 Tyr Phe Val Ala Tyr Glu Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr
 305                 310                 315                 320

 gac tac gat ggc tac aac tac ctt gag tac aac gct gac ctc ttc cag     1008
 Asp Tyr Asp Gly Tyr Asn Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln
                 325                 330                 335

 gcc atc aca gat cat tac atc cag gtc ctc aac tgt aag cag aac tgt     1056
 Ala Ile Thr Asp His Tyr Ile Gln Val Leu Asn Cys Lys Gln Asn Cys
             340                 345                 350

 gtc acg gag ctt gct tcc cac cca agt cga gag aag ccc ttt gaa gac     1104
 Val Thr Glu Leu Ala Ser His Pro Ser Arg Glu Lys Pro Phe Glu Asp
         355                 360                 365

 ttc ctc cca tcg cat tat aat tat ctg cag ttt gcc tac tat aac att     1152
 Phe Leu Pro Ser His Tyr Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile
     370                 375                 380

 ggg aat tat aca cag gct gtt gaa tgt gcc aag acc tat ctt ctc ttc     1200
 Gly Asn Tyr Thr Gln Ala Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe
 385                 390                 395                 400

 ttc ccc aat gac gag gtg atg aac caa aat ttg gcc tat tat gca gct     1248
 Phe Pro Asn Asp Glu Val Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala
                 405                 410                 415

 atg ctt gga gaa gaa cac acc aga tcc atc ggc ccc cgt gag agt gcc     1296
 Met Leu Gly Glu Glu His Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala
             420                 425                 430

 aag gag tac cga cag cga agc cta ctg gaa aaa gaa ctg ctt ttc ttc     1344
 Lys Glu Tyr Arg Gln Arg Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe
         435                 440                 445

 gct tat gat gtt ttt gga att ccc ttt gtg gat ccg gat tca tgg act     1392
 Ala Tyr Asp Val Phe Gly Ile Pro Phe Val Asp Pro Asp Ser Trp Thr
     450                 455                 460

 cca gaa gaa gtg att ccc aag aga ttg caa gag aaa cag aag tca gaa     1440
 Pro Glu Glu Val Ile Pro Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu
 465                 470                 475                 480

 cgg gaa aca gcc gta cgc atc tcc cag gag att ggg aac ctt atg aag     1488
 Arg Glu Thr Ala Val Arg Ile Ser Gln Glu Ile Gly Asn Leu Met Lys
                 485                 490                 495

 gaa atc gag acc ctt gtg gaa gag aag acc aag gag tca ctg gat gtg     1536
 Glu Ile Glu Thr Leu Val Glu Glu Lys Thr Lys Glu Ser Leu Asp Val
             500                 505                 510

 agc aga ctg acc cgg gaa ggt ggc ccc ctg ctg tat gaa ggc atc agt     1584
 Ser Arg Leu Thr Arg Glu Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser
         515                 520                 525

 ctc acc atg aac tcc aaa ctc ctg aat ggt tcc cag cgg gtg gtg atg     1632
 Leu Thr Met Asn Ser Lys Leu Leu Asn Gly Ser Gln Arg Val Val Met
     530                 535                 540

 gac ggc gta atc tct gac cac gag tgt cag gag ctg cag aga ctg acc     1680
 Asp Gly Val Ile Ser Asp His Glu Cys Gln Glu Leu Gln Arg Leu Thr
 545                 550                 555                 560

 aat gtg gca gca acc tca gga gat ggc tac cgg ggt cag acc tcc cca     1728
 Asn Val Ala Ala Thr Ser Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro
                 565                 570                 575

 cat act ccc aat gaa aag ttc tat ggt gtc act gtc ttc aaa gcc ctc     1776
 His Thr Pro Asn Glu Lys Phe Tyr Gly Val Thr Val Phe Lys Ala Leu
             580                 585                 590

 aag ctg ggg caa gaa ggc aaa gtt cct ctg cag agt gcc cac ctg tac     1824
 Lys Leu Gly Gln Glu Gly Lys Val Pro Leu Gln Ser Ala His Leu Tyr
         595                 600                 605

 tac aac gtg acg gag aag gtg cgg cgc atc atg gag tcc tac ttc cgc     1872
 Tyr Asn Val Thr Glu Lys Val Arg Arg Ile Met Glu Ser Tyr Phe Arg
     610                 615                 620

 ctg gat acg ccc ctc tac ttt tcc tac tct cat ctg gtg tgc cgc act     1920
 Leu Asp Thr Pro Leu Tyr Phe Ser Tyr Ser His Leu Val Cys Arg Thr
 625                 630                 635                 640

 gcc atc gaa gag gtc cag gca gag agg aag gat gat agt cat cca gtc     1968
 Ala Ile Glu Glu Val Gln Ala Glu Arg Lys Asp Asp Ser His Pro Val
                 645                 650                 655

 cac gtg gac aac tgc atc ctg aat gcc gag acc ctc gtg tgt gtc aaa     2016
 His Val Asp Asn Cys Ile Leu Asn Ala Glu Thr Leu Val Cys Val Lys
             660                 665                 670

 gag ccc cca gcc tac acc ttc cgc gac tac agc gcc atc ctt tac cta     2064
 Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu
         675                 680                 685

 aat ggg gac ttc gat ggc gga aac ttt tat ttc act gaa ctg gat gcc     2112
 Asn Gly Asp Phe Asp Gly Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala
     690                 695                 700

 aag acc gtg acg gca gag gtg cag cct cag tgt gga aga gcc gtg gga     2160
 Lys Thr Val Thr Ala Glu Val Gln Pro Gln Cys Gly Arg Ala Val Gly
 705                 710                 715                 720

 ttc tct tca ggc act gaa aac cca cat gga gtg aag gct gtc acc agg     2208
 Phe Ser Ser Gly Thr Glu Asn Pro His Gly Val Lys Ala Val Thr Arg
                 725                 730                 735

 ggg cag cgc tgt gcc atc gcc ctg tgg ttc acc ctg gac cct cga cac     2256
 Gly Gln Arg Cys Ala Ile Ala Leu Trp Phe Thr Leu Asp Pro Arg His
             740                 745                 750

 agc gag cgg gac agg gtg cag gca gat gac ctg gtg aag atg ctc ttc     2304
 Ser Glu Arg Asp Arg Val Gln Ala Asp Asp Leu Val Lys Met Leu Phe
         755                 760                 765

 agc cca gaa gag atg gac ctc tcc cag gag cag ccc ctg gat gcc cag     2352
 Ser Pro Glu Glu Met Asp Leu Ser Gln Glu Gln Pro Leu Asp Ala Gln
     770                 775                 780

 cag ggc ccc ccc gaa cct gca caa gag tct ctc tca ggc agt gaa tcg     2400
 Gln Gly Pro Pro Glu Pro Ala Gln Glu Ser Leu Ser Gly Ser Glu Ser
 785                 790                 795                 800

 aag ccc aag gat gag cta tga ca gcgtccaggt cagacggatg ggtgactaga     2453
 Lys Pro Lys Asp Glu Leu 
                 805

 cccatggaga ggaactcttc tgcactctga gctggccagc ccctcggggc tgcagagcag   2513

 tgagcctaca tctgccactc agccgagggg accctgctca cagccttcta catggtgcta   2573

 ctgctcttgg agtggacatg accagacacc gcaccccctg gatctggctg agggctcagg   2633

 acacaggccc agccaccccc aggggcctcc acaggccgct gcataacagc gatacagtac   2693

 ttaagtgtct gtgtagacaa ccaaagaata aatgattcat ggtttttttt aaaaaaaaaa   2753




      <210> 22
      <211> 3000
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2721)

      <400> 22
  atg gcc ctg gag cag gcg ctg cag gcg gcg cgg cag ggc gag ctg gac      48
  Met Ala Leu Glu Gln Ala Leu Gln Ala Ala Arg Gln Gly Glu Leu Asp
    1               5                  10                  15

 gtg ctg agg tcg ctg cac gcc gca ggc ctc ctg ggg ccc tcg ctg cgc       96
 Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg
              20                  25                  30

 gac ccg ctg gac gcg ctg ccc gtg cac cac gcg gcc cgc gct ggg aag      144
 Asp Pro Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ala Gly Lys
          35                  40                  45

 ctg cac tgt ctg cgc ttc ctg gtg gag gaa gcc gcc ctc ccc gcc gcg      192
 Leu His Cys Leu Arg Phe Leu Val Glu Glu Ala Ala Leu Pro Ala Ala
      50                  55                  60

 gcc cgc gcc cgc aac ggc gcc aca ccg gcc cac gac gcc tcc gcc acc      240
 Ala Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ser Ala Thr
  65                  70                  75                  80

 ggc cac ctc gcc tgc ctg cag tgg ctg ctg tcg cag ggc ggc tgc aga      288
 Gly His Leu Ala Cys Leu Gln Trp Leu Leu Ser Gln Gly Gly Cys Arg
                  85                  90                  95

 gtg cag gca ttc cct gag tcc ctg gga gtc agg gct gtg gcc ctg ggc      336
 Val Gln Ala Phe Pro Glu Ser Leu Gly Val Arg Ala Val Ala Leu Gly
             100                 105                 110

 ctg gtg cca gtc tcc tgc cgt gac aac cag gac aaa gac aat tct ggt      384
 Leu Val Pro Val Ser Cys Arg Asp Asn Gln Asp Lys Asp Asn Ser Gly
         115                 120                 125

 gcc aca gtc ttg cat ctg gct gcc cgc ttc ggc cac ccc gag gtg gtg      432
 Ala Thr Val Leu His Leu Ala Ala Arg Phe Gly His Pro Glu Val Val
     130                 135                 140

 aac tgg ctc ttg cat cat ggc ggt ggg gac ccc acc gcg gcc aca gac      480
 Asn Trp Leu Leu His His Gly Gly Gly Asp Pro Thr Ala Ala Thr Asp
 145                 150                 155                 160

 atg ggc gcc ctg cct atc cac tac gct gcc gcc aaa gga gac ttc ccc      528
 Met Gly Ala Leu Pro Ile His Tyr Ala Ala Ala Lys Gly Asp Phe Pro
                 165                 170                 175

 tcc ctg agg ctt ctc gtc gag cac tac cct gag gga gtg aat gcc caa      576
 Ser Leu Arg Leu Leu Val Glu His Tyr Pro Glu Gly Val Asn Ala Gln
             180                 185                 190

 acc aag aac ggt gcc acg ccc ctg tac ctg gcg tgc cag gag ggc cac      624
 Thr Lys Asn Gly Ala Thr Pro Leu Tyr Leu Ala Cys Gln Glu Gly His
         195                 200                 205

 ctg gag gtg acc cag tac ctg gtg cag gaa tgc ggc gca gac ccg cac      672
 Leu Glu Val Thr Gln Tyr Leu Val Gln Glu Cys Gly Ala Asp Pro His
     210                 215                 220

 gcg cgc gcc cac gac ggc atg acc ccg ctg cac gcc gcg gcg cag atg      720
 Ala Arg Ala His Asp Gly Met Thr Pro Leu His Ala Ala Ala Gln Met
 225                 230                 235                 240

 ggc cac agc cca gtc atc gtg tgg ttg gtg agc tgc acc gac gtg agc      768
 Gly His Ser Pro Val Ile Val Trp Leu Val Ser Cys Thr Asp Val Ser
                 245                 250                 255

 ctg tcc gag cag gac aaa gac ggc gcc acc gcc atg cac ttc gcg gcg      816
 Leu Ser Glu Gln Asp Lys Asp Gly Ala Thr Ala Met His Phe Ala Ala
             260                 265                 270

 agc cgc ggc cac acc aag gtg ctc agc tgg ctg ctg ctg cac ggc ggg      864
 Ser Arg Gly His Thr Lys Val Leu Ser Trp Leu Leu Leu His Gly Gly
         275                 280                 285

 gag atc tcg gct gac ctg tgg ggc ggg acc ccg ctg cac gac gcc gcc      912
 Glu Ile Ser Ala Asp Leu Trp Gly Gly Thr Pro Leu His Asp Ala Ala
     290                 295                 300

 gag aac ggg gag cta gag tgc tgc cag atc ctg gta gtg aac ggc gcg      960
 Glu Asn Gly Glu Leu Glu Cys Cys Gln Ile Leu Val Val Asn Gly Ala
 305                 310                 315                 320

 gag ctg gac gtc cgc gac cgc gac ggg tac acg gcc gcc gac ctg tcg     1008
 Glu Leu Asp Val Arg Asp Arg Asp Gly Tyr Thr Ala Ala Asp Leu Ser
                 325                 330                 335

 gac ttc aac ggc cac agc cac tgc acc cgc tac ctg cgc acg gtg gag     1056
 Asp Phe Asn Gly His Ser His Cys Thr Arg Tyr Leu Arg Thr Val Glu
             340                 345                 350

 aac ctg cac agg ggg atg gtc ctg gct ctg ggg gct gca gaa cac agc     1104
 Asn Leu His Arg Gly Met Val Leu Ala Leu Gly Ala Ala Glu His Ser
         355                 360                 365

 aag gcc cag agg cca gag gct gca ggg ggg cct gag gat gaa ctt ccc     1152
 Lys Ala Gln Arg Pro Glu Ala Ala Gly Gly Pro Glu Asp Glu Leu Pro
     370                 375                 380

 ccc gcg aaa gag tct ctg gaa gag aat gaa tgg ccc agc agg ggt cag     1200
 Pro Ala Lys Glu Ser Leu Glu Glu Asn Glu Trp Pro Ser Arg Gly Gln
 385                 390                 395                 400

 ggc ttg gtg ccc tca gca ccc act gct gtt ggc cag agc gtg gag cac     1248
 Gly Leu Val Pro Ser Ala Pro Thr Ala Val Gly Gln Ser Val Glu His
                 405                 410                 415

 cgc gtg ctt tcc cgg gat cca tcc gca gag ctg gag gct aag cag ccg     1296
 Arg Val Leu Ser Arg Asp Pro Ser Ala Glu Leu Glu Ala Lys Gln Pro
             420                 425                 430

 gat tca ggc atg tcc tca ccc aat acc acg gtg tcg gtc cag ccg ctg     1344
 Asp Ser Gly Met Ser Ser Pro Asn Thr Thr Val Ser Val Gln Pro Leu
         435                 440                 445

 aac ttt gac ctc agc tcg cct acc agc acc ctc tcc aac tac gac tcc     1392
 Asn Phe Asp Leu Ser Ser Pro Thr Ser Thr Leu Ser Asn Tyr Asp Ser
     450                 455                 460

 tgc tcc tcc agc cac tcc agc atc aag ggc cag cac cct cca tgt ggg     1440
 Cys Ser Ser Ser His Ser Ser Ile Lys Gly Gln His Pro Pro Cys Gly
 465                 470                 475                 480

 ctt tcc agc gct aga gct gca gac ata cag agc tac atg gac atg ctg     1488
 Leu Ser Ser Ala Arg Ala Ala Asp Ile Gln Ser Tyr Met Asp Met Leu
                 485                 490                 495

 aac ccg gag ctg ggc ctg cct cgg ggc acg att ggg aag ccc aca ccc     1536
 Asn Pro Glu Leu Gly Leu Pro Arg Gly Thr Ile Gly Lys Pro Thr Pro
             500                 505                 510

 cca cca ccc cca ccc agc ttc ccc ccg cca ccc ccg ccc cca ggc acc     1584
 Pro Pro Pro Pro Pro Ser Phe Pro Pro Pro Pro Pro Pro Pro Gly Thr
         515                 520                 525

 caa ctg ccc cca ccc cca cct ggc tac cca gct ccc aag cct cct gta     1632
 Gln Leu Pro Pro Pro Pro Pro Gly Tyr Pro Ala Pro Lys Pro Pro Val
     530                 535                 540

 gga cca cag gca gct gac atc tac atg cag acc aag aac aaa ctc cgc     1680
 Gly Pro Gln Ala Ala Asp Ile Tyr Met Gln Thr Lys Asn Lys Leu Arg
 545                 550                 555                 560

 cac gtg gag aca gag gcc ctc aag aag gag ctg agc tcc tgt gac ggc     1728
 His Val Glu Thr Glu Ala Leu Lys Lys Glu Leu Ser Ser Cys Asp Gly
                 565                 570                 575

 cac gac ggg ctg cgg agg cag gac tcc agc cgc aag ccc cgc gcc ttc     1776
 His Asp Gly Leu Arg Arg Gln Asp Ser Ser Arg Lys Pro Arg Ala Phe
             580                 585                 590

 agc aag cag ccc agc acg ggg gac tac tac cgg cag ctg ggc cgc tgc     1824
 Ser Lys Gln Pro Ser Thr Gly Asp Tyr Tyr Arg Gln Leu Gly Arg Cys
         595                 600                 605

 ccc ggc gag acg ctg gcc gca cgc ccg ggc atg gcg cac agc gag gag     1872
 Pro Gly Glu Thr Leu Ala Ala Arg Pro Gly Met Ala His Ser Glu Glu
     610                 615                 620

 gcg gcg ctg ctt cct ggg aac cat gtt cct aac ggc tgc gcc gcg gac     1920
 Ala Ala Leu Leu Pro Gly Asn His Val Pro Asn Gly Cys Ala Ala Asp
 625                 630                 635                 640

 ccc aag gcg tcc agg gag ctg cca ccg ccg ccc cca ccg ccg ccg ccg     1968
 Pro Lys Ala Ser Arg Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro
                 645                 650                 655

 ccc ctg ccg gag gcc gcg agt tcg cca ccg ccg gcc ccg cct ctg ccc     2016
 Pro Leu Pro Glu Ala Ala Ser Ser Pro Pro Pro Ala Pro Pro Leu Pro
             660                 665                 670

 ctc gag agc gct ggc cct ggc tgc ggg cag cgc cgc tcc tcc tcg tcc     2064
 Leu Glu Ser Ala Gly Pro Gly Cys Gly Gln Arg Arg Ser Ser Ser Ser
         675                 680                 685

 acc ggc agc acc aag tct ttc aac atg atg tcc ccg acg ggc gac aac     2112
 Thr Gly Ser Thr Lys Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn
     690                 695                 700

 tcg gag cta ctg gct gag att aag gca ggc aag agc ctg aag ccg acg     2160
 Ser Glu Leu Leu Ala Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr
 705                 710                 715                 720

 ccc cag agc aag ggg ctg acc aca gtg ttc tca ggc atc ggg cag ccg     2208
 Pro Gln Ser Lys Gly Leu Thr Thr Val Phe Ser Gly Ile Gly Gln Pro
                 725                 730                 735

 gcc ttc cag ccc gat tcg ccg ctg cct tct gtg tca cct gca ctg tca     2256
 Ala Phe Gln Pro Asp Ser Pro Leu Pro Ser Val Ser Pro Ala Leu Ser
             740                 745                 750

 cca gtc cgg agc ccc aca ccg cca gct gcg ggg ttt cag ccg ctg ctc     2304
 Pro Val Arg Ser Pro Thr Pro Pro Ala Ala Gly Phe Gln Pro Leu Leu
         755                 760                 765

 aat gga agc ttg gtt ccc gtg ccg ccc act act cct gcg ccg gga gtg     2352
 Asn Gly Ser Leu Val Pro Val Pro Pro Thr Thr Pro Ala Pro Gly Val
     770                 775                 780

 cag ctg gac gtg gag gct ctc atc ccc acg cac gat gag cag ggc cgg     2400
 Gln Leu Asp Val Glu Ala Leu Ile Pro Thr His Asp Glu Gln Gly Arg
 785                 790                 795                 800

 ccc atc ccc gag tgg aag cgc cag gtg atg gtg cgc aag atg cag ctg     2448
 Pro Ile Pro Glu Trp Lys Arg Gln Val Met Val Arg Lys Met Gln Leu
                 805                 810                 815

 aag atg cag gag gag gag gag cag agg cgg aag gag gag gag gag gag     2496
 Lys Met Gln Glu Glu Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu
             820                 825                 830

 gcc cgg ctg gcc agc atg ccc gcc tgg agg cgg gac ctc ctg cgg aag     2544
 Ala Arg Leu Ala Ser Met Pro Ala Trp Arg Arg Asp Leu Leu Arg Lys
         835                 840                 845

 aag ctg gaa gaa gag agg gag cag aag cgg aaa gag gag gag cga cag     2592
 Lys Leu Glu Glu Glu Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln
     850                 855                 860

 aag cag gag gag ctg cgg cgg gag aag gaa cag tca gag aag ctg cgg     2640
 Lys Gln Glu Glu Leu Arg Arg Glu Lys Glu Gln Ser Glu Lys Leu Arg
 865                 870                 875                 880

 acg ctg ggc tac gat gag agc aag ctg gcg ccc tgg cag cga cag gtc     2688
 Thr Leu Gly Tyr Asp Glu Ser Lys Leu Ala Pro Trp Gln Arg Gln Val
                 885                 890                 895

 atc ctg aag aag ggg gac atc gct aag tac tag aggccgca gactcctgtc     2739
 Ile Leu Lys Lys Gly Asp Ile Ala Lys Tyr 
             900                 905

 cgcagcctcg cagctccgtg gggccctccg ccccagcccc agccagccag gccctggtgg   2799

 aaaggctggg agccgcacag ccctcccctc ctgcgctgga aaccctccct gacccccacc   2859

 ctggcccccc gtatccccag cccttggcaa cactggagtg cacacgccgc cacggttgcc   2919

 cagaaaaagt gcccaagctg ctgacgcaaa caacaacaaa tgctgcttat ttgcatgccg   2979

 acttacaaaa aaaaaaaaaa g                                             3000




      <210> 23
      <211> 2601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2547)

      <400> 23
  atg gcc ctg gag cag gcg ctg cag gcg gcg cgg cag ggc gag ctg gac      48
  Met Ala Leu Glu Gln Ala Leu Gln Ala Ala Arg Gln Gly Glu Leu Asp
    1               5                  10                  15

 gtg ctg agg tcg ctg cac gcc gca ggc ctc ctg ggg ccc tcg ctg cgc       96
 Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg
              20                  25                  30

 gac ccg ctg gac gcg ctg ccc gtg cac cac gcg gcc cgc gct ggg aag      144
 Asp Pro Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ala Gly Lys
          35                  40                  45

 ctg cac tgt ctg cgc ttc ctg gtg gag gaa gcc gcc ctc ccc gcc gcg      192
 Leu His Cys Leu Arg Phe Leu Val Glu Glu Ala Ala Leu Pro Ala Ala
      50                  55                  60

 gcc cgc gcc cgc aac ggc gcc aca ccg gcc cac gac gcc tcc gcc acc      240
 Ala Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ser Ala Thr
  65                  70                  75                  80

 ggc cac ctc gcc tgc ctg cag tgg ctg ctg tcg cag ggc ggc tgc aga      288
 Gly His Leu Ala Cys Leu Gln Trp Leu Leu Ser Gln Gly Gly Cys Arg
                  85                  90                  95

 gtg cag gca ttc cct gag tcc ctg gga gtc agg gct gtg gcc ctg ggc      336
 Val Gln Ala Phe Pro Glu Ser Leu Gly Val Arg Ala Val Ala Leu Gly
             100                 105                 110

 ctg gtg cca gtc tcc tgc cgt gac aac cag gac aaa gac aat tct ggt      384
 Leu Val Pro Val Ser Cys Arg Asp Asn Gln Asp Lys Asp Asn Ser Gly
         115                 120                 125

 gcc aca gtc ttg cat ctg gct gcc cgc ttc ggc cac ccc gag gtg gtg      432
 Ala Thr Val Leu His Leu Ala Ala Arg Phe Gly His Pro Glu Val Val
     130                 135                 140

 aac tgg ctc ttg cat cat ggc ggt ggg gac ccc acc gcg gcc aca gac      480
 Asn Trp Leu Leu His His Gly Gly Gly Asp Pro Thr Ala Ala Thr Asp
 145                 150                 155                 160

 atg ggc gcc ctg cct atc cac tac gct gcc gcc aaa gga gac ttc ccc      528
 Met Gly Ala Leu Pro Ile His Tyr Ala Ala Ala Lys Gly Asp Phe Pro
                 165                 170                 175

 tcc ctg agg ctt ctc gtc gag cac tac cct gag gga gtg aat gcc caa      576
 Ser Leu Arg Leu Leu Val Glu His Tyr Pro Glu Gly Val Asn Ala Gln
             180                 185                 190

 acc aag aac ggt gcc acg ccc ctg tac ctg gcg tgc cag gag ggc cac      624
 Thr Lys Asn Gly Ala Thr Pro Leu Tyr Leu Ala Cys Gln Glu Gly His
         195                 200                 205

 ctg gag gtg acc cag tac ctg gtg cag gaa tgc ggc gca gac ccg cac      672
 Leu Glu Val Thr Gln Tyr Leu Val Gln Glu Cys Gly Ala Asp Pro His
     210                 215                 220

 gcg cgc gcc cac gac ggc atg acc ccg ctg cac gcc gcg gcg cag atg      720
 Ala Arg Ala His Asp Gly Met Thr Pro Leu His Ala Ala Ala Gln Met
 225                 230                 235                 240

 ggc cac agc cca gtc atc gtg tgg ttg gtg agc tgc acc gac gtg agc      768
 Gly His Ser Pro Val Ile Val Trp Leu Val Ser Cys Thr Asp Val Ser
                 245                 250                 255

 ctg tcc gag cag gac aaa gac ggc gcc acc gcc atg cac ttc gcg gcg      816
 Leu Ser Glu Gln Asp Lys Asp Gly Ala Thr Ala Met His Phe Ala Ala
             260                 265                 270

 agc cgc ggc cac acc aag gtg ctc agc tgg ctg ctg ctg cac ggc ggg      864
 Ser Arg Gly His Thr Lys Val Leu Ser Trp Leu Leu Leu His Gly Gly
         275                 280                 285

 gag atc tcg gct gac ctg tgg ggc ggg acc ccg ctg cac gac gcc gcc      912
 Glu Ile Ser Ala Asp Leu Trp Gly Gly Thr Pro Leu His Asp Ala Ala
     290                 295                 300

 gag aac ggg gag cta gag tgc tgc cag atc ctg gta gtg aac ggc gcg      960
 Glu Asn Gly Glu Leu Glu Cys Cys Gln Ile Leu Val Val Asn Gly Ala
 305                 310                 315                 320

 gag ctg gac gtc cgc gac cgc gac ggg tac acg gcc gcc gac ctg tcg     1008
 Glu Leu Asp Val Arg Asp Arg Asp Gly Tyr Thr Ala Ala Asp Leu Ser
                 325                 330                 335

 gac ttc aac ggc cac agc cac tgc acc cgc tac ctg cgc acg gtg gag     1056
 Asp Phe Asn Gly His Ser His Cys Thr Arg Tyr Leu Arg Thr Val Glu
             340                 345                 350

 aac ctg agc gtg gag cac cgc gtg ctt tcc cgg gat cca tcc gca gag     1104
 Asn Leu Ser Val Glu His Arg Val Leu Ser Arg Asp Pro Ser Ala Glu
         355                 360                 365

 ctg gag gct aag cag ccg gat tca ggc atg tcc tca ccc aat acc acg     1152
 Leu Glu Ala Lys Gln Pro Asp Ser Gly Met Ser Ser Pro Asn Thr Thr
     370                 375                 380

 gtg tcg gtc cag ccg ctg aac ttt gac ctc agc tcg cct acc agc acc     1200
 Val Ser Val Gln Pro Leu Asn Phe Asp Leu Ser Ser Pro Thr Ser Thr
 385                 390                 395                 400

 ctc tcc aac tac gac tcc tgc tcc tcc agc cac tcc agc atc aag ggc     1248
 Leu Ser Asn Tyr Asp Ser Cys Ser Ser Ser His Ser Ser Ile Lys Gly
                 405                 410                 415

 cag cac cct cca tgt ggg ctt tcc agc gct aga gct gca gac ata cag     1296
 Gln His Pro Pro Cys Gly Leu Ser Ser Ala Arg Ala Ala Asp Ile Gln
             420                 425                 430

 agc tac atg gac atg ctg aac ccg gag ctg ggc ctg cct cgg ggc acg     1344
 Ser Tyr Met Asp Met Leu Asn Pro Glu Leu Gly Leu Pro Arg Gly Thr
         435                 440                 445

 att ggg aag ccc aca ccc cca cca ccc cca ccc agc ttc ccc ccg cca     1392
 Ile Gly Lys Pro Thr Pro Pro Pro Pro Pro Pro Ser Phe Pro Pro Pro
     450                 455                 460

 ccc ccg ccc cca ggc acc caa ctg ccc cca ccc cca cct ggc tac cca     1440
 Pro Pro Pro Pro Gly Thr Gln Leu Pro Pro Pro Pro Pro Gly Tyr Pro
 465                 470                 475                 480

 gct ccc aag cct cct gta gga cca cag gca gct gac atc tac atg cag     1488
 Ala Pro Lys Pro Pro Val Gly Pro Gln Ala Ala Asp Ile Tyr Met Gln
                 485                 490                 495

 acc aag aac aaa ctc cgc cac gtg gag aca gag gcc ctc aag aag gag     1536
 Thr Lys Asn Lys Leu Arg His Val Glu Thr Glu Ala Leu Lys Lys Glu
             500                 505                 510

 ctg agc tcc tgt gac ggc cac gac ggg ctg cgg agg cag gac tcc agc     1584
 Leu Ser Ser Cys Asp Gly His Asp Gly Leu Arg Arg Gln Asp Ser Ser
         515                 520                 525

 cgc aag ccc cgc gcc ttc agc aag cag ccc agc acg ggg gac tac tac     1632
 Arg Lys Pro Arg Ala Phe Ser Lys Gln Pro Ser Thr Gly Asp Tyr Tyr
     530                 535                 540

 cgg cag ctg ggc cgc tgc ccc ggc gag acg ctg gcc gca cgc ccg ggc     1680
 Arg Gln Leu Gly Arg Cys Pro Gly Glu Thr Leu Ala Ala Arg Pro Gly
 545                 550                 555                 560

 atg gcg cac agc gag gag gcg gcg ctg ctt cct ggg aac cat gtt cct     1728
 Met Ala His Ser Glu Glu Ala Ala Leu Leu Pro Gly Asn His Val Pro
                 565                 570                 575

 aac ggc tgc gcc gcg gac ccc aag gcg tcc agg gag ctg cca ccg ccg     1776
 Asn Gly Cys Ala Ala Asp Pro Lys Ala Ser Arg Glu Leu Pro Pro Pro
             580                 585                 590

 ccc cca ccg ccg ccg ccg ccc ctg ccg gag gcc gcg agt tcg cca ccg     1824
 Pro Pro Pro Pro Pro Pro Pro Leu Pro Glu Ala Ala Ser Ser Pro Pro
         595                 600                 605

 ccg gcc ccg cct ctg ccc ctc gag agc gct ggc cct ggc tgc ggg cag     1872
 Pro Ala Pro Pro Leu Pro Leu Glu Ser Ala Gly Pro Gly Cys Gly Gln
     610                 615                 620

 cgc cgc tcc tcc tcg tcc acc ggc agc acc aag tct ttc aac atg atg     1920
 Arg Arg Ser Ser Ser Ser Thr Gly Ser Thr Lys Ser Phe Asn Met Met
 625                 630                 635                 640

 tcc ccg acg ggc gac aac tcg gag cta ctg gct gag att aag gca ggc     1968
 Ser Pro Thr Gly Asp Asn Ser Glu Leu Leu Ala Glu Ile Lys Ala Gly
                 645                 650                 655

 aag agc ctg aag ccg acg ccc cag agc aag ggg ctg acc aca gtg ttc     2016
 Lys Ser Leu Lys Pro Thr Pro Gln Ser Lys Gly Leu Thr Thr Val Phe
             660                 665                 670

 tca ggc atc ggg cag ccg gcc ttc cag ccc gat tcg ccg ctg cct tct     2064
 Ser Gly Ile Gly Gln Pro Ala Phe Gln Pro Asp Ser Pro Leu Pro Ser
         675                 680                 685

 gtg tca cct gca ctg tca cca gtc cgg agc ccc aca ccg cca gct gcg     2112
 Val Ser Pro Ala Leu Ser Pro Val Arg Ser Pro Thr Pro Pro Ala Ala
     690                 695                 700

 ggg ttt cag ccg ctg ctc aat gga agc ttg gtt ccc gtg ccg ccc act     2160
 Gly Phe Gln Pro Leu Leu Asn Gly Ser Leu Val Pro Val Pro Pro Thr
 705                 710                 715                 720

 act cct gcg ccg gga gtg cag ctg gac gtg gag gct ctc atc ccc acg     2208
 Thr Pro Ala Pro Gly Val Gln Leu Asp Val Glu Ala Leu Ile Pro Thr
                 725                 730                 735

 cac gat gag cag ggc cgg ccc atc ccc gag tgg aag cgc cag gtg atg     2256
 His Asp Glu Gln Gly Arg Pro Ile Pro Glu Trp Lys Arg Gln Val Met
             740                 745                 750

 gtg cgc aag atg cag ctg aag atg cag gag gag gag gag cag agg cgg     2304
 Val Arg Lys Met Gln Leu Lys Met Gln Glu Glu Glu Glu Gln Arg Arg
         755                 760                 765

 aag gag gag gag gag gag gcc cgg ctg gcc agc atg ccc gcc tgg agg     2352
 Lys Glu Glu Glu Glu Glu Ala Arg Leu Ala Ser Met Pro Ala Trp Arg
     770                 775                 780

 cgg gac ctc ctg cgg aag aag ctg gaa gaa gag agg gag cag aag cgg     2400
 Arg Asp Leu Leu Arg Lys Lys Leu Glu Glu Glu Arg Glu Gln Lys Arg
 785                 790                 795                 800

 aaa gag gag gag cga cag aag cag gag gag ctg cgg cgg gag aag gaa     2448
 Lys Glu Glu Glu Arg Gln Lys Gln Glu Glu Leu Arg Arg Glu Lys Glu
                 805                 810                 815

 cag tca gag aag ctg cgg acg ctg ggc tac gat gag agc aag ctg gcg     2496
 Gln Ser Glu Lys Leu Arg Thr Leu Gly Tyr Asp Glu Ser Lys Leu Ala
             820                 825                 830

 ccc tgg cag cga cag gtc atc ctg aag aag ggg gac atc gct aag tac     2544
 Pro Trp Gln Arg Gln Val Ile Leu Lys Lys Gly Asp Ile Ala Lys Tyr
         835                 840                 845

 tag aggc cgcagactcc tgtccgcagc ctcgcagctc cgtggggccc tccgccccag     2601
 






      <210> 24
      <211> 2632
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(1955)

      <400> 24
 gtcggcacaa accagcagag gcggtgacga tgctctcggg catagaggcg gcggcagggg     60

 aatatgagga ctcggagctg cggtgccgcg tggctgtgga ggagctgagc ccgggcgggc    120

 agccgcgaag gcgccaggcc ctgcgcaccg cggagctgag cctgggtcgc aactagcgcc    180

 gcgagttg atg ctg cgg ctg caa gcg cca ggg ccc gcg ggg cgg ccg cgc     230
          Met Leu Arg Leu Gln Ala Pro Gly Pro Ala Gly Arg Pro Arg
            1               5                  10

 tgc ttc cct ctg cgc gcc gcg cgc ctc ttc acg cgt ttc gcc gag gcc      278
 Cys Phe Pro Leu Arg Ala Ala Arg Leu Phe Thr Arg Phe Ala Glu Ala
  15                  20                  25                  30

 ggg cgc agc acc ctg cgg ctc ccc gcc cac gac acc ccc ggg gcc ggc      326
 Gly Arg Ser Thr Leu Arg Leu Pro Ala His Asp Thr Pro Gly Ala Gly
                  35                  40                  45

 gca gtg cag ctg ctg ctc tcg gac tgc ccc cca gac cgc ctg cgc cgc      374
 Ala Val Gln Leu Leu Leu Ser Asp Cys Pro Pro Asp Arg Leu Arg Arg
              50                  55                  60

 ttc ctg cgc aca ttg cgc ctc aag ctg gct gcg gcc ccg ggt ccc ggg      422
 Phe Leu Arg Thr Leu Arg Leu Lys Leu Ala Ala Ala Pro Gly Pro Gly
          65                  70                  75

 ccg gcc tcc gcc cga gcg cag ctg ctg ggc ccg cgg ccc cgc gac ttc      470
 Pro Ala Ser Ala Arg Ala Gln Leu Leu Gly Pro Arg Pro Arg Asp Phe
      80                  85                  90

 gtc acc atc agc cct gtg cag ccc gag gag cgg cgg ctc agg gcg gcc      518
 Val Thr Ile Ser Pro Val Gln Pro Glu Glu Arg Arg Leu Arg Ala Ala
  95                 100                 105                 110

 acc cgg gtt ccg gac act acg ctg gtg aag cgg cct gtg gag ccc cag      566
 Thr Arg Val Pro Asp Thr Thr Leu Val Lys Arg Pro Val Glu Pro Gln
                 115                 120                 125

 gct ggg gcc gag cct agc aca gaa gcc cca agg tgg ccc ctg cct gtg      614
 Ala Gly Ala Glu Pro Ser Thr Glu Ala Pro Arg Trp Pro Leu Pro Val
             130                 135                 140

 aag agg ctg agc ttg ccc tcc acc aag cca cag ctt tct gag gaa cag      662
 Lys Arg Leu Ser Leu Pro Ser Thr Lys Pro Gln Leu Ser Glu Glu Gln
         145                 150                 155

 gct gct gtg ctg agg gcc gcc ctg aaa ggc cag agc atc ttc ttc act      710
 Ala Ala Val Leu Arg Ala Ala Leu Lys Gly Gln Ser Ile Phe Phe Thr
     160                 165                 170

 ggg agt gca gga aca ggg aag tca tat ctg cta aag cga atc ctg ggc      758
 Gly Ser Ala Gly Thr Gly Lys Ser Tyr Leu Leu Lys Arg Ile Leu Gly
 175                 180                 185                 190

 tca ctg ccc ccc aca ggc act gag gcc act gcc agc act ggg gtg gca      806
 Ser Leu Pro Pro Thr Gly Thr Glu Ala Thr Ala Ser Thr Gly Val Ala
                 195                 200                 205

 gcc tgc cac atc ggg ggc acc acc ctc cat gcc ttt gca ggc atc ggc      854
 Ala Cys His Ile Gly Gly Thr Thr Leu His Ala Phe Ala Gly Ile Gly
             210                 215                 220

 tca ggc cag gct cct cta gcc cag tgt gtg gcc ctg gcc caa agg cca      902
 Ser Gly Gln Ala Pro Leu Ala Gln Cys Val Ala Leu Ala Gln Arg Pro
         225                 230                 235

 ggc gtg cgg cag ggc tgg ctg aac tgc cag cgg ttg gtc att gac gag      950
 Gly Val Arg Gln Gly Trp Leu Asn Cys Gln Arg Leu Val Ile Asp Glu
     240                 245                 250

 atc tca atg gtg gag gca gac ctg ttt gac aaa ctg gag gcc gtg gcc      998
 Ile Ser Met Val Glu Ala Asp Leu Phe Asp Lys Leu Glu Ala Val Ala
 255                 260                 265                 270

 aga gct gtc cgg cag cag aac aag cca ttc gga ggg atc cag ctc atc     1046
 Arg Ala Val Arg Gln Gln Asn Lys Pro Phe Gly Gly Ile Gln Leu Ile
                 275                 280                 285

 atc tgt ggg gac ttt ctg cag ctg cca cct gtg acc aag ggc tcc cag     1094
 Ile Cys Gly Asp Phe Leu Gln Leu Pro Pro Val Thr Lys Gly Ser Gln
             290                 295                 300

 ccc cca cgg ttc tgc ttc cag tcc aag agc tgg aag agg ggt gtg cca     1142
 Pro Pro Arg Phe Cys Phe Gln Ser Lys Ser Trp Lys Arg Gly Val Pro
         305                 310                 315

 gtg acc ctg gag ctg acc aag ggg ggg agg cag gca aac caa acc ttc     1190
 Val Thr Leu Glu Leu Thr Lys Gly Gly Arg Gln Ala Asn Gln Thr Phe
     320                 325                 330

 ttt ttt tta ctg cag gcc gtg agg cta ggc agg tgt tca gat gag gtg     1238
 Phe Phe Leu Leu Gln Ala Val Arg Leu Gly Arg Cys Ser Asp Glu Val
 335                 340                 345                 350

 acc cgc cag ctc cag gcc aca gct tcc cac aag gtg ggg cga gat ggg     1286
 Thr Arg Gln Leu Gln Ala Thr Ala Ser His Lys Val Gly Arg Asp Gly
                 355                 360                 365

 att gtg gcc acg agg ctc tgc acc cac cag gat gat gtg gcc ctc acc     1334
 Ile Val Ala Thr Arg Leu Cys Thr His Gln Asp Asp Val Ala Leu Thr
             370                 375                 380

 aac gag agg cgg ctt cag gag ctg cca ggt aag gta cac aga ttt gag     1382
 Asn Glu Arg Arg Leu Gln Glu Leu Pro Gly Lys Val His Arg Phe Glu
         385                 390                 395

 gct atg gac agc aac cct gag ctg gcc agt acc ctg gat gcc cag tgt     1430
 Ala Met Asp Ser Asn Pro Glu Leu Ala Ser Thr Leu Asp Ala Gln Cys
     400                 405                 410

 cct gtt agc cag ctc ctt caa cta aag ctg ggg gcc cag gtg atg ctg     1478
 Pro Val Ser Gln Leu Leu Gln Leu Lys Leu Gly Ala Gln Val Met Leu
 415                 420                 425                 430

 gtg aaa aac tta tcg gtg tct cgg ggc ctg gtg aat ggt gcc cga ggg     1526
 Val Lys Asn Leu Ser Val Ser Arg Gly Leu Val Asn Gly Ala Arg Gly
                 435                 440                 445

 gtg gta gtt ggg ttc gag gca gaa ggg aga ggg cta ccc cag gtg cgg     1574
 Val Val Val Gly Phe Glu Ala Glu Gly Arg Gly Leu Pro Gln Val Arg
             450                 455                 460

 ttc ctg tgt gga gtc act gag gtc atc cac gct gac cgc tgg acg gtg     1622
 Phe Leu Cys Gly Val Thr Glu Val Ile His Ala Asp Arg Trp Thr Val
         465                 470                 475

 cag gcc acc ggg ggc cag ctc ctc agt cgg cag cag ctg ccc ctc cag     1670
 Gln Ala Thr Gly Gly Gln Leu Leu Ser Arg Gln Gln Leu Pro Leu Gln
     480                 485                 490

 ctg gcc tgg gcg atg tcc atc cac aag agc caa ggc atg acc ctg gat     1718
 Leu Ala Trp Ala Met Ser Ile His Lys Ser Gln Gly Met Thr Leu Asp
 495                 500                 505                 510

 tgt gtg gag att tct ctg ggc cgt gtg ttt gcc agt ggc cag gcc tat     1766
 Cys Val Glu Ile Ser Leu Gly Arg Val Phe Ala Ser Gly Gln Ala Tyr
                 515                 520                 525

 gtg gcc ctt tct cgg gcc cgc agc ctg cag ggc cta cgt gtg ctg gac     1814
 Val Ala Leu Ser Arg Ala Arg Ser Leu Gln Gly Leu Arg Val Leu Asp
             530                 535                 540

 ttt gac ccc atg gcg gtt cgc tgt gac ccc cgt gtg ctg cac ttc tat     1862
 Phe Asp Pro Met Ala Val Arg Cys Asp Pro Arg Val Leu His Phe Tyr
         545                 550                 555

 gcc acc ctg cgg cgg ggc agg agc ctc agt ctg gag tcc cca gat gat     1910
 Ala Thr Leu Arg Arg Gly Arg Ser Leu Ser Leu Glu Ser Pro Asp Asp
     560                 565                 570

 gat gag gca gcc tca gac cag gag aac atg gac cca atc ctc tga gcc     1958
 Asp Glu Ala Ala Ser Asp Gln Glu Asn Met Asp Pro Ile Leu 
 575                 580                 585

 tcacccacaa agaggagaca aagggtggcc tgtggcctcc ccgtcctcct gctccctagt   2018

 ggcccagggc cccagggaat aactggagta ggcaggcagt gtccccttct gtatttttta   2078

 gggactctca gcctcctggc agggttaaag ggagagtact ttaaacccat ataccagctg   2138

 tgcttcagtt tctctcactt tgccctgggt aagctgctgt agggtcagaa gtaacccttt   2198

 ctgtgccagt tgagaatgag cctgtgtggt agctgatgtc agaggacaaa gctctctgca   2258

 agggctggac acagagctgc agagtcctga acatccctcc tttcaggctg cagaagggag   2318

 aggcaatgaa gacaggtgct ccggaagcag catcagggct cttggagggg actggtgggg   2378

 actcaggctg ggtgcagcct ccaaacagag aacggaactt aggtgtgtct ctacagctag   2438

 gcccagccta gcccagccca gaacaaacac ccttcagagc ctaaccaaag aacataagct   2498

 gcaaaatgtg cacccatatt ttaagctgct ttttcagggg ataaatagtg tttggggaca   2558

 ttgaaatgga tgttctcagg ttgtatttat ttcggacaaa taaactagag aattgtgtaa   2618

 aaaaaaaaaa aaag                                                     2632




      <210> 25
      <211> 1769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(1769)

      <400> 25
 gtcggcacaa accagcagag gcggtgacga tgctctcggg catagaggcg gcggcagggg     60

 aatatgagga ctcggagctg cggtgccgcg tggctgtgga ggagctgagc ccgggcgggc    120

 agccgcgaag gcgccaggcc ctgcgcaccg cggagctgag cctgggtcgc aactagcgcc    180

 gcgagttg atg ctg cgg ctg caa gcg cca ggg ccc gcg ggg cgg ccg cgc     230
          Met Leu Arg Leu Gln Ala Pro Gly Pro Ala Gly Arg Pro Arg
            1               5                  10

 tgc ttc cct ctg cgc gcc gcg cgc ctc ttc acg cgt ttc gcc gag gcc      278
 Cys Phe Pro Leu Arg Ala Ala Arg Leu Phe Thr Arg Phe Ala Glu Ala
  15                  20                  25                  30

 ggg cgc agc acc ctg cgg ctc ccc gcc cac gac acc ccc ggg gcc ggc      326
 Gly Arg Ser Thr Leu Arg Leu Pro Ala His Asp Thr Pro Gly Ala Gly
                  35                  40                  45

 gca gtg cag ctg ctg ctc tcg gac tgc ccc cca gac cgc ctg cgc cgc      374
 Ala Val Gln Leu Leu Leu Ser Asp Cys Pro Pro Asp Arg Leu Arg Arg
              50                  55                  60

 ttc ctg cgc aca ttg cgc ctc aag ctg gct gcg gcc ccg ggt ccc ggg      422
 Phe Leu Arg Thr Leu Arg Leu Lys Leu Ala Ala Ala Pro Gly Pro Gly
          65                  70                  75

 ccg gcc tcc gcc cga gcg cag ctg ctg ggc ccg cgg ccc cgc gac ttc      470
 Pro Ala Ser Ala Arg Ala Gln Leu Leu Gly Pro Arg Pro Arg Asp Phe
      80                  85                  90

 gtc acc atc agc cct gtg cag ccc gag gag cgg cgg ctc agg gcg gcc      518
 Val Thr Ile Ser Pro Val Gln Pro Glu Glu Arg Arg Leu Arg Ala Ala
  95                 100                 105                 110

 acc cgg gtt ccg gac act acg ctg gtg aag cgg cct gtg gag ccc cag      566
 Thr Arg Val Pro Asp Thr Thr Leu Val Lys Arg Pro Val Glu Pro Gln
                 115                 120                 125

 gct ggg gcc gag cct agc aca gaa gcc cca agg tgg ccc ctg cct gtg      614
 Ala Gly Ala Glu Pro Ser Thr Glu Ala Pro Arg Trp Pro Leu Pro Val
             130                 135                 140

 aag agg ctg agc ttg ccc tcc acc aag cca cag ctt tct gag gaa cag      662
 Lys Arg Leu Ser Leu Pro Ser Thr Lys Pro Gln Leu Ser Glu Glu Gln
         145                 150                 155

 gct gct gtg ctg agg gcc gcc ctg aaa ggc cag agc atc ttc ttc act      710
 Ala Ala Val Leu Arg Ala Ala Leu Lys Gly Gln Ser Ile Phe Phe Thr
     160                 165                 170

 ggg agt gca gga aca ggg aag tca tat ctg cta aag cga atc ctg ggc      758
 Gly Ser Ala Gly Thr Gly Lys Ser Tyr Leu Leu Lys Arg Ile Leu Gly
 175                 180                 185                 190

 tca ctg ccc ccc aca ggc act gag gcc act gcc agc act ggg gtg gca      806
 Ser Leu Pro Pro Thr Gly Thr Glu Ala Thr Ala Ser Thr Gly Val Ala
                 195                 200                 205

 gcc tgc cac atc ggg ggc acc acc ctc cat gcc ttt gca ggc atc ggc      854
 Ala Cys His Ile Gly Gly Thr Thr Leu His Ala Phe Ala Gly Ile Gly
             210                 215                 220

 tca ggc cag gct cct cta gcc cag tgt gtg gcc ctg gcc caa agg cca      902
 Ser Gly Gln Ala Pro Leu Ala Gln Cys Val Ala Leu Ala Gln Arg Pro
         225                 230                 235

 ggc gtg cgg cag ggc tgg ctg aac tgc cag cgg ttg gtc att gac gag      950
 Gly Val Arg Gln Gly Trp Leu Asn Cys Gln Arg Leu Val Ile Asp Glu
     240                 245                 250

 atc tca atg gtg gag gca gac ctg ttt gac aaa ctg gag gcc gtg gcc      998
 Ile Ser Met Val Glu Ala Asp Leu Phe Asp Lys Leu Glu Ala Val Ala
 255                 260                 265                 270

 aga gct gtc cgg cag cag aac aag cca ttc gga ggg atc cag ctc atc     1046
 Arg Ala Val Arg Gln Gln Asn Lys Pro Phe Gly Gly Ile Gln Leu Ile
                 275                 280                 285

 atc tgt ggg gac ttt ctg cag ctg cca cct gtg acc aag ggc tcc cag     1094
 Ile Cys Gly Asp Phe Leu Gln Leu Pro Pro Val Thr Lys Gly Ser Gln
             290                 295                 300

 ccc cca cgg ttc tgc ttc cag tcc agc ccc aac agg tgt tca gat gag     1142
 Pro Pro Arg Phe Cys Phe Gln Ser Ser Pro Asn Arg Cys Ser Asp Glu
         305                 310                 315

 gtg acc cgc cag ctc cag gcc aca gct tcc cac aag gtg ggg cga gat     1190
 Val Thr Arg Gln Leu Gln Ala Thr Ala Ser His Lys Val Gly Arg Asp
     320                 325                 330

 ggg att gtg gcc acg agg ctc tgc acc cac cag gat gat gtg gcc ctc     1238
 Gly Ile Val Ala Thr Arg Leu Cys Thr His Gln Asp Asp Val Ala Leu
 335                 340                 345                 350

 acc aac gag agg cgg ctt cag gag ctg cca ggt aag gta cac aga ttt     1286
 Thr Asn Glu Arg Arg Leu Gln Glu Leu Pro Gly Lys Val His Arg Phe
                 355                 360                 365

 gag gct atg gac agc aac cct gag ctg gcc agt acc ctg gat gcc cag     1334
 Glu Ala Met Asp Ser Asn Pro Glu Leu Ala Ser Thr Leu Asp Ala Gln
             370                 375                 380

 tgt cct gtt agc cag ctc ctt caa cta aag ctg ggg gcc cag gtg atg     1382
 Cys Pro Val Ser Gln Leu Leu Gln Leu Lys Leu Gly Ala Gln Val Met
         385                 390                 395

 ctg gtg aaa aac tta tcg gtg tct cgg ggc ctg gtg aat ggt gcc cga     1430
 Leu Val Lys Asn Leu Ser Val Ser Arg Gly Leu Val Asn Gly Ala Arg
     400                 405                 410

 ggg gtg gta gtt ggg ttc gag gca gaa ggg aga ggg cta ccc cag gtg     1478
 Gly Val Val Val Gly Phe Glu Ala Glu Gly Arg Gly Leu Pro Gln Val
 415                 420                 425                 430

 cgg ttc ctg tgt gga gtc act gag gtc atc cac gct gac cgc tgg acg     1526
 Arg Phe Leu Cys Gly Val Thr Glu Val Ile His Ala Asp Arg Trp Thr
                 435                 440                 445

 gtg cag gcc acc ggg ggc cag ctc ctc agt cgg cag cag ctg ccc ctc     1574
 Val Gln Ala Thr Gly Gly Gln Leu Leu Ser Arg Gln Gln Leu Pro Leu
             450                 455                 460

 cag ctg gcc tgg gcg atg tcc atc cac aag agc caa ggc cta cgt gtg     1622
 Gln Leu Ala Trp Ala Met Ser Ile His Lys Ser Gln Gly Leu Arg Val
         465                 470                 475

 ctg gac ttt gac ccc atg gcg gtt cgc tgt gac ccc cgt gtg ctg cac     1670
 Leu Asp Phe Asp Pro Met Ala Val Arg Cys Asp Pro Arg Val Leu His
     480                 485                 490

 ttc tat gcc acc ctg cgg cgg ggc agg agc ctc agt ctg gag tcc cca     1718
 Phe Tyr Ala Thr Leu Arg Arg Gly Arg Ser Leu Ser Leu Glu Ser Pro
 495                 500                 505                 510

 gat gat gat gag gca gcc tca gac cag gag aac atg gac cca atc ctc     1766
 Asp Asp Asp Glu Ala Ala Ser Asp Gln Glu Asn Met Asp Pro Ile Leu
                 515                 520                 525

 tga                                                                 1769
 






      <210> 26
      <211> 2023
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2023)

      <400> 26
  atg cag acc tcc agc tct aga tct gtg cac ctg agt gaa tgg cag aag      48
  Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys
    1               5                  10                  15

 aat tac ttc gca att aca tct ggc ata tgt acc gga ccg aag gca gat       96
 Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp
              20                  25                  30

 gca tac cgt gca cag ata tta cgc att cag tat gca tgg gca aac tct      144
 Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser
          35                  40                  45

 gag att tcc cag gtc tgt gct acc aaa ctg ttc aaa aaa tat gca gag      192
 Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu
      50                  55                  60

 aaa tat tct gca att att gat tct gac aat gtt gaa tct ggg ttg aat      240
 Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn
  65                  70                  75                  80

 aat tat gca gaa aac att tta act ttg gca gga tct caa caa aca gat      288
 Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp
                  85                  90                  95

 agt gac aag tgg cag tct gga ttg tca ata aat aat gtt ttc aaa atg      336
 Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met
             100                 105                 110

 agt agt gta cag aag atg atg caa gct ggc aaa aaa ttc aaa gac tct      384
 Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser
         115                 120                 125

 ctg ttg gaa cct gct ctt gca tca gtg gta atc cat aag gag gcc act      432
 Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr
     130                 135                 140

 gtc ttt gat ctt cct aaa ttt agt gtt tgt ggt agt tct caa gag agt      480
 Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser
 145                 150                 155                 160

 gac tca tta cct aac tca gct cat gat cga gac cgg acc caa gac ttc      528
 Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe
                 165                 170                 175

 ccg gag agc aat cgt ttg aaa ctc ctt cag aat gcc cag cca cct atg      576
 Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met
             180                 185                 190

 gtg act aac act gct agg act tgt cct aca ttc tca gca cct gta ggt      624
 Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly
         195                 200                 205

 gag tca gct act gca aaa ttc cat gtc aca cca ttg ttt gga aat gtc      672
 Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val
     210                 215                 220

 aaa aag gaa aat cac agc tct gca aaa gaa aac ata gga ctt aat gtg      720
 Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val
 225                 230                 235                 240

 ttc tta tct aac cag tct tgt ttt cct gct gcc tgt gaa aat cca cag      768
 Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln
                 245                 250                 255

 agg aag tct ttt tat ggt tct ggc acc att gat gca ctt tcc aat cca      816
 Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro
             260                 265                 270

 ata ctg aat aag gct tgt agt aaa aca gaa gat aat ggc cca aag gag      864
 Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu
         275                 280                 285

 gat agc agc ctg cct aca ttt aaa act gca aaa gaa caa tta tgg gta      912
 Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val
     290                 295                 300

 gat cag caa aaa aag tac cac caa cct cag cgt gca tca ggg tct tca      960
 Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser
 305                 310                 315                 320

 tat ggt ggt gta aaa aag tct cta gga gct agt aga tcc cga ggg ata     1008
 Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile
                 325                 330                 335

 ctt gga aag ttt gtt cct cct ata ccc aag caa gat ggg gga gag cag     1056
 Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln
             340                 345                 350

 aat gga gga atg caa tgt aag cct tat ggg gca gga cct aca gaa cca     1104
 Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro
         355                 360                 365

 gca cat cca gtt gat gag cgt ctg aag aac ttg gag cca aag atg att     1152
 Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile
     370                 375                 380

 gaa ctt att atg aat gag att atg gat cat gga cct cca gta aat tgg     1200
 Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp
 385                 390                 395                 400

 gaa gat att gca gga gta gaa ttt gct aaa gcc acc ata aag gaa ata     1248
 Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile
                 405                 410                 415

 gtt gtg tgg ccc atg ttg agg cca gac atc ttt act ggt tta agg gga     1296
 Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly
             420                 425                 430

 ccc cct aaa gga att ttg ctc ttt ggt cct cct ggg act ggt aaa act     1344
 Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr
         435                 440                 445

 cta att ggc aag tgc att gct agt cag tct ggg gca aca ttc ttt agc     1392
 Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser
     450                 455                 460

 atc tct gct tca tcc tta act tct aaa tgg gta ggt gag ggg gag aaa     1440
 Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys
 465                 470                 475                 480

 atg gtc cgt gca ttg ttt gct gtt gca agg tgt cag caa cca gct gtg     1488
 Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val
                 485                 490                 495

 ata ttt att gac gaa att gat tcc ttg tta tct caa cgg gga gat ggt     1536
 Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly
             500                 505                 510

 gag cat gaa tct tct aga agg ata aaa aca gaa ttt tta gtt caa tta     1584
 Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu
         515                 520                 525

 gat gga gca aca aca tct tct gaa gat cgt atc cta gtg gtg gga gca     1632
 Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala
     530                 535                 540

 aca aat cgg cca caa gaa att gat gag gct gcc cgg aga aga ttg gtg     1680
 Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val
 545                 550                 555                 560

 aaa agg ctt tat att ccc ctc cca gaa gct tca gcc agg aaa cag ata     1728
 Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile
                 565                 570                 575

 gta att aat cta atg tcc aaa gag cag tgt tgc ctc agt gaa gaa gaa     1776
 Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu
             580                 585                 590

 att gaa cag att gta cag cag tct gat gcg ttt tca gga gca gac atg     1824
 Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met
         595                 600                 605

 aca cag ctt tgc agg gag gct tct ctt ggt cct att cgc agt tta caa     1872
 Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln
     610                 615                 620

 act gct gac att gct acc ata aca ccg gat caa gtt cga ccc ata gct     1920
 Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala
 625                 630                 635                 640

 tac att gat ttt gaa aat gct ttt aga act gtg cga cct agt gtt tct     1968
 Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser
                 645                 650                 655

 cca aaa gat tta gag ctt tat gaa aac tgg aac aaa act ttt ggt tgt     2016
 Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys
             660                 665                 670

 gga aag t                                                           2023
 Gly Lys 






      <210> 27
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(1188)

      <400> 27
 ggaattcccg ggtcgacgat ttcgtgcgac ggctgctgtg tctcctggaa agggattccc     60

 gaaaggtttt attccaaaag gagaggttgg aagacatagc tcatctcctg ctgtgtatca    120

 gccaagaagg tgtgaggtgg tgttccttgg ggatccgctt gcatctactt ggggtggttt    180

 tgaaac   atg aat ctt tcg ctc gtc ctg gct gcc ttt tgc ttg gga ata     228
          Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile
            1               5                  10

 gcc tcc gct gtt cca aaa ttt gac caa aat ttg gat aca aag tgg tac      276
 Ala Ser Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr
  15                  20                  25                  30

 cag tgg aag gca aca cac aga aga tta tat ggc gcg aat gaa gaa gga      324
 Gln Trp Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly
                  35                  40                  45

 tgg agg aga gca gtg tgg gaa aag aat atg aaa atg att gaa ctg cac      372
 Trp Arg Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His
              50                  55                  60

 aat ggg gaa tac agc caa ggg aaa cac agc ttc aca atg gcc atg aat      420
 Asn Gly Glu Tyr Ser Gln Gly Lys His Ser Phe Thr Met Ala Met Asn
          65                  70                  75

 gcc ttt gga gac atg acc aat gaa gaa ttc agg cag gtg atg aat ggt      468
 Ala Phe Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly
      80                  85                  90

 ttt caa tac cag aag cac agg aag ggg aaa cag ttc cag gaa cgc ctg      516
 Phe Gln Tyr Gln Lys His Arg Lys Gly Lys Gln Phe Gln Glu Arg Leu
  95                 100                 105                 110

 ctt ctt gag atc ccc aca tct gtg gac tgg aga gag aaa ggc tac atg      564
 Leu Leu Glu Ile Pro Thr Ser Val Asp Trp Arg Glu Lys Gly Tyr Met
                 115                 120                 125

 act cct gtg aag gat cag ggt cag tgt ggc tct tgt tgg gct ttt agt      612
 Thr Pro Val Lys Asp Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser
             130                 135                 140

 gca act ggt gct ctg gaa ggg cag atg ttc tgg aaa aca ggc aaa ctt      660
 Ala Thr Gly Ala Leu Glu Gly Gln Met Phe Trp Lys Thr Gly Lys Leu
         145                 150                 155

 atc tca ctg aat gag cag aat ctg gta gac tgc tct ggg cct caa ggc      708
 Ile Ser Leu Asn Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly
     160                 165                 170

 aat gag ggc tgc aat ggt gac ttc atg gat aat ccc ttc cgg tat gtt      756
 Asn Glu Gly Cys Asn Gly Asp Phe Met Asp Asn Pro Phe Arg Tyr Val
 175                 180                 185                 190

 cag gag aac gga ggc ctg gac tct gag gaa tcc tat cca tat gag gca      804
 Gln Glu Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala
                 195                 200                 205

 aca gaa gaa tcc tgt aag tac aat ccc aag tat tct gtt gct aat gac      852
 Thr Glu Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp
             210                 215                 220

 acc ggc ttt gtg gac atc cct aag cag gag aag gcc ctg atg aag gca      900
 Thr Gly Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala
         225                 230                 235

 gtt gca act gtg ggg ccc att tct gtt gct att gat gca ggt cat gag      948
 Val Ala Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu
     240                 245                 250

 tcc ttc ctg ttc tat aaa gaa ggc att tat ttt gag cca gac tgt agc      996
 Ser Phe Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser
 255                 260                 265                 270

 agt gaa gac atg gat cat ggt gtg ctg gtg gtt ggc tac gga ttt gaa     1044
 Ser Glu Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu
                 275                 280                 285

 agc aca gaa tca gat aac aat aaa tat tgg ctg gtg aag aac agc tgg     1092
 Ser Thr Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp
             290                 295                 300

 ggt gaa gaa tgg ggc atg ggt ggc tac gta aag atg gcc aaa gac cgg     1140
 Gly Glu Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg
         305                 310                 315

 aga aac cat tgt gga att gcc tca gca gcc agc tac ccc act gtg tga     1188
 Arg Asn His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
     320                 325                 330

 gctggtggac ggtgatgagg aaggacttga ctggggatgg cgcatgcatg ggaggaattc   1248

 atcttcagtc taccagcccc cgctgtgtcg gatacacact cgaatcattg aagatccgag   1308

 tgtgatttga attctgtgat attttcacac tggtaaatgt tacctctatt ttaattactg   1368

 ctataaatag gtttatatta ttgattcact tactgacttt gcattttcgt ttttaaaagg   1428

 atgtataaat ttttacctgt ttaaataaaa tttaatttca aatgtaaaaa aaaaaaaa     1486




      <210> 28
      <211> 3068
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(2512)

      <400> 28
 atgtctctgc cggacccagg ccaccggcgc agaaaacgct gccacctgga cgtcccccac     60

 ttcgcgcacg cactctggtg cttgcatata aataaccccg ggcccggccc cggccccccg    120

 ccaagcc  atg ctg tgc ggc cgc tgg agg cgt tgc cgc cgc ccg ccc gag     169
          Met Leu Cys Gly Arg Trp Arg Arg Cys Arg Arg Pro Pro Glu
            1               5                  10

 gag ccc cca gtg gcc gcc cag gtc gca gcc caa gtc gcg gcg ccg gtc      217
 Glu Pro Pro Val Ala Ala Gln Val Ala Ala Gln Val Ala Ala Pro Val
  15                  20                  25                  30

 gct ctc ccg tcc ccg ccg act ccc tcc gat ggc ggc acc aag agg ccc      265
 Ala Leu Pro Ser Pro Pro Thr Pro Ser Asp Gly Gly Thr Lys Arg Pro
                  35                  40                  45

 ggg ctg cgg gcg ctg aag aag atg ggc ctg acg gag gac gag gac gtg      313
 Gly Leu Arg Ala Leu Lys Lys Met Gly Leu Thr Glu Asp Glu Asp Val
              50                  55                  60

 cgc gcc atg ctg cgg ggc tcc cgg ctc cgc aag atc cgc tcg cgc acg      361
 Arg Ala Met Leu Arg Gly Ser Arg Leu Arg Lys Ile Arg Ser Arg Thr
          65                  70                  75

 tgg cac aag gag cgg ctg tac cgg ctg cag gag gac ggc ctg agc gtg      409
 Trp His Lys Glu Arg Leu Tyr Arg Leu Gln Glu Asp Gly Leu Ser Val
      80                  85                  90

 tgg ttc cag cgg cgc atc ccg cgt gcg cca tcg cag cac atc ttc ttc      457
 Trp Phe Gln Arg Arg Ile Pro Arg Ala Pro Ser Gln His Ile Phe Phe
  95                 100                 105                 110

 gtg cag cac atc gag gcg gtc cgc gag ggc cac cag tcc gag ggc ctg      505
 Val Gln His Ile Glu Ala Val Arg Glu Gly His Gln Ser Glu Gly Leu
                 115                 120                 125

 cgg cgc ttc ggg ggt gcc ttc gcg cca gcg cgc tgc ctc acc atc gcc      553
 Arg Arg Phe Gly Gly Ala Phe Ala Pro Ala Arg Cys Leu Thr Ile Ala
             130                 135                 140

 ttc aag ggc cgc cgc aag aac ctg gac ctg gcg gcg ccc acg gct gag      601
 Phe Lys Gly Arg Arg Lys Asn Leu Asp Leu Ala Ala Pro Thr Ala Glu
         145                 150                 155

 gaa gcg cag cgc tgg gtg cgc ggt ctg acc aag ctc cgc gcg cgc ctg      649
 Glu Ala Gln Arg Trp Val Arg Gly Leu Thr Lys Leu Arg Ala Arg Leu
     160                 165                 170

 gac gcc atg agc cag cgc gag cgg cta gac cac tgg atc cac tcc tat      697
 Asp Ala Met Ser Gln Arg Glu Arg Leu Asp His Trp Ile His Ser Tyr
 175                 180                 185                 190

 ctg cac cgg gct gac tcc aac cag gac agc aag atg agc ttc aag gag      745
 Leu His Arg Ala Asp Ser Asn Gln Asp Ser Lys Met Ser Phe Lys Glu
                 195                 200                 205

 atc aag agc ctg ctg aga atg gtc aac gtg gac atg aac gac atg tac      793
 Ile Lys Ser Leu Leu Arg Met Val Asn Val Asp Met Asn Asp Met Tyr
             210                 215                 220

 gcc tac ctc ctc ttc aag gag tgt gac cac tcc aac aac gac cgt cta      841
 Ala Tyr Leu Leu Phe Lys Glu Cys Asp His Ser Asn Asn Asp Arg Leu
         225                 230                 235

 gag ggg gct gag atc gag gag ttc ctg cgg cgg ctg ctg aag cgg ccg      889
 Glu Gly Ala Glu Ile Glu Glu Phe Leu Arg Arg Leu Leu Lys Arg Pro
     240                 245                 250

 gag ctg gag gag atc ttc cat cag tac tcg ggc gag gac cgc gtg ctg      937
 Glu Leu Glu Glu Ile Phe His Gln Tyr Ser Gly Glu Asp Arg Val Leu
 255                 260                 265                 270

 agt gcc cct gag ctg ctg gag ttc ctg gag gac cag ggc gag gag ggc      985
 Ser Ala Pro Glu Leu Leu Glu Phe Leu Glu Asp Gln Gly Glu Glu Gly
                 275                 280                 285

 gcc aca ctg gcc cgc gcc cag cag ctc att cag acc tat gag ctc aac     1033
 Ala Thr Leu Ala Arg Ala Gln Gln Leu Ile Gln Thr Tyr Glu Leu Asn
             290                 295                 300

 gag aca gcc aag cag cat gag ctg atg aca ctg gat ggc ttc atg atg     1081
 Glu Thr Ala Lys Gln His Glu Leu Met Thr Leu Asp Gly Phe Met Met
         305                 310                 315

 tac ctg ttg tcg ccg gag ggg gct gcc ttg gac aac acc cac acg tgt     1129
 Tyr Leu Leu Ser Pro Glu Gly Ala Ala Leu Asp Asn Thr His Thr Cys
     320                 325                 330

 gtg ttc cag gac atg aac cag ccc ctt gcc cac tac ttc atc tct tcc     1177
 Val Phe Gln Asp Met Asn Gln Pro Leu Ala His Tyr Phe Ile Ser Ser
 335                 340                 345                 350

 tcc cac aac acc tat ctg act gac tcc cag atc ggg ggg ccc agc agc     1225
 Ser His Asn Thr Tyr Leu Thr Asp Ser Gln Ile Gly Gly Pro Ser Ser
                 355                 360                 365

 acc gag gcc tat gtt agg tac tgt agc agg ggg gcc ttt gcc cag gga     1273
 Thr Glu Ala Tyr Val Arg Tyr Cys Ser Arg Gly Ala Phe Ala Gln Gly
             370                 375                 380

 tgc cgc tgc gtg gag ctg gac tgc tgg gag ggg cca gga ggg gag ccc     1321
 Cys Arg Cys Val Glu Leu Asp Cys Trp Glu Gly Pro Gly Gly Glu Pro
         385                 390                 395

 gtc atc tat cat ggc cat acc ctc acc tcc aag att ctc ttc cgg gac     1369
 Val Ile Tyr His Gly His Thr Leu Thr Ser Lys Ile Leu Phe Arg Asp
     400                 405                 410

 gtg gtc caa gcc gtg cgc gac cat gcc ttc acg ctg tcc cct tac cct     1417
 Val Val Gln Ala Val Arg Asp His Ala Phe Thr Leu Ser Pro Tyr Pro
 415                 420                 425                 430

 gtc atc cta tcc ctg gag aac cac tgc ggg ctg gag cag cag gct gcc     1465
 Val Ile Leu Ser Leu Glu Asn His Cys Gly Leu Glu Gln Gln Ala Ala
                 435                 440                 445

 atg gcc cgc cac ctc tgc acc atc ctg ggg gac atg ctg gtg aca cag     1513
 Met Ala Arg His Leu Cys Thr Ile Leu Gly Asp Met Leu Val Thr Gln
             450                 455                 460

 gcg ctg gac tcc cca aat ccc gag gag ctg cca tcc cca gag cag ctg     1561
 Ala Leu Asp Ser Pro Asn Pro Glu Glu Leu Pro Ser Pro Glu Gln Leu
         465                 470                 475

 aag ggc cgg gtc ctg gtg aag gga aag aag ctg ccc gct gct cgg agc     1609
 Lys Gly Arg Val Leu Val Lys Gly Lys Lys Leu Pro Ala Ala Arg Ser
     480                 485                 490

 gag gat ggc cgg gct ctg tcg gat cgg gag gag gag gag gag gat gac     1657
 Glu Asp Gly Arg Ala Leu Ser Asp Arg Glu Glu Glu Glu Glu Asp Asp
 495                 500                 505                 510

 gag gag gaa gaa gag gag gtg gag gct gca gcg cag agg cgg ctg gcc     1705
 Glu Glu Glu Glu Glu Glu Val Glu Ala Ala Ala Gln Arg Arg Leu Ala
                 515                 520                 525

 aag cag atc tcc ccg gag ctg tcg gcc ctg gct gtg tac tgc cac gcc     1753
 Lys Gln Ile Ser Pro Glu Leu Ser Ala Leu Ala Val Tyr Cys His Ala
             530                 535                 540

 acc cgc ctg cgg acc ctg cac cct gcc ccc aac gcc cca caa ccc tgc     1801
 Thr Arg Leu Arg Thr Leu His Pro Ala Pro Asn Ala Pro Gln Pro Cys
         545                 550                 555

 cag gtc agc tcc ctc agc gag cgc aaa gcc aag aaa ctc att cgg gag     1849
 Gln Val Ser Ser Leu Ser Glu Arg Lys Ala Lys Lys Leu Ile Arg Glu
     560                 565                 570

 gca ggg aac agc ttt gtc agg cac aat gcc cgc cag ctg acc cgc gtg     1897
 Ala Gly Asn Ser Phe Val Arg His Asn Ala Arg Gln Leu Thr Arg Val
 575                 580                 585                 590

 tac ccg ctg ggg ctg cgg atg aac tca gcc aac tac agt ccc cag gag     1945
 Tyr Pro Leu Gly Leu Arg Met Asn Ser Ala Asn Tyr Ser Pro Gln Glu
                 595                 600                 605

 atg tgg aac tcg ggc tgt cag ctg gtg gcc ttg aac ttc cag acg cca     1993
 Met Trp Asn Ser Gly Cys Gln Leu Val Ala Leu Asn Phe Gln Thr Pro
             610                 615                 620

 ggc tac gag atg gac ctc aat gcc ggg cgc ttc cta gtc aat ggg cag     2041
 Gly Tyr Glu Met Asp Leu Asn Ala Gly Arg Phe Leu Val Asn Gly Gln
         625                 630                 635

 tgt ggc tac gtc cta aaa cct gcc tgc ctg cgg caa cct gac tcg acc     2089
 Cys Gly Tyr Val Leu Lys Pro Ala Cys Leu Arg Gln Pro Asp Ser Thr
     640                 645                 650

 ttt gac ccc gag tac cca gga cct ccc aga acc act ctc agc atc cag     2137
 Phe Asp Pro Glu Tyr Pro Gly Pro Pro Arg Thr Thr Leu Ser Ile Gln
 655                 660                 665                 670

 gtg ctg act gca cag cag ctg ccc aag ctg aat gcc gag aag cca cac     2185
 Val Leu Thr Ala Gln Gln Leu Pro Lys Leu Asn Ala Glu Lys Pro His
                 675                 680                 685

 tcc att gtg gac ccc ctg gtg cgc att gag atc cat ggg gtg ccc gca     2233
 Ser Ile Val Asp Pro Leu Val Arg Ile Glu Ile His Gly Val Pro Ala
             690                 695                 700

 gac tgt gcc cgg cag gag act gac tac gtg ctc aac aat ggc ttc aac     2281
 Asp Cys Ala Arg Gln Glu Thr Asp Tyr Val Leu Asn Asn Gly Phe Asn
         705                 710                 715

 ccc cgc tgg ggg cag acc ctg cag ttc cag ctg cgg gct ccg gag ctg     2329
 Pro Arg Trp Gly Gln Thr Leu Gln Phe Gln Leu Arg Ala Pro Glu Leu
     720                 725                 730

 gca ctg gtc cgg ttt gtg gtg gaa gat tat gac gcc acc tcc ccc aat     2377
 Ala Leu Val Arg Phe Val Val Glu Asp Tyr Asp Ala Thr Ser Pro Asn
 735                 740                 745                 750

 gac ttt gtg ggc cag ttt aca ctg cct ctt agc agc cta aag caa ggg     2425
 Asp Phe Val Gly Gln Phe Thr Leu Pro Leu Ser Ser Leu Lys Gln Gly
                 755                 760                 765

 tac cgc cac ata cac ctg ctt tcc aag gac ggg gcc tca ctg tca cca     2473
 Tyr Arg His Ile His Leu Leu Ser Lys Asp Gly Ala Ser Leu Ser Pro
             770                 775                 780

 gcc acg ctc ttc atc caa atc cgc atc cag cgc tcc tga gggcccacct      2522
 Ala Thr Leu Phe Ile Gln Ile Arg Ile Gln Arg Ser 
         785                 790

 cactcgcctt ggggttctgc gagtgccagt ccacatcccc tgcagagccc tctcctcctc   2582

 tggagtcagg tggtgggagt accagccccc cagcccaccc acttggccca ctcagcccat   2642

 tcaccaggcg ctggtctcac ctgggtgctg agggctgcct gggcccctcc tgaagaacag   2702

 aaaggtgttc atgtgacttc agtgagctcc aaccctgggg ccctgagatg gccccagctc   2762

 ctcttgtcct cagcccaccc ctcattgtga cttatgagga gcaagcctgt tgctgccagg   2822

 agacttgggg agcaggacac ttgtgggccc tcagttcccc tctgtcctcc cgtgggccat   2882

 cccagcctcc ttcccccaga ggagcgcagt cactccactt ggccccgacc ccgagcttag   2942

 cccctaagcc ctcctttacc ccaggccttc ctggactcct ccctccagct ccggaacctg   3002

 agctcccctt cccttctcaa agcaagaagg gagcgctgag gcatgaagcc ctggggaaac   3062

 tggcag                                                              3068




      <210> 29
      <211> 1413
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (229)..(1089)

      <400> 29
 ccatacggca tatatcttag ggtggaagat ggataaataa ttctgtcaca cgtgccctgg     60

 cctctggagc tcagctgcca gtccacgtct agggaatctt agcatctggg accaagacac    120

 tttacagcaa tcatcaccct ttgcagagga ggtgagctca ccaggactca tctgccattt    180

 cagacctttt gctgctacct gccaggtggc ccccactgct gacgagag atg gtg gat     237
                                                      Met Val Asp
                                                        1

 ctc tca gtc tcc ccg gac tcc ttg aag cca gta tcg ctg acc agc agt      285
 Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu Thr Ser Ser
       5                  10                  15

 ctt gtc ttc ctc atg cac ctc ctc ctc ctt cag cct ggg gag ccg agc      333
 Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly Glu Pro Ser
  20                  25                  30                  35

 tca gag gtc aag gtg cta ggc cct gag tat ccc atc ctg gcc ctc gtc      381
 Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu Ala Leu Val
                  40                  45                  50

 ggg gag gag gtg gag ttc ccg tgc cac cta tgg cca cag ctg gat gcc      429
 Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln Leu Asp Ala
              55                  60                  65

 cag caa atg gag atc cgc tgg ttc cgg agt cag acc ttc aat gtg gta      477
 Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe Asn Val Val
          70                  75                  80

 cac ctg tac cag gag cag cag gag ctc cct ggc agg cag atg ccg gcg      525
 His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln Met Pro Ala
      85                  90                  95

 ttc cgg aac agg acc aag ttg gtc aag gac gac atc gcc tat ggc agc      573
 Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala Tyr Gly Ser
 100                 105                 110                 115

 gtg gtc ctg cag ctt cac agc atc atc ccc tct gac aag ggc aca tat      621
 Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys Gly Thr Tyr
                 120                 125                 130

 ggc tgc cgc ttc cac tcc gac aac ttc tct ggc gaa gct ctc tgg gaa      669
 Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala Leu Trp Glu
             135                 140                 145

 ctg gag gta gca ggg ctg ggc tca gac cct cac ctc tcc ctt gag ggc      717
 Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser Leu Glu Gly
         150                 155                 160

 ttc aag gaa gga ggc att cag ctg agg ctc aga tcc agt ggc tgg tac      765
 Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser Gly Trp Tyr
     165                 170                 175

 ccc aag cct aag gtt cag tgg aga gac cac cag gga cag tgc ctg cct      813
 Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln Cys Leu Pro
 180                 185                 190                 195

 cca gag ttt gaa gcc atc gtc tgg gat gcc cag gac ctg ttc agt ctg      861
 Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu Phe Ser Leu
                 200                 205                 210

 gaa aca tct gtg gtt gtc cga gcg gga gcc ctc agc aat gtg tcc gtc      909
 Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn Val Ser Val
             215                 220                 225

 tcc atc cag aat ctc ctc ttg agc cag aag aaa gag ttg gtg gtc cag      957
 Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu Val Val Gln
         230                 235                 240

 ata gca ggt cag tgg ctg tta gct cac acc cat ctt cct agt cct cat     1005
 Ile Ala Gly Gln Trp Leu Leu Ala His Thr His Leu Pro Ser Pro His
     245                 250                 255

 gtg tac ata cac att ggc cca aag gca gtc tat aaa gag aca atg gta     1053
 Val Tyr Ile His Ile Gly Pro Lys Ala Val Tyr Lys Glu Thr Met Val
 260                 265                 270                 275

 ctg cgc ctg tct gca tat agg gtg tgt tgg cct tga cacc tgaaaattca     1103
 Leu Arg Leu Ser Ala Tyr Arg Val Cys Trp Pro 
                 280                 285

 gcaccttgga tattaggaac acactaagaa cgctactgag aacccaaaca gtcagtgaga   1163

 gaggccccag agagcccgcc tttctgtgcc taaggccata cactaaaacc catcaactct   1223

 gctcatcaga ggcatcatgg gagccaatag attcgtaatg ctgtctctca aacagtatgt   1283

 attgagtttc cacaacgtga ccccagtccc taccctcagg tccccatgcc agtgggggat   1343

 acagacaata agcaaaagaa gtgcatcctg tcacatcacg ttagaaggtg gtacgaaatc   1403

 gtcgacagca                                                          1413




      <210> 30
      <211> 2067
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (254)..(1909)

      <400> 30
 tttcgtacag agggaaggag gtggctccta gcagatgaca gacacttctc aaaagacagc     60

 ttttcttcct ggagaacaga ctttttcagc aggattttcc tttcagtgaa acataatttg    120

 acttgaaagg aacccaggga aaagtgtcca ggtgtgagca tgagcgggta gaggtgtgcc    180

 cttgtttgct tcaggctgtc tgcttttcgc ccctgactgt tttttctgtt tctggccatg    240

 gaggaagaga aag   atg aca agc cca cag gct gac ttc tgc ctg ggc acc     289
                  Met Thr Ser Pro Gln Ala Asp Phe Cys Leu Gly Thr
                    1               5                  10

 gcc ctg cac tct tgg gga ctg tgg ttc acg gag gaa ggt tca ccg tcc      337
 Ala Leu His Ser Trp Gly Leu Trp Phe Thr Glu Glu Gly Ser Pro Ser
          15                  20                  25

 acc atg ctg acg ggg att gca gtt gga gcc ctc ctg gcc ctg gcc ttg      385
 Thr Met Leu Thr Gly Ile Ala Val Gly Ala Leu Leu Ala Leu Ala Leu
      30                  35                  40

 gtt ggt gtc ctc atc ctt ttc atg ttc aga agg ctt aga caa ttt cga      433
 Val Gly Val Leu Ile Leu Phe Met Phe Arg Arg Leu Arg Gln Phe Arg
  45                  50                  55                  60

 caa gca cag ccc act cct cag tac cgg ttc cgg aag aga gac aaa gtg      481
 Gln Ala Gln Pro Thr Pro Gln Tyr Arg Phe Arg Lys Arg Asp Lys Val
                  65                  70                  75

 atg ttt tac ggc cgg aag atc atg agg aag gtg acc aca ctc ccc aac      529
 Met Phe Tyr Gly Arg Lys Ile Met Arg Lys Val Thr Thr Leu Pro Asn
              80                  85                  90

 acc ctt gtg gag aac act gcc ctg ccc cgg cag cgg gcc agg aag agg      577
 Thr Leu Val Glu Asn Thr Ala Leu Pro Arg Gln Arg Ala Arg Lys Arg
          95                 100                 105

 acc aag gtg ctg tct ttg gcc aag agg att ctg cgt ttc aag aag gaa      625
 Thr Lys Val Leu Ser Leu Ala Lys Arg Ile Leu Arg Phe Lys Lys Glu
     110                 115                 120

 tac ccg gcc ctg cag ccc aag gag ccc ccg ccc tcc ctg ctg gag gcc      673
 Tyr Pro Ala Leu Gln Pro Lys Glu Pro Pro Pro Ser Leu Leu Glu Ala
 125                 130                 135                 140

 gac ctc acg gag ttt gac gtg aag aat tct cac ctg cca tcg gaa gtt      721
 Asp Leu Thr Glu Phe Asp Val Lys Asn Ser His Leu Pro Ser Glu Val
                 145                 150                 155

 ctg tac atg ctg aaa aac gtt cgg gtc ctg ggc cac ttt gag aag ccg      769
 Leu Tyr Met Leu Lys Asn Val Arg Val Leu Gly His Phe Glu Lys Pro
             160                 165                 170

 ctg ttc ctg gag ctt tgc aaa cac atc gtc ttt gtg cag ctg cag gaa      817
 Leu Phe Leu Glu Leu Cys Lys His Ile Val Phe Val Gln Leu Gln Glu
         175                 180                 185

 ggg gag cac gtc ttc cag ccc agg gag ccg gac ccc agc atc tgt gtg      865
 Gly Glu His Val Phe Gln Pro Arg Glu Pro Asp Pro Ser Ile Cys Val
     190                 195                 200

 gtg cag gac ggg cgg ctg gag gtc tgc atc cag gac act gac ggc acc      913
 Val Gln Asp Gly Arg Leu Glu Val Cys Ile Gln Asp Thr Asp Gly Thr
 205                 210                 215                 220

 gag gtg gtg gtg aaa gag gtt ctg gcg gga gac agc gtc cac agc ctg      961
 Glu Val Val Val Lys Glu Val Leu Ala Gly Asp Ser Val His Ser Leu
                 225                 230                 235

 ctc agc atc ctg gac atc atc acc ggc cat gct gca cct tac aaa acg     1009
 Leu Ser Ile Leu Asp Ile Ile Thr Gly His Ala Ala Pro Tyr Lys Thr
             240                 245                 250

 gtc tcc gtc cgc gcg gcc atc ccg tcc acc atc ctc cgg ctt cca gct     1057
 Val Ser Val Arg Ala Ala Ile Pro Ser Thr Ile Leu Arg Leu Pro Ala
         255                 260                 265

 gcg gct ttt cat gga gtt ttt gag aaa tat ccg gaa act ctg gtg agg     1105
 Ala Ala Phe His Gly Val Phe Glu Lys Tyr Pro Glu Thr Leu Val Arg
     270                 275                 280

 gtg gtg cag atc atc atg gtg cgg ctg cag agg gtg acc ttt ctg gct     1153
 Val Val Gln Ile Ile Met Val Arg Leu Gln Arg Val Thr Phe Leu Ala
 285                 290                 295                 300

 ctg cac aac tac ctc ggc ctg acc aca gag ctc ttc aac gct gag agc     1201
 Leu His Asn Tyr Leu Gly Leu Thr Thr Glu Leu Phe Asn Ala Glu Ser
                 305                 310                 315

 cag gcc atc cct ctc gtg tct gta gcc agt gtg gct gcc ggg aag gcc     1249
 Gln Ala Ile Pro Leu Val Ser Val Ala Ser Val Ala Ala Gly Lys Ala
             320                 325                 330

 aag aag cag gtg ttc tat ggc gaa gaa gag cgg ctt aaa aag cca ccg     1297
 Lys Lys Gln Val Phe Tyr Gly Glu Glu Glu Arg Leu Lys Lys Pro Pro
         335                 340                 345

 cgg ctc cag gag tcc tgt gac tca ggt act gtc ctg cac caa gga ggg     1345
 Arg Leu Gln Glu Ser Cys Asp Ser Gly Thr Val Leu His Gln Gly Gly
     350                 355                 360

 caa tgt cca gcc cca gag tcc ggg gga tcc tgc tcc cac tgc ctc agg     1393
 Gln Cys Pro Ala Pro Glu Ser Gly Gly Ser Cys Ser His Cys Leu Arg
 365                 370                 375                 380

 tca ccc cag gtc atc ttg cac atg cct gag gcc acc aca cac atc ccc     1441
 Ser Pro Gln Val Ile Leu His Met Pro Glu Ala Thr Thr His Ile Pro
                 385                 390                 395

 ggg tca cct cac acg gcc cag gtc acc cta caa gtc cca caa gtc acc     1489
 Gly Ser Pro His Thr Ala Gln Val Thr Leu Gln Val Pro Gln Val Thr
             400                 405                 410

 tca cat gcc ccc cag gtc tac tca cac gca ccc cag gtc ccc tca cgt     1537
 Ser His Ala Pro Gln Val Tyr Ser His Ala Pro Gln Val Pro Ser Arg
         415                 420                 425

 gcc tca ggt ccc ctc aca cgt gcc cca ggt cac ctc aca tgc ccc cca     1585
 Ala Ser Gly Pro Leu Thr Arg Ala Pro Gly His Leu Thr Cys Pro Pro
     430                 435                 440

 ggt ctc atc aga tgg ccc ccc agg tct cct cac gtg tcc cca tct cct     1633
 Gly Leu Ile Arg Trp Pro Pro Arg Ser Pro His Val Ser Pro Ser Pro
 445                 450                 455                 460

 cac atg cgg gct gga tgt cct cag acc tcc cca ggt ctc atc agg tgt     1681
 His Met Arg Ala Gly Cys Pro Gln Thr Ser Pro Gly Leu Ile Arg Cys
                 465                 470                 475

 gcc cat ctc ctc aca tgt ggg ctg gat gtc ctc aaa cct cca acg gtc     1729
 Ala His Leu Leu Thr Cys Gly Leu Asp Val Leu Lys Pro Pro Thr Val
             480                 485                 490

 tca tta cgt gtg ccc gtc tcc tca cat gag gcc cgg atg tcc tca gac     1777
 Ser Leu Arg Val Pro Val Ser Ser His Glu Ala Arg Met Ser Ser Asp
         495                 500                 505

 agg ccc agg acc ctt cac cct cca ttc ttc agt tgt tcc cag aat tct     1825
 Arg Pro Arg Thr Leu His Pro Pro Phe Phe Ser Cys Ser Gln Asn Ser
     510                 515                 520

 cca ctg ggc cag gtg cct ggt ggg gag tgg gcc tcc cgc gat ggg ctc     1873
 Pro Leu Gly Gln Val Pro Gly Gly Glu Trp Ala Ser Arg Asp Gly Leu
 525                 530                 535                 540

 tca ccc gct gtt ctg agt gct aac cgg ggg gcc tga atct gaggaggaag     1923
 Ser Pro Ala Val Leu Ser Ala Asn Arg Gly Ala 
                 545                 550

 cggtcgggtg cggcgtgcac tgcatgagtc accccacgac gatctgtgtg atggagttaa   1983

 cagccaccct acagatgagg tgcgcgcttg gttatttata gcccatcatg ttcccaaaag   2043

 aattgaagtg actacaaaaa ggat                                          2067




      <210> 31
      <211> 1674
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (531)..(1517)

      <400> 31
 agagacccca ccttgtggta aagtgaaaag aagaatatgt catgtcccct atctgggaaa     60

 tcttaagcaa gagaagaaac cactgctagg ctggttatac tggctgtgac atgatggaga    120

 ggcaggggaa tcgctgaaat gacctagaag ggcctcttaa actttctggt tggaccgagc    180

 agaggaggga gagagaggtg tgtctcttgt gaggtgggtg aacgtctttt tattccctcc    240

 caatccacca acttccgccc aagccaggat ctgtcacaac tcgagaggtg gaaattccgg    300

 tttccctggc ctagagctcc cagtgctggc tttggcatga tgggcacctg gagggccgca    360

 ctcccgttcc agccaggctg agccttctgt cccctgcctc tggggcctgg gaacccccct    420

 tcttctttct cctgaatggc acccccgccc tagaatccag acaccgagtt tcccactgtg    480

 gctggttcaa gggtatgtga gagctccctg gtgacagtct gtggctgagc   atg gcc     536
                                                          Met Ala
                                                            1

 ctc cca gcc ctg ggc ctg gac ccc tgg agc ctc ctg ggc ctt ttc ctc      584
 Leu Pro Ala Leu Gly Leu Asp Pro Trp Ser Leu Leu Gly Leu Phe Leu
           5                  10                  15

 ttc caa ctg ctt cag ctg ctg ctg ccg acg acg acc gcg ggg gga ggc      632
 Phe Gln Leu Leu Gln Leu Leu Leu Pro Thr Thr Thr Ala Gly Gly Gly
      20                  25                  30

 ggg cag ggg ccc atg ccc agg gtc aga tac tat gca ggg gat gaa cgt      680
 Gly Gln Gly Pro Met Pro Arg Val Arg Tyr Tyr Ala Gly Asp Glu Arg
  35                  40                  45                  50

 agg gca ctt agc ttc ttc cac cag aag ggc ctc cag gat ttt gac act      728
 Arg Ala Leu Ser Phe Phe His Gln Lys Gly Leu Gln Asp Phe Asp Thr
                  55                  60                  65

 ctg ctc ctg agt ggt gat gga aat act ctc tac gtg ggg gct cga gaa      776
 Leu Leu Leu Ser Gly Asp Gly Asn Thr Leu Tyr Val Gly Ala Arg Glu
              70                  75                  80

 gcc att ctg gcc ttg gat atc cag gat cca ggg gtc ccc agg cta aag      824
 Ala Ile Leu Ala Leu Asp Ile Gln Asp Pro Gly Val Pro Arg Leu Lys
          85                  90                  95

 aac atg ata ccg tgg cca gcc agt gac aga aaa aag agt gaa tgt gcc      872
 Asn Met Ile Pro Trp Pro Ala Ser Asp Arg Lys Lys Ser Glu Cys Ala
     100                 105                 110

 ttt aag aag aag agc aat gag aca cag tgt ttc aac ttc atc cgt gtc      920
 Phe Lys Lys Lys Ser Asn Glu Thr Gln Cys Phe Asn Phe Ile Arg Val
 115                 120                 125                 130

 ctg gtt tct tac aat gtc acc cat ctc tac acc tgc ggc acc ttc gcc      968
 Leu Val Ser Tyr Asn Val Thr His Leu Tyr Thr Cys Gly Thr Phe Ala
                 135                 140                 145

 ttc agc cct gct tgt acc ttc att gaa ctt caa gat tcc tac ctg ttg     1016
 Phe Ser Pro Ala Cys Thr Phe Ile Glu Leu Gln Asp Ser Tyr Leu Leu
             150                 155                 160

 ccc atc tcg gag gac aag gtc atg gag gga aaa ggc caa agc ccc ttt     1064
 Pro Ile Ser Glu Asp Lys Val Met Glu Gly Lys Gly Gln Ser Pro Phe
         165                 170                 175

 gac ccc gct cac aag cat acg gct gtc ttg gtg gat ggg atg ctc tat     1112
 Asp Pro Ala His Lys His Thr Ala Val Leu Val Asp Gly Met Leu Tyr
     180                 185                 190

 tct ggt act atg aac aac ttc ctg ggc agt gag ccc atc ctg atg cgc     1160
 Ser Gly Thr Met Asn Asn Phe Leu Gly Ser Glu Pro Ile Leu Met Arg
 195                 200                 205                 210

 aca ctg gga tcc cag cct gtc ctc aag acc gac aac ttc ctc cgc tgg     1208
 Thr Leu Gly Ser Gln Pro Val Leu Lys Thr Asp Asn Phe Leu Arg Trp
                 215                 220                 225

 ctg cat cat gac gcc tcc ttt gtg gca gcc atc cct tcg acc cag gtc     1256
 Leu His His Asp Ala Ser Phe Val Ala Ala Ile Pro Ser Thr Gln Val
             230                 235                 240

 gtc tac ttc ttc ttc gag gag aca gcc agc gag ttt gac ttc ttt gag     1304
 Val Tyr Phe Phe Phe Glu Glu Thr Ala Ser Glu Phe Asp Phe Phe Glu
         245                 250                 255

 agg ctc cac aca tcg cgg gtg gct aga gtc tgc aag aat gac gtg ggc     1352
 Arg Leu His Thr Ser Arg Val Ala Arg Val Cys Lys Asn Asp Val Gly
     260                 265                 270

 ggc gaa aag ctg ctg cag aag aag tgg acc acc ttc ctg aag gcc cag     1400
 Gly Glu Lys Leu Leu Gln Lys Lys Trp Thr Thr Phe Leu Lys Ala Gln
 275                 280                 285                 290

 ctg ctc tgc acc cag ccg ggg cag ctg ccc ttc aac gtc atc cgc cac     1448
 Leu Leu Cys Thr Gln Pro Gly Gln Leu Pro Phe Asn Val Ile Arg His
                 295                 300                 305

 gcg gtc ctg ctc ccc gcc gat tct ccc aca gct ccc cac atc tac gca     1496
 Ala Val Leu Leu Pro Ala Asp Ser Pro Thr Ala Pro His Ile Tyr Ala
             310                 315                 320

 gtc ttc acc tcc cag tgg tga gc agcagggctg gaccatgggg gctggacacg     1549
 Val Phe Thr Ser Gln Trp 
         325

 ggacttgacg ccagtgaggc cccagctcgt gagcggaggc aggaattgac atgagccagc   1609

 acctactcag cactttcaca taggaaggca ttaaatcgtc cccccctctc aggaaaaaaa   1669

 aaaaa                                                               1674




      <210> 32
      <211> 806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (487)..(648)

      <400> 32
 ctctgacttc tggcttgcat tgtttccagt gagaaatctg ctactatttt tatcttagtg     60

 tctctgtagt gtgtcttggt tgcttttagg attttctctt ttcattggcc ttgagtccct    120

 ccttcttccc ctcacatgtg gggactttta attccatgta tattaggctg catgaagctt    180

 ccccacaacc tactgatgct cttttcatta gaaacatttc ttactctgcg tttcattttg    240

 gatagtttct attcctatgt tttcaaaccc accaataaaa gattctgcaa catctgacct    300

 gccattaatc ccgtccagtg tatttttcat ctcctgtatt gtagttttca tctctacaat    360

 ccagcttgag cctttggtta tatcttccat gttgctcctg cactgtttga acatgcagaa    420

 tggctagtgg ggcagtgagc tgaggagaag ggacagaggg gaagctcggc tgttgggtct    480

 acgggt   atg atg gag acc atg cag ctg aaa gta aac cgt cac ccc ttc     528
          Met Met Glu Thr Met Gln Leu Lys Val Asn Arg His Pro Phe
            1               5                  10

 tgc ttc agt gtg aaa ggc cag gtg aag atg ctg cag ctg atg agg ctg      576
 Cys Phe Ser Val Lys Gly Gln Val Lys Met Leu Gln Leu Met Arg Leu
  15                  20                  25                  30

 ggc ctt agg gtg cgg ggg gtg gtg gaa tct gct tgt ggg cgg gag atg      624
 Gly Leu Arg Val Arg Gly Val Val Glu Ser Ala Cys Gly Arg Glu Met
                  35                  40                  45

 tgg cta tgt ggc tat aaa gga tga agatgaacgc cctgtttgct tttcagcctc     678
 Trp Leu Cys Gly Tyr Lys Gly 
              50

 gcttggatca aggttaaaag gccggttgtg gccttcttgg tggaagaaag agagagataa    738

 ggcactgtcc tccccttcgg agggtctggg gatacactaa tccatcaaaa ccactgaggg    798

 ctgggcgt                                                             806




      <210> 33
      <211> 1526
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (684)..(1016)

      <400> 33
 tcagtcagat aagccaaaac tccggaataa ggcaaagctg gtacgcccgc ggggaccgct     60

 ttttaattcc cttttcgacg aattcgtgcg gggagaatgg tggctgcttt tgaatttcct    120

 gactctggtg gcttcactgt cacatctatg gggtgtaaag ggaggaagag tgtcgagttt    180

 tgtgccatga acagattccg tttctgcaga ggacagcgtg caggggacac ccttcgaggc    240

 tttggagcca cctaggaagc aggctggctg ctgcacaggc ctctgctggc ctccttgcac    300

 atgtccttgg tgggtgaggc agccacgtga gatggcttcc ggcactgctg gcgtgagtag    360

 ccttcctggc aatgccagct cttgccgtcc tcacctcctg gccccagtgg cccgcatgac    420

 ggctctctgt tctacacagc cctcctggtc ttcagtgccc tgggaaacat ccttgccctt    480

 tgccttacct gtcaaaagag caggaagatc aactgcacag gcatctacct ggtgcacctg    540

 gctgtgtctg acctgctgtt caccgtggcc ttaccgggaa gggtggtgtg ttatgtgctg    600

 ggctccagct ggcctttcgg caaggggctc tgcaggctga cggcgtttgt gctctacacc    660

 gacacctacg gggggtctac ctc    atg gcc tgt gtg agc gtg gac cat tac     710
                              Met Ala Cys Val Ser Val Asp His Tyr
                                1               5

 cca gct gtg gtc tgt gcc cac tgg ggc ccg tgc ctc cgc acg gct ggc      758
 Pro Ala Val Val Cys Ala His Trp Gly Pro Cys Leu Arg Thr Ala Gly
  10                  15                  20                  25

 cgc gcc agg ctg gtc tgc gtg gcc atc tgg acc ttg gtg ctg ctg cag      806
 Arg Ala Arg Leu Val Cys Val Ala Ile Trp Thr Leu Val Leu Leu Gln
                  30                  35                  40

 acg atg ccc ttg ctc ttg atg ccc atg acc aag ccg ctg gtg ggc aag      854
 Thr Met Pro Leu Leu Leu Met Pro Met Thr Lys Pro Leu Val Gly Lys
              45                  50                  55

 ctg gcc tgc atg gag tac agc agc atg gag tca gtc ctc ggg ctg ccc      902
 Leu Ala Cys Met Glu Tyr Ser Ser Met Glu Ser Val Leu Gly Leu Pro
          60                  65                  70

 ctc atg gtc ctg gtg gcc ttt gcc att ggc ttc tgt ggg cca gtg ggg      950
 Leu Met Val Leu Val Ala Phe Ala Ile Gly Phe Cys Gly Pro Val Gly
      75                  80                  85

 atc atc ctg tcc tgc tat atg aag atc acc tgg aag ctg tgc agc aca      998
 Ile Ile Leu Ser Cys Tyr Met Lys Ile Thr Trp Lys Leu Cys Ser Thr
  90                  95                 100                 105

 gct ggg aga acc cag tga ccagcg ggaaaggaca ccaccggcgg ggcagcccgg     1052
 Ala Gly Arg Thr Gln 
                 110

 gaggacccag tgaccagcag gaaaggacgc caccggcggg gcagcccagg aggacccagt   1112

 gaccagcggg aaaggacacc accagcagga cagcccgaga ggacccagtg accagcggga   1172

 aaggatgcca ccggcgggac agcccgggag gacccagtga ccagcaggaa aggacgccac   1232

 tggcgaggct gcctgcttac gctgctgatg ctggtggccg tggtggtctg cttcagcccc   1292

 taccacctca acatcaagca gttcatggcg agagggatgc tccacctgcc atcctgtgcc   1352

 gagcggaggg ctttcttact gtcccttcag gccaccgtgg ccctcatgaa catgaactgt   1412

 ggcattaccc catcatttac ttctttgcat ccacccatta caggaaatgg ctcctgggca   1472

 ttttaaagct caaagggtct tcctcctcct cctcctcctc ctccaccttg tatt         1526




      <210> 34
      <211> 1370
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (302)..(940)

      <400> 34
 tcgggtctat ccacgcatcc gaacacaagc caggtgagtc ttcatgctgg tgtttaaaag     60

 tttcctccac atcagtatag ccacgctgat gtctactctg ttgaagccag gtgcgcagtg    120

 atctactgac taatggattc tccaattgtt aagcctatgt tacaggacaa aggccgtcgc    180

 tttgtaaaag cttgaagtgc agtttgctgc tgagtacaga agacctttgc aaacagagag    240

 gggagatttt ctctgtaagg ttgcaaacaa gagcaggtcc tggaagataa gattccccgc    300

 c    atg tta tcc tcc gtg gtg ttt tgg gga cta att gcc ctc att ggc     346
      Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly
        1               5                  10                  15

 act tcc agg ggc tca tac ccc ttc agt cac tca atg aag cct cac cta      394
 Thr Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu
                  20                  25                  30

 cat cca cgc ctg tac cac ggc tgc tat ggg gac atc atg acc atg aag      442
 His Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys
              35                  40                  45

 acc tct ggg gcc act tgt gat gca aac agt gtg atg aac tgc ggg atc      490
 Thr Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile
          50                  55                  60

 cgt ggt tct gaa atg ttt gct gag atg gat ttg agg gcc ata aaa cct      538
 Arg Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro
      65                  70                  75

 tac cag act ctg atc aaa gaa gtc ggg cag aga cat tgc gtg gac cct      586
 Tyr Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro
  80                  85                  90                  95

 gct gtc atc gca gcc atc atc tcc agg gaa agc cat ggc gga tct gtc      634
 Ala Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val
                 100                 105                 110

 ctg caa gac ggc tgg gac cac agg gga ctt aaa ttt ggc ttg atg cag      682
 Leu Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln
             115                 120                 125

 ctt gat aaa caa acg tac cac cct gtc ggt gcc tgg gat agc aaa gag      730
 Leu Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu
         130                 135                 140

 cac ctt tca cag gct act ggg att cta aca gag aga att aag gca atc      778
 His Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile
     145                 150                 155

 cag aaa aaa ttc ccc acg tgg agt gtt gct cag cac ctc aaa ggt ggt      826
 Gln Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Gly
 160                 165                 170                 175

 ctc tca gct ttt aag tca gga att gaa gcg att gcc acc cca tcg gac      874
 Leu Ser Ala Phe Lys Ser Gly Ile Glu Ala Ile Ala Thr Pro Ser Asp
                 180                 185                 190

 ata gac aat gac ttc gtc aat gat atc att gct cga gct aag ttc tat      922
 Ile Asp Asn Asp Phe Val Asn Asp Ile Ile Ala Arg Ala Lys Phe Tyr
             195                 200                 205

 aaa aga caa agc ttc tag gcaaag ctctgtgggt gggccaggtt ggcagagtgc      976
 Lys Arg Gln Ser Phe 
         210

 tcagatggcc gcctttgaga gttttacgtg aatgtgttgt atacaacact ggcacagaaa   1036

 tgattaaaat catgaaagaa aattcatttc ccaattttct gaatgaaaat aatcattgaa   1096

 aaaaggaaag aaaaataaaa gaaatccatc cagttcacaa tatggttcct aggaaacgga   1156

 catagacata tatataacta ctttgcagta aatgtgaata tcatggcaaa tggtccctag   1216

 gtattccagc caggcttcat tttagcctgt gattccaatg cccacctact ccctgtctac   1276

 cagaattgct aacaagttaa gtaagcctta cccgagcctt tgtctttttt ccagtatctg   1336

 cccagagccc tcaagctttg cttatgagaa gttc                               1370




      <210> 35
      <211> 1225
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (375)..(1178)

      <400> 35
 tttcccgggt cgacgatttc gtctcagttc aatgttacca atttgggtgg tcacctaact     60

 ttccaacatg caaaggacaa gtacgatcat gtggtccacc tcctcaactc tccaatggtg    120

 aagttaagga gataagaaaa gaggaatatg gacacaatga agtagtggaa tatgattgca    180

 atcctaattt tataataaac gggcctaaga aaatacaatg cgtggatgga gaatggacaa    240

 ctttacccac ttgtgttgaa caagtgaaaa catgtggata catacctgaa ctcgagtacg    300

 gttatgttca gccgtctgtc cctccctatc aacatggagt ttcagtcgag gtgaattgca    360

 gaaatgaata tgca  atg att gga aat aac atg att acc tgt att aat gga     410
                  Met Ile Gly Asn Asn Met Ile Thr Cys Ile Asn Gly
                    1               5                  10

 ata tgg aca gag ctt cct atg tgt gtt gca aca cac caa ctt aag agg      458
 Ile Trp Thr Glu Leu Pro Met Cys Val Ala Thr His Gln Leu Lys Arg
          15                  20                  25

 tgc aaa ata gca gga gtt aat ata aaa aca tta ctc aag cta tct ggg      506
 Cys Lys Ile Ala Gly Val Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly
      30                  35                  40

 aaa gaa ttt aat cat aat tct aga ata cgt tac aga tgt tca gac atc      554
 Lys Glu Phe Asn His Asn Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile
  45                  50                  55                  60

 ttc aga tac agg cac tca gtc tgt ata aac ggg aaa tgg aat cct gaa      602
 Phe Arg Tyr Arg His Ser Val Cys Ile Asn Gly Lys Trp Asn Pro Glu
                  65                  70                  75

 gta gac tgc aca gaa aaa agg gaa caa ttc tgc cca ccg cca cct cag      650
 Val Asp Cys Thr Glu Lys Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln
              80                  85                  90

 ata cct aat gct cag aat atg aca acc aca gtg aat tat cag gat gga      698
 Ile Pro Asn Ala Gln Asn Met Thr Thr Thr Val Asn Tyr Gln Asp Gly
          95                 100                 105

 gaa aaa gta gct gtt ctc tgt aaa gaa aac tat cta ctt cca gaa gca      746
 Glu Lys Val Ala Val Leu Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala
     110                 115                 120

 aaa gaa att gta tgt aaa gat gga cga tgg caa tca tta cca cgc tgt      794
 Lys Glu Ile Val Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys
 125                 130                 135                 140

 gtt gag tct act gca tat tgt ggg ccc cct cca tct att aac aat gga      842
 Val Glu Ser Thr Ala Tyr Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly
                 145                 150                 155

 gat acc acc tca ttc cca tta tca gta tat cct cca ggg tca aca gtg      890
 Asp Thr Thr Ser Phe Pro Leu Ser Val Tyr Pro Pro Gly Ser Thr Val
             160                 165                 170

 acg tac cgt tgc cag tcc ttc tat aaa ctc cag ggc tct gta act gta      938
 Thr Tyr Arg Cys Gln Ser Phe Tyr Lys Leu Gln Gly Ser Val Thr Val
         175                 180                 185

 aca tgc aga aat aaa cag tgg tca gaa cca cca aga tgc cta gat cca      986
 Thr Cys Arg Asn Lys Gln Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro
     190                 195                 200

 tgt gtg gta tct gaa gaa aac atg aac aaa aat aac ata cag tta aaa     1034
 Cys Val Val Ser Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys
 205                 210                 215                 220

 tgg aga aac gat gga aaa ctc tat gca aaa aca ggg gat gct gtt gaa     1082
 Trp Arg Asn Asp Gly Lys Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu
                 225                 230                 235

 ttc cag tgt aaa ttc cca cat aaa gcg atg ata tca tca cca cca ttt     1130
 Phe Gln Cys Lys Phe Pro His Lys Ala Met Ile Ser Ser Pro Pro Phe
             240                 245                 250

 cga gca atc tgt cag gaa ggg aaa ttt gaa tat cct ata tgt gaa tga     1178
 Arg Ala Ile Cys Gln Glu Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
         255                 260                 265

 agcaagcata attttcctga atatattctt caaacatcca tctatgc                 1225




      <210> 36
      <211> 4397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (306)..(4397)

      <400> 36
 ccctggacct gtcccgcttg gtcacacgat gggaccctcg gcccatcagc agcgccttca     60

 actgtgaaga ggtgaactct tcaaacacgc tgagcaaaca ggcccgactc ccagggccgc    120

 atccgggatg tctcaatagc tgtggccttg acgtccacct cggacccctg ccccggaccc    180

 agcccagttc ccaatgggcc ctctgcccgg ggagcgggtc taccggcctg gatgtgaaag    240

 agagcttgga gaccccagag acctcggaac cttcagcttt ggaagtgacg tcggtggggg    300

 tcccc    atg ggg ccg gac gag gcc aca cca ccc gac ctg gtg ctt cct     347
          Met Gly Pro Asp Glu Ala Thr Pro Pro Asp Leu Val Leu Pro
            1               5                  10

 gcc tgg cgt ctg cgc cac gga gca ttc agg acg ctg gtg acc agg gag      395
 Ala Trp Arg Leu Arg His Gly Ala Phe Arg Thr Leu Val Thr Arg Glu
  15                  20                  25                  30

 cca gga gcc ccc agg atg ggt gcc ccg agc gcg tgc cgg acg ctg gtg      443
 Pro Gly Ala Pro Arg Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val
                  35                  40                  45

 ttg gct ctg gcg gcc atg ctc gtg gtg ccg cag gca gag acc cag ggc      491
 Leu Ala Leu Ala Ala Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly
              50                  55                  60

 cct gtg gag ccg agc tgg gag aat gca ggg cac acc atg gat ggc ggt      539
 Pro Val Glu Pro Ser Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly
          65                  70                  75

 gcc ccg acg tcc tcg ccc acc cgg cgc gtg agc ttt gtt cca ccc gtc      587
 Ala Pro Thr Ser Ser Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val
      80                  85                  90

 act gtc ttc ccc agc ctg agc ccc ctg aac ccg gcg cac aat ggg cgg      635
 Thr Val Phe Pro Ser Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg
  95                 100                 105                 110

 gtg tgc agc acc tgg ggt gac ttc cac tac aag acc ttc gac ggc gac      683
 Val Cys Ser Thr Trp Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp
                 115                 120                 125

 gtc ttc cgc ttc cct ggc ctt tgc aac tac gtg ttc tct gag cac tgc      731
 Val Phe Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys
             130                 135                 140

 cgc gcc gcc tac gag gac ttc aac gtc cag cta cgc cga ggc cta gtg      779
 Arg Ala Ala Tyr Glu Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val
         145                 150                 155

 ggc tcc agg cct gtg gtc acc cgt gtt gtc atc aag gcc cag ggg ctg      827
 Gly Ser Arg Pro Val Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu
     160                 165                 170

 gtg ctg gag gcg tcc aac ggc tcc gtc ctc atc aat ggg cag cgg gag      875
 Val Leu Glu Ala Ser Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu
 175                 180                 185                 190

 gag ctg cct tac agc cgc act ggc ctc ctg gtg gag cag agc ggg gac      923
 Glu Leu Pro Tyr Ser Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp
                 195                 200                 205

 tac atc aag gtc agc atc cgg ctg gtg ctg aca ttc ctg tgg aac gga      971
 Tyr Ile Lys Val Ser Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly
             210                 215                 220

 gag gac agt gcc ctg ctg gag ctg gat ccc aaa tac gcc aac cag acc     1019
 Glu Asp Ser Ala Leu Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr
         225                 230                 235

 tgt ggc ctg tgt ggg gac ttc aac ggc ctc ccg gcc ttc aac gag ttc     1067
 Cys Gly Leu Cys Gly Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe
     240                 245                 250

 tat gcc cac agt gag tgc cac ctg gac gcc agg ctg acc ccg ctc cag     1115
 Tyr Ala His Ser Glu Cys His Leu Asp Ala Arg Leu Thr Pro Leu Gln
 255                 260                 265                 270

 ttt ggg aac ctg cag aag ttg gat ggg ccc acg gag cag tgc ccg gac     1163
 Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro Thr Glu Gln Cys Pro Asp
                 275                 280                 285

 ccg ctg ccc ttg ccg gcc ggc aac tgc acg gac gag gag ggc atc tgc     1211
 Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr Asp Glu Glu Gly Ile Cys
             290                 295                 300

 cac cgc acc ctg ctg ggg ccg gcc ttt gcg gag tgc cac gca ctg gtg     1259
 His Arg Thr Leu Leu Gly Pro Ala Phe Ala Glu Cys His Ala Leu Val
         305                 310                 315

 gac agc act gcg tac ctg gcc gcc tgc gcc cag gac ctg tgc cgc tgc     1307
 Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala Gln Asp Leu Cys Arg Cys
     320                 325                 330

 ccc acc tgc ccg tgt gcc acc ttt gtg gaa tac tca cgc cag tgc gcc     1355
 Pro Thr Cys Pro Cys Ala Thr Phe Val Glu Tyr Ser Arg Gln Cys Ala
 335                 340                 345                 350

 cac gcg ggg ggc cag ccg cgg aac tgg agg tgc cct gag ctc tgc ccc     1403
 His Ala Gly Gly Gln Pro Arg Asn Trp Arg Cys Pro Glu Leu Cys Pro
                 355                 360                 365

 cgg acc tgc ccc ctc aac atg cag cac cag gag tgt ggc tca ccc tgc     1451
 Arg Thr Cys Pro Leu Asn Met Gln His Gln Glu Cys Gly Ser Pro Cys
             370                 375                 380

 acg gac acc tgc tcc aac ccc cag cgc gcg cag ctc tgt gag gac cac     1499
 Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala Gln Leu Cys Glu Asp His
         385                 390                 395

 tgt gtg gac ggc tgc ttc tgc ccc cca ggc acg gtg ctg gat gac atc     1547
 Cys Val Asp Gly Cys Phe Cys Pro Pro Gly Thr Val Leu Asp Asp Ile
     400                 405                 410

 acg cac tct ggc tgc ctg ccc ctc ggg cag tgc ccc tgc acc cac ggc     1595
 Thr His Ser Gly Cys Leu Pro Leu Gly Gln Cys Pro Cys Thr His Gly
 415                 420                 425                 430

 ggc cgc acc tac agc ccg ggc acc tcc ttc aac acc acc tgc agc tcc     1643
 Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe Asn Thr Thr Cys Ser Ser
                 435                 440                 445

 tgc acc tgc tcc ggg ggg cta tgg cag tgc cag gac ctg ccg tgc cct     1691
 Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys Gln Asp Leu Pro Cys Pro
             450                 455                 460

 ggc acc tgc tct gtg cag ggc ggg gcc cac atc tcc acc tat gat gag     1739
 Gly Thr Cys Ser Val Gln Gly Gly Ala His Ile Ser Thr Tyr Asp Glu
         465                 470                 475

 aaa ctc tac gac ctg cat ggt gac tgc agc tac gtt ctg tcc aag aaa     1787
 Lys Leu Tyr Asp Leu His Gly Asp Cys Ser Tyr Val Leu Ser Lys Lys
     480                 485                 490

 tgt gcc gac agc agc ttc acc gtg ctg gct gag ctg cgg aag tgc ggc     1835
 Cys Ala Asp Ser Ser Phe Thr Val Leu Ala Glu Leu Arg Lys Cys Gly
 495                 500                 505                 510

 ctg acg gac aac gag aac tgc ctg aaa gcg gtg acg ctc agc ctg gac     1883
 Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala Val Thr Leu Ser Leu Asp
                 515                 520                 525

 ggc ggg gac acg gcc atc cgg gtc caa gcg gac ggc ggc gtg ttc ctc     1931
 Gly Gly Asp Thr Ala Ile Arg Val Gln Ala Asp Gly Gly Val Phe Leu
             530                 535                 540

 aac tcc atc tac acg cag ctg ccc ctg tcg gca gcc aac atc acc ctg     1979
 Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser Ala Ala Asn Ile Thr Leu
         545                 550                 555

 ttc aca ccc tcg agc ttc ttc atc gtg gtg cag aca ggc ctg ggg ctg     2027
 Phe Thr Pro Ser Ser Phe Phe Ile Val Val Gln Thr Gly Leu Gly Leu
     560                 565                 570

 cag ctg ctg gtg cag ctg gtg cca ctc atg cag gtg ttt gtc agg ctg     2075
 Gln Leu Leu Val Gln Leu Val Pro Leu Met Gln Val Phe Val Arg Leu
 575                 580                 585                 590

 gac ccc gcc cac cag ggc cag atg tgc ggc ctg tgt ggg aac ttc aac     2123
 Asp Pro Ala His Gln Gly Gln Met Cys Gly Leu Cys Gly Asn Phe Asn
                 595                 600                 605

 cag aac cag gct gac gac ttc acg gcc ctc agc ggg gtg gtg gag gcc     2171
 Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu Ser Gly Val Val Glu Ala
             610                 615                 620

 acg ggc gca gcc ttc gcc aac acc tgg aag gcc cag gct gcc tgt gcc     2219
 Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys Ala Gln Ala Ala Cys Ala
         625                 630                 635

 aat gcc agg aac agc ttt gag gac ccc tgc tcc ctc agt gtg gag aat     2267
 Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn
     640                 645                 650

 gag aac tac gcc cgg cac tgg tgc tcg cgc ctg acc gat ccc aac agt     2315
 Glu Asn Tyr Ala Arg His Trp Cys Ser Arg Leu Thr Asp Pro Asn Ser
 655                 660                 665                 670

 gcc ttc tcg cgc tgc cac tcc atc atc aac ccc aag ccc ttc cac tcg     2363
 Ala Phe Ser Arg Cys His Ser Ile Ile Asn Pro Lys Pro Phe His Ser
                 675                 680                 685

 aac tgc atg ttc gac acc tgc aac tgt gag cgg agc gag gac tgc ctg     2411
 Asn Cys Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu
             690                 695                 700

 tgc gcc gcg ctg tcc tcc tat gtg cac gcc tgt gcc gcc aag ggc gta     2459
 Cys Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val
         705                 710                 715

 cag ctc agc gac tgg agg gac ggc gtc tgc acc aag tac atg cag aac     2507
 Gln Leu Ser Asp Trp Arg Asp Gly Val Cys Thr Lys Tyr Met Gln Asn
     720                 725                 730

 tgc ccc aag tcc cag cgc tac gcc tac gtg gtg gat gcc tgc cag ccc     2555
 Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val Val Asp Ala Cys Gln Pro
 735                 740                 745                 750

 act tgc cgc ggc ctg agt gag gcc gac gtc acc tgc agc gtt tcc ttc     2603
 Thr Cys Arg Gly Leu Ser Glu Ala Asp Val Thr Cys Ser Val Ser Phe
                 755                 760                 765

 gtg cct gtg gac ggc tgc acc tgc ccc gcg ggc acc ttc ctc aat gac     2651
 Val Pro Val Asp Gly Cys Thr Cys Pro Ala Gly Thr Phe Leu Asn Asp
             770                 775                 780

 gcg ggc gcc tgt gtg ccc gcc cag aag tgc ccc tgc tac gct cac ggc     2699
 Ala Gly Ala Cys Val Pro Ala Gln Lys Cys Pro Cys Tyr Ala His Gly
         785                 790                 795

 acc gtg ctg gct cct gga gag gtg gtg cac gac gag ggc gcc gtg tgt     2747
 Thr Val Leu Ala Pro Gly Glu Val Val His Asp Glu Gly Ala Val Cys
     800                 805                 810

 tca tgt acg ggt ggg aag cta agc tgc ctg gga gcc tct ctg cag aaa     2795
 Ser Cys Thr Gly Gly Lys Leu Ser Cys Leu Gly Ala Ser Leu Gln Lys
 815                 820                 825                 830

 agc aca ggg tgt gca gcc ccc atg gtg tac ctg gac tgc agc aac agc     2843
 Ser Thr Gly Cys Ala Ala Pro Met Val Tyr Leu Asp Cys Ser Asn Ser
                 835                 840                 845

 tcg gcg ggc acc cct ggg gcc gag tgc ctc cgg agc tgc cac acg ctg     2891
 Ser Ala Gly Thr Pro Gly Ala Glu Cys Leu Arg Ser Cys His Thr Leu
             850                 855                 860

 gac gtg ggc tgt ttc agc aca cac tgc gtg tcc ggc tgt gtc tgt ccc     2939
 Asp Val Gly Cys Phe Ser Thr His Cys Val Ser Gly Cys Val Cys Pro
         865                 870                 875

 ccg ggg ctg gtg tcg gat ggg agt ggg ggc tgc att gcc gag gag gac     2987
 Pro Gly Leu Val Ser Asp Gly Ser Gly Gly Cys Ile Ala Glu Glu Asp
     880                 885                 890

 tgc ccc tgt gtg cac aac gag gcc acc tac aag cct gga gag acc atc     3035
 Cys Pro Cys Val His Asn Glu Ala Thr Tyr Lys Pro Gly Glu Thr Ile
 895                 900                 905                 910

 agg gtc gac tgc aac acc tgc acc tgc agg aac cgg agg tgg gag tgc     3083
 Arg Val Asp Cys Asn Thr Cys Thr Cys Arg Asn Arg Arg Trp Glu Cys
                 915                 920                 925

 agc cac cgg ctc tgc ctg ggc acc tgc gtg gcc tac ggg gat ggc cac     3131
 Ser His Arg Leu Cys Leu Gly Thr Cys Val Ala Tyr Gly Asp Gly His
             930                 935                 940

 ttc atc acc ttt gat ggc gat cgc tac agc ttt gaa ggc agc tgc gag     3179
 Phe Ile Thr Phe Asp Gly Asp Arg Tyr Ser Phe Glu Gly Ser Cys Glu
         945                 950                 955

 tac atc ttg gcc cag gac tac tgt ggg gac aac acc acc cac ggc acc     3227
 Tyr Ile Leu Ala Gln Asp Tyr Cys Gly Asp Asn Thr Thr His Gly Thr
     960                 965                 970

 ttc cgc atc gtc acc gag aac atc ccc tgt ggg acc acc ggc acc acc     3275
 Phe Arg Ile Val Thr Glu Asn Ile Pro Cys Gly Thr Thr Gly Thr Thr
 975                 980                 985                 990

 tgc tcc aag gcc atc aag ctc ttc gtg gag agc tac gag ctg atc ctc     3323
 Cys Ser Lys Ala Ile Lys Leu Phe Val Glu Ser Tyr Glu Leu Ile Leu
                 995                1000                1005

 caa gag ggg acc ttt aag gcg gtg gcg aga ggg ccg ggt ggg gac cca     3371
 Gln Glu Gly Thr Phe Lys Ala Val Ala Arg Gly Pro Gly Gly Asp Pro
            1010                1015                1020

 ccc tac aag ata cgc tac atg ggg atc ttc ctg gtc atc gag acc cac     3419
 Pro Tyr Lys Ile Arg Tyr Met Gly Ile Phe Leu Val Ile Glu Thr His
        1025                1030                1035

 ggg atg gcc gtg tcc tgg gac cgg aag acc agc gtg ttc atc cga ctg     3467
 Gly Met Ala Val Ser Trp Asp Arg Lys Thr Ser Val Phe Ile Arg Leu
    1040                1045                1050

 cac cag gac tac aag ggc agg gtc tgc ggc ctg tgc ggg aac ttc gac     3515
 His Gln Asp Tyr Lys Gly Arg Val Cys Gly Leu Cys Gly Asn Phe Asp
1055                1060                1065                1070

 gac aat gcc atc aat gac ttt gcc acg cgt agc cgg tcc gtg gtg ggg     3563
 Asp Asn Ala Ile Asn Asp Phe Ala Thr Arg Ser Arg Ser Val Val Gly
                1075                1080                1085

 gac gca ctg gag ttt ggg aac agc tgg aag ctc tcc ccc tcc tgc ccg     3611
 Asp Ala Leu Glu Phe Gly Asn Ser Trp Lys Leu Ser Pro Ser Cys Pro
            1090                1095                1100

 gac gcc ctg gca ccc aag gac ccc tgc acg gcc aac ccc ttc cgc aag     3659
 Asp Ala Leu Ala Pro Lys Asp Pro Cys Thr Ala Asn Pro Phe Arg Lys
        1105                1110                1115

 tcc tgg gcc cag aag cag tgc agc atc ctc cac ggc ccc acc ttc gcc     3707
 Ser Trp Ala Gln Lys Gln Cys Ser Ile Leu His Gly Pro Thr Phe Ala
    1120                1125                1130

 gcc tgc cgc tcc cag gtt gac tcc acc aag tac tac gag gcc tgc gtg     3755
 Ala Cys Arg Ser Gln Val Asp Ser Thr Lys Tyr Tyr Glu Ala Cys Val
1135                1140                1145                1150

 aac gac gcg tgt gcc tgc gac tcg ggt ggc gac tgc gag tgt ttc tgc     3803
 Asn Asp Ala Cys Ala Cys Asp Ser Gly Gly Asp Cys Glu Cys Phe Cys
                1155                1160                1165

 acg gct gtg gct gcc tac gcc cag gcc tgc cac gac gcg ggc ctg tgt     3851
 Thr Ala Val Ala Ala Tyr Ala Gln Ala Cys His Asp Ala Gly Leu Cys
            1170                1175                1180

 gtg tcc tgg cgg act ccg gac acc tgc ccc ttg ttc tgt gac ttc tac     3899
 Val Ser Trp Arg Thr Pro Asp Thr Cys Pro Leu Phe Cys Asp Phe Tyr
        1185                1190                1195

 aac cca cat ggg ggc tgt gag tgg cac tac cag ccc tgc ggg gca ccc     3947
 Asn Pro His Gly Gly Cys Glu Trp His Tyr Gln Pro Cys Gly Ala Pro
    1200                1205                1210

 tgc cta aaa acc tgc cgg aac ccc agt ggg cac tgc ctg gtg gac ctg     3995
 Cys Leu Lys Thr Cys Arg Asn Pro Ser Gly His Cys Leu Val Asp Leu
1215                1220                1225                1230

 cct ggc ctg gaa ggc tgc tac ccg aag tgc cca ccc agc cag ccc ttc     4043
 Pro Gly Leu Glu Gly Cys Tyr Pro Lys Cys Pro Pro Ser Gln Pro Phe
                1235                1240                1245

 ttc aat gag gac cag atg aag tgc gtg gcc cag tgt ggc tgc tac gac     4091
 Phe Asn Glu Asp Gln Met Lys Cys Val Ala Gln Cys Gly Cys Tyr Asp
            1250                1255                1260

 aag gac gga aac tac tat gac gtc ggt gca agg gtc ccc aca gcg gag     4139
 Lys Asp Gly Asn Tyr Tyr Asp Val Gly Ala Arg Val Pro Thr Ala Glu
        1265                1270                1275

 aac tgc cag agc tgt aac tgc aca ccc agt ggc atc cag tgc gct cac     4187
 Asn Cys Gln Ser Cys Asn Cys Thr Pro Ser Gly Ile Gln Cys Ala His
    1280                1285                1290

 agc ctt gag gcc tgc acc tgc acc tat gag gac agg acc tac agc tac     4235
 Ser Leu Glu Ala Cys Thr Cys Thr Tyr Glu Asp Arg Thr Tyr Ser Tyr
1295                1300                1305                1310

 cag gac gtc atc tac aac acc acc gat ggg ctt ggc gcc tgc ttg atc     4283
 Gln Asp Val Ile Tyr Asn Thr Thr Asp Gly Leu Gly Ala Cys Leu Ile
                1315                1320                1325

 gcc atc tgc gga agc aac ggc acc atc atc agg aag gct gtg gca tgt     4331
 Ala Ile Cys Gly Ser Asn Gly Thr Ile Ile Arg Lys Ala Val Ala Cys
            1330                1335                1340

 cct gga act cca gcc aca acg cca ttc acc ttc acc acc gcc tgg gtc     4379
 Pro Gly Thr Pro Ala Thr Thr Pro Phe Thr Phe Thr Thr Ala Trp Val
        1345                1350                1355

 ccc cac tcc acg aca agc                                             4397
 Pro His Ser Thr Thr Ser 
    1360





      <210> 37
      <211> 5735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(3903)

      <400> 37
 agttcctcag ca    atg tct aca agt gac atc cca tct tcc cct agc atc      48
                  Met Ser Thr Ser Asp Ile Pro Ser Ser Pro Ser Ile
                    1               5                  10

 cag aat aca gaa acc tca tcc ctt gtc agc atg acc tct gcc acc att       96
 Gln Asn Thr Glu Thr Ser Ser Leu Val Ser Met Thr Ser Ala Thr Ile
          15                  20                  25

 ccc agt gtg aga cca act ttt aca agt aca cac aac act ctg aca agt      144
 Pro Ser Val Arg Pro Thr Phe Thr Ser Thr His Asn Thr Leu Thr Ser
      30                  35                  40

 tcc ctc cta acg acg ttc cca ggg acg tat tca ttt tcc tct tcc atg      192
 Ser Leu Leu Thr Thr Phe Pro Gly Thr Tyr Ser Phe Ser Ser Ser Met
  45                  50                  55                  60

 tct gcc agc agt gat ggg acc act cac aca gaa act atc acc tca ctt      240
 Ser Ala Ser Ser Asp Gly Thr Thr His Thr Glu Thr Ile Thr Ser Leu
                  65                  70                  75

 cca gcc agc acc agt aca ctc cac acc aca gct gaa tcc acc aca gca      288
 Pro Ala Ser Thr Ser Thr Leu His Thr Thr Ala Glu Ser Thr Thr Ala
              80                  85                  90

 cac act acc acc acc tca ttc aca act tcc aca act atg gaa tca cct      336
 His Thr Thr Thr Thr Ser Phe Thr Thr Ser Thr Thr Met Glu Ser Pro
          95                 100                 105

 tca tcc agt gta gca act aca agc aca ggt cag acc acc ttc tcc agc      384
 Ser Ser Ser Val Ala Thr Thr Ser Thr Gly Gln Thr Thr Phe Ser Ser
     110                 115                 120

 tct acg gcc aca ttc act gag acc acc aca ttg act cct acg act gac      432
 Ser Thr Ala Thr Phe Thr Glu Thr Thr Thr Leu Thr Pro Thr Thr Asp
 125                 130                 135                 140

 ttt tct gaa gaa act ctc aca aca gcc atg act tct act ccc ccc atc      480
 Phe Ser Glu Glu Thr Leu Thr Thr Ala Met Thr Ser Thr Pro Pro Ile
                 145                 150                 155

 act tct tca atc act ccc acc aat aca gtg act tct atg aca act atg      528
 Thr Ser Ser Ile Thr Pro Thr Asn Thr Val Thr Ser Met Thr Thr Met
             160                 165                 170

 acc tcc tgg ccc aca gcc act aat acg ttg tca tcc ctc acc act aac      576
 Thr Ser Trp Pro Thr Ala Thr Asn Thr Leu Ser Ser Leu Thr Thr Asn
         175                 180                 185

 att tta tct tct aca cct gtc ccg agc aca gag agg acc acc agt cat      624
 Ile Leu Ser Ser Thr Pro Val Pro Ser Thr Glu Arg Thr Thr Ser His
     190                 195                 200

 act aca aac atc aat cct gta tcc acc ttg gtg acc aca ctc ccc act      672
 Thr Thr Asn Ile Asn Pro Val Ser Thr Leu Val Thr Thr Leu Pro Thr
 205                 210                 215                 220

 acc atc acc agg tct aca cct aca tct gag acc acc tac cct att tct      720
 Thr Ile Thr Arg Ser Thr Pro Thr Ser Glu Thr Thr Tyr Pro Ile Ser
                 225                 230                 235

 tcc acc agc act gtc aca gag tcc acg act gaa atc acc tat tcc act      768
 Ser Thr Ser Thr Val Thr Glu Ser Thr Thr Glu Ile Thr Tyr Ser Thr
             240                 245                 250

 act atg aca gag aca tca tcc agt gcc acc tct ctt cca ctc acc tct      816
 Thr Met Thr Glu Thr Ser Ser Ser Ala Thr Ser Leu Pro Leu Thr Ser
         255                 260                 265

 ccc ttg gtc tca acc aca gaa aca gcc aaa act cct acc aca atc ttg      864
 Pro Leu Val Ser Thr Thr Glu Thr Ala Lys Thr Pro Thr Thr Ile Leu
     270                 275                 280

 gta acc acc acc acc aag acc acc tca cat agt acc acc agc ttc act      912
 Val Thr Thr Thr Thr Lys Thr Thr Ser His Ser Thr Thr Ser Phe Thr
 285                 290                 295                 300

 tct tca acc gtc tac tcc aca gcc agc aca cac acc act gcc atc act      960
 Ser Ser Thr Val Tyr Ser Thr Ala Ser Thr His Thr Thr Ala Ile Thr
                 305                 310                 315

 tca gtt ccc act acc ttg ggt acc atg gtg act tct aca tcc agg atc     1008
 Ser Val Pro Thr Thr Leu Gly Thr Met Val Thr Ser Thr Ser Arg Ile
             320                 325                 330

 cca tct act gtg agt acg agt atc cct acc tca caa cca aaa acc gtc     1056
 Pro Ser Thr Val Ser Thr Ser Ile Pro Thr Ser Gln Pro Lys Thr Val
         335                 340                 345

 aat tcc tca tct ggg ggc atc act ggt tca tta cct atg atg aca gac     1104
 Asn Ser Ser Ser Gly Gly Ile Thr Gly Ser Leu Pro Met Met Thr Asp
     350                 355                 360

 ctt acc tca ggg tac acc gtc tcc agt atg tct gca att ccc aca act     1152
 Leu Thr Ser Gly Tyr Thr Val Ser Ser Met Ser Ala Ile Pro Thr Thr
 365                 370                 375                 380

 gtc att cct aca tct ctc act gtc cag aat aca gaa acc tca atc ttt     1200
 Val Ile Pro Thr Ser Leu Thr Val Gln Asn Thr Glu Thr Ser Ile Phe
                 385                 390                 395

 gtc agc atg acc tct gcc acc act ccc agt ggg aga cca act ttc aca     1248
 Val Ser Met Thr Ser Ala Thr Thr Pro Ser Gly Arg Pro Thr Phe Thr
             400                 405                 410

 agt act gtg aac act ccc aca agg tcc ctc ctg aca agc ttt cca acg     1296
 Ser Thr Val Asn Thr Pro Thr Arg Ser Leu Leu Thr Ser Phe Pro Thr
         415                 420                 425

 aca cat tta ttc tct tct tcc atg tct gaa agc agt gct ggg acc act     1344
 Thr His Leu Phe Ser Ser Ser Met Ser Glu Ser Ser Ala Gly Thr Thr
     430                 435                 440

 cac aca gag agt atc tcc tca cct cca gcc acc acc agt aca ctc cac     1392
 His Thr Glu Ser Ile Ser Ser Pro Pro Ala Thr Thr Ser Thr Leu His
 445                 450                 455                 460

 aca aca gct gaa tcc acc ccg tcg tgc act acc acc acg tca ttc atc     1440
 Thr Thr Ala Glu Ser Thr Pro Ser Cys Thr Thr Thr Thr Ser Phe Ile
                 465                 470                 475

 aca tcc aca act atg gaa cca ctt tca acc att gta gca acg aca ggc     1488
 Thr Ser Thr Thr Met Glu Pro Leu Ser Thr Ile Val Ala Thr Thr Gly
             480                 485                 490

 aca gtt aag acc acc gtc acc agc tcc aca gcc aca ttc cgg gag acc     1536
 Thr Val Lys Thr Thr Val Thr Ser Ser Thr Ala Thr Phe Arg Glu Thr
         495                 500                 505

 acc aca ctg act tct aca act gac atc tcc aca gaa tct ctc atg aca     1584
 Thr Thr Leu Thr Ser Thr Thr Asp Ile Ser Thr Glu Ser Leu Met Thr
     510                 515                 520

 gca atg act tct act acc cga ctc act tct gca atc act tcc aag act     1632
 Ala Met Thr Ser Thr Thr Arg Leu Thr Ser Ala Ile Thr Ser Lys Thr
 525                 530                 535                 540

 aca ttg act tct ttg aag act act gcc tcc cgg ccc aca gcc aat agt     1680
 Thr Leu Thr Ser Leu Lys Thr Thr Ala Ser Arg Pro Thr Ala Asn Ser
                 545                 550                 555

 acg tta tca tca ctc acc agt agc att ttg tct tcc aca ctt gtc ccc     1728
 Thr Leu Ser Ser Leu Thr Ser Ser Ile Leu Ser Ser Thr Leu Val Pro
             560                 565                 570

 agc aca gac atg atc act agt cat acc aca aac ctt acc cgt tca tct     1776
 Ser Thr Asp Met Ile Thr Ser His Thr Thr Asn Leu Thr Arg Ser Ser
         575                 580                 585

 ccc ttg ctt gcc aca ctc cct act acc atc acc agg tct aca cct aca     1824
 Pro Leu Leu Ala Thr Leu Pro Thr Thr Ile Thr Arg Ser Thr Pro Thr
     590                 595                 600

 tct gag acc aca tac cct act tct cct acc agc aca gtg aaa ggc tcc     1872
 Ser Glu Thr Thr Tyr Pro Thr Ser Pro Thr Ser Thr Val Lys Gly Ser
 605                 610                 615                 620

 acg acc agc atc agg tat tcc aca agt atg aca ggt aca ttg tct atg     1920
 Thr Thr Ser Ile Arg Tyr Ser Thr Ser Met Thr Gly Thr Leu Ser Met
                 625                 630                 635

 gag act tct ctc cca ccc acc tct tcc tct ctc cca acc aca gaa aca     1968
 Glu Thr Ser Leu Pro Pro Thr Ser Ser Ser Leu Pro Thr Thr Glu Thr
             640                 645                 650

 gcc acg atg act cct acc aca acc ttg ata acc acc acc cct aat acc     2016
 Ala Thr Met Thr Pro Thr Thr Thr Leu Ile Thr Thr Thr Pro Asn Thr
         655                 660                 665

 acc tcc cat agt acc ccc agc ttc act tct tca acc atc tac tcc aca     2064
 Thr Ser His Ser Thr Pro Ser Phe Thr Ser Ser Thr Ile Tyr Ser Thr
     670                 675                 680

 gtc agc aca tcc aca act gcc atc acc tca cat ttt act acc tca gag     2112
 Val Ser Thr Ser Thr Thr Ala Ile Thr Ser His Phe Thr Thr Ser Glu
 685                 690                 695                 700

 act gcg gtg act ccc aca cct gta acc cca tct tct ctg agt aca gac     2160
 Thr Ala Val Thr Pro Thr Pro Val Thr Pro Ser Ser Leu Ser Thr Asp
                 705                 710                 715

 atc ccg acc aca agc cta cga act ctc acc cct tcg tct gtg ggc acc     2208
 Ile Pro Thr Thr Ser Leu Arg Thr Leu Thr Pro Ser Ser Val Gly Thr
             720                 725                 730

 agc act tca ttg act aca acc aca gac ttt ccc tct ata ccc act gat     2256
 Ser Thr Ser Leu Thr Thr Thr Thr Asp Phe Pro Ser Ile Pro Thr Asp
         735                 740                 745

 atc agt acc tta cca act cga aca cac atc att tca tct tct ccc tcc     2304
 Ile Ser Thr Leu Pro Thr Arg Thr His Ile Ile Ser Ser Ser Pro Ser
     750                 755                 760

 atc caa agt aca gaa acc tca tcc ctt gtg ggc acc acc tct ccc acc     2352
 Ile Gln Ser Thr Glu Thr Ser Ser Leu Val Gly Thr Thr Ser Pro Thr
 765                 770                 775                 780

 atg tcc act gtg aga atg acc ctc aga att act gag aac acc cca atc     2400
 Met Ser Thr Val Arg Met Thr Leu Arg Ile Thr Glu Asn Thr Pro Ile
                 785                 790                 795

 agt tcc ttt agc aca agt att gtt gtt ata cct gaa acc cca aca cag     2448
 Ser Ser Phe Ser Thr Ser Ile Val Val Ile Pro Glu Thr Pro Thr Gln
             800                 805                 810

 acc cct cct gta ctg acg tca gcc act ggg acc caa aca tct cct gca     2496
 Thr Pro Pro Val Leu Thr Ser Ala Thr Gly Thr Gln Thr Ser Pro Ala
         815                 820                 825

 cct act act gtc acc ttt gga agt acg gat tcc tcc acg tcc act ctt     2544
 Pro Thr Thr Val Thr Phe Gly Ser Thr Asp Ser Ser Thr Ser Thr Leu
     830                 835                 840

 cat act ctt act cca tca aca gcc ttg agc acg atc gtg tca aca tca     2592
 His Thr Leu Thr Pro Ser Thr Ala Leu Ser Thr Ile Val Ser Thr Ser
 845                 850                 855                 860

 cag gtt cct att cct agc aca cat tcc tcc acc ctt caa aca act cct     2640
 Gln Val Pro Ile Pro Ser Thr His Ser Ser Thr Leu Gln Thr Thr Pro
                 865                 870                 875

 tct act ccc tca ttg caa act tca ctc aca tct aca agt gag ttc act     2688
 Ser Thr Pro Ser Leu Gln Thr Ser Leu Thr Ser Thr Ser Glu Phe Thr
             880                 885                 890

 aca gaa tct ttc act agg gga agt acg tct aca aat gca atc ttg act     2736
 Thr Glu Ser Phe Thr Arg Gly Ser Thr Ser Thr Asn Ala Ile Leu Thr
         895                 900                 905

 tct ttt agt acc atc atc tgg tcc tca aca ccc act att atc atg tcc     2784
 Ser Phe Ser Thr Ile Ile Trp Ser Ser Thr Pro Thr Ile Ile Met Ser
     910                 915                 920

 tct tct cca tct tct gcc agc ata act cca gtg ttc tcc act acc att     2832
 Ser Ser Pro Ser Ser Ala Ser Ile Thr Pro Val Phe Ser Thr Thr Ile
 925                 930                 935                 940

 cat tct gtt cct tct tca cca tac att ttc agt aca gaa aat gtg ggc     2880
 His Ser Val Pro Ser Ser Pro Tyr Ile Phe Ser Thr Glu Asn Val Gly
                 945                 950                 955

 tcc gct tct atc aca ggc ttt cct agt ctc tct tcc tct gca act acc     2928
 Ser Ala Ser Ile Thr Gly Phe Pro Ser Leu Ser Ser Ser Ala Thr Thr
             960                 965                 970

 agc act tct tca acc agc tcc tct ctg acc aca gct ctc act gaa ata     2976
 Ser Thr Ser Ser Thr Ser Ser Ser Leu Thr Thr Ala Leu Thr Glu Ile
         975                 980                 985

 acc ccc ttt tct tat att tcc ctt ccc tcc acc aca ccc tgt cca gga     3024
 Thr Pro Phe Ser Tyr Ile Ser Leu Pro Ser Thr Thr Pro Cys Pro Gly
     990                 995                1000

 act ata aca att acc ata gtc cct gcc tct ccc act gat cca tgt gtt     3072
 Thr Ile Thr Ile Thr Ile Val Pro Ala Ser Pro Thr Asp Pro Cys Val
1005                1010                1015                1020

 gaa atg gat ccc agc act gaa gct act tct cct ccc acc acc cca tta     3120
 Glu Met Asp Pro Ser Thr Glu Ala Thr Ser Pro Pro Thr Thr Pro Leu
                1025                1030                1035

 aca gtc ttt ccc ttt act acc gaa atg gtc acc tgt cct acc tcc atc     3168
 Thr Val Phe Pro Phe Thr Thr Glu Met Val Thr Cys Pro Thr Ser Ile
            1040                1045                1050

 agt atc caa act act ctt act aca tat atg gac act tct tcc atg atg     3216
 Ser Ile Gln Thr Thr Leu Thr Thr Tyr Met Asp Thr Ser Ser Met Met
        1055                1060                1065

 cca gaa agt gag tcc agc atc tca ccc aat gct tcc agt tcc act ggc     3264
 Pro Glu Ser Glu Ser Ser Ile Ser Pro Asn Ala Ser Ser Ser Thr Gly
    1070                1075                1080

 act ggg act gta ccc aca aac aca gtt ttc aca agt act cga ctg ccc     3312
 Thr Gly Thr Val Pro Thr Asn Thr Val Phe Thr Ser Thr Arg Leu Pro
1085                1090                1095                1100

 acc agt gag acc tgg ctg agc aac agt tct gtg atc ccc cta cct ctt     3360
 Thr Ser Glu Thr Trp Leu Ser Asn Ser Ser Val Ile Pro Leu Pro Leu
                1105                1110                1115

 cct ggc gtc tct acc atc ccg ctc acc atg aaa cca agc agt agc ctc     3408
 Pro Gly Val Ser Thr Ile Pro Leu Thr Met Lys Pro Ser Ser Ser Leu
            1120                1125                1130

 ccg acc atc ctg agg act tca agc aag tca aca cac cca tcc cca ccc     3456
 Pro Thr Ile Leu Arg Thr Ser Ser Lys Ser Thr His Pro Ser Pro Pro
        1135                1140                1145

 acc act agg act tca gag aca cca gtg gcc act acc cag act cct acc     3504
 Thr Thr Arg Thr Ser Glu Thr Pro Val Ala Thr Thr Gln Thr Pro Thr
    1150                1155                1160

 acc ctt aca tca cgc agg aca act cgc atc act tct cag atg acc aca     3552
 Thr Leu Thr Ser Arg Arg Thr Thr Arg Ile Thr Ser Gln Met Thr Thr
1165                1170                1175                1180

 cag tcc acg ttg acc acc act gca ggc acc tgt gac aat ggt ggc acc     3600
 Gln Ser Thr Leu Thr Thr Thr Ala Gly Thr Cys Asp Asn Gly Gly Thr
                1185                1190                1195

 tgg gaa cag ggc cag tgt gct tgc ctt ccg ggg ttt tct ggg gac cgc     3648
 Trp Glu Gln Gly Gln Cys Ala Cys Leu Pro Gly Phe Ser Gly Asp Arg
            1200                1205                1210

 tgt cag ctc cag acc aga tgc cag aat ggg ggt cag tgg gat ggc ctc     3696
 Cys Gln Leu Gln Thr Arg Cys Gln Asn Gly Gly Gln Trp Asp Gly Leu
        1215                1220                1225

 aaa tgc cag tgc ccc agc acc ttc tat ggt tcc agt tgt gag ttt gct     3744
 Lys Cys Gln Cys Pro Ser Thr Phe Tyr Gly Ser Ser Cys Glu Phe Ala
    1230                1235                1240

 gtg gaa cag gtg gat cta gat gca gaa gat ttt tgc aga cat gca ggg     3792
 Val Glu Gln Val Asp Leu Asp Ala Glu Asp Phe Cys Arg His Ala Gly
1245                1250                1255                1260

 ctt cac ctt caa ggg tgt gga gat cct gtc cct gag gaa tgg cag cat     3840
 Leu His Leu Gln Gly Cys Gly Asp Pro Val Pro Glu Glu Trp Gln His
                1265                1270                1275

 cgt ggt gga cta cct ggt cct gct gga gat gcc ctt cag ccc cca gct     3888
 Arg Gly Gly Leu Pro Gly Pro Ala Gly Asp Ala Leu Gln Pro Pro Ala
            1280                1285                1290

 gga gag cga gta tga gcaggtgaag accacgctga aggaggggct gcagaacgcc     3943
 Gly Glu Arg Val 
        1295

 agccaggatg tgaacagctg ccaggactcc cagaccctgt gttttaagcc tgactccatc   4003

 aaggtgaaca acaacagcaa gacagagctg accccggcag ccatctgccg cgcgccgctc   4063

 ccacgggcta tgaagagttc tacttcccct tggtggaggc cacccggctc cgctgtgtca   4123

 ccaaatgcac gtctggggtg gacaacgcca tcgactgtca ccagggccag tgcgttctgg   4183

 agacgagcgg tcccacgtgt cgctgctact ccaccgacac gcactggttc tctggcccgc   4243

 gctgcgaggt ggccgtccac tggagggcgc tggtcggggc ctgacggccg gcgcgcgctg   4303

 ctggtgctgc tgctcgtggc gctgggcgtc cgggcggtgc gctccggatg gtggggcggc   4363

 cagcgccgag gccggtcctg ggaccaggac aggaaatggt tcgagacctg ggatgaggaa   4423

 gtcgtgggca ctttttcaaa ctggggtttc gaggacgacg gaacagacaa ggatacaaat   4483

 ttctatgtgg ccttggagaa cgtgacacca ctatgaaggt gcacatcaag agacccgaga   4543

 tgacctcgtc ctcagtgtga gcctgcgggg ccccttcacc accccctccg ccctgccccg   4603

 gacacaaggg tctgcattgc gtccatttca agaggtgacc ccaggacgcg ggcagcccag   4663

 gctcctgctg ttcttgggca agatgagact gttcccccaa atcccatcct tctccttcca   4723

 acttggctga aacccacctg gagacgcagt tcacgtccag gctcttccac tgtggaatct   4783

 tgggcaagtc agtaacgagc ctcagtttcc tcacctgcaa aacgggtaca gcattcctgt   4843

 atgatacgtc acgccgttgt tgtgaaaacc acatagactt ggtcaattct cggtcctact   4903

 ctgccctccc gtctcagccc tcgtgttgcc attgcctctc tcggatcctc caatcctcac   4963

 gtccttcacc tggtctctgg ccctggttct tattttctct caattcccta ctgcctgttt   5023

 cttactttga acctggaggc agcctgcagc cccatcccat ctcctgccct ctcctgatct   5083

 aactccctgc tgcatctctt gctcccattc cttagacgtc ctcccctttt gaccccgttc   5143

 cttcatccat cctgcacccc agtcccccag ccctaaatcc tccctcctct cctcacatcc   5203

 tggcccctag caaggtatag atagcctctg tgtcttagga taccccgggt gctgttccct   5263

 cggtcatcct gttgcccagt tccccgtttc tcttgctctc attcctgtat cctttcccct   5323

 tttgagcccg tccattcatc ggttctgccc ccgactcccc cagccctaaa taccccagct   5383

 gctgttcccc ccatcaccct gctgcccaat tctttattct ccaccccttt ctctcacccc   5443

 tggagccctg cgggtggggg cagggcatga gttccccagt ccccaaggaa aggcagcccc   5503

 ctcagtctcc ctcctcctca ttcccttcca tctccctccc ctctgccttt taaacccatc   5563

 ccctccgatt cccctcctcc cccctctctc cctggtgtca cctggattcc tgcagtaatt   5623

 ctgagccctt gaaatcctca gtcgccttgg cggggaagat tggctttggg gacaggaggt   5683

 cggcacatct ccaggtcttc atgtgcgcaa tatagagttt attgtaaaaa gc           5735




      <210> 38
      <211> 1531
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(1270)

      <400> 38
 cacacatggt ctctgtgtgt tctaatccct gttcattctc atttactgtc taaagttgag     60

 gagatgggat gtcccagatg atagggctcc tgggatttca gacccaagac cagcaggact    120

 ccagtcacct ctaccccagc tctccaggac acagcgctcc caactctgag tgacgtccca    180

 cctctggtcc ttgcagcaca accaacgtgg gaatcacacc ctccagacct cccacagctc    240

 caccccagac tgggcgccgg ccctgcctcc atttcagctg tgacaacctc agagccgtgt    300

 tggcccaagc   atg aca agg acg tat gaa aac ttc cag tac ttg gag aat     349
              Met Thr Arg Thr Tyr Glu Asn Phe Gln Tyr Leu Glu Asn
                1               5                  10

 aag gtg aaa gtc cag ggg ttt aaa aat ggg cca ctt cct ctc cag tcc      397
 Lys Val Lys Val Gln Gly Phe Lys Asn Gly Pro Leu Pro Leu Gln Ser
      15                  20                  25

 ctc ctg cag cgt ctc tgc tct ggg ccc tgc cat ctc ctg ctg tcc ctg      445
 Leu Leu Gln Arg Leu Cys Ser Gly Pro Cys His Leu Leu Leu Ser Leu
  30                  35                  40                  45

 ggc ctc ggc ctc ctg ctg ctg gtc atc atc tgt gtg gtt gga ttc caa      493
 Gly Leu Gly Leu Leu Leu Leu Val Ile Ile Cys Val Val Gly Phe Gln
                  50                  55                  60

 aat tcc aaa ttt cag agg gac ctg gtg acc ctg aga aca gat ttt agc      541
 Asn Ser Lys Phe Gln Arg Asp Leu Val Thr Leu Arg Thr Asp Phe Ser
              65                  70                  75

 aac ttc acc tca aac act gtg gcg gag atc cag gca ctg act tcc cag      589
 Asn Phe Thr Ser Asn Thr Val Ala Glu Ile Gln Ala Leu Thr Ser Gln
          80                  85                  90

 ggc agc agc ttg gaa gaa acg ata gca tct ctg aaa gct gag gtg gag      637
 Gly Ser Ser Leu Glu Glu Thr Ile Ala Ser Leu Lys Ala Glu Val Glu
      95                 100                 105

 ggt ttc aag cag gaa cgg cag gca ggg gta tct gag ctc cag gaa cac      685
 Gly Phe Lys Gln Glu Arg Gln Ala Gly Val Ser Glu Leu Gln Glu His
 110                 115                 120                 125

 act acg cag aag gca cac cta ggc cac tgt ccc cac tgc cca tct gtg      733
 Thr Thr Gln Lys Ala His Leu Gly His Cys Pro His Cys Pro Ser Val
                 130                 135                 140

 tgt gtc cca gtt cat tct gaa atg ctc ctg cga gtc cag cag ctg gtg      781
 Cys Val Pro Val His Ser Glu Met Leu Leu Arg Val Gln Gln Leu Val
             145                 150                 155

 caa gac ctg aag aaa ctg acc tgc cag gtg gct act ctc aac aac aat      829
 Gln Asp Leu Lys Lys Leu Thr Cys Gln Val Ala Thr Leu Asn Asn Asn
         160                 165                 170

 ggt gag gaa gcc tcc act gaa ggg acc tgc tgc cct gtc aac tgg gtg      877
 Gly Glu Glu Ala Ser Thr Glu Gly Thr Cys Cys Pro Val Asn Trp Val
     175                 180                 185

 gag cac caa gac agc tgc tac tgg ttc tct cac tct ggg atg tcc tgg      925
 Glu His Gln Asp Ser Cys Tyr Trp Phe Ser His Ser Gly Met Ser Trp
 190                 195                 200                 205

 gcc gag gct gag aag tac tgc cag ctg aag aac gcc cac ctg gtg gtc      973
 Ala Glu Ala Glu Lys Tyr Cys Gln Leu Lys Asn Ala His Leu Val Val
                 210                 215                 220

 atc aac tcc agg gag gag cag aat ttt gtc cag aaa tat cta ggc tcc     1021
 Ile Asn Ser Arg Glu Glu Gln Asn Phe Val Gln Lys Tyr Leu Gly Ser
             225                 230                 235

 gca tac acc tgg atg ggc ctc agt gac cct gaa gga gcc tgg aag tgg     1069
 Ala Tyr Thr Trp Met Gly Leu Ser Asp Pro Glu Gly Ala Trp Lys Trp
         240                 245                 250

 gtg gat gga aca gac tat gcg acc ggc ttc cag aac tgg aag cca ggc     1117
 Val Asp Gly Thr Asp Tyr Ala Thr Gly Phe Gln Asn Trp Lys Pro Gly
     255                 260                 265

 cag cca gac gac tgg cag ggg cac ggg ctg ggt gga ggc gag gac tgt     1165
 Gln Pro Asp Asp Trp Gln Gly His Gly Leu Gly Gly Gly Glu Asp Cys
 270                 275                 280                 285

 gct cac ttc cat cca gac ggc agg tgg aat gac gac gtc tgc cag agg     1213
 Ala His Phe His Pro Asp Gly Arg Trp Asn Asp Asp Val Cys Gln Arg
                 290                 295                 300

 ccc tac cac tgg gtc tgc gag gct ggc ctg ggt cag acc agc cag gag     1261
 Pro Tyr His Trp Val Cys Glu Ala Gly Leu Gly Gln Thr Ser Gln Glu
             305                 310                 315

 agt cac tga gctgcct ttggtgggac cacccggcca cagaaatggc ggtgggagga     1317
 Ser His 


 ggactcttct cacgacctcc tcgcaagacc gctctgggag agaaataagc actgggagat   1377

 tggaagcact gctaacattt tgaatttttt tctctttaat tttaaaaaga tggtatagtg   1437

 ttcttaagct tttatttttt ttccaacttt tgaaagtcaa cttcatgaag gtataatttt   1497

 tacataataa aaatgcactc atttaaagag taaa                               1531




      <210> 39
      <211> 2444
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(1956)

      <400> 39
 gtacacattc caaaaagaga ttgatacact tgcaatgaag ggttcttgct tgagggagcc     60

 aggagtcggg tttgtcttgc caatggaagt tggagtggag ccactcccga ctgtgtgcct    120

 gtcagatgtg ccaccccgcc acaactggcc aatggggtga cggaaggcct ggactatggc    180

 ttc  atg aag gaa gta aca ttc cac tgt cat gag ggc tac atc ttg cac     228
      Met Lys Glu Val Thr Phe His Cys His Glu Gly Tyr Ile Leu His
        1               5                  10                  15

 ggt gct cca aaa ctc acc tgt cag tca gat ggc aac tgg gat gca gag      276
 Gly Ala Pro Lys Leu Thr Cys Gln Ser Asp Gly Asn Trp Asp Ala Glu
                  20                  25                  30

 att cct ctc tgt aaa cca gtc aac tgt gga cct cct gaa gat ctt gcc      324
 Ile Pro Leu Cys Lys Pro Val Asn Cys Gly Pro Pro Glu Asp Leu Ala
              35                  40                  45

 cat ggt ttc cct aat ggt ttt tcc ttt att cat ggg ggc cat ata cag      372
 His Gly Phe Pro Asn Gly Phe Ser Phe Ile His Gly Gly His Ile Gln
          50                  55                  60

 tat cag tgc ttt cct ggt tat aag ctc cat gga aat tca tca aga agg      420
 Tyr Gln Cys Phe Pro Gly Tyr Lys Leu His Gly Asn Ser Ser Arg Arg
      65                  70                  75

 tgc ctc tcc aat ggc tcc tgg agt ggc agc tca cct tcc tgc ctg cct      468
 Cys Leu Ser Asn Gly Ser Trp Ser Gly Ser Ser Pro Ser Cys Leu Pro
  80                  85                  90                  95

 tgc aga tgt tcc aca cca gta att gaa tat gga act gtc aat ggg aca      516
 Cys Arg Cys Ser Thr Pro Val Ile Glu Tyr Gly Thr Val Asn Gly Thr
                 100                 105                 110

 gat ttt gac tgt gga aag gca gcc cgg att cag tgc ttc aaa ggc ttc      564
 Asp Phe Asp Cys Gly Lys Ala Ala Arg Ile Gln Cys Phe Lys Gly Phe
             115                 120                 125

 aag ctc cta gga ctt tct gaa atc acc tgt gaa gcc gat ggc cag tgg      612
 Lys Leu Leu Gly Leu Ser Glu Ile Thr Cys Glu Ala Asp Gly Gln Trp
         130                 135                 140

 agc tct ggg ttc cac cac ttt gaa cac act tct tgt ggt tct ctt cca      660
 Ser Ser Gly Phe His His Phe Glu His Thr Ser Cys Gly Ser Leu Pro
     145                 150                 155

 atg ata cca aat gcg ttc atc agt gag acc agc tct tgg aag gaa aat      708
 Met Ile Pro Asn Ala Phe Ile Ser Glu Thr Ser Ser Trp Lys Glu Asn
 160                 165                 170                 175

 gtg ata act tac agc tgc agg tct gga tat gtc ata caa ggc agt tca      756
 Val Ile Thr Tyr Ser Cys Arg Ser Gly Tyr Val Ile Gln Gly Ser Ser
                 180                 185                 190

 gat ctg att tgt aca gag aaa ggg gta tgg agc cag cct tat cca gtc      804
 Asp Leu Ile Cys Thr Glu Lys Gly Val Trp Ser Gln Pro Tyr Pro Val
             195                 200                 205

 tgt gag ccc ttg tcc tgt ggg tcc cca ccg tct gtc gcc aat gca gtg      852
 Cys Glu Pro Leu Ser Cys Gly Ser Pro Pro Ser Val Ala Asn Ala Val
         210                 215                 220

 gca act gga gag gca cac acc tat gaa agt gaa gtg aaa ctc aga tgt      900
 Ala Thr Gly Glu Ala His Thr Tyr Glu Ser Glu Val Lys Leu Arg Cys
     225                 230                 235

 ctg gaa ggt tat acg atg gat aca gat acc aga tca atc acc tgt cag      948
 Leu Glu Gly Tyr Thr Met Asp Thr Asp Thr Arg Ser Ile Thr Cys Gln
 240                 245                 250                 255

 aaa gat ggt cgc tgg ttc cct gag aga atc tcc tgc agt cct aaa aaa      996
 Lys Asp Gly Arg Trp Phe Pro Glu Arg Ile Ser Cys Ser Pro Lys Lys
                 260                 265                 270

 tgt cct ctc ccg gaa aac ata aca cat ata ctt gtt cat ggg gac gat     1044
 Cys Pro Leu Pro Glu Asn Ile Thr His Ile Leu Val His Gly Asp Asp
             275                 280                 285

 ttc agt gtg aat agg caa gtt tct gtg tca tgt gca gaa ggg tat acc     1092
 Phe Ser Val Asn Arg Gln Val Ser Val Ser Cys Ala Glu Gly Tyr Thr
         290                 295                 300

 ttt gag gga gtt aac ata tca gta tgt cag ctt gat gga acc tgg gag     1140
 Phe Glu Gly Val Asn Ile Ser Val Cys Gln Leu Asp Gly Thr Trp Glu
     305                 310                 315

 cca cca ttc tcc gat gaa tct tgc agt cca gtt tct tgt ggg aaa cct     1188
 Pro Pro Phe Ser Asp Glu Ser Cys Ser Pro Val Ser Cys Gly Lys Pro
 320                 325                 330                 335

 gaa agt cca gaa cat gga ttt gtg gtt ggc agt aaa tac acc ttt gaa     1236
 Glu Ser Pro Glu His Gly Phe Val Val Gly Ser Lys Tyr Thr Phe Glu
                 340                 345                 350

 agc aca att att tat cag tgt gag cct ggc tat gaa cta gag ggg aac     1284
 Ser Thr Ile Ile Tyr Gln Cys Glu Pro Gly Tyr Glu Leu Glu Gly Asn
             355                 360                 365

 agg gaa cgt gtc tgc cag gag aac aga cag tgg agt gga ggg gtg gca     1332
 Arg Glu Arg Val Cys Gln Glu Asn Arg Gln Trp Ser Gly Gly Val Ala
         370                 375                 380

 ata tgc aaa gag acc agg tgt gaa act cca ctt gaa ttt ctc aat ggg     1380
 Ile Cys Lys Glu Thr Arg Cys Glu Thr Pro Leu Glu Phe Leu Asn Gly
     385                 390                 395

 aaa gct gac att gaa aac agg acg act gga ccc aac gtg gta tat tcc     1428
 Lys Ala Asp Ile Glu Asn Arg Thr Thr Gly Pro Asn Val Val Tyr Ser
 400                 405                 410                 415

 tgc aac aga ggc tac agt ctt gaa ggg cca tct gag gca cac tgc aca     1476
 Cys Asn Arg Gly Tyr Ser Leu Glu Gly Pro Ser Glu Ala His Cys Thr
                 420                 425                 430

 gaa aat gga acc tgg agc cac cca gtc cct ctc tgc aaa cca aat cca     1524
 Glu Asn Gly Thr Trp Ser His Pro Val Pro Leu Cys Lys Pro Asn Pro
             435                 440                 445

 tgc cct gtt cct ttt gtg att ccc gag aat gct ctg ctg tct gaa aag     1572
 Cys Pro Val Pro Phe Val Ile Pro Glu Asn Ala Leu Leu Ser Glu Lys
         450                 455                 460

 gag ttt tat gtt gat cag aat gtg tcc atc aaa tgt agg gaa ggt ttt     1620
 Glu Phe Tyr Val Asp Gln Asn Val Ser Ile Lys Cys Arg Glu Gly Phe
     465                 470                 475

 ctg ctg cag ggc cac ggc atc att acc tgc aac ccc gac gag acg tgg     1668
 Leu Leu Gln Gly His Gly Ile Ile Thr Cys Asn Pro Asp Glu Thr Trp
 480                 485                 490                 495

 aca cag aca agc gcc aaa tgt gaa aaa atc tca tgt ggt cca cca gct     1716
 Thr Gln Thr Ser Ala Lys Cys Glu Lys Ile Ser Cys Gly Pro Pro Ala
                 500                 505                 510

 cac gta gaa aat gca att gct cga ggc gta cat tat caa tat gga gac     1764
 His Val Glu Asn Ala Ile Ala Arg Gly Val His Tyr Gln Tyr Gly Asp
             515                 520                 525

 atg atc acc tac tca tgt tac agt gga tac atg ttg gag ggt ttc ctg     1812
 Met Ile Thr Tyr Ser Cys Tyr Ser Gly Tyr Met Leu Glu Gly Phe Leu
         530                 535                 540

 agg agt gtt tgt tta gaa aat gga aca tgg aca tca cct cct att tgc     1860
 Arg Ser Val Cys Leu Glu Asn Gly Thr Trp Thr Ser Pro Pro Ile Cys
     545                 550                 555

 aga gct gtc tgt cga ttt cca tgt cag aat ggg ggc atc tgc caa cgc     1908
 Arg Ala Val Cys Arg Phe Pro Cys Gln Asn Gly Gly Ile Cys Gln Arg
 560                 565                 570                 575

 cca aat gct tgt tcc tgt cca gag ggc tgg gat ggg gcg cct ctg tga     1956
 Pro Asn Ala Cys Ser Cys Pro Glu Gly Trp Asp Gly Ala Pro Leu 
                 580                 585                 590

 agaattaatc tgcattcttc cctgtctgaa cggaggtcgc tgtgtggccc cttaccagtg   2016

 tgactgcccg cctggctgga cggggtctcg ctgtcataca gctgtttgcc agtctccctg   2076

 cttaaatggt ggaaaatgtg taagaccaaa ccgatgtcac tgtctttctt cttggacggg   2136

 acataactgt tccaggaaaa ggaggactgg gttttaacca ctgcacgacc atctggctct   2196

 cccaaaagca ggatcatctc tcctcggtag tgcctgggca tcctggaact tatgcaaaga   2256

 aagtccaaca tggtgctggg tcttgtttag taaacttgtt acttggggtt acttttttta   2316

 ttttgtgata tattttgtta ttccttgtga catactttct tacatgtttc catttttaaa   2376

 tatgcctgta ttttctatat aaaaattata ttaaatagat gctgctacaa aatgtaaaaa   2436

 aaaaaaaa                                                            2444




      <210> 40
      <211> 9783
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (278)..(4912)

      <400> 40
 ggacgatttc gtggaggatt tctctctagc tcgactcact ctggactgac tcgctccctg     60

 gctttctcag ttcgttttgg gagataactt gttttgctcc aagccgcatc cgttgacccc    120

 ttacagtcgg atggtctaga tgactgaatg gagttttgag ttggactttt gtgtccctga    180

 cggagttggg cctgatccca gagcactggg ggtggggagg aggtgttact gtaaaatgca    240

 agttggataa aaggaggacc tctcgccaag ggcccca atg agt ggc aca cag tct     295
                                          Met Ser Gly Thr Gln Ser
                                            1               5

 act atc acc gac agg ttt ccc ctc aaa aaa cct ata agg cat gga agt      343
 Thr Ile Thr Asp Arg Phe Pro Leu Lys Lys Pro Ile Arg His Gly Ser
              10                  15                  20

 att ttg aac cga gag tca cca aca gat aag aag cag aaa gtt gag cgc      391
 Ile Leu Asn Arg Glu Ser Pro Thr Asp Lys Lys Gln Lys Val Glu Arg
          25                  30                  35

 att gca tca cat gat ttt gac ccc aca gat agc tcc tcc aag aag aca      439
 Ile Ala Ser His Asp Phe Asp Pro Thr Asp Ser Ser Ser Lys Lys Thr
      40                  45                  50

 aag tct agt tca gag gag agt aga tcc gag ata tat ggt ctt gtt cag      487
 Lys Ser Ser Ser Glu Glu Ser Arg Ser Glu Ile Tyr Gly Leu Val Gln
  55                  60                  65                  70

 cgt tgc gta atc atc cag aaa gat gac aat gga ttt ggg ctg acg gtc      535
 Arg Cys Val Ile Ile Gln Lys Asp Asp Asn Gly Phe Gly Leu Thr Val
                  75                  80                  85

 agt gga gac aat cca gtc ttc gta cag tct gtc aaa gaa gat gga gca      583
 Ser Gly Asp Asn Pro Val Phe Val Gln Ser Val Lys Glu Asp Gly Ala
              90                  95                 100

 gcc atg cgg gct gga gta cag aca ggt gat cga atc atc aag gtg aat      631
 Ala Met Arg Ala Gly Val Gln Thr Gly Asp Arg Ile Ile Lys Val Asn
         105                 110                 115

 gga act ctg gtg act cat tca aat cat ctg gag gtg gtg aag cta atc      679
 Gly Thr Leu Val Thr His Ser Asn His Leu Glu Val Val Lys Leu Ile
     120                 125                 130

 aaa tct ggt tcc tat gta gct ctc act gtt cag gga cgc cca cct ggg      727
 Lys Ser Gly Ser Tyr Val Ala Leu Thr Val Gln Gly Arg Pro Pro Gly
 135                 140                 145                 150

 tcg ccc cag att cca ctt gcc gac tct gaa gta gag ccg tca gtc att      775
 Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu Val Glu Pro Ser Val Ile
                 155                 160                 165

 gga cat atg tct ccc atc atg aca tct cct cat tca cct gga gca tct      823
 Gly His Met Ser Pro Ile Met Thr Ser Pro His Ser Pro Gly Ala Ser
             170                 175                 180

 ggg aat atg gag aga atc act agt cct gtg ctc atg ggg gag gaa aac      871
 Gly Asn Met Glu Arg Ile Thr Ser Pro Val Leu Met Gly Glu Glu Asn
         185                 190                 195

 aat gtg gtt cat aac cag aaa gta gaa att ctg aga aaa atg tta cag      919
 Asn Val Val His Asn Gln Lys Val Glu Ile Leu Arg Lys Met Leu Gln
     200                 205                 210

 aaa gaa cag gaa cgg cta cag tta ttg cag gaa gat tac aac cga aca      967
 Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln Glu Asp Tyr Asn Arg Thr
 215                 220                 225                 230

 cct gcc caa aga ttg cta aaa gag atc caa gag gcc aag aaa cac att     1015
 Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln Glu Ala Lys Lys His Ile
                 235                 240                 245

 cct cag ctg caa gag cag tta tcc aaa gcc aca ggc tct gct cag gat     1063
 Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala Thr Gly Ser Ala Gln Asp
             250                 255                 260

 gga gct gta gtt aca ccc tcc aga cct tta ggg gac acc cta aca gtc     1111
 Gly Ala Val Val Thr Pro Ser Arg Pro Leu Gly Asp Thr Leu Thr Val
         265                 270                 275

 agt gag gca gaa aca gat cct gga gat gta ctg ggc agg act gac tgt     1159
 Ser Glu Ala Glu Thr Asp Pro Gly Asp Val Leu Gly Arg Thr Asp Cys
     280                 285                 290

 agc agt gga gat gct tct cgg ccc agt agt gac aat gca gat agt ccc     1207
 Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser Asp Asn Ala Asp Ser Pro
 295                 300                 305                 310

 aag agt ggc cca aaa gag aga att tat cta gag gaa aac cca gag aaa     1255
 Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu Glu Glu Asn Pro Glu Lys
                 315                 320                 325

 agt gaa aca att cag gac act gac act caa tca ctt gtc gga agt ccc     1303
 Ser Glu Thr Ile Gln Asp Thr Asp Thr Gln Ser Leu Val Gly Ser Pro
             330                 335                 340

 tca acc cgt ata gca cct cat att att gga gca gaa gat gat gat ttt     1351
 Ser Thr Arg Ile Ala Pro His Ile Ile Gly Ala Glu Asp Asp Asp Phe
         345                 350                 355

 ggt act gaa cat gaa cag atc aat gga cag tgc agc tgt ttc cag agc     1399
 Gly Thr Glu His Glu Gln Ile Asn Gly Gln Cys Ser Cys Phe Gln Ser
     360                 365                 370

 att gaa tta cta aaa tct cgc ccg gct cat ttg gct gtt ttc tta cac     1447
 Ile Glu Leu Leu Lys Ser Arg Pro Ala His Leu Ala Val Phe Leu His
 375                 380                 385                 390

 cat gta gtt tca caa ttt gac cct gcg act ttg ctt tgt tat ctc tat     1495
 His Val Val Ser Gln Phe Asp Pro Ala Thr Leu Leu Cys Tyr Leu Tyr
                 395                 400                 405

 tca gac ctg tat aaa cat acc aat tcc aaa gaa act cgt cgc atc ttc     1543
 Ser Asp Leu Tyr Lys His Thr Asn Ser Lys Glu Thr Arg Arg Ile Phe
             410                 415                 420

 ctt gag ttt cat cag ttc ttt cta gat cga tca gca cac ctg aaa gtt     1591
 Leu Glu Phe His Gln Phe Phe Leu Asp Arg Ser Ala His Leu Lys Val
         425                 430                 435

 tct gtt cct gat gaa atg tct gca gat cta gaa aag aga aga cct gag     1639
 Ser Val Pro Asp Glu Met Ser Ala Asp Leu Glu Lys Arg Arg Pro Glu
     440                 445                 450

 ctc att cct gag gat ctg cat cgc cac tat atc caa act atg caa gaa     1687
 Leu Ile Pro Glu Asp Leu His Arg His Tyr Ile Gln Thr Met Gln Glu
 455                 460                 465                 470

 aga gtc cat cca gaa gtt caa agg cac tta aaa gat ttt cgg cag aaa     1735
 Arg Val His Pro Glu Val Gln Arg His Leu Lys Asp Phe Arg Gln Lys
                 475                 480                 485

 cgt agt atg gga ctg acc ttg gct gaa agc gag ctg act aaa ctt gat     1783
 Arg Ser Met Gly Leu Thr Leu Ala Glu Ser Glu Leu Thr Lys Leu Asp
             490                 495                 500

 gca gag cga gac aag gac cga ttg act ttg gag aag gag cgg aca tgt     1831
 Ala Glu Arg Asp Lys Asp Arg Leu Thr Leu Glu Lys Glu Arg Thr Cys
         505                 510                 515

 gca gaa cag att gtt gcc aaa att gaa gaa gta ttg atg act gct cag     1879
 Ala Glu Gln Ile Val Ala Lys Ile Glu Glu Val Leu Met Thr Ala Gln
     520                 525                 530

 gct gta gag gaa gat aag agc tcc acc atg cag tat gtt att ctc atg     1927
 Ala Val Glu Glu Asp Lys Ser Ser Thr Met Gln Tyr Val Ile Leu Met
 535                 540                 545                 550

 tat atg aag cat ttg gga gta aaa gtg aaa gag cct cga aat ttg gag     1975
 Tyr Met Lys His Leu Gly Val Lys Val Lys Glu Pro Arg Asn Leu Glu
                 555                 560                 565

 cac aaa cgg ggt cgg att gga ttt ctt ccc aaa atc aag caa agt atg     2023
 His Lys Arg Gly Arg Ile Gly Phe Leu Pro Lys Ile Lys Gln Ser Met
             570                 575                 580

 aag aaa gat aaa gaa ggg gaa gaa aaa ggg aag cga aga gga ttc ccc     2071
 Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly Lys Arg Arg Gly Phe Pro
         585                 590                 595

 agc atc ctg gga ccc cca cgg aga cca agc cgt cat gac aac agt gca     2119
 Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser Arg His Asp Asn Ser Ala
     600                 605                 610

 att ggc aga gcc atg gaa cta cag aag gcg cgc cac cct aag cac tta     2167
 Ile Gly Arg Ala Met Glu Leu Gln Lys Ala Arg His Pro Lys His Leu
 615                 620                 625                 630

 tcc aca ccc tca tct gtg agt cct gaa cct cag gac tct gcc aag ttg     2215
 Ser Thr Pro Ser Ser Val Ser Pro Glu Pro Gln Asp Ser Ala Lys Leu
                 635                 640                 645

 cgc cag agt ggg tta gca aat gaa gga aca gac gct gga tac ctg cct     2263
 Arg Gln Ser Gly Leu Ala Asn Glu Gly Thr Asp Ala Gly Tyr Leu Pro
             650                 655                 660

 gcc aat tcc atg tct tct gta gct tca ggg gcc tct ttt tcc cag gaa     2311
 Ala Asn Ser Met Ser Ser Val Ala Ser Gly Ala Ser Phe Ser Gln Glu
         665                 670                 675

 gga ggg aaa gag aat gat aca gga tca aag caa gtt gga gaa aca tca     2359
 Gly Gly Lys Glu Asn Asp Thr Gly Ser Lys Gln Val Gly Glu Thr Ser
     680                 685                 690

 gca cct gga gac acc tta gat ggc aca cct cgt act ctc aat act gtc     2407
 Ala Pro Gly Asp Thr Leu Asp Gly Thr Pro Arg Thr Leu Asn Thr Val
 695                 700                 705                 710

 ttt gtt ttc cca cca cct cca tta gac caa gtg cag gag gag gaa tgt     2455
 Phe Val Phe Pro Pro Pro Pro Leu Asp Gln Val Gln Glu Glu Glu Cys
                 715                 720                 725

 gaa gta gaa agg gtg act gaa cat ggg aca cca aag ccc ttt cga aag     2503
 Glu Val Glu Arg Val Thr Glu His Gly Thr Pro Lys Pro Phe Arg Lys
             730                 735                 740

 ttt gac agt gta gct ttt gga gaa agt caa agt gag gat gaa caa ttt     2551
 Phe Asp Ser Val Ala Phe Gly Glu Ser Gln Ser Glu Asp Glu Gln Phe
         745                 750                 755

 gaa aat gac tta gag aca gat cca ccc aac tgg cag cag ctt gtt agt     2599
 Glu Asn Asp Leu Glu Thr Asp Pro Pro Asn Trp Gln Gln Leu Val Ser
     760                 765                 770

 cga gaa gtg tta ctg gga cta aaa cct tgt gaa atc aaa aga cag gaa     2647
 Arg Glu Val Leu Leu Gly Leu Lys Pro Cys Glu Ile Lys Arg Gln Glu
 775                 780                 785                 790

 gtg att aat gaa ttg ttc tac act gaa aga gct cat gtt cga aca ctg     2695
 Val Ile Asn Glu Leu Phe Tyr Thr Glu Arg Ala His Val Arg Thr Leu
                 795                 800                 805

 aag gtt ctt gat caa gtg ttc tat cag cga gta tcc aga gaa gga att     2743
 Lys Val Leu Asp Gln Val Phe Tyr Gln Arg Val Ser Arg Glu Gly Ile
             810                 815                 820

 ctg tca ccc tca gag cta tgg aaa att ttt tca aac ttg gaa gat att     2791
 Leu Ser Pro Ser Glu Leu Trp Lys Ile Phe Ser Asn Leu Glu Asp Ile
         825                 830                 835

 ctt caa ctt cat att gga ttg aat gaa caa atg aag gct gtt cga aag     2839
 Leu Gln Leu His Ile Gly Leu Asn Glu Gln Met Lys Ala Val Arg Lys
     840                 845                 850

 aga aat gag acc tct gtt atc gat cag att ggg gaa gat ttg ctg aca     2887
 Arg Asn Glu Thr Ser Val Ile Asp Gln Ile Gly Glu Asp Leu Leu Thr
 855                 860                 865                 870

 tgg ttc agc gga cca gga gag gag aaa ttg aaa cat gct gct gct acc     2935
 Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu Lys His Ala Ala Ala Thr
                 875                 880                 885

 ttt tgc agt aac caa cct ttc gcc ctg gaa atg atc aaa tct cgt cag     2983
 Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu Met Ile Lys Ser Arg Gln
             890                 895                 900

 aaa aag gat tct cga ttt cag act ttt gtg caa gat gct gaa agt aat     3031
 Lys Lys Asp Ser Arg Phe Gln Thr Phe Val Gln Asp Ala Glu Ser Asn
         905                 910                 915

 cca ctg tgt cgt cgt ctt caa ctg aag gat att att ccc act caa atg     3079
 Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp Ile Ile Pro Thr Gln Met
     920                 925                 930

 caa agg ctt act aag tac cca ctt ctg ttg gat aat att gcc aaa tac     3127
 Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu Asp Asn Ile Ala Lys Tyr
 935                 940                 945                 950

 aca gaa tgg cca aca gaa agg gag aag gtg aag aaa gct gca gat cac     3175
 Thr Glu Trp Pro Thr Glu Arg Glu Lys Val Lys Lys Ala Ala Asp His
                 955                 960                 965

 tgt cgt cag atc tta aat tat gta aat cag gct gtc aag gag gca gaa     3223
 Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln Ala Val Lys Glu Ala Glu
             970                 975                 980

 aat aag cag cgc cta gaa gat tat cag cgt cgc ctt gat acc tcc agc     3271
 Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg Arg Leu Asp Thr Ser Ser
         985                 990                 995

 ctg aag ttg tca gag tac cca aat gtt gaa gag ctc agg aat ttg gat     3319
 Leu Lys Leu Ser Glu Tyr Pro Asn Val Glu Glu Leu Arg Asn Leu Asp
    1000                1005                1010

 tta aca aaa agg aag atg att cat gaa ggg cca ttg gtt tgg aag gtg     3367
 Leu Thr Lys Arg Lys Met Ile His Glu Gly Pro Leu Val Trp Lys Val
1015                1020                1025                1030

 aat aga gat aaa act att gat tta tac acg ttg ctg ctg gaa gac att     3415
 Asn Arg Asp Lys Thr Ile Asp Leu Tyr Thr Leu Leu Leu Glu Asp Ile
                1035                1040                1045

 ctt gta ttg tta caa aag cag gat gat aga ctg gtt tta agg tgt cat     3463
 Leu Val Leu Leu Gln Lys Gln Asp Asp Arg Leu Val Leu Arg Cys His
            1050                1055                1060

 agt aag att ctg gca tct aca gct gat agc aaa cac acg ttt agc cct     3511
 Ser Lys Ile Leu Ala Ser Thr Ala Asp Ser Lys His Thr Phe Ser Pro
        1065                1070                1075

 gtc att aag ttg agt aca gtg ttg gtt cga caa ggg gca aca gat aac     3559
 Val Ile Lys Leu Ser Thr Val Leu Val Arg Gln Gly Ala Thr Asp Asn
    1080                1085                1090

 aaa gct tta ttc gtc att tcc atg tca gac aat ggc gct cag att tat     3607
 Lys Ala Leu Phe Val Ile Ser Met Ser Asp Asn Gly Ala Gln Ile Tyr
1095                1100                1105                1110

 gaa ctg gtg gca cag aca gtt tct gaa aag act gtc tgg cag gac cta     3655
 Glu Leu Val Ala Gln Thr Val Ser Glu Lys Thr Val Trp Gln Asp Leu
                1115                1120                1125

 atc tgt cgg atg gct gca tca gtg aag gag caa tcc aca aag cca att     3703
 Ile Cys Arg Met Ala Ala Ser Val Lys Glu Gln Ser Thr Lys Pro Ile
            1130                1135                1140

 cca tta cca cag tca aca cct ggc gaa gga gat aat gat gaa gaa gat     3751
 Pro Leu Pro Gln Ser Thr Pro Gly Glu Gly Asp Asn Asp Glu Glu Asp
        1145                1150                1155

 cct tca aaa tta aaa gag gag cag cat ggc att tca gtc act ggt ttg     3799
 Pro Ser Lys Leu Lys Glu Glu Gln His Gly Ile Ser Val Thr Gly Leu
    1160                1165                1170

 cag agt cca gac aga gat ttg gga tta gaa tct acc tta ata tcg tca     3847
 Gln Ser Pro Asp Arg Asp Leu Gly Leu Glu Ser Thr Leu Ile Ser Ser
1175                1180                1185                1190

 aaa cct cag tct cat tca ctg agt acc tct ggg aaa tca gag gta cgt     3895
 Lys Pro Gln Ser His Ser Leu Ser Thr Ser Gly Lys Ser Glu Val Arg
                1195                1200                1205

 gat ctg ttt gtg gct gag aga cag ttt gca aag gaa caa cat aca gat     3943
 Asp Leu Phe Val Ala Glu Arg Gln Phe Ala Lys Glu Gln His Thr Asp
            1210                1215                1220

 ggg aca cta aag gaa gtt gga gaa gat tat caa atc gca atc cca gat     3991
 Gly Thr Leu Lys Glu Val Gly Glu Asp Tyr Gln Ile Ala Ile Pro Asp
        1225                1230                1235

 tca cac ctg cct gtc tca gaa gaa cgg tgg gca ttg gat gca cta aga     4039
 Ser His Leu Pro Val Ser Glu Glu Arg Trp Ala Leu Asp Ala Leu Arg
    1240                1245                1250

 aat ttg ggt ttg ttg aag cag ttg ctg gtg caa cag cta ggt ttg act     4087
 Asn Leu Gly Leu Leu Lys Gln Leu Leu Val Gln Gln Leu Gly Leu Thr
1255                1260                1265                1270

 gag aag agc gtt cag gaa gac tgg caa cat ttc cca aga tac aga aca     4135
 Glu Lys Ser Val Gln Glu Asp Trp Gln His Phe Pro Arg Tyr Arg Thr
                1275                1280                1285

 gcc tct cag ggg ccg cag aca gac agt gtc atc cag aac tct gaa aat     4183
 Ala Ser Gln Gly Pro Gln Thr Asp Ser Val Ile Gln Asn Ser Glu Asn
            1290                1295                1300

 att aag gcc tat cat tct ggt gaa gga cat atg ccc ttt aga act gga     4231
 Ile Lys Ala Tyr His Ser Gly Glu Gly His Met Pro Phe Arg Thr Gly
        1305                1310                1315

 act ggt gac att gca act tgt tac agt cca cgg act tca act gaa tct     4279
 Thr Gly Asp Ile Ala Thr Cys Tyr Ser Pro Arg Thr Ser Thr Glu Ser
    1320                1325                1330

 ttt gct cca cgg gat tca gtg gga ctg gca ccc cag gat agc cag gca     4327
 Phe Ala Pro Arg Asp Ser Val Gly Leu Ala Pro Gln Asp Ser Gln Ala
1335                1340                1345                1350

 agt aac att tta gta atg gac cac atg att atg acc cca gag atg cct     4375
 Ser Asn Ile Leu Val Met Asp His Met Ile Met Thr Pro Glu Met Pro
                1355                1360                1365

 acc atg gag cca gaa ggg ggt ctt gat gac agt gga gag cac ttt ttt     4423
 Thr Met Glu Pro Glu Gly Gly Leu Asp Asp Ser Gly Glu His Phe Phe
            1370                1375                1380

 gat gcc cgt gaa gca cat agt gat gag aat cca tca gaa ggt gat gga     4471
 Asp Ala Arg Glu Ala His Ser Asp Glu Asn Pro Ser Glu Gly Asp Gly
        1385                1390                1395

 gca gtt aac aag gaa gag aag gat gtt aat tta cgc atc tca gga aac     4519
 Ala Val Asn Lys Glu Glu Lys Asp Val Asn Leu Arg Ile Ser Gly Asn
    1400                1405                1410

 tat ttg atc ctt gat ggc tat gac cca gtg cag gag agt tcc aca gat     4567
 Tyr Leu Ile Leu Asp Gly Tyr Asp Pro Val Gln Glu Ser Ser Thr Asp
1415                1420                1425                1430

 gag gag gtt gct tcc tca ctt acc ctg cag ccc atg aca ggc atc cct     4615
 Glu Glu Val Ala Ser Ser Leu Thr Leu Gln Pro Met Thr Gly Ile Pro
                1435                1440                1445

 gct gtg gaa tcc acc cac cag cag caa cat tct cct cag aat act cac     4663
 Ala Val Glu Ser Thr His Gln Gln Gln His Ser Pro Gln Asn Thr His
            1450                1455                1460

 tcc gat ggg gca att tca cca ttc acc ccc gaa ttt ctg gtc cag cag     4711
 Ser Asp Gly Ala Ile Ser Pro Phe Thr Pro Glu Phe Leu Val Gln Gln
        1465                1470                1475

 cgc tgg gga gct atg gag tat tcc tgt ttt gag atc cag agt ccc tcc     4759
 Arg Trp Gly Ala Met Glu Tyr Ser Cys Phe Glu Ile Gln Ser Pro Ser
    1480                1485                1490

 tct tgt gca gat tca cag agc cag atc atg gag tac att cat aag ata     4807
 Ser Cys Ala Asp Ser Gln Ser Gln Ile Met Glu Tyr Ile His Lys Ile
1495                1500                1505                1510

 gag gct gac ctt gaa cac tta aag aag gtg gag gaa agt tac acc att     4855
 Glu Ala Asp Leu Glu His Leu Lys Lys Val Glu Glu Ser Tyr Thr Ile
                1515                1520                1525

 ctt tgc caa agg ctg gct gga tca gcc ctc aca gac aag cac tca gat     4903
 Leu Cys Gln Arg Leu Ala Gly Ser Ala Leu Thr Asp Lys His Ser Asp
            1530                1535                1540

 aaa agt tag agccgca tgtcctggag gtgactgcag gttgttggat ttggagtatc     4959
 Lys Ser 


 ggccgtgtct caccacatcc tggctccagt gtggatgcag agagagtgtg acagaggatc   5019

 tgcctgtgaa ccacctggga ttagtcaagt cccaaggtgc ccagagtggg actagttctt   5079

 cacagtgtgg cagctgcact aatctgtttg tgagggaata tccattccct cactctactc   5139

 tcctcactat cggaaattca ttttgattca gaataaaaac caaatgtata gagctttggg   5199

 tgtaggatat gaaattgtac ttagatttaa gaaaaagaga aaatcagatg tatttatttg   5259

 acttcattcc gtatttgaaa gcacatttta atttttattt gccttgtttt gttttaattg   5319

 agtagtgaga gttttagacc tttgtcttta gtacacccaa ggatcaactg ctcctgaagc   5379

 aaagaggtca ggatggagta tgcagaagtt gggtagagag gttaagaaga ggaggaagtg   5439

 agacggggaa gggaggagca ccttgcttca ctatacagta ttccaagctc tctgctgtcc   5499

 agtaggctgc ttctctgagg gtcacctcaa aggtatgcta tgccgtgtgg ctcttatgtg   5559

 cccaggtggt gtggtcagag agtggatggg cttcctcccg ccctgaggca agcacctctt   5619

 ctctgtagct gggatcaacc acaattaata ggaatcctca acatactaaa tagcaggcac   5679

 ttgaaaatgg gtgtgttttc ttccattgtc gtcttttcta ttgagggttg ggatttgggt   5739

 gggagaggaa agcaaatttt attttcttga ctataaattt gttattcttg gtatcatttc   5799

 atttttataa ttatacatta gacattggca cttgtgtaaa actgtccctg cagattgagc   5859

 aggaagtaaa aacaaatgga aatgcttcgg atagtggcag gggtgggggt tgctaaggaa   5919

 agggtgggat gggagtgggt aaagagtttg ggaaggttat ctaactgaat cactactgag   5979

 ttgaatcatg gctatcatta gccacaggta ctgctgatta taaggccagt aaaattttag   6039

 tacctggagg tttgactcta atttttgcac tgatggtgcc aaagggccct gagtcaaaag   6099

 gatagccaag ggtggagtgg aaaaagatat ggtgaaggca gaactgctca caccagctcc   6159

 agaagcacgt cctctgactt cactgccgca gctctttcca cacggggccg tgattgaccc   6219

 taaaaattgc agaccagcac atacactgga cactgcaggc aaggtgttgg taactgcctg   6279

 ctctaggatg aatagtagcg ttagcagcac cctacagagg gtaagtttca gaattgtaat   6339

 ttgagaactc cttcaattat attgactttc tttggttttc cttgtgcatt aggtatatat   6399

 tttttgaagt atttttgcca actaaaatga agtctgtaaa ttctgttaat aaacaaggag   6459

 ttcatccgtt gctcacatct ttcattggtg ccctctgaac tctgtgggtt gctaggatgt   6519

 aattttaatg cttccctgca gtccaaagat gattttttca ccacaaatgg taagggatgc   6579

 ccacctactt ttataaacac cactgcaact taacaagttt atttatctat gtccagattt   6639

 ctgtttctgt cctaaattga tctgtgtttt taggtggatc aacttggatc tttagacctc   6699

 atctataaat tgaaattata tttttagtca taagccaagt acaatctaac tcagaatggg   6759

 attaaaaatt ttagaagcag aagctaatat ataaatgaag tttgggattt ggaactttct   6819

 gtatctctta ggaggaacaa gtaaaaacca aatggttaca ttgtgctgct agaaataatg   6879

 tcattctcaa ttaaaagggt tacacctgta gccacttgac actaacacca tcgagggcaa   6939

 ttaatcagga gaaaagtaaa tataaaaact ttgctcttaa cgtcacacac tacagggtaa   6999

 ttatgtaatt ctctagcact caattaagaa gcttgtaggt tagcaaaatt tcagtttctc   7059

 tagttcagcc agtgtcttgt ccttagtaat tatttgcttt ccctgcagtt caatttctcc   7119

 ttggaactct aacaggacta actggaaaaa tactttgacc atagctctag tacttccaaa   7179

 taaattcata tctagatttt caaacaaagc cccaagatga agtctaattc tgaaaatatc   7239

 tcacaatttt tgaatgttct ttttatctta ccgacctaac ttctcttttc cctcccaact   7299

 tggcctccca cacgttccat ttcattttgg ccattatagt cacatccgtt tgactttggt   7359

 tgtgacatct tcctttcagg atgatggaat tagatgcagt ctgtctttga gtgagactgg   7419

 tcaccatcag aggagttttt tctaagtgac gtgactagaa gttgaaatct acttccctgc   7479

 taaagggcac aggggtggtg tacaaagaaa gctaccttcc cagagcaagc aggctgcatt   7539

 ttagctatgg aagtgacctg ctgtgacact gtgctctctt ctgtgggctt aatggttcct   7599

 ttgctatgaa gtggcaaatt acatgtagag tgtctccttc cttttcagag aacagttaat   7659

 caaggcaaat cagcaagccc ccaaagtgct gtaatttaac atcatgatta ccaccttcga   7719

 agctatatat tttgcatact ttaaaatcac ctaacttgga ctgcttgaat tacattggct   7779

 tttagaaccg aaattgtaac tatgtattgt atttcatggg aggtatattt tatgagcttt   7839

 ttggctttct tttttcccac agcaactgcc aatgaaggat gaatcccctt tttaaaaagt   7899

 tgttgttgtt gttgtttatt tgattttgag ttaggaggga taatagagaa gtccatttaa   7959

 aaattatttt tagaagctaa agaaagtaat tatgcttcct gtgaattgtc ttttactggc   8019

 atctttgttt tcctctttga tgttagtaaa tttggtgtaa tacgtggggc ttccatattt   8079

 caaagtggaa gctttcttct ctgaagtcga tatatggttt tgaattacta gagctttggt   8139

 cagtatttcc ttccctatat gtcacagagg gcaccactga gaactgcgtg cataggacct   8199

 caaaatacaa aattagcagg gcctcacagt cagcttcctc atggctagtt tttccccctt   8259

 atattacaat ttttgtttta taagtcattt ttttcctgat atttccacca cttttcagag   8319

 tcatctacaa aatttttctt tcctcaagaa aagagttcct tttgccttat tccttatgcc   8379

 ttccccactg gtattgaggg ttttgataat aaattggtag gaaaaaaaag tacctcctag   8439

 aaggaagcct tccccaccat ttccaggtgc caactgctaa gcagatatat tccaaaaatg   8499

 gtaactgtca tgtgcacact gttggttatt tttaataagc ctcttcctac tagaacattt   8559

 tattttcctt gttcaccata caatcatgta ctctttaaca gaaattgctt ttaaaaaata   8619

 tctggaacta tctttaaaaa aactttatta ataatcatgt atttttactg atcacatttt   8679

 gaaatgccta aaagacttta ttgttctaat tatccagatg tacctttgta aaatagctct   8739

 tttatgaatt agctgataag gctgtatgtt tctggaacaa aatattggtc atctaaaaac   8799

 tttctgtttt ctggggtctg ggaaaataga aaataagatt tcaaatatta aataagctta   8859

 aaggaaccaa gcatgtgact tttactttgt attctggttg atttgtcttg tccaagttat   8919

 attagaaaag ttgaggagtc gaggagcctg taattaattt tcctgtcagt gactgtcaga   8979

 catcttcctg cttattagag catccctagc aacaaggcta aaccttcatg acagtgctgg   9039

 caggtgggct tgccctagca tgtggggcag gttttttttt tttttaatag ctttattgag   9099

 atattcacat atcatataat tcatccattt aaagtgtata atcagatggg ttttggtata   9159

 ttattgattt ttaattgtgg tgaaatatat atataacaaa atttgctatt gtaactattt   9219

 ttaagtataa agttcagtga ggtaggccag cttttatgac gcacctgaag ataactttgg   9279

 ttttaatcct accctaaatg aagcatatgc ctctattttt cctgtcccca gtgctgggct   9339

 tcttcacata ccaacatttc tgtgctttta ccaacagcat tttagctcag aaggctcgct   9399

 tactttgggc atttgctgta ttttggtttt gaaatacttg taatttgact tattcttggg   9459

 ataatatttt agttttcagt cattcaaggg cacatttggc tgacggagct aataagcgta   9519

 ataaaatgct tagtagttta taccatcttt tagttaaaca ttttaaagat taagactatt   9579

 caaatgtact ttgcggaaat taacctgttt gtatgcctgg ctttgtttac aaacatatat   9639

 ctatatctat atatatagat acagatacag atacatatct ggtggaacaa agaaatacct   9699

 gtaccattcc cacttgctct ttgatagcca cctcctagga atggagacaa taaaactctg   9759

 tatttgcatg tgaaaaaaaa aaaa                                          9783




      <210> 41
      <211> 2235
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(1562)

      <220>
      <221> misc_feature
      <222> (1)...(2235)
      <223> n = a,t,c or g

      <400> 41
 aaaggtcagg agcagtaact ggagcagtaa ctcagaagtt ccctgaaaag aaagagaaga     60

 gctgccccag acatctgaga gcatcattaa cacctgtgac c    atg atg ggt caa     113
                                                  Met Met Gly Gln
                                                    1

 gac aaa ata caa ggc cac tct gta atc agt gaa gaa tct gat gga aag      161
 Asp Lys Ile Gln Gly His Ser Val Ile Ser Glu Glu Ser Asp Gly Lys
   5                  10                  15                  20

 ctt att gaa gac agc ctg att cag ctg aga tgt cac ttt aca tgg aag      209
 Leu Ile Glu Asp Ser Leu Ile Gln Leu Arg Cys His Phe Thr Trp Lys
                  25                  30                  35

 ttg tta att gaa gcc cct gaa att cct gat tta gaa aac agg atc tgg      257
 Leu Leu Ile Glu Ala Pro Glu Ile Pro Asp Leu Glu Asn Arg Ile Trp
              40                  45                  50

 gaa gag att cag ttc ctg gac acc aaa tac aat gtg gga ata cac aac      305
 Glu Glu Ile Gln Phe Leu Asp Thr Lys Tyr Asn Val Gly Ile His Asn
          55                  60                  65

 cta cta gcc tat gtg aaa cac ctg aaa ggc cag aat gag gaa gcc ctg      353
 Leu Leu Ala Tyr Val Lys His Leu Lys Gly Gln Asn Glu Glu Ala Leu
      70                  75                  80

 gtc agc ttg aaa aag gct gaa gac tta att cag aaa gaa cat gcc aac      401
 Val Ser Leu Lys Lys Ala Glu Asp Leu Ile Gln Lys Glu His Ala Asn
  85                  90                  95                 100

 caa gca gat att aga agt ctg gtg acc tgg ggc aac ttt gcc tgg gtg      449
 Gln Ala Asp Ile Arg Ser Leu Val Thr Trp Gly Asn Phe Ala Trp Val
                 105                 110                 115

 tat tac cac atg ggc aga ttg gca gaa gcc cag act tac ctg gac aag      497
 Tyr Tyr His Met Gly Arg Leu Ala Glu Ala Gln Thr Tyr Leu Asp Lys
             120                 125                 130

 gtg gag aac act tgc aag aag ttt gca aat cct tcc cgc tat aga atg      545
 Val Glu Asn Thr Cys Lys Lys Phe Ala Asn Pro Ser Arg Tyr Arg Met
         135                 140                 145

 gag tgt cca gag gtg gac tgt gag gaa gga tgg gcc ttg gcg aag tgt      593
 Glu Cys Pro Glu Val Asp Cys Glu Glu Gly Trp Ala Leu Ala Lys Cys
     150                 155                 160

 gga gga aag aat tat gaa cgg gcc aag acc tgc ttt gaa aag gct ctg      641
 Gly Gly Lys Asn Tyr Glu Arg Ala Lys Thr Cys Phe Glu Lys Ala Leu
 165                 170                 175                 180

 gaa ggg aac cct gaa aac cct gaa ttc aat act ggg tac gca atc acc      689
 Glu Gly Asn Pro Glu Asn Pro Glu Phe Asn Thr Gly Tyr Ala Ile Thr
                 185                 190                 195

 gtc tat cgc ctg gat aaa ttt aac aca gca tca ggg agg aat aag gca      737
 Val Tyr Arg Leu Asp Lys Phe Asn Thr Ala Ser Gly Arg Asn Lys Ala
             200                 205                 210

 ttt tct ctg cac gtc cta aaa cga gct gtc agg cta aat cca gat gat      785
 Phe Ser Leu His Val Leu Lys Arg Ala Val Arg Leu Asn Pro Asp Asp
         215                 220                 225

 gta tat att agg gtt ctc ctt gcc ctg aag ctt cag gat gaa gga cag      833
 Val Tyr Ile Arg Val Leu Leu Ala Leu Lys Leu Gln Asp Glu Gly Gln
     230                 235                 240

 gaa gct gaa gga gaa aag tac att gaa gaa gct ctg acc agt ata tct      881
 Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu Ala Leu Thr Ser Ile Ser
 245                 250                 255                 260

 tca cag gcc tat gtc ttt caa tat gca gcc aag ttt tat cga aga aaa      929
 Ser Gln Ala Tyr Val Phe Gln Tyr Ala Ala Lys Phe Tyr Arg Arg Lys
                 265                 270                 275

 ggg tct gtg gat aaa gct ctt gag ctc tta aaa atg gcc ttg gag aca      977
 Gly Ser Val Asp Lys Ala Leu Glu Leu Leu Lys Met Ala Leu Glu Thr
             280                 285                 290

 aca ccc act tct gcc ttc ctg cat cac caa atg ggg ctt tgc tac agg     1025
 Thr Pro Thr Ser Ala Phe Leu His His Gln Met Gly Leu Cys Tyr Arg
         295                 300                 305

 gca caa atg atc caa atc aag gaa gct aca aac tgg cag cct aga ggg     1073
 Ala Gln Met Ile Gln Ile Lys Glu Ala Thr Asn Trp Gln Pro Arg Gly
     310                 315                 320

 caa gat agg gaa act gtg gac aga ttg gtt caa ttg gct ata tgc aaa     1121
 Gln Asp Arg Glu Thr Val Asp Arg Leu Val Gln Leu Ala Ile Cys Lys
 325                 330                 335                 340

 ttt gaa aag act ata atg tta aag cga aca ttt gag atg gcc tat gtt     1169
 Phe Glu Lys Thr Ile Met Leu Lys Arg Thr Phe Glu Met Ala Tyr Val
                 345                 350                 355

 gac ctg gct gaa acg tat gca gaa ata ggc cac cac aga aag gct gag     1217
 Asp Leu Ala Glu Thr Tyr Ala Glu Ile Gly His His Arg Lys Ala Glu
             360                 365                 370

 gaa cat ttt cag aaa ggg tta cgc atg aag atc ttt gaa gat cag cta     1265
 Glu His Phe Gln Lys Gly Leu Arg Met Lys Ile Phe Glu Asp Gln Leu
         375                 380                 385

 aag caa gag att cat tac cac tac ggc cgt ttc caa gaa cat cat ggg     1313
 Lys Gln Glu Ile His Tyr His Tyr Gly Arg Phe Gln Glu His His Gly
     390                 395                 400

 aaa tct caa gat aaa gca att acc cat tat tta aaa ggt ttg aaa ata     1361
 Lys Ser Gln Asp Lys Ala Ile Thr His Tyr Leu Lys Gly Leu Lys Ile
 405                 410                 415                 420

 gaa aaa atg tcc cat tcc agg gaa aaa ctt ctc aat gct tta gag aaa     1409
 Glu Lys Met Ser His Ser Arg Glu Lys Leu Leu Asn Ala Leu Glu Lys
                 425                 430                 435

 ttg gct aaa aga tgt att cac cag aat gta cgg gtt gtg gaa agt gtc     1457
 Leu Ala Lys Arg Cys Ile His Gln Asn Val Arg Val Val Glu Ser Val
             440                 445                 450

 agc ctc ctt ggg ctt atc cac aaa ttg aaa gga gaa gta agt gat gct     1505
 Ser Leu Leu Gly Leu Ile His Lys Leu Lys Gly Glu Val Ser Asp Ala
         455                 460                 465

 ttg ctg tgc tat gag agg gct ctg agg ctg gct gct gac ctg aac cct     1553
 Leu Leu Cys Tyr Glu Arg Ala Leu Arg Leu Ala Ala Asp Leu Asn Pro
     470                 475                 480

 ata ttt taa catagag gtcaccatta tccatttaat ggtcttataa ctaaatagaa     1609
 Ile Phe 
 485

 tgactatgaa attaaataat gcaaacttaa agctgttgga aatttacctt attttgagcc   1669

 ttgagaggaa tgtggctgtg tggcctgagt tatgtagcat gcaactgcaa cttctgcttt   1729

 ttcctgtaaa tgatcaggaa aggccttgtg gcaccagaca taagaccccc tgaaagtatc   1789

 atccctcctg atggaatggt aaagcaatct ttcttggaac atagcaagta gtaaccgatc   1849

 aaattgctat aacgtgtgta ctgaccttat gtggaaaatg ctgcaaccct gtttactgcc   1909

 tatgtaagtg aaatcttaac ttccccattt tggaatgctg actccagtca ttaggtgtct   1969

 gtatttcctg agtggttacc ctcaagcttt gtgctcaaat aaactctata cttaatgtcg   2029

 acgcggccgc gaagctgtcg ttgttctgag aattctggca gctggcttct ttggctcgtt   2089

 attatgtctg tgagatttat tcatgttgct gtgcgtagta tagtttgtgc caactcccgc   2149

 ccnaccaaac tgtgtctgtc acttctaata cataccattg ctcagctgag cagatttcat   2209

 tgatctctaa caacgaccct gctctc                                        2235




      <210> 42
      <211> 1671
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (417)..(1628)

      <400> 42
 tttcgtccgg aacggcggca cggggttgtt gtgggggtca gtcccccggg gactggaggg     60

 agacgcggca cgcggcctct gcgaccctat gaactctgac cccagctccc acactgtcgc    120

 ctatcaccgg cccactctcc gtgccgcgtg tcccttaaaa gctggggcct gggacaggaa    180

 cgacagacaa tgcagccaat ggcgtcacgc gcggtgcccc gctacccaat cgaaaggcgt    240

 ggctgaggga aacgcggtgg gaaccgcccc cgactccagg cgactccttg gccgggcggg    300

 ggagagcgtc cccgtcagct gagagcatcc tcactcggtc agttcctcgg gcgagttacg    360

 gggacgacct gcgggagcac gcgggcagtg gccggacgct gaagcccagg agagcg        416                                                                 
 atg gag acg tat gcg gag gtt ggg aag gag ggc aag cct tcc tgt gca      464
 Met Glu Thr Tyr Ala Glu Val Gly Lys Glu Gly Lys Pro Ser Cys Ala
   1               5                  10                  15

 tcg gtg gat ctg cag gga gac agc tcc tta cag gtg gag att tct gac      512
 Ser Val Asp Leu Gln Gly Asp Ser Ser Leu Gln Val Glu Ile Ser Asp
              20                  25                  30

 gca gtg agt gag cgg gac aag gtg aaa ttc act gtt caa aca aag agc      560
 Ala Val Ser Glu Arg Asp Lys Val Lys Phe Thr Val Gln Thr Lys Ser
          35                  40                  45

 tgc ctc cct cac ttc gcc cag acc gag ttc tca gtc gtg cgg cag cac      608
 Cys Leu Pro His Phe Ala Gln Thr Glu Phe Ser Val Val Arg Gln His
      50                  55                  60

 gag gag ttc atc tgg ctg cat gat gcc tac gtg gag aat gag gag tac      656
 Glu Glu Phe Ile Trp Leu His Asp Ala Tyr Val Glu Asn Glu Glu Tyr
  65                  70                  75                  80

 gcc ggc ctc atc atc ccc cca gcc cct ccg agg cca gac ttt gag gct      704
 Ala Gly Leu Ile Ile Pro Pro Ala Pro Pro Arg Pro Asp Phe Glu Ala
                  85                  90                  95

 tcg agg gaa aag cta cag aaa ttg ggc gag ggg gac agc tct gtc act      752
 Ser Arg Glu Lys Leu Gln Lys Leu Gly Glu Gly Asp Ser Ser Val Thr
             100                 105                 110

 cgg gaa gag ttt gcc aag atg aag cag gag ctg gaa gcg gag tac ctg      800
 Arg Glu Glu Phe Ala Lys Met Lys Gln Glu Leu Glu Ala Glu Tyr Leu
         115                 120                 125

 gcc atc ttt aag aag aca gtt gcg atg cac gaa gtc ttt ctg cag cgc      848
 Ala Ile Phe Lys Lys Thr Val Ala Met His Glu Val Phe Leu Gln Arg
     130                 135                 140

 ctg gcg gcc cac ccc acc ctg cgt cga gac cac aac ttc ttt gtg ttt      896
 Leu Ala Ala His Pro Thr Leu Arg Arg Asp His Asn Phe Phe Val Phe
 145                 150                 155                 160

 ttg gaa tat gga cag gat ctg agt gtc cgg ggg aag aac agg aag gag      944
 Leu Glu Tyr Gly Gln Asp Leu Ser Val Arg Gly Lys Asn Arg Lys Glu
                 165                 170                 175

 ctc ctc gga ggg ttt ctg agg aat att gtg aag tcc gcg gat gaa gcc      992
 Leu Leu Gly Gly Phe Leu Arg Asn Ile Val Lys Ser Ala Asp Glu Ala
             180                 185                 190

 ctc atc acg ggc atg tca ggg ctc aag gag gtg gat gac ttc ttt gag     1040
 Leu Ile Thr Gly Met Ser Gly Leu Lys Glu Val Asp Asp Phe Phe Glu
         195                 200                 205

 cat gag agg acc ttc ctg ttg gag tat cac acc cgt atc cga gat gcc     1088
 His Glu Arg Thr Phe Leu Leu Glu Tyr His Thr Arg Ile Arg Asp Ala
     210                 215                 220

 tgc ctg cgg gcc gac cgc gtc atg cgc gcc cac aag tgc ctg gca gac     1136
 Cys Leu Arg Ala Asp Arg Val Met Arg Ala His Lys Cys Leu Ala Asp
 225                 230                 235                 240

 gat tat atc cct atc tca gct gcg ctg agc agt ctg gga aca cag gaa     1184
 Asp Tyr Ile Pro Ile Ser Ala Ala Leu Ser Ser Leu Gly Thr Gln Glu
                 245                 250                 255

 gtc aac cag cta agg acg agc ttc ctc aaa ttg gca gag ctc ttt gaa     1232
 Val Asn Gln Leu Arg Thr Ser Phe Leu Lys Leu Ala Glu Leu Phe Glu
             260                 265                 270

 cgg ctg agg aag ctg gag ggc cgg gtg gct tcc gat gag gac ctg aag     1280
 Arg Leu Arg Lys Leu Glu Gly Arg Val Ala Ser Asp Glu Asp Leu Lys
         275                 280                 285

 ctg tca gac atg ctg agg tac tac atg cgt gac tca cag gca gcc aag     1328
 Leu Ser Asp Met Leu Arg Tyr Tyr Met Arg Asp Ser Gln Ala Ala Lys
     290                 295                 300

 gac ctg ctg tac cgg cgg ctg cgg gca ctg gcc gac tac gag aat gcc     1376
 Asp Leu Leu Tyr Arg Arg Leu Arg Ala Leu Ala Asp Tyr Glu Asn Ala
 305                 310                 315                 320

 aac aag gcg ctg gac aag gcg cgc acc agg aac cgg gag gtg cgg ccc     1424
 Asn Lys Ala Leu Asp Lys Ala Arg Thr Arg Asn Arg Glu Val Arg Pro
                 325                 330                 335

 gcc gag agc cac cag cag ctg tgc tgc caa cgc ttc gag cgc ctc tcc     1472
 Ala Glu Ser His Gln Gln Leu Cys Cys Gln Arg Phe Glu Arg Leu Ser
             340                 345                 350

 gac tcc gcc aag caa gag ctc atg gac ttc aag tcc cgc cgg gtc tcc     1520
 Asp Ser Ala Lys Gln Glu Leu Met Asp Phe Lys Ser Arg Arg Val Ser
         355                 360                 365

 tct ttt cga aag aat ctc att gag ctg gca gag ctg gag ctc aaa cac     1568
 Ser Phe Arg Lys Asn Leu Ile Glu Leu Ala Glu Leu Glu Leu Lys His
     370                 375                 380

 gcc aag gcc agc acc ctg att ctc cgg aac acc ctt gtt gcc cta aag     1616
 Ala Lys Ala Ser Thr Leu Ile Leu Arg Asn Thr Leu Val Ala Leu Lys
 385                 390                 395                 400

 ggg gag cct tag agt agccagagct cagccagacc ctaatctggg atctccagtg     1671
 Gly Glu Pro 






      <210> 43
      <211> 1049
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(999)

      <400> 43
 taggtagagg ccgggtgtta atcggccgag ggtggaggag ggagagacgc tggcccggga     60

 cccgaggggc gtgggcatcg ggaggcgggc ccgggttagg ggcgggaccg ccgcctggtt    120

 aaaggcgctt atttcccagg cagccgctgc agtcgccaca cctttgcccc tgctgcg       177                                                                 
 atg acc ctg tcg cca ctt ctg ctg ttc ctg cca ccg ctg ctg ctg ctg      225
 Met Thr Leu Ser Pro Leu Leu Leu Phe Leu Pro Pro Leu Leu Leu Leu
   1               5                  10                  15

 ctg gac gtc ccc acg gcg gcg gtg cag gcg tcc cct ctg caa gcg tta      273
 Leu Asp Val Pro Thr Ala Ala Val Gln Ala Ser Pro Leu Gln Ala Leu
              20                  25                  30

 gac ttc ttt ggg aat ggg cca cca gtt aac tac aag aca ggc aat cta      321
 Asp Phe Phe Gly Asn Gly Pro Pro Val Asn Tyr Lys Thr Gly Asn Leu
          35                  40                  45

 tac ctg cgg ggg ccc ctg aag aag tcc aat gca ccg ctt gtc aat gtg      369
 Tyr Leu Arg Gly Pro Leu Lys Lys Ser Asn Ala Pro Leu Val Asn Val
      50                  55                  60

 acc ctc tac tat gaa gca ctg tgc ggt ggc tgc cga gcc ttc ctg atc      417
 Thr Leu Tyr Tyr Glu Ala Leu Cys Gly Gly Cys Arg Ala Phe Leu Ile
  65                  70                  75                  80

 cgg gag ctc ttc cca aca tgg ctg ttg gtc atg gag atc ctc aat gtc      465
 Arg Glu Leu Phe Pro Thr Trp Leu Leu Val Met Glu Ile Leu Asn Val
                  85                  90                  95

 acg ctg gtg ccc tac gga aac gca cag gaa caa aat gtc agt ggc agg      513
 Thr Leu Val Pro Tyr Gly Asn Ala Gln Glu Gln Asn Val Ser Gly Arg
             100                 105                 110

 tgg gag ttc aag tgc cag cat gga gaa gag gag tgc aaa ttc aac aag      561
 Trp Glu Phe Lys Cys Gln His Gly Glu Glu Glu Cys Lys Phe Asn Lys
         115                 120                 125

 gtg gag gcc tgc gtg ttg gat gaa ctt gac atg gag cta gcc ttc ctg      609
 Val Glu Ala Cys Val Leu Asp Glu Leu Asp Met Glu Leu Ala Phe Leu
     130                 135                 140

 acc att gtc tgc atg gaa gag ttt gag gac atg gag aga agt ctg cca      657
 Thr Ile Val Cys Met Glu Glu Phe Glu Asp Met Glu Arg Ser Leu Pro
 145                 150                 155                 160

 cta tgc ctg cag ctc tac gcc cca ggg ctg tcg cca gac act atc atg      705
 Leu Cys Leu Gln Leu Tyr Ala Pro Gly Leu Ser Pro Asp Thr Ile Met
                 165                 170                 175

 gag tgt gca atg ggg gac cgc ggc atg cag ctc atg cac gcc aac gcc      753
 Glu Cys Ala Met Gly Asp Arg Gly Met Gln Leu Met His Ala Asn Ala
             180                 185                 190

 cag cgg aca gat gct ctc cag cca cca cac gag tat gtg ccc tgg gtc      801
 Gln Arg Thr Asp Ala Leu Gln Pro Pro His Glu Tyr Val Pro Trp Val
         195                 200                 205

 acc gtc aat ggg aaa ccc ctt gga aga tca gac cca gct cct tac cct      849
 Thr Val Asn Gly Lys Pro Leu Gly Arg Ser Asp Pro Ala Pro Tyr Pro
     210                 215                 220

 tgt ctg cca gtt gta cca ggg caa gaa gcc gga tgt ctg ccc ttc ctc      897
 Cys Leu Pro Val Val Pro Gly Gln Glu Ala Gly Cys Leu Pro Phe Leu
 225                 230                 235                 240

 aac cag ctc cct cag gag tgt ttg ctt caa gtg atg gcc ggt gag ctg      945
 Asn Gln Leu Pro Gln Glu Cys Leu Leu Gln Val Met Ala Gly Glu Leu
                 245                 250                 255

 cgg aga gct cat gga agg cga gtg gga acc cgg ctg cct gcc ttt ttt      993
 Arg Arg Ala His Gly Arg Arg Val Gly Thr Arg Leu Pro Ala Phe Phe
             260                 265                 270

 ttc tga tccagaccct cggcacctgc tgcttaccaa ctggaaaatt ttatgcatcc      1049
 Phe 






      <210> 44
      <211> 2753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2421)

      <400> 44
  atg gcg gta cgc gcg ttg aag ctg ctg acc aca ctg ctg gct gtc gtg      48
  Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val
    1               5                  10                  15

 gcc gct gcc tcc caa gcc gag gtc gag tcc gag gca gga tgg ggc atg       96
 Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met
              20                  25                  30

 gtg acg cct gat ctg ctc ttc gcc gag ggg acc gca gcc tac gcg cgc      144
 Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg
          35                  40                  45

 ggg gac tgg ccc ggg gtg gtc ctg agc atg gaa cgg gcg ctg cgc tcc      192
 Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser
      50                  55                  60

 cgg gca gcc ctc cgc gcc ctt cgc ctg cgc tgc cgc acc cag tgt gcc      240
 Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala
  65                  70                  75                  80

 gcc gac ttc ccg tgg gag ctg gac ccc gac tgg tcc ccc agc ccg gcc      288
 Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala
                  85                  90                  95

 cag gcc tcg ggc gcc gcc gcc ctg cgc gac ctg agc ttc ttc ggg ggc      336
 Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly
             100                 105                 110

 ctt ctg cgt cgc gct gcc tgc ctg cgc cgc tgc ctc ggg ccg ccg gcc      384
 Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala
         115                 120                 125

 gcc cac tcg ctc agc gaa gag atg gag ctg gag ttc cgc aag cgg agc      432
 Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser
     130                 135                 140

 ccc tac aac tac ctg cag gtc gcc tac ttc aag gtg cag acc tgc ctg      480
 Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Val Gln Thr Cys Leu
 145                 150                 155                 160

 gaa cca ggc ggc cgg ggt cct tct ggg gag agg agt gtt gca ggg gac      528
 Glu Pro Gly Gly Arg Gly Pro Ser Gly Glu Arg Ser Val Ala Gly Asp
                 165                 170                 175

 ctg agg agc ttg ggg gat cgg gga agt gtc cgc agg gag ggg aaa gtg      576
 Leu Arg Ser Leu Gly Asp Arg Gly Ser Val Arg Arg Glu Gly Lys Val
             180                 185                 190

 gcc tcc tgg ctg ggg agc tct cct cgg agc cgg gga gag ctg ctc cct      624
 Ala Ser Trp Leu Gly Ser Ser Pro Arg Ser Arg Gly Glu Leu Leu Pro
         195                 200                 205

 ggc agg aga cct tcc tcg ccc agt tcg cat ggg cag atg cta acc cca      672
 Gly Arg Arg Pro Ser Ser Pro Ser Ser His Gly Gln Met Leu Thr Pro
     210                 215                 220

 aag atc aac aag ttg gag aaa gct gtt gct gca gca cac acc ttc ttc      720
 Lys Ile Asn Lys Leu Glu Lys Ala Val Ala Ala Ala His Thr Phe Phe
 225                 230                 235                 240

 gtg ggc aat cct gag cac atg gaa atg cag cag aac cta gac tat tac      768
 Val Gly Asn Pro Glu His Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr
                 245                 250                 255

 caa acc atg tct gga gtg aag gag gcc gac ttc aag gat ctt gag act      816
 Gln Thr Met Ser Gly Val Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr
             260                 265                 270

 caa ccc cat atg caa gaa ttt cga ctg gga gtg cga ctc tac tca gag      864
 Gln Pro His Met Gln Glu Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu
         275                 280                 285

 gaa cag cca cag gaa gct gtg ccc cac cta gag gcg gcg ctg caa gaa      912
 Glu Gln Pro Gln Glu Ala Val Pro His Leu Glu Ala Ala Leu Gln Glu
     290                 295                 300

 tac ttt gtg gcc tat gag gag tgc cgt gcc ctc tgc gaa ggg ccc tat      960
 Tyr Phe Val Ala Tyr Glu Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr
 305                 310                 315                 320

 gac tac gat ggc tac aac tac ctt gag tac aac gct gac ctc ttc cag     1008
 Asp Tyr Asp Gly Tyr Asn Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln
                 325                 330                 335

 gcc atc aca gat cat tac atc cag gtc ctc aac tgt aag cag aac tgt     1056
 Ala Ile Thr Asp His Tyr Ile Gln Val Leu Asn Cys Lys Gln Asn Cys
             340                 345                 350

 gtc acg gag ctt gct tcc cac cca agt cga gag aag ccc ttt gaa gac     1104
 Val Thr Glu Leu Ala Ser His Pro Ser Arg Glu Lys Pro Phe Glu Asp
         355                 360                 365

 ttc ctc cca tcg cat tat aat tat ctg cag ttt gcc tac tat aac att     1152
 Phe Leu Pro Ser His Tyr Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile
     370                 375                 380

 ggg aat tat aca cag gct gtt gaa tgt gcc aag acc tat ctt ctc ttc     1200
 Gly Asn Tyr Thr Gln Ala Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe
 385                 390                 395                 400

 ttc ccc aat gac gag gtg atg aac caa aat ttg gcc tat tat gca gct     1248
 Phe Pro Asn Asp Glu Val Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala
                 405                 410                 415

 atg ctt gga gaa gaa cac acc aga tcc atc ggc ccc cgt gag agt gcc     1296
 Met Leu Gly Glu Glu His Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala
             420                 425                 430

 aag gag tac cga cag cga agc cta ctg gaa aaa gaa ctg ctt ttc ttc     1344
 Lys Glu Tyr Arg Gln Arg Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe
         435                 440                 445

 gct tat gat gtt ttt gga att ccc ttt gtg gat ccg gat tca tgg act     1392
 Ala Tyr Asp Val Phe Gly Ile Pro Phe Val Asp Pro Asp Ser Trp Thr
     450                 455                 460

 cca gaa gaa gtg att ccc aag aga ttg caa gag aaa cag aag tca gaa     1440
 Pro Glu Glu Val Ile Pro Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu
 465                 470                 475                 480

 cgg gaa aca gcc gta cgc atc tcc cag gag att ggg aac ctt atg aag     1488
 Arg Glu Thr Ala Val Arg Ile Ser Gln Glu Ile Gly Asn Leu Met Lys
                 485                 490                 495

 gaa atc gag acc ctt gtg gaa gag aag acc aag gag tca ctg gat gtg     1536
 Glu Ile Glu Thr Leu Val Glu Glu Lys Thr Lys Glu Ser Leu Asp Val
             500                 505                 510

 agc aga ctg acc cgg gaa ggt ggc ccc ctg ctg tat gaa ggc atc agt     1584
 Ser Arg Leu Thr Arg Glu Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser
         515                 520                 525

 ctc acc atg aac tcc aaa ctc ctg aat ggt tcc cag cgg gtg gtg atg     1632
 Leu Thr Met Asn Ser Lys Leu Leu Asn Gly Ser Gln Arg Val Val Met
     530                 535                 540

 gac ggc gta atc tct gac cac gag tgt cag gag ctg cag aga ctg acc     1680
 Asp Gly Val Ile Ser Asp His Glu Cys Gln Glu Leu Gln Arg Leu Thr
 545                 550                 555                 560

 aat gtg gca gca acc tca gga gat ggc tac cgg ggt cag acc tcc cca     1728
 Asn Val Ala Ala Thr Ser Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro
                 565                 570                 575

 cat act ccc aat gaa aag ttc tat ggt gtc act gtc ttc aaa gcc ctc     1776
 His Thr Pro Asn Glu Lys Phe Tyr Gly Val Thr Val Phe Lys Ala Leu
             580                 585                 590

 aag ctg ggg caa gaa ggc aaa gtt cct ctg cag agt gcc cac ctg tac     1824
 Lys Leu Gly Gln Glu Gly Lys Val Pro Leu Gln Ser Ala His Leu Tyr
         595                 600                 605

 tac aac gtg acg gag aag gtg cgg cgc atc atg gag tcc tac ttc cgc     1872
 Tyr Asn Val Thr Glu Lys Val Arg Arg Ile Met Glu Ser Tyr Phe Arg
     610                 615                 620

 ctg gat acg ccc ctc tac ttt tcc tac tct cat ctg gtg tgc cgc act     1920
 Leu Asp Thr Pro Leu Tyr Phe Ser Tyr Ser His Leu Val Cys Arg Thr
 625                 630                 635                 640

 gcc atc gaa gag gtc cag gca gag agg aag gat gat agt cat cca gtc     1968
 Ala Ile Glu Glu Val Gln Ala Glu Arg Lys Asp Asp Ser His Pro Val
                 645                 650                 655

 cac gtg gac aac tgc atc ctg aat gcc gag acc ctc gtg tgt gtc aaa     2016
 His Val Asp Asn Cys Ile Leu Asn Ala Glu Thr Leu Val Cys Val Lys
             660                 665                 670

 gag ccc cca gcc tac acc ttc cgc gac tac agc gcc atc ctt tac cta     2064
 Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu
         675                 680                 685

 aat ggg gac ttc gat ggc gga aac ttt tat ttc act gaa ctg gat gcc     2112
 Asn Gly Asp Phe Asp Gly Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala
     690                 695                 700

 aag acc gtg acg gca gag gtg cag cct cag tgt gga aga gcc gtg gga     2160
 Lys Thr Val Thr Ala Glu Val Gln Pro Gln Cys Gly Arg Ala Val Gly
 705                 710                 715                 720

 ttc tct tca ggc act gaa aac cca cat gga gtg aag gct gtc acc agg     2208
 Phe Ser Ser Gly Thr Glu Asn Pro His Gly Val Lys Ala Val Thr Arg
                 725                 730                 735

 ggg cag cgc tgt gcc atc gcc ctg tgg ttc acc ctg gac cct cga cac     2256
 Gly Gln Arg Cys Ala Ile Ala Leu Trp Phe Thr Leu Asp Pro Arg His
             740                 745                 750

 agc gag cgg gac agg gtg cag gca gat gac ctg gtg aag atg ctc ttc     2304
 Ser Glu Arg Asp Arg Val Gln Ala Asp Asp Leu Val Lys Met Leu Phe
         755                 760                 765

 agc cca gaa gag atg gac ctc tcc cag gag cag ccc ctg gat gcc cag     2352
 Ser Pro Glu Glu Met Asp Leu Ser Gln Glu Gln Pro Leu Asp Ala Gln
     770                 775                 780

 cag ggc ccc ccc gaa cct gca caa gag tct ctc tca ggc agt gaa tcg     2400
 Gln Gly Pro Pro Glu Pro Ala Gln Glu Ser Leu Ser Gly Ser Glu Ser
 785                 790                 795                 800

 aag ccc aag gat gag cta tga ca gcgtccaggt cagacggatg ggtgactaga     2453
 Lys Pro Lys Asp Glu Leu 
                 805

 cccatggaga ggaactcttc tgcactctga gctggccagc ccctcggggc tgcagagcag   2513

 tgagcctaca tctgccactc agccgagggg accctgctca cagccttcta catggtgcta   2573

 ctgctcttgg agtggacatg accagacacc gcaccccctg gatctggctg agggctcagg   2633

 acacaggccc agccaccccc aggggcctcc acaggccgct gcataacagc gatacagtac   2693

 ttaagtgtct gtgtagacaa ccaaagaata aatgattcat ggtttttttt aaaaaaaaaa   2753




      <210> 45
      <211> 1476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (633)..(1367)

      <400> 45
 cctggtacac tcaaacttta tttggttgcc tggatggggc caaaaaggag gacaagaagg     60

 gtgtcaaagg gtcagctcaa taggggtgat tcagggtgtg ctccatgatg gtcaaaagcg    120

 ccagccacgt ctccttggct gtggggatga tctgggaggc tggcagcagg aagccatagc    180

 gcccagtgtc ccggagctcg aaggtgaagg agtacttgat gccctggctg taggtccagt    240

 caatagtgct tccactggct tgataaattg ccttgatgat gctgccatag ttgaacttgg    300

 tcccgtagag agaggccagg gctgtcacag cagccttgga aagctgatcc agctcatcct    360

 ggtcagggac tggttctgtt ttgtagccat agggatacat gaggagctgg gagtagctgt    420

 ggatggagat gaaggccttg atgttcccat ggtccttcac aaagtctaca atggacttga    480

 cctccacttc ggaattggca aacttgccgt ggtaagtctc cgagcagggg ttactgctgg    540

 ctccggacaa cccaaagcca gcgtcccagt tcctgttggg gtccacgcca atacagaggg    600

 agcctgctgt gtgggaccga gtcttgcgcc ac  atg cga ttc gtg ctg tgc gtg     653
                                      Met Arg Phe Val Leu Cys Val
                                        1               5

 aag gca aag cca tca ggg ttg gtg acg atc tcc agg aag atc act caa      701
 Lys Ala Lys Pro Ser Gly Leu Val Thr Ile Ser Arg Lys Ile Thr Gln
          10                  15                  20

 gac tac ggg cag gat gca gct ttc acc gcc att ctc gac acc ttg gac      749
 Asp Tyr Gly Gln Asp Ala Ala Phe Thr Ala Ile Leu Asp Thr Leu Asp
      25                  30                  35

 atc ttc ctg gag atc gtc acc aac cct gat ggc ttt gcc ttc acg cac      797
 Ile Phe Leu Glu Ile Val Thr Asn Pro Asp Gly Phe Ala Phe Thr His
  40                  45                  50                  55

 agc acg aat cgc atg tgg cgc aag act cgg tcc cac aca gca ggc tcc      845
 Ser Thr Asn Arg Met Trp Arg Lys Thr Arg Ser His Thr Ala Gly Ser
                  60                  65                  70

 ctc tgt att ggc gtg gac ccc aac agg aac tgg gac gct ggc ttt ggg      893
 Leu Cys Ile Gly Val Asp Pro Asn Arg Asn Trp Asp Ala Gly Phe Gly
              75                  80                  85

 ttg tcc gga gcc agc agt aac ccc tgc tcg gag act tac cac ggc aag      941
 Leu Ser Gly Ala Ser Ser Asn Pro Cys Ser Glu Thr Tyr His Gly Lys
          90                  95                 100

 ttt gcc aat tcc gaa gtg gag gtc aag tcc att gta gac ttt gtg aag      989
 Phe Ala Asn Ser Glu Val Glu Val Lys Ser Ile Val Asp Phe Val Lys
     105                 110                 115

 gac cat ggg aac atc aag gcc ttc atc tcc atc cac agc tac tcc cag     1037
 Asp His Gly Asn Ile Lys Ala Phe Ile Ser Ile His Ser Tyr Ser Gln
 120                 125                 130                 135

 ctc ctc atg tat ccc tat ggc tac aaa aca gaa cca gtc cct gac cag     1085
 Leu Leu Met Tyr Pro Tyr Gly Tyr Lys Thr Glu Pro Val Pro Asp Gln
                 140                 145                 150

 gat gag ctg gat cag ctt tcc aag gct gct gtg aca gcc ctg gcc tct     1133
 Asp Glu Leu Asp Gln Leu Ser Lys Ala Ala Val Thr Ala Leu Ala Ser
             155                 160                 165

 ctc tac ggg acc aag ttc aac tat ggc agc atc atc aag gca att tat     1181
 Leu Tyr Gly Thr Lys Phe Asn Tyr Gly Ser Ile Ile Lys Ala Ile Tyr
         170                 175                 180

 caa gcc agt gga agc act att gac tgg acc tac agc cag ggc atc aag     1229
 Gln Ala Ser Gly Ser Thr Ile Asp Trp Thr Tyr Ser Gln Gly Ile Lys
     185                 190                 195

 tac tcc ttc acc ttc gag ctc cgg gac act ggg cgc tat ggc ttc ctg     1277
 Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr Gly Arg Tyr Gly Phe Leu
 200                 205                 210                 215

 ctg cca gcc tcc cag atc atc ccc aca gcc aag gag acg tgg ctg gcg     1325
 Leu Pro Ala Ser Gln Ile Ile Pro Thr Ala Lys Glu Thr Trp Leu Ala
                 220                 225                 230

 ctt ctg acc atc atg gag cac acc ctg aat cac ccc tac tga gctgacc     1374
 Leu Leu Thr Ile Met Glu His Thr Leu Asn His Pro Tyr 
             235                 240

 ctttgacacc cttcttgtcc tcctctctgg ccccatccag gcaaccaaat aaagtttgag   1434

 tgtaccagga acagaatcct ggggcttgca aaaaaaaaaa aa                      1476




      <210> 46
      <211> 1769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(1753)

      <400> 46
 ccagatcgcc gcgcgagggt ggtgggcatc gaggtcccag cagcggacga gggaggtgcc     60

 gccgtcgccc aggatgggct gggaatgaag cgatgtagcc ttttaagaga tttgctctga    120

 cccatctgaa gtccat    atg gct ctg tat gat gaa gac ctc ctg aaa aat     169
                      Met Ala Leu Tyr Asp Glu Asp Leu Leu Lys Asn
                        1               5                  10

 cct ttc tat ctg gct ctg caa aag tgc cgc cct gac ttg tgc agc aaa      217
 Pro Phe Tyr Leu Ala Leu Gln Lys Cys Arg Pro Asp Leu Cys Ser Lys
              15                  20                  25

 gtg gcc caa atc cat ggc att gtc tta gta ccc tgc aaa gga agc ctg      265
 Val Ala Gln Ile His Gly Ile Val Leu Val Pro Cys Lys Gly Ser Leu
          30                  35                  40

 tcg agc agc atc cag tct act tgt cag ttt gag tcc tac att ttg ata      313
 Ser Ser Ser Ile Gln Ser Thr Cys Gln Phe Glu Ser Tyr Ile Leu Ile
      45                  50                  55

 cct gtg gaa gag cat ttt cag acc tta aat gga aag gat gtc ttt att      361
 Pro Val Glu Glu His Phe Gln Thr Leu Asn Gly Lys Asp Val Phe Ile
  60                  65                  70                  75

 caa ggg aac agg att aaa tta gga gct ggt ttt gcc tgt ctt ctc tca      409
 Gln Gly Asn Arg Ile Lys Leu Gly Ala Gly Phe Ala Cys Leu Leu Ser
                  80                  85                  90

 gtg ccc att ctc ttt gaa gaa act ttc tac aat gaa aaa gaa gag agt      457
 Val Pro Ile Leu Phe Glu Glu Thr Phe Tyr Asn Glu Lys Glu Glu Ser
              95                 100                 105

 ttc agc atc ctg tgt ata gcc cat cct ttg gaa aag aga gag agt tca      505
 Phe Ser Ile Leu Cys Ile Ala His Pro Leu Glu Lys Arg Glu Ser Ser
         110                 115                 120

 gaa gag cct ttg gca ccc tca gat ccc ttt tcc ctg aaa acc att gaa      553
 Glu Glu Pro Leu Ala Pro Ser Asp Pro Phe Ser Leu Lys Thr Ile Glu
     125                 130                 135

 gat gtg aga gag ttc ttg gga aga cac tcc gag cga ttt gac agg aac      601
 Asp Val Arg Glu Phe Leu Gly Arg His Ser Glu Arg Phe Asp Arg Asn
 140                 145                 150                 155

 atc gcc tct ttc cat cga aca ttc cga gaa tgc gag aga aag agc ctc      649
 Ile Ala Ser Phe His Arg Thr Phe Arg Glu Cys Glu Arg Lys Ser Leu
                 160                 165                 170

 cgt cac cac ata gac tca gcg aat gct ctc tac acc aaa tgc ctc cag      697
 Arg His His Ile Asp Ser Ala Asn Ala Leu Tyr Thr Lys Cys Leu Gln
             175                 180                 185

 cag ctt ctg agg gac tct cac ctg aaa atg ctc gcc aag cag gag gcc      745
 Gln Leu Leu Arg Asp Ser His Leu Lys Met Leu Ala Lys Gln Glu Ala
         190                 195                 200

 cag atg aac ctg atg aag cag gca gtg gag ata tac gtc cat cat gaa      793
 Gln Met Asn Leu Met Lys Gln Ala Val Glu Ile Tyr Val His His Glu
     205                 210                 215

 att tac aac ctg atc ttt aaa tac gtg ggg acc atg gag gca agt gag      841
 Ile Tyr Asn Leu Ile Phe Lys Tyr Val Gly Thr Met Glu Ala Ser Glu
 220                 225                 230                 235

 gat gcg gcc ttt aac aaa atc aca aga agc ctt caa gat ctt cag cag      889
 Asp Ala Ala Phe Asn Lys Ile Thr Arg Ser Leu Gln Asp Leu Gln Gln
                 240                 245                 250

 aaa gat att ggt gtg aaa ccg gag ttc agc ttt aac ata cct cgt gcc      937
 Lys Asp Ile Gly Val Lys Pro Glu Phe Ser Phe Asn Ile Pro Arg Ala
             255                 260                 265

 aaa aga gag ctg gct cag ctg aac aaa tgc acc tcc cca cag cag aag      985
 Lys Arg Glu Leu Ala Gln Leu Asn Lys Cys Thr Ser Pro Gln Gln Lys
         270                 275                 280

 ctt gtc tgc ttg cga aaa gtg gtg cag ctc att aca cag tct cca agc     1033
 Leu Val Cys Leu Arg Lys Val Val Gln Leu Ile Thr Gln Ser Pro Ser
     285                 290                 295

 cag aga gtg aac ctg gag acc atg tgt gct gat gat ctg cta tca gtc     1081
 Gln Arg Val Asn Leu Glu Thr Met Cys Ala Asp Asp Leu Leu Ser Val
 300                 305                 310                 315

 ctg tta tac ttg ctt gtg aaa acg gag atc cct aat tgg atg gca aat     1129
 Leu Leu Tyr Leu Leu Val Lys Thr Glu Ile Pro Asn Trp Met Ala Asn
                 320                 325                 330

 ttg agt tac atc aaa aac ttc agg ttt agc agc ttg gca aag gat gaa     1177
 Leu Ser Tyr Ile Lys Asn Phe Arg Phe Ser Ser Leu Ala Lys Asp Glu
             335                 340                 345

 ctg gga tac tgc ctg acc tca ttc gaa gct gcc att gaa tat att cgg     1225
 Leu Gly Tyr Cys Leu Thr Ser Phe Glu Ala Ala Ile Glu Tyr Ile Arg
         350                 355                 360

 caa gga agc ctc tct gct aaa ccc cct gag tct gag gga ttt gga gac     1273
 Gln Gly Ser Leu Ser Ala Lys Pro Pro Glu Ser Glu Gly Phe Gly Asp
     365                 370                 375

 agg ctg ttc ctt aag cag aga atg agc tta ctc tct cag atg act tcg     1321
 Arg Leu Phe Leu Lys Gln Arg Met Ser Leu Leu Ser Gln Met Thr Ser
 380                 385                 390                 395

 tct ccc acc gac tgc ctg ttt aag cac att gca tca ggt aac cag aaa     1369
 Ser Pro Thr Asp Cys Leu Phe Lys His Ile Ala Ser Gly Asn Gln Lys
                 400                 405                 410

 gaa gtg gag aga ctt ctg agc caa gag gac cat gat aaa gat acc gtc     1417
 Glu Val Glu Arg Leu Leu Ser Gln Glu Asp His Asp Lys Asp Thr Val
             415                 420                 425

 caa aag atg tgt cac cct ctc tgc ttc tgc gat gac tgt gag aaa ctc     1465
 Gln Lys Met Cys His Pro Leu Cys Phe Cys Asp Asp Cys Glu Lys Leu
         430                 435                 440

 gtc tct ggg agg ttg aat gat ccc tca gtt gtc act cca ttc tcc aga     1513
 Val Ser Gly Arg Leu Asn Asp Pro Ser Val Val Thr Pro Phe Ser Arg
     445                 450                 455

 gac gac agg ggg cac acc cct ctc cat gtg gct gct gtc tgt ggg cag     1561
 Asp Asp Arg Gly His Thr Pro Leu His Val Ala Ala Val Cys Gly Gln
 460                 465                 470                 475

 gca tcc ctc atc gac ctc ctg gtt tcc aag ggc gcc atg gta aat gcc     1609
 Ala Ser Leu Ile Asp Leu Leu Val Ser Lys Gly Ala Met Val Asn Ala
                 480                 485                 490

 aca gac tac cat gga gcc act ccg ctc cac ctg gcc tgt cag aag ggc     1657
 Thr Asp Tyr His Gly Ala Thr Pro Leu His Leu Ala Cys Gln Lys Gly
             495                 500                 505

 tac cag agc gtg acg ctg ctg ctg ctg cac tac aag gcc agc gcg gaa     1705
 Tyr Gln Ser Val Thr Leu Leu Leu Leu His Tyr Lys Ala Ser Ala Glu
         510                 515                 520

 gtg cag gac aac aat ggg aat acg cca cat gta ttg cgg ccg ctc tag     1753
 Val Gln Asp Asn Asn Gly Asn Thr Pro His Val Leu Arg Pro Leu 
     525                 530                 535

 aggatcccag ctaacg                                                   1769




      <210> 47
      <211> 1501
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (749)..(1447)

      <400> 47
 tttcgtctgc ccaaggcctc catggctgag cctggaggct cttggaacag gctccgcgcc     60

 caagctggca gacatgggtg ctctctggag ccgtcagaga gggcagagag ctcgtggttt    120

 atggtgtaaa ggctgggagc ttggaggggg tcgtgtgtgg ggctggactc tgaggcggcc    180

 agaggcctag gaacgttatc ctgggcacac cgtgcgtggt gtgcagtctg agtcatgctc    240

 cctgggtagg gcatccagct cccagcctgg gagtgctgag agccaaatcc accgtagagc    300

 aggggtgaga gtcagggtcc cacctcctct atctgccggc aatccagtgg tgacctaggg    360

 taaaagcttg agagtcccat acacacggtc atcccacgac atacctcaca ggccaggcag    420

 ggacacacag cccccttccc tccctcccag gtaccgtcat agctgctagt gtgactgaag    480

 gcagtgtccc tggccccagc tgaagcaccg tagccagcca gcgggctcac gcaccttggc    540

 ctgttgctcc tagggtcact tgtgccattc agccaagggg acgaccgtgc ctgctggccc    600

 agctgagctc cgcccagtga gcccaccccc cattctcctg ccactgactc tcgctcttct    660

 gcttttccca gcaggaaggg cccagcctca cctacgagac ctgcagcccc ccgaccagct    720

 gaggctcccc tcttagactt ataagtct   atg gcc act ggc atc cgg ctg cct     772
                                  Met Ala Thr Gly Ile Arg Leu Pro
                                    1               5

 gcc ctc cct gcc tcc ccc agg gtc cct tca gag ggt cct ggg ttt tct      820
 Ala Leu Pro Ala Ser Pro Arg Val Pro Ser Glu Gly Pro Gly Phe Ser
      10                  15                  20

 gaa cac cca gag ggg cct ccg gcg ctc cct cca gcc atc cct ttt agt      868
 Glu His Pro Glu Gly Pro Pro Ala Leu Pro Pro Ala Ile Pro Phe Ser
  25                  30                  35                  40

 ttc acc ctc ctg gtt caa gca gtg ttc ttt ctc tat cag gcc tgg tgg      916
 Phe Thr Leu Leu Val Gln Ala Val Phe Phe Leu Tyr Gln Ala Trp Trp
                  45                  50                  55

 ctg ttg cat ggg gct ccc caa ggc aag ggg tgg ccc cag gcc agt ggg      964
 Leu Leu His Gly Ala Pro Gln Gly Lys Gly Trp Pro Gln Ala Ser Gly
              60                  65                  70

 ttg gaa gac agg gtg acc aga gaa gag gga agc ccg agg ggg ccg agc     1012
 Leu Glu Asp Arg Val Thr Arg Glu Glu Gly Ser Pro Arg Gly Pro Ser
          75                  80                  85

 atc agc ctg aat tgc ggg tgc cct gcc tgg gtg ccg tgt gag agg cca     1060
 Ile Ser Leu Asn Cys Gly Cys Pro Ala Trp Val Pro Cys Glu Arg Pro
      90                  95                 100

 gcg tgt gtg ggg tgg gga ggg ccg cca cag ccc cca ggc gct atc tgt     1108
 Ala Cys Val Gly Trp Gly Gly Pro Pro Gln Pro Pro Gly Ala Ile Cys
 105                 110                 115                 120

 gaa gct acg gct cct ccc tcc atc ttc ctc ccc ttt ccc ttc cag ccc     1156
 Glu Ala Thr Ala Pro Pro Ser Ile Phe Leu Pro Phe Pro Phe Gln Pro
                 125                 130                 135

 ctt ttc cag gaa cct tgc cac acc cac acc tgc agc ctc ccc tcc ccg     1204
 Leu Phe Gln Glu Pro Cys His Thr His Thr Cys Ser Leu Pro Ser Pro
             140                 145                 150

 gcc ctc cca cca ctg ctg cgg cgc ggc cgg ccc cgg ccg tgt gct gcg     1252
 Ala Leu Pro Pro Leu Leu Arg Arg Gly Arg Pro Arg Pro Cys Ala Ala
         155                 160                 165

 ctt gcc tta cca gct ctc tcc tcg ctt ttc tct ccc gtt ttc tct ctg     1300
 Leu Ala Leu Pro Ala Leu Ser Ser Leu Phe Ser Pro Val Phe Ser Leu
     170                 175                 180

 ctt tct ctc caa ctg cca gcc gat cgg gtc agg caa gtc cat ccc gtc     1348
 Leu Ser Leu Gln Leu Pro Ala Asp Arg Val Arg Gln Val His Pro Val
 185                 190                 195                 200

 ctg aga gcc cca ggc ccc cct tcg acc tct aaa cag atc cct cct ctt     1396
 Leu Arg Ala Pro Gly Pro Pro Ser Thr Ser Lys Gln Ile Pro Pro Leu
                 205                 210                 215

 ctc gga gac ctc cct ttc caa gcc tgc ctg gac ggc tgt tct gtg act     1444
 Leu Gly Asp Leu Pro Phe Gln Ala Cys Leu Asp Gly Cys Ser Val Thr
             220                 225                 230

 tga cagt ggctccccca gccccaaagc cagccccctt catctgtgac ttaatctgtt     1501
 






      <210> 48
      <211> 659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (250)..(567)

      <400> 48
 tcccgtgtcg acgatttcgt ggctgccact gtggggcttc tgccggccgg tagtccctgg     60

 cgctgctgac ccagcatcgg cttttctacg tcttgaacct ggattcgcct aggggttggg    120

 aagggctgtg gacggcgttg ggggaggcct gacgagatta ataaagaact cttcagaatt    180

 cctggtgttt catcatatat acgactaaga tatcaactct tctagcttgc tgtctctgga    240

 ccaaaaaaa    atg acg tct att atc aaa tta act acc ctt tct ggg gtc     288
              Met Thr Ser Ile Ile Lys Leu Thr Thr Leu Ser Gly Val
                1               5                  10

 caa gaa gaa tct gcc ctt tgc tat ctt ctc caa gtt gat gag ttt aga      336
 Gln Glu Glu Ser Ala Leu Cys Tyr Leu Leu Gln Val Asp Glu Phe Arg
      15                  20                  25

 ttt tta ttg gac tgt ggc tgg gat gag cac ttt tct atg gat att att      384
 Phe Leu Leu Asp Cys Gly Trp Asp Glu His Phe Ser Met Asp Ile Ile
  30                  35                  40                  45

 gat tcc ctg agg aag cat gtt cac cag att gat gca gtg ctg ttg tct      432
 Asp Ser Leu Arg Lys His Val His Gln Ile Asp Ala Val Leu Leu Ser
                  50                  55                  60

 cac cct gat cct ctc cac ctt ggt gcc ctc ccg tat gct gtc gga aag      480
 His Pro Asp Pro Leu His Leu Gly Ala Leu Pro Tyr Ala Val Gly Lys
              65                  70                  75

 ttg ggt ctg aac tgt gct atc tat gca act att cct gtt tat aaa atg      528
 Leu Gly Leu Asn Cys Ala Ile Tyr Ala Thr Ile Pro Val Tyr Lys Met
          80                  85                  90

 gga cag atg ttc atg tat gat ctt tat cag gta att taa gcaattaaaa       577
 Gly Gln Met Phe Met Tyr Asp Leu Tyr Gln Val Ile 
      95                 100                 105

 aaattttgtt agcactcctt cagtgattgt ttttcacctt tatttgtgtt attcttttag    637

 tctcgacaca atacagaaga tg                                             659




      <210> 49
      <211> 1486
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(1188)

      <400> 49
 ggaattcccg ggtcgacgat ttcgtgcgac ggctgctgtg tctcctggaa agggattccc     60

 gaaaggtttt attccaaaag gagaggttgg aagacatagc tcatctcctg ctgtgtatca    120

 gccaagaagg tgtgaggtgg tgttccttgg ggatccgctt gcatctactt ggggtggttt    180

 tgaaac   atg aat ctt tcg ctc gtc ctg gct gcc ttt tgc ttg gga ata     228
          Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile
            1               5                  10

 gcc tcc gct gtt cca aaa ttt gac caa aat ttg gat aca aag tgg tac      276
 Ala Ser Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr
  15                  20                  25                  30

 cag tgg aag gca aca cac aga aga tta tat ggc gcg aat gaa gaa gga      324
 Gln Trp Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly
                  35                  40                  45

 tgg agg aga gca gtg tgg gaa aag aat atg aaa atg att gaa ctg cac      372
 Trp Arg Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His
              50                  55                  60

 aat ggg gaa tac agc caa ggg aaa cac agc ttc aca atg gcc atg aat      420
 Asn Gly Glu Tyr Ser Gln Gly Lys His Ser Phe Thr Met Ala Met Asn
          65                  70                  75

 gcc ttt gga gac atg acc aat gaa gaa ttc agg cag gtg atg aat ggt      468
 Ala Phe Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly
      80                  85                  90

 ttt caa tac cag aag cac agg aag ggg aaa cag ttc cag gaa cgc ctg      516
 Phe Gln Tyr Gln Lys His Arg Lys Gly Lys Gln Phe Gln Glu Arg Leu
  95                 100                 105                 110

 ctt ctt gag atc ccc aca tct gtg gac tgg aga gag aaa ggc tac atg      564
 Leu Leu Glu Ile Pro Thr Ser Val Asp Trp Arg Glu Lys Gly Tyr Met
                 115                 120                 125

 act cct gtg aag gat cag ggt cag tgt ggc tct tgt tgg gct ttt agt      612
 Thr Pro Val Lys Asp Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser
             130                 135                 140

 gca act ggt gct ctg gaa ggg cag atg ttc tgg aaa aca ggc aaa ctt      660
 Ala Thr Gly Ala Leu Glu Gly Gln Met Phe Trp Lys Thr Gly Lys Leu
         145                 150                 155

 atc tca ctg aat gag cag aat ctg gta gac tgc tct ggg cct caa ggc      708
 Ile Ser Leu Asn Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly
     160                 165                 170

 aat gag ggc tgc aat ggt gac ttc atg gat aat ccc ttc cgg tat gtt      756
 Asn Glu Gly Cys Asn Gly Asp Phe Met Asp Asn Pro Phe Arg Tyr Val
 175                 180                 185                 190

 cag gag aac gga ggc ctg gac tct gag gaa tcc tat cca tat gag gca      804
 Gln Glu Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala
                 195                 200                 205

 aca gaa gaa tcc tgt aag tac aat ccc aag tat tct gtt gct aat gac      852
 Thr Glu Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp
             210                 215                 220

 acc ggc ttt gtg gac atc cct aag cag gag aag gcc ctg atg aag gca      900
 Thr Gly Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala
         225                 230                 235

 gtt gca act gtg ggg ccc att tct gtt gct att gat gca ggt cat gag      948
 Val Ala Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu
     240                 245                 250

 tcc ttc ctg ttc tat aaa gaa ggc att tat ttt gag cca gac tgt agc      996
 Ser Phe Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser
 255                 260                 265                 270

 agt gaa gac atg gat cat ggt gtg ctg gtg gtt ggc tac gga ttt gaa     1044
 Ser Glu Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu
                 275                 280                 285

 agc aca gaa tca gat aac aat aaa tat tgg ctg gtg aag aac agc tgg     1092
 Ser Thr Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp
             290                 295                 300

 ggt gaa gaa tgg ggc atg ggt ggc tac gta aag atg gcc aaa gac cgg     1140
 Gly Glu Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg
         305                 310                 315

 aga aac cat tgt gga att gcc tca gca gcc agc tac ccc act gtg tga     1188
 Arg Asn His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
     320                 325                 330

 gctggtggac ggtgatgagg aaggacttga ctggggatgg cgcatgcatg ggaggaattc   1248

 atcttcagtc taccagcccc cgctgtgtcg gatacacact cgaatcattg aagatccgag   1308

 tgtgatttga attctgtgat attttcacac tggtaaatgt tacctctatt ttaattactg   1368

 ctataaatag gtttatatta ttgattcact tactgacttt gcattttcgt ttttaaaagg   1428

 atgtataaat ttttacctgt ttaaataaaa tttaatttca aatgtaaaaa aaaaaaaa     1486




      <210> 50
      <211> 799
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(749)

      <400> 50
 tgcacgaggc gggaatgggc cccaggctct cgtcctgagc ggtcggctgg acgtgggggc     60

 gccactgacc accgtggaga agcccggggg aggggaggtg ctttctggct gcacactgac    120

 ct   atg ttg ggg tgc cag ggc agg atg tac acg ctg ctg tcg ggc ttg     167
      Met Leu Gly Cys Gln Gly Arg Met Tyr Thr Leu Leu Ser Gly Leu
        1               5                  10                  15

 tac aag tac atg ttt cag aag gac gag tac tgc atc ctg atc ctg ggc      215
 Tyr Lys Tyr Met Phe Gln Lys Asp Glu Tyr Cys Ile Leu Ile Leu Gly
                  20                  25                  30

 ctg gac aat gct ggg aag acg acc ttc ctg gag cag tcg aaa acc cga      263
 Leu Asp Asn Ala Gly Lys Thr Thr Phe Leu Glu Gln Ser Lys Thr Arg
              35                  40                  45

 ttt aac aag aac tac aag ggg atg agt cta tcc aaa atc acc acc acc      311
 Phe Asn Lys Asn Tyr Lys Gly Met Ser Leu Ser Lys Ile Thr Thr Thr
          50                  55                  60

 gtg ggc cta aac atc ggc act gtg gat gtg gga aag gct cgg ctc atg      359
 Val Gly Leu Asn Ile Gly Thr Val Asp Val Gly Lys Ala Arg Leu Met
      65                  70                  75

 ttc tgg gac tta gga ggg cag gaa gag ctg cag tct ttg tgg gac aag      407
 Phe Trp Asp Leu Gly Gly Gln Glu Glu Leu Gln Ser Leu Trp Asp Lys
  80                  85                  90                  95

 tat tat gcg gag tgt cac ggc gtc atc tac gtc att gac tcc acc gac      455
 Tyr Tyr Ala Glu Cys His Gly Val Ile Tyr Val Ile Asp Ser Thr Asp
                 100                 105                 110

 gag gag agg ctg gct gag tcc aag cag gcg ttt gag aag gtg gtg acc      503
 Glu Glu Arg Leu Ala Glu Ser Lys Gln Ala Phe Glu Lys Val Val Thr
             115                 120                 125

 agc gag gcg ctg tgc ggt gtc ccc gtc ttg gtg ctg gcc aac aag cag      551
 Ser Glu Ala Leu Cys Gly Val Pro Val Leu Val Leu Ala Asn Lys Gln
         130                 135                 140

 gat gtg gag acg tgc ctc tca atc cct gac atc aag acg gcc ttc agc      599
 Asp Val Glu Thr Cys Leu Ser Ile Pro Asp Ile Lys Thr Ala Phe Ser
     145                 150                 155

 gac tgc acc agc aag atc ggc agg cga gat tgc ctg acc cag gcc tgc      647
 Asp Cys Thr Ser Lys Ile Gly Arg Arg Asp Cys Leu Thr Gln Ala Cys
 160                 165                 170                 175

 tcg gcc ctc aca ggc aaa ggg gtg cgc gag ggc atc gag tgg atg gtg      695
 Ser Ala Leu Thr Gly Lys Gly Val Arg Glu Gly Ile Glu Trp Met Val
                 180                 185                 190

 aag tgt gtc gtg cgg aat gtg cac cgg ccg ccg cgg cag agg gac atc      743
 Lys Cys Val Val Arg Asn Val His Arg Pro Pro Arg Gln Arg Asp Ile
             195                 200                 205

 acg tag gcgcagcccg cgcttgcccg tccgggacgg ctggtcccct ggtgctggag       799
 Thr 






      <210> 51
      <211> 1464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(855)

      <400> 51
 ctttgttcca agtacagccc cctaggactt ttgaaatgca gtctgccaca tgggtgagaa     60

 ggcatcaggg cctggtaaca ggcagtggag tatcagcagg tgggaaataa gttctctagt    120

 gatggtaggg ttggggaatg ctcaagaaaa ttgctaggct gagaa    atg cta tca     174
                                                      Met Leu Ser
                                                        1

 gtg gat att acc agc agg tac cgt gca ccc agt acc tat ctt ctt aac      222
 Val Asp Ile Thr Ser Arg Tyr Arg Ala Pro Ser Thr Tyr Leu Leu Asn
       5                  10                  15

 tcc ctg aaa gag ggg ctg gaa ggc ctc cat ggt gaa tct tgc tct tct      270
 Ser Leu Lys Glu Gly Leu Glu Gly Leu His Gly Glu Ser Cys Ser Ser
  20                  25                  30                  35

 ttt ctc ctg ggg ccc tca gtg gcc atg aat atg cag act gca ggg ctt      318
 Phe Leu Leu Gly Pro Ser Val Ala Met Asn Met Gln Thr Ala Gly Leu
                  40                  45                  50

 gaa atg gac atc tgt gat ggg cat ttc cgc cag aat ggc ggc tgt ggc      366
 Glu Met Asp Ile Cys Asp Gly His Phe Arg Gln Asn Gly Gly Cys Gly
              55                  60                  65

 tat gtg ctg aag cca gac ttc ctg cgt gat atc cag agt tct ttc cac      414
 Tyr Val Leu Lys Pro Asp Phe Leu Arg Asp Ile Gln Ser Ser Phe His
          70                  75                  80

 cct gag aag ccc atc agc cct ttc aaa gcc cag act ctc tta atc cag      462
 Pro Glu Lys Pro Ile Ser Pro Phe Lys Ala Gln Thr Leu Leu Ile Gln
      85                  90                  95

 gtg atc agc ggt cag caa ctc ccc aaa gtg gac aag acc aaa gag ggg      510
 Val Ile Ser Gly Gln Gln Leu Pro Lys Val Asp Lys Thr Lys Glu Gly
 100                 105                 110                 115

 tcc att gtg gat cca ctg gtg aaa gtg cag atc ttt ggc gtt cgt cta      558
 Ser Ile Val Asp Pro Leu Val Lys Val Gln Ile Phe Gly Val Arg Leu
                 120                 125                 130

 gac aca gca cgg cag gag acc aac tat gtg gag aac aat ggt ttt aat      606
 Asp Thr Ala Arg Gln Glu Thr Asn Tyr Val Glu Asn Asn Gly Phe Asn
             135                 140                 145

 cca tac tgg ggg cag aca cta tgt ttc cgg gtg ctg gtg cct gaa ctt      654
 Pro Tyr Trp Gly Gln Thr Leu Cys Phe Arg Val Leu Val Pro Glu Leu
         150                 155                 160

 gcc atg ctg cgt ttt gtg gta atg gat tat gac tgg aaa tcc cga aat      702
 Ala Met Leu Arg Phe Val Val Met Asp Tyr Asp Trp Lys Ser Arg Asn
     165                 170                 175

 gac ttt att ggt cag tac acc ctg cct tgg acc tgc atg caa caa ggt      750
 Asp Phe Ile Gly Gln Tyr Thr Leu Pro Trp Thr Cys Met Gln Gln Gly
 180                 185                 190                 195

 tac cgc cac att cac ctg ctg tcc aaa gat ggc atc agc ctc cgc cca      798
 Tyr Arg His Ile His Leu Leu Ser Lys Asp Gly Ile Ser Leu Arg Pro
                 200                 205                 210

 gct tcc atc ttt gtg tat atc tgc atc cag gaa ggc ctg gag ggg gat      846
 Ala Ser Ile Phe Val Tyr Ile Cys Ile Gln Glu Gly Leu Glu Gly Asp
             215                 220                 225

 gag tcc tga ggtgggc atttcacggg aagggttggt gtgctggctt tagacgggga      902
 Glu Ser 


 gaaacatctg gaaggatgct cgagagaaca aatggaggtg gtgaaaatca agctttggat    962

 tgtgcattcc taggcacaaa attacctcat tcttcctaac aagcaatctg ggacctgatt   1022

 ttccaccttt tttctctttt cttcccttcc tttgttttca taagcctttg gtatctttcc   1082

 tgcccttttc ctttgtgtac tctatactgg agttcccttc ttcctcttgc tgtaggctca   1142

 atcccatacc gacatctaca actaatcttt cccatcaact ctgtgtgaag gcaggttgca   1202

 actagaaatt cagaggggct tggaatagag aaacctaaag aagcatcatc ccctccatcc   1262

 ccaacttcct caaagcccaa agccaaggga aggataaatc aaggctcaag gcttccccag   1322

 caaagattag ggaaagagac ttgaccccag gactgtacta cgactcttaa gagaacactg   1382

 cacagcactc aaagtccccc actggactgc ttcctcctta gccccactgg tataaataca   1442

 tctctctcca atttggcttc aa                                            1464




      <210> 52
      <211> 1232
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (344)..(1015)

      <400> 52
 gttgtggaat tcaggggaag taacttgaag gtaggaaccc agcttgtgag ccccctagcc     60

 tctgggctgc tctgcatgtg ccccctcttg ctggatcatc tggtagcagc cctgtgccct    120

 gagggtgatg ctctgaccta tgcagccccc ctccctgtcc tgagaaggct tccagctggg    180

 ccttggagga cagggtccac ccctacctcc tggtctcctt cctcagcttg gaagccccgg    240

 agcctgccct gctgggaatc ggggaagcac tgcttacctg tctcctgctc ccttttcagg    300

 tgcctgtggc aggcagcacc ttgagccaac aggaaccatt gac  atg cga ggc cca     355
                                                  Met Arg Gly Pro
                                                    1

 ggg cag gca gac tgt gca gtg gcc att ggg cgg ccc ctc ggg gag gtg      403
 Gly Gln Ala Asp Cys Ala Val Ala Ile Gly Arg Pro Leu Gly Glu Val
   5                  10                  15                  20

 gtg acc ctc cgc gtc ctt gag agt tct ctc aac tgc agt gcg ggg gac      451
 Val Thr Leu Arg Val Leu Glu Ser Ser Leu Asn Cys Ser Ala Gly Asp
                  25                  30                  35

 atg ttg ctg ctt tgg ggc cgg ctc acc tgg agg aag atg tgc agg aag      499
 Met Leu Leu Leu Trp Gly Arg Leu Thr Trp Arg Lys Met Cys Arg Lys
              40                  45                  50

 ctg ttg gac atg act ttc agc tcc aag acc aac acg ctg gtg gtg agg      547
 Leu Leu Asp Met Thr Phe Ser Ser Lys Thr Asn Thr Leu Val Val Arg
          55                  60                  65

 cag cgc tgc ggg cgg cca gga ggt ggg gtg ctg ctg cgg tat ggg agc      595
 Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu Arg Tyr Gly Ser
      70                  75                  80

 cag ctt gct cct gaa acc ttc tac aga gaa tgt gac atg cag ctc ttt      643
 Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu Cys Asp Met Gln Leu Phe
  85                  90                  95                 100

 ggg ccc tgg ggt gaa atc gtg agc ccc tcg ctg agt cca gcc acg agt      691
 Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu Ser Pro Ala Thr Ser
                 105                 110                 115

 aat gca ggg ggc tgc cgg ctc ttc att aat gtg gct ccg cac gca cgg      739
 Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn Val Ala Pro His Ala Arg
             120                 125                 130

 att gcc atc cat gcc ctg gcc acc aac atg ggc gct ggg acc gag gga      787
 Ile Ala Ile His Ala Leu Ala Thr Asn Met Gly Ala Gly Thr Glu Gly
         135                 140                 145

 gcc aat gcc agc tac atc ttg atc cgg gac acc cac agc ttg agg acc      835
 Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp Thr His Ser Leu Arg Thr
     150                 155                 160

 aca gcg ttc cat ggg cag cag gtg ctc tac tgg gag tca gag agc agc      883
 Thr Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu Ser Glu Ser Ser
 165                 170                 175                 180

 cag gct gag atg gag ttc agc gag ggc ttc ctg aag gct cag gcc agc      931
 Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys Ala Gln Ala Ser
                 185                 190                 195

 ctg cgg ggc cag tac tgg aca ctc caa tca tgg gta ccg gag atg cag      979
 Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser Trp Val Pro Glu Met Gln
             200                 205                 210

 gac cct cag tcc tgg aag gga aag gaa gga acc tga gggt cattgaacat     1029
 Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Thr 
         215                 220

 ttgttccgtg tctggccagc cctggagggt tgacccctgg tctcagtgct ttccaattcg   1089

 aactttttcc aatcttaggt atctacttta gagtcttctc caatgtccaa aaggctaggg   1149

 ggttggaggt ggggactctg gaaaagcagc ccccatttcc tcgggtacca ataaataaaa   1209

 catgcaggct gaaaaaaaaa aaa                                           1232




      <210> 53
      <211> 934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (375)..(596)

      <220>
      <221> misc_feature
      <222> (1)...(934)
      <223> n = a,t,c or g

      <400> 53
 cgcctgcggc accggtccgg aattcccggg tcgacgattt cgtgctaaga ccctgcttct     60

 ccctggctcg tcctctactc gggcactacc cctggcctga ccctggtgag cctccacacg    120

 cacgggcaat gccttgggtc ctagaccgtg ggctgggagc cacataaagg tcttgggtac    180

 tcttaggagt aggtgcccgg gggagcacgc ccaggacata tcaggttccc tcaccaagct    240

 tagccccctc tgccctctgt tgagtctcct gagtcccttt ggagtccctc tcttgctccc    300

 atgcagacaa ctggaagcag gagctgacaa aattcatcag ccccgaccag ctgcctgtgg    360

 agtttggggg gacc  atg act gac ccc gat ggc aac ccc aag tgc ctg acc     410
                  Met Thr Asp Pro Asp Gly Asn Pro Lys Cys Leu Thr
                    1               5                  10

 aag atc aac tac ggg ggt gag gtg ccc aag agc tac tac ctg tgc aag      458
 Lys Ile Asn Tyr Gly Gly Glu Val Pro Lys Ser Tyr Tyr Leu Cys Lys
          15                  20                  25

 cag gtg agg ctg cag tat gag cac acg agg tcc gtg ggc cgc ggc tcc      506
 Gln Val Arg Leu Gln Tyr Glu His Thr Arg Ser Val Gly Arg Gly Ser
      30                  35                  40

 tcc ctg cag gtg gag aac gag atc ctg ttc ccg ggc tgt gtg ctc aga      554
 Ser Leu Gln Val Glu Asn Glu Ile Leu Phe Pro Gly Cys Val Leu Arg
  45                  50                  55                  60

 tgt cct gag gtt tta caa cac cta cag cct ggt tca ttc taa acgcatc      603
 Cys Pro Glu Val Leu Gln His Leu Gln Pro Gly Ser Phe 
                  65                  70

 agctacaccg tggaggtact gctcccagac caaaccttca tggagaagat ggagaaattc    663

 taggtgaacc tcatggtccc cacaccctcc tctttgatct ctgaatccac aatgagttca    723

 cagccttccc tggccagacc ctgttcaacc tctcaggaac agggattcta caacagcagg    783

 tcacagccta tgcatcacag ctggcccact cctcaagaac ggctgggaca gtgtcctagt    843

 ggtggcccga tggtcacagc annagcacac agacactcca tccccactat gacctgctgt    903

 gacctcaagc tcagcaaaac cccaggcttt g                                   934




      <210> 54
      <211> 700
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(656)

      <400> 54
 taccggtccg gaattcccgg gtcgacgatt tcgtggcttg ggtaaaa  atg gct gaa      56
                                                      Met Ala Glu
                                                        1

 tat tta gct tcg ata ttc ggg act gag aag gac aag gtt aac tgc tct      104
 Tyr Leu Ala Ser Ile Phe Gly Thr Glu Lys Asp Lys Val Asn Cys Ser
       5                  10                  15

 ttt tac ttt aag atc ggg gtc tgc cgg cac ggg gac cgg tgc tcc cgg      152
 Phe Tyr Phe Lys Ile Gly Val Cys Arg His Gly Asp Arg Cys Ser Arg
  20                  25                  30                  35

 ctt cac aac aag ccg aca ttc agc cag gag gtg ttc aca gaa ctg cag      200
 Leu His Asn Lys Pro Thr Phe Ser Gln Glu Val Phe Thr Glu Leu Gln
                  40                  45                  50

 gag aag tat ggg gag att gaa gag atg aat gtg tgc gac aac ctt ggg      248
 Glu Lys Tyr Gly Glu Ile Glu Glu Met Asn Val Cys Asp Asn Leu Gly
              55                  60                  65

 gac cac ctc gtg ggc aac gtc tat gtc aag ttc cgg agg gag gag gat      296
 Asp His Leu Val Gly Asn Val Tyr Val Lys Phe Arg Arg Glu Glu Asp
          70                  75                  80

 gga gag cgg gcc gtg gct gaa ctc agt aac cgc tgg ttc aac ggg cag      344
 Gly Glu Arg Ala Val Ala Glu Leu Ser Asn Arg Trp Phe Asn Gly Gln
      85                  90                  95

 gct gtg cac ggg aat gta ccc gag gtg gct tct gca act tca tgc atc      392
 Ala Val His Gly Asn Val Pro Glu Val Ala Ser Ala Thr Ser Cys Ile
 100                 105                 110                 115

 tgc ggc cca ttt ccc aga acc tcc aga ggc agc tct atg ggc ggg gac      440
 Cys Gly Pro Phe Pro Arg Thr Ser Arg Gly Ser Ser Met Gly Gly Asp
                 120                 125                 130

 cca ggc gca ggt cac ccc cga ggt tcc ata ctg gcc acc atc ccc gag      488
 Pro Gly Ala Gly His Pro Arg Gly Ser Ile Leu Ala Thr Ile Pro Glu
             135                 140                 145

 aga gga acc atc ggt gtt ccc ctg atc act ggc atg gcc gct tct gag      536
 Arg Gly Thr Ile Gly Val Pro Leu Ile Thr Gly Met Ala Ala Ser Glu
         150                 155                 160

 gcc ctg gcc ccc tta ccc ttc acc ccc aac agg gac aga tgt tcc tgg      584
 Ala Leu Ala Pro Leu Pro Phe Thr Pro Asn Arg Asp Arg Cys Ser Trp
     165                 170                 175

 cag gac ctc tcc tca aag ccc cct tca ctc tcc tgc ccc atc ctt ccc      632
 Gln Asp Leu Ser Ser Lys Pro Pro Ser Leu Ser Cys Pro Ile Leu Pro
 180                 185                 190                 195

 agg ctc ccg ggc tcc ata atg taa tctgttcagc atggagacct tcttctaccg     686
 Arg Leu Pro Gly Ser Ile Met 
                 200

 cccctgtctt aata                                                      700




      <210> 55
      <211> 855
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(773)

      <400> 55
 taccggtccg gaattcccgg gtcgacgatt tcgtggcttg ggtaaaa  atg gct gaa      56
                                                      Met Ala Glu
                                                        1

 tat tta gct tcg ata ttc ggg act gag aag gac aag gtt aac tgc tct      104
 Tyr Leu Ala Ser Ile Phe Gly Thr Glu Lys Asp Lys Val Asn Cys Ser
       5                  10                  15

 ttt tac ttt aag att ggc gcc tgc cgg cac ggg gac cgg tgc tcc cga      152
 Phe Tyr Phe Lys Ile Gly Ala Cys Arg His Gly Asp Arg Cys Ser Arg
  20                  25                  30                  35

 ctt cac aac aaa ccg act ttc agc cag acc ata gtc ctg ctc aac ttg      200
 Leu His Asn Lys Pro Thr Phe Ser Gln Thr Ile Val Leu Leu Asn Leu
                  40                  45                  50

 tac cgg aat cca cag aac aca gcc caa act gca gac gga tca cac tgt      248
 Tyr Arg Asn Pro Gln Asn Thr Ala Gln Thr Ala Asp Gly Ser His Cys
              55                  60                  65

 cat gtg agc gac gtg gag gtg cag gag cac tat gat agc ttc ttc gag      296
 His Val Ser Asp Val Glu Val Gln Glu His Tyr Asp Ser Phe Phe Glu
          70                  75                  80

 gag gtg ttc aca gaa ctg cag gag aag tat ggg gag att gaa gag atg      344
 Glu Val Phe Thr Glu Leu Gln Glu Lys Tyr Gly Glu Ile Glu Glu Met
      85                  90                  95

 aat gtg tgc gac aac ctt ggg gac cac ctc gtg ggc aac gtc tat gtc      392
 Asn Val Cys Asp Asn Leu Gly Asp His Leu Val Gly Asn Val Tyr Val
 100                 105                 110                 115

 aag ttc cgg agg gag gag gat gga gag cgg gcc gtg gct gaa ctc agt      440
 Lys Phe Arg Arg Glu Glu Asp Gly Glu Arg Ala Val Ala Glu Leu Ser
                 120                 125                 130

 aac cgc tgg ttc aac ggg cag gct gtg cac ggg aat gta ccc gag gtg      488
 Asn Arg Trp Phe Asn Gly Gln Ala Val His Gly Asn Val Pro Glu Val
             135                 140                 145

 gct tct gca act tca tgc atc tgc ggc cca ttt ccc aga acc tcc aga      536
 Ala Ser Ala Thr Ser Cys Ile Cys Gly Pro Phe Pro Arg Thr Ser Arg
         150                 155                 160

 ggc agc tct atg ggc ggg gac cca ggc gca ggt cac ccc cga ggt tcc      584
 Gly Ser Ser Met Gly Gly Asp Pro Gly Ala Gly His Pro Arg Gly Ser
     165                 170                 175

 ata ctg gcc acc atc ccc gag aga gga acc atc gtt gtt ccc ctg atc      632
 Ile Leu Ala Thr Ile Pro Glu Arg Gly Thr Ile Val Val Pro Leu Ile
 180                 185                 190                 195

 act ggc atg gcc gct tct gag gcc ctg gcc ccc tta ccc ttc acc ccc      680
 Thr Gly Met Ala Ala Ser Glu Ala Leu Ala Pro Leu Pro Phe Thr Pro
                 200                 205                 210

 aac agg gac aga tgt tcc tgg cag gac ctc tcc tca aag ccc cct tca      728
 Asn Arg Asp Arg Cys Ser Trp Gln Asp Leu Ser Ser Lys Pro Pro Ser
             215                 220                 225

 ctc tcc tgc ccc atc ctt ccc agg ctc ccg ggc tcc ata atg taa tct      776
 Leu Ser Cys Pro Ile Leu Pro Arg Leu Pro Gly Ser Ile Met 
         230                 235                 240

 gttcagcatg gagaccttct tctactgccc ctgtcttaat aaagctgcgt gtttcacttc    836

 ggcatcaaaa aaaaaaaaa                                                 855




      <210> 56
      <211> 3068
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(2512)

      <400> 56
 atgtctctgc cggacccagg ccaccggcgc agaaaacgct gccacctgga cgtcccccac     60

 ttcgcgcacg cactctggtg cttgcatata aataaccccg ggcccggccc cggccccccg    120

 ccaagcc  atg ctg tgc ggc cgc tgg agg cgt tgc cgc cgc ccg ccc gag     169
          Met Leu Cys Gly Arg Trp Arg Arg Cys Arg Arg Pro Pro Glu
            1               5                  10

 gag ccc cca gtg gcc gcc cag gtc gca gcc caa gtc gcg gcg ccg gtc      217
 Glu Pro Pro Val Ala Ala Gln Val Ala Ala Gln Val Ala Ala Pro Val
  15                  20                  25                  30

 gct ctc ccg tcc ccg ccg act ccc tcc gat ggc ggc acc aag agg ccc      265
 Ala Leu Pro Ser Pro Pro Thr Pro Ser Asp Gly Gly Thr Lys Arg Pro
                  35                  40                  45

 ggg ctg cgg gcg ctg aag aag atg ggc ctg acg gag gac gag gac gtg      313
 Gly Leu Arg Ala Leu Lys Lys Met Gly Leu Thr Glu Asp Glu Asp Val
              50                  55                  60

 cgc gcc atg ctg cgg ggc tcc cgg ctc cgc aag atc cgc tcg cgc acg      361
 Arg Ala Met Leu Arg Gly Ser Arg Leu Arg Lys Ile Arg Ser Arg Thr
          65                  70                  75

 tgg cac aag gag cgg ctg tac cgg ctg cag gag gac ggc ctg agc gtg      409
 Trp His Lys Glu Arg Leu Tyr Arg Leu Gln Glu Asp Gly Leu Ser Val
      80                  85                  90

 tgg ttc cag cgg cgc atc ccg cgt gcg cca tcg cag cac atc ttc ttc      457
 Trp Phe Gln Arg Arg Ile Pro Arg Ala Pro Ser Gln His Ile Phe Phe
  95                 100                 105                 110

 gtg cag cac atc gag gcg gtc cgc gag ggc cac cag tcc gag ggc ctg      505
 Val Gln His Ile Glu Ala Val Arg Glu Gly His Gln Ser Glu Gly Leu
                 115                 120                 125

 cgg cgc ttc ggg ggt gcc ttc gcg cca gcg cgc tgc ctc acc atc gcc      553
 Arg Arg Phe Gly Gly Ala Phe Ala Pro Ala Arg Cys Leu Thr Ile Ala
             130                 135                 140

 ttc aag ggc cgc cgc aag aac ctg gac ctg gcg gcg ccc acg gct gag      601
 Phe Lys Gly Arg Arg Lys Asn Leu Asp Leu Ala Ala Pro Thr Ala Glu
         145                 150                 155

 gaa gcg cag cgc tgg gtg cgc ggt ctg acc aag ctc cgc gcg cgc ctg      649
 Glu Ala Gln Arg Trp Val Arg Gly Leu Thr Lys Leu Arg Ala Arg Leu
     160                 165                 170

 gac gcc atg agc cag cgc gag cgg cta gac cac tgg atc cac tcc tat      697
 Asp Ala Met Ser Gln Arg Glu Arg Leu Asp His Trp Ile His Ser Tyr
 175                 180                 185                 190

 ctg cac cgg gct gac tcc aac cag gac agc aag atg agc ttc aag gag      745
 Leu His Arg Ala Asp Ser Asn Gln Asp Ser Lys Met Ser Phe Lys Glu
                 195                 200                 205

 atc aag agc ctg ctg aga atg gtc aac gtg gac atg aac gac atg tac      793
 Ile Lys Ser Leu Leu Arg Met Val Asn Val Asp Met Asn Asp Met Tyr
             210                 215                 220

 gcc tac ctc ctc ttc aag gag tgt gac cac tcc aac aac gac cgt cta      841
 Ala Tyr Leu Leu Phe Lys Glu Cys Asp His Ser Asn Asn Asp Arg Leu
         225                 230                 235

 gag ggg gct gag atc gag gag ttc ctg cgg cgg ctg ctg aag cgg ccg      889
 Glu Gly Ala Glu Ile Glu Glu Phe Leu Arg Arg Leu Leu Lys Arg Pro
     240                 245                 250

 gag ctg gag gag atc ttc cat cag tac tcg ggc gag gac cgc gtg ctg      937
 Glu Leu Glu Glu Ile Phe His Gln Tyr Ser Gly Glu Asp Arg Val Leu
 255                 260                 265                 270

 agt gcc cct gag ctg ctg gag ttc ctg gag gac cag ggc gag gag ggc      985
 Ser Ala Pro Glu Leu Leu Glu Phe Leu Glu Asp Gln Gly Glu Glu Gly
                 275                 280                 285

 gcc aca ctg gcc cgc gcc cag cag ctc att cag acc tat gag ctc aac     1033
 Ala Thr Leu Ala Arg Ala Gln Gln Leu Ile Gln Thr Tyr Glu Leu Asn
             290                 295                 300

 gag aca gcc aag cag cat gag ctg atg aca ctg gat ggc ttc atg atg     1081
 Glu Thr Ala Lys Gln His Glu Leu Met Thr Leu Asp Gly Phe Met Met
         305                 310                 315

 tac ctg ttg tcg ccg gag ggg gct gcc ttg gac aac acc cac acg tgt     1129
 Tyr Leu Leu Ser Pro Glu Gly Ala Ala Leu Asp Asn Thr His Thr Cys
     320                 325                 330

 gtg ttc cag gac atg aac cag ccc ctt gcc cac tac ttc atc tct tcc     1177
 Val Phe Gln Asp Met Asn Gln Pro Leu Ala His Tyr Phe Ile Ser Ser
 335                 340                 345                 350

 tcc cac aac acc tat ctg act gac tcc cag atc ggg ggg ccc agc agc     1225
 Ser His Asn Thr Tyr Leu Thr Asp Ser Gln Ile Gly Gly Pro Ser Ser
                 355                 360                 365

 acc gag gcc tat gtt agg tac tgt agc agg ggg gcc ttt gcc cag gga     1273
 Thr Glu Ala Tyr Val Arg Tyr Cys Ser Arg Gly Ala Phe Ala Gln Gly
             370                 375                 380

 tgc cgc tgc gtg gag ctg gac tgc tgg gag ggg cca gga ggg gag ccc     1321
 Cys Arg Cys Val Glu Leu Asp Cys Trp Glu Gly Pro Gly Gly Glu Pro
         385                 390                 395

 gtc atc tat cat ggc cat acc ctc acc tcc aag att ctc ttc cgg gac     1369
 Val Ile Tyr His Gly His Thr Leu Thr Ser Lys Ile Leu Phe Arg Asp
     400                 405                 410

 gtg gtc caa gcc gtg cgc gac cat gcc ttc acg ctg tcc cct tac cct     1417
 Val Val Gln Ala Val Arg Asp His Ala Phe Thr Leu Ser Pro Tyr Pro
 415                 420                 425                 430

 gtc atc cta tcc ctg gag aac cac tgc ggg ctg gag cag cag gct gcc     1465
 Val Ile Leu Ser Leu Glu Asn His Cys Gly Leu Glu Gln Gln Ala Ala
                 435                 440                 445

 atg gcc cgc cac ctc tgc acc atc ctg ggg gac atg ctg gtg aca cag     1513
 Met Ala Arg His Leu Cys Thr Ile Leu Gly Asp Met Leu Val Thr Gln
             450                 455                 460

 gcg ctg gac tcc cca aat ccc gag gag ctg cca tcc cca gag cag ctg     1561
 Ala Leu Asp Ser Pro Asn Pro Glu Glu Leu Pro Ser Pro Glu Gln Leu
         465                 470                 475

 aag ggc cgg gtc ctg gtg aag gga aag aag ctg ccc gct gct cgg agc     1609
 Lys Gly Arg Val Leu Val Lys Gly Lys Lys Leu Pro Ala Ala Arg Ser
     480                 485                 490

 gag gat ggc cgg gct ctg tcg gat cgg gag gag gag gag gag gat gac     1657
 Glu Asp Gly Arg Ala Leu Ser Asp Arg Glu Glu Glu Glu Glu Asp Asp
 495                 500                 505                 510

 gag gag gaa gaa gag gag gtg gag gct gca gcg cag agg cgg ctg gcc     1705
 Glu Glu Glu Glu Glu Glu Val Glu Ala Ala Ala Gln Arg Arg Leu Ala
                 515                 520                 525

 aag cag atc tcc ccg gag ctg tcg gcc ctg gct gtg tac tgc cac gcc     1753
 Lys Gln Ile Ser Pro Glu Leu Ser Ala Leu Ala Val Tyr Cys His Ala
             530                 535                 540

 acc cgc ctg cgg acc ctg cac cct gcc ccc aac gcc cca caa ccc tgc     1801
 Thr Arg Leu Arg Thr Leu His Pro Ala Pro Asn Ala Pro Gln Pro Cys
         545                 550                 555

 cag gtc agc tcc ctc agc gag cgc aaa gcc aag aaa ctc att cgg gag     1849
 Gln Val Ser Ser Leu Ser Glu Arg Lys Ala Lys Lys Leu Ile Arg Glu
     560                 565                 570

 gca ggg aac agc ttt gtc agg cac aat gcc cgc cag ctg acc cgc gtg     1897
 Ala Gly Asn Ser Phe Val Arg His Asn Ala Arg Gln Leu Thr Arg Val
 575                 580                 585                 590

 tac ccg ctg ggg ctg cgg atg aac tca gcc aac tac agt ccc cag gag     1945
 Tyr Pro Leu Gly Leu Arg Met Asn Ser Ala Asn Tyr Ser Pro Gln Glu
                 595                 600                 605

 atg tgg aac tcg ggc tgt cag ctg gtg gcc ttg aac ttc cag acg cca     1993
 Met Trp Asn Ser Gly Cys Gln Leu Val Ala Leu Asn Phe Gln Thr Pro
             610                 615                 620

 ggc tac gag atg gac ctc aat gcc ggg cgc ttc cta gtc aat ggg cag     2041
 Gly Tyr Glu Met Asp Leu Asn Ala Gly Arg Phe Leu Val Asn Gly Gln
         625                 630                 635

 tgt ggc tac gtc cta aaa cct gcc tgc ctg cgg caa cct gac tcg acc     2089
 Cys Gly Tyr Val Leu Lys Pro Ala Cys Leu Arg Gln Pro Asp Ser Thr
     640                 645                 650

 ttt gac ccc gag tac cca gga cct ccc aga acc act ctc agc atc cag     2137
 Phe Asp Pro Glu Tyr Pro Gly Pro Pro Arg Thr Thr Leu Ser Ile Gln
 655                 660                 665                 670

 gtg ctg act gca cag cag ctg ccc aag ctg aat gcc gag aag cca cac     2185
 Val Leu Thr Ala Gln Gln Leu Pro Lys Leu Asn Ala Glu Lys Pro His
                 675                 680                 685

 tcc att gtg gac ccc ctg gtg cgc att gag atc cat ggg gtg ccc gca     2233
 Ser Ile Val Asp Pro Leu Val Arg Ile Glu Ile His Gly Val Pro Ala
             690                 695                 700

 gac tgt gcc cgg cag gag act gac tac gtg ctc aac aat ggc ttc aac     2281
 Asp Cys Ala Arg Gln Glu Thr Asp Tyr Val Leu Asn Asn Gly Phe Asn
         705                 710                 715

 ccc cgc tgg ggg cag acc ctg cag ttc cag ctg cgg gct ccg gag ctg     2329
 Pro Arg Trp Gly Gln Thr Leu Gln Phe Gln Leu Arg Ala Pro Glu Leu
     720                 725                 730

 gca ctg gtc cgg ttt gtg gtg gaa gat tat gac gcc acc tcc ccc aat     2377
 Ala Leu Val Arg Phe Val Val Glu Asp Tyr Asp Ala Thr Ser Pro Asn
 735                 740                 745                 750

 gac ttt gtg ggc cag ttt aca ctg cct ctt agc agc cta aag caa ggg     2425
 Asp Phe Val Gly Gln Phe Thr Leu Pro Leu Ser Ser Leu Lys Gln Gly
                 755                 760                 765

 tac cgc cac ata cac ctg ctt tcc aag gac ggg gcc tca ctg tca cca     2473
 Tyr Arg His Ile His Leu Leu Ser Lys Asp Gly Ala Ser Leu Ser Pro
             770                 775                 780

 gcc acg ctc ttc atc caa atc cgc atc cag cgc tcc tga gggcccacct      2522
 Ala Thr Leu Phe Ile Gln Ile Arg Ile Gln Arg Ser 
         785                 790

 cactcgcctt ggggttctgc gagtgccagt ccacatcccc tgcagagccc tctcctcctc   2582

 tggagtcagg tggtgggagt accagccccc cagcccaccc acttggccca ctcagcccat   2642

 tcaccaggcg ctggtctcac ctgggtgctg agggctgcct gggcccctcc tgaagaacag   2702

 aaaggtgttc atgtgacttc agtgagctcc aaccctgggg ccctgagatg gccccagctc   2762

 ctcttgtcct cagcccaccc ctcattgtga cttatgagga gcaagcctgt tgctgccagg   2822

 agacttgggg agcaggacac ttgtgggccc tcagttcccc tctgtcctcc cgtgggccat   2882

 cccagcctcc ttcccccaga ggagcgcagt cactccactt ggccccgacc ccgagcttag   2942

 cccctaagcc ctcctttacc ccaggccttc ctggactcct ccctccagct ccggaacctg   3002

 agctcccctt cccttctcaa agcaagaagg gagcgctgag gcatgaagcc ctggggaaac   3062

 tggcag                                                              3068




      <210> 57
      <211> 719
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (343)..(690)

      <400> 57
 gcggggatta acttgccacc actcccctgg tccagcattt ggccaaggca gacactgagg     60

 ctctgatgac aagtggcttt cccaaggaag gtcctgctgc ccagaagagc ttggcccaga    120

 gccctgtgcc cagtgacccc actagctttt ccctctactt tccccgcctg gctgtgctcc    180

 ccttgattcg tgcctattgg ccgtgcccat agtctctccc aagctcaaag ttcacctctt    240

 tctccagatc ccctggggtc cccaagcctg actcagtgta tctggggggg tcccttctga    300

 gcccacgcac cgacccagct cctcttccct gcagttgtgg cc   atg gcg gct gtg     354
                                                  Met Ala Ala Val
                                                    1

 ccc atg gtg ctc agt gcc atg ggc ttc act gcg gcg gga atc gcc tcg      402
 Pro Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser
   5                  10                  15                  20

 tcc tcc ata gca gcc aag atg atg tcc gca gca gcc att gcc aac ggg      450
 Ser Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly
                  25                  30                  35

 ggt ggt gtt tct gcg ggg agc ctg gtg gct act ctg cag tcc gtg ggg      498
 Gly Gly Val Ser Ala Gly Ser Leu Val Ala Thr Leu Gln Ser Val Gly
              40                  45                  50

 gca gct gga ctc tcc aca tca tcc aac atc ctc ctg gcc tct gtt ggg      546
 Ala Ala Gly Leu Ser Thr Ser Ser Asn Ile Leu Leu Ala Ser Val Gly
          55                  60                  65

 tca gtg ttg ggg gcc tgc ttg ggg aat tca cct tct tct tct ctc cca      594
 Ser Val Leu Gly Ala Cys Leu Gly Asn Ser Pro Ser Ser Ser Leu Pro
      70                  75                  80

 gct gaa ccc gag gct aaa gaa gat gag gca aga gaa aat gta ccc caa      642
 Ala Glu Pro Glu Ala Lys Glu Asp Glu Ala Arg Glu Asn Val Pro Gln
  85                  90                  95                 100

 ggt gaa cct cca aaa ccc cca ctc aag tca gag aaa cat gag gaa taa      690
 Gly Glu Pro Pro Lys Pro Pro Leu Lys Ser Glu Lys His Glu Glu 
                 105                 110                 115

 aggtcacatg cagatgcaaa aaaaaaaaa                                      719




      <210> 58
      <211> 1256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(1021)

      <400> 58
 tctggaattc gcggccgcgt cgacggctcg gccacttcag aagccccagc ctcgacctag     60

 cccaccctct cagggccaca gtgcagaagc ctgcacacct gccaagtctc tccgactcct    120

 tgcagctgct gtcagc    atg gcc cag gct cct gct gac ccg ggc aga gaa     169
                      Met Ala Gln Ala Pro Ala Asp Pro Gly Arg Glu
                        1               5                  10

 gcc aag agg ccc cag caa cat gca gct aca att cca gag acc cct ggc      217
 Ala Lys Arg Pro Gln Gln His Ala Ala Thr Ile Pro Glu Thr Pro Gly
              15                  20                  25

 cct cag ttc agc caa caa cgg gag gaa gac atc tac agg ttt ctc aaa      265
 Pro Gln Phe Ser Gln Gln Arg Glu Glu Asp Ile Tyr Arg Phe Leu Lys
          30                  35                  40

 gac aat ggt ccc cag agg gcc ctg gtc atc gcc caa gca ctg gga atg      313
 Asp Asn Gly Pro Gln Arg Ala Leu Val Ile Ala Gln Ala Leu Gly Met
      45                  50                  55

 agg aca gca aaa gat gtg aac cga gac ttg tac agg atg aag agc agg      361
 Arg Thr Ala Lys Asp Val Asn Arg Asp Leu Tyr Arg Met Lys Ser Arg
  60                  65                  70                  75

 cac ctt ctg gac atg gat gag cag tcc aaa gca tgg acg att tac cgc      409
 His Leu Leu Asp Met Asp Glu Gln Ser Lys Ala Trp Thr Ile Tyr Arg
                  80                  85                  90

 cca gaa gat tct gga aga aga gca aag tca gcc tca att att tac cag      457
 Pro Glu Asp Ser Gly Arg Arg Ala Lys Ser Ala Ser Ile Ile Tyr Gln
              95                 100                 105

 cac aat cca atc aac atg atc tgc cag aat gga ccc aac agc tgg att      505
 His Asn Pro Ile Asn Met Ile Cys Gln Asn Gly Pro Asn Ser Trp Ile
         110                 115                 120

 tcc att gca aac tcc gaa gcc atc cag att gga cac ggg aac atc att      553
 Ser Ile Ala Asn Ser Glu Ala Ile Gln Ile Gly His Gly Asn Ile Ile
     125                 130                 135

 aca aga cag aca gtc tcc agg gag gac ggt tcc gcc ggt cca cgc cac      601
 Thr Arg Gln Thr Val Ser Arg Glu Asp Gly Ser Ala Gly Pro Arg His
 140                 145                 150                 155

 ctc cct tca atg gca cca ggt gat tcc tca act tgg ggg acc cta gtt      649
 Leu Pro Ser Met Ala Pro Gly Asp Ser Ser Thr Trp Gly Thr Leu Val
                 160                 165                 170

 gat ccc tgg ggg ccc cag gac atc cac atg gag cgg tcc ata ctg aga      697
 Asp Pro Trp Gly Pro Gln Asp Ile His Met Glu Arg Ser Ile Leu Arg
             175                 180                 185

 cgg gtg cag ctg gga cac agc aat gag atg agg ctc cac ggc gtc ccg      745
 Arg Val Gln Leu Gly His Ser Asn Glu Met Arg Leu His Gly Val Pro
         190                 195                 200

 tcc gag ggc cct gcc cac atc ccc cct ggc agc ccc cca gtc tct gcc      793
 Ser Glu Gly Pro Ala His Ile Pro Pro Gly Ser Pro Pro Val Ser Ala
     205                 210                 215

 act gct gcc ggc cca gaa gct tcg ttt gaa gca aga att ccc agt cca      841
 Thr Ala Ala Gly Pro Glu Ala Ser Phe Glu Ala Arg Ile Pro Ser Pro
 220                 225                 230                 235

 gga act cac cct gag ggg gaa gcc gcc cag aga atc cac atg aaa tcg      889
 Gly Thr His Pro Glu Gly Glu Ala Ala Gln Arg Ile His Met Lys Ser
                 240                 245                 250

 tgc ttt ctc gag gac gcc acc atc ggc aac agc aac aaa atg tct atc      937
 Cys Phe Leu Glu Asp Ala Thr Ile Gly Asn Ser Asn Lys Met Ser Ile
             255                 260                 265

 cag ccc agg ggt ggc tgg ccc agg agg agt cgc agg gtc tgg aga ggg      985
 Gln Pro Arg Gly Gly Trp Pro Arg Arg Ser Arg Arg Val Trp Arg Gly
         270                 275                 280

 gga gcc agg gga gga cgc agt tgc tgc ctt cac tga agtc ttgaacccct     1035
 Gly Ala Arg Gly Gly Arg Ser Cys Cys Leu His 
     285                 290

 caaagtcatt catgaaattt ggaatcaact tcttccagac tcctgtgaat gttgatagtt   1095

 tgacctcctc ccatgaatca caaatgttct taacggcatg tagattggtg atcttttcca   1155

 gaagattttc aacttacttt gcccagatcc atctgaggaa tcactctgtg ttgcacttat   1215

 gccctcataa aatatattta ttgaagaata aaaaaaaaaa a                       1256




      <210> 59
      <211> 1129
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(1101)

      <400> 59
 aaattcaaaa ccccagcgtg ccagttagta ttccaaaaag caaagaaaaa cagggacgtc     60

 cacccaggtg cattggtgcc agcatcttca ctgaaaggag gtaatctggg ctct  atg     117
                                                              Met
                                                                1

 tca gtc cgt tct aaa ttg cca aat tct cca gca gca tct tct cat ccc      165
 Ser Val Arg Ser Lys Leu Pro Asn Ser Pro Ala Ala Ser Ser His Pro
               5                  10                  15

 aag ctc aag tct tca aaa ggc ata acg aag aaa ccg cag gct cct tca      213
 Lys Leu Lys Ser Ser Lys Gly Ile Thr Lys Lys Pro Gln Ala Pro Ser
          20                  25                  30

 aac aat gca tca tct tca ctt gct tca tta aat cca gta ggt aaa aac      261
 Asn Asn Ala Ser Ser Ser Leu Ala Ser Leu Asn Pro Val Gly Lys Asn
      35                  40                  45

 act tct tca cca gct tta cca aga act gca cct tgt ata tct gag tca      309
 Thr Ser Ser Pro Ala Leu Pro Arg Thr Ala Pro Cys Ile Ser Glu Ser
  50                  55                  60                  65

 ccg aga aaa tgt att tca tcc ccc aat acc ccc aag gcc aag gtt att      357
 Pro Arg Lys Cys Ile Ser Ser Pro Asn Thr Pro Lys Ala Lys Val Ile
                  70                  75                  80

 cca gcc cag aat tca gca gat ctg ccc gag tcc aca ctt ttg cca aat      405
 Pro Ala Gln Asn Ser Ala Asp Leu Pro Glu Ser Thr Leu Leu Pro Asn
              85                  90                  95

 aag tgt tca gga aaa act caa cct aag tat ttg aaa cat aac cat att      453
 Lys Cys Ser Gly Lys Thr Gln Pro Lys Tyr Leu Lys His Asn His Ile
         100                 105                 110

 tct tcc aga gat aat gca gta tct cac tta gct gca cat tca aat tca      501
 Ser Ser Arg Asp Asn Ala Val Ser His Leu Ala Ala His Ser Asn Ser
     115                 120                 125

 tcc tca aaa tgt ccc aag ctg cct aaa gca aat ata cct gta aga cct      549
 Ser Ser Lys Cys Pro Lys Leu Pro Lys Ala Asn Ile Pro Val Arg Pro
 130                 135                 140                 145

 aaa cct tct ttc cag tcc tct gca aaa atg aca aaa acc agt tcc aaa      597
 Lys Pro Ser Phe Gln Ser Ser Ala Lys Met Thr Lys Thr Ser Ser Lys
                 150                 155                 160

 acc ata gcc acg ggt cta gga aca cag tct caa cca tcc gat gga gcc      645
 Thr Ile Ala Thr Gly Leu Gly Thr Gln Ser Gln Pro Ser Asp Gly Ala
             165                 170                 175

 cca caa gca aag cca gtc cca gca cag aaa ctt aaa tcg gcc ttg aat      693
 Pro Gln Ala Lys Pro Val Pro Ala Gln Lys Leu Lys Ser Ala Leu Asn
         180                 185                 190

 tta aat cag cca gtt tct gtg tcc tca gtt tct cct gta aaa gcc aca      741
 Leu Asn Gln Pro Val Ser Val Ser Ser Val Ser Pro Val Lys Ala Thr
     195                 200                 205

 cag aaa tca aaa gat aag aat ata gtt tca gct acc aaa aag cag cct      789
 Gln Lys Ser Lys Asp Lys Asn Ile Val Ser Ala Thr Lys Lys Gln Pro
 210                 215                 220                 225

 cag aat aaa agt gca ttt cag aag aca gga ccc agc tcc ttg aag tct      837
 Gln Asn Lys Ser Ala Phe Gln Lys Thr Gly Pro Ser Ser Leu Lys Ser
                 230                 235                 240

 cct ggc cgt acc cca ctg tcc atc gtg agc cta ccc cag tct tct acc      885
 Pro Gly Arg Thr Pro Leu Ser Ile Val Ser Leu Pro Gln Ser Ser Thr
             245                 250                 255

 aaa aca caa act gca ccg aag tca gca cag act gtc gct aag agc cag      933
 Lys Thr Gln Thr Ala Pro Lys Ser Ala Gln Thr Val Ala Lys Ser Gln
         260                 265                 270

 cat tca act aaa ggg cct ccc aga agt ggc aaa acc cca gct tca atc      981
 His Ser Thr Lys Gly Pro Pro Arg Ser Gly Lys Thr Pro Ala Ser Ile
     275                 280                 285

 agg aaa cca ccc tca tct gtt aag gat gca gat agt gga gat aaa aaa     1029
 Arg Lys Pro Pro Ser Ser Val Lys Asp Ala Asp Ser Gly Asp Lys Lys
 290                 295                 300                 305

 cct act gca aag aaa aag gaa gat gat gac cat tat ttt gtc atg act     1077
 Pro Thr Ala Lys Lys Lys Glu Asp Asp Asp His Tyr Phe Val Met Thr
                 310                 315                 320

 gga agt aag aaa cct aga aaa taa atacatactc attataaaaa aaaaaaaa      1129
 Gly Ser Lys Lys Pro Arg Lys 
             325





      <210> 60
      <211> 6383
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(5025)

      <400> 60
 ggcacgagct gtaggagcag gggcctagca agcgcccagc ggagcgaccc ctgcctggcc     60

 gtggctagc    atg gcc cct acg ctg ttc cag aag ctc ttc agc aag agg     108
              Met Ala Pro Thr Leu Phe Gln Lys Leu Phe Ser Lys Arg
                1               5                  10

 acc ggg ctg ggc gcg ccc ggc cgc gac gcc cgg gac cca gat tgc ggg      156
 Thr Gly Leu Gly Ala Pro Gly Arg Asp Ala Arg Asp Pro Asp Cys Gly
      15                  20                  25

 ttc agt tgg cct tta cca gag ttt gat cca agc cag att cga ctg att      204
 Phe Ser Trp Pro Leu Pro Glu Phe Asp Pro Ser Gln Ile Arg Leu Ile
  30                  35                  40                  45

 gta tat caa gac tgt gaa aga cga ggg aga aat gtt ttg ttt gac tcc      252
 Val Tyr Gln Asp Cys Glu Arg Arg Gly Arg Asn Val Leu Phe Asp Ser
                  50                  55                  60

 agt gtt aag aga aga aat gag gac ata tca gta tcg gac tta aat act      300
 Ser Val Lys Arg Arg Asn Glu Asp Ile Ser Val Ser Asp Leu Asn Thr
              65                  70                  75

 att tat tct tat ctt cat gga atg gaa ata tta tca aat ctc agg gaa      348
 Ile Tyr Ser Tyr Leu His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu
          80                  85                  90

 cat cag ctt aga tta atg tct gca aga gca cgc tat gag aga tac agt      396
 His Gln Leu Arg Leu Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser
      95                 100                 105

 ggc aat cag gtt ctc ttt tgt tca gaa acg att gcc aga tgt tgg tat      444
 Gly Asn Gln Val Leu Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr
 110                 115                 120                 125

 atc cta ctt tct gga tct gtg ctt gtg aaa ggc tcc atg gtc ttg cct      492
 Ile Leu Leu Ser Gly Ser Val Leu Val Lys Gly Ser Met Val Leu Pro
                 130                 135                 140

 cct tgc agt ttt ggt aag cag ttt gga gga aaa aga gga tgt gat tgt      540
 Pro Cys Ser Phe Gly Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys
             145                 150                 155

 ctt gta tta gag cct tca gaa atg att gtg gta gag aat gcc aaa gat      588
 Leu Val Leu Glu Pro Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp
         160                 165                 170

 aat gaa gat agt att cta caa aga gaa att cct gcc aga caa tcc cga      636
 Asn Glu Asp Ser Ile Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg
     175                 180                 185

 aga aga ttt cgg aaa att aac tat aaa gga gag cgc caa acc att act      684
 Arg Arg Phe Arg Lys Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr
 190                 195                 200                 205

 gat gat gtg gag gtt aac agc tat ctt tct ctt cca gct gat ctt acc      732
 Asp Asp Val Glu Val Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr
                 210                 215                 220

 aag atg cat ctc aca gaa aac cct cat cca cag gtg act cat gtg tct      780
 Lys Met His Leu Thr Glu Asn Pro His Pro Gln Val Thr His Val Ser
             225                 230                 235

 tct agt cag tct ggt tgt agc att gcc agt gac tct gga agc agc agt      828
 Ser Ser Gln Ser Gly Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser
         240                 245                 250

 tta tct gat atc tat cag gct acg gag agt gag gta gga gat gta gat      876
 Leu Ser Asp Ile Tyr Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp
     255                 260                 265

 ttg aca cgt ctt cca gaa gga cct gtt gat tct gag gat gac gaa gag      924
 Leu Thr Arg Leu Pro Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu
 270                 275                 280                 285

 gaa gat gaa gag att gat cga aca gat cca ttg cag ggg cga gat ctt      972
 Glu Asp Glu Glu Ile Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu
                 290                 295                 300

 gtt cga gaa tgt ctt gaa aaa gaa cct gca gac aaa act gat gat gac     1020
 Val Arg Glu Cys Leu Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp
             305                 310                 315

 att gaa caa ttg ctg gag ttt atg cac cag ctc cct gca ttt gca aac     1068
 Ile Glu Gln Leu Leu Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn
         320                 325                 330

 atg acc atg tct gta agg aga gaa ctc tgc tca gtg atg att ttt gaa     1116
 Met Thr Met Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu
     335                 340                 345

 gtg gta gag cag gct gga gct att att ctt gaa gat ggg caa gag ctt     1164
 Val Val Glu Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu
 350                 355                 360                 365

 gac tca tgg tat gtt att tta aac ggc act gtg gaa atc agt cat cca     1212
 Asp Ser Trp Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro
                 370                 375                 380

 gat gga aaa gtt gaa aat ttg ttt atg gga aat agt ttt gga att act     1260
 Asp Gly Lys Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr
             385                 390                 395

 ccc act ctg gat aag cag tac atg cat gga att gtc agg act aaa gta     1308
 Pro Thr Leu Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr Lys Val
         400                 405                 410

 gat gat tgt cag ttt gtc tgc ata gcc cag caa gat tat tgg aga att     1356
 Asp Asp Cys Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile
     415                 420                 425

 tta aac cat gtg gaa aaa aat acc cat aaa gtt gag gaa gag gga gaa     1404
 Leu Asn His Val Glu Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu
 430                 435                 440                 445

 att gtt atg gta cat gag cat cgg gaa cta gac cgg agt gga acc agg     1452
 Ile Val Met Val His Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg
                 450                 455                 460

 aaa gga cac att gtg atc aag gca aca cct gag cgt ctc ata atg cat     1500
 Lys Gly His Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His
             465                 470                 475

 tta ata gaa gaa cat tcc atc gtg gat cca act tat ata gaa gat ttt     1548
 Leu Ile Glu Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe
         480                 485                 490

 cta tta act tac agg aca ttt ctt gaa agt cct ttg gat gtt ggg atc     1596
 Leu Leu Thr Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile
     495                 500                 505

 aaa cta ttg gaa tgg ttt aag atc gac agc tta aga gat aag gtg aca     1644
 Lys Leu Leu Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr
 510                 515                 520                 525

 cgg att gta tta tta tgg gta aat aat cat ttt aat gat ttt gaa ggt     1692
 Arg Ile Val Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly
                 530                 535                 540

 gac cct gct atg act cga ttt cta gag gaa ttt gaa aaa aat ctg gaa     1740
 Asp Pro Ala Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu
             545                 550                 555

 gat aca aag atg aat ggt cat ctc cgg tta ttg aat att gcc tgt gct     1788
 Asp Thr Lys Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala
         560                 565                 570

 gca aag gct aag tgg aga cag gtt gtg ctg caa aag gct tcc cgc gag     1836
 Ala Lys Ala Lys Trp Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu
     575                 580                 585

 tcc cct cta caa ttc agc ctt aat gga ggg agt gag aag gga ttt ggt     1884
 Ser Pro Leu Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly
 590                 595                 600                 605

 att ttt gtt gaa gga gta gaa cct ggt agc aaa gct gct gat tca gga     1932
 Ile Phe Val Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly
                 610                 615                 620

 ctg aaa cgt ggt gat cag att atg gaa gta aat gga caa aac ttt gag     1980
 Leu Lys Arg Gly Asp Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu
             625                 630                 635

 aat att aca ttt atg aaa gcc gtt gaa att ttg agg aat aat act cat     2028
 Asn Ile Thr Phe Met Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His
         640                 645                 650

 ctt gca ctt act gtg aag acc aac att ttt gtg ttc aaa gag tta ctt     2076
 Leu Ala Leu Thr Val Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu
     655                 660                 665

 ttt agg act gaa caa gag aaa tct ggt gtt cct cat att ccc aaa att     2124
 Phe Arg Thr Glu Gln Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile
 670                 675                 680                 685

 gct gaa aaa aaa agt aat cgc cat tct atc cag cat gtg cca gga gat     2172
 Ala Glu Lys Lys Ser Asn Arg His Ser Ile Gln His Val Pro Gly Asp
                 690                 695                 700

 att gaa cag aca tca cag gag aaa gga agt aag aaa gtt aaa gca aat     2220
 Ile Glu Gln Thr Ser Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn
             705                 710                 715

 act gtt tca ggt gga aga aac aaa atc agg aag att ttg gat aaa aca     2268
 Thr Val Ser Gly Gly Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr
         720                 725                 730

 cga ttt agt atc ttg cct cca aag cta ttt agt gat gga ggc cta agc     2316
 Arg Phe Ser Ile Leu Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser
     735                 740                 745

 caa tca caa gat gac agc att gtg gga aca agg cac tgt agg cat agt     2364
 Gln Ser Gln Asp Asp Ser Ile Val Gly Thr Arg His Cys Arg His Ser
 750                 755                 760                 765

 ctg gct ata atg ccc atc cct gga aca ctc tca tcc agc agc cct gat     2412
 Leu Ala Ile Met Pro Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp
                 770                 775                 780

 ctc ctg cag cct acc acc agt atg ttg gat ttt tcc aat cct tca gat     2460
 Leu Leu Gln Pro Thr Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp
             785                 790                 795

 atc cct gat caa gtt ata aga gtt ttc aaa gtg gat cag caa agt tgc     2508
 Ile Pro Asp Gln Val Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys
         800                 805                 810

 tac att atc atc agt aaa gac acc aca gct aaa gaa gta gtt ttt cat     2556
 Tyr Ile Ile Ile Ser Lys Asp Thr Thr Ala Lys Glu Val Val Phe His
     815                 820                 825

 gct gtt cat gaa ttt ggt ttg acc ggt gca tcc gac aca tat tct ctc     2604
 Ala Val His Glu Phe Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu
 830                 835                 840                 845

 tgt gaa gtt tct gtt act cct gag ggt gtc ata aaa cag aga aga ctt     2652
 Cys Glu Val Ser Val Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu
                 850                 855                 860

 cca gat cag ttc tcc aaa tta gct gat aga att caa ctc aat gga agg     2700
 Pro Asp Gln Phe Ser Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg
             865                 870                 875

 tat tac tta aaa aat aac atg gaa aca gaa acc tta tgt tca gat gaa     2748
 Tyr Tyr Leu Lys Asn Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu
         880                 885                 890

 gat gct caa gaa cta gtt aag gaa agc cag cta tcc atg ctg cag ctc     2796
 Asp Ala Gln Glu Leu Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu
     895                 900                 905

 agt acc att gag gtg gcc acc cag ctg tca atg agg gac ttt gat ttg     2844
 Ser Thr Ile Glu Val Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu
 910                 915                 920                 925

 ttt cgt aat att gaa ccg act gag tac atc gat gac ctt ttt aag tta     2892
 Phe Arg Asn Ile Glu Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu
                 930                 935                 940

 aat tcc aaa aca gga aat act cat ttg aag agg ttt gag gac att gta     2940
 Asn Ser Lys Thr Gly Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val
             945                 950                 955

 aac caa gag aca ttc tgg gtt gcc tca gaa att tta act gaa gca aat     2988
 Asn Gln Glu Thr Phe Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn
         960                 965                 970

 cag ctc aaa cga atg aag att att aag cat ttt att aaa att gca ctt     3036
 Gln Leu Lys Arg Met Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu
     975                 980                 985

 cat tgt cga gaa tgt aag aac ttc aat tcc atg ttt gca ata ata agt     3084
 His Cys Arg Glu Cys Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser
 990                 995                1000                1005

 ggc ttg aac ctg gca tct gta gca aga ctc aga gga act tgg gaa aag     3132
 Gly Leu Asn Leu Ala Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys
                1010                1015                1020

 tta cca agc aaa tac gag aaa cat ctt caa gat cta caa gac att ttt     3180
 Leu Pro Ser Lys Tyr Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe
            1025                1030                1035

 gat cca tct aga aac atg gca aag tat aga aat att ctt agt agt caa     3228
 Asp Pro Ser Arg Asn Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln
        1040                1045                1050

 agt atg cag cct cca att att cca ctc ttc cct gtt gtc aag aaa gat     3276
 Ser Met Gln Pro Pro Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp
    1055                1060                1065

 atg aca ttt cta cat gaa gga aat gac tcc aaa gta gat ggt tta gta     3324
 Met Thr Phe Leu His Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val
1070                1075                1080                1085

 aac ttt gag aag tta agg atg att tcc aag gaa atc cgc caa gtt gtt     3372
 Asn Phe Glu Lys Leu Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val
                1090                1095                1100

 cga atg act tct gct aac atg gac cca gct atg atg ttt cga cag agg     3420
 Arg Met Thr Ser Ala Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg
            1105                1110                1115

 tca ctg agt caa gga agc aca aat tca aac atg ctg gat gtt cag gga     3468
 Ser Leu Ser Gln Gly Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly
        1120                1125                1130

 ggt gct cac aaa aaa agg gca cgc cgc agc tct ctg ctt aat gcc aag     3516
 Gly Ala His Lys Lys Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys
    1135                1140                1145

 aag cta tat gag gat gcc caa atg gca agg aag gtg aag cag tat ctt     3564
 Lys Leu Tyr Glu Asp Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu
1150                1155                1160                1165

 tcc agt ctc gat gta gag aca gat gag gag aag ttc cag atg atg tca     3612
 Ser Ser Leu Asp Val Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser
                1170                1175                1180

 tta cag tgg gag cct gca tat ggt acc ttg acc aag aat tta agt gag     3660
 Leu Gln Trp Glu Pro Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu
            1185                1190                1195

 aaa aga tca gcc aaa tca tct gaa atg tct cca gtg cct atg agg tca     3708
 Lys Arg Ser Ala Lys Ser Ser Glu Met Ser Pro Val Pro Met Arg Ser
        1200                1205                1210

 gct ggc caa aca act aaa gcc cac ttg cat caa ccc cac aga gta agc     3756
 Ala Gly Gln Thr Thr Lys Ala His Leu His Gln Pro His Arg Val Ser
    1215                1220                1225

 cag gtg ctt cag gtg cca gct gtt aat ttg cac ccc atc agg aag aag     3804
 Gln Val Leu Gln Val Pro Ala Val Asn Leu His Pro Ile Arg Lys Lys
1230                1235                1240                1245

 gga caa aca aaa gac cct gca ctg aat aca agt tta cct cag aaa gtt     3852
 Gly Gln Thr Lys Asp Pro Ala Leu Asn Thr Ser Leu Pro Gln Lys Val
                1250                1255                1260

 tta gga aca act gaa gaa ata agt ggt aag aag cat aca gaa gac act     3900
 Leu Gly Thr Thr Glu Glu Ile Ser Gly Lys Lys His Thr Glu Asp Thr
            1265                1270                1275

 att tct gtg gcg tca tct tta cat tct agt cct cct gca tct cct caa     3948
 Ile Ser Val Ala Ser Ser Leu His Ser Ser Pro Pro Ala Ser Pro Gln
        1280                1285                1290

 ggc tcc cct cac aaa ggt tac aca ctt att cca tca gct aaa tct gac     3996
 Gly Ser Pro His Lys Gly Tyr Thr Leu Ile Pro Ser Ala Lys Ser Asp
    1295                1300                1305

 aac ttg tct gac tcc agc cat agt gag att tct tca cgg tcc agc atc     4044
 Asn Leu Ser Asp Ser Ser His Ser Glu Ile Ser Ser Arg Ser Ser Ile
1310                1315                1320                1325

 gtg agc aat tgt tct gtt gac tcc atg tct gca gct cta cag gat gaa     4092
 Val Ser Asn Cys Ser Val Asp Ser Met Ser Ala Ala Leu Gln Asp Glu
                1330                1335                1340

 cgg tgt tcc tct cag gcc ctg gca gtc cct gaa tcc act ggg gca ttg     4140
 Arg Cys Ser Ser Gln Ala Leu Ala Val Pro Glu Ser Thr Gly Ala Leu
            1345                1350                1355

 gaa aag aca gag cac gct tca ggg ata gga gat cat agt caa cat ggc     4188
 Glu Lys Thr Glu His Ala Ser Gly Ile Gly Asp His Ser Gln His Gly
        1360                1365                1370

 cct ggg tgg aca ctc ttg aag cca tct cta atc aag tgt tta gct gtc     4236
 Pro Gly Trp Thr Leu Leu Lys Pro Ser Leu Ile Lys Cys Leu Ala Val
    1375                1380                1385

 tca tcg tct gtg agc aat gaa gag att tct caa gag cat atc att ata     4284
 Ser Ser Ser Val Ser Asn Glu Glu Ile Ser Gln Glu His Ile Ile Ile
1390                1395                1400                1405

 gaa gca gct gac agt ggt cgt gga agt tgg act tcg tgt tca agc agc     4332
 Glu Ala Ala Asp Ser Gly Arg Gly Ser Trp Thr Ser Cys Ser Ser Ser
                1410                1415                1420

 tcc cat gac aac ttc caa agc ctt cca aac cca aaa agc tgg gat ttt     4380
 Ser His Asp Asn Phe Gln Ser Leu Pro Asn Pro Lys Ser Trp Asp Phe
            1425                1430                1435

 ttg aac tct tac aga cat acc cat ttg gat gac ccc att gct gaa gtt     4428
 Leu Asn Ser Tyr Arg His Thr His Leu Asp Asp Pro Ile Ala Glu Val
        1440                1445                1450

 gaa ccc act gac tct gag ccc tat tcc tgt tct aaa agc tgc tct aga     4476
 Glu Pro Thr Asp Ser Glu Pro Tyr Ser Cys Ser Lys Ser Cys Ser Arg
    1455                1460                1465

 act tgt ggg cag tgt aaa gga agc cta gag aga aag agt tgg acc tcc     4524
 Thr Cys Gly Gln Cys Lys Gly Ser Leu Glu Arg Lys Ser Trp Thr Ser
1470                1475                1480                1485

 tcc agt tct ctg tct gac acg tat gaa cca aac tat ggg aca gtt aaa     4572
 Ser Ser Ser Leu Ser Asp Thr Tyr Glu Pro Asn Tyr Gly Thr Val Lys
                1490                1495                1500

 cgg aga gta ttg gag agc acc cca gct gag tca tct gaa ggc ttg gac     4620
 Arg Arg Val Leu Glu Ser Thr Pro Ala Glu Ser Ser Glu Gly Leu Asp
            1505                1510                1515

 ccc aag gat gcc act gac cca gtt tat aaa act gtc act tca agt aca     4668
 Pro Lys Asp Ala Thr Asp Pro Val Tyr Lys Thr Val Thr Ser Ser Thr
        1520                1525                1530

 gaa aag ggc ttg att gtg tac tgt gtc acc tca ccc aag aag gac gat     4716
 Glu Lys Gly Leu Ile Val Tyr Cys Val Thr Ser Pro Lys Lys Asp Asp
    1535                1540                1545

 agg tat agg gag cca cct ccc act cct cca gga tat ttg ggg att tct     4764
 Arg Tyr Arg Glu Pro Pro Pro Thr Pro Pro Gly Tyr Leu Gly Ile Ser
1550                1555                1560                1565

 tta gcg gac cta aag gaa gga ccc cac aca cac cta aaa cct cca gat     4812
 Leu Ala Asp Leu Lys Glu Gly Pro His Thr His Leu Lys Pro Pro Asp
                1570                1575                1580

 tat agt gtg gca gtg cag agg tca aag atg atg cat aac agc ctc tct     4860
 Tyr Ser Val Ala Val Gln Arg Ser Lys Met Met His Asn Ser Leu Ser
            1585                1590                1595

 aga ctg cca cca gct tct ctc agt agc aac ctc gtg gcc tgt gtt cca     4908
 Arg Leu Pro Pro Ala Ser Leu Ser Ser Asn Leu Val Ala Cys Val Pro
        1600                1605                1610

 tcg aag att gta act cag cct cag agg cat aat ttg cag cca ttc cat     4956
 Ser Lys Ile Val Thr Gln Pro Gln Arg His Asn Leu Gln Pro Phe His
    1615                1620                1625

 cct aaa cta gga gat gtg act gat gca gat agc gaa gca gat gaa aat     5004
 Pro Lys Leu Gly Asp Val Thr Asp Ala Asp Ser Glu Ala Asp Glu Asn
1630                1635                1640                1645

 gaa caa gtt tca gca gtc tag cc tttggatgac ctatttgaaa accactgaaa     5057
 Glu Gln Val Ser Ala Val 
                1650

 gtcgtggagg aatgggcaag aaccacctca tgattctgca ggccattgct aacgaacagc   5117

 tcattgctac aaccagtcca gaggttttat tccctctact ccgagcaatg aaatagacct   5177

 gagttatgct tcctttcatt taatttctgc agataaatag tttcctgagc aatggatgct   5237

 atgcctggat accagtctcc actttgcacg ccggaactgc cttgggacca cagttacaga   5297

 aaaaatgtaa actcagagtg atccttgtgt atattgctat agatttttct ttaacaagct   5357

 attttaaaga taatggcatt attatttcca agccatagct tgggctgaag gacaaattga   5417

 aattgtctgc caataccaag gatattcttg tatatttgaa aaataactta ttatttgaat   5477

 tgttgtggtt ttgtttgtat ttgagagctc ttgttagctg atattcatgt ttgaggtcat   5537

 aaaattgtct ctggtctgac caaacagaag tcatctttac agaggtgata tgcttgatct   5597

 acacagagat gtgacttgat ctgtagcacc aatgcaatgt aggtctcagt ttgagagaaa   5657

 taggaagccc tttgcagttg aggtgttagg aacctgctgg tcatggtgtg gaaggccaaa   5717

 tgaagctgcc acagggtttc ttgtcagtcc tttgggaaat gggagggagt agtttgggga   5777

 ggagggtggg aaccctaatt tccacagaat gaaattttga tgttaaatga catgtataca   5837

 aattcttcct taagtgaaag ttatgctgca tcgaattgta actgaaagta tagatccaac   5897

 aaatagagac tgggttctag agagttctgg tctatagaaa cccaaaacta aaatctctca   5957

 taactcaagt atggaatact ttttttaaag aaattcttat catgggtgtt gtaataatga   6017

 agacgaattt gactttatgc agtgttttgc agcatgcctc ccccacatct catagcacca   6077

 ggttgtgtct gacctgacat accctgcagc tctcagctgg ctgcagtaac attttgtggg   6137

 agaaagagga gctggagtta cagaaatgat tgtctcttgg ttctcagttt ttagcccttg   6197

 agaggacata cttttccagc ctcatgggta tggcactctt aattaaaatt tcagtgactg   6257

 tttactggat gaggcagatt tttcacattt ttgcaaatta aatatatttt atatatatta   6317

 agtttaattt tttcagtttt tttaatgtaa aagcaagtga aattttaata aacttctgta   6377

 attacc                                                              6383




      <210> 61
      <211> 5466
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(4306)

      <400> 61
 agccgccgcc ggggctgtag gcgccaaggc c   atg tcc gac tcg tgg gtc ccg      52
                                      Met Ser Asp Ser Trp Val Pro
                                        1               5

 aac tcc gcc tcg ggc cag gac cca ggg ggc cgc cgg agg gcc tgg gcc      100
 Asn Ser Ala Ser Gly Gln Asp Pro Gly Gly Arg Arg Arg Ala Trp Ala
          10                  15                  20

 gag ctg ctg gcg gga agg gtc aag agg gaa aaa tat aat cct gaa agg      148
 Glu Leu Leu Ala Gly Arg Val Lys Arg Glu Lys Tyr Asn Pro Glu Arg
      25                  30                  35

 gca cag aaa tta aag gaa tca gct gtg cgc ctc ctg cga agc cat cag      196
 Ala Gln Lys Leu Lys Glu Ser Ala Val Arg Leu Leu Arg Ser His Gln
  40                  45                  50                  55

 gac ctg aat gcc ctt ttg ctt gag gta gaa ggt cca ctg tgt aaa aaa      244
 Asp Leu Asn Ala Leu Leu Leu Glu Val Glu Gly Pro Leu Cys Lys Lys
                  60                  65                  70

 ttg tct ctc agc aaa gtg att gac tgt gac agt tct gag gcc tat gct      292
 Leu Ser Leu Ser Lys Val Ile Asp Cys Asp Ser Ser Glu Ala Tyr Ala
              75                  80                  85

 aat cat tct agt tca ttt ata ggc tct gct ttg cag gat caa gcc tca      340
 Asn His Ser Ser Ser Phe Ile Gly Ser Ala Leu Gln Asp Gln Ala Ser
          90                  95                 100

 agg ctg ggg gtt ccc gtg ggt att ctc tca gcc ggg atg gtt gcc tct      388
 Arg Leu Gly Val Pro Val Gly Ile Leu Ser Ala Gly Met Val Ala Ser
     105                 110                 115

 agc gtg gga cag atc tgc acg gct cca gcg gag acc agt cac cct gtg      436
 Ser Val Gly Gln Ile Cys Thr Ala Pro Ala Glu Thr Ser His Pro Val
 120                 125                 130                 135

 ctg ctg act gtg gag cag aga aag aag ctg tct tcc ctg tta gag ttt      484
 Leu Leu Thr Val Glu Gln Arg Lys Lys Leu Ser Ser Leu Leu Glu Phe
                 140                 145                 150

 gct cag tat tta ttg gca cac agt atg ttc tcc cgt ctt tcc ttc tgt      532
 Ala Gln Tyr Leu Leu Ala His Ser Met Phe Ser Arg Leu Ser Phe Cys
             155                 160                 165

 caa gaa tta tgg aaa ata cag agt tct ttg ttg ctt gaa gcg gtg tgg      580
 Gln Glu Leu Trp Lys Ile Gln Ser Ser Leu Leu Leu Glu Ala Val Trp
         170                 175                 180

 cat ctt cac gta caa ggc att gtg agc ctg caa gag ctg ctg gaa agc      628
 His Leu His Val Gln Gly Ile Val Ser Leu Gln Glu Leu Leu Glu Ser
     185                 190                 195

 cat ccc gac atg cat gct gtg gga tcg tgg ctc ttc agg aat ctg tgc      676
 His Pro Asp Met His Ala Val Gly Ser Trp Leu Phe Arg Asn Leu Cys
 200                 205                 210                 215

 tgc ctt tgt gaa cag atg gaa gca tcc tgc cag cat gct gac gtc gcc      724
 Cys Leu Cys Glu Gln Met Glu Ala Ser Cys Gln His Ala Asp Val Ala
                 220                 225                 230

 agg gcc atg ctt tct gat ttt gtt caa atg ttt gtt ttg agg gga ttt      772
 Arg Ala Met Leu Ser Asp Phe Val Gln Met Phe Val Leu Arg Gly Phe
             235                 240                 245

 cag aaa aac tca gat ctg aga aga act gtg gag cct gaa aaa atg ccg      820
 Gln Lys Asn Ser Asp Leu Arg Arg Thr Val Glu Pro Glu Lys Met Pro
         250                 255                 260

 cag gtc acg gtt gat gta ctg cag aga atg ctg att ttt gca ctt gac      868
 Gln Val Thr Val Asp Val Leu Gln Arg Met Leu Ile Phe Ala Leu Asp
     265                 270                 275

 gct ttg gct gct gga gta cag gag gag tcc tcc act cac aag atc gtg      916
 Ala Leu Ala Ala Gly Val Gln Glu Glu Ser Ser Thr His Lys Ile Val
 280                 285                 290                 295

 agg tgc tgg ttc gga gtg ttc agt gga cac acg ctt ggc agt gta att      964
 Arg Cys Trp Phe Gly Val Phe Ser Gly His Thr Leu Gly Ser Val Ile
                 300                 305                 310

 tcc aca gat cct ctg aag agg ttc ttc agt cat acc ctg act cag ata     1012
 Ser Thr Asp Pro Leu Lys Arg Phe Phe Ser His Thr Leu Thr Gln Ile
             315                 320                 325

 ctc act cac agc cct gtg ctg aaa gca tct gat gct gtt cag atg cag     1060
 Leu Thr His Ser Pro Val Leu Lys Ala Ser Asp Ala Val Gln Met Gln
         330                 335                 340

 aga gag tgg agc ttt gcg cgg aca cac cct ctg ctc acc tca ctg tac     1108
 Arg Glu Trp Ser Phe Ala Arg Thr His Pro Leu Leu Thr Ser Leu Tyr
     345                 350                 355

 cgc agg ctc ttt gtg atg ctg agt gca gag gag ttg gtt ggc cat ttg     1156
 Arg Arg Leu Phe Val Met Leu Ser Ala Glu Glu Leu Val Gly His Leu
 360                 365                 370                 375

 caa gaa gtt ctg gaa acg cag gag gtt cac tgg cag aga gtg ctc tcc     1204
 Gln Glu Val Leu Glu Thr Gln Glu Val His Trp Gln Arg Val Leu Ser
                 380                 385                 390

 ttt gtg tct gcc ctg gtt gtc tgc ttt cca gaa gcg cag cag ctg ctt     1252
 Phe Val Ser Ala Leu Val Val Cys Phe Pro Glu Ala Gln Gln Leu Leu
             395                 400                 405

 gaa gac tgg gtg gcg cgt ttg atg gcc cag gca ttc gag agc tgc cag     1300
 Glu Asp Trp Val Ala Arg Leu Met Ala Gln Ala Phe Glu Ser Cys Gln
         410                 415                 420

 ctg gac agc atg gtc act gcg ttc ctg gtt gtg cgc cag gca gca ctg     1348
 Leu Asp Ser Met Val Thr Ala Phe Leu Val Val Arg Gln Ala Ala Leu
     425                 430                 435

 gag ggc ccc tct gcg ttc ctg tca tat gca gac tgg ttc aag gcc tcc     1396
 Glu Gly Pro Ser Ala Phe Leu Ser Tyr Ala Asp Trp Phe Lys Ala Ser
 440                 445                 450                 455

 ttt ggg agc aca cga ggc tac cat ggc tgc agc aag aag gcc ctg gtc     1444
 Phe Gly Ser Thr Arg Gly Tyr His Gly Cys Ser Lys Lys Ala Leu Val
                 460                 465                 470

 ttc ctg ttt acg ttc ttg tca gaa ctc gtg cct ttt gag tct ccc cgg     1492
 Phe Leu Phe Thr Phe Leu Ser Glu Leu Val Pro Phe Glu Ser Pro Arg
             475                 480                 485

 tac ctg cag gtg cac att ctc cac cca ccc ctg gtt ccc agc aag tac     1540
 Tyr Leu Gln Val His Ile Leu His Pro Pro Leu Val Pro Ser Lys Tyr
         490                 495                 500

 cgc tcc ctc ctc aca gac tac atc tca ttg gcc aag aca cgg ctg gcc     1588
 Arg Ser Leu Leu Thr Asp Tyr Ile Ser Leu Ala Lys Thr Arg Leu Ala
     505                 510                 515

 gac ctc aag gtt tct ata gaa aac atg gga ctc tac gag gat ttg tca     1636
 Asp Leu Lys Val Ser Ile Glu Asn Met Gly Leu Tyr Glu Asp Leu Ser
 520                 525                 530                 535

 tca gct ggg gac att act gag ccc cac agc caa gct ctt cag gat gtt     1684
 Ser Ala Gly Asp Ile Thr Glu Pro His Ser Gln Ala Leu Gln Asp Val
                 540                 545                 550

 gaa aag gcc atc atg gtg ttt gag cat acg ggg aac atc cca gtc acc     1732
 Glu Lys Ala Ile Met Val Phe Glu His Thr Gly Asn Ile Pro Val Thr
             555                 560                 565

 gtc atg gag gcc agc ata ttc agg agg cct tac tac gtg tcc cac ttc     1780
 Val Met Glu Ala Ser Ile Phe Arg Arg Pro Tyr Tyr Val Ser His Phe
         570                 575                 580

 ctc ccc gcc ctg ctc aca cct cga gtg ctc ccc aaa gtc cct gac tcc     1828
 Leu Pro Ala Leu Leu Thr Pro Arg Val Leu Pro Lys Val Pro Asp Ser
     585                 590                 595

 cgt gtg gcg ttt ata gag tct ctg aag aga gca gat aaa atc ccc cca     1876
 Arg Val Ala Phe Ile Glu Ser Leu Lys Arg Ala Asp Lys Ile Pro Pro
 600                 605                 610                 615

 tct ctg tac tcc acc tac tgc cag gcc tgc tct gct gct gaa gag aag     1924
 Ser Leu Tyr Ser Thr Tyr Cys Gln Ala Cys Ser Ala Ala Glu Glu Lys
                 620                 625                 630

 cca gaa gat gca gcc ctg gga gtg agg gca gaa ccc aac tct gct gag     1972
 Pro Glu Asp Ala Ala Leu Gly Val Arg Ala Glu Pro Asn Ser Ala Glu
             635                 640                 645

 gag ccc ctg gga cag ctc aca gct gca ctg gga gag ctg aga gcc tcc     2020
 Glu Pro Leu Gly Gln Leu Thr Ala Ala Leu Gly Glu Leu Arg Ala Ser
         650                 655                 660

 atg aca gac ccc agc cag cgt gat gtt ata tcg gca cag gtg gca gtg     2068
 Met Thr Asp Pro Ser Gln Arg Asp Val Ile Ser Ala Gln Val Ala Val
     665                 670                 675

 att tct gaa aga ctg agg gct gtc ctg ggc cac aat gag gat gac agc     2116
 Ile Ser Glu Arg Leu Arg Ala Val Leu Gly His Asn Glu Asp Asp Ser
 680                 685                 690                 695

 agc gtt gag ata tca aag att cag ctc agc atc aac acg ccg aga ctg     2164
 Ser Val Glu Ile Ser Lys Ile Gln Leu Ser Ile Asn Thr Pro Arg Leu
                 700                 705                 710

 gag cca cgg gaa cac att gct gtg gac ctc ctg ctg acg tct ttc tgt     2212
 Glu Pro Arg Glu His Ile Ala Val Asp Leu Leu Leu Thr Ser Phe Cys
             715                 720                 725

 cag aac ctg atg gct gcc tcc agt gtc gct ccc ccg gag agg cag ggt     2260
 Gln Asn Leu Met Ala Ala Ser Ser Val Ala Pro Pro Glu Arg Gln Gly
         730                 735                 740

 ccc tgg gct gcc ctc ttc gtg agg acc atg tgt gga cgt gtg ctc cct     2308
 Pro Trp Ala Ala Leu Phe Val Arg Thr Met Cys Gly Arg Val Leu Pro
     745                 750                 755

 gca gtg ctc acc cgg ctc tgc cag ctg ctc cgt cac cag ggc ccg agc     2356
 Ala Val Leu Thr Arg Leu Cys Gln Leu Leu Arg His Gln Gly Pro Ser
 760                 765                 770                 775

 ctg agt gcc cca cat gtg ctg ggg ttg gct gcc ctg gcc gtg cac ctg     2404
 Leu Ser Ala Pro His Val Leu Gly Leu Ala Ala Leu Ala Val His Leu
                 780                 785                 790

 ggt gag tcc agg tct gcg ctc cca gag gtg gat gtg ggt cct cct gca     2452
 Gly Glu Ser Arg Ser Ala Leu Pro Glu Val Asp Val Gly Pro Pro Ala
             795                 800                 805

 cct ggt gct ggc ctt cct gtc cct gcg ctc ttt gac agc ctc ctg acc     2500
 Pro Gly Ala Gly Leu Pro Val Pro Ala Leu Phe Asp Ser Leu Leu Thr
         810                 815                 820

 tgt agg acg agg gat tcc ttg ttc ttc tgc ctg aaa ttt tgt aca gca     2548
 Cys Arg Thr Arg Asp Ser Leu Phe Phe Cys Leu Lys Phe Cys Thr Ala
     825                 830                 835

 gca att tct tac tct ctc tgc aag ttt tct tcc cag tca cga gat act     2596
 Ala Ile Ser Tyr Ser Leu Cys Lys Phe Ser Ser Gln Ser Arg Asp Thr
 840                 845                 850                 855

 ttg tgc agc tgc tta tct cca ggc ctt att aaa aag ttt cag ttc ctc     2644
 Leu Cys Ser Cys Leu Ser Pro Gly Leu Ile Lys Lys Phe Gln Phe Leu
                 860                 865                 870

 atg ttc aga ttg ttc tca gag gcc cga cag cct ctt tct gag gag gac     2692
 Met Phe Arg Leu Phe Ser Glu Ala Arg Gln Pro Leu Ser Glu Glu Asp
             875                 880                 885

 gta gcc agc ctt tcc tgg aga ccc ttg cac ctt cct tct gca gac tgg     2740
 Val Ala Ser Leu Ser Trp Arg Pro Leu His Leu Pro Ser Ala Asp Trp
         890                 895                 900

 cag aga gct gcc ctc tct ctc tgg aca cac aga acc ttc cga gag gtg     2788
 Gln Arg Ala Ala Leu Ser Leu Trp Thr His Arg Thr Phe Arg Glu Val
     905                 910                 915

 ttg aaa gag gaa gat gtt cac tta act tac caa gac tgg tta cac ctg     2836
 Leu Lys Glu Glu Asp Val His Leu Thr Tyr Gln Asp Trp Leu His Leu
 920                 925                 930                 935

 gag ctg gaa att caa cct gaa gct gat gct ctt tca gat act gaa cgg     2884
 Glu Leu Glu Ile Gln Pro Glu Ala Asp Ala Leu Ser Asp Thr Glu Arg
                 940                 945                 950

 cag gac ttc cac cag tgg gcg atc cat gag cac ttt ctc cct gag tcc     2932
 Gln Asp Phe His Gln Trp Ala Ile His Glu His Phe Leu Pro Glu Ser
             955                 960                 965

 tcg gct tca ggg ggc tgt gac gga gac ctg cag gct gcg tgt acc att     2980
 Ser Ala Ser Gly Gly Cys Asp Gly Asp Leu Gln Ala Ala Cys Thr Ile
         970                 975                 980

 ctt gtc aac gca ctg atg gat ttc cac caa agc tca agg agt tat gac     3028
 Leu Val Asn Ala Leu Met Asp Phe His Gln Ser Ser Arg Ser Tyr Asp
     985                 990                 995

 cac tca gaa aat tct gat ttg gtc ttt ggt ggc cgc aca gga aat gag     3076
 His Ser Glu Asn Ser Asp Leu Val Phe Gly Gly Arg Thr Gly Asn Glu
1000                1005                1010                1015

 gat att att tcc aga ttg cag gag atg gta gct gac ctg gag ctg cag     3124
 Asp Ile Ile Ser Arg Leu Gln Glu Met Val Ala Asp Leu Glu Leu Gln
                1020                1025                1030

 caa gac ctc ata gtg cct ctc ggc cac acc cct tcc cag gag cac ttc     3172
 Gln Asp Leu Ile Val Pro Leu Gly His Thr Pro Ser Gln Glu His Phe
            1035                1040                1045

 ctc ttt gag att ttc cgc aga cgg ctc cag gct ctg aca agc ggg tgg     3220
 Leu Phe Glu Ile Phe Arg Arg Arg Leu Gln Ala Leu Thr Ser Gly Trp
        1050                1055                1060

 agc gtg gct gcc agc ctt cag aga cag agg gag ctg cta atg tac aaa     3268
 Ser Val Ala Ala Ser Leu Gln Arg Gln Arg Glu Leu Leu Met Tyr Lys
    1065                1070                1075

 cgg atc ctc ctc cgc ctg cct tcg tct gtc ctc tgc ggc agc agc ttc     3316
 Arg Ile Leu Leu Arg Leu Pro Ser Ser Val Leu Cys Gly Ser Ser Phe
1080                1085                1090                1095

 cag gca gaa cag ccc atc act gcc aga tgc gag cag ttc ttc cac ttg     3364
 Gln Ala Glu Gln Pro Ile Thr Ala Arg Cys Glu Gln Phe Phe His Leu
                1100                1105                1110

 gtc aac tct gag atg aga aac ttc tgc tcc cac gga ggt gcc ctg aca     3412
 Val Asn Ser Glu Met Arg Asn Phe Cys Ser His Gly Gly Ala Leu Thr
            1115                1120                1125

 cag gac atc act gcc cac ttc ttc agg ggc ctc ctg aac gcc tgt ctg     3460
 Gln Asp Ile Thr Ala His Phe Phe Arg Gly Leu Leu Asn Ala Cys Leu
        1130                1135                1140

 cgg agc aga gac ccc tcc ctg atg gtc gac ttc ata ctg gcc aag tgc     3508
 Arg Ser Arg Asp Pro Ser Leu Met Val Asp Phe Ile Leu Ala Lys Cys
    1145                1150                1155

 cag acg aaa tgc ccc tta att ttg acc tct gct ctg gtg tgg tgg ccg     3556
 Gln Thr Lys Cys Pro Leu Ile Leu Thr Ser Ala Leu Val Trp Trp Pro
1160                1165                1170                1175

 agc ctg gag cct gtg ctg ctc tgc cgg tgg agg aga cac tgc cag agc     3604
 Ser Leu Glu Pro Val Leu Leu Cys Arg Trp Arg Arg His Cys Gln Ser
                1180                1185                1190

 ccg ctg ccc cgg gaa ctg cag aag cta caa gaa ggc cgg cag ttt gcc     3652
 Pro Leu Pro Arg Glu Leu Gln Lys Leu Gln Glu Gly Arg Gln Phe Ala
            1195                1200                1205

 agc gat ttc ctc tcc cct gag gct gcc tcc cca gca ccc aac ccg gac     3700
 Ser Asp Phe Leu Ser Pro Glu Ala Ala Ser Pro Ala Pro Asn Pro Asp
        1210                1215                1220

 tgg ctc tca gct gct gca ctg cac ttt gcg att caa caa gtc agg gaa     3748
 Trp Leu Ser Ala Ala Ala Leu His Phe Ala Ile Gln Gln Val Arg Glu
    1225                1230                1235

 gaa aac atc agg aag cag cta aag aag ctg gac tgc gag aga gag gag     3796
 Glu Asn Ile Arg Lys Gln Leu Lys Lys Leu Asp Cys Glu Arg Glu Glu
1240                1245                1250                1255

 cta ttg gtt ttc ctt ttc ttc ttc tcc ttg atg ggc ctg ctg tcg tca     3844
 Leu Leu Val Phe Leu Phe Phe Phe Ser Leu Met Gly Leu Leu Ser Ser
                1260                1265                1270

 cat ctg acc tca aat agc acc aca gac ctg cca aag gct ttc cac gtt     3892
 His Leu Thr Ser Asn Ser Thr Thr Asp Leu Pro Lys Ala Phe His Val
            1275                1280                1285

 tgt gca gca atc ctc gag tgt tta gag aag agg aag ata tcc tgg ctg     3940
 Cys Ala Ala Ile Leu Glu Cys Leu Glu Lys Arg Lys Ile Ser Trp Leu
        1290                1295                1300

 gca ctc ttt cag ttg aca gag agt gac ctc agg ctg ggg cgg ctc ctc     3988
 Ala Leu Phe Gln Leu Thr Glu Ser Asp Leu Arg Leu Gly Arg Leu Leu
    1305                1310                1315

 ctc cgt gtg gcc ccg gat cag cac acc agg ctg ctg cct ttc gct ttt     4036
 Leu Arg Val Ala Pro Asp Gln His Thr Arg Leu Leu Pro Phe Ala Phe
1320                1325                1330                1335

 tac agt ctt ctc tcc tac ttc cat gaa gac gcg gcc atc agg gaa gag     4084
 Tyr Ser Leu Leu Ser Tyr Phe His Glu Asp Ala Ala Ile Arg Glu Glu
                1340                1345                1350

 gcc ttc ctg cat gtt gct gtg gac atg tac ttg aag ctg gtc cag ctc     4132
 Ala Phe Leu His Val Ala Val Asp Met Tyr Leu Lys Leu Val Gln Leu
            1355                1360                1365

 ttc gtg gct ggg gat aca agc aca gtt tca cct cca gct ggc agg agc     4180
 Phe Val Ala Gly Asp Thr Ser Thr Val Ser Pro Pro Ala Gly Arg Ser
        1370                1375                1380

 ctg gag ctc aag ggt cag gca ggg caa ccc cgt gga act gat aac aaa     4228
 Leu Glu Leu Lys Gly Gln Ala Gly Gln Pro Arg Gly Thr Asp Asn Lys
    1385                1390                1395

 agc tcg tct ttt tct gct gca gtt aat acc tcg gtg ccc gaa aaa gag     4276
 Ser Ser Ser Phe Ser Ala Ala Val Asn Thr Ser Val Pro Glu Lys Glu
1400                1405                1410                1415

 ctt ctc aca cgt ggc aga gct gct ggc tga t cgtggggact gcgacccaga     4327
 Leu Leu Thr Arg Gly Arg Ala Ala Gly 
                1420

 ggtgagcgcc gccctccaga gcagacagca ggctgcccct gacgctgacc tgtcccagga   4387

 gcctcatctc ttctgacggg acctgccact gcacaccagc ccagctcccg tgtaaataat   4447

 ttattacaag cataacatgg agctcttgtt gcactaaaaa gtggattaca aatctcctcg   4507

 actgctttag tggggaaagg aatcaattat ttatgaactg tccggccccg agtcactcag   4567

 cgtttgcggg aaaataaacc actggtccca gagcagagga aggctacttg agccggacac   4627

 caagcccgcc tccagcacca agggcgggca gcaccctccg accctcccat gcgggtgcac   4687

 acgaagggtg aggctgacac agccactgcg gagtccaggc tgctagaggt gctcatcctc   4747

 actgccgtcc tcaggtgggt tcgggcttca ccgcctggcc ctctgtggtc acagaggggc   4807

 tcggtggccc aggtggtggt tccgcctcca ggggcagggc cttgtcctgg gtctgtgtca   4867

 gcgggtgcac catggacatg tgtacattga ggttgtgggc cttctcaaac cgccggccac   4927

 actggtcaca ggcaaagtcc agctcagtct cagccttgtg tttggtcatg tggtacttga   4987

 gggatgcccg ctgcctgcac tggaacccac agacctcaca cctgggggac agaggcagat   5047

 aagaaggtgc gagggccaca gccctgggag ggggtcctga ctcacactta ctgcaaaggc   5107

 ttggctcccg aatgtcgcat ttggtggacg agaaggtgct tccgctgctt gaaggtttgt   5167

 ccacattcgt cacagatata gttccgcacc tctgagaggg gagagtccag tgagtccagg   5227

 cccctgatgc tccaacctcc cggggggacg acgatgacaa tgtgaaacca tcacagctgg   5287

 gaagacattt ctgcacatgg ttcaccatgc agtgggccca agcaaggggc ctatgagggc   5347

 ctcgtttatt aagatcttta aactgcttta tacactgtca cgtggcttca tcagctgtgt   5407

 gcatttcagg atggttttta aagaaacctc agaaagctat ttccttaaaa aaaaaaaaa    5466




      <210> 62
      <211> 5336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(4177)

      <400> 62
 agccgccgcc ggggctgtag gcgccaaggc c   atg tcc gac tcg tgg gtc ccg      52
                                      Met Ser Asp Ser Trp Val Pro
                                        1               5

 aac tcc gcc tcg ggc cag gac cca ggg ggc cgc cgg agg gcc tgg gcc      100
 Asn Ser Ala Ser Gly Gln Asp Pro Gly Gly Arg Arg Arg Ala Trp Ala
          10                  15                  20

 gag ctg ctg gcg gga agg gtc aag agg gaa aaa tat aat cct gaa agg      148
 Glu Leu Leu Ala Gly Arg Val Lys Arg Glu Lys Tyr Asn Pro Glu Arg
      25                  30                  35

 gca cag aaa tta aag gaa tca gct gtg cgc ctc ctg cga agc cat cag      196
 Ala Gln Lys Leu Lys Glu Ser Ala Val Arg Leu Leu Arg Ser His Gln
  40                  45                  50                  55

 gac ctg aat gcc ctt ttg ctt gag gta gaa ggt cca ctg tgt aaa aaa      244
 Asp Leu Asn Ala Leu Leu Leu Glu Val Glu Gly Pro Leu Cys Lys Lys
                  60                  65                  70

 ttg tct ctc agc aaa gtg att gac tgt gac agt tct gag gcc tat gct      292
 Leu Ser Leu Ser Lys Val Ile Asp Cys Asp Ser Ser Glu Ala Tyr Ala
              75                  80                  85

 aat cat tct agt tca ttt ata ggc tct gct ttg cag gat caa gcc tca      340
 Asn His Ser Ser Ser Phe Ile Gly Ser Ala Leu Gln Asp Gln Ala Ser
          90                  95                 100

 agg ctg ggg gtt ccc gtg ggt att ctc tca gcc ggg atg gtt gcc tct      388
 Arg Leu Gly Val Pro Val Gly Ile Leu Ser Ala Gly Met Val Ala Ser
     105                 110                 115

 agc gtg gga cag atc tgc acg gct cca gcg gag acc agt cac cct gtg      436
 Ser Val Gly Gln Ile Cys Thr Ala Pro Ala Glu Thr Ser His Pro Val
 120                 125                 130                 135

 ctg ctg act gtg gag cag aga aag aag ctg tct tcc ctg tta gag ttt      484
 Leu Leu Thr Val Glu Gln Arg Lys Lys Leu Ser Ser Leu Leu Glu Phe
                 140                 145                 150

 gct cag tat tta ttg gca cac agt atg ttc tcc cgt ctt tcc ttc tgt      532
 Ala Gln Tyr Leu Leu Ala His Ser Met Phe Ser Arg Leu Ser Phe Cys
             155                 160                 165

 caa gaa tta tgg aaa ata cag agt tct ttg ttg ctt gaa gcg gtg tgg      580
 Gln Glu Leu Trp Lys Ile Gln Ser Ser Leu Leu Leu Glu Ala Val Trp
         170                 175                 180

 cat ctt cac gta caa ggc att gtg agc ctg caa gag ctg ctg gaa agc      628
 His Leu His Val Gln Gly Ile Val Ser Leu Gln Glu Leu Leu Glu Ser
     185                 190                 195

 cat ccc gac atg cat gct gtg gga tcg tgg ctc ttc agg aat ctg tgc      676
 His Pro Asp Met His Ala Val Gly Ser Trp Leu Phe Arg Asn Leu Cys
 200                 205                 210                 215

 tgc ctt tgt gaa cag atg gaa gca tcc tgc cag cat gct gac gtc gcc      724
 Cys Leu Cys Glu Gln Met Glu Ala Ser Cys Gln His Ala Asp Val Ala
                 220                 225                 230

 agg gcc atg ctt tct gat ttt gtt caa atg ttt gtt ttg agg gga ttt      772
 Arg Ala Met Leu Ser Asp Phe Val Gln Met Phe Val Leu Arg Gly Phe
             235                 240                 245

 cag aaa aac tca gat ctg aga aga act gtg gag cct gaa aaa atg ccg      820
 Gln Lys Asn Ser Asp Leu Arg Arg Thr Val Glu Pro Glu Lys Met Pro
         250                 255                 260

 cag gtc acg gtt gat gta ctg cag aga atg ctg att ttt gca ctt gac      868
 Gln Val Thr Val Asp Val Leu Gln Arg Met Leu Ile Phe Ala Leu Asp
     265                 270                 275

 gct ttg gct gct gga gta cag gag gag tcc tcc act cac aag atc gtg      916
 Ala Leu Ala Ala Gly Val Gln Glu Glu Ser Ser Thr His Lys Ile Val
 280                 285                 290                 295

 agg tgc tgg ttc gga gtg ttc agt gga cac acg ctt ggc agt gta att      964
 Arg Cys Trp Phe Gly Val Phe Ser Gly His Thr Leu Gly Ser Val Ile
                 300                 305                 310

 tcc aca gat cct ctg aag agg ttc ttc agt cat acc ctg act cag ata     1012
 Ser Thr Asp Pro Leu Lys Arg Phe Phe Ser His Thr Leu Thr Gln Ile
             315                 320                 325

 ctc act cac agc cct gtg ctg aaa gca tct gat gct gtt cag atg cag     1060
 Leu Thr His Ser Pro Val Leu Lys Ala Ser Asp Ala Val Gln Met Gln
         330                 335                 340

 aga gag tgg agc ttt gcg cgg aca cac cct ctg ctc acc tca ctg tac     1108
 Arg Glu Trp Ser Phe Ala Arg Thr His Pro Leu Leu Thr Ser Leu Tyr
     345                 350                 355

 cgc agg ctc ttt gtg atg ctg agt gca gag gag ttg gtt ggc cat ttg     1156
 Arg Arg Leu Phe Val Met Leu Ser Ala Glu Glu Leu Val Gly His Leu
 360                 365                 370                 375

 caa gaa gtt ctg gaa acg cag gag gtt cac tgg cag aga gtg ctc tcc     1204
 Gln Glu Val Leu Glu Thr Gln Glu Val His Trp Gln Arg Val Leu Ser
                 380                 385                 390

 ttt gtg tct gcc ctg gtt gtc tgc ttt cca gaa gcg cag cag ctg ctt     1252
 Phe Val Ser Ala Leu Val Val Cys Phe Pro Glu Ala Gln Gln Leu Leu
             395                 400                 405

 gaa gac tgg gtg gcg cgt ttg atg gcc cag gca ttc gag agc tgc cag     1300
 Glu Asp Trp Val Ala Arg Leu Met Ala Gln Ala Phe Glu Ser Cys Gln
         410                 415                 420

 ctg gac agc atg gtc act gcg ttc ctg gtt gtg cgc cag gca gca ctg     1348
 Leu Asp Ser Met Val Thr Ala Phe Leu Val Val Arg Gln Ala Ala Leu
     425                 430                 435

 gag ggc ccc tct gcg ttc ctg tca tat gca gac tgg ttc aag gcc tcc     1396
 Glu Gly Pro Ser Ala Phe Leu Ser Tyr Ala Asp Trp Phe Lys Ala Ser
 440                 445                 450                 455

 ttt ggg agc aca cga ggc tac cat ggc tgc agc aag aag gcc ctg gtc     1444
 Phe Gly Ser Thr Arg Gly Tyr His Gly Cys Ser Lys Lys Ala Leu Val
                 460                 465                 470

 ttc ctg ttt acg ttc ttg tca gaa ctc gtg cct ttt gag tct ccc cgg     1492
 Phe Leu Phe Thr Phe Leu Ser Glu Leu Val Pro Phe Glu Ser Pro Arg
             475                 480                 485

 tac ctg cag gtg cac att ctc cac cca ccc ctg gtt ccc agc aag tac     1540
 Tyr Leu Gln Val His Ile Leu His Pro Pro Leu Val Pro Ser Lys Tyr
         490                 495                 500

 cgc tcc ctc ctc aca gac tac atc tca ttg gcc aag aca cgg ctg gcc     1588
 Arg Ser Leu Leu Thr Asp Tyr Ile Ser Leu Ala Lys Thr Arg Leu Ala
     505                 510                 515

 gac ctc aag gtt tct ata gaa aac atg gga ctc tac gag gat ttg tca     1636
 Asp Leu Lys Val Ser Ile Glu Asn Met Gly Leu Tyr Glu Asp Leu Ser
 520                 525                 530                 535

 tca gct ggg gac att act gag ccc cac agc caa gct ctt cag gat gtt     1684
 Ser Ala Gly Asp Ile Thr Glu Pro His Ser Gln Ala Leu Gln Asp Val
                 540                 545                 550

 gaa aag gcc atc atg gtg ttt gag cat acg ggg aac atc cca gtc acc     1732
 Glu Lys Ala Ile Met Val Phe Glu His Thr Gly Asn Ile Pro Val Thr
             555                 560                 565

 gtc atg gag gcc agc ata ttc agg agg cct tac tac gtg tcc cac ttc     1780
 Val Met Glu Ala Ser Ile Phe Arg Arg Pro Tyr Tyr Val Ser His Phe
         570                 575                 580

 ctc ccc gcc ctg ctc aca cct cga gtg ctc ccc aaa gtc cct gac tcc     1828
 Leu Pro Ala Leu Leu Thr Pro Arg Val Leu Pro Lys Val Pro Asp Ser
     585                 590                 595

 cgt gtg gcg ttt ata gag tct ctg aag aga gca gat aaa atc ccc cca     1876
 Arg Val Ala Phe Ile Glu Ser Leu Lys Arg Ala Asp Lys Ile Pro Pro
 600                 605                 610                 615

 tct ctg tac tcc acc tac tgc cag gcc tgc tct gct gct gaa gag aag     1924
 Ser Leu Tyr Ser Thr Tyr Cys Gln Ala Cys Ser Ala Ala Glu Glu Lys
                 620                 625                 630

 cca gaa gat gca gcc ctg gga gtg agg gca gaa ccc aac tct gct gag     1972
 Pro Glu Asp Ala Ala Leu Gly Val Arg Ala Glu Pro Asn Ser Ala Glu
             635                 640                 645

 gag ccc ctg gga cag ctc aca gct gca ctg gga gag ctg aga gcc tcc     2020
 Glu Pro Leu Gly Gln Leu Thr Ala Ala Leu Gly Glu Leu Arg Ala Ser
         650                 655                 660

 atg aca gac ccc agc cag cgt gat gtt ata tcg gca cag gtg gca gtg     2068
 Met Thr Asp Pro Ser Gln Arg Asp Val Ile Ser Ala Gln Val Ala Val
     665                 670                 675

 att tct gaa aga ctg agg gct gtc ctg ggc cac aat gag gat gac agc     2116
 Ile Ser Glu Arg Leu Arg Ala Val Leu Gly His Asn Glu Asp Asp Ser
 680                 685                 690                 695

 agc gtt gag ata tca aag att cag ctc agc atc aac acg ccg aga ctg     2164
 Ser Val Glu Ile Ser Lys Ile Gln Leu Ser Ile Asn Thr Pro Arg Leu
                 700                 705                 710

 gag cca cgg gaa cac att gct gtg gac ctc ctg ctg acg tct ttc tgt     2212
 Glu Pro Arg Glu His Ile Ala Val Asp Leu Leu Leu Thr Ser Phe Cys
             715                 720                 725

 cag aac ctg atg gct gcc tcc agt gtc gct ccc ccg gag agg cag ggt     2260
 Gln Asn Leu Met Ala Ala Ser Ser Val Ala Pro Pro Glu Arg Gln Gly
         730                 735                 740

 ccc tgg gct gcc ctc ttc gtg agg acc atg tgt gga cgt gtg ctc cct     2308
 Pro Trp Ala Ala Leu Phe Val Arg Thr Met Cys Gly Arg Val Leu Pro
     745                 750                 755

 gca gtg ctc acc cgg ctc tgc cag ctg ctc cgt cac cag ggc ccg agc     2356
 Ala Val Leu Thr Arg Leu Cys Gln Leu Leu Arg His Gln Gly Pro Ser
 760                 765                 770                 775

 ctg agt gcc cca cat gtg ctg ggg ttg gct gcc ctg gcc gtg cac ctg     2404
 Leu Ser Ala Pro His Val Leu Gly Leu Ala Ala Leu Ala Val His Leu
                 780                 785                 790

 ggt gag tcc agg tct gcg ctc cca gag gtg gat gtg ggt cct cct gca     2452
 Gly Glu Ser Arg Ser Ala Leu Pro Glu Val Asp Val Gly Pro Pro Ala
             795                 800                 805

 cct ggt gct ggc ctt cct gtc cct gcg ctc ttt gac agc ctc ctg acc     2500
 Pro Gly Ala Gly Leu Pro Val Pro Ala Leu Phe Asp Ser Leu Leu Thr
         810                 815                 820

 tgt agg acg agg gat tcc ttg ttc ttc tgc ctg aaa ttt tgt aca gca     2548
 Cys Arg Thr Arg Asp Ser Leu Phe Phe Cys Leu Lys Phe Cys Thr Ala
     825                 830                 835

 gca att tct tac tct ctc tgc aag ttt tct tcc cag tca cga gat act     2596
 Ala Ile Ser Tyr Ser Leu Cys Lys Phe Ser Ser Gln Ser Arg Asp Thr
 840                 845                 850                 855

 ttg tgc agc tgc tta tct cca ggc ctt att aaa aag ttt cag ttc ctc     2644
 Leu Cys Ser Cys Leu Ser Pro Gly Leu Ile Lys Lys Phe Gln Phe Leu
                 860                 865                 870

 atg ttc aga ttg ttc tca gag gcc cga cag cct ctt tct gag gag gac     2692
 Met Phe Arg Leu Phe Ser Glu Ala Arg Gln Pro Leu Ser Glu Glu Asp
             875                 880                 885

 gta gcc agc ctt tcc tgg aga ccc ttg cac ctt cct tct gca gac tgg     2740
 Val Ala Ser Leu Ser Trp Arg Pro Leu His Leu Pro Ser Ala Asp Trp
         890                 895                 900

 cag aga gct gcc ctc tct ctc tgg aca cac aga acc ttc cga gag gtg     2788
 Gln Arg Ala Ala Leu Ser Leu Trp Thr His Arg Thr Phe Arg Glu Val
     905                 910                 915

 ttg aaa gag gaa gat gtt cac tta act tac caa gac tgg tta cac ctg     2836
 Leu Lys Glu Glu Asp Val His Leu Thr Tyr Gln Asp Trp Leu His Leu
 920                 925                 930                 935

 gag ctg gaa att caa cct gaa gct gat gct ctt tca gat act gaa cgg     2884
 Glu Leu Glu Ile Gln Pro Glu Ala Asp Ala Leu Ser Asp Thr Glu Arg
                 940                 945                 950

 tca agg agt tat gac cac tca gaa aat tct gat ttg gtc ttt ggt ggc     2932
 Ser Arg Ser Tyr Asp His Ser Glu Asn Ser Asp Leu Val Phe Gly Gly
             955                 960                 965

 cgc aca gga aat gag gat att att tcc aga ttg cag gag atg gta gct     2980
 Arg Thr Gly Asn Glu Asp Ile Ile Ser Arg Leu Gln Glu Met Val Ala
         970                 975                 980

 gac ctg gag ctg cag caa gac ctc ata gtg cct ctc ggc cac acc cct     3028
 Asp Leu Glu Leu Gln Gln Asp Leu Ile Val Pro Leu Gly His Thr Pro
     985                 990                 995

 tcc cag gag cac ttc ctc ttt gag att ttc cgc aga cgg ctc cag gct     3076
 Ser Gln Glu His Phe Leu Phe Glu Ile Phe Arg Arg Arg Leu Gln Ala
1000                1005                1010                1015

 ctg aca agc ggg tgg agc gtg gct gcc agc ctt cag aga cag agg gag     3124
 Leu Thr Ser Gly Trp Ser Val Ala Ala Ser Leu Gln Arg Gln Arg Glu
                1020                1025                1030

 ctg cta atg tac aaa cgg atc ctc ctc cgc ctg cct tcg tct gtc ctc     3172
 Leu Leu Met Tyr Lys Arg Ile Leu Leu Arg Leu Pro Ser Ser Val Leu
            1035                1040                1045

 tgc ggc agc agc ttc cag gca gaa cag ccc atc act gcc aga tgc gag     3220
 Cys Gly Ser Ser Phe Gln Ala Glu Gln Pro Ile Thr Ala Arg Cys Glu
        1050                1055                1060

 cag ttc ttc cac ttg gtc aac tct gag atg aga aac ttc tgc tcc cac     3268
 Gln Phe Phe His Leu Val Asn Ser Glu Met Arg Asn Phe Cys Ser His
    1065                1070                1075

 gga ggt gcc ctg aca cag gac atc act gcc cac ttc ttc agg ggc ctc     3316
 Gly Gly Ala Leu Thr Gln Asp Ile Thr Ala His Phe Phe Arg Gly Leu
1080                1085                1090                1095

 ctg aac gcc tgt ctg cgg agc aga gac ccc tcc ctg atg gtc gac ttc     3364
 Leu Asn Ala Cys Leu Arg Ser Arg Asp Pro Ser Leu Met Val Asp Phe
                1100                1105                1110

 ata ctg gcc aag tgc cag acg aaa tgc ccc tta att ttg acc tct gct     3412
 Ile Leu Ala Lys Cys Gln Thr Lys Cys Pro Leu Ile Leu Thr Ser Ala
            1115                1120                1125

 ctg gtg tgg tgg ccg agc ctg gag cct gtg ctg ctc tgc cgg tgg agg     3460
 Leu Val Trp Trp Pro Ser Leu Glu Pro Val Leu Leu Cys Arg Trp Arg
        1130                1135                1140

 aga cac tgc cag agc ccg ctg ccc cgg gaa ctg cag aag cta caa gaa     3508
 Arg His Cys Gln Ser Pro Leu Pro Arg Glu Leu Gln Lys Leu Gln Glu
    1145                1150                1155

 ggc cgg cag ttt gcc agc gat ttc ctc tcc cct gag gct gcc tcc cca     3556
 Gly Arg Gln Phe Ala Ser Asp Phe Leu Ser Pro Glu Ala Ala Ser Pro
1160                1165                1170                1175

 gca ccc aac ccg gac tgg ctc tca gct gct gca ctg cac ttt gcg att     3604
 Ala Pro Asn Pro Asp Trp Leu Ser Ala Ala Ala Leu His Phe Ala Ile
                1180                1185                1190

 caa caa gtc agg gaa gaa aac atc agg aag cag cta aag aag ctg gac     3652
 Gln Gln Val Arg Glu Glu Asn Ile Arg Lys Gln Leu Lys Lys Leu Asp
            1195                1200                1205

 tgc gag aga gag gag cta ttg gtt ttc ctt ttc ttc ttc tcc ttg atg     3700
 Cys Glu Arg Glu Glu Leu Leu Val Phe Leu Phe Phe Phe Ser Leu Met
        1210                1215                1220

 ggc ctg ctg tcg tca cat ctg acc tca aat agc acc aca gac ctg cca     3748
 Gly Leu Leu Ser Ser His Leu Thr Ser Asn Ser Thr Thr Asp Leu Pro
    1225                1230                1235

 aag gct ttc cac gtt tgt gca gca atc ctc gag tgt tta gag aag agg     3796
 Lys Ala Phe His Val Cys Ala Ala Ile Leu Glu Cys Leu Glu Lys Arg
1240                1245                1250                1255

 aag ata tcc tgg ctg gca ctc ttt cag ttg aca gag agt gac ctc agg     3844
 Lys Ile Ser Trp Leu Ala Leu Phe Gln Leu Thr Glu Ser Asp Leu Arg
                1260                1265                1270

 ctg ggg cgg ctc ctc ctc cgt gtg gcc ccg gat cag cac acc agg ctg     3892
 Leu Gly Arg Leu Leu Leu Arg Val Ala Pro Asp Gln His Thr Arg Leu
            1275                1280                1285

 ctg cct ttc gct ttt tac agt ctt ctc tcc tac ttc cat gaa gac gcg     3940
 Leu Pro Phe Ala Phe Tyr Ser Leu Leu Ser Tyr Phe His Glu Asp Ala
        1290                1295                1300

 gcc atc agg gaa gag gcc ttc ctg cat gtt gct gtg gac atg tac ttg     3988
 Ala Ile Arg Glu Glu Ala Phe Leu His Val Ala Val Asp Met Tyr Leu
    1305                1310                1315

 aag ctg gtc cag ctc ttc gtg gct ggg gat aca agc aca gtt tca cct     4036
 Lys Leu Val Gln Leu Phe Val Ala Gly Asp Thr Ser Thr Val Ser Pro
1320                1325                1330                1335

 cca gct ggc agg agc ctg gag ctc aag ggt cag gca ggg caa ccc cgt     4084
 Pro Ala Gly Arg Ser Leu Glu Leu Lys Gly Gln Ala Gly Gln Pro Arg
                1340                1345                1350

 gga act gat aac aaa agc tcg tct ttt tct gct gca gtt aat acc tcg     4132
 Gly Thr Asp Asn Lys Ser Ser Ser Phe Ser Ala Ala Val Asn Thr Ser
            1355                1360                1365

 gtg ccc gaa aaa gag ctt ctc aca cgt ggc aga gct gct ggc tga tcg     4180
 Val Pro Glu Lys Glu Leu Leu Thr Arg Gly Arg Ala Ala Gly 
        1370                1375                1380

 tggggactgc gacccagagg tgagcgccgc cctccagagc agacagcagg ctgcccctga   4240

 cgctgacctg tcccaggagc ctcatctctt ctgacgggac ctgccactgc acaccagccc   4300

 agctcccgtg taaataattt attacaagca taacatggag ctcttgttgc actaaaaagt   4360

 ggattacaaa tctcctcgac tgctttagtg gggaaaggaa tcaattattt atgaactgtc   4420

 cggccccgag tcactcagcg tttgcgggaa aataaaccac tggtcccaga gcagaggaag   4480

 gctacttgag ccggacacca agcccgcctc cagcaccaag ggcgggcagc accctccgac   4540

 cctcccatgc gggtgcacac gaagggtgag gctgacacag ccactgcgga gtccaggctg   4600

 ctagaggtgc tcatcctcac tgccgtcctc aggtgggttc gggcttcacc gcctggccct   4660

 ctgtggtcac agaggggctc ggtggcccag gtggtggttc cgcctccagg ggcagggcct   4720

 tgtcctgggt ctgtgtcagc gggtgcacca tggacatgtg tacattgagg ttgtgggcct   4780

 tctcaaaccg ccggccacac tggtcacagg caaagtccag ctcagtctca gccttgtgtt   4840

 tggtcatgtg gtacttgagg gatgcccgct gcctgcactg gaacccacag acctcacacc   4900

 tgggggacag aggcagataa gaaggtgcga gggccacagc cctgggaggg ggtcctgact   4960

 cacacttact gcaaaggctt ggctcccgaa tgtcgcattt ggtggacgag aaggtgcttc   5020

 cgctgcttga aggtttgtcc acattcgtca cagatatagt tccgcacctc tgagagggga   5080

 gagtccagtg agtccaggcc cctgatgctc caacctcccg gggggacgac gatgacaatg   5140

 tgaaaccatc acagctggga agacatttct gcacatggtt caccatgcag tgggcccaag   5200

 caaggggcct atgagggcct cgtttattaa gatctttaaa ctgctttata cactgtcacg   5260

 tggcttcatc agctgtgtgc atttcaggat ggtttttaaa gaaacctcag aaagctattt   5320

 ccttaaaaaa aaaaaa                                                   5336




      <210> 63
      <211> 1056
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(644)

      <400> 63
 gcacgaggag ctgagtgtgc gagcgccagg ggttccagct gcacgtccca ggctctccag     60

 cgcgcggcag gccggggcgg gacgaggaga gctgcgggga caacgcctgt ggctgggtcc    120

 ggagtcccgg gtgcggcgcg ggacaagcgg gcagc   atg ctc agg gcg gtc ggg     173
                                          Met Leu Arg Ala Val Gly
                                            1               5

 agc cta ctg cgc ctt ggc cgc ggg cta aca gtc cgc tgc ggc ccc ggg      221
 Ser Leu Leu Arg Leu Gly Arg Gly Leu Thr Val Arg Cys Gly Pro Gly
              10                  15                  20

 gcg cct ctc gag gcc acg cga cgg ccc gca ccg gct ctt ccg ccc cgg      269
 Ala Pro Leu Glu Ala Thr Arg Arg Pro Ala Pro Ala Leu Pro Pro Arg
          25                  30                  35

 ggt ctc ccc tgc tac tcc agc ggc ggg gcc ccc agc aat tct ggg ccc      317
 Gly Leu Pro Cys Tyr Ser Ser Gly Gly Ala Pro Ser Asn Ser Gly Pro
      40                  45                  50

 caa ggt cac ggg gag att cac cga gtc ccc acg cag cgc agg cct tcg      365
 Gln Gly His Gly Glu Ile His Arg Val Pro Thr Gln Arg Arg Pro Ser
  55                  60                  65                  70

 cag ttc gac aag aaa atc ctg ctg tgg aca ggg cgt ttc aaa tcg atg      413
 Gln Phe Asp Lys Lys Ile Leu Leu Trp Thr Gly Arg Phe Lys Ser Met
                  75                  80                  85

 gag gag atc ccg cct cgg atc ccg cca gaa atg ata gac acc gca aga      461
 Glu Glu Ile Pro Pro Arg Ile Pro Pro Glu Met Ile Asp Thr Ala Arg
              90                  95                 100

 aac aaa gct cga gtg aaa gct tgt tac ata atg att gga ctc aca att      509
 Asn Lys Ala Arg Val Lys Ala Cys Tyr Ile Met Ile Gly Leu Thr Ile
         105                 110                 115

 atc gcc tgc ttt gct gtg ata gtg tca gcc aaa agg gct gta gaa cga      557
 Ile Ala Cys Phe Ala Val Ile Val Ser Ala Lys Arg Ala Val Glu Arg
     120                 125                 130

 cat gaa tcc tta aca agt tgg aac ttg gca aag aaa gct aag tgg cgt      605
 His Glu Ser Leu Thr Ser Trp Asn Leu Ala Lys Lys Ala Lys Trp Arg
 135                 140                 145                 150

 gaa gaa gct gca ttg gct gca cag gct aaa gct aaa tga tattctaagt       654
 Glu Glu Ala Ala Leu Ala Ala Gln Ala Lys Ala Lys 
                 155                 160

 gacaaagtgt tcacctgaat accatccctg tcatcagcaa cagtagaaga tgggaaaaat    714

 agaatattta ccaaaatatc tgccatggtt ttattttggt aacaagaagc acaatgtctt    774

 ttttattttt attttttagt aaacttttac tgaagtatac catgcattca aaaagtggac    834

 aaaactgtat acagtctgat agatatttat gtcgtgaaca cctgtgtaac cactgccaaa    894

 gtgaagatgt agaatattgg caacacttca cagcctcatt cctgcctttt ctcagccatt    954

 acctcccaaa catagcagtt tttctgagtt tcatcacctt tgattcattt tgcctgtttt   1014

 tgaactttat ataaatggat ttatacatta aaaaaaaaaa aa                      1056




      <210> 64
      <211> 2461
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (530)..(1465)

      <400> 64
 aggtaccgct ccggaattcc cgggtcgacg atttcgttgg aagggaattt cagatgcgcc     60

 atgaattcct tgcctgatat tgaagaagtc aaggataaaa gcataaagaa aggaaataat    120

 gccttcaggg tctaccgaat gctgccccta tcagaacggc cttctaagaa aggaaagaaa    180

 ccaaagacag aaaaagaaga caaagttaag cacatcaagt tgtaggacag tcccatctgg    240

 acagcaacat tgagaatcaa gagattgtca ccaatccgcc agacatttgc caagttgtag    300

 aggtgaccac tgagagcgac gagcagccgg tcagcatgag cgagctctac cctctgcaga    360

 tctcccccgt gtcttcctat gcagaaagcg aaacgactga tagtgtgccc agcgatgaag    420

 agagtgccga gggacggcca cactggcgga agaggagcag ataaactcca acacgatccc    480

 ggggctcaag tggcttaaca aggaaaagaa gatttttcag atcccctgg    atg cat     535
                                                          Met His
                                                            1

 gcg gct aga cat ggg tgg gat gtg gaa aaa gat gca cca ctc ttt aga      583
 Ala Ala Arg His Gly Trp Asp Val Glu Lys Asp Ala Pro Leu Phe Arg
           5                  10                  15

 aac tgg gca atc cat aca gga aag cat caa cca gga gta gat aaa cct      631
 Asn Trp Ala Ile His Thr Gly Lys His Gln Pro Gly Val Asp Lys Pro
      20                  25                  30

 gat ccc aaa aca tgg aag gcg aat ttc aga tgc gcc atg aat tcc ttg      679
 Asp Pro Lys Thr Trp Lys Ala Asn Phe Arg Cys Ala Met Asn Ser Leu
  35                  40                  45                  50

 cct gat att gaa gaa gtc aag gat aaa agc ata aag aaa gga aat aat      727
 Pro Asp Ile Glu Glu Val Lys Asp Lys Ser Ile Lys Lys Gly Asn Asn
                  55                  60                  65

 gcc ttc agg gtc tac cga atg ctg ccc cta tca gaa cgg cct tct aag      775
 Ala Phe Arg Val Tyr Arg Met Leu Pro Leu Ser Glu Arg Pro Ser Lys
              70                  75                  80

 aaa gga aag aaa cca aag aca gaa aaa gaa gac aaa gtt aag cac atc      823
 Lys Gly Lys Lys Pro Lys Thr Glu Lys Glu Asp Lys Val Lys His Ile
          85                  90                  95

 aag caa gaa cca gtt gag tca tct ctg ggg ctt agt aat gga gta agt      871
 Lys Gln Glu Pro Val Glu Ser Ser Leu Gly Leu Ser Asn Gly Val Ser
     100                 105                 110

 gat ctt tct cct gag tat gcg gtc ctg act tca act ata aaa aat gaa      919
 Asp Leu Ser Pro Glu Tyr Ala Val Leu Thr Ser Thr Ile Lys Asn Glu
 115                 120                 125                 130

 gtg gat agt acg gtg aac atc ata gtt gta gga cag tcc cat ctg gac      967
 Val Asp Ser Thr Val Asn Ile Ile Val Val Gly Gln Ser His Leu Asp
                 135                 140                 145

 agc aac att gag aat caa gag att gtc acc aat ccg cca gac att tgc     1015
 Ser Asn Ile Glu Asn Gln Glu Ile Val Thr Asn Pro Pro Asp Ile Cys
             150                 155                 160

 caa gtt gta gag gtg acc act gag agc gac gag cag ccg gtc agc atg     1063
 Gln Val Val Glu Val Thr Thr Glu Ser Asp Glu Gln Pro Val Ser Met
         165                 170                 175

 agc gag ctc tac cct ctg cag atc tcc ccc gtg tct tcc tat gca gaa     1111
 Ser Glu Leu Tyr Pro Leu Gln Ile Ser Pro Val Ser Ser Tyr Ala Glu
     180                 185                 190

 agc gaa acg act gat agt gtg ccc agc gat gaa gag agt gcc gag gga     1159
 Ser Glu Thr Thr Asp Ser Val Pro Ser Asp Glu Glu Ser Ala Glu Gly
 195                 200                 205                 210

 cgg cca cac tgg cgg aag agg aat att gaa ggc aaa cag tac ctc agc     1207
 Arg Pro His Trp Arg Lys Arg Asn Ile Glu Gly Lys Gln Tyr Leu Ser
                 215                 220                 225

 aac atg ggg act cga ggc tcc tac ctg ctg ccc ggc atg gcg tcc ttc     1255
 Asn Met Gly Thr Arg Gly Ser Tyr Leu Leu Pro Gly Met Ala Ser Phe
             230                 235                 240

 gtc act tcc aac aaa ccg gac ctc cag gtc acc atc aaa gag gag agc     1303
 Val Thr Ser Asn Lys Pro Asp Leu Gln Val Thr Ile Lys Glu Glu Ser
         245                 250                 255

 aat ccg gtg cct tac aac agc tcc tgg ccc cct ttt caa gac ctc ccc     1351
 Asn Pro Val Pro Tyr Asn Ser Ser Trp Pro Pro Phe Gln Asp Leu Pro
     260                 265                 270

 ctt tct tcc tcc atg acc cca gca tcc agc agc agt cgg cca gac cgt     1399
 Leu Ser Ser Ser Met Thr Pro Ala Ser Ser Ser Ser Arg Pro Asp Arg
 275                 280                 285                 290

 gag acc cgg gcc agc gtc atc aag aaa aca tcg gat atc acc cag gcc     1447
 Glu Thr Arg Ala Ser Val Ile Lys Lys Thr Ser Asp Ile Thr Gln Ala
                 295                 300                 305

 cgc gtc aag agc tgt taa gcctct gactctccgc ggtggttgtt ggggcttctt     1501
 Arg Val Lys Ser Cys 
             310

 ggctttgttt tgttgtttgt ttgtatttta tttttttctc tctgacacct attttagaca   1561

 aatctaaggg aaaaagcctt gacaatagaa cattgattgc tgtgtccaac tccagtacct   1621

 ggagcttctc tttaactcag gactccagcc cattggtaga cgtgtgtttc tagagcctgc   1681

 tggatctccc agggctactc actcaagttc aaggaccaac aagggcagtg gaggtgctgc   1741

 attgcctgcg gtcaaggcca gcaaggtgga gtggatgcct cagaacggac gagataatgt   1801

 gaactagctg gaatttttta ttcttgtgaa tatgtacata ggcagcacta gcgacattgc   1861

 agtctgcttc tgcaccttat cttaaagcac ttacagatag gccttcttgt gatcttgctc   1921

 tatctcacag cacactcagc acccccttct ctgcccattc cccagcctct cttcctatcc   1981

 catcccatcc catcccatcc catcccatcc catcccgctc ttttcctact tttccttccc   2041

 tcaaagcttc cattccacat ccggaggaga agaaggaaat gaatttctct acagatgtcc   2101

 cattttcaga ctgctttaaa aaaaatcctt ctaatctgct atgcttgaat gccacgcggt   2161

 acaaaggaaa aagtatcatg gaaatattat gcaaattccc agatttgaag acaaaaatac   2221

 tctaattcta accagagcaa gcttttttat tttttataca ggggaatatt ttattcaagg   2281

 taaaattcta aataaaatat aattgttttt tatcttttct acagcaaatt tataatttta   2341

 agattccttt tcttgtttat cagcagttgt tattacatcc ttgtggcaca ttttttttta   2401

 attttgtaaa ggtgaaaaaa gcttttatga gctcatctag caatcagatt ttcctgtgga   2461




      <210> 65
      <211> 1665
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(669)

      <400> 65
 aaggatcctt aattaaatta atcccccccc ccctcc  atg aat tcc ttg cct gat      54
                                          Met Asn Ser Leu Pro Asp
                                            1               5

 att gaa gaa gtc aag gat aaa agc ata aag aaa gga aat aat gcc ttc      102
 Ile Glu Glu Val Lys Asp Lys Ser Ile Lys Lys Gly Asn Asn Ala Phe
              10                  15                  20

 agg gtc tac cga atg ctg ccc cta tca gaa cgg cct tct aag aaa gtt      150
 Arg Val Tyr Arg Met Leu Pro Leu Ser Glu Arg Pro Ser Lys Lys Val
          25                  30                  35

 gta gga cag tcc cat ctg gac agc aac att gag aat caa gag att gtc      198
 Val Gly Gln Ser His Leu Asp Ser Asn Ile Glu Asn Gln Glu Ile Val
      40                  45                  50

 acc aat ccg cca gac att tgc caa gtt gta gag gtg acc act gag agc      246
 Thr Asn Pro Pro Asp Ile Cys Gln Val Val Glu Val Thr Thr Glu Ser
  55                  60                  65                  70

 gac gag cag ccg gtc agc atg agc gag ctc tac cct ctg cag atc tcc      294
 Asp Glu Gln Pro Val Ser Met Ser Glu Leu Tyr Pro Leu Gln Ile Ser
                  75                  80                  85

 ccc gtg tct tcc tat gca gaa agc gaa acg act gat agt gtg ccc agc      342
 Pro Val Ser Ser Tyr Ala Glu Ser Glu Thr Thr Asp Ser Val Pro Ser
              90                  95                 100

 gat gaa gag agt gcc gag gga cgg cca cac tgg cgg aag agg aat att      390
 Asp Glu Glu Ser Ala Glu Gly Arg Pro His Trp Arg Lys Arg Asn Ile
         105                 110                 115

 gaa ggc aaa cag tac ctc agc aac atg ggg act cga ggc tcc tac ctg      438
 Glu Gly Lys Gln Tyr Leu Ser Asn Met Gly Thr Arg Gly Ser Tyr Leu
     120                 125                 130

 ctg ccc ggc atg gcg tcc ttc gtc act tcc aac aaa ccg gac ctc cag      486
 Leu Pro Gly Met Ala Ser Phe Val Thr Ser Asn Lys Pro Asp Leu Gln
 135                 140                 145                 150

 gtc acc atc aaa gag gag agc aat ccg gtg cct tac aac agc tcc tgg      534
 Val Thr Ile Lys Glu Glu Ser Asn Pro Val Pro Tyr Asn Ser Ser Trp
                 155                 160                 165

 ccc cct ttt caa gac ctc ccc ctt tct tcc tcc atg acc cca gca tcc      582
 Pro Pro Phe Gln Asp Leu Pro Leu Ser Ser Ser Met Thr Pro Ala Ser
             170                 175                 180

 agc agc agt cgg cca gac cgt gag acc cgg gcc agc gtc atc aag aaa      630
 Ser Ser Ser Arg Pro Asp Arg Glu Thr Arg Ala Ser Val Ile Lys Lys
         185                 190                 195

 aca tcg gat atc acc cag gcc cgc gtc aag agc tgt taa gcctctgact       679
 Thr Ser Asp Ile Thr Gln Ala Arg Val Lys Ser Cys 
     200                 205                 210

 ctccgcggtg gttgttgggg cttcttggct ttgttttgtt gtttgtttgt attttatttt    739

 tttctctctg acacctattt tagacaaatc taagggaaaa agccttgaca atagaacatt    799

 gattgctgtg tccaactcca gtacctggag cttctcttta actcaggact ccagcccatt    859

 ggtagacgtg tgtttctaga gcctgctgga tctcccaggg ctactcactc aagttcaagg    919

 accaacaagg gcagtggagg tgctgcattg cctgcggtca aggccagcaa ggtggagtgg    979

 atgcctcaga acggacgaga taatgtgaac tagctggaat tttttattct tgtgaatatg   1039

 tacataggca gcactagcga cattgcagtc tgcttctgca ccttatctta aagcacttac   1099

 agataggcct tcttgtgatc ttgctctatc tcacagcaca ctcagcaccc ccttctctgc   1159

 ccattcccca gcctctcttc ctatcccatc ccatcccatc ccatcccatc ccatcccatc   1219

 ccgctctttt cctacttttc cttccctcaa agcttccatt ccacatccgg aggagaagaa   1279

 ggaaatgaat ttctctacag atgtcccatt ttcagactgc tttaaaaaaa atccttctaa   1339

 tctgctatgc ttgaatgcca cgcggtacaa aggaaaaagt atcatggaaa tattatgcaa   1399

 attcccagat ttgaagacaa aaatactcta attctaacca gagcaagctt ttttattttt   1459

 tatacagggg aatattttat tcaaggtaaa attctaaata aaatataatt gttttttatc   1519

 ttttctacag caaatttata attttaagat tccttttctt gtttatcagc agttgttatt   1579

 acatccttgt ggcacatttt tttttaattt tgtaaaggtg aaaaaagctt ttatgagctc   1639

 atctagcaat cagattttcc tgtgga                                        1665




      <210> 66
      <211> 2086
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(1655)

      <400> 66
 gacttctcca gacaggttat gttacctgca gaggctgccc tgaagctccc tgtggcctgg     60

 agact    atg tac aag agg aat ggt ctg atg gct agc gtg ttg gtc acc     107
          Met Tyr Lys Arg Asn Gly Leu Met Ala Ser Val Leu Val Thr
            1               5                  10

 tct gcc act cca cag ggc agc agc agc tcg gac tct ctg gag ggc cag      155
 Ser Ala Thr Pro Gln Gly Ser Ser Ser Ser Asp Ser Leu Glu Gly Gln
  15                  20                  25                  30

 agc tgc gac tat gcc agc aag agc tat gat gcc gtt gtc ttc gat gtc      203
 Ser Cys Asp Tyr Ala Ser Lys Ser Tyr Asp Ala Val Val Phe Asp Val
                  35                  40                  45

 ttg aaa gtg acc cca gag gag ttt gct agc cag att aca tta atg gat      251
 Leu Lys Val Thr Pro Glu Glu Phe Ala Ser Gln Ile Thr Leu Met Asp
              50                  55                  60

 ata cct gtg ttt aaa gct atc cag ccg gag gaa cta gcc agc tgt gga      299
 Ile Pro Val Phe Lys Ala Ile Gln Pro Glu Glu Leu Ala Ser Cys Gly
          65                  70                  75

 tgg agt aag aag gag aaa cac agt ctt gcc cct aac gtt gtg gcc ttt      347
 Trp Ser Lys Lys Glu Lys His Ser Leu Ala Pro Asn Val Val Ala Phe
      80                  85                  90

 acc cgg agg ttt aac cag gtc agt ttt tgg gtt gta cga gaa att cta      395
 Thr Arg Arg Phe Asn Gln Val Ser Phe Trp Val Val Arg Glu Ile Leu
  95                 100                 105                 110

 aca gca cag act tta aaa ata agg gca gaa atc ctc agc cat ttt gtg      443
 Thr Ala Gln Thr Leu Lys Ile Arg Ala Glu Ile Leu Ser His Phe Val
                 115                 120                 125

 aaa ata gcc aag aaa ctt cta gaa ctc aac aac ctt cat tct ctc atg      491
 Lys Ile Ala Lys Lys Leu Leu Glu Leu Asn Asn Leu His Ser Leu Met
             130                 135                 140

 tct gtg gta tca gca tta caa agt gct ccc atc ttc agg ctg aca aaa      539
 Ser Val Val Ser Ala Leu Gln Ser Ala Pro Ile Phe Arg Leu Thr Lys
         145                 150                 155

 acc tgg gct ctt tta aat cga aaa gac aag act acc ttt gag aaa ttg      587
 Thr Trp Ala Leu Leu Asn Arg Lys Asp Lys Thr Thr Phe Glu Lys Leu
     160                 165                 170

 gac tac ctg atg tcg aaa gaa gat aat tac aag cgg aca cgg gaa tat      635
 Asp Tyr Leu Met Ser Lys Glu Asp Asn Tyr Lys Arg Thr Arg Glu Tyr
 175                 180                 185                 190

 atc cga agc ctg aag atg gtt cca agt att ccc tat cta gga atc tat      683
 Ile Arg Ser Leu Lys Met Val Pro Ser Ile Pro Tyr Leu Gly Ile Tyr
                 195                 200                 205

 ctt ctg gat tta atc tac att gat tct gca tat cct gcc tca ggc agt      731
 Leu Leu Asp Leu Ile Tyr Ile Asp Ser Ala Tyr Pro Ala Ser Gly Ser
             210                 215                 220

 atc atg gaa aat gaa caa aga tcc aat cag atg aac aat att ctt cga      779
 Ile Met Glu Asn Glu Gln Arg Ser Asn Gln Met Asn Asn Ile Leu Arg
         225                 230                 235

 ata att gct gat tta caa gtt tcc tgc agc tat gat cac ctc acc acc      827
 Ile Ile Ala Asp Leu Gln Val Ser Cys Ser Tyr Asp His Leu Thr Thr
     240                 245                 250

 ctg ccc cat gtg cag aag tac ctg aag tcc gta cgc tac att gaa gag      875
 Leu Pro His Val Gln Lys Tyr Leu Lys Ser Val Arg Tyr Ile Glu Glu
 255                 260                 265                 270

 ctc cag aag ttt gtg gaa gac gac aac tac aaa ctg tcg ctc aga atc      923
 Leu Gln Lys Phe Val Glu Asp Asp Asn Tyr Lys Leu Ser Leu Arg Ile
                 275                 280                 285

 gaa cca gga agc agc tct cca aga cta gtc tct tcc aag gaa gat ctt      971
 Glu Pro Gly Ser Ser Ser Pro Arg Leu Val Ser Ser Lys Glu Asp Leu
             290                 295                 300

 gca ggt ccc tct gct ggc tcc ggt tct gcg agg ttc agc cgg agg ccc     1019
 Ala Gly Pro Ser Ala Gly Ser Gly Ser Ala Arg Phe Ser Arg Arg Pro
         305                 310                 315

 acc tgt cct gac aca tct gtt gct ggc agc ctc ccc aca cct cca gtc     1067
 Thr Cys Pro Asp Thr Ser Val Ala Gly Ser Leu Pro Thr Pro Pro Val
     320                 325                 330

 ccc aga cac agg aag agc cac agc cta ggc aac aac agg gga cgt ctc     1115
 Pro Arg His Arg Lys Ser His Ser Leu Gly Asn Asn Arg Gly Arg Leu
 335                 340                 345                 350

 tat gcc acc ctg ggg ccc aac tgg cgg gtt cca gtt agg aat tct ccc     1163
 Tyr Ala Thr Leu Gly Pro Asn Trp Arg Val Pro Val Arg Asn Ser Pro
                 355                 360                 365

 aga acc cgg agc tgt gtc tac agc ccc acc ggc ccg tgc atc tgt tct     1211
 Arg Thr Arg Ser Cys Val Tyr Ser Pro Thr Gly Pro Cys Ile Cys Ser
             370                 375                 380

 ctg ggg aac tcc gca gct gtg ccc acc atg gag ggg cct ctg aga aga     1259
 Leu Gly Asn Ser Ala Ala Val Pro Thr Met Glu Gly Pro Leu Arg Arg
         385                 390                 395

 aaa acc ctg ctc aag gaa ggg cgg aag cct gcg ctg tcc tcg tgg acc     1307
 Lys Thr Leu Leu Lys Glu Gly Arg Lys Pro Ala Leu Ser Ser Trp Thr
     400                 405                 410

 agg tac tgg gtc ata ctc tca gga tcc acc ctc ctg tac tac gga gcc     1355
 Arg Tyr Trp Val Ile Leu Ser Gly Ser Thr Leu Leu Tyr Tyr Gly Ala
 415                 420                 425                 430

 aag tcc ttg cgg ggc aca gac aga aaa cac gtt tcc atc gtg ggc tgg     1403
 Lys Ser Leu Arg Gly Thr Asp Arg Lys His Val Ser Ile Val Gly Trp
                 435                 440                 445

 atg gtg cag ctg ccc gat gac ccc gag cac cca gat atc ttc cag ctg     1451
 Met Val Gln Leu Pro Asp Asp Pro Glu His Pro Asp Ile Phe Gln Leu
             450                 455                 460

 aac aac cct gac aaa ggc aat gtt tac aag ttt cag act ggt tcc cga     1499
 Asn Asn Pro Asp Lys Gly Asn Val Tyr Lys Phe Gln Thr Gly Ser Arg
         465                 470                 475

 ttt cat gca ata ctg tgg cac aag cat ttg gat gat gca tgt aaa agc     1547
 Phe His Ala Ile Leu Trp His Lys His Leu Asp Asp Ala Cys Lys Ser
     480                 485                 490

 aac agg cct cag gaa gcc gga gca gct cca ggt cca aca gga act gac     1595
 Asn Arg Pro Gln Glu Ala Gly Ala Ala Pro Gly Pro Thr Gly Thr Asp
 495                 500                 505                 510

 agc cac gag gtg gac cac ctg gag ggc ggt gcg ggg aag gag gca ggg     1643
 Ser His Glu Val Asp His Leu Glu Gly Gly Ala Gly Lys Glu Ala Gly
                 515                 520                 525

 ccc tgt gcc tga agc ctgggcacca tggtggcccc agtcaggagc aacagtggta     1698
 Pro Cys Ala 


 gccctgagta aaacccattg tccctctttg gaggagcggc cagaggatga cagcagcccc   1758

 agcaggcagc agtgcctggg caggctgatc cagcagagca ctaatgggtc agtttcatgt   1818

 attggcagat gtggtgtagc atggcaaggc tacaagtttt aaggattttt gtctgatttt   1878

 cagacctgga ggaggggatt tttcttccta ctttccccct tttttatttc taatttactt   1938

 tcaaccaaat attcccacta tgtgctatat gtaataataa aaagttgaca acaactgaaa   1998

 tattcaacag cagaggatga tttaagtgaa tcacagtaca tccgtgtgat ggaatgccag   2058

 gagggtgtaa gaaagagtgt gacagaat                                      2086




      <210> 67
      <211> 1986
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(1314)

      <400> 67
 cgcgctcgga atttccgggt cgacgatctc gtcggtctct tccctcaccc ttccccgcgc     60

 ccccatcttt tcctccctcc ctcccacccc tctgcagcg   atg gca gag gaa caa     114
                                              Met Ala Glu Glu Gln
                                                1               5

 caa cag ccg cca cca cag cag cct gat gcc cat cag cag ctt ccc ccc      162
 Gln Gln Pro Pro Pro Gln Gln Pro Asp Ala His Gln Gln Leu Pro Pro
                  10                  15                  20

 agc gcc ccc aac tcg ggg gtg gcc ctg cca gcc ctt gtg ccc ggg ctg      210
 Ser Ala Pro Asn Ser Gly Val Ala Leu Pro Ala Leu Val Pro Gly Leu
              25                  30                  35

 cca ggg aca gag gcc agc gcg ctg caa cac aag atc aag aac tcc atc      258
 Pro Gly Thr Glu Ala Ser Ala Leu Gln His Lys Ile Lys Asn Ser Ile
          40                  45                  50

 tgc aaa act gta caa tct aaa gtg gac tgc att ttg caa gaa gtt gag      306
 Cys Lys Thr Val Gln Ser Lys Val Asp Cys Ile Leu Gln Glu Val Glu
      55                  60                  65

 aag ttt aca gac cta gag aaa ctc tac ctc tac ctt cag ctg cct tct      354
 Lys Phe Thr Asp Leu Glu Lys Leu Tyr Leu Tyr Leu Gln Leu Pro Ser
  70                  75                  80                  85

 ggt ctc agc aat gga gag aaa agt gat cag aat gcc atg tca tct agt      402
 Gly Leu Ser Asn Gly Glu Lys Ser Asp Gln Asn Ala Met Ser Ser Ser
                  90                  95                 100

 cgg gca caa caa atg cat gcc ttt tcc tgg att cgg aat acc cta gag      450
 Arg Ala Gln Gln Met His Ala Phe Ser Trp Ile Arg Asn Thr Leu Glu
             105                 110                 115

 gaa cat ccg gag act tca ctg ccc aaa cag gaa gtc tat gat gag tac      498
 Glu His Pro Glu Thr Ser Leu Pro Lys Gln Glu Val Tyr Asp Glu Tyr
         120                 125                 130

 aag agc tat tgt gac aat ctt ggt tac cat cca tta agt gct gct gat      546
 Lys Ser Tyr Cys Asp Asn Leu Gly Tyr His Pro Leu Ser Ala Ala Asp
     135                 140                 145

 ttt gga aag atc atg aaa aac gtc ttt cca aac atg aag gca cgt cgt      594
 Phe Gly Lys Ile Met Lys Asn Val Phe Pro Asn Met Lys Ala Arg Arg
 150                 155                 160                 165

 ttg ggc aca aga ggc aaa tct aaa tat tgc tac agt gga cta aga aaa      642
 Leu Gly Thr Arg Gly Lys Ser Lys Tyr Cys Tyr Ser Gly Leu Arg Lys
                 170                 175                 180

 aaa gct ttt gtt cat atg cca aca ctg ccc aac ctt gac ttt cac aaa      690
 Lys Ala Phe Val His Met Pro Thr Leu Pro Asn Leu Asp Phe His Lys
             185                 190                 195

 act gga aat ggg ttg gaa gga gct gaa cct tct ggg cag ctt caa aat      738
 Thr Gly Asn Gly Leu Glu Gly Ala Glu Pro Ser Gly Gln Leu Gln Asn
         200                 205                 210

 att gat gaa gaa gtt atc tct tct gct tgc cgt ctt gtg tgt gag tgg      786
 Ile Asp Glu Glu Val Ile Ser Ser Ala Cys Arg Leu Val Cys Glu Trp
     215                 220                 225

 gcc cag aaa gtg tta agc caa cca ttt gac acc gtc ttg gaa tta gcc      834
 Ala Gln Lys Val Leu Ser Gln Pro Phe Asp Thr Val Leu Glu Leu Ala
 230                 235                 240                 245

 cgc ttc ctt gta aaa agt cac tat ata ggc acc aag tca atg gca gct      882
 Arg Phe Leu Val Lys Ser His Tyr Ile Gly Thr Lys Ser Met Ala Ala
                 250                 255                 260

 cta act gta atg gca gca gca cca gca gga atg aaa gga att acc cag      930
 Leu Thr Val Met Ala Ala Ala Pro Ala Gly Met Lys Gly Ile Thr Gln
             265                 270                 275

 cct tct gct ttt ata cct aca gct gaa agt aat tcc ttt cag cct cag      978
 Pro Ser Ala Phe Ile Pro Thr Ala Glu Ser Asn Ser Phe Gln Pro Gln
         280                 285                 290

 gtg aag act ttg cca tct cca att gat gct aaa cag cag ttg caa cgg     1026
 Val Lys Thr Leu Pro Ser Pro Ile Asp Ala Lys Gln Gln Leu Gln Arg
     295                 300                 305

 aaa atc cag aag aag cag caa gaa cag aaa cta caa tcc cct ttg cca     1074
 Lys Ile Gln Lys Lys Gln Gln Glu Gln Lys Leu Gln Ser Pro Leu Pro
 310                 315                 320                 325

 gga gaa tct gca gca aaa aag tca gaa agt gct aca agc aat gga gtg     1122
 Gly Glu Ser Ala Ala Lys Lys Ser Glu Ser Ala Thr Ser Asn Gly Val
                 330                 335                 340

 act aat ctt cct aat gga aat cct tca atc ctt tct cct caa cct att     1170
 Thr Asn Leu Pro Asn Gly Asn Pro Ser Ile Leu Ser Pro Gln Pro Ile
             345                 350                 355

 ggt atc gtt atg gca gct gtc cct agt ccc att ccg gtc cag cgg act     1218
 Gly Ile Val Met Ala Ala Val Pro Ser Pro Ile Pro Val Gln Arg Thr
         360                 365                 370

 agg cat ttg gta act tca ccg agt cca atg agt tct tct gac ggc aaa     1266
 Arg His Leu Val Thr Ser Pro Ser Pro Met Ser Ser Ser Asp Gly Lys
     375                 380                 385

 gtt ctt ccc ctc aat gta cag gtg tca ctc agc aca tgc agt ctg tga     1314
 Val Leu Pro Leu Asn Val Gln Val Ser Leu Ser Thr Cys Ser Leu 
 390                 395                 400

 aacaggcacc aaagactccc cagaacgttc cagccagtcc tggtggggat cgttctgccc   1374

 ggcaccgtta ccctcagatc ttacccaaac cagcgaacac cagtgcactc accattcgct   1434

 ctccaactac tgtcctcttt actagtagtc ccatcaaaac tgctgttgta cccgcttcac   1494

 acatgagttc tctaaatgtg gtgaaaatga caacaatatc cctcacaccc agcaacagta   1554

 acacccctct taaacattct gcctcagtca gcagtgctac aggaacaaca gaagaatcaa   1614

 ggagtgttcc acagatcaag aatggttctg tcgtgtcgct tcagtctcct gggtccagga   1674

 acagcagtgc ggggggaaca tatgctgtgg aagtcaaagt ggaacccgaa acatcatcag   1734

 atgagcgtcc tgtacagtgc caagagatct ctgatgaggc taaagctccc cagacaccta   1794

 gtgccctttt ggggcagaaa agtaatacag acggagccct gcagaaacct tcaaatgaag   1854

 gtgtcattga aataaaagca actaaggtct gtgaccagag gaccaaatgt aaaagtcgct   1914

 gtaatgaaat gctgccaggc acgaatggcg aagcgaccgc tctagaggat ccaagctgac   1974

 gtctgctagc at                                                       1986




      <210> 68
      <211> 946
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(608)

      <400> 68
 tctgtgtcga cccacgcgtc cggcggttcg cgcgcttcgg gcctagtccg gactcgccgc     60

 cgccgccgcc atattcccgt ggcatcttcc ttactttgtc catcctccgg actcgcgatc    120

 ttccttccgg agcc  atg tca gaa gga gtg gac ttg att gat ata tat gct     170
                  Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala
                    1               5                  10

 gac gag gag ttc aac cag gac cca gag ttc aac aat aca gat cag att      218
 Asp Glu Glu Phe Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile
          15                  20                  25

 gac ctg tat gat gat gtg ctg aca gcc acc tca cag ccc tca gat gac      266
 Asp Leu Tyr Asp Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp
      30                  35                  40

 aga agc agc agc act gaa cca cct cct cct gtt cgc cag gag cca tct      314
 Arg Ser Ser Ser Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser
  45                  50                  55                  60

 ccc aag ccc aac aac aag acc cct gca att ctg tat acc tac agt ggc      362
 Pro Lys Pro Asn Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly
                  65                  70                  75

 ctg cgt aat aga cga gct gcc gtt tat gtg ggc agc ttc tcc tgg tgg      410
 Leu Arg Asn Arg Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp
              80                  85                  90

 acc aca gac cag cag ctg atc cag gtt att cgc tct ata gga gtc tat      458
 Thr Thr Asp Gln Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr
          95                 100                 105

 gat gtg gtg gag ttg aaa ttt gca gag aat cga gca aat ggc cag tcc      506
 Asp Val Val Glu Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser
     110                 115                 120

 aaa ggg tat gct gag gtg gtg gta gcc tct gaa aac tct gtc cac aaa      554
 Lys Gly Tyr Ala Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys
 125                 130                 135                 140

 ttg ttg gaa ctc cta cca ggg aaa gtt ctt aac tgg cag aaa aag tgg      602
 Leu Leu Glu Leu Leu Pro Gly Lys Val Leu Asn Trp Gln Lys Lys Trp
                 145                 150                 155

 acg tga gtgccggcca ccctggcaga acctgtcaca gtttgaggca caggctcgga       658
 Thr 


 aacgaatacc tccacgggcc cattcccgag attctagtga ttctgctgat ggactgggcc    718

 acaccctctg agaaccttgt accctcatct gctcgtgtgg ataagccccc cagtgtgctg    778

 ccctacttca atacgtccta ccttacggcc cttacacctg atgagtacta gccaccacaa    838

 caaattacaa ccacaaacac tactacacct caaagcaagg acgaccacac atactacata    898

 cttgatctac cactaacaga atctcaatgc cccacctcac taattacc                 946




      <210> 69
      <211> 1244
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (31)..(1095)

      <400> 69
 tggaagcacg cacagttgtg accatcaagt     atg cag gaa gca atc att ctc      51
                                      Met Gln Glu Ala Ile Ile Leu
                                        1               5

 ctg gct ctc ctg ggt gcc atg tca ggg gga gaa gca cta cac cta atc       99
 Leu Ala Leu Leu Gly Ala Met Ser Gly Gly Glu Ala Leu His Leu Ile
          10                  15                  20

 ctc tta cct gct aca ggc aat gtg gca gag aat tct cca cct ggg act      147
 Leu Leu Pro Ala Thr Gly Asn Val Ala Glu Asn Ser Pro Pro Gly Thr
      25                  30                  35

 tca gtg cac aag ttt tct gtg aag tta tca gca tca ttg tca cct gtg      195
 Ser Val His Lys Phe Ser Val Lys Leu Ser Ala Ser Leu Ser Pro Val
  40                  45                  50                  55

 atc cca gga ttt ccc cag ata gtc aac tca aat ccc ctc act gaa gct      243
 Ile Pro Gly Phe Pro Gln Ile Val Asn Ser Asn Pro Leu Thr Glu Ala
                  60                  65                  70

 ttt agg gtg aat tgg ctg tca ggc acc tac ttt gag gtt gtc acc act      291
 Phe Arg Val Asn Trp Leu Ser Gly Thr Tyr Phe Glu Val Val Thr Thr
              75                  80                  85

 ggg atg gaa caa cta gat ttt gaa aca gga cca aac ata ttt gat ttg      339
 Gly Met Glu Gln Leu Asp Phe Glu Thr Gly Pro Asn Ile Phe Asp Leu
          90                  95                 100

 cag att tat gtg aag gat gag gtt ggt gtc aca gac ctt caa gtc ctg      387
 Gln Ile Tyr Val Lys Asp Glu Val Gly Val Thr Asp Leu Gln Val Leu
     105                 110                 115

 act gtc cag gta aca gat gtg aac gag cca cct cag ttt caa ggc aac      435
 Thr Val Gln Val Thr Asp Val Asn Glu Pro Pro Gln Phe Gln Gly Asn
 120                 125                 130                 135

 ttg gca gaa ggt cta cac ctc tac ata gta gaa aga gca aac cct gga      483
 Leu Ala Glu Gly Leu His Leu Tyr Ile Val Glu Arg Ala Asn Pro Gly
                 140                 145                 150

 ttc att tac cag gtt gag gcc ttc gat cca gaa gac aca agc cga aac      531
 Phe Ile Tyr Gln Val Glu Ala Phe Asp Pro Glu Asp Thr Ser Arg Asn
             155                 160                 165

 att ccc ctc agt tat ttc ctg att tct ccc cca aag agc ttc aga atg      579
 Ile Pro Leu Ser Tyr Phe Leu Ile Ser Pro Pro Lys Ser Phe Arg Met
         170                 175                 180

 tct gct aat ggc acc ctc ttc tcc aca aca gaa ttg gac ttt gaa gca      627
 Ser Ala Asn Gly Thr Leu Phe Ser Thr Thr Glu Leu Asp Phe Glu Ala
     185                 190                 195

 gga cac aga agt ttc cat ctc atc gtg gag gtg agg gac agt gga ggc      675
 Gly His Arg Ser Phe His Leu Ile Val Glu Val Arg Asp Ser Gly Gly
 200                 205                 210                 215

 ctc aaa gcc tcc aca gag ctc cag gtg aac atc gtg aac ctc aac gac      723
 Leu Lys Ala Ser Thr Glu Leu Gln Val Asn Ile Val Asn Leu Asn Asp
                 220                 225                 230

 gaa gtc cct cgc ttt acc agc ccg aca cga gtg tac aca gtc ctg gag      771
 Glu Val Pro Arg Phe Thr Ser Pro Thr Arg Val Tyr Thr Val Leu Glu
             235                 240                 245

 gaa ctg agt cca gga acc atc gtg gcc aat atc aca gcg gag gat cct      819
 Glu Leu Ser Pro Gly Thr Ile Val Ala Asn Ile Thr Ala Glu Asp Pro
         250                 255                 260

 gat gat gaa ggt ttt ccc agc cac ctc ctc tac agc att acc act gtt      867
 Asp Asp Glu Gly Phe Pro Ser His Leu Leu Tyr Ser Ile Thr Thr Val
     265                 270                 275

 agc aaa tat ttc atg ata aat cag ttg act ggt aca atc caa gtg gcc      915
 Ser Lys Tyr Phe Met Ile Asn Gln Leu Thr Gly Thr Ile Gln Val Ala
 280                 285                 290                 295

 caa agg ata gac cga gat gca ggt gaa ttg aga caa aat ccc acc att      963
 Gln Arg Ile Asp Arg Asp Ala Gly Glu Leu Arg Gln Asn Pro Thr Ile
                 300                 305                 310

 tcc ctg gaa gtt cta gtg aag gac aga cca tat ggg ggt cag gag aat     1011
 Ser Leu Glu Val Leu Val Lys Asp Arg Pro Tyr Gly Gly Gln Glu Asn
             315                 320                 325

 cgc atc cag ata acc ttc att gtg gaa gac gtc aac gac aat cct gcc     1059
 Arg Ile Gln Ile Thr Phe Ile Val Glu Asp Val Asn Asp Asn Pro Ala
         330                 335                 340

 aca tgc caa aag ttc acc ttc aga tgg agg aac tga aacc tggagacatg     1109
 Thr Cys Gln Lys Phe Thr Phe Arg Trp Arg Asn 
     345                 350

 agaaagcccc tcaatgaatg gaagtctcaa ggtgttcatt ggtcttcctc agagcctcct   1169

 acagcaagct gggcttgatc ggaaggctct gagtttgggg gtagctttac tcatttgtgt   1229

 ttcagaacaa cgaca                                                    1244




      <210> 70
      <211> 5273
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(4832)

      <400> 70
 gtgccctgca catccctggc tgtaaggtgg ttccattctg tggggtgttt ctgaaggagc     60

 tctgtgaagt gcttgacggc gcctccggtc tc  atg aag ctt tgc ccg cgg tac     113
                                      Met Lys Leu Cys Pro Arg Tyr
                                        1               5

 aat tcc caa gaa gaa act tta gag ttt gta gca gat tac agt gga caa      161
 Asn Ser Gln Glu Glu Thr Leu Glu Phe Val Ala Asp Tyr Ser Gly Gln
          10                  15                  20

 gat aat ttc tta caa cga gtg gga caa aat ggc tta aag aat tcg gag      209
 Asp Asn Phe Leu Gln Arg Val Gly Gln Asn Gly Leu Lys Asn Ser Glu
      25                  30                  35

 aag gag tcc act gtc aac agc atc ttt cag gtc atc cgg agc tgc aat      257
 Lys Glu Ser Thr Val Asn Ser Ile Phe Gln Val Ile Arg Ser Cys Asn
  40                  45                  50                  55

 cga agt ctg gag aca gac gag gag gac agc ccc agt gaa gga aac agc      305
 Arg Ser Leu Glu Thr Asp Glu Glu Asp Ser Pro Ser Glu Gly Asn Ser
                  60                  65                  70

 tcc agg aaa agc tcc ttg aag gat aaa agc cga tgg cag ttt ata att      353
 Ser Arg Lys Ser Ser Leu Lys Asp Lys Ser Arg Trp Gln Phe Ile Ile
              75                  80                  85

 gga gat ttg ttg gat tca gac aat gac atc ttt gag caa tcc aaa gaa      401
 Gly Asp Leu Leu Asp Ser Asp Asn Asp Ile Phe Glu Gln Ser Lys Glu
          90                  95                 100

 tac gac tct cat ggt tca gag gac tca cag aag gcc ttc gac cat ggg      449
 Tyr Asp Ser His Gly Ser Glu Asp Ser Gln Lys Ala Phe Asp His Gly
     105                 110                 115

 acg gag ctc atc cct tgg tac gtg ctg tcc atc caa gcc gat gtg cac      497
 Thr Glu Leu Ile Pro Trp Tyr Val Leu Ser Ile Gln Ala Asp Val His
 120                 125                 130                 135

 cag ttc ctg ctg cag ggg gcc acg gtc atc cac tac gac cag gac aca      545
 Gln Phe Leu Leu Gln Gly Ala Thr Val Ile His Tyr Asp Gln Asp Thr
                 140                 145                 150

 cac ctc tct gcc cgc tgc ttc ctc cag ctt cag ccc gac aat agc acc      593
 His Leu Ser Ala Arg Cys Phe Leu Gln Leu Gln Pro Asp Asn Ser Thr
             155                 160                 165

 ttg acc tgg gta aag ccc aca act gcc tcc cca gcc agc agt aaa gca      641
 Leu Thr Trp Val Lys Pro Thr Thr Ala Ser Pro Ala Ser Ser Lys Ala
         170                 175                 180

 aaa ctt ggt gta ctt aat aac aca gct gag cct gga aaa ttc cca cta      689
 Lys Leu Gly Val Leu Asn Asn Thr Ala Glu Pro Gly Lys Phe Pro Leu
     185                 190                 195

 ctg ggt aat gct gga tta agt agc ctg acg gaa ggg gtc ttg gat ctt      737
 Leu Gly Asn Ala Gly Leu Ser Ser Leu Thr Glu Gly Val Leu Asp Leu
 200                 205                 210                 215

 ttt gca gtg aag gct gta tac atg ggc cac cct ggc att gat ata cac      785
 Phe Ala Val Lys Ala Val Tyr Met Gly His Pro Gly Ile Asp Ile His
                 220                 225                 230

 act gtg tgt gtt cag aac aaa ctg ggt agc atg ttc ctg tca gag act      833
 Thr Val Cys Val Gln Asn Lys Leu Gly Ser Met Phe Leu Ser Glu Thr
             235                 240                 245

 ggt gtg aca ttg ctc tat ggg ctt cag acc aca gac aac aga tta ttg      881
 Gly Val Thr Leu Leu Tyr Gly Leu Gln Thr Thr Asp Asn Arg Leu Leu
         250                 255                 260

 cac ttc gtg gca cca aag cac aca gct aaa atg ctc ttc agc gga tta      929
 His Phe Val Ala Pro Lys His Thr Ala Lys Met Leu Phe Ser Gly Leu
     265                 270                 275

 ttg gaa ctc act aga gct gtg aga aag atg agg aaa ttc cct gac caa      977
 Leu Glu Leu Thr Arg Ala Val Arg Lys Met Arg Lys Phe Pro Asp Gln
 280                 285                 290                 295

 aga cag cag tgg ctg cgg aaa cag tac gtc agc ctt tat cag gag gat     1025
 Arg Gln Gln Trp Leu Arg Lys Gln Tyr Val Ser Leu Tyr Gln Glu Asp
                 300                 305                 310

 gga cgg tat gaa ggc cca act ttg gct cac gct gtg gag ttg ttt ggt     1073
 Gly Arg Tyr Glu Gly Pro Thr Leu Ala His Ala Val Glu Leu Phe Gly
             315                 320                 325

 ggc aga cgg tgg agt gct cga aac ccc agc ccc gga aca tca gca aag     1121
 Gly Arg Arg Trp Ser Ala Arg Asn Pro Ser Pro Gly Thr Ser Ala Lys
         330                 335                 340

 aat gct gag aag ccc aat atg cag aga aac aat acc ctg ggc ata agc     1169
 Asn Ala Glu Lys Pro Asn Met Gln Arg Asn Asn Thr Leu Gly Ile Ser
     345                 350                 355

 act acc aag aaa aag aag aaa atc ctc atg agg ggt gag agt gga gag     1217
 Thr Thr Lys Lys Lys Lys Lys Ile Leu Met Arg Gly Glu Ser Gly Glu
 360                 365                 370                 375

 gta act gac gat gag atg gca acc cga aag gcc aag atg cac aaa gag     1265
 Val Thr Asp Asp Glu Met Ala Thr Arg Lys Ala Lys Met His Lys Glu
                 380                 385                 390

 tgt cga agc cgg agt ggt tct gat cct caa gac att aat gaa caa gaa     1313
 Cys Arg Ser Arg Ser Gly Ser Asp Pro Gln Asp Ile Asn Glu Gln Glu
             395                 400                 405

 gaa tca gag gtg aat gcc atc gct aac cct cca aac ccc ctc cct tcc     1361
 Glu Ser Glu Val Asn Ala Ile Ala Asn Pro Pro Asn Pro Leu Pro Ser
         410                 415                 420

 aga aga gcc cac tct ttg acc aca gct ggg tcc ccc aac ttg gct gcc     1409
 Arg Arg Ala His Ser Leu Thr Thr Ala Gly Ser Pro Asn Leu Ala Ala
     425                 430                 435

 ggg acg tca tct ccc atc agg cca gtg tcc tcc cct gtg ctg tct tct     1457
 Gly Thr Ser Ser Pro Ile Arg Pro Val Ser Ser Pro Val Leu Ser Ser
 440                 445                 450                 455

 tca aac aag agc cca tcc agt gct tgg agc agt agt agc tgg cac ggg     1505
 Ser Asn Lys Ser Pro Ser Ser Ala Trp Ser Ser Ser Ser Trp His Gly
                 460                 465                 470

 cgg atc aaa ggc ggc atg aag gga ttt cag agc ttc atg gtt tca gat     1553
 Arg Ile Lys Gly Gly Met Lys Gly Phe Gln Ser Phe Met Val Ser Asp
             475                 480                 485

 agc aac atg agt ttt gtt gaa ttt gtt gag ctg ttc aaa tca ttc agt     1601
 Ser Asn Met Ser Phe Val Glu Phe Val Glu Leu Phe Lys Ser Phe Ser
         490                 495                 500

 gtc agg cag gcg aag gac ctg aag gat ctg ttt gat gtc tat gca gtg     1649
 Val Arg Gln Ala Lys Asp Leu Lys Asp Leu Phe Asp Val Tyr Ala Val
     505                 510                 515

 ccc tgc aac cga tct ggc tcc gag tca gcc cca ctc tac acc aac ctg     1697
 Pro Cys Asn Arg Ser Gly Ser Glu Ser Ala Pro Leu Tyr Thr Asn Leu
 520                 525                 530                 535

 aca att gat gaa aac acc agc gat ctt cag cct gac cta gat ctg ttg     1745
 Thr Ile Asp Glu Asn Thr Ser Asp Leu Gln Pro Asp Leu Asp Leu Leu
                 540                 545                 550

 acc aga aat gtc tcg gat ttg ggg ttg ttc att aag agt aaa cag cag     1793
 Thr Arg Asn Val Ser Asp Leu Gly Leu Phe Ile Lys Ser Lys Gln Gln
             555                 560                 565

 cta tcg gac aac cag agg cag ata tct gat gcc att gct gct gca agc     1841
 Leu Ser Asp Asn Gln Arg Gln Ile Ser Asp Ala Ile Ala Ala Ala Ser
         570                 575                 580

 att gtg aca aat ggc act ggg att gag agc aca tct ctg ggc att ttt     1889
 Ile Val Thr Asn Gly Thr Gly Ile Glu Ser Thr Ser Leu Gly Ile Phe
     585                 590                 595

 ggg gtg ggc ata ctt cag ctc aac gat ttc ctc gtg aat tgc caa gga     1937
 Gly Val Gly Ile Leu Gln Leu Asn Asp Phe Leu Val Asn Cys Gln Gly
 600                 605                 610                 615

 gaa cac tgc act tat gat gaa atc ctc agc atc atc cag aag ttc gag     1985
 Glu His Cys Thr Tyr Asp Glu Ile Leu Ser Ile Ile Gln Lys Phe Glu
                 620                 625                 630

 cct agc atc agt atg tgt cat cag gga cta atg tca ttt gaa ggg ttt     2033
 Pro Ser Ile Ser Met Cys His Gln Gly Leu Met Ser Phe Glu Gly Phe
             635                 640                 645

 gcc agg ttt ctg atg gat aaa gaa aat ttt gcc tca aaa aat gat gag     2081
 Ala Arg Phe Leu Met Asp Lys Glu Asn Phe Ala Ser Lys Asn Asp Glu
         650                 655                 660

 tca cag gag aac att aaa gaa ctg cag cta ccc ctc tca tac tat tac     2129
 Ser Gln Glu Asn Ile Lys Glu Leu Gln Leu Pro Leu Ser Tyr Tyr Tyr
     665                 670                 675

 atc gaa tct tcg cac aat acc tac ctc acg ggc cat cag ctc aaa gga     2177
 Ile Glu Ser Ser His Asn Thr Tyr Leu Thr Gly His Gln Leu Lys Gly
 680                 685                 690                 695

 gaa tcc tcg gta gaa ctc tac agc cag gtc ctt ttg caa ggc tgt cga     2225
 Glu Ser Ser Val Glu Leu Tyr Ser Gln Val Leu Leu Gln Gly Cys Arg
                 700                 705                 710

 agt gta gaa ttg gac tgc tgg gac gga gac gat ggg atg ccc atc att     2273
 Ser Val Glu Leu Asp Cys Trp Asp Gly Asp Asp Gly Met Pro Ile Ile
             715                 720                 725

 tat cat gga cat acg ctg aca acc aag atc ccc ttc aag gaa gtg gtt     2321
 Tyr His Gly His Thr Leu Thr Thr Lys Ile Pro Phe Lys Glu Val Val
         730                 735                 740

 gaa gcc att gat cgc agt gcc ttc atc aac tct gac ctg cca atc atc     2369
 Glu Ala Ile Asp Arg Ser Ala Phe Ile Asn Ser Asp Leu Pro Ile Ile
     745                 750                 755

 ata tcg att gag aac cac tgt tca ttg cct cag caa cga aaa atg gca     2417
 Ile Ser Ile Glu Asn His Cys Ser Leu Pro Gln Gln Arg Lys Met Ala
 760                 765                 770                 775

 gaa att ttc aag act gtg ttt gga gaa aag ctg gtg act aaa ttc tta     2465
 Glu Ile Phe Lys Thr Val Phe Gly Glu Lys Leu Val Thr Lys Phe Leu
                 780                 785                 790

 ttt gag act gat ttc tca gat gat cca atg ctt cct tca cct gac caa     2513
 Phe Glu Thr Asp Phe Ser Asp Asp Pro Met Leu Pro Ser Pro Asp Gln
             795                 800                 805

 ctc aga aag aaa gtt ctt ctt aaa aac aag aag cta aaa gcc cat cag     2561
 Leu Arg Lys Lys Val Leu Leu Lys Asn Lys Lys Leu Lys Ala His Gln
         810                 815                 820

 acg cca gtg gat atc tta aag caa aag gct cat cag tta gca tct atg     2609
 Thr Pro Val Asp Ile Leu Lys Gln Lys Ala His Gln Leu Ala Ser Met
     825                 830                 835

 caa gtg cag gct tat aat ggt ggg aat gcc aac ccc cga cct gcc aat     2657
 Gln Val Gln Ala Tyr Asn Gly Gly Asn Ala Asn Pro Arg Pro Ala Asn
 840                 845                 850                 855

 aat gag gaa gag gaa gat gag gag gac gaa tat gat tat gac tat gaa     2705
 Asn Glu Glu Glu Glu Asp Glu Glu Asp Glu Tyr Asp Tyr Asp Tyr Glu
                 860                 865                 870

 tcc ctt tct gat gac aac att ctg gaa gac aga cct gaa aat aaa tca     2753
 Ser Leu Ser Asp Asp Asn Ile Leu Glu Asp Arg Pro Glu Asn Lys Ser
             875                 880                 885

 tgt aat gac aag ctt cag ttt gaa tat aat gaa gaa atc cca aag agg     2801
 Cys Asn Asp Lys Leu Gln Phe Glu Tyr Asn Glu Glu Ile Pro Lys Arg
         890                 895                 900

 ata aag aaa gca gat aac tct gct tgc aac aaa gga aag gtt tat gat     2849
 Ile Lys Lys Ala Asp Asn Ser Ala Cys Asn Lys Gly Lys Val Tyr Asp
     905                 910                 915

 atg gaa ctg gga gaa gaa ttt tat ctt gat cag aat aaa aag gaa agc     2897
 Met Glu Leu Gly Glu Glu Phe Tyr Leu Asp Gln Asn Lys Lys Glu Ser
 920                 925                 930                 935

 aga cag att gca cca gag ctt tct gac ctt gta atc tat tgt caa gca     2945
 Arg Gln Ile Ala Pro Glu Leu Ser Asp Leu Val Ile Tyr Cys Gln Ala
                 940                 945                 950

 gta aaa ttt cca gga ctg tca act cta aat gca tct ggc tct agc aga     2993
 Val Lys Phe Pro Gly Leu Ser Thr Leu Asn Ala Ser Gly Ser Ser Arg
             955                 960                 965

 gga aaa gaa agg aaa agc agg aag tcc att ttt ggc aac aat ccg ggc     3041
 Gly Lys Glu Arg Lys Ser Arg Lys Ser Ile Phe Gly Asn Asn Pro Gly
         970                 975                 980

 aga atg agc cca ggg gag aca gca tca ttt aac aaa aca tct gga aaa     3089
 Arg Met Ser Pro Gly Glu Thr Ala Ser Phe Asn Lys Thr Ser Gly Lys
     985                 990                 995

 agt tcc tgt gaa ggc att cga cag acc tgg gag gaa tct tct tcc cct     3137
 Ser Ser Cys Glu Gly Ile Arg Gln Thr Trp Glu Glu Ser Ser Ser Pro
1000                1005                1010                1015

 ctc aac cca acc acg tcc ctc agt gct atc att aga act ccc aaa tgt     3185
 Leu Asn Pro Thr Thr Ser Leu Ser Ala Ile Ile Arg Thr Pro Lys Cys
                1020                1025                1030

 tat cat atc tcg tcg ctg aat gaa aat gcc gcc aaa cgt ctg tgt cgc     3233
 Tyr His Ile Ser Ser Leu Asn Glu Asn Ala Ala Lys Arg Leu Cys Arg
            1035                1040                1045

 agg tat tct cag aaa ctg acc cag cac acc gcc tgt cag ctg ctg aga     3281
 Arg Tyr Ser Gln Lys Leu Thr Gln His Thr Ala Cys Gln Leu Leu Arg
        1050                1055                1060

 act tac cct gct gcc acc cgc atc gac tct tcc aac ccg aac ccc ctc     3329
 Thr Tyr Pro Ala Ala Thr Arg Ile Asp Ser Ser Asn Pro Asn Pro Leu
    1065                1070                1075

 atg ttc tgg ctc cat ggg ata cag ctt gtg gca ctc aac tac cag act     3377
 Met Phe Trp Leu His Gly Ile Gln Leu Val Ala Leu Asn Tyr Gln Thr
1080                1085                1090                1095

 gat gat ctc cct tta cat tta aat gct gca atg ttt gag gca aat ggt     3425
 Asp Asp Leu Pro Leu His Leu Asn Ala Ala Met Phe Glu Ala Asn Gly
                1100                1105                1110

 ggt tgt ggt tat gta ttg aaa cct cca gtt ctg tgg gac aag aac tgc     3473
 Gly Cys Gly Tyr Val Leu Lys Pro Pro Val Leu Trp Asp Lys Asn Cys
            1115                1120                1125

 ccc atg tat cag aag ttt tct cca cta gaa aga gat ctg gac agc atg     3521
 Pro Met Tyr Gln Lys Phe Ser Pro Leu Glu Arg Asp Leu Asp Ser Met
        1130                1135                1140

 gat cct gca gtc tat tct tta act att gtc tct ggt cag aat gtg tgc     3569
 Asp Pro Ala Val Tyr Ser Leu Thr Ile Val Ser Gly Gln Asn Val Cys
    1145                1150                1155

 ccc agt aat agc atg gga agc ccg tgc att gaa gtc gac gtc ctg ggc     3617
 Pro Ser Asn Ser Met Gly Ser Pro Cys Ile Glu Val Asp Val Leu Gly
1160                1165                1170                1175

 atg cct ctg gac agc tgc cat ttc cgc aca aag ccc atc cat cga aac     3665
 Met Pro Leu Asp Ser Cys His Phe Arg Thr Lys Pro Ile His Arg Asn
                1180                1185                1190

 acc ctg aac ccc atg tgg aac gag cag ttt ctg ttc cgc gtt cac ttc     3713
 Thr Leu Asn Pro Met Trp Asn Glu Gln Phe Leu Phe Arg Val His Phe
            1195                1200                1205

 gaa gat ctt gta ttt ctt cgt ttt gca gtt gtg gaa aac aat agt tca     3761
 Glu Asp Leu Val Phe Leu Arg Phe Ala Val Val Glu Asn Asn Ser Ser
        1210                1215                1220

 gcg gta act gct cag aga atc att cca ctg aaa gct tta aaa cga gga     3809
 Ala Val Thr Ala Gln Arg Ile Ile Pro Leu Lys Ala Leu Lys Arg Gly
    1225                1230                1235

 tat cga cat ctt cag ctg cga aac ctt cac aat gaa gtc ttg gag att     3857
 Tyr Arg His Leu Gln Leu Arg Asn Leu His Asn Glu Val Leu Glu Ile
1240                1245                1250                1255

 tct agt tta ttc att aac agc aga agg atg gaa gaa aat tcc tct ggc     3905
 Ser Ser Leu Phe Ile Asn Ser Arg Arg Met Glu Glu Asn Ser Ser Gly
                1260                1265                1270

 aat acc atg tca gcc tct tcg atg ttt aat aca gaa gaa aga aaa tgt     3953
 Asn Thr Met Ser Ala Ser Ser Met Phe Asn Thr Glu Glu Arg Lys Cys
            1275                1280                1285

 ttg cag act cac aga gtc acg gtg cat ggg gtc cca ggg cca gag ccc     4001
 Leu Gln Thr His Arg Val Thr Val His Gly Val Pro Gly Pro Glu Pro
        1290                1295                1300

 ttt acc gtt ttc act att aat gga ggc acc aag gca aag cag ctt ctg     4049
 Phe Thr Val Phe Thr Ile Asn Gly Gly Thr Lys Ala Lys Gln Leu Leu
    1305                1310                1315

 cag caa att ctg aca aat gaa caa gac atc aaa cct gtt acc aca gac     4097
 Gln Gln Ile Leu Thr Asn Glu Gln Asp Ile Lys Pro Val Thr Thr Asp
1320                1325                1330                1335

 tat ttt ttg atg gaa gaa aaa tat ttt ata tct aaa gaa aag aat gaa     4145
 Tyr Phe Leu Met Glu Glu Lys Tyr Phe Ile Ser Lys Glu Lys Asn Glu
                1340                1345                1350

 tgt agg aaa caa cca ttc cag aga gcc att ggt cca gaa gag gag atc     4193
 Cys Arg Lys Gln Pro Phe Gln Arg Ala Ile Gly Pro Glu Glu Glu Ile
            1355                1360                1365

 atg caa att tta agc agc tgg ttt cca gaa gag gga tac atg ggc agg     4241
 Met Gln Ile Leu Ser Ser Trp Phe Pro Glu Glu Gly Tyr Met Gly Arg
        1370                1375                1380

 att gtc tta aaa acc cag cag gaa aac cta gaa gag aaa aac att gtt     4289
 Ile Val Leu Lys Thr Gln Gln Glu Asn Leu Glu Glu Lys Asn Ile Val
    1385                1390                1395

 caa gat gac aaa gag gtg atc ttg agc tca gag gag gag agt ttc ttt     4337
 Gln Asp Asp Lys Glu Val Ile Leu Ser Ser Glu Glu Glu Ser Phe Phe
1400                1405                1410                1415

 gtc caa gtg cat gat gtt tct cca gag caa cct cga aca gtc atc aaa     4385
 Val Gln Val His Asp Val Ser Pro Glu Gln Pro Arg Thr Val Ile Lys
                1420                1425                1430

 gca ccc cgc gtc agc act gca cag gat gtc att cag cag acc tta tgc     4433
 Ala Pro Arg Val Ser Thr Ala Gln Asp Val Ile Gln Gln Thr Leu Cys
            1435                1440                1445

 aaa gcc aaa tat tcc tac agc atc ctg agc aac ccc aat cca agc gac     4481
 Lys Ala Lys Tyr Ser Tyr Ser Ile Leu Ser Asn Pro Asn Pro Ser Asp
        1450                1455                1460

 tat gtg ctt ttg gaa gag gtg gtg aaa gac act acc aac aag aag act     4529
 Tyr Val Leu Leu Glu Glu Val Val Lys Asp Thr Thr Asn Lys Lys Thr
    1465                1470                1475

 acc aca cca aag tcc tct cag cgg gtc ctt ctg gat cag gag tgt gtg     4577
 Thr Thr Pro Lys Ser Ser Gln Arg Val Leu Leu Asp Gln Glu Cys Val
1480                1485                1490                1495

 ttt caa gcc caa agc aag tgg aaa ggt gca gga aaa ttc atc ctt aag     4625
 Phe Gln Ala Gln Ser Lys Trp Lys Gly Ala Gly Lys Phe Ile Leu Lys
                1500                1505                1510

 cta aag gag cag gtg cag gca tct cga gaa gat aaa aag aaa ggc att     4673
 Leu Lys Glu Gln Val Gln Ala Ser Arg Glu Asp Lys Lys Lys Gly Ile
            1515                1520                1525

 tct ttc gca agt gaa ctc aag aag ctc acc aag tca act aaa cag ccc     4721
 Ser Phe Ala Ser Glu Leu Lys Lys Leu Thr Lys Ser Thr Lys Gln Pro
        1530                1535                1540

 cga gga ctt aca tca cct tct cag ctc ttg acc tca gaa agt atc caa     4769
 Arg Gly Leu Thr Ser Pro Ser Gln Leu Leu Thr Ser Glu Ser Ile Gln
    1545                1550                1555

 acc aag gag gag aaa cct gtg ggt ggc ttg tcc tcc agt gac aca atg     4817
 Thr Lys Glu Glu Lys Pro Val Gly Gly Leu Ser Ser Ser Asp Thr Met
1560                1565                1570                1575

 gat tac cga cag tga ctaagggcag catgtttaac ccaggtgaag atctttaacc     4872
 Asp Tyr Arg Gln 


 aagaagttaa agagtgaaca tggtggaaaa aatataatta ttttcatcag acttaaactg   4932

 gaaattgatg atttctgaag ccttcacaca tgtgagatcc atgctgagga gaagcaaaat   4992

 ggcacagggc tagttgccac caaccaattt actgatgaat gaagcccagg ggactgccat   5052

 tttataaatg tcagcagttg gaaaaatcgt cacgaattga cttagagcaa gggtcagcaa   5112

 gcttgtctgt aaagggccaa acagtaaata ttttagggct gggggccata aaatatgttg   5172

 caaccaccca attctgccat tgtagtgcaa aagcagccat agacaacaca tacatgaacg   5232

 aacgtggctg tattccaata aaactttatt tatggacact g                       5273




      <210> 71
      <211> 2767
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1224)

      <400> 71
  atg gac ggg ctg ccc ggt cgg gcg ctg ggg gcc gcc tgc ctt ctg ctg      48
  Met Asp Gly Leu Pro Gly Arg Ala Leu Gly Ala Ala Cys Leu Leu Leu
    1               5                  10                  15

 ctg gcg gcc ggc tgg ctg ggg cct gag gcc tgg ggc tca ccc acg ccc       96
 Leu Ala Ala Gly Trp Leu Gly Pro Glu Ala Trp Gly Ser Pro Thr Pro
              20                  25                  30

 ccg ccg acg cct gcc gcg ccg ccg cca ccc ccg cca ccc gga gcc ccg      144
 Pro Pro Thr Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ala Pro
          35                  40                  45

 ggt ggc tcg cag gac acc tgt acg tcg tgc ggc ggc ttc cgg cgg cca      192
 Gly Gly Ser Gln Asp Thr Cys Thr Ser Cys Gly Gly Phe Arg Arg Pro
      50                  55                  60

 gag gag ctc ggc cga gtg gac ggc gac ttc ctg gag gcg gtg aag cgg      240
 Glu Glu Leu Gly Arg Val Asp Gly Asp Phe Leu Glu Ala Val Lys Arg
  65                  70                  75                  80

 cac atc ttg agc cgc ctg cag atg cgg ggc cgg ccc aac atc acg cac      288
 His Ile Leu Ser Arg Leu Gln Met Arg Gly Arg Pro Asn Ile Thr His
                  85                  90                  95

 gcc gtg cct aag gcc gcc atg gtc acg gcc ctg cgc aag ctg cac gcg      336
 Ala Val Pro Lys Ala Ala Met Val Thr Ala Leu Arg Lys Leu His Ala
             100                 105                 110

 ggc aag gtg cgc gag gac ggc cgc gtg gag atc ccg cac ctc gac ggc      384
 Gly Lys Val Arg Glu Asp Gly Arg Val Glu Ile Pro His Leu Asp Gly
         115                 120                 125

 cac gcc agc ccg ggc gcc gac ggc cag gag cgc gtt tcc gaa atc atc      432
 His Ala Ser Pro Gly Ala Asp Gly Gln Glu Arg Val Ser Glu Ile Ile
     130                 135                 140

 agc ttc gcc gag aca gat ggc ctc gcc tcc tcc cgg gtc cgc cta tac      480
 Ser Phe Ala Glu Thr Asp Gly Leu Ala Ser Ser Arg Val Arg Leu Tyr
 145                 150                 155                 160

 ttc ttc atc tcc aac gaa ggc aac cag aac ctg ttt gtg gtc cag gcc      528
 Phe Phe Ile Ser Asn Glu Gly Asn Gln Asn Leu Phe Val Val Gln Ala
                 165                 170                 175

 agc ctg tgg ctt tac ctg aaa ctc ctg ccc tac gtc ctg gag aag ggc      576
 Ser Leu Trp Leu Tyr Leu Lys Leu Leu Pro Tyr Val Leu Glu Lys Gly
             180                 185                 190

 agc cgg cgg aag gtg cgg gtc aaa gtg tac ttc cag gag cag ggc cac      624
 Ser Arg Arg Lys Val Arg Val Lys Val Tyr Phe Gln Glu Gln Gly His
         195                 200                 205

 ggt gac agg tgg aac atg gtg gag aag agg gtg gac ctc aag cgc agc      672
 Gly Asp Arg Trp Asn Met Val Glu Lys Arg Val Asp Leu Lys Arg Ser
     210                 215                 220

 ggc tgg cat acc ttc cca ctc acg gag gcc atc cag gcc ttg ttt gag      720
 Gly Trp His Thr Phe Pro Leu Thr Glu Ala Ile Gln Ala Leu Phe Glu
 225                 230                 235                 240

 cgg ggc gag cgg cga ctc aac cta gac gtg cag tgt gac agc tgc cag      768
 Arg Gly Glu Arg Arg Leu Asn Leu Asp Val Gln Cys Asp Ser Cys Gln
                 245                 250                 255

 gag ctg gcc gtg gtg ccg gtg ttc gtg gac cca ggc gaa gag tcg cac      816
 Glu Leu Ala Val Val Pro Val Phe Val Asp Pro Gly Glu Glu Ser His
             260                 265                 270

 cga ccc ttt gtg gtg gtg cag gct cgg ctg ggc gac agc agg cac cgc      864
 Arg Pro Phe Val Val Val Gln Ala Arg Leu Gly Asp Ser Arg His Arg
         275                 280                 285

 att cgc aag cga ggc ctg gag tgc gat ggc cgg acc aac ctc tgt tgc      912
 Ile Arg Lys Arg Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys
     290                 295                 300

 agg caa cag ttc ttc att gac ttc cgc ctc atc ggc tgg aac gac tgg      960
 Arg Gln Gln Phe Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp
 305                 310                 315                 320

 atc ata gca ccc acc ggc tac tac ggc aac tac tgt gag ggc agc tgc     1008
 Ile Ile Ala Pro Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys
                 325                 330                 335

 cca gcc tac ctg gca ggg gtc ccc ggc tct gcc tcc tcc ttc cac acg     1056
 Pro Ala Tyr Leu Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr
             340                 345                 350

 gct gtg gtg aac cag tac cgc atg cgg ggt ctg aac ccc ggc acg gtg     1104
 Ala Val Val Asn Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val
         355                 360                 365

 aac tcc tgc tgc att ccc acc aag ctg agc acc atg tcc atg ctg tac     1152
 Asn Ser Cys Cys Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr
     370                 375                 380

 ttc gat gat gag tac aac atc gtc aag cgg gac gtg ccc aac atg att     1200
 Phe Asp Asp Glu Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile
 385                 390                 395                 400

 gtg gag gag tgc ggc tgc gcc tga cagtgcaagg caggggcacg gtggtggggc    1254
 Val Glu Glu Cys Gly Cys Ala 
                 405

 acggagggca gtcccgggtg ggcttcttcc agcccccgcg ggaacggggg tacacggtgg   1314

 gctgagtaca gtcattctgt tgggctgtgg agatagtgcc agggtgcggc ctgagatatt   1374

 tttctacagc ttcatagagc aaccagtcaa aaccagagcg agaaccctca actgacatga   1434

 aatactttaa aatgcacacg tagccacgca cagccagacg catcctgcca cccacacagc   1494

 agcctccagg ataccagcaa atggatgcgg tgacaaatgg cagcttagct acaaatgcct   1554

 gtcagtcgga gagaatgggg tgagcagcca ccattcccac cagctggccc ggccacgtct   1614

 cgaagttgcg ccttcccgag cacacataaa agcacaaaga cagagacgca gagagagaga   1674

 gagagccacg gagaggaaaa gcagatgcag gggtggggag cgcagctcgg cggaggctgc   1734

 gtgtgccccg tggcttttac caggcctgct ctgcctggct cgatgtctgc ttcttcccca   1794

 gcctgggatc cttcgtgctt caaggcctgg ggagcctgtc cttccatgcc cttgtcgagg   1854

 gaaagagacc cagaaaggac acaacccgtc agagacctgg gagcaggggc aatgaccgtt   1914

 tgactgtttg tggcttgggc ctctgacatg acttatgtgt gtgtgtgttt ttggggtggg   1974

 gagggaggga gagaagaggg ggctaaattt gatgctttaa ctgatctcca acagttgaca   2034

 ggtcatcctt gccagttgta taactgaaaa aggacttttc taccaggtat gaccttttaa   2094

 gtgaaaatct gaattgttct aaatggaaag aaaaaaagtt gcaatctgtg cccttcattg   2154

 gggacattcc tctaggactg gtttggggac gggtgggaat gacccctagg caaggggatg   2214

 agaccgcagg aggaaatggc ggggaggagg cattcttgaa ctgctgagga tggggggtgt   2274

 cccctcagcg gaggccaagg gaggggagca gcctagttgg tcttggagag atggggaagg   2334

 ctttcagctg atttgcagaa gttgcccatg tgggccccag ccatcagggc tggccgtgga   2394

 cgtggcccct gcccactcac ctgcccgcct gcccgcccgc ccgcatagca cttgcagacc   2454

 tgcctgaacg cacatgacat agcacttgcc gatctgcgtg tgtccagaag tggcccttgg   2514

 ccgagcgccg aactcgctcg ccctctagat gtccaagtgc cacgtgaact atgcaattta   2574

 aagggttgac ccacactaga cgaaactgga ctcgtacgac tctttttata ttttttatac   2634

 ttgaaatgaa atcctttgct tcttttttaa gcgaatgatt gcttttaatg tttgcactga   2694

 tttagttgca tgattagtca gaaactgcca tttgaaaaaa agttattttt atagcagcaa   2754

 aaaaaaaaaa aaa                                                      2767




      <210> 72
      <211> 1494
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1293)

      <220>
      <221> misc_feature
      <222> (1)...(1494)
      <223> n = a,t,c or g

      <400> 72
 tctcctgatt taccgggccg accgacgcgt ccgggcctcc gatggctccg gattcgttac     60

 tggcgagcc    atg gcg ctg ggg gtg ggg cgc gca agg ccg ggc ctt tcc     108
              Met Ala Leu Gly Val Gly Arg Ala Arg Pro Gly Leu Ser
                1               5                  10

 tgt gga gtc atc tca ccg ccg tgc gca ccc act cgt aac tcg cac ccg      156
 Cys Gly Val Ile Ser Pro Pro Cys Ala Pro Thr Arg Asn Ser His Pro
      15                  20                  25

 ggt cct ggc tgc acc gca tcc cct cct gca ccc cct gga tgg ccc ttc      204
 Gly Pro Gly Cys Thr Ala Ser Pro Pro Ala Pro Pro Gly Trp Pro Phe
  30                  35                  40                  45

 agc caa cgg ggg cct ggg cga tgg tcg acc acg gag ctg cgc aag gaa      252
 Ser Gln Arg Gly Pro Gly Arg Trp Ser Thr Thr Glu Leu Arg Lys Glu
                  50                  55                  60

 aag tcc cgg gat gcg gcc cgc agc cgg cgc agc cag gag acc gag gtg      300
 Lys Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Gln Glu Thr Glu Val
              65                  70                  75

 ctg tac cag ctg gct cac acg ctg ccc ttc gcc cgc ggc gtc agc gcc      348
 Leu Tyr Gln Leu Ala His Thr Leu Pro Phe Ala Arg Gly Val Ser Ala
          80                  85                  90

 cac ctg gac aag gcc tct atc atg cgc ctc acc atc agc tac ctg cgc      396
 His Leu Asp Lys Ala Ser Ile Met Arg Leu Thr Ile Ser Tyr Leu Arg
      95                 100                 105

 atg cac cgc ctc tgc gcc gca ggg gag tgg aac cag gtg gga gca ggg      444
 Met His Arg Leu Cys Ala Ala Gly Glu Trp Asn Gln Val Gly Ala Gly
 110                 115                 120                 125

 gga gaa cca ctg gat gcc tgc tac ctg aag gcc ctg gag ggc ttc gtc      492
 Gly Glu Pro Leu Asp Ala Cys Tyr Leu Lys Ala Leu Glu Gly Phe Val
                 130                 135                 140

 atg gtg ctc acc gcc gag gga gac atg gct tac ctg tcg gag aat gtc      540
 Met Val Leu Thr Ala Glu Gly Asp Met Ala Tyr Leu Ser Glu Asn Val
             145                 150                 155

 agc aaa cac ctg ggc ctc agt cag ctg gag ctc att gga cac agc atc      588
 Ser Lys His Leu Gly Leu Ser Gln Leu Glu Leu Ile Gly His Ser Ile
         160                 165                 170

 ttt gat ttc atc cac ccc tgt gac caa gag gag ctt cag gac gcc ctg      636
 Phe Asp Phe Ile His Pro Cys Asp Gln Glu Glu Leu Gln Asp Ala Leu
     175                 180                 185

 acc ccc cag cag acc ctg tcc agg agg aag gtg gag gcc ccc acg gag      684
 Thr Pro Gln Gln Thr Leu Ser Arg Arg Lys Val Glu Ala Pro Thr Glu
 190                 195                 200                 205

 cgg tgc ttc tcc ttg cgc atg aag agt acg ctc acc agc cgc ggg cgc      732
 Arg Cys Phe Ser Leu Arg Met Lys Ser Thr Leu Thr Ser Arg Gly Arg
                 210                 215                 220

 acc ctc aac ctc aag gcg gcc acc tgg aag gtg ctg aac tgc tct gga      780
 Thr Leu Asn Leu Lys Ala Ala Thr Trp Lys Val Leu Asn Cys Ser Gly
             225                 230                 235

 cat atg agg gcc tac aag cca cct gcg cag act tct cca gct ggg agc      828
 His Met Arg Ala Tyr Lys Pro Pro Ala Gln Thr Ser Pro Ala Gly Ser
         240                 245                 250

 cct gac tca gag ccc ccg ctg cag tgc ctg gtg ctc atc tgc gaa gcc      876
 Pro Asp Ser Glu Pro Pro Leu Gln Cys Leu Val Leu Ile Cys Glu Ala
     255                 260                 265

 atc ccc cac cca ggc agc ctg gag ccc cca ctg ggc cga ggg gcc ttc      924
 Ile Pro His Pro Gly Ser Leu Glu Pro Pro Leu Gly Arg Gly Ala Phe
 270                 275                 280                 285

 ctc agc cgc cac agc ctg gac atg aag ttc acc tac tgt gac gac agg      972
 Leu Ser Arg His Ser Leu Asp Met Lys Phe Thr Tyr Cys Asp Asp Arg
                 290                 295                 300

 att gca gaa gtg gct ggc tat agt ccc gat gac ctg atc ggc tgt tcc     1020
 Ile Ala Glu Val Ala Gly Tyr Ser Pro Asp Asp Leu Ile Gly Cys Ser
             305                 310                 315

 gcc tac gag tac atc cac gcg ctg gac tcc gac gcg gtc agc aag agc     1068
 Ala Tyr Glu Tyr Ile His Ala Leu Asp Ser Asp Ala Val Ser Lys Ser
         320                 325                 330

 atc cac acc tgt atg tat ccc att tcc cca ggt gcg aag cca gct gcc     1116
 Ile His Thr Cys Met Tyr Pro Ile Ser Pro Gly Ala Lys Pro Ala Ala
     335                 340                 345

 aca tgg ccc cca gct gac acc agg acc ccc cag ctc ccc ata ccc cag     1164
 Thr Trp Pro Pro Ala Asp Thr Arg Thr Pro Gln Leu Pro Ile Pro Gln
 350                 355                 360                 365

 gat gca ctg cct ccc cac ctc aac acc agc tcc ctg ctc ccc aag ccc     1212
 Asp Ala Leu Pro Pro His Leu Asn Thr Ser Ser Leu Leu Pro Lys Pro
                 370                 375                 380

 caa gga act gtc tcc ttc ctt gcc ccc tca tac cca gtc ccc aga tct     1260
 Gln Gly Thr Val Ser Phe Leu Ala Pro Ser Tyr Pro Val Pro Arg Ser
             385                 390                 395

 ttc tct ccc cat ttg ccc cct tgg tgg ccc tga tccctccc gatccccctc     1311
 Phe Ser Pro His Leu Pro Pro Trp Trp Pro 
         400                 405

 ctcagtgctg agcaagggcc aggcagtaac agggcagtat cgcttcctgg cccggagtgg   1371

 tggctacctg tggacccaga cccaggccac agtggtgtca gggggacggg gcccccagtc   1431

 ggagagtatc gtctgtntcc attttttaat caggtaagca ggaggngggg ctggggtggc   1491

 tgt                                                                 1494




      <210> 73
      <211> 1388
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(1387)

      <400> 73
 cgggacctgg ggcggagagc ggttcgcgcg cttcgggcct agtccggact cgccgccgcc     60

 gccgccatat tcccgtggca tcttccttac tttgtccatc ctccggactc gcgatcttcc    120

 ttccggagcc   atg tca gaa gga gtg gac ttg att gat ata tat gct gac     169
              Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp
                1               5                  10

 gag gag ttc aac cag gac cca gag ttc aac aat aca gat cag att gac      217
 Glu Glu Phe Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp
      15                  20                  25

 ctg tat gat gat gtg ctg aca gcc acc tca cag ccc tca gat gac aga      265
 Leu Tyr Asp Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg
  30                  35                  40                  45

 agc agc agc act gaa cca cct cct cct gtt cgc cag gag cca tct ccc      313
 Ser Ser Ser Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro
                  50                  55                  60

 aag ccc aac aac aag acc cct gca att ctg tat acc tac agt ggc ctg      361
 Lys Pro Asn Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu
              65                  70                  75

 cgt aat aga cga gct gcc gtt tat gtg ggc agc ttc tcc tgg tgg acc      409
 Arg Asn Arg Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr
          80                  85                  90

 aca gac cag cag ctg atc cag gtt att cgc tct ata gga gtc tat gat      457
 Thr Asp Gln Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp
      95                 100                 105

 gtg gtg gag ttg aaa ttt gca gag aat cga gca aat ggc cag tcc aaa      505
 Val Val Glu Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys
 110                 115                 120                 125

 ggg tat gct gag gtg gtg gta gcc tct gaa aac tct gtc cac aaa ttg      553
 Gly Tyr Ala Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu
                 130                 135                 140

 ttg gaa ctc cta cca ggg aaa gtt ctt aat gga gaa aaa gtg gac gtg      601
 Leu Glu Leu Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val
             145                 150                 155

 agg ccg gcc acc cgg cag aac ctg tca cag ttt gag gca cag gct cgg      649
 Arg Pro Ala Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg
         160                 165                 170

 aaa cgt gag tgt gtc cga gtc cca aga ggg gga ata cct cca cgg gcc      697
 Lys Arg Glu Cys Val Arg Val Pro Arg Gly Gly Ile Pro Pro Arg Ala
     175                 180                 185

 cat tcc cga gat tct agt gat tct gct gat gga cgg gcc aca ccc tct      745
 His Ser Arg Asp Ser Ser Asp Ser Ala Asp Gly Arg Ala Thr Pro Ser
 190                 195                 200                 205

 gag aac ctt gta ccc tca tct gct cgt gtg gat aag ccc ccc agt gtg      793
 Glu Asn Leu Val Pro Ser Ser Ala Arg Val Asp Lys Pro Pro Ser Val
                 210                 215                 220

 ctg ccc tac ttc aat cgt cct cct tcg gcc ctt ccc ctg atg ggt ctg      841
 Leu Pro Tyr Phe Asn Arg Pro Pro Ser Ala Leu Pro Leu Met Gly Leu
             225                 230                 235

 ccc cca cca cca att cca ccc cca cca cct ctc tcc tca agc ttt ggg      889
 Pro Pro Pro Pro Ile Pro Pro Pro Pro Pro Leu Ser Ser Ser Phe Gly
         240                 245                 250

 gtc cct cct cct cct cct ggt atc cac tac cag cat ctc atg ccc cca      937
 Val Pro Pro Pro Pro Pro Gly Ile His Tyr Gln His Leu Met Pro Pro
     255                 260                 265

 cct cct cga tta cct cct cat ctt gct gta cct ccc cct ggg gcc atc      985
 Pro Pro Arg Leu Pro Pro His Leu Ala Val Pro Pro Pro Gly Ala Ile
 270                 275                 280                 285

 cca cct gcc ctt cac ctc aat cca gcc ttc ctt ccg ccg cca aac gct     1033
 Pro Pro Ala Leu His Leu Asn Pro Ala Phe Leu Pro Pro Pro Asn Ala
                 290                 295                 300

 aca gtg ggg cct cca cca gat act tac atg aag gcc tct gcc ccc tat     1081
 Thr Val Gly Pro Pro Pro Asp Thr Tyr Met Lys Ala Ser Ala Pro Tyr
             305                 310                 315

 aac cac cat ggc agc cga gat tcg ggc cct cca ccc tct aca gtg agt     1129
 Asn His His Gly Ser Arg Asp Ser Gly Pro Pro Pro Ser Thr Val Ser
         320                 325                 330

 gaa gcc gaa ttt gaa gat atc atg aag cga aac aga gca att tcc agc     1177
 Glu Ala Glu Phe Glu Asp Ile Met Lys Arg Asn Arg Ala Ile Ser Ser
     335                 340                 345

 agt gcc att tcc aaa gca gta tct gga gcc agt gca ggg gat tac agt     1225
 Ser Ala Ile Ser Lys Ala Val Ser Gly Ala Ser Ala Gly Asp Tyr Ser
 350                 355                 360                 365

 gac gca att gag acg ctg ctc aca gcc att gcg gtt atc aaa cag tcc     1273
 Asp Ala Ile Glu Thr Leu Leu Thr Ala Ile Ala Val Ile Lys Gln Ser
                 370                 375                 380

 cgg gtt gcc aat gat gag cgt tgc cgt gtc ctc atc tcc tct ctt aag     1321
 Arg Val Ala Asn Asp Glu Arg Cys Arg Val Leu Ile Ser Ser Leu Lys
             385                 390                 395

 gac tgt ctt cat ggc atc gaa gcc aag tcc tac agt gtg ggt gcc agt     1369
 Asp Cys Leu His Gly Ile Glu Ala Lys Ser Tyr Ser Val Gly Ala Ser
         400                 405                 410

 ggg agc tct tcc agg tga g                                           1388
 Gly Ser Ser Ser Arg 
     415





      <210> 74
      <211> 2184
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(2124)

      <400> 74
 cgcgcgctgc ctgaggacgc cgcggccccc gcccccgcc   atg ggc gcc cct gcc      54
                                              Met Gly Ala Pro Ala
                                                1               5

 tgc gcc ctc gcg ctc tgc gtg gcc gtg gcc atc gtg gcc ggc gcc tcc      102
 Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile Val Ala Gly Ala Ser
                  10                  15                  20

 tcg gag tcc ttg ggg acg gag cag cgc gtc gtg ggg cga gcg gca gaa      150
 Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu
              25                  30                  35

 gtc ccg ggc cca gag ccc ggc cag cag gag cag ttg gtc ttc ggc agc      198
 Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser
          40                  45                  50

 ggg gat gct gtg gag ctg agc tgt ccc ccg ccc ggg ggt ggt ccc atg      246
 Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met
      55                  60                  65

 ggg ccc act gtc tgg gtc aag gat ggc aca ggg ctg gtg ccc tcg gag      294
 Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu
  70                  75                  80                  85

 cgt gtc ctg gtg ggg ccc cag cgg ctg cag gtg ctg aat gcc tcc cac      342
 Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His
                  90                  95                 100

 gag gac tcc ggg gcc tac agc tgc cgg cag cgg ctc acg cag cgc gta      390
 Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val
             105                 110                 115

 ctg tgc cac ttc agt gtg cgg gtg aca gac gct cca tcc tcg gga gat      438
 Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp
         120                 125                 130

 gac gaa gac ggg gag gac gag gct gag gac aca ggt gtg gac aca ggg      486
 Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly
     135                 140                 145

 gcc cct tac tgg aca cgg ccc gag cgg atg gac aag aag ctg ctg gcc      534
 Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala
 150                 155                 160                 165

 gtg ccg gcc gcc aac acc gtc cgc ttc cgc tgc cca gcc gct ggc aac      582
 Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn
                 170                 175                 180

 ccc act ccc tcc atc tcc tgg ctg aag aac ggc agg gag ttc cgc ggc      630
 Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly
             185                 190                 195

 gag cac cgc att gga ggc atc aag ctg cgg cat cag cag tgg agc ctg      678
 Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu
         200                 205                 210

 gtc atg gaa agc gtg gtg ccc tcg gac cgc ggc aac tac acc tgc gtc      726
 Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val
     215                 220                 225

 gtg gag aac aag ttt ggc agc atc cgg cag acg tac acg ctg gac gtg      774
 Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val
 230                 235                 240                 245

 ctg gag cgc tcc ccg cac cgg ccc atc ctg cag gcg ggg ctg ccg gcc      822
 Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala
                 250                 255                 260

 aac cag acg gcg gtg ctg ggc agc gac gtg gag ttc cac tgc aag gtg      870
 Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val
             265                 270                 275

 tac agt gac gca cag ccc cac atc cag tgg ctc aag cac gtg gag gtg      918
 Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val
         280                 285                 290

 aac ggc agc aag gtg ggc ccg gac ggc aca ccc tac gtt acc gtg ctc      966
 Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu
     295                 300                 305

 aag gtg tcc ctg gag tcc aac gcg tcc atg agc tcc aac aca cca ctg     1014
 Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu
 310                 315                 320                 325

 gtg cgc atc gca agg ctg tcc tca ggg gag ggc ccc acg ctg gcc aat     1062
 Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn
                 330                 335                 340

 gtc tcc gag ctc gag ctg cct gcc gac ccc aaa tgg gag ctg tct cgg     1110
 Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg
             345                 350                 355

 gcc cgg ctg acc ctg ggc aag ccc ctt ggg gag ggc tgc ttc ggc cag     1158
 Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln
         360                 365                 370

 gtg gtc atg gcg gag gcc atc ggc att gac aag gac cgg gcc gcc aag     1206
 Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys
     375                 380                 385

 cct gtc acc gta gcc gtg aag atg ctg aaa gac gat gcc act gac aag     1254
 Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys
 390                 395                 400                 405

 gac ctg tcg gac ctg gtg tct gag atg gag atg atg aag atg atc ggg     1302
 Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly
                 410                 415                 420

 aaa cac aaa aac atc atc aac ctg ctg ggc gcc tgc acg cag ggc ggg     1350
 Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly
             425                 430                 435

 ccc ctg tac gtg ctg gtg gag tac gcg gcc aag ggt aac ctg cgg gag     1398
 Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu
         440                 445                 450

 ttt ctg cgg gcg cgg cgg ccc ccg ggc ctg gac tac tcc ttc gac acc     1446
 Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr
     455                 460                 465

 tgc aag ccg ccc gag gag cag ctc acc ttc aag gac ctg gtg tcc tgt     1494
 Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys
 470                 475                 480                 485

 gcc tac cag gtg gcc cgg ggc atg gag tac ttg gcc tcc cag aag tgc     1542
 Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys
                 490                 495                 500

 atc cac agg gac ctg gct gcc cgc aat gtg ctg gtg acc gag gac aac     1590
 Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn
             505                 510                 515

 gtg atg aag atc gca gac ttc ggg ctg gcc cgg gac gtg cac aac ctc     1638
 Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu
         520                 525                 530

 gac tac tac aag aag aca acc aac ggc cgg ctg ccc gtg aag tgg atg     1686
 Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met
     535                 540                 545

 gcg cct gag gcc ttg ttt gac cga gtc tac act cac cag agt gac gtc     1734
 Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val
 550                 555                 560                 565

 tgg tcc ttt ggg gtc ctg ctc tgg gag atc ttc acg ctg ggg ggc tcc     1782
 Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser
                 570                 575                 580

 ccg tac ccc ggc atc cct gtg gag gag ctc ttc aag ctg ctg aag gag     1830
 Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu
             585                 590                 595

 ggc cac cgc atg gac aag ccc gcc aac tgc aca cac gac ctg tac atg     1878
 Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met
         600                 605                 610

 atc atg cgg gag tgc tgg cat gcc gcg ccc tcc cag agg ccc acc ttc     1926
 Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe
     615                 620                 625

 aag cag ctg gtg gag gac ctg gac cgt gtc ctt acc gtg acg tcc acc     1974
 Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr
 630                 635                 640                 645

 gac gag tac ctg gac ctg tcg gcg cct ttc gag cag tac tcc ccg ggt     2022
 Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly
                 650                 655                 660

 ggc cag gac acc ccc agc tcc agc tcc tca ggg gac gac tcc gtg ttt     2070
 Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe
             665                 670                 675

 gcc cac gac ctg ctg ccc ccg gcc cca ccc agc agt ggg ggc tcg cgg     2118
 Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg
         680                 685                 690

 acg tga agggccactg gtccccaaca atgtgagggg tccctagcag ccctccctgc      2174
 Thr 


 tgctggtgca                                                          2184




      <210> 75
      <211> 806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (487)..(648)

      <400> 75
 ctctgacttc tggcttgcat tgtttccagt gagaaatctg ctactatttt tatcttagtg     60

 tctctgtagt gtgtcttggt tgcttttagg attttctctt ttcattggcc ttgagtccct    120

 ccttcttccc ctcacatgtg gggactttta attccatgta tattaggctg catgaagctt    180

 ccccacaacc tactgatgct cttttcatta gaaacatttc ttactctgcg tttcattttg    240

 gatagtttct attcctatgt tttcaaaccc accaataaaa gattctgcaa catctgacct    300

 gccattaatc ccgtccagtg tatttttcat ctcctgtatt gtagttttca tctctacaat    360

 ccagcttgag cctttggtta tatcttccat gttgctcctg cactgtttga acatgcagaa    420

 tggctagtgg ggcagtgagc tgaggagaag ggacagaggg gaagctcggc tgttgggtct    480

 acgggt   atg atg gag acc atg cag ctg aaa gta aac cgt cac ccc ttc     528
          Met Met Glu Thr Met Gln Leu Lys Val Asn Arg His Pro Phe
            1               5                  10

 tgc ttc agt gtg aaa ggc cag gtg aag atg ctg cag ctg atg agg ctg      576
 Cys Phe Ser Val Lys Gly Gln Val Lys Met Leu Gln Leu Met Arg Leu
  15                  20                  25                  30

 ggc ctt agg gtg cgg ggg gtg gtg gaa tct gct tgt ggg cgg gag atg      624
 Gly Leu Arg Val Arg Gly Val Val Glu Ser Ala Cys Gly Arg Glu Met
                  35                  40                  45

 tgg cta tgt ggc tat aaa gga tga agatgaacgc cctgtttgct tttcagcctc     678
 Trp Leu Cys Gly Tyr Lys Gly 
              50

 gcttggatca aggttaaaag gccggttgtg gccttcttgg tggaagaaag agagagataa    738

 ggcactgtcc tccccttcgg agggtctggg gatacactaa tccatcaaaa ccactgaggg    798

 ctgggcgt                                                             806




      <210> 76
      <211> 357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(208)

      <400> 76
 gcaagagagg ggaaccagag aggacccaga ggggagagac agagcagcaa gcagtggatt     60

 gctccttgac gacgccagc atg agc tcc ttc tcc acc acc acc gtg agc ttc     112
                      Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe
                        1               5                  10

 ctc ctt tta ctg gca ttc cag ctc cta ggt cag acc aga gct aat ccc      160
 Leu Leu Leu Leu Ala Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro
              15                  20                  25

 atg tac aat gcc gtg tcc aac gca gac ctg tta ctg aaa gtg gtt tga      208
 Met Tyr Asn Ala Val Ser Asn Ala Asp Leu Leu Leu Lys Val Val 
          30                  35                  40

 aagtgaataa acttcagcac catggacaga agacaaatgc ctgcgttggt gtgctttctt    268

 tcttcttggg aagagaattc aggccgatat tccttgtcgt tttactcttt gtcagaggaa    328

 agaatgctga gtttttcttc ttcctttca                                      357




      <210> 77
      <211> 1297
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(949)

      <400> 77
 cgcccggaat tcccgggtcg aggcacgcgt tcgatttaga atcctgcagc accccaccat     60

 ctaagagcaa gagccaaag atg ttt gtc ttg ctc tat gtt aca agt ttt gcc     112
                      Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala
                        1               5                  10

 att tgt gcc agt gga caa ccc cgg ggt aat cag ttg aaa gga gag aac      160
 Ile Cys Ala Ser Gly Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn
              15                  20                  25

 tac tcc ccc agg tat atc tgc agc att cct ggc ttg cct gga cct cca      208
 Tyr Ser Pro Arg Tyr Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro
          30                  35                  40

 ggg ccc cct gga gca aat ggt tcc cct ggg ccc cat ggt cgc atc ggc      256
 Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly
      45                  50                  55

 ctt cca gga aga gat ggt aga gac ggc agg aaa gga gag aaa ggt gaa      304
 Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu
  60                  65                  70                  75

 aag gga act gca ggt ttg aga ggt aag act gga ccg cta ggt ctt gcc      352
 Lys Gly Thr Ala Gly Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala
                  80                  85                  90

 ggt gag aaa ggg gac caa gga gag act ggg aag aaa gga ccc ata gga      400
 Gly Glu Lys Gly Asp Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly
              95                 100                 105

 cca gag gga gag aaa gga gaa gta ggt cca att ggt cct cct gga cca      448
 Pro Glu Gly Glu Lys Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro
         110                 115                 120

 aag gga gac aga gga gaa caa ggg gac ccg ggg ctg cct gga gtt tgc      496
 Lys Gly Asp Arg Gly Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys
     125                 130                 135

 aga tgt gga agc atc gtg ctc aaa tcc gcc ttt tct gtt ggc atc aca      544
 Arg Cys Gly Ser Ile Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr
 140                 145                 150                 155

 acc agc tac cca gaa gaa aga cta cct att ata ttt aac aag gtc ctc      592
 Thr Ser Tyr Pro Glu Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu
                 160                 165                 170

 ttc aac gag gga gag cac tac aac cct gcc aca ggg aag ttc atc tgt      640
 Phe Asn Glu Gly Glu His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys
             175                 180                 185

 gct ttc cca ggg atc tat tac ttt tct tat gat atc aca ttg gct aat      688
 Ala Phe Pro Gly Ile Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn
         190                 195                 200

 aag cat ctg gca atc gga ctg gta cac aat ggg caa tac cgg ata aag      736
 Lys His Leu Ala Ile Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys
     205                 210                 215

 acc ttc gac gcc aac aca gga aac cat gat gtg gct tcg ggg tcc aca      784
 Thr Phe Asp Ala Asn Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr
 220                 225                 230                 235

 gtc atc tat ctg cag cca gaa gat gaa gtc tgg ctg gag att ttc ttc      832
 Val Ile Tyr Leu Gln Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe
                 240                 245                 250

 aca gac cag aat ggc ctc ttc tca gac cca ggt tgg gca gac agc tta      880
 Thr Asp Gln Asn Gly Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu
             255                 260                 265

 ttc tcc ggg ttt ctc tta tac gtt gac aca gat tac cta gat tcc ata      928
 Phe Ser Gly Phe Leu Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile
         270                 275                 280

 tca gaa gat gat gaa ttg tga tc aggaccaaga tccctgtggt aaacactctg      981
 Ser Glu Asp Asp Glu Leu 
     285

 attgaatctg gggttccaga aggtggaaca agcaggaatg ggatccaaag agactcccac   1041

 tcagattcta aagcatttaa agacaattct agcagaattt atcaaaacaa gatgaaacac   1101

 agaaaagttg aaaccacaac aaaatgaatt ctattaaaga atagccccag atataaattc   1161

 tcttgaaagc aatgttcata aatatttaag caaattaaag acaatgttaa caaattttct   1221

 attaaatgcc ctgagtgata aaaccagttg gcaataatat tgccttatta aatcttcaaa   1281

 aaataaaaaa aaaaaa                                                   1297




      <210> 78
      <211> 943
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(701)

      <400> 78
 gcattcccgg gtcgactacg ctgtgcacga gcgcccgcta taagacgact gactatacgc     60

 gactccgccc gcctccccat tcactgggaa ctaacacccg gcgccgctca gacatctcta    120

 ttcccgcctc tccgacccgg tctcacttcg ctcctgggca gctgcgcgga gaactggggc    180

 tcaccgtc atg gat gct cta tca gaa gca aat ggc aca ttt gca tta aac     230
          Met Asp Ala Leu Ser Glu Ala Asn Gly Thr Phe Ala Leu Asn
            1               5                  10

 ctt ttg aaa aag cta ggg gaa aac aac tca aac aac tta ttt ttt tcc      278
 Leu Leu Lys Lys Leu Gly Glu Asn Asn Ser Asn Asn Leu Phe Phe Ser
  15                  20                  25                  30

 cca ctg agc ata tca tca gcc ttg gcc atg gtt ttc atg ggg gca aag      326
 Pro Leu Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys
                  35                  40                  45

 gga aac act gca gct cag atg tct cag gca ctt tgt ttt agt aaa atc      374
 Gly Asn Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Phe Ser Lys Ile
              50                  55                  60

 gga ggt gaa gat gga gat att cat cga ggt ttt cag tca ctt ctt gtt      422
 Gly Gly Glu Asp Gly Asp Ile His Arg Gly Phe Gln Ser Leu Leu Val
          65                  70                  75

 gca att aac aga act gac act gaa tat gtg ctt aga act gcc aac ggg      470
 Ala Ile Asn Arg Thr Asp Thr Glu Tyr Val Leu Arg Thr Ala Asn Gly
      80                  85                  90

 ctc ttt gga gaa aag tct tat gat ttc ctc aca ggt ttt aca gat tcc      518
 Leu Phe Gly Glu Lys Ser Tyr Asp Phe Leu Thr Gly Phe Thr Asp Ser
  95                 100                 105                 110

 tgt ggc aaa ttt tac caa gca acg ata aaa cag cta gac ttt gtg aat      566
 Cys Gly Lys Phe Tyr Gln Ala Thr Ile Lys Gln Leu Asp Phe Val Asn
                 115                 120                 125

 gat aca gag aag tcc aca aca cgt gta aac tcc tgg gtt gct gat aaa      614
 Asp Thr Glu Lys Ser Thr Thr Arg Val Asn Ser Trp Val Ala Asp Lys
             130                 135                 140

 act aaa ggt gaa aat ata ttg tta ttc tat ttc gat aat att tta aac      662
 Thr Lys Gly Glu Asn Ile Leu Leu Phe Tyr Phe Asp Asn Ile Leu Asn
         145                 150                 155

 agt ttt ata gtc agt tct tta caa aac tgt caa ata taa aaaggagtcc       711
 Ser Phe Ile Val Ser Ser Leu Gln Asn Cys Gln Ile 
     160                 165                 170

 ttttttctct aaacaactat gcaaacatta aaacctttct ttggaaatat agccaactcg    771

 agtccttttc tctagctata gcttttccct tatcaagtat ctgtgatgtc tctctagatg    831

 aaataatctc ttgcaggttt ttcacttgtt aatattaggt agtacttctt atcacaaata    891

 gcgtgtaaga taggaagtta acgaatcgtt gacagcgaag tcgacccggg aa            943




      <210> 79
      <211> 1370
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (302)..(940)

      <400> 79
 tcgggtctat ccacgcatcc gaacacaagc caggtgagtc ttcatgctgg tgtttaaaag     60

 tttcctccac atcagtatag ccacgctgat gtctactctg ttgaagccag gtgcgcagtg    120

 atctactgac taatggattc tccaattgtt aagcctatgt tacaggacaa aggccgtcgc    180

 tttgtaaaag cttgaagtgc agtttgctgc tgagtacaga agacctttgc aaacagagag    240

 gggagatttt ctctgtaagg ttgcaaacaa gagcaggtcc tggaagataa gattccccgc    300

 c    atg tta tcc tcc gtg gtg ttt tgg gga cta att gcc ctc att ggc     346
      Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly
        1               5                  10                  15

 act tcc agg ggc tca tac ccc ttc agt cac tca atg aag cct cac cta      394
 Thr Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu
                  20                  25                  30

 cat cca cgc ctg tac cac ggc tgc tat ggg gac atc atg acc atg aag      442
 His Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys
              35                  40                  45

 acc tct ggg gcc act tgt gat gca aac agt gtg atg aac tgc ggg atc      490
 Thr Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile
          50                  55                  60

 cgt ggt tct gaa atg ttt gct gag atg gat ttg agg gcc ata aaa cct      538
 Arg Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro
      65                  70                  75

 tac cag act ctg atc aaa gaa gtc ggg cag aga cat tgc gtg gac cct      586
 Tyr Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro
  80                  85                  90                  95

 gct gtc atc gca gcc atc atc tcc agg gaa agc cat ggc gga tct gtc      634
 Ala Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val
                 100                 105                 110

 ctg caa gac ggc tgg gac cac agg gga ctt aaa ttt ggc ttg atg cag      682
 Leu Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln
             115                 120                 125

 ctt gat aaa caa acg tac cac cct gtc ggt gcc tgg gat agc aaa gag      730
 Leu Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu
         130                 135                 140

 cac ctt tca cag gct act ggg att cta aca gag aga att aag gca atc      778
 His Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile
     145                 150                 155

 cag aaa aaa ttc ccc acg tgg agt gtt gct cag cac ctc aaa ggt ggt      826
 Gln Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Gly
 160                 165                 170                 175

 ctc tca gct ttt aag tca gga att gaa gcg att gcc acc cca tcg gac      874
 Leu Ser Ala Phe Lys Ser Gly Ile Glu Ala Ile Ala Thr Pro Ser Asp
                 180                 185                 190

 ata gac aat gac ttc gtc aat gat atc att gct cga gct aag ttc tat      922
 Ile Asp Asn Asp Phe Val Asn Asp Ile Ile Ala Arg Ala Lys Phe Tyr
             195                 200                 205

 aaa aga caa agc ttc tag gcaaag ctctgtgggt gggccaggtt ggcagagtgc      976
 Lys Arg Gln Ser Phe 
         210

 tcagatggcc gcctttgaga gttttacgtg aatgtgttgt atacaacact ggcacagaaa   1036

 tgattaaaat catgaaagaa aattcatttc ccaattttct gaatgaaaat aatcattgaa   1096

 aaaaggaaag aaaaataaaa gaaatccatc cagttcacaa tatggttcct aggaaacgga   1156

 catagacata tatataacta ctttgcagta aatgtgaata tcatggcaaa tggtccctag   1216

 gtattccagc caggcttcat tttagcctgt gattccaatg cccacctact ccctgtctac   1276

 cagaattgct aacaagttaa gtaagcctta cccgagcctt tgtctttttt ccagtatctg   1336

 cccagagccc tcaagctttg cttatgagaa gttc                               1370




      <210> 80
      <211> 1960
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(1906)

      <400> 80
 taagcttgcg gccgcttcgt accgcgtcct gagccgcctc cttggctatg gagaggcggc     60

 ccccgagcca ggccctccgc caccgccccc gggccatggc cccccgccgc cacccttcct    120

 cgcgcggccc ggcccgcggg gctcccggcc gccgcagctg  atg gtg ttc cgc aac     175
                                              Met Val Phe Arg Asn
                                                1               5

 gtg ggt cgg ccg ccg gag gag gag gac gtg gag gcg gcc ccg gag ccg      223
 Val Gly Arg Pro Pro Glu Glu Glu Asp Val Glu Ala Ala Pro Glu Pro
                  10                  15                  20

 gga ccc tcg gaa ctg ctg tgt ccc cgg cac cgc tgt gcc ctg gac ccc      271
 Gly Pro Ser Glu Leu Leu Cys Pro Arg His Arg Cys Ala Leu Asp Pro
              25                  30                  35

 aag gcc ctg ccg ccg ggc ttg gcg ctc gag cgg acc tgg ggc ccg gcg      319
 Lys Ala Leu Pro Pro Gly Leu Ala Leu Glu Arg Thr Trp Gly Pro Ala
          40                  45                  50

 gct gga cta gag gcg cag ttg gcg gct ctg ggg ctc ggg cag ccg gcg      367
 Ala Gly Leu Glu Ala Gln Leu Ala Ala Leu Gly Leu Gly Gln Pro Ala
      55                  60                  65

 ggg ccg ggg gtc aag aca gtc ggt ggg ggt tgc tgc ccg tgt ccg tgt      415
 Gly Pro Gly Val Lys Thr Val Gly Gly Gly Cys Cys Pro Cys Pro Cys
  70                  75                  80                  85

 ccc cct cag ccg ccc cct ccg cag ccc cag ccg cct gct gcc gcc ccg      463
 Pro Pro Gln Pro Pro Pro Pro Gln Pro Gln Pro Pro Ala Ala Ala Pro
                  90                  95                 100

 cag gcc ggg gag gac ccc acg gaa acg agc gac gcg ctg ctg gtc ctg      511
 Gln Ala Gly Glu Asp Pro Thr Glu Thr Ser Asp Ala Leu Leu Val Leu
             105                 110                 115

 gag ggc ttg gaa tcg gag gcc gag agc ctg gag act aac agc tgc tcg      559
 Glu Gly Leu Glu Ser Glu Ala Glu Ser Leu Glu Thr Asn Ser Cys Ser
         120                 125                 130

 gaa gag gag ctc agc agc ccg ggt cgc gga gga gga ggg ggc ggc cgg      607
 Glu Glu Glu Leu Ser Ser Pro Gly Arg Gly Gly Gly Gly Gly Gly Arg
     135                 140                 145

 ctt ctg ctg cag ccc cca ggc cct gaa tta cct ccg gtg ccc ttc ccg      655
 Leu Leu Leu Gln Pro Pro Gly Pro Glu Leu Pro Pro Val Pro Phe Pro
 150                 155                 160                 165

 ctg cag gac ttg gtc cct ctg ggg cgc ctg agt aga ggg gag cag cag      703
 Leu Gln Asp Leu Val Pro Leu Gly Arg Leu Ser Arg Gly Glu Gln Gln
                 170                 175                 180

 cag cag cag cag cag caa cct ccc ccg ccc ccg cct cct ccc ggg ccc      751
 Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro
             185                 190                 195

 ctc cgg cca ctc gcg ggt cct tct cgg aag ggc tcc ttc aaa atc cgc      799
 Leu Arg Pro Leu Ala Gly Pro Ser Arg Lys Gly Ser Phe Lys Ile Arg
         200                 205                 210

 ctc agt cgc ctc ttt cgc acc aag agc tgc aac ggt ggc tcc ggc ggt      847
 Leu Ser Arg Leu Phe Arg Thr Lys Ser Cys Asn Gly Gly Ser Gly Gly
     215                 220                 225

 ggg gat ggg acc ggc aag agg cct tct gga gag ctg gct gct tca gct      895
 Gly Asp Gly Thr Gly Lys Arg Pro Ser Gly Glu Leu Ala Ala Ser Ala
 230                 235                 240                 245

 gcg agc ctg aca gac atg gga ggc tct gcg ggc cgg gag ctg gac gcg      943
 Ala Ser Leu Thr Asp Met Gly Gly Ser Ala Gly Arg Glu Leu Asp Ala
                 250                 255                 260

 ggg agg aaa ccc aag ttg aca aga act caa agt gcc ttt tct ccg gtc      991
 Gly Arg Lys Pro Lys Leu Thr Arg Thr Gln Ser Ala Phe Ser Pro Val
             265                 270                 275

 tcc ttc agc ccc ctg ttc aca ggt gaa act gtg tcg ctt gtg gat gtg     1039
 Ser Phe Ser Pro Leu Phe Thr Gly Glu Thr Val Ser Leu Val Asp Val
         280                 285                 290

 gac att tct cag cgg ggc ctg acc tct cca cac cct cca act ccc cct     1087
 Asp Ile Ser Gln Arg Gly Leu Thr Ser Pro His Pro Pro Thr Pro Pro
     295                 300                 305

 cct cct ccg aga aga agc ctc agc ctc cta gat gat atc agt ggg acg     1135
 Pro Pro Pro Arg Arg Ser Leu Ser Leu Leu Asp Asp Ile Ser Gly Thr
 310                 315                 320                 325

 ctg cct aca tct gtc ctt gtg gct ccg atg ggg tct tcc ttg cag tct     1183
 Leu Pro Thr Ser Val Leu Val Ala Pro Met Gly Ser Ser Leu Gln Ser
                 330                 335                 340

 ttc ccc cta cct ccg cct cct cca ccc cat gcc cca gat gca ttt ccc     1231
 Phe Pro Leu Pro Pro Pro Pro Pro Pro His Ala Pro Asp Ala Phe Pro
             345                 350                 355

 cgg att gct ccc atc cga gca gct gaa tcc ctg cac agc caa ccc cca     1279
 Arg Ile Ala Pro Ile Arg Ala Ala Glu Ser Leu His Ser Gln Pro Pro
         360                 365                 370

 cag cac ctc cag tgt ccc ctc tac cgg cct gac tcg agc agc ttt gca     1327
 Gln His Leu Gln Cys Pro Leu Tyr Arg Pro Asp Ser Ser Ser Phe Ala
     375                 380                 385

 gcc agc ctt cga gag ttg gag aag tgt ggt tgg tat tgg ggg cca atg     1375
 Ala Ser Leu Arg Glu Leu Glu Lys Cys Gly Trp Tyr Trp Gly Pro Met
 390                 395                 400                 405

 aat tgg gaa gat gca gag atg aag ctg aaa ggg aaa cca gat ggt tct     1423
 Asn Trp Glu Asp Ala Glu Met Lys Leu Lys Gly Lys Pro Asp Gly Ser
                 410                 415                 420

 ttc ctg gta cga gac agt tct gat cct cgt tac atc ctg agc ctc agt     1471
 Phe Leu Val Arg Asp Ser Ser Asp Pro Arg Tyr Ile Leu Ser Leu Ser
             425                 430                 435

 ttc cga tca cag ggt atc acc cac cac act aga atg gag cac tac aga     1519
 Phe Arg Ser Gln Gly Ile Thr His His Thr Arg Met Glu His Tyr Arg
         440                 445                 450

 gga acc ttc agc ctg tgg tgt cat ccc aag ttt gag gac cgc tgt caa     1567
 Gly Thr Phe Ser Leu Trp Cys His Pro Lys Phe Glu Asp Arg Cys Gln
     455                 460                 465

 tct gtt gta gag ttt att aag aga gcc att atg cac tcc aag aat gga     1615
 Ser Val Val Glu Phe Ile Lys Arg Ala Ile Met His Ser Lys Asn Gly
 470                 475                 480                 485

 aag ttt ctc tat ttc tta aga tcc agg gtt cca gga ctg cca cca act     1663
 Lys Phe Leu Tyr Phe Leu Arg Ser Arg Val Pro Gly Leu Pro Pro Thr
                 490                 495                 500

 cct gtc cag ctg ctc tat cca gtg tcc cga ttc agc aat gtc aaa tcc     1711
 Pro Val Gln Leu Leu Tyr Pro Val Ser Arg Phe Ser Asn Val Lys Ser
             505                 510                 515

 ctc cag cac ctt tgc aga ttc cgg ata cga cag ctc gtc agg ata gat     1759
 Leu Gln His Leu Cys Arg Phe Arg Ile Arg Gln Leu Val Arg Ile Asp
         520                 525                 530

 cac atc cca gat ctc cca ctg cct aaa cct ctg atc tct tat atc cga     1807
 His Ile Pro Asp Leu Pro Leu Pro Lys Pro Leu Ile Ser Tyr Ile Arg
     535                 540                 545

 aag ttc tac tac tat gat cct cag gaa gag gta tac ctg tct cta aag     1855
 Lys Phe Tyr Tyr Tyr Asp Pro Gln Glu Glu Val Tyr Leu Ser Leu Lys
 550                 555                 560                 565

 gaa gcg cag ctc att tcc aaa cag aag caa gag gtg gaa ccc tcc acg     1903
 Glu Ala Gln Leu Ile Ser Lys Gln Lys Gln Glu Val Glu Pro Ser Thr
                 570                 575                 580

 tag cgag gggctccctg ctggtcacca ccaagggcat ttggttgcca agctccagct     1960
 






      <210> 81
      <211> 1774
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (313)..(576)

      <400> 81
 gggtcgaccc acgcgtccgg ctttctattg tatgccacag ttttgcactt ttttgcttta     60

 gtatatataa tgcttatgta atatagaatg gatctccaat gatttttttg tgtgtttttc    120

 acatatttgg catatgtgtg tgatactgct cagtgccagg catctcttac acacagtagt    180

 caagaatctt ttttggcctc tgcctaacca gattcctcct gcctccaggt agattttata    240

 cttatttcaa ggcagaaact tggtggaagg aggtaatctg tcgctaatgt gtatttattc    300

 cttcatgcat gt    atg cat tca tac cct ggg att ttt ttc ttc cct tta     348
                  Met His Ser Tyr Pro Gly Ile Phe Phe Phe Pro Leu
                    1               5                  10

 gct gtg ttc cag atc atc tcc ctg gta att tac ccc gtg aag tac acc      396
 Ala Val Phe Gln Ile Ile Ser Leu Val Ile Tyr Pro Val Lys Tyr Thr
          15                  20                  25

 cag acc ttc acc ctt cac gat aac cct gct gtt aat tac atc tat aac      444
 Gln Thr Phe Thr Leu His Asp Asn Pro Ala Val Asn Tyr Ile Tyr Asn
      30                  35                  40

 tgg gcc tat ggc ttc gga tgg gcg gcc acc atc atc ttg att ggt tgt      492
 Trp Ala Tyr Gly Phe Gly Trp Ala Ala Thr Ile Ile Leu Ile Gly Cys
  45                  50                  55                  60

 tcc ttc ttc ttc tgc tgc ctc ccc aac tac gag gat gac ctt ttg ggg      540
 Ser Phe Phe Phe Cys Cys Leu Pro Asn Tyr Glu Asp Asp Leu Leu Gly
                  65                  70                  75

 gcc gcc aag ccc agg tac ttc tat ccc cca gcc taa tgtg ggaggaagag      590
 Ala Ala Lys Pro Arg Tyr Phe Tyr Pro Pro Ala 
              80                  85

 cctgagaaaa gcctgctgca agatggatct gaggaggaaa ctgttctcca aggcacaagg    650

 aacctacgtt tgggcaatgt tcatatgatc agaaatgcta gaataaatgc taaagaaaat    710

 tcttcataat tagtgttaag tttcatgtat gtcgtgtgga gttaaaaaga cttgaattct    770

 gtttgctaag tatatgctaa tttttcctta tgtcaattct ataccattta agcttcattt    830

 gttaaagaat atgcctgtga aacttgataa ggtagaaatg tagcagcctc tcatttaata    890

 atctgatggg gcttctgttt ttccacatag aatgggttgt ttctgctaag ggctacagag    950

 gaggaaagtc actggcaaaa cttccgtgac caaatatcct gaaattagta tttttttaaa   1010

 aagaccttat tttgagtttt cagttacata aaaaagcaga agcagattgg tttcctaagt   1070

 gagcatcgtt tgtgagaatt tttagtcagt gttttgaaca attattgttt ttctaagctt   1130

 cgtgttgact ttctctgatg cgtagaaaag tgttctaacg tagccaaggt taagccgctg   1190

 tcactactga aatgctaaga attttcctct tttcccgtag tgtagagggg tagggtgtgg   1250

 gaagaagccg tgttagcaca tctgtagtat tctgtgtgta tgcttagaac cagcgtagac   1310

 cggatgggag gatggactag gcctaatccc tcccaactgg tggatgtgaa gaggtcaggt   1370

 aggaaggcac aggagggtca ccactgtcac agcagtgcca tgcagacatc ctaggagaag   1430

 acatggcagt gtttcttctc agtgcttctt cccttaactg agctctgctc acagacagct   1490

 agaatagatt ttaactgtaa cagaaaccta aatgtaatta aaacctggtc ttccttggta   1550

 agcagactta aaatatctgt atagtacatg caagtggaaa atttgggaat gcgtgtctct   1610

 gaatacatac cggaagggct actattacct tttccttacc atttatactt acctaatgga   1670

 aacgagcttg ttttaactat cagaacacta ttttgtaagg tgctgcaaag acagttgaag   1730

 ttttcattac caacttcccc aataaaccag gtgttcaaaa aaaa                    1774




      <210> 82
      <211> 1870
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(672)

      <400> 82
 tttagtcgcg gtgtcagcgc tcgcaggacc actcttggcc gctgctcctg cccggcgttc     60

 ctccgctccg cgcccgccgc caccgacgac     atg ctg cgc tgc ggc ctg gcc     111
                                      Met Leu Arg Cys Gly Leu Ala
                                        1               5

 tgc gag cgc tgc agg tgg atc ctg ccc ctg ctg ctc ctc agc gcc atc      159
 Cys Glu Arg Cys Arg Trp Ile Leu Pro Leu Leu Leu Leu Ser Ala Ile
          10                  15                  20

 gcc ttc gac atc atc gcg ctg gcc ggc cgc ggc tgg ctg cag tct agc      207
 Ala Phe Asp Ile Ile Ala Leu Ala Gly Arg Gly Trp Leu Gln Ser Ser
      25                  30                  35

 aac cac atc cag aca tcg tcg ctt tgg tgg agg tgt ttc gac gag ggc      255
 Asn His Ile Gln Thr Ser Ser Leu Trp Trp Arg Cys Phe Asp Glu Gly
  40                  45                  50                  55

 ggc ggc agc ggc tcc tac gac gat ggc tgc cag agc ctc atg gag tac      303
 Gly Gly Ser Gly Ser Tyr Asp Asp Gly Cys Gln Ser Leu Met Glu Tyr
                  60                  65                  70

 gca tgg gga cga gca gct gca gcc acg ctt ttc tgt ggc ttt atc atc      351
 Ala Trp Gly Arg Ala Ala Ala Ala Thr Leu Phe Cys Gly Phe Ile Ile
              75                  80                  85

 ctg tgc atc tgc ttc att ctc tcg ttc ttc gcc ctg tgt gga ccc cag      399
 Leu Cys Ile Cys Phe Ile Leu Ser Phe Phe Ala Leu Cys Gly Pro Gln
          90                  95                 100

 atg ctt gtt ttc ctg aga gtc att gga ggc ctc ctc gca ctg gct gcc      447
 Met Leu Val Phe Leu Arg Val Ile Gly Gly Leu Leu Ala Leu Ala Ala
     105                 110                 115

 ata ttc cag atc atc tcc ctg gta att tac ccc gtg aag tac acc cag      495
 Ile Phe Gln Ile Ile Ser Leu Val Ile Tyr Pro Val Lys Tyr Thr Gln
 120                 125                 130                 135

 acc ttc acc ctt cac gat aac cct gct gtt aat tac atc tat aac tgg      543
 Thr Phe Thr Leu His Asp Asn Pro Ala Val Asn Tyr Ile Tyr Asn Trp
                 140                 145                 150

 gcc tat ggc ttc gga tgg gcg gcc acc atc atc ttg att ggt tgt tcc      591
 Ala Tyr Gly Phe Gly Trp Ala Ala Thr Ile Ile Leu Ile Gly Cys Ser
             155                 160                 165

 ttc ttc ttc tgc tgc ctc ccc aac tac gag gat gac ctt ttg ggg gcc      639
 Phe Phe Phe Cys Cys Leu Pro Asn Tyr Glu Asp Asp Leu Leu Gly Ala
         170                 175                 180

 gcc aag ccc agg tac ttc tat ccc cca gcc taa tgtgggag gaagagcctg      690
 Ala Lys Pro Arg Tyr Phe Tyr Pro Pro Ala 
     185                 190

 agaaaagcct gctgcaagat ggatctgagg aggaaactgt tctccaaggc acaaggaacc    750

 tacgtttggg caatgttcat atgatcagaa atgctagaat aaatgctaaa gaaaattctt    810

 cataattagt gttaagtttc atgtatgtcg tgtggagtta aaaagacttg aattctgttt    870

 gctaagtata tgctaatttt tccttatgtc aattctatac catttaagct tcatttgtta    930

 aagaatatgc ctgtgaaact tgataaggta gaaatgtagc agcctctcat ttaataatct    990

 gatggggctt ctgtttttcc acatagaatg ggttgtttct gctaagggct acagaggagg   1050

 aaagtcactg gcaaaacttc cgtgaccaaa tatcctgaaa ttagtatttt tttaaaaaga   1110

 ccttattttg agttttcagt tacataaaaa agcagaagca gattggtttc ctaagtgagc   1170

 atcgtttgtg agaattttta gtcagtgttt tgaacaatta ttgtttttct aagcttcgtg   1230

 ttgactttct ctgatgcgta gaaaagtgtt ctaacgtagc caaggttaag ccgctgtcac   1290

 tactgaaatg ctaagaattt tcctcttttc ccgtagtgta gaggggtagg gtgtgggaag   1350

 aagccgtgtt agcacatctg tagtattctg tgtgtatgct tagaaccagc gtagaccgga   1410

 tgggaggatg gactaggcct aatccctccc aactggtgga tgtgaagagg tcaggtagga   1470

 aggcacagga gggtcaccac tgtcacagca gtgccatgca gacatcctag gagaagacat   1530

 ggcagtgttt cttctcagtg cttcttccct taactgagct ctgctcacag acagctagaa   1590

 tagattttaa ctgtaacaga aacctaaatg taattaaaac ctggtcttcc ttggtaagca   1650

 gacttaaaat atctgtatag tacatgcaag tggaaaattt gggaatgcgt gtctctgaat   1710

 acataccgga agggctacta ttaccttttc cttaccattt atacttacct aatggaaacg   1770

 agcttgtttt aactatcaga acactatttt gtaaggtgct gcaaagacag ttgaagtttt   1830

 cattaccaac ttccccaata aaccaggtgt tcaaaaaaaa                         1870




      <210> 83
      <211> 1294
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (647)..(910)

      <400> 83
 acttcgtgcg gggattccag tttccaaata gctgtgcttt ctgaaagccc tataaactga     60

 aaacttgatg tttcagcagg cgctgcctct aagcccccga ctctcaccgg aggaaataaa    120

 taggaaacct taagctaaaa taagtaacca agagagaatt actcatccta ttcagtctca    180

 cccctacctc atcaaatact tttatcgttc ctacctctcc ttttaagcca aatattaaaa    240

 ctttttaatg gaaattattt actacgccac ccgtgtggga attgctttac tcactctact    300

 atttgcagta ggactatata ctgtagcacc ctcagggtaa aatatcagac acagaatctc    360

 aattaccata gcatttcgct taattattat cctcatagcg ggaataatgg ttactaacag    420

 aaaataacac atgggccttt ccaaaccagc acctctgcct cttattagga aaggaatgtt    480

 gtttctatat cagccaatca gacctagtaa aaagcgctat taaaaaaaac aagctaaaaa    540

 gctaaggagt accaaaacaa acaaacagat tcttggtttg ggaacaaaat catagatagc    600

 atgggtcatc ccattcctgg gccctctcct aataatatac ctaatt   atg gga cta     655
                                                      Met Gly Leu
                                                        1

 atg ttc tta ccc tgc cta att aac ctt ttt cag aga ttt ttt aaa ctg      703
 Met Phe Leu Pro Cys Leu Ile Asn Leu Phe Gln Arg Phe Phe Lys Leu
       5                  10                  15

 aca gga tca tgg cca ttt cac aga caa cta ccc aaa aat atc tac aga      751
 Thr Gly Ser Trp Pro Phe His Arg Gln Leu Pro Lys Asn Ile Tyr Arg
  20                  25                  30                  35

 cgg cac tgc tcc tac caa cac gat acc aga gaa ctc tct gtc ccc tcg      799
 Arg His Cys Ser Tyr Gln His Asp Thr Arg Glu Leu Ser Val Pro Ser
                  40                  45                  50

 tca gca gga agt agc cag aaa gaa cat gcc gcc cct cgt cct ttt tat      847
 Ser Ala Gly Ser Ser Gln Lys Glu His Ala Ala Pro Arg Pro Phe Tyr
              55                  60                  65

 aac tat gag gtc tgg att gac aga gca gaa gca tca cca ttg tgg ata      895
 Asn Tyr Glu Val Trp Ile Asp Arg Ala Glu Ala Ser Pro Leu Trp Ile
          70                  75                  80

 agc gcc tca ttt taa aattcacctt aatcaaaaac tgcctaaatc caaagggcat      950
 Ser Ala Ser Phe 
      85

 cagcctaatg gctaaggtca gcatgatcac aaaccacaaa taacatctcc aaccaaaaac   1010

 attccagaca cctcccacag agaaatgcta gcctcgggat aacccctctc ctgccggaaa   1070

 gatgtcaccc ccaagataac cacccctccg cccagaacat tccaaccctg ccacaaactt   1130

 ctcccccaca cagaaacatt ccaagcttgt aataagctcc ctcaccctaa aaccaacgta   1190

 cattcttagt ctgcaaggaa aagtgctcct gactgaccag ccagaatcct ctctcaggtc   1250

 ttttctataa taaacctgtc tttgactgtc aaaaaaaaaa aaaa                    1294




      <210> 84
      <211> 633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(399)

      <400> 84
 tgcacaagag agactgtttc ctggacggaa actgtggtct ccagatcttt ataataacat     60

 cacctctaat ctttaactca tgagcgttgt gctatacaga ctgttttctt gaggcagttt    120

 cttgtaagaa gtaaatgaag cttcctt    atg agt ctg tta aga ctc cat aga     171
                                  Met Ser Leu Leu Arg Leu His Arg
                                    1               5

 ttg tca ata ata tgg aaa aat ttg ata ttt cat cag gaa tat gaa cat      219
 Leu Ser Ile Ile Trp Lys Asn Leu Ile Phe His Gln Glu Tyr Glu His
      10                  15                  20

 gtg ttt cag gta gag aat gcc aaa gat aat gaa gat agt att cta caa      267
 Val Phe Gln Val Glu Asn Ala Lys Asp Asn Glu Asp Ser Ile Leu Gln
  25                  30                  35                  40

 aga gaa att cct gcc aga caa tcc cga aga aga ttt cgg aaa att aac      315
 Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe Arg Lys Ile Asn
                  45                  50                  55

 tat aaa gga gag cgc caa acc att act gat gat gtg gag gtt aac agc      363
 Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val Glu Val Asn Ser
              60                  65                  70

 tat ctt tct gtg agt ata ttt agg aac act tca tga atct tccttaattt      413
 Tyr Leu Ser Val Ser Ile Phe Arg Asn Thr Ser 
          75                  80

 tcatatctag tatctttaat ttacatgtat ctttggtaat atcaacatgc tgggctctgt    473

 atgtgaaaat ttggggcagg taaatatata atctttttaa atgcttctgt ttggttgaat    533

 tggttaggaa tgctcttacc agtgggaggt ctggttttgc ttttttgttg gtggctaaac    593

 agcgaaaaaa cctattaggc tggatgcacc gggtcatgcc                          633




      <210> 85
      <211> 2437
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(2172)

      <400> 85
 gtacacattc caaaaagaga ttgatacact tgcaatgaag ggttcttgct tgagggagcc     60

 aggagtcggg tttgtcttgc caatggaagt tggagtggag ccactcccga ctgtgtgcct    120

 gtcagatgtg ccaccccgcc acaactggcc aatggggtga cggaaggcct ggactatggc    180

 ttc  atg aag gaa gta aca ttc cac tgt cat gag ggc tac atc ttg cac     228
      Met Lys Glu Val Thr Phe His Cys His Glu Gly Tyr Ile Leu His
        1               5                  10                  15

 ggt gct cca aaa ctc acc tgt cag tca gat ggc aac tgg gat gca gag      276
 Gly Ala Pro Lys Leu Thr Cys Gln Ser Asp Gly Asn Trp Asp Ala Glu
                  20                  25                  30

 att cct ctc tgt aaa cca gtc aac tgt gga cct cct gaa gat ctt gcc      324
 Ile Pro Leu Cys Lys Pro Val Asn Cys Gly Pro Pro Glu Asp Leu Ala
              35                  40                  45

 cat ggt ttc cct aat ggt ttt tcc ttt att cat ggg ggc cat ata cag      372
 His Gly Phe Pro Asn Gly Phe Ser Phe Ile His Gly Gly His Ile Gln
          50                  55                  60

 tat cag tgc ttt cct ggt tat aag ctc cat gga aat tca tca aga agg      420
 Tyr Gln Cys Phe Pro Gly Tyr Lys Leu His Gly Asn Ser Ser Arg Arg
      65                  70                  75

 tgc ctc tcc aat ggc tcc tgg agt ggc agc tca cct tcc tgc ctg cct      468
 Cys Leu Ser Asn Gly Ser Trp Ser Gly Ser Ser Pro Ser Cys Leu Pro
  80                  85                  90                  95

 tgc aga tgt tcc aca cca gta att gaa tat gga act gtc aat ggg aca      516
 Cys Arg Cys Ser Thr Pro Val Ile Glu Tyr Gly Thr Val Asn Gly Thr
                 100                 105                 110

 gat ttt gac tgt gga aag gca gcc cgg att cag tgc ttc aaa ggc ttc      564
 Asp Phe Asp Cys Gly Lys Ala Ala Arg Ile Gln Cys Phe Lys Gly Phe
             115                 120                 125

 aag ctc cta gga ctt tct gaa atc acc tgt gaa gcc gat ggc cag tgg      612
 Lys Leu Leu Gly Leu Ser Glu Ile Thr Cys Glu Ala Asp Gly Gln Trp
         130                 135                 140

 agc tct ggg ttc cac cac ttt gaa cac act tct tgt ggt tct ctt cca      660
 Ser Ser Gly Phe His His Phe Glu His Thr Ser Cys Gly Ser Leu Pro
     145                 150                 155

 atg ata cca aat gcg ttc atc agt gag acc agc tct tgg aag gaa aat      708
 Met Ile Pro Asn Ala Phe Ile Ser Glu Thr Ser Ser Trp Lys Glu Asn
 160                 165                 170                 175

 gtg ata act tac agc tgc agg tct gga tat gtc ata caa ggc agt tca      756
 Val Ile Thr Tyr Ser Cys Arg Ser Gly Tyr Val Ile Gln Gly Ser Ser
                 180                 185                 190

 gat ctg att tgt aca gag aaa ggg gta tgg agc cag cct tat cca gtc      804
 Asp Leu Ile Cys Thr Glu Lys Gly Val Trp Ser Gln Pro Tyr Pro Val
             195                 200                 205

 tgt gag ccc ttg tcc tgt ggg tcc cca ccg tct gtc gcc aat gca gtg      852
 Cys Glu Pro Leu Ser Cys Gly Ser Pro Pro Ser Val Ala Asn Ala Val
         210                 215                 220

 gca act gga gag gca cac acc tat gaa agt gaa gtg aaa ctc aga tgt      900
 Ala Thr Gly Glu Ala His Thr Tyr Glu Ser Glu Val Lys Leu Arg Cys
     225                 230                 235

 ctg gaa ggt tat acg atg gat aca gat acc aga tca atc acc tgt cag      948
 Leu Glu Gly Tyr Thr Met Asp Thr Asp Thr Arg Ser Ile Thr Cys Gln
 240                 245                 250                 255

 aaa gat ggt cgc tgg ttc cct gag aga atc tcc tgc agt cct aaa aaa      996
 Lys Asp Gly Arg Trp Phe Pro Glu Arg Ile Ser Cys Ser Pro Lys Lys
                 260                 265                 270

 tgt cct ctc ccg gaa aac ata aca cat ata ctt gta cat ggg gac gat     1044
 Cys Pro Leu Pro Glu Asn Ile Thr His Ile Leu Val His Gly Asp Asp
             275                 280                 285

 ttc agt gtg aat agg caa gtt tct gtg tca tgt gca gaa ggg tat acc     1092
 Phe Ser Val Asn Arg Gln Val Ser Val Ser Cys Ala Glu Gly Tyr Thr
         290                 295                 300

 ttt gag gga gtt aac ata tca gta tgt cag ctt gat gga acc tgg gag     1140
 Phe Glu Gly Val Asn Ile Ser Val Cys Gln Leu Asp Gly Thr Trp Glu
     305                 310                 315

 cca cca ttc tcc gat gaa tct tgc agt cca gtt tct tgt ggg aaa cct     1188
 Pro Pro Phe Ser Asp Glu Ser Cys Ser Pro Val Ser Cys Gly Lys Pro
 320                 325                 330                 335

 gaa agt cca gaa cat gga ttt gtg gtt ggc agt aaa tac acc ttt gaa     1236
 Glu Ser Pro Glu His Gly Phe Val Val Gly Ser Lys Tyr Thr Phe Glu
                 340                 345                 350

 agc aca att att tat cag tgt gag cct ggc tat gaa cta gag ggg aac     1284
 Ser Thr Ile Ile Tyr Gln Cys Glu Pro Gly Tyr Glu Leu Glu Gly Asn
             355                 360                 365

 agg gaa cgt gtc tgc cag gag aac aga cag tgg agt gga ggg gtg gca     1332
 Arg Glu Arg Val Cys Gln Glu Asn Arg Gln Trp Ser Gly Gly Val Ala
         370                 375                 380

 ata tgc aaa gag acc agg tgt gaa act cca ctt gaa ttt ctc aat ggg     1380
 Ile Cys Lys Glu Thr Arg Cys Glu Thr Pro Leu Glu Phe Leu Asn Gly
     385                 390                 395

 aaa gct gac att gaa aac agg acg act gga ccc aac gtg gta tat tcc     1428
 Lys Ala Asp Ile Glu Asn Arg Thr Thr Gly Pro Asn Val Val Tyr Ser
 400                 405                 410                 415

 tgc aac aga ggc tac agt ctt gaa ggg cca tct gag gca cac tgc aca     1476
 Cys Asn Arg Gly Tyr Ser Leu Glu Gly Pro Ser Glu Ala His Cys Thr
                 420                 425                 430

 gaa aat gga acc tgg agc cac cca gtc cct ctc tgc aaa cca aat cca     1524
 Glu Asn Gly Thr Trp Ser His Pro Val Pro Leu Cys Lys Pro Asn Pro
             435                 440                 445

 tgc cct gtt cct ttt gtg att ccc gag aat gct ctg ctg tct gaa aag     1572
 Cys Pro Val Pro Phe Val Ile Pro Glu Asn Ala Leu Leu Ser Glu Lys
         450                 455                 460

 gag ttt tat gtt gat cag aat gtg tcc atc aaa tgt agg gaa ggt ttt     1620
 Glu Phe Tyr Val Asp Gln Asn Val Ser Ile Lys Cys Arg Glu Gly Phe
     465                 470                 475

 ctg ctg cag ggc cac ggc atc att acc tgc aac ccc gac gag acg tgg     1668
 Leu Leu Gln Gly His Gly Ile Ile Thr Cys Asn Pro Asp Glu Thr Trp
 480                 485                 490                 495

 aca cag aca agc gcc aaa tgt gaa aaa atc tca tgt ggt cca cca gct     1716
 Thr Gln Thr Ser Ala Lys Cys Glu Lys Ile Ser Cys Gly Pro Pro Ala
                 500                 505                 510

 cac gta gaa aat gca att gct cga ggc gta cat tat caa tat gga gac     1764
 His Val Glu Asn Ala Ile Ala Arg Gly Val His Tyr Gln Tyr Gly Asp
             515                 520                 525

 atg atc acc tac tca tgt tac agt gga tac atg ttg gag ggt ttc ctg     1812
 Met Ile Thr Tyr Ser Cys Tyr Ser Gly Tyr Met Leu Glu Gly Phe Leu
         530                 535                 540

 agg agt gtt tgt tta gaa aat gga aca tgg aca tca cct cct att tgc     1860
 Arg Ser Val Cys Leu Glu Asn Gly Thr Trp Thr Ser Pro Pro Ile Cys
     545                 550                 555

 aga gct gtc tgt cga ttt cca tgt cag aat ggg ggc atc tgc caa cgc     1908
 Arg Ala Val Cys Arg Phe Pro Cys Gln Asn Gly Gly Ile Cys Gln Arg
 560                 565                 570                 575

 cca aat gct tgt tcc tgt cca gag ggc tgg atg ggg cgc ctc tgt gaa     1956
 Pro Asn Ala Cys Ser Cys Pro Glu Gly Trp Met Gly Arg Leu Cys Glu
                 580                 585                 590

 gaa tta atc tgc att ctt ccc tgt ctg aac gga ggt cgc tgt gtg gcc     2004
 Glu Leu Ile Cys Ile Leu Pro Cys Leu Asn Gly Gly Arg Cys Val Ala
             595                 600                 605

 cct tac cag tgt gac tgc ccg cct ggc tgg acg ggg tct cgc tgt cat     2052
 Pro Tyr Gln Cys Asp Cys Pro Pro Gly Trp Thr Gly Ser Arg Cys His
         610                 615                 620

 aca gct gtt tgc cag tct ccc tgc tta aat ggt gga aaa tgt gta aga     2100
 Thr Ala Val Cys Gln Ser Pro Cys Leu Asn Gly Gly Lys Cys Val Arg
     625                 630                 635

 cca aac cga tgt cac tgt ctt tct tct tgg acg gga cat aac tgt tcc     2148
 Pro Asn Arg Cys His Cys Leu Ser Ser Trp Thr Gly His Asn Cys Ser
 640                 645                 650                 655

 agg aaa agg agg act ggg ttt taa ccactgcacg accatctggc tctcccaaaa    2202
 Arg Lys Arg Arg Thr Gly Phe 
                 660

 gcaggatcat ctctcctcgg tagtgcctgg gcatcctgga acttatgcaa agaaagtcca   2262

 acatggtgct gggtcttgtt tagtaaactt gttacttggg gttacttttt ttattttgtg   2322

 atatattttg ttattccttg tgacatactt tcttacatgt ttccattttt aaatatgcct   2382

 gtattttcta tataaaaatt atattaaata gatgctgcta caaaaaaaaa aaaaa        2437




      <210> 86
      <211> 5676
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(5622)

      <400> 86
 cacgaggcgt ccctcgcc  atg gcg cgg ctc gcg gac tac ttc gtg ctg gtg      51
                      Met Ala Arg Leu Ala Asp Tyr Phe Val Leu Val
                        1               5                  10

 gcg ttc ggg ccg cac ccg cgc ggg agt ggg gaa ggc cag ggc cag att       99
 Ala Phe Gly Pro His Pro Arg Gly Ser Gly Glu Gly Gln Gly Gln Ile
              15                  20                  25

 ctg cag cgc ttc cca gag aag gac tgg gag gac aac cca ttc ccc cag      147
 Leu Gln Arg Phe Pro Glu Lys Asp Trp Glu Asp Asn Pro Phe Pro Gln
          30                  35                  40

 ggc atc gag ctg ttt tgc cag ccc agc ggg tgg cag ctg tgt ccc gag      195
 Gly Ile Glu Leu Phe Cys Gln Pro Ser Gly Trp Gln Leu Cys Pro Glu
      45                  50                  55

 agg aat cca ccg acc ttc ttt gtt gct gtc ctc acc gac atc aac tcc      243
 Arg Asn Pro Pro Thr Phe Phe Val Ala Val Leu Thr Asp Ile Asn Ser
  60                  65                  70                  75

 gag cgc cac tac tgc gcc tgc ttg acc ttc tgg gag cca gcg gag cct      291
 Glu Arg His Tyr Cys Ala Cys Leu Thr Phe Trp Glu Pro Ala Glu Pro
                  80                  85                  90

 tca cag gaa acg acg cgc gtg gag gat gcc aca gag agg gag gaa gag      339
 Ser Gln Glu Thr Thr Arg Val Glu Asp Ala Thr Glu Arg Glu Glu Glu
              95                 100                 105

 ggg gat gag gga ggc cag acc cac ctg tct ccc aca gca cct gcc cca      387
 Gly Asp Glu Gly Gly Gln Thr His Leu Ser Pro Thr Ala Pro Ala Pro
         110                 115                 120

 tct gcc cag ctg ttt gca ccg aag acg ctg gta ctg gtg tcg cga ctc      435
 Ser Ala Gln Leu Phe Ala Pro Lys Thr Leu Val Leu Val Ser Arg Leu
     125                 130                 135

 gac cac acg gag gtg ttc agg aac agc ctt ggc ctc atc tat gcc atc      483
 Asp His Thr Glu Val Phe Arg Asn Ser Leu Gly Leu Ile Tyr Ala Ile
 140                 145                 150                 155

 cac gtg gag ggc ctg aat gtg tgc ctg gag aac gtg att ggg aac ctg      531
 His Val Glu Gly Leu Asn Val Cys Leu Glu Asn Val Ile Gly Asn Leu
                 160                 165                 170

 ctg acg tgc act gtg ccc ctg gct ggg ggc tcg cag agg acg atc tct      579
 Leu Thr Cys Thr Val Pro Leu Ala Gly Gly Ser Gln Arg Thr Ile Ser
             175                 180                 185

 ttg ggg gct ggt gac cgg cag gtc atc cag act cca ctg gcc gac tcg      627
 Leu Gly Ala Gly Asp Arg Gln Val Ile Gln Thr Pro Leu Ala Asp Ser
         190                 195                 200

 ctg ccc gtc agc cgc tgc agc gtg gcc ctg ctc ttc cgc cag cta ggc      675
 Leu Pro Val Ser Arg Cys Ser Val Ala Leu Leu Phe Arg Gln Leu Gly
     205                 210                 215

 atc acc aac gtg ctg tct ttg ttc tgt gcc gcc ctc acg gag cac aag      723
 Ile Thr Asn Val Leu Ser Leu Phe Cys Ala Ala Leu Thr Glu His Lys
 220                 225                 230                 235

 gtt ctc ttc ctg tcc cgg agc tac cag cgg ctc gcc gat gcc tgt agg      771
 Val Leu Phe Leu Ser Arg Ser Tyr Gln Arg Leu Ala Asp Ala Cys Arg
                 240                 245                 250

 ggc ctc ctg gca ctg ctg ttt cct ctc aga tac agc ttc acc tat gtg      819
 Gly Leu Leu Ala Leu Leu Phe Pro Leu Arg Tyr Ser Phe Thr Tyr Val
             255                 260                 265

 ccc atc ctg ccg gct cag ctg ctg gag gtc ctc agc aca ccc acg ccc      867
 Pro Ile Leu Pro Ala Gln Leu Leu Glu Val Leu Ser Thr Pro Thr Pro
         270                 275                 280

 ttc atc att ggg gtc aac gcg gcc ttc cag gca gag acc cag gag ctg      915
 Phe Ile Ile Gly Val Asn Ala Ala Phe Gln Ala Glu Thr Gln Glu Leu
     285                 290                 295

 ctc gat gtg att gtt gct gat ctg gat gga ggg acg gtc acc att cct      963
 Leu Asp Val Ile Val Ala Asp Leu Asp Gly Gly Thr Val Thr Ile Pro
 300                 305                 310                 315

 gag tgt gtg cac att cca ccc ttg cca gag cca ctg cag agt cag acg     1011
 Glu Cys Val His Ile Pro Pro Leu Pro Glu Pro Leu Gln Ser Gln Thr
                 320                 325                 330

 cac agt gtg ctg agc atg gtc ctg gac ccg gag ctg gag ttg gct gac     1059
 His Ser Val Leu Ser Met Val Leu Asp Pro Glu Leu Glu Leu Ala Asp
             335                 340                 345

 ctc gcc ttc cct ccg ccc acg aca tcc acc tcc tcc ctg aag atg cag     1107
 Leu Ala Phe Pro Pro Pro Thr Thr Ser Thr Ser Ser Leu Lys Met Gln
         350                 355                 360

 gac aag gag ctg cgc gcg gtc ttc ctg cgg ctg ttc gct cag ctg ctg     1155
 Asp Lys Glu Leu Arg Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Leu
     365                 370                 375

 cag ggc tat cgc tgg tgc ctg cac gtc gtg cgc atc cac ccg gag cct     1203
 Gln Gly Tyr Arg Trp Cys Leu His Val Val Arg Ile His Pro Glu Pro
 380                 385                 390                 395

 gtc atc cgc ttc cat aag gca gcc ttc ctg ggg cag cgt ggg ctg gta     1251
 Val Ile Arg Phe His Lys Ala Ala Phe Leu Gly Gln Arg Gly Leu Val
                 400                 405                 410

 gag gac gat ttc ctg atg aag gtg ctg gag ggc atg gcc ttt gct ggc     1299
 Glu Asp Asp Phe Leu Met Lys Val Leu Glu Gly Met Ala Phe Ala Gly
             415                 420                 425

 ttt gtg tca gag cgt ggg gtc cca tac cgc cct acg gac ctg ttc gat     1347
 Phe Val Ser Glu Arg Gly Val Pro Tyr Arg Pro Thr Asp Leu Phe Asp
         430                 435                 440

 gag ctg gtg gcc cac gag gtg gca agg atg cgg gcg gat gag aac cac     1395
 Glu Leu Val Ala His Glu Val Ala Arg Met Arg Ala Asp Glu Asn His
     445                 450                 455

 ccc cag cgt gtc ctg cgt cac gtc cag gaa ctg gca gag cag ctc tac     1443
 Pro Gln Arg Val Leu Arg His Val Gln Glu Leu Ala Glu Gln Leu Tyr
 460                 465                 470                 475

 aag aac gag aac ccg tac cca gcc gtg gcg atg cac aag gta cag agg     1491
 Lys Asn Glu Asn Pro Tyr Pro Ala Val Ala Met His Lys Val Gln Arg
                 480                 485                 490

 ccc ggt gag agc agc cac ctg cga cgg gtg ccc cga ccc ttc ccc cgg     1539
 Pro Gly Glu Ser Ser His Leu Arg Arg Val Pro Arg Pro Phe Pro Arg
             495                 500                 505

 ctg gat gag ggc acc gtg cag tgg atc gtg gac cag gct gca gcc aag     1587
 Leu Asp Glu Gly Thr Val Gln Trp Ile Val Asp Gln Ala Ala Ala Lys
         510                 515                 520

 atg cag ggt gca ccc cca gct gtg aag gcc gag agg agg acc acc gtg     1635
 Met Gln Gly Ala Pro Pro Ala Val Lys Ala Glu Arg Arg Thr Thr Val
     525                 530                 535

 ccc tca ggg ccc ccc atg act gcc ata ctg gag cgg tgc agt ggg ctg     1683
 Pro Ser Gly Pro Pro Met Thr Ala Ile Leu Glu Arg Cys Ser Gly Leu
 540                 545                 550                 555

 cat gtc aac agc gcc cgg cgg ctg gag gtt gtg cgc aac tgc atc tcc     1731
 His Val Asn Ser Ala Arg Arg Leu Glu Val Val Arg Asn Cys Ile Ser
                 560                 565                 570

 tac gtg ttt gag ggg aaa atg ctt gag gcc aag aag ctg ctc cca gcc     1779
 Tyr Val Phe Glu Gly Lys Met Leu Glu Ala Lys Lys Leu Leu Pro Ala
             575                 580                 585

 gtg ttg agg gcc ctg aag ggg cga gtt gcc cgc cgc tgc ctc gcc cag     1827
 Val Leu Arg Ala Leu Lys Gly Arg Val Ala Arg Arg Cys Leu Ala Gln
         590                 595                 600

 gag ctg cac ctg cat gtg cag cag aac cgt gcg gtc ctg gac cac cag     1875
 Glu Leu His Leu His Val Gln Gln Asn Arg Ala Val Leu Asp His Gln
     605                 610                 615

 cag ttt gac ttt gtc gtc cgt atg atg aac tgc tgc ctg cag gac tgc     1923
 Gln Phe Asp Phe Val Val Arg Met Met Asn Cys Cys Leu Gln Asp Cys
 620                 625                 630                 635

 act tct ctg gac gag cat ggc att gcg gcg gct ctg ctg cct ctg gtc     1971
 Thr Ser Leu Asp Glu His Gly Ile Ala Ala Ala Leu Leu Pro Leu Val
                 640                 645                 650

 aca gcc ttc tgc cgg aag ctg agc ccg ggg gtg acg cag ttt gca tac     2019
 Thr Ala Phe Cys Arg Lys Leu Ser Pro Gly Val Thr Gln Phe Ala Tyr
             655                 660                 665

 agc tgt gtg cag gag cac gtg gtg tgg agc acg cca cag ttc tgg gag     2067
 Ser Cys Val Gln Glu His Val Val Trp Ser Thr Pro Gln Phe Trp Glu
         670                 675                 680

 gcc atg ttc tat ggg gat gtg cag act cac atc cgg gcc ctc tac ctg     2115
 Ala Met Phe Tyr Gly Asp Val Gln Thr His Ile Arg Ala Leu Tyr Leu
     685                 690                 695

 gag ccc acg gag gac ctg gcc ccc gcc cag gag gtt ggg gag gca cct     2163
 Glu Pro Thr Glu Asp Leu Ala Pro Ala Gln Glu Val Gly Glu Ala Pro
 700                 705                 710                 715

 tcc cag gag gac gag cgc tct gcc cta gac gtg gct tct gag cag cgg     2211
 Ser Gln Glu Asp Glu Arg Ser Ala Leu Asp Val Ala Ser Glu Gln Arg
                 720                 725                 730

 cgc ttg tgg cca act ctg agt cgt gag aag cag cag gag ctg gtg cag     2259
 Arg Leu Trp Pro Thr Leu Ser Arg Glu Lys Gln Gln Glu Leu Val Gln
             735                 740                 745

 aag gag gag agc acg gtg ttc agc cag gcc atc cac tat gcc aac cgc     2307
 Lys Glu Glu Ser Thr Val Phe Ser Gln Ala Ile His Tyr Ala Asn Arg
         750                 755                 760

 atg agc tac ctc ctc ctg ccc ctg gac agc agc aag agc cgc cta ctt     2355
 Met Ser Tyr Leu Leu Leu Pro Leu Asp Ser Ser Lys Ser Arg Leu Leu
     765                 770                 775

 cgg gag cgt gcc ggg ctg ggc gac ctg gag agc gcc agc aac agc ctg     2403
 Arg Glu Arg Ala Gly Leu Gly Asp Leu Glu Ser Ala Ser Asn Ser Leu
 780                 785                 790                 795

 gtc acc aac agc atg gct ggc agt gtg gcc gag agc tat gac acg gag     2451
 Val Thr Asn Ser Met Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu
                 800                 805                 810

 agc ggc ttc gag gat gca gag acc tgc gac gta gct ggg gct gtg gtc     2499
 Ser Gly Phe Glu Asp Ala Glu Thr Cys Asp Val Ala Gly Ala Val Val
             815                 820                 825

 cgc ttc atc aac cgc ttt gtg gac aag gtc tgc acg gag agt ggg gtc     2547
 Arg Phe Ile Asn Arg Phe Val Asp Lys Val Cys Thr Glu Ser Gly Val
         830                 835                 840

 acc agc gac cac ctc aag ggg ctg cat gtc atg gtg cca gac att gtc     2595
 Thr Ser Asp His Leu Lys Gly Leu His Val Met Val Pro Asp Ile Val
     845                 850                 855

 cag atg cac atc gag acc ctg gag gcc gtg cag cgg gag agc cgg agg     2643
 Gln Met His Ile Glu Thr Leu Glu Ala Val Gln Arg Glu Ser Arg Arg
 860                 865                 870                 875

 ctg ccg ccc atc cag aag ccc aag ctg ctg cgg ccg cgc ctg ctg ccg     2691
 Leu Pro Pro Ile Gln Lys Pro Lys Leu Leu Arg Pro Arg Leu Leu Pro
                 880                 885                 890

 ggt gag gag tgt gtg ctg gac ggc ctg cgc gtc tac ctg ctg ccg gat     2739
 Gly Glu Glu Cys Val Leu Asp Gly Leu Arg Val Tyr Leu Leu Pro Asp
             895                 900                 905

 ggg cgt gag gag ggc gcg ggg ggc agt gct ggg gga cca gca ttg ctc     2787
 Gly Arg Glu Glu Gly Ala Gly Gly Ser Ala Gly Gly Pro Ala Leu Leu
         910                 915                 920

 cca gct gag ggc gcc gtc ttc ctc acc acg tac cgg gtc atc ttc acg     2835
 Pro Ala Glu Gly Ala Val Phe Leu Thr Thr Tyr Arg Val Ile Phe Thr
     925                 930                 935

 ggg atg ccc acg gac ccc ctg gtt ggg gag cag gtg gtg gtc cgc tcc     2883
 Gly Met Pro Thr Asp Pro Leu Val Gly Glu Gln Val Val Val Arg Ser
 940                 945                 950                 955

 ttc ccg gtg gct gcg ctg acc aag gag aag cgc atc agc gtc cag acc     2931
 Phe Pro Val Ala Ala Leu Thr Lys Glu Lys Arg Ile Ser Val Gln Thr
                 960                 965                 970

 cct gtg gac cag ctc ctg cag gac ggg ctc cag ctg cgc tcc tgc aca     2979
 Pro Val Asp Gln Leu Leu Gln Asp Gly Leu Gln Leu Arg Ser Cys Thr
             975                 980                 985

 ttc cag ctg ctg aaa atg gcc ttt gac gag gag gtg ggg tct gac agc     3027
 Phe Gln Leu Leu Lys Met Ala Phe Asp Glu Glu Val Gly Ser Asp Ser
         990                 995                1000

 gcc gag ctc ttc cgt aag cag ctg cat aag ctg cgg tac ccg ccg gac     3075
 Ala Glu Leu Phe Arg Lys Gln Leu His Lys Leu Arg Tyr Pro Pro Asp
    1005                1010                1015

 atc agg gcc acc ttt gcg ttc acc ttg ggc tct gcc cac aca cct ggc     3123
 Ile Arg Ala Thr Phe Ala Phe Thr Leu Gly Ser Ala His Thr Pro Gly
1020                1025                1030                1035

 cgg cca ccg cga gtc acc aag gac aag ggt cct tcc ctc aga acc ctg     3171
 Arg Pro Pro Arg Val Thr Lys Asp Lys Gly Pro Ser Leu Arg Thr Leu
                1040                1045                1050

 tcc cgg aac ctg gtc aag aac gcc aag aag acc atc ggg cgg cag cat     3219
 Ser Arg Asn Leu Val Lys Asn Ala Lys Lys Thr Ile Gly Arg Gln His
            1055                1060                1065

 gtc act cgc aag aag tac aac ccc ccc agc tgg gag cac cgg ggc cag     3267
 Val Thr Arg Lys Lys Tyr Asn Pro Pro Ser Trp Glu His Arg Gly Gln
        1070                1075                1080

 ccg ccc cct gag gac cag gag gac gag atc tca gtg tcg gag gag ctg     3315
 Pro Pro Pro Glu Asp Gln Glu Asp Glu Ile Ser Val Ser Glu Glu Leu
    1085                1090                1095

 gag ccc agc acg ctg acc ccg tcc tca gcc ctg aag ccc tcc gac cgc     3363
 Glu Pro Ser Thr Leu Thr Pro Ser Ser Ala Leu Lys Pro Ser Asp Arg
1100                1105                1110                1115

 atg acc atg agc agc ctg gtg gaa agg gct tgc tgt cgc gac tac cag     3411
 Met Thr Met Ser Ser Leu Val Glu Arg Ala Cys Cys Arg Asp Tyr Gln
                1120                1125                1130

 cgc ctc ggt ctg ggc acc ctg agc agc agc ctg agc cgg gcc aag tct     3459
 Arg Leu Gly Leu Gly Thr Leu Ser Ser Ser Leu Ser Arg Ala Lys Ser
            1135                1140                1145

 gag ccc ttc cgc att tct ccg gtc aac cgc atg tat gcc atc tgc cgc     3507
 Glu Pro Phe Arg Ile Ser Pro Val Asn Arg Met Tyr Ala Ile Cys Arg
        1150                1155                1160

 agc tac cca ggg ctg ctg atc gtg cgc cag agt gtc cag gac aac gcc     3555
 Ser Tyr Pro Gly Leu Leu Ile Val Arg Gln Ser Val Gln Asp Asn Ala
    1165                1170                1175

 ctg cag cgc gtg tcc cgc tgc tac cgc cag aac cgc ttc ccc gtg gtc     3603
 Leu Gln Arg Val Ser Arg Cys Tyr Arg Gln Asn Arg Phe Pro Val Val
1180                1185                1190                1195

 tgc tgg cgc agc ggg cgg tcc aag gcg gtg ctg ctg cgc tct gga ggc     3651
 Cys Trp Arg Ser Gly Arg Ser Lys Ala Val Leu Leu Arg Ser Gly Gly
                1200                1205                1210

 ctg cat ggc aaa ggt gtc gtc ggc ctc ttc aag gcc cag aac gca cct     3699
 Leu His Gly Lys Gly Val Val Gly Leu Phe Lys Ala Gln Asn Ala Pro
            1215                1220                1225

 tct cca ggc cag tcc cag gcg gac tcg agt agc ctg gag cag gag aag     3747
 Ser Pro Gly Gln Ser Gln Ala Asp Ser Ser Ser Leu Glu Gln Glu Lys
        1230                1235                1240

 tac ctg cag gct gtg gtc agc tcc atg ccc cgc tac gcc gac gcg tcg     3795
 Tyr Leu Gln Ala Val Val Ser Ser Met Pro Arg Tyr Ala Asp Ala Ser
    1245                1250                1255

 gga cgc aac acg ctt agc ggc ttc tcc tca gcc cac atg ggc agt cac     3843
 Gly Arg Asn Thr Leu Ser Gly Phe Ser Ser Ala His Met Gly Ser His
1260                1265                1270                1275

 ggt aag tgg ggc agt gtc cgg acc agt gga cgc agc agt ggc ctt ggc     3891
 Gly Lys Trp Gly Ser Val Arg Thr Ser Gly Arg Ser Ser Gly Leu Gly
                1280                1285                1290

 acc gat gtg ggc tcc cgg cta gct ggc aga gac gcg ctg gcc cca ccc     3939
 Thr Asp Val Gly Ser Arg Leu Ala Gly Arg Asp Ala Leu Ala Pro Pro
            1295                1300                1305

 cag gcc aac ggg ggc cct ccc gac ccg ggc ttc ctg cgt ccg cag cga     3987
 Gln Ala Asn Gly Gly Pro Pro Asp Pro Gly Phe Leu Arg Pro Gln Arg
        1310                1315                1320

 gca gcc ctc tat atc ctt ggg gac aaa gcc cag ctc aag ggt gtg cgg     4035
 Ala Ala Leu Tyr Ile Leu Gly Asp Lys Ala Gln Leu Lys Gly Val Arg
    1325                1330                1335

 tca gac ccc ctg cag cag tgg gag ctg gtg ccc att gag gta ttc gag     4083
 Ser Asp Pro Leu Gln Gln Trp Glu Leu Val Pro Ile Glu Val Phe Glu
1340                1345                1350                1355

 gca cgg cag gtg aag gct agc ttc aag aag ctg ctg aaa gca tgt gtc     4131
 Ala Arg Gln Val Lys Ala Ser Phe Lys Lys Leu Leu Lys Ala Cys Val
                1360                1365                1370

 cca ggc tgc ccc gct gct gag ccc agc cca gcc tcc ttc ctg cgc tca     4179
 Pro Gly Cys Pro Ala Ala Glu Pro Ser Pro Ala Ser Phe Leu Arg Ser
            1375                1380                1385

 ctg gag gac tca gag tgg ctg atc cag atc cac aag ctg ctg cag gtg     4227
 Leu Glu Asp Ser Glu Trp Leu Ile Gln Ile His Lys Leu Leu Gln Val
        1390                1395                1400

 tct gtg ctg gtg gtg gag ctc ctg gat tca ggc tcc tcc gtg ctg gtg     4275
 Ser Val Leu Val Val Glu Leu Leu Asp Ser Gly Ser Ser Val Leu Val
    1405                1410                1415

 ggc ctg gag gat ggc tgg gac atc acc acc cag gtg gta tcc ttg gtg     4323
 Gly Leu Glu Asp Gly Trp Asp Ile Thr Thr Gln Val Val Ser Leu Val
1420                1425                1430                1435

 cag ctg ctc tca gac ccc ttc tac cgc acg ctg gag ggc ttt cgc ctg     4371
 Gln Leu Leu Ser Asp Pro Phe Tyr Arg Thr Leu Glu Gly Phe Arg Leu
                1440                1445                1450

 ctg gtg gag aag gag tgg ctg tcc ttc ggc cat cgc ttc agc cac cgt     4419
 Leu Val Glu Lys Glu Trp Leu Ser Phe Gly His Arg Phe Ser His Arg
            1455                1460                1465

 gga gct cac acc ctg gcc ggg cag agc agc ggc ttc aca ccc gtc ttc     4467
 Gly Ala His Thr Leu Ala Gly Gln Ser Ser Gly Phe Thr Pro Val Phe
        1470                1475                1480

 ctg cag ttc ctg gac tgc gta cac cag gtc cac ctg cag ttc ccc atg     4515
 Leu Gln Phe Leu Asp Cys Val His Gln Val His Leu Gln Phe Pro Met
    1485                1490                1495

 gag ttt gag ttc agc cag ttc tac ctc aag ttc ctc ggc tac cac cat     4563
 Glu Phe Glu Phe Ser Gln Phe Tyr Leu Lys Phe Leu Gly Tyr His His
1500                1505                1510                1515

 gtg tcc cgc cgt ttc cgg acc ttc ctg ctc gac tct gac tat gag cgc     4611
 Val Ser Arg Arg Phe Arg Thr Phe Leu Leu Asp Ser Asp Tyr Glu Arg
                1520                1525                1530

 att gag ctg ggg ctg ctg tat gag gag aag ggg gaa cgc agg ggc cag     4659
 Ile Glu Leu Gly Leu Leu Tyr Glu Glu Lys Gly Glu Arg Arg Gly Gln
            1535                1540                1545

 gtg ccg tgc agg tct gtg tgg gag tat gtg gac cgg ctg agc aag agg     4707
 Val Pro Cys Arg Ser Val Trp Glu Tyr Val Asp Arg Leu Ser Lys Arg
        1550                1555                1560

 acg cct gtg ttc cac aat tac atg tat gcg ccc gag gac gca gag gtc     4755
 Thr Pro Val Phe His Asn Tyr Met Tyr Ala Pro Glu Asp Ala Glu Val
    1565                1570                1575

 ctg cgg ccc tac agc aac gtg tcc aac ctg aag gtg tgg gac ttc tac     4803
 Leu Arg Pro Tyr Ser Asn Val Ser Asn Leu Lys Val Trp Asp Phe Tyr
1580                1585                1590                1595

 act gag gag acg ctg gcc gag ggc cct ccc tat gac tgg gaa ctg gcc     4851
 Thr Glu Glu Thr Leu Ala Glu Gly Pro Pro Tyr Asp Trp Glu Leu Ala
                1600                1605                1610

 cag ggg ccc cct gaa ccc cca gag gaa gaa cgg tct gat gga ggc gct     4899
 Gln Gly Pro Pro Glu Pro Pro Glu Glu Glu Arg Ser Asp Gly Gly Ala
            1615                1620                1625

 ccc cag agc agg cgc cgc gtg gtg tgg ccc tgt tac gac agc tgc ccg     4947
 Pro Gln Ser Arg Arg Arg Val Val Trp Pro Cys Tyr Asp Ser Cys Pro
        1630                1635                1640

 cgg gcc cag cct gac gcc atc tca cgc ctg ctg gag gag ctg cag agg     4995
 Arg Ala Gln Pro Asp Ala Ile Ser Arg Leu Leu Glu Glu Leu Gln Arg
    1645                1650                1655

 ctg gag aca gag ttg ggc caa ccc gct gag cgc tgg aag gac acc tgg     5043
 Leu Glu Thr Glu Leu Gly Gln Pro Ala Glu Arg Trp Lys Asp Thr Trp
1660                1665                1670                1675

 gac cgg gtg aag gct gca cag cgc ctc gag ggc cgg cca gac ggc cgt     5091
 Asp Arg Val Lys Ala Ala Gln Arg Leu Glu Gly Arg Pro Asp Gly Arg
                1680                1685                1690

 ggc acc cct agc tcc ctc ctt gtg tcc acc gca ccc cac cac cgt cgc     5139
 Gly Thr Pro Ser Ser Leu Leu Val Ser Thr Ala Pro His His Arg Arg
            1695                1700                1705

 tcg ctg ggt gtg tac ctg cag gag ggg ccc gtg ggc tcc acc ctg agc     5187
 Ser Leu Gly Val Tyr Leu Gln Glu Gly Pro Val Gly Ser Thr Leu Ser
        1710                1715                1720

 ctc agc ctg gac agc gac cag agt agt ggc tca acc aca tcc ggc tcc     5235
 Leu Ser Leu Asp Ser Asp Gln Ser Ser Gly Ser Thr Thr Ser Gly Ser
    1725                1730                1735

 cgt cag gct gcc cgc cgc agc acc agc acc ctg tac agc cag ttc cag     5283
 Arg Gln Ala Ala Arg Arg Ser Thr Ser Thr Leu Tyr Ser Gln Phe Gln
1740                1745                1750                1755

 aca gca gag agt gag aac agg tcc tac gag ggc act ctg tac aag aag     5331
 Thr Ala Glu Ser Glu Asn Arg Ser Tyr Glu Gly Thr Leu Tyr Lys Lys
                1760                1765                1770

 ggg gcc ttc atg aag cct tgg aag gcc cgc tgg ttc gtg ctg gac aag     5379
 Gly Ala Phe Met Lys Pro Trp Lys Ala Arg Trp Phe Val Leu Asp Lys
            1775                1780                1785

 acc aag cac cag ctg cgc tac tac gac cac cgt gtg gac aca gag tgc     5427
 Thr Lys His Gln Leu Arg Tyr Tyr Asp His Arg Val Asp Thr Glu Cys
        1790                1795                1800

 aag ggt gtc atc gac ttg gcg gag gtg gag gct gtg gca cct ggc acg     5475
 Lys Gly Val Ile Asp Leu Ala Glu Val Glu Ala Val Ala Pro Gly Thr
    1805                1810                1815

 ccc act atg ggt gcc cct aag act gtg gac gag aag gcc ttc ttt gac     5523
 Pro Thr Met Gly Ala Pro Lys Thr Val Asp Glu Lys Ala Phe Phe Asp
1820                1825                1830                1835

 gtg aag aca acg cgt cgc gtt tac aac ttc tgt gcc cag gac gtg ccc     5571
 Val Lys Thr Thr Arg Arg Val Tyr Asn Phe Cys Ala Gln Asp Val Pro
                1840                1845                1850

 tcg gcc cag cag tgg gtg gac cgg atc cag agc tgc ctg tcg gac gcc     5619
 Ser Ala Gln Gln Trp Val Asp Arg Ile Gln Ser Cys Leu Ser Asp Ala
            1855                1860                1865

 tga gcct cccagccctg cccggctgct ctgcttccgg tcgttaccga ccactagggg     5676
 






      <210> 87
      <211> 1769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (282)..(1769)

      <400> 87
 caggccgagt gtcccaaggg caaaatgctg agaacgtcca ctcctaatct gtgtggtggt     60

 ctgcattggc gggccccctg tgctctcttc tggcattctc tgcctctgtc ctcatattct    120

 tgttaggcca ggtgggcttg ctgcagggac acccccagtg cctggattac gggccccctt    180

 tccagccccc tctgcacctt gagttttgct ctgactatga gtccttcggc tgctgtgatc    240

 agcacaagga ccgccgcatc gctgcccggt actgggacat c    atg gaa tat ttt     293
                                                  Met Glu Tyr Phe
                                                    1

 gat ctg aag aga cat gag ctg tgt gga gat tac att aaa gac atc ctt      341
 Asp Leu Lys Arg His Glu Leu Cys Gly Asp Tyr Ile Lys Asp Ile Leu
   5                  10                  15                  20

 tgc cag gag tgc tcg ccc tac gca gcc cac ctc tac gac gcc gaa aac      389
 Cys Gln Glu Cys Ser Pro Tyr Ala Ala His Leu Tyr Asp Ala Glu Asn
                  25                  30                  35

 acc cag acg cct ctc cgg aat ctc ccg ggc ctc tgc tct gat tac tgc      437
 Thr Gln Thr Pro Leu Arg Asn Leu Pro Gly Leu Cys Ser Asp Tyr Cys
              40                  45                  50

 tct gcc ttc cat tct aac tgt cac tca gcc att tcc ctg ctg acc aat      485
 Ser Ala Phe His Ser Asn Cys His Ser Ala Ile Ser Leu Leu Thr Asn
          55                  60                  65

 gac cgc ggc ctc cag gag tct cat gga agg gac ggt acc cgc ttc tgc      533
 Asp Arg Gly Leu Gln Glu Ser His Gly Arg Asp Gly Thr Arg Phe Cys
      70                  75                  80

 cac ctc ctg gac ctt cct gac aag gac tat tgc ttc cct aat gtc ctg      581
 His Leu Leu Asp Leu Pro Asp Lys Asp Tyr Cys Phe Pro Asn Val Leu
  85                  90                  95                 100

 agg aac gac tat ctc aac cgc cac ctg ggc atg gtg gcc caa gat cct      629
 Arg Asn Asp Tyr Leu Asn Arg His Leu Gly Met Val Ala Gln Asp Pro
                 105                 110                 115

 cag ggc tgc ctg cag ctc tgc ctg agc gag gtg gcc aac ggg ctg agg      677
 Gln Gly Cys Leu Gln Leu Cys Leu Ser Glu Val Ala Asn Gly Leu Arg
             120                 125                 130

 aac ccc gtc tcc atg gtc cat gct ggg gac ggc acc cat cgc ttc ttt      725
 Asn Pro Val Ser Met Val His Ala Gly Asp Gly Thr His Arg Phe Phe
         135                 140                 145

 gtt gcc gag cag gta gga gtg gtg tgg gtc tac ctc cct gat ggg agt      773
 Val Ala Glu Gln Val Gly Val Val Trp Val Tyr Leu Pro Asp Gly Ser
     150                 155                 160

 cgc ctg gag caa ccc ttc ctg gac ctc aag aac atc gtg ttg acc acc      821
 Arg Leu Glu Gln Pro Phe Leu Asp Leu Lys Asn Ile Val Leu Thr Thr
 165                 170                 175                 180

 cca tgg atc ggg gat gag aga ggc ttc ttg ggg ttg gct ttt cac ccc      869
 Pro Trp Ile Gly Asp Glu Arg Gly Phe Leu Gly Leu Ala Phe His Pro
                 185                 190                 195

 aaa ttc cgc cac aat cgc aag ttc tat att tat tat tcg tgc ctg gac      917
 Lys Phe Arg His Asn Arg Lys Phe Tyr Ile Tyr Tyr Ser Cys Leu Asp
             200                 205                 210

 aag aag aag gta gaa aag atc cga att agt gag atg aag gtt tct cgg      965
 Lys Lys Lys Val Glu Lys Ile Arg Ile Ser Glu Met Lys Val Ser Arg
         215                 220                 225

 gct gat cct aac aaa gct gac ctg aaa tca gag agg gtc atc ttg gag     1013
 Ala Asp Pro Asn Lys Ala Asp Leu Lys Ser Glu Arg Val Ile Leu Glu
     230                 235                 240

 att gaa gaa cca gcc tca aac cat aat ggc gga caa ctt ctt ttt ggc     1061
 Ile Glu Glu Pro Ala Ser Asn His Asn Gly Gly Gln Leu Leu Phe Gly
 245                 250                 255                 260

 ctg gat ggc tat atg tac ata ttc act ggg gac ggg gga cag gct gga     1109
 Leu Asp Gly Tyr Met Tyr Ile Phe Thr Gly Asp Gly Gly Gln Ala Gly
                 265                 270                 275

 gat ccc ttt ggc ctg ttt gga aat gct cag aac aaa agt tcc ctg ctg     1157
 Asp Pro Phe Gly Leu Phe Gly Asn Ala Gln Asn Lys Ser Ser Leu Leu
             280                 285                 290

 gga aaa gtt tta agg atc gat gtg aac agg gca ggc tca cat ggc aag     1205
 Gly Lys Val Leu Arg Ile Asp Val Asn Arg Ala Gly Ser His Gly Lys
         295                 300                 305

 cgg tac cga gtc ccc tcg gac aat cca ttt gtt tct gag cca ggg gcc     1253
 Arg Tyr Arg Val Pro Ser Asp Asn Pro Phe Val Ser Glu Pro Gly Ala
     310                 315                 320

 cac ccc gcc atc tat gcc tat ggg atc agg aac atg tgg cgt tgt gct     1301
 His Pro Ala Ile Tyr Ala Tyr Gly Ile Arg Asn Met Trp Arg Cys Ala
 325                 330                 335                 340

 gtg gac cga ggg gac ccc atc acg cgc cag ggc cga ggc cgg ata ttc     1349
 Val Asp Arg Gly Asp Pro Ile Thr Arg Gln Gly Arg Gly Arg Ile Phe
                 345                 350                 355

 tgt ggg gac gtg ggc cag aac agg ttt gaa gag gtt gac ctc att ttg     1397
 Cys Gly Asp Val Gly Gln Asn Arg Phe Glu Glu Val Asp Leu Ile Leu
             360                 365                 370

 aaa ggt gga aac tat ggc tgg aga gca aag gaa ggg ttt gca tgt tat     1445
 Lys Gly Gly Asn Tyr Gly Trp Arg Ala Lys Glu Gly Phe Ala Cys Tyr
         375                 380                 385

 gac aaa aaa ctt tgt cac aat gcc tct ttg gag gag caa gcc aca gaa     1493
 Asp Lys Lys Leu Cys His Asn Ala Ser Leu Glu Glu Gln Ala Thr Glu
     390                 395                 400

 gat ggc agc cca gaa tcc ctg ggc agg cct gcc tct ggg gtt cca atc     1541
 Asp Gly Ser Pro Glu Ser Leu Gly Arg Pro Ala Ser Gly Val Pro Ile
 405                 410                 415                 420

 tct ggg gtg gtg ctg gac aca ggg gtg tcc ggc aga gga gag gct cca     1589
 Ser Gly Val Val Leu Asp Thr Gly Val Ser Gly Arg Gly Glu Ala Pro
                 425                 430                 435

 cca ccg cct gca gct ttc acc aaa gga gat gat gaa ctt gct atg ggt     1637
 Pro Pro Pro Ala Ala Phe Thr Lys Gly Asp Asp Glu Leu Ala Met Gly
             440                 445                 450

 gct gat cag ccc tgg gaa ggc aca gga cgt ggt gct gcc cag gca aag     1685
 Ala Asp Gln Pro Trp Glu Gly Thr Gly Arg Gly Ala Ala Gln Ala Lys
         455                 460                 465

 atc ctg ctt ctt cca ttt ctt gtt ttt tct atc ttc ctg caa agc cat     1733
 Ile Leu Leu Leu Pro Phe Leu Val Phe Ser Ile Phe Leu Gln Ser His
     470                 475                 480

 aag tcg act aga caa aaa ata aac cct tat gtt tag                     1769
 Lys Ser Thr Arg Gln Lys Ile Asn Pro Tyr Val 
 485                 490                 495





      <210> 88
      <211> 792
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (92)..(745)

      <400> 88
 tttcgtccat cgttactttg gtgaaagcat gaataaatat acatctactg tatgatcacc     60

 cagtctactt gaaaaggatc ctgcctttca g   atg att act att gcc aag gaa     112
                                      Met Ile Thr Ile Ala Lys Glu
                                        1               5

 aca ggc ctt ggc ctg aag gta cta gga gga att aac cgg aat gaa ggc      160
 Thr Gly Leu Gly Leu Lys Val Leu Gly Gly Ile Asn Arg Asn Glu Gly
          10                  15                  20

 cca ttg gta tat att cag gaa att att cct gga gga gac tgt tat aag      208
 Pro Leu Val Tyr Ile Gln Glu Ile Ile Pro Gly Gly Asp Cys Tyr Lys
      25                  30                  35

 gat ggt cgt ttg aag cca gga gat caa ctt gtc tca gtc aac aag gaa      256
 Asp Gly Arg Leu Lys Pro Gly Asp Gln Leu Val Ser Val Asn Lys Glu
  40                  45                  50                  55

 tct atg att ggt gta tca ttt gaa gaa gca aaa agc ata att acc aga      304
 Ser Met Ile Gly Val Ser Phe Glu Glu Ala Lys Ser Ile Ile Thr Arg
                  60                  65                  70

 gcc aag ttg agg tta gaa tct gct tgg gag ata gca ttc ata aga caa      352
 Ala Lys Leu Arg Leu Glu Ser Ala Trp Glu Ile Ala Phe Ile Arg Gln
              75                  80                  85

 aaa tcc gac aac att cag cca gaa aat ctg tca tgt aca tca ctt ata      400
 Lys Ser Asp Asn Ile Gln Pro Glu Asn Leu Ser Cys Thr Ser Leu Ile
          90                  95                 100

 gaa gct tca gga gaa tat gga cct caa gcc tca aca tta agt ctt ttt      448
 Glu Ala Ser Gly Glu Tyr Gly Pro Gln Ala Ser Thr Leu Ser Leu Phe
     105                 110                 115

 tct tct cct cct gaa ata cta atc cca aag acc tca tcc act ccc aaa      496
 Ser Ser Pro Pro Glu Ile Leu Ile Pro Lys Thr Ser Ser Thr Pro Lys
 120                 125                 130                 135

 aca aat aat gac att tta tct tct tgt gag ata aaa act gga tac aac      544
 Thr Asn Asn Asp Ile Leu Ser Ser Cys Glu Ile Lys Thr Gly Tyr Asn
                 140                 145                 150

 aaa aca gta cag att cca att act tca gaa aac agt act gtg ggt ttg      592
 Lys Thr Val Gln Ile Pro Ile Thr Ser Glu Asn Ser Thr Val Gly Leu
             155                 160                 165

 tct aat aca ggc tct aaa tta tct tgg tat tca gcc cac aaa gga aca      640
 Ser Asn Thr Gly Ser Lys Leu Ser Trp Tyr Ser Ala His Lys Gly Thr
         170                 175                 180

 aca cca agc cct gag aca gca agt aca agc aga ctc aaa agg gac agt      688
 Thr Pro Ser Pro Glu Thr Ala Ser Thr Ser Arg Leu Lys Arg Asp Ser
     185                 190                 195

 gtc ttt tgg aga ttt tgt cca ggt tgc cag aaa ctt gtt ttg ctt gca      736
 Val Phe Trp Arg Phe Cys Pro Gly Cys Gln Lys Leu Val Leu Leu Ala
 200                 205                 210                 215

 gtt gga tga agtaaat gttggtgcac atgaaatttc caatatatta gattcacagc      792
 Val Gly 






      <210> 89
      <211> 937
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(646)

      <400> 89
 attcaggcgg gttctcttcg gctccgcgca gcccgcgccg cggtggggga cccggcgcag     60

 cggcacctgc tgccgaggga ccccgcggcc cgccccggtg ctcgtg   atg ggg ctg     115
                                                      Met Gly Leu
                                                        1

 atc ttc gcc aaa ctg tgg agc ctc ttc tgt aac caa gaa cac aaa gta      163
 Ile Phe Ala Lys Leu Trp Ser Leu Phe Cys Asn Gln Glu His Lys Val
       5                  10                  15

 att ata gtg gga ctg gat aat gca ggg aaa acc acc att ctt tac caa      211
 Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile Leu Tyr Gln
  20                  25                  30                  35

 ttc tta atg aat gaa gtg gtt cac act tct cca acc ata gga agc aat      259
 Phe Leu Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn
                  40                  45                  50

 gtt gaa gaa ata gtt gtg aag aac act cat ttt ctt atg tgg gat att      307
 Val Glu Glu Ile Val Val Lys Asn Thr His Phe Leu Met Trp Asp Ile
              55                  60                  65

 ggt ggt cag gag tct ctg cga tca tcc tgg aac aca tat tac tca aat      355
 Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Ser Asn
          70                  75                  80

 aca gag ttc atc att ctt gtt gtt gat agc att gac agg gaa cga cta      403
 Thr Glu Phe Ile Ile Leu Val Val Asp Ser Ile Asp Arg Glu Arg Leu
      85                  90                  95

 gct att aca aaa gaa gaa tta tac aga atg ttg gct cat gag gat tta      451
 Ala Ile Thr Lys Glu Glu Leu Tyr Arg Met Leu Ala His Glu Asp Leu
 100                 105                 110                 115

 cgg aag gct gca gtc ctt atc ttt gca aat aaa cag gat atg aaa ggg      499
 Arg Lys Ala Ala Val Leu Ile Phe Ala Asn Lys Gln Asp Met Lys Gly
                 120                 125                 130

 tgt atg aca gca gct gaa atc tcg aaa tac ctc acc ctt agt tca att      547
 Cys Met Thr Ala Ala Glu Ile Ser Lys Tyr Leu Thr Leu Ser Ser Ile
             135                 140                 145

 aag gat cat cca tgg cac att caa tcc tgc tgt gct ctc aca gga gaa      595
 Lys Asp His Pro Trp His Ile Gln Ser Cys Cys Ala Leu Thr Gly Glu
         150                 155                 160

 ggg tta tgc caa ggt cta gag tgg atg acc tcc cgg att ggt gtg aga      643
 Gly Leu Cys Gln Gly Leu Glu Trp Met Thr Ser Arg Ile Gly Val Arg
     165                 170                 175

 taa cttt tttgcttgaa agagactgct ctatttattc tgtgacatga acattttttc      700
 


 ctagtacctt tggctgctaa ggcagcagca tgtttaattt ataacaacac aaacctctga    760

 gagcaacact tgaatcaagt gcagctgaac tggaacataa aagatttttt cttaactttt    820

 tttttttaac acactaatct tcagttggat gaatgtaatg tataactatg ttttcagcaa    880

 caattcttct gtttattcta attaatcagt gactgccttg taagaaaaaa aaaaaaa       937




      <210> 90
      <211> 4397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (306)..(4397)

      <400> 90
 ccctggacct gtcccgcttg gtcacacgat gggaccctcg gcccatcagc agcgccttca     60

 actgtgaaga ggtgaactct tcaaacacgc tgagcaaaca ggcccgactc ccagggccgc    120

 atccgggatg tctcaatagc tgtggccttg acgtccacct cggacccctg ccccggaccc    180

 agcccagttc ccaatgggcc ctctgcccgg ggagcgggtc taccggcctg gatgtgaaag    240

 agagcttgga gaccccagag acctcggaac cttcagcttt ggaagtgacg tcggtggggg    300

 tcccc    atg ggg ccg gac gag gcc aca cca ccc gac ctg gtg ctt cct     347
          Met Gly Pro Asp Glu Ala Thr Pro Pro Asp Leu Val Leu Pro
            1               5                  10

 gcc tgg cgt ctg cgc cac gga gca ttc agg acg ctg gtg acc agg gag      395
 Ala Trp Arg Leu Arg His Gly Ala Phe Arg Thr Leu Val Thr Arg Glu
  15                  20                  25                  30

 cca gga gcc ccc agg atg ggt gcc ccg agc gcg tgc cgg acg ctg gtg      443
 Pro Gly Ala Pro Arg Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val
                  35                  40                  45

 ttg gct ctg gcg gcc atg ctc gtg gtg ccg cag gca gag acc cag ggc      491
 Leu Ala Leu Ala Ala Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly
              50                  55                  60

 cct gtg gag ccg agc tgg gag aat gca ggg cac acc atg gat ggc ggt      539
 Pro Val Glu Pro Ser Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly
          65                  70                  75

 gcc ccg acg tcc tcg ccc acc cgg cgc gtg agc ttt gtt cca ccc gtc      587
 Ala Pro Thr Ser Ser Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val
      80                  85                  90

 act gtc ttc ccc agc ctg agc ccc ctg aac ccg gcg cac aat ggg cgg      635
 Thr Val Phe Pro Ser Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg
  95                 100                 105                 110

 gtg tgc agc acc tgg ggt gac ttc cac tac aag acc ttc gac ggc gac      683
 Val Cys Ser Thr Trp Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp
                 115                 120                 125

 gtc ttc cgc ttc cct ggc ctt tgc aac tac gtg ttc tct gag cac tgc      731
 Val Phe Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys
             130                 135                 140

 cgc gcc gcc tac gag gac ttc aac gtc cag cta cgc cga ggc cta gtg      779
 Arg Ala Ala Tyr Glu Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val
         145                 150                 155

 ggc tcc agg cct gtg gtc acc cgt gtt gtc atc aag gcc cag ggg ctg      827
 Gly Ser Arg Pro Val Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu
     160                 165                 170

 gtg ctg gag gcg tcc aac ggc tcc gtc ctc atc aat ggg cag cgg gag      875
 Val Leu Glu Ala Ser Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu
 175                 180                 185                 190

 gag ctg cct tac agc cgc act ggc ctc ctg gtg gag cag agc ggg gac      923
 Glu Leu Pro Tyr Ser Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp
                 195                 200                 205

 tac atc aag gtc agc atc cgg ctg gtg ctg aca ttc ctg tgg aac gga      971
 Tyr Ile Lys Val Ser Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly
             210                 215                 220

 gag gac agt gcc ctg ctg gag ctg gat ccc aaa tac gcc aac cag acc     1019
 Glu Asp Ser Ala Leu Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr
         225                 230                 235

 tgt ggc ctg tgt ggg gac ttc aac ggc ctc ccg gcc ttc aac gag ttc     1067
 Cys Gly Leu Cys Gly Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe
     240                 245                 250

 tat gcc cac agt gag tgc cac ctg gac gcc agg ctg acc ccg ctc cag     1115
 Tyr Ala His Ser Glu Cys His Leu Asp Ala Arg Leu Thr Pro Leu Gln
 255                 260                 265                 270

 ttt ggg aac ctg cag aag ttg gat ggg ccc acg gag cag tgc ccg gac     1163
 Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro Thr Glu Gln Cys Pro Asp
                 275                 280                 285

 ccg ctg ccc ttg ccg gcc ggc aac tgc acg gac gag gag ggc atc tgc     1211
 Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr Asp Glu Glu Gly Ile Cys
             290                 295                 300

 cac cgc acc ctg ctg ggg ccg gcc ttt gcg gag tgc cac gca ctg gtg     1259
 His Arg Thr Leu Leu Gly Pro Ala Phe Ala Glu Cys His Ala Leu Val
         305                 310                 315

 gac agc act gcg tac ctg gcc gcc tgc gcc cag gac ctg tgc cgc tgc     1307
 Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala Gln Asp Leu Cys Arg Cys
     320                 325                 330

 ccc acc tgc ccg tgt gcc acc ttt gtg gaa tac tca cgc cag tgc gcc     1355
 Pro Thr Cys Pro Cys Ala Thr Phe Val Glu Tyr Ser Arg Gln Cys Ala
 335                 340                 345                 350

 cac gcg ggg ggc cag ccg cgg aac tgg agg tgc cct gag ctc tgc ccc     1403
 His Ala Gly Gly Gln Pro Arg Asn Trp Arg Cys Pro Glu Leu Cys Pro
                 355                 360                 365

 cgg acc tgc ccc ctc aac atg cag cac cag gag tgt ggc tca ccc tgc     1451
 Arg Thr Cys Pro Leu Asn Met Gln His Gln Glu Cys Gly Ser Pro Cys
             370                 375                 380

 acg gac acc tgc tcc aac ccc cag cgc gcg cag ctc tgt gag gac cac     1499
 Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala Gln Leu Cys Glu Asp His
         385                 390                 395

 tgt gtg gac ggc tgc ttc tgc ccc cca ggc acg gtg ctg gat gac atc     1547
 Cys Val Asp Gly Cys Phe Cys Pro Pro Gly Thr Val Leu Asp Asp Ile
     400                 405                 410

 acg cac tct ggc tgc ctg ccc ctc ggg cag tgc ccc tgc acc cac ggc     1595
 Thr His Ser Gly Cys Leu Pro Leu Gly Gln Cys Pro Cys Thr His Gly
 415                 420                 425                 430

 ggc cgc acc tac agc ccg ggc acc tcc ttc aac acc acc tgc agc tcc     1643
 Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe Asn Thr Thr Cys Ser Ser
                 435                 440                 445

 tgc acc tgc tcc ggg ggg cta tgg cag tgc cag gac ctg ccg tgc cct     1691
 Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys Gln Asp Leu Pro Cys Pro
             450                 455                 460

 ggc acc tgc tct gtg cag ggc ggg gcc cac atc tcc acc tat gat gag     1739
 Gly Thr Cys Ser Val Gln Gly Gly Ala His Ile Ser Thr Tyr Asp Glu
         465                 470                 475

 aaa ctc tac gac ctg cat ggt gac tgc agc tac gtt ctg tcc aag aaa     1787
 Lys Leu Tyr Asp Leu His Gly Asp Cys Ser Tyr Val Leu Ser Lys Lys
     480                 485                 490

 tgt gcc gac agc agc ttc acc gtg ctg gct gag ctg cgg aag tgc ggc     1835
 Cys Ala Asp Ser Ser Phe Thr Val Leu Ala Glu Leu Arg Lys Cys Gly
 495                 500                 505                 510

 ctg acg gac aac gag aac tgc ctg aaa gcg gtg acg ctc agc ctg gac     1883
 Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala Val Thr Leu Ser Leu Asp
                 515                 520                 525

 ggc ggg gac acg gcc atc cgg gtc caa gcg gac ggc ggc gtg ttc ctc     1931
 Gly Gly Asp Thr Ala Ile Arg Val Gln Ala Asp Gly Gly Val Phe Leu
             530                 535                 540

 aac tcc atc tac acg cag ctg ccc ctg tcg gca gcc aac atc acc ctg     1979
 Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser Ala Ala Asn Ile Thr Leu
         545                 550                 555

 ttc aca ccc tcg agc ttc ttc atc gtg gtg cag aca ggc ctg ggg ctg     2027
 Phe Thr Pro Ser Ser Phe Phe Ile Val Val Gln Thr Gly Leu Gly Leu
     560                 565                 570

 cag ctg ctg gtg cag ctg gtg cca ctc atg cag gtg ttt gtc agg ctg     2075
 Gln Leu Leu Val Gln Leu Val Pro Leu Met Gln Val Phe Val Arg Leu
 575                 580                 585                 590

 gac ccc gcc cac cag ggc cag atg tgc ggc ctg tgt ggg aac ttc aac     2123
 Asp Pro Ala His Gln Gly Gln Met Cys Gly Leu Cys Gly Asn Phe Asn
                 595                 600                 605

 cag aac cag gct gac gac ttc acg gcc ctc agc ggg gtg gtg gag gcc     2171
 Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu Ser Gly Val Val Glu Ala
             610                 615                 620

 acg ggc gca gcc ttc gcc aac acc tgg aag gcc cag gct gcc tgt gcc     2219
 Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys Ala Gln Ala Ala Cys Ala
         625                 630                 635

 aat gcc agg aac agc ttt gag gac ccc tgc tcc ctc agt gtg gag aat     2267
 Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn
     640                 645                 650

 gag aac tac gcc cgg cac tgg tgc tcg cgc ctg acc gat ccc aac agt     2315
 Glu Asn Tyr Ala Arg His Trp Cys Ser Arg Leu Thr Asp Pro Asn Ser
 655                 660                 665                 670

 gcc ttc tcg cgc tgc cac tcc atc atc aac ccc aag ccc ttc cac tcg     2363
 Ala Phe Ser Arg Cys His Ser Ile Ile Asn Pro Lys Pro Phe His Ser
                 675                 680                 685

 aac tgc atg ttc gac acc tgc aac tgt gag cgg agc gag gac tgc ctg     2411
 Asn Cys Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu
             690                 695                 700

 tgc gcc gcg ctg tcc tcc tat gtg cac gcc tgt gcc gcc aag ggc gta     2459
 Cys Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val
         705                 710                 715

 cag ctc agc gac tgg agg gac ggc gtc tgc acc aag tac atg cag aac     2507
 Gln Leu Ser Asp Trp Arg Asp Gly Val Cys Thr Lys Tyr Met Gln Asn
     720                 725                 730

 tgc ccc aag tcc cag cgc tac gcc tac gtg gtg gat gcc tgc cag ccc     2555
 Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val Val Asp Ala Cys Gln Pro
 735                 740                 745                 750

 act tgc cgc ggc ctg agt gag gcc gac gtc acc tgc agc gtt tcc ttc     2603
 Thr Cys Arg Gly Leu Ser Glu Ala Asp Val Thr Cys Ser Val Ser Phe
                 755                 760                 765

 gtg cct gtg gac ggc tgc acc tgc ccc gcg ggc acc ttc ctc aat gac     2651
 Val Pro Val Asp Gly Cys Thr Cys Pro Ala Gly Thr Phe Leu Asn Asp
             770                 775                 780

 gcg ggc gcc tgt gtg ccc gcc cag aag tgc ccc tgc tac gct cac ggc     2699
 Ala Gly Ala Cys Val Pro Ala Gln Lys Cys Pro Cys Tyr Ala His Gly
         785                 790                 795

 acc gtg ctg gct cct gga gag gtg gtg cac gac gag ggc gcc gtg tgt     2747
 Thr Val Leu Ala Pro Gly Glu Val Val His Asp Glu Gly Ala Val Cys
     800                 805                 810

 tca tgt acg ggt ggg aag cta agc tgc ctg gga gcc tct ctg cag aaa     2795
 Ser Cys Thr Gly Gly Lys Leu Ser Cys Leu Gly Ala Ser Leu Gln Lys
 815                 820                 825                 830

 agc aca ggg tgt gca gcc ccc atg gtg tac ctg gac tgc agc aac agc     2843
 Ser Thr Gly Cys Ala Ala Pro Met Val Tyr Leu Asp Cys Ser Asn Ser
                 835                 840                 845

 tcg gcg ggc acc cct ggg gcc gag tgc ctc cgg agc tgc cac acg ctg     2891
 Ser Ala Gly Thr Pro Gly Ala Glu Cys Leu Arg Ser Cys His Thr Leu
             850                 855                 860

 gac gtg ggc tgt ttc agc aca cac tgc gtg tcc ggc tgt gtc tgt ccc     2939
 Asp Val Gly Cys Phe Ser Thr His Cys Val Ser Gly Cys Val Cys Pro
         865                 870                 875

 ccg ggg ctg gtg tcg gat ggg agt ggg ggc tgc att gcc gag gag gac     2987
 Pro Gly Leu Val Ser Asp Gly Ser Gly Gly Cys Ile Ala Glu Glu Asp
     880                 885                 890

 tgc ccc tgt gtg cac aac gag gcc acc tac aag cct gga gag acc atc     3035
 Cys Pro Cys Val His Asn Glu Ala Thr Tyr Lys Pro Gly Glu Thr Ile
 895                 900                 905                 910

 agg gtc gac tgc aac acc tgc acc tgc agg aac cgg agg tgg gag tgc     3083
 Arg Val Asp Cys Asn Thr Cys Thr Cys Arg Asn Arg Arg Trp Glu Cys
                 915                 920                 925

 agc cac cgg ctc tgc ctg ggc acc tgc gtg gcc tac ggg gat ggc cac     3131
 Ser His Arg Leu Cys Leu Gly Thr Cys Val Ala Tyr Gly Asp Gly His
             930                 935                 940

 ttc atc acc ttt gat ggc gat cgc tac agc ttt gaa ggc agc tgc gag     3179
 Phe Ile Thr Phe Asp Gly Asp Arg Tyr Ser Phe Glu Gly Ser Cys Glu
         945                 950                 955

 tac atc ttg gcc cag gac tac tgt ggg gac aac acc acc cac ggc acc     3227
 Tyr Ile Leu Ala Gln Asp Tyr Cys Gly Asp Asn Thr Thr His Gly Thr
     960                 965                 970

 ttc cgc atc gtc acc gag aac atc ccc tgt ggg acc acc ggc acc acc     3275
 Phe Arg Ile Val Thr Glu Asn Ile Pro Cys Gly Thr Thr Gly Thr Thr
 975                 980                 985                 990

 tgc tcc aag gcc atc aag ctc ttc gtg gag agc tac gag ctg atc ctc     3323
 Cys Ser Lys Ala Ile Lys Leu Phe Val Glu Ser Tyr Glu Leu Ile Leu
                 995                1000                1005

 caa gag ggg acc ttt aag gcg gtg gcg aga ggg ccg ggt ggg gac cca     3371
 Gln Glu Gly Thr Phe Lys Ala Val Ala Arg Gly Pro Gly Gly Asp Pro
            1010                1015                1020

 ccc tac aag ata cgc tac atg ggg atc ttc ctg gtc atc gag acc cac     3419
 Pro Tyr Lys Ile Arg Tyr Met Gly Ile Phe Leu Val Ile Glu Thr His
        1025                1030                1035

 ggg atg gcc gtg tcc tgg gac cgg aag acc agc gtg ttc atc cga ctg     3467
 Gly Met Ala Val Ser Trp Asp Arg Lys Thr Ser Val Phe Ile Arg Leu
    1040                1045                1050

 cac cag gac tac aag ggc agg gtc tgc ggc ctg tgc ggg aac ttc gac     3515
 His Gln Asp Tyr Lys Gly Arg Val Cys Gly Leu Cys Gly Asn Phe Asp
1055                1060                1065                1070

 gac aat gcc atc aat gac ttt gcc acg cgt agc cgg tcc gtg gtg ggg     3563
 Asp Asn Ala Ile Asn Asp Phe Ala Thr Arg Ser Arg Ser Val Val Gly
                1075                1080                1085

 gac gca ctg gag ttt ggg aac agc tgg aag ctc tcc ccc tcc tgc ccg     3611
 Asp Ala Leu Glu Phe Gly Asn Ser Trp Lys Leu Ser Pro Ser Cys Pro
            1090                1095                1100

 gac gcc ctg gca ccc aag gac ccc tgc acg gcc aac ccc ttc cgc aag     3659
 Asp Ala Leu Ala Pro Lys Asp Pro Cys Thr Ala Asn Pro Phe Arg Lys
        1105                1110                1115

 tcc tgg gcc cag aag cag tgc agc atc ctc cac ggc ccc acc ttc gcc     3707
 Ser Trp Ala Gln Lys Gln Cys Ser Ile Leu His Gly Pro Thr Phe Ala
    1120                1125                1130

 gcc tgc cgc tcc cag gtt gac tcc acc aag tac tac gag gcc tgc gtg     3755
 Ala Cys Arg Ser Gln Val Asp Ser Thr Lys Tyr Tyr Glu Ala Cys Val
1135                1140                1145                1150

 aac gac gcg tgt gcc tgc gac tcg ggt ggc gac tgc gag tgt ttc tgc     3803
 Asn Asp Ala Cys Ala Cys Asp Ser Gly Gly Asp Cys Glu Cys Phe Cys
                1155                1160                1165

 acg gct gtg gct gcc tac gcc cag gcc tgc cac gac gcg ggc ctg tgt     3851
 Thr Ala Val Ala Ala Tyr Ala Gln Ala Cys His Asp Ala Gly Leu Cys
            1170                1175                1180

 gtg tcc tgg cgg act ccg gac acc tgc ccc ttg ttc tgt gac ttc tac     3899
 Val Ser Trp Arg Thr Pro Asp Thr Cys Pro Leu Phe Cys Asp Phe Tyr
        1185                1190                1195

 aac cca cat ggg ggc tgt gag tgg cac tac cag ccc tgc ggg gca ccc     3947
 Asn Pro His Gly Gly Cys Glu Trp His Tyr Gln Pro Cys Gly Ala Pro
    1200                1205                1210

 tgc cta aaa acc tgc cgg aac ccc agt ggg cac tgc ctg gtg gac ctg     3995
 Cys Leu Lys Thr Cys Arg Asn Pro Ser Gly His Cys Leu Val Asp Leu
1215                1220                1225                1230

 cct ggc ctg gaa ggc tgc tac ccg aag tgc cca ccc agc cag ccc ttc     4043
 Pro Gly Leu Glu Gly Cys Tyr Pro Lys Cys Pro Pro Ser Gln Pro Phe
                1235                1240                1245

 ttc aat gag gac cag atg aag tgc gtg gcc cag tgt ggc tgc tac gac     4091
 Phe Asn Glu Asp Gln Met Lys Cys Val Ala Gln Cys Gly Cys Tyr Asp
            1250                1255                1260

 aag gac gga aac tac tat gac gtc ggt gca agg gtc ccc aca gcg gag     4139
 Lys Asp Gly Asn Tyr Tyr Asp Val Gly Ala Arg Val Pro Thr Ala Glu
        1265                1270                1275

 aac tgc cag agc tgt aac tgc aca ccc agt ggc atc cag tgc gct cac     4187
 Asn Cys Gln Ser Cys Asn Cys Thr Pro Ser Gly Ile Gln Cys Ala His
    1280                1285                1290

 agc ctt gag gcc tgc acc tgc acc tat gag gac agg acc tac agc tac     4235
 Ser Leu Glu Ala Cys Thr Cys Thr Tyr Glu Asp Arg Thr Tyr Ser Tyr
1295                1300                1305                1310

 cag gac gtc atc tac aac acc acc gat ggg ctt ggc gcc tgc ttg atc     4283
 Gln Asp Val Ile Tyr Asn Thr Thr Asp Gly Leu Gly Ala Cys Leu Ile
                1315                1320                1325

 gcc atc tgc gga agc aac ggc acc atc atc agg aag gct gtg gca tgt     4331
 Ala Ile Cys Gly Ser Asn Gly Thr Ile Ile Arg Lys Ala Val Ala Cys
            1330                1335                1340

 cct gga act cca gcc aca acg cca ttc acc ttc acc acc gcc tgg gtc     4379
 Pro Gly Thr Pro Ala Thr Thr Pro Phe Thr Phe Thr Thr Ala Trp Val
        1345                1350                1355

 ccc cac tcc acg aca agc                                             4397
 Pro His Ser Thr Thr Ser 
    1360





      <210> 91
      <211> 5735
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(3903)

      <400> 91
 agttcctcag ca    atg tct aca agt gac atc cca tct tcc cct agc atc      48
                  Met Ser Thr Ser Asp Ile Pro Ser Ser Pro Ser Ile
                    1               5                  10

 cag aat aca gaa acc tca tcc ctt gtc agc atg acc tct gcc acc att       96
 Gln Asn Thr Glu Thr Ser Ser Leu Val Ser Met Thr Ser Ala Thr Ile
          15                  20                  25

 ccc agt gtg aga cca act ttt aca agt aca cac aac act ctg aca agt      144
 Pro Ser Val Arg Pro Thr Phe Thr Ser Thr His Asn Thr Leu Thr Ser
      30                  35                  40

 tcc ctc cta acg acg ttc cca ggg acg tat tca ttt tcc tct tcc atg      192
 Ser Leu Leu Thr Thr Phe Pro Gly Thr Tyr Ser Phe Ser Ser Ser Met
  45                  50                  55                  60

 tct gcc agc agt gat ggg acc act cac aca gaa act atc acc tca ctt      240
 Ser Ala Ser Ser Asp Gly Thr Thr His Thr Glu Thr Ile Thr Ser Leu
                  65                  70                  75

 cca gcc agc acc agt aca ctc cac acc aca gct gaa tcc acc aca gca      288
 Pro Ala Ser Thr Ser Thr Leu His Thr Thr Ala Glu Ser Thr Thr Ala
              80                  85                  90

 cac act acc acc acc tca ttc aca act tcc aca act atg gaa tca cct      336
 His Thr Thr Thr Thr Ser Phe Thr Thr Ser Thr Thr Met Glu Ser Pro
          95                 100                 105

 tca tcc agt gta gca act aca agc aca ggt cag acc acc ttc tcc agc      384
 Ser Ser Ser Val Ala Thr Thr Ser Thr Gly Gln Thr Thr Phe Ser Ser
     110                 115                 120

 tct acg gcc aca ttc act gag acc acc aca ttg act cct acg act gac      432
 Ser Thr Ala Thr Phe Thr Glu Thr Thr Thr Leu Thr Pro Thr Thr Asp
 125                 130                 135                 140

 ttt tct gaa gaa act ctc aca aca gcc atg act tct act ccc ccc atc      480
 Phe Ser Glu Glu Thr Leu Thr Thr Ala Met Thr Ser Thr Pro Pro Ile
                 145                 150                 155

 act tct tca atc act ccc acc aat aca gtg act tct atg aca act atg      528
 Thr Ser Ser Ile Thr Pro Thr Asn Thr Val Thr Ser Met Thr Thr Met
             160                 165                 170

 acc tcc tgg ccc aca gcc act aat acg ttg tca tcc ctc acc act aac      576
 Thr Ser Trp Pro Thr Ala Thr Asn Thr Leu Ser Ser Leu Thr Thr Asn
         175                 180                 185

 att tta tct tct aca cct gtc ccg agc aca gag agg acc acc agt cat      624
 Ile Leu Ser Ser Thr Pro Val Pro Ser Thr Glu Arg Thr Thr Ser His
     190                 195                 200

 act aca aac atc aat cct gta tcc acc ttg gtg acc aca ctc ccc act      672
 Thr Thr Asn Ile Asn Pro Val Ser Thr Leu Val Thr Thr Leu Pro Thr
 205                 210                 215                 220

 acc atc acc agg tct aca cct aca tct gag acc acc tac cct att tct      720
 Thr Ile Thr Arg Ser Thr Pro Thr Ser Glu Thr Thr Tyr Pro Ile Ser
                 225                 230                 235

 tcc acc agc act gtc aca gag tcc acg act gaa atc acc tat tcc act      768
 Ser Thr Ser Thr Val Thr Glu Ser Thr Thr Glu Ile Thr Tyr Ser Thr
             240                 245                 250

 act atg aca gag aca tca tcc agt gcc acc tct ctt cca ctc acc tct      816
 Thr Met Thr Glu Thr Ser Ser Ser Ala Thr Ser Leu Pro Leu Thr Ser
         255                 260                 265

 ccc ttg gtc tca acc aca gaa aca gcc aaa act cct acc aca atc ttg      864
 Pro Leu Val Ser Thr Thr Glu Thr Ala Lys Thr Pro Thr Thr Ile Leu
     270                 275                 280

 gta acc acc acc acc aag acc acc tca cat agt acc acc agc ttc act      912
 Val Thr Thr Thr Thr Lys Thr Thr Ser His Ser Thr Thr Ser Phe Thr
 285                 290                 295                 300

 tct tca acc gtc tac tcc aca gcc agc aca cac acc act gcc atc act      960
 Ser Ser Thr Val Tyr Ser Thr Ala Ser Thr His Thr Thr Ala Ile Thr
                 305                 310                 315

 tca gtt ccc act acc ttg ggt acc atg gtg act tct aca tcc agg atc     1008
 Ser Val Pro Thr Thr Leu Gly Thr Met Val Thr Ser Thr Ser Arg Ile
             320                 325                 330

 cca tct act gtg agt acg agt atc cct acc tca caa cca aaa acc gtc     1056
 Pro Ser Thr Val Ser Thr Ser Ile Pro Thr Ser Gln Pro Lys Thr Val
         335                 340                 345

 aat tcc tca tct ggg ggc atc act ggt tca tta cct atg atg aca gac     1104
 Asn Ser Ser Ser Gly Gly Ile Thr Gly Ser Leu Pro Met Met Thr Asp
     350                 355                 360

 ctt acc tca ggg tac acc gtc tcc agt atg tct gca att ccc aca act     1152
 Leu Thr Ser Gly Tyr Thr Val Ser Ser Met Ser Ala Ile Pro Thr Thr
 365                 370                 375                 380

 gtc att cct aca tct ctc act gtc cag aat aca gaa acc tca atc ttt     1200
 Val Ile Pro Thr Ser Leu Thr Val Gln Asn Thr Glu Thr Ser Ile Phe
                 385                 390                 395

 gtc agc atg acc tct gcc acc act ccc agt ggg aga cca act ttc aca     1248
 Val Ser Met Thr Ser Ala Thr Thr Pro Ser Gly Arg Pro Thr Phe Thr
             400                 405                 410

 agt act gtg aac act ccc aca agg tcc ctc ctg aca agc ttt cca acg     1296
 Ser Thr Val Asn Thr Pro Thr Arg Ser Leu Leu Thr Ser Phe Pro Thr
         415                 420                 425

 aca cat tta ttc tct tct tcc atg tct gaa agc agt gct ggg acc act     1344
 Thr His Leu Phe Ser Ser Ser Met Ser Glu Ser Ser Ala Gly Thr Thr
     430                 435                 440

 cac aca gag agt atc tcc tca cct cca gcc acc acc agt aca ctc cac     1392
 His Thr Glu Ser Ile Ser Ser Pro Pro Ala Thr Thr Ser Thr Leu His
 445                 450                 455                 460

 aca aca gct gaa tcc acc ccg tcg tgc act acc acc acg tca ttc atc     1440
 Thr Thr Ala Glu Ser Thr Pro Ser Cys Thr Thr Thr Thr Ser Phe Ile
                 465                 470                 475

 aca tcc aca act atg gaa cca ctt tca acc att gta gca acg aca ggc     1488
 Thr Ser Thr Thr Met Glu Pro Leu Ser Thr Ile Val Ala Thr Thr Gly
             480                 485                 490

 aca gtt aag acc acc gtc acc agc tcc aca gcc aca ttc cgg gag acc     1536
 Thr Val Lys Thr Thr Val Thr Ser Ser Thr Ala Thr Phe Arg Glu Thr
         495                 500                 505

 acc aca ctg act tct aca act gac atc tcc aca gaa tct ctc atg aca     1584
 Thr Thr Leu Thr Ser Thr Thr Asp Ile Ser Thr Glu Ser Leu Met Thr
     510                 515                 520

 gca atg act tct act acc cga ctc act tct gca atc act tcc aag act     1632
 Ala Met Thr Ser Thr Thr Arg Leu Thr Ser Ala Ile Thr Ser Lys Thr
 525                 530                 535                 540

 aca ttg act tct ttg aag act act gcc tcc cgg ccc aca gcc aat agt     1680
 Thr Leu Thr Ser Leu Lys Thr Thr Ala Ser Arg Pro Thr Ala Asn Ser
                 545                 550                 555

 acg tta tca tca ctc acc agt agc att ttg tct tcc aca ctt gtc ccc     1728
 Thr Leu Ser Ser Leu Thr Ser Ser Ile Leu Ser Ser Thr Leu Val Pro
             560                 565                 570

 agc aca gac atg atc act agt cat acc aca aac ctt acc cgt tca tct     1776
 Ser Thr Asp Met Ile Thr Ser His Thr Thr Asn Leu Thr Arg Ser Ser
         575                 580                 585

 ccc ttg ctt gcc aca ctc cct act acc atc acc agg tct aca cct aca     1824
 Pro Leu Leu Ala Thr Leu Pro Thr Thr Ile Thr Arg Ser Thr Pro Thr
     590                 595                 600

 tct gag acc aca tac cct act tct cct acc agc aca gtg aaa ggc tcc     1872
 Ser Glu Thr Thr Tyr Pro Thr Ser Pro Thr Ser Thr Val Lys Gly Ser
 605                 610                 615                 620

 acg acc agc atc agg tat tcc aca agt atg aca ggt aca ttg tct atg     1920
 Thr Thr Ser Ile Arg Tyr Ser Thr Ser Met Thr Gly Thr Leu Ser Met
                 625                 630                 635

 gag act tct ctc cca ccc acc tct tcc tct ctc cca acc aca gaa aca     1968
 Glu Thr Ser Leu Pro Pro Thr Ser Ser Ser Leu Pro Thr Thr Glu Thr
             640                 645                 650

 gcc acg atg act cct acc aca acc ttg ata acc acc acc cct aat acc     2016
 Ala Thr Met Thr Pro Thr Thr Thr Leu Ile Thr Thr Thr Pro Asn Thr
         655                 660                 665

 acc tcc cat agt acc ccc agc ttc act tct tca acc atc tac tcc aca     2064
 Thr Ser His Ser Thr Pro Ser Phe Thr Ser Ser Thr Ile Tyr Ser Thr
     670                 675                 680

 gtc agc aca tcc aca act gcc atc acc tca cat ttt act acc tca gag     2112
 Val Ser Thr Ser Thr Thr Ala Ile Thr Ser His Phe Thr Thr Ser Glu
 685                 690                 695                 700

 act gcg gtg act ccc aca cct gta acc cca tct tct ctg agt aca gac     2160
 Thr Ala Val Thr Pro Thr Pro Val Thr Pro Ser Ser Leu Ser Thr Asp
                 705                 710                 715

 atc ccg acc aca agc cta cga act ctc acc cct tcg tct gtg ggc acc     2208
 Ile Pro Thr Thr Ser Leu Arg Thr Leu Thr Pro Ser Ser Val Gly Thr
             720                 725                 730

 agc act tca ttg act aca acc aca gac ttt ccc tct ata ccc act gat     2256
 Ser Thr Ser Leu Thr Thr Thr Thr Asp Phe Pro Ser Ile Pro Thr Asp
         735                 740                 745

 atc agt acc tta cca act cga aca cac atc att tca tct tct ccc tcc     2304
 Ile Ser Thr Leu Pro Thr Arg Thr His Ile Ile Ser Ser Ser Pro Ser
     750                 755                 760

 atc caa agt aca gaa acc tca tcc ctt gtg ggc acc acc tct ccc acc     2352
 Ile Gln Ser Thr Glu Thr Ser Ser Leu Val Gly Thr Thr Ser Pro Thr
 765                 770                 775                 780

 atg tcc act gtg aga atg acc ctc aga att act gag aac acc cca atc     2400
 Met Ser Thr Val Arg Met Thr Leu Arg Ile Thr Glu Asn Thr Pro Ile
                 785                 790                 795

 agt tcc ttt agc aca agt att gtt gtt ata cct gaa acc cca aca cag     2448
 Ser Ser Phe Ser Thr Ser Ile Val Val Ile Pro Glu Thr Pro Thr Gln
             800                 805                 810

 acc cct cct gta ctg acg tca gcc act ggg acc caa aca tct cct gca     2496
 Thr Pro Pro Val Leu Thr Ser Ala Thr Gly Thr Gln Thr Ser Pro Ala
         815                 820                 825

 cct act act gtc acc ttt gga agt acg gat tcc tcc acg tcc act ctt     2544
 Pro Thr Thr Val Thr Phe Gly Ser Thr Asp Ser Ser Thr Ser Thr Leu
     830                 835                 840

 cat act ctt act cca tca aca gcc ttg agc acg atc gtg tca aca tca     2592
 His Thr Leu Thr Pro Ser Thr Ala Leu Ser Thr Ile Val Ser Thr Ser
 845                 850                 855                 860

 cag gtt cct att cct agc aca cat tcc tcc acc ctt caa aca act cct     2640
 Gln Val Pro Ile Pro Ser Thr His Ser Ser Thr Leu Gln Thr Thr Pro
                 865                 870                 875

 tct act ccc tca ttg caa act tca ctc aca tct aca agt gag ttc act     2688
 Ser Thr Pro Ser Leu Gln Thr Ser Leu Thr Ser Thr Ser Glu Phe Thr
             880                 885                 890

 aca gaa tct ttc act agg gga agt acg tct aca aat gca atc ttg act     2736
 Thr Glu Ser Phe Thr Arg Gly Ser Thr Ser Thr Asn Ala Ile Leu Thr
         895                 900                 905

 tct ttt agt acc atc atc tgg tcc tca aca ccc act att atc atg tcc     2784
 Ser Phe Ser Thr Ile Ile Trp Ser Ser Thr Pro Thr Ile Ile Met Ser
     910                 915                 920

 tct tct cca tct tct gcc agc ata act cca gtg ttc tcc act acc att     2832
 Ser Ser Pro Ser Ser Ala Ser Ile Thr Pro Val Phe Ser Thr Thr Ile
 925                 930                 935                 940

 cat tct gtt cct tct tca cca tac att ttc agt aca gaa aat gtg ggc     2880
 His Ser Val Pro Ser Ser Pro Tyr Ile Phe Ser Thr Glu Asn Val Gly
                 945                 950                 955

 tcc gct tct atc aca ggc ttt cct agt ctc tct tcc tct gca act acc     2928
 Ser Ala Ser Ile Thr Gly Phe Pro Ser Leu Ser Ser Ser Ala Thr Thr
             960                 965                 970

 agc act tct tca acc agc tcc tct ctg acc aca gct ctc act gaa ata     2976
 Ser Thr Ser Ser Thr Ser Ser Ser Leu Thr Thr Ala Leu Thr Glu Ile
         975                 980                 985

 acc ccc ttt tct tat att tcc ctt ccc tcc acc aca ccc tgt cca gga     3024
 Thr Pro Phe Ser Tyr Ile Ser Leu Pro Ser Thr Thr Pro Cys Pro Gly
     990                 995                1000

 act ata aca att acc ata gtc cct gcc tct ccc act gat cca tgt gtt     3072
 Thr Ile Thr Ile Thr Ile Val Pro Ala Ser Pro Thr Asp Pro Cys Val
1005                1010                1015                1020

 gaa atg gat ccc agc act gaa gct act tct cct ccc acc acc cca tta     3120
 Glu Met Asp Pro Ser Thr Glu Ala Thr Ser Pro Pro Thr Thr Pro Leu
                1025                1030                1035

 aca gtc ttt ccc ttt act acc gaa atg gtc acc tgt cct acc tcc atc     3168
 Thr Val Phe Pro Phe Thr Thr Glu Met Val Thr Cys Pro Thr Ser Ile
            1040                1045                1050

 agt atc caa act act ctt act aca tat atg gac act tct tcc atg atg     3216
 Ser Ile Gln Thr Thr Leu Thr Thr Tyr Met Asp Thr Ser Ser Met Met
        1055                1060                1065

 cca gaa agt gag tcc agc atc tca ccc aat gct tcc agt tcc act ggc     3264
 Pro Glu Ser Glu Ser Ser Ile Ser Pro Asn Ala Ser Ser Ser Thr Gly
    1070                1075                1080

 act ggg act gta ccc aca aac aca gtt ttc aca agt act cga ctg ccc     3312
 Thr Gly Thr Val Pro Thr Asn Thr Val Phe Thr Ser Thr Arg Leu Pro
1085                1090                1095                1100

 acc agt gag acc tgg ctg agc aac agt tct gtg atc ccc cta cct ctt     3360
 Thr Ser Glu Thr Trp Leu Ser Asn Ser Ser Val Ile Pro Leu Pro Leu
                1105                1110                1115

 cct ggc gtc tct acc atc ccg ctc acc atg aaa cca agc agt agc ctc     3408
 Pro Gly Val Ser Thr Ile Pro Leu Thr Met Lys Pro Ser Ser Ser Leu
            1120                1125                1130

 ccg acc atc ctg agg act tca agc aag tca aca cac cca tcc cca ccc     3456
 Pro Thr Ile Leu Arg Thr Ser Ser Lys Ser Thr His Pro Ser Pro Pro
        1135                1140                1145

 acc act agg act tca gag aca cca gtg gcc act acc cag act cct acc     3504
 Thr Thr Arg Thr Ser Glu Thr Pro Val Ala Thr Thr Gln Thr Pro Thr
    1150                1155                1160

 acc ctt aca tca cgc agg aca act cgc atc act tct cag atg acc aca     3552
 Thr Leu Thr Ser Arg Arg Thr Thr Arg Ile Thr Ser Gln Met Thr Thr
1165                1170                1175                1180

 cag tcc acg ttg acc acc act gca ggc acc tgt gac aat ggt ggc acc     3600
 Gln Ser Thr Leu Thr Thr Thr Ala Gly Thr Cys Asp Asn Gly Gly Thr
                1185                1190                1195

 tgg gaa cag ggc cag tgt gct tgc ctt ccg ggg ttt tct ggg gac cgc     3648
 Trp Glu Gln Gly Gln Cys Ala Cys Leu Pro Gly Phe Ser Gly Asp Arg
            1200                1205                1210

 tgt cag ctc cag acc aga tgc cag aat ggg ggt cag tgg gat ggc ctc     3696
 Cys Gln Leu Gln Thr Arg Cys Gln Asn Gly Gly Gln Trp Asp Gly Leu
        1215                1220                1225

 aaa tgc cag tgc ccc agc acc ttc tat ggt tcc agt tgt gag ttt gct     3744
 Lys Cys Gln Cys Pro Ser Thr Phe Tyr Gly Ser Ser Cys Glu Phe Ala
    1230                1235                1240

 gtg gaa cag gtg gat cta gat gca gaa gat ttt tgc aga cat gca ggg     3792
 Val Glu Gln Val Asp Leu Asp Ala Glu Asp Phe Cys Arg His Ala Gly
1245                1250                1255                1260

 ctt cac ctt caa ggg tgt gga gat cct gtc cct gag gaa tgg cag cat     3840
 Leu His Leu Gln Gly Cys Gly Asp Pro Val Pro Glu Glu Trp Gln His
                1265                1270                1275

 cgt ggt gga cta cct ggt cct gct gga gat gcc ctt cag ccc cca gct     3888
 Arg Gly Gly Leu Pro Gly Pro Ala Gly Asp Ala Leu Gln Pro Pro Ala
            1280                1285                1290

 gga gag cga gta tga gcaggtgaag accacgctga aggaggggct gcagaacgcc     3943
 Gly Glu Arg Val 
        1295

 agccaggatg tgaacagctg ccaggactcc cagaccctgt gttttaagcc tgactccatc   4003

 aaggtgaaca acaacagcaa gacagagctg accccggcag ccatctgccg cgcgccgctc   4063

 ccacgggcta tgaagagttc tacttcccct tggtggaggc cacccggctc cgctgtgtca   4123

 ccaaatgcac gtctggggtg gacaacgcca tcgactgtca ccagggccag tgcgttctgg   4183

 agacgagcgg tcccacgtgt cgctgctact ccaccgacac gcactggttc tctggcccgc   4243

 gctgcgaggt ggccgtccac tggagggcgc tggtcggggc ctgacggccg gcgcgcgctg   4303

 ctggtgctgc tgctcgtggc gctgggcgtc cgggcggtgc gctccggatg gtggggcggc   4363

 cagcgccgag gccggtcctg ggaccaggac aggaaatggt tcgagacctg ggatgaggaa   4423

 gtcgtgggca ctttttcaaa ctggggtttc gaggacgacg gaacagacaa ggatacaaat   4483

 ttctatgtgg ccttggagaa cgtgacacca ctatgaaggt gcacatcaag agacccgaga   4543

 tgacctcgtc ctcagtgtga gcctgcgggg ccccttcacc accccctccg ccctgccccg   4603

 gacacaaggg tctgcattgc gtccatttca agaggtgacc ccaggacgcg ggcagcccag   4663

 gctcctgctg ttcttgggca agatgagact gttcccccaa atcccatcct tctccttcca   4723

 acttggctga aacccacctg gagacgcagt tcacgtccag gctcttccac tgtggaatct   4783

 tgggcaagtc agtaacgagc ctcagtttcc tcacctgcaa aacgggtaca gcattcctgt   4843

 atgatacgtc acgccgttgt tgtgaaaacc acatagactt ggtcaattct cggtcctact   4903

 ctgccctccc gtctcagccc tcgtgttgcc attgcctctc tcggatcctc caatcctcac   4963

 gtccttcacc tggtctctgg ccctggttct tattttctct caattcccta ctgcctgttt   5023

 cttactttga acctggaggc agcctgcagc cccatcccat ctcctgccct ctcctgatct   5083

 aactccctgc tgcatctctt gctcccattc cttagacgtc ctcccctttt gaccccgttc   5143

 cttcatccat cctgcacccc agtcccccag ccctaaatcc tccctcctct cctcacatcc   5203

 tggcccctag caaggtatag atagcctctg tgtcttagga taccccgggt gctgttccct   5263

 cggtcatcct gttgcccagt tccccgtttc tcttgctctc attcctgtat cctttcccct   5323

 tttgagcccg tccattcatc ggttctgccc ccgactcccc cagccctaaa taccccagct   5383

 gctgttcccc ccatcaccct gctgcccaat tctttattct ccaccccttt ctctcacccc   5443

 tggagccctg cgggtggggg cagggcatga gttccccagt ccccaaggaa aggcagcccc   5503

 ctcagtctcc ctcctcctca ttcccttcca tctccctccc ctctgccttt taaacccatc   5563

 ccctccgatt cccctcctcc cccctctctc cctggtgtca cctggattcc tgcagtaatt   5623

 ctgagccctt gaaatcctca gtcgccttgg cggggaagat tggctttggg gacaggaggt   5683

 cggcacatct ccaggtcttc atgtgcgcaa tatagagttt attgtaaaaa gc           5735




      <210> 92
      <211> 748
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (202)..(456)

      <400> 92
 tggaagatga ggctcacctt ctgcacagcc aataggtcat tgtcatggga acactgacca     60

 ccagcaccaa cctccatccc ccgccggggg cacgtgcctt tatcacccat ttcctaggtt    120

 ttgttgtggt tcccaggcgg tgccttcgag actggctcag cctccatctt cgatgggtcc    180

 tccctggctg cctatgagga c  atg ctg gtt gtg atc gtc cag tac cgg ctg     231
                          Met Leu Val Val Ile Val Gln Tyr Arg Leu
                            1               5                  10

 gga ata ttt ggc ttc ttc acc aca tgg gat cag cac gct ccc ggg aac      279
 Gly Ile Phe Gly Phe Phe Thr Thr Trp Asp Gln His Ala Pro Gly Asn
                  15                  20                  25

 tgg gcc ttc aag gac cag gtg gct gct cta tcc tgg gtc cag aag aac      327
 Trp Ala Phe Lys Asp Gln Val Ala Ala Leu Ser Trp Val Gln Lys Asn
              30                  35                  40

 atc gag ttc ttc ggt ggg gac ccc agc tct gtg acc atc ttt gat tct      375
 Ile Glu Phe Phe Gly Gly Asp Pro Ser Ser Val Thr Ile Phe Asp Ser
          45                  50                  55

 gtc tcc cat ggc cga agg ctt att cca caa agc cgt cat gga gag tgg      423
 Val Ser His Gly Arg Arg Leu Ile Pro Gln Ser Arg His Gly Glu Trp
      60                  65                  70

 ggt ggc cat cat cct tta cct gaa ggc cca tga ttatgaga agagtgagga      474
 Gly Gly His His Pro Leu Pro Glu Gly Pro 
  75                  80

 cgtacgaata ctgttaacac cttgccagct tcctctcctc agttagggga gaatgtgttc    534

 aggcaccttc tcaccatgtg ccatctatcc cacgatattt gtcatctgtc tcttaattat    594

 ctactacaga gtgaggccct agagaccagg atctctctgt ccttcaggcc cccagcataa    654

 taagtggtat atatcaggca gctataaatg ttctggatga atgagctaat gaatgagctg    714

 tttcattcaa tgcatattaa ttaaaaaaaa aaaa                                748




      <210> 93
      <211> 1947
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (901)..(1524)

      <400> 93
 tgccccaaga aacaaagagg gggaatagat caattgacat gaaatttggg ggttcctaat     60

 ttctctatgt aattctgcaa gtctgctgtc aatcctcctg acttttccat ccaaaatctc    120

 ccgggaccac ttcctacccc agaactcccc ccgcccagcc cccactgccc cccacccacc    180

 cctccaaccg ccagacttcc cacactcccc gcatcagtgc acggcccccg aggactccac    240

 atttcttggg gggtccccag gagacgggca aagatgatcc ctaggtgtgc tccggtgggg    300

 gggtccccaa gatcttcctt ccaggagcac accagggagt caggctactc gtgggggcat    360

 gtctgctcag ctaccggcca tctccaatgt ggccaaactc cttcctcact ctggctgggc    420

 caacacacag taagtaaggt gtatcgggaa tgggtggggt atggggagca tcgtggctca    480

 cgctgcgggg gccgtgggga caggcgccaa ggaggccagc ctcacaaggg catctctgtc    540

 atggtggaaa gatggaatta ggcctgggac acaccccgcc cacctacggg tgtatcccaa    600

 atgccgccgg ccgcacactc aggccgcacc atctgagccc cctcctctga gaggcagggc    660

 acagacaggg ccgaggggca gtggagatgg gaacaggagg ggggctcaga ccatgaaaac    720

 attggagaat cttagcggga ctttggcctg atccatacag atatcgtagt tgcttagata    780

 tgcttattgt tttcatctaa ttttgtgggg gtgtgcgtgt gtgtgcgcat gtgtgtgtgc    840

 aggtgggtgc ttgcgtgtgc aacgtgtgtg ctgcgtgttt gtgtgctgtg agctgtgttc    900
                                                                 
 atg tat gtg ctg cgc atg agt gtg tgt gct gtg tgt gca tgt gtg tgc      948
 Met Tyr Val Leu Arg Met Ser Val Cys Ala Val Cys Ala Cys Val Cys
   1               5                  10                  15

 tgt gtg ttt gtg tgt gct gtg ttc atg tgt gct gtg cat gcg tgt gtg      996
 Cys Val Phe Val Cys Ala Val Phe Met Cys Ala Val His Ala Cys Val
              20                  25                  30

 ctg tgt gca tgt gtg tgc tgt gtg ctg tgt tca tgt gtg tgc tgt gtg     1044
 Leu Cys Ala Cys Val Cys Cys Val Leu Cys Ser Cys Val Cys Cys Val
          35                  40                  45

 tgc atg tgc tgt gtg cat gtg tgt gct gtg ttt gtg tgt gtg ctg tgt     1092
 Cys Met Cys Cys Val His Val Cys Ala Val Phe Val Cys Val Leu Cys
      50                  55                  60

 gtg ctg tgt tcg tgt gtg ctg tgt tcg cgt gtg tgt gct gtg tgt gca     1140
 Val Leu Cys Ser Cys Val Leu Cys Ser Arg Val Cys Ala Val Cys Ala
  65                  70                  75                  80

 tgt gtg tgc tgt gtc ttt gtg tgt gtg ctg tgt gct agt gtg ctg tgt     1188
 Cys Val Cys Cys Val Phe Val Cys Val Leu Cys Ala Ser Val Leu Cys
                  85                  90                  95

 gtg cat gtg tgt gcg tgt gct gtg cgt ttg tgt gct gtg tgc tcg tgt     1236
 Val His Val Cys Ala Cys Ala Val Arg Leu Cys Ala Val Cys Ser Cys
             100                 105                 110

 gtg tgc tgt gtg tgc gtg tgt gct gtg cgt ttg tgt gtg cgt gtg cgt     1284
 Val Cys Cys Val Cys Val Cys Ala Val Arg Leu Cys Val Arg Val Arg
         115                 120                 125

 ttg cgt gtg tgc tgt gtg tgc atg tgt gtg cgt gtg tgt gcc gtg cgt     1332
 Leu Arg Val Cys Cys Val Cys Met Cys Val Arg Val Cys Ala Val Arg
     130                 135                 140

 ttg tgt gct gtg tgt gca tgt gtg tgc gtg tgt gtg ctg tgc gtt tgt     1380
 Leu Cys Ala Val Cys Ala Cys Val Cys Val Cys Val Leu Cys Val Cys
 145                 150                 155                 160

 gtg tgt gct gtg tgc tca tct gtg tgc tgt gtg tgc tgt gcg ttt gtg     1428
 Val Cys Ala Val Cys Ser Ser Val Cys Cys Val Cys Cys Ala Phe Val
                 165                 170                 175

 tgt gtg ctg tat gct cgt gtg tgt gct gtg ctc gtg tgt gtg ctg tgt     1476
 Cys Val Leu Tyr Ala Arg Val Cys Ala Val Leu Val Cys Val Leu Cys
             180                 185                 190

 tca tgc gtg tgc tgt gtg ttg tgt gtg tgt agc tgc ggg gat gca taa     1524
 Ser Cys Val Cys Cys Val Leu Cys Val Cys Ser Cys Gly Asp Ala 
         195                 200                 205

 agtatgagtg ctttttagga tgggaattga gatgtaagat ttgggggtga gggtcgtgcc   1584

 aattacattt catttgcatg gattttggtt ttcatgctct gtcctcccct cctttggtct   1644

 tactgggtcc ctctgactgc tctgtgattt ttagtgatgg aaaagggagt gaggagccag   1704

 tctgggttgt tgctattttc ggatggccag tttaccctga aaattcccgt gagaagggag   1764

 atggcggtag cagcgacgtg cccacctgtg atttctgggg tccttctttt ctctttgctg   1824

 gttcagggac tcaagtccag gccaatttga ctcaaagtcc aagggagaag agaaagaggg   1884

 gggtggggag tgccaaattc ctttattttg ccaattgttt ctcagccaat tcgtttttaa   1944

 tac                                                                 1947


      <210> 94
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 94
 Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu
   1               5                  10                  15    
 Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val
              20                  25                  30        
 Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu
          35                  40                  45            
 Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu
      50                  55                  60                
 His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys
  65                  70                  75                  80
 Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile
                  85                  90                  95    
 Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu
             100                 105                 110        
 Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly
         115                 120                 125            
 Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu
     130                 135                 140                
 Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
 145                 150                 155                 160
 Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp
                 165                 170                 175    
 Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser
             180                 185                 190        
 Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
         195                 200                 205            
 Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp
     210                 215                 220                
 Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala
 225                 230                 235                 240
 Leu Pro Thr Glu Ala Leu Ala Pro Cys Val Pro Cys Ser Thr
                 245                 250                



      <210> 95
      <211> 353
      <212> PRT
      <213> Homo sapiens


      <400> 95
 Met Ala Ala Thr Lys Arg Lys Arg Arg Gly Gly Phe Ala Val Gln Ala
   1               5                  10                  15    
 Lys Lys Pro Lys Arg Asn Glu Ile Asp Ala Glu Pro Pro Ala Lys Arg
              20                  25                  30        
 His Ala Thr Ala Glu Glu Val Glu Glu Glu Glu Arg Asp Arg Ile Pro
          35                  40                  45            
 Gly Pro Val Cys Lys Gly Lys Trp Lys Asn Lys Glu Arg Ile Leu Ile
      50                  55                  60                
 Phe Ser Ser Arg Gly Ile Asn Phe Arg Thr Arg His Leu Met Gln Asp
  65                  70                  75                  80
 Leu Arg Met Leu Met Pro His Ser Lys Ala Asp Thr Lys Met Asp Arg
                  85                  90                  95    
 Lys Asp Lys Leu Phe Val Ile Asn Glu Val Cys Glu Met Lys Asn Cys
             100                 105                 110        
 Asn Lys Cys Ile Tyr Phe Glu Ala Lys Lys Lys Gln Asp Leu Tyr Met
         115                 120                 125            
 Trp Leu Ser Asn Ser Pro His Gly Pro Ser Ala Lys Phe Leu Val Gln
     130                 135                 140                
 Asn Ile His Thr Leu Ala Glu Leu Lys Met Thr Gly Asn Cys Leu Lys
 145                 150                 155                 160
 Gly Ser Arg Pro Leu Leu Ser Phe Asp Pro Ala Phe Asp Glu Leu Pro
                 165                 170                 175    
 His Tyr Ala Leu Leu Lys Glu Leu Leu Ile Gln Ile Phe Ser Thr Pro
             180                 185                 190        
 Arg Tyr His Pro Lys Ser Gln Pro Phe Val Asp His Val Phe Thr Phe
         195                 200                 205            
 Thr Ile Leu Asp Asn Arg Ile Trp Phe Arg Asn Phe Gln Ile Ile Glu
     210                 215                 220                
 Glu Asp Ala Ala Leu Val Glu Ile Gly Pro Arg Phe Val Leu Asn Leu
 225                 230                 235                 240
 Ile Lys Ile Phe Gln Gly Ser Phe Gly Gly Pro Thr Leu Tyr Glu Asn
                 245                 250                 255    
 Pro His Tyr Gln Ser Pro Asn Met His Arg Arg Val Ile Arg Ser Ile
             260                 265                 270        
 Thr Ala Ala Lys Tyr Arg Glu Lys Gln Gln Val Lys Asp Val Gln Lys
         275                 280                 285            
 Leu Arg Lys Lys Glu Pro Lys Thr Leu Leu Pro His Asp Pro Thr Ala
     290                 295                 300                
 Asp Val Phe Val Thr Pro Ala Glu Glu Lys Pro Ile Glu Ile Gln Trp
 305                 310                 315                 320
 Val Lys Pro Glu Pro Lys Val Asp Leu Lys Ala Arg Lys Lys Arg Ile
                 325                 330                 335    
 Tyr Lys Arg Gln Arg Lys Met Lys Gln Arg Met Asp Ser Gly Lys Thr
             340                 345                 350        
 Lys
    



      <210> 96
      <211> 410
      <212> PRT
      <213> Homo sapiens


      <400> 96
 Met Cys Ser Thr Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro
   1               5                  10                  15    
 Cys Phe Leu Leu Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly
              20                  25                  30        
 Gln Ser Ser Arg Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met
          35                  40                  45            
 Leu Val Ala Glu Gly Glu Thr Leu Leu Leu Arg Cys Met Val Val Gly
      50                  55                  60                
 Ser Cys Thr Asp Gly Met Ile Lys Trp Val Lys Ile Ala Leu Ala Ser
  65                  70                  75                  80
 Phe Tyr Glu Asp Gly Gly Asp Glu Asp Ile Val Thr Ile Ser Gln Ala
                  85                  90                  95    
 Thr Pro Ser Ser Val Ser Arg Gly Thr Ala Pro Ser Asp Asn Arg Val
             100                 105                 110        
 Thr Ser Phe Arg Asp Leu Ile His Asp Gln Asp Glu Asp Glu Glu Glu
         115                 120                 125            
 Glu Glu Gly Gln Arg Phe Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln
     130                 135                 140                
 Gln Ile Val Gly Pro Pro Arg Lys Lys Ser Pro Asn Glu Leu Val Asp
 145                 150                 155                 160
 Asp Leu Phe Lys Gly Ala Lys Glu His Gly Ala Val Ala Val Glu Arg
                 165                 170                 175    
 Val Thr Lys Ser Pro Gly Glu Thr Ser Lys Pro Arg Pro Phe Ala Gly
             180                 185                 190        
 Gly Gly Tyr Arg Leu Gly Ala Ala Pro Glu Glu Glu Ser Ala Tyr Val
         195                 200                 205            
 Ala Gly Glu Lys Arg Gln His Ser Ser Gln Asp Val His Val Val Leu
     210                 215                 220                
 Lys Leu Trp Lys Ser Gly Phe Ser Leu Asp Asn Gly Glu Leu Arg Ser
 225                 230                 235                 240
 Tyr Gln Asp Pro Ser Asn Ala Gln Phe Leu Glu Ser Ile Arg Arg Gly
                 245                 250                 255    
 Glu Val Pro Ala Glu Leu Arg Arg Leu Ala His Gly Gly Gln Val Asn
             260                 265                 270        
 Leu Asp Met Glu Asp His Arg Asp Glu Asp Phe Val Lys Pro Lys Gly
         275                 280                 285            
 Ala Leu Gln Ala Phe Thr Gly Glu Gly Gln Lys Leu Gly Ser Thr Ala
     290                 295                 300                
 Pro Gln Val Leu Ser Thr Ser Ser Pro Ala Gln Gln Ala Glu Asn Glu
 305                 310                 315                 320
 Ala Lys Ala Ser Ser Ser Ile Leu Ile Asn Glu Ser Glu Pro Thr Thr
                 325                 330                 335    
 Asn Ile Gln Ile Arg Leu Ala Asp Gly Gly Arg Leu Val Gln Lys Phe
             340                 345                 350        
 Asn His Ser His Arg Ile Ser Asp Ile Arg Leu Phe Ile Val Asp Ala
         355                 360                 365            
 Arg Pro Ala Met Ala Ala Thr Ser Phe Ile Leu Met Thr Thr Phe Pro
     370                 375                 380                
 Asn Lys Glu Leu Ala Asp Glu Ser Gln Thr Leu Lys Glu Ala Asn Leu
 385                 390                 395                 400
 Leu Asn Ala Val Ile Val Gln Arg Leu Thr
                 405                 410



      <210> 97
      <211> 379
      <212> PRT
      <213> Homo sapiens


      <400> 97
 Met Cys Ser Thr Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro
   1               5                  10                  15    
 Cys Phe Leu Leu Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly
              20                  25                  30        
 Gln Ser Ser Arg Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met
          35                  40                  45            
 Leu Val Ala Glu Gly Glu Thr Leu Leu Leu Arg Cys Met Val Val Gly
      50                  55                  60                
 Ser Cys Thr Asp Gly Met Ile Lys Trp Val Lys Ile Ala Leu Ala Ser
  65                  70                  75                  80
 Phe Tyr Glu Asp Gly Gly Asp Glu Asp Ile Val Thr Ile Ser Gln Ala
                  85                  90                  95    
 Thr Pro Ser Ser Val Ser Arg Gly Thr Ala Pro Ser Asp Asn Arg Val
             100                 105                 110        
 Thr Ser Phe Arg Asp Leu Ile His Asp Gln Asp Glu Asp Glu Glu Glu
         115                 120                 125            
 Glu Glu Gly Gln Arg Phe Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln
     130                 135                 140                
 Gln Ile Val Gly Pro Pro Arg Lys Lys Ser Pro Asn Glu Leu Val Asp
 145                 150                 155                 160
 Asp Leu Phe Lys Gly Ala Lys Glu His Gly Ala Val Ala Val Glu Arg
                 165                 170                 175    
 Val Thr Lys Ser Pro Gly Glu Thr Ser Lys Pro Arg Val His Val Val
             180                 185                 190        
 Leu Lys Leu Trp Lys Ser Gly Phe Ser Leu Asp Asn Gly Glu Leu Arg
         195                 200                 205            
 Ser Tyr Gln Asp Pro Ser Asn Ala Gln Phe Leu Glu Ser Ile Arg Arg
     210                 215                 220                
 Gly Glu Val Pro Ala Glu Leu Arg Arg Leu Ala His Gly Gly Gln Val
 225                 230                 235                 240
 Asn Leu Asp Met Glu Asp His Arg Asp Glu Asp Phe Val Lys Pro Lys
                 245                 250                 255    
 Gly Ala Phe Lys Ala Phe Thr Gly Glu Gly Gln Lys Leu Gly Ser Thr
             260                 265                 270        
 Ala Pro Gln Val Leu Ser Thr Ser Ser Pro Ala Gln Gln Ala Glu Asn
         275                 280                 285            
 Glu Ala Lys Ala Ser Ser Ser Ile Leu Ile Asp Glu Ser Glu Pro Thr
     290                 295                 300                
 Thr Asn Ile Gln Ile Arg Leu Ala Asp Gly Gly Arg Leu Val Gln Lys
 305                 310                 315                 320
 Phe Asn His Ser His Arg Ile Ser Asp Ile Arg Leu Phe Ile Val Asp
                 325                 330                 335    
 Ala Arg Pro Ala Met Ala Ala Thr Ser Phe Ile Leu Met Thr Thr Phe
             340                 345                 350        
 Pro Asn Lys Glu Leu Ala Asp Glu Ser Gln Thr Leu Lys Glu Ala Asn
         355                 360                 365            
 Leu Leu Asn Ala Val Ile Val Gln Arg Leu Thr
     370                 375                



      <210> 98
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 98
 Met Ala Ala Glu Arg Gln Glu Ala Leu Arg Glu Phe Val Ala Val Thr
   1               5                  10                  15    
 Gly Ala Glu Glu Asp Arg Ala Arg Phe Phe Leu Glu Ser Ala Gly Trp
              20                  25                  30        
 Asp Leu Gln Ile Ala Leu Ala Ser Phe Tyr Glu Asp Gly Gly Asp Glu
          35                  40                  45            
 Asp Ile Val Thr Ile Ser Gln Ala Thr Pro Ser Ser Val Ser Arg Gly
      50                  55                  60                
 Thr Ala Pro Ser Asp Asn Arg Val Thr Ser Phe Arg Asp Leu Ile His
  65                  70                  75                  80
 Asp Gln Asp Glu Asp Glu Glu Glu Glu Glu Gly Gln Arg Ser Arg Phe
                  85                  90                  95    
 Tyr Ala Gly Gly Ser Glu Arg Ser Gly Gln Gln Ile Val Gly Pro Pro
             100                 105                 110        
 Arg Lys Lys Ser Pro Asn Glu Leu Val Asp Asp Leu Phe Lys Gly Ala
         115                 120                 125            
 Lys Glu His Gly Ala Val Ala Val Glu Arg Val Thr Lys Ser Pro Gly
     130                 135                 140                
 Glu Thr Ser Lys Pro Arg Pro Phe Ala Gly Gly Gly Tyr Arg Leu Gly
 145                 150                 155                 160
 Ala Ser Thr Arg Gly Arg Val Cys Leu Cys Gly Arg Arg Lys Glu Ala
                 165                 170                 175    
 Ala Phe Gln Pro Arg Cys Ser Cys Ser Ile Glu Thr Leu Glu Glu Trp
             180                 185                 190        
 Ile Gln Pro Gly
         195    



      <210> 99
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 99
 Met Phe Ala Pro Arg Leu Leu Asp Leu Gln Lys Thr Lys Tyr Ala Arg
   1               5                  10                  15    
 Phe Met Asn His Arg Val Pro Ala His Lys Arg Tyr Gln Pro Thr Glu
              20                  25                  30        
 Tyr Glu His Ala Ala Asn Cys Ala Thr His Ala Phe Trp Ile Ile Pro
          35                  40                  45            
 Ser Ile Leu Gly Ser Ser Asn Leu Tyr Phe Leu Ser Asp Asp Asp Trp
      50                  55                  60                
 Glu Thr Ile Ser Ala Trp Ile Tyr Gly Leu Gly Leu Cys Gly Leu Phe
  65                  70                  75                  80
 Val Val Ser Thr Val Phe His Thr Ile Ser Trp Lys Lys Ser His Leu
                  85                  90                  95    
 Arg Trp Gly Phe
             100



      <210> 100
      <211> 580
      <212> PRT
      <213> Homo sapiens


      <400> 100
 Met Arg Pro Trp Leu Arg His Leu Val Leu Gln Ala Leu Arg Asn Ser
   1               5                  10                  15    
 Arg Ala Phe Cys Gly Ser His Gly Lys Pro Ala Pro Leu Pro Val Pro
              20                  25                  30        
 Gln Lys Ile Val Ala Thr Trp Glu Ala Ile Ser Leu Gly Arg Gln Leu
          35                  40                  45            
 Val Pro Glu Tyr Phe Asn Phe Ala His Asp Val Leu Asp Val Trp Ser
      50                  55                  60                
 Arg Leu Glu Glu Ala Gly His Arg Pro Pro Asn Pro Ala Phe Trp Trp
  65                  70                  75                  80
 Val Asn Gly Thr Gly Ala Glu Ile Lys Trp Ser Phe Glu Glu Leu Gly
                  85                  90                  95    
 Lys Gln Ser Arg Lys Ala Ala Asn Val Leu Gly Gly Ala Cys Gly Leu
             100                 105                 110        
 Gln Pro Gly Asp Arg Met Met Leu Val Leu Pro Arg Leu Pro Glu Trp
         115                 120                 125            
 Trp Leu Val Ser Val Ala Cys Met Arg Thr Gly Thr Val Met Ile Pro
     130                 135                 140                
 Gly Val Thr Gln Leu Thr Glu Lys Asp Leu Lys Tyr Arg Leu Gln Ala
 145                 150                 155                 160
 Ser Arg Ala Lys Ser Ile Ile Thr Ser Asp Ser Leu Ala Pro Arg Val
                 165                 170                 175    
 Asp Ala Ile Ser Ala Glu Cys Pro Ser Leu Gln Thr Lys Leu Leu Val
             180                 185                 190        
 Ser Asp Ser Ser Arg Pro Gly Trp Leu Asn Phe Arg Glu Leu Leu Arg
         195                 200                 205            
 Glu Ala Ser Thr Glu His Asn Cys Met Arg Thr Lys Ser Arg Asp Pro
     210                 215                 220                
 Leu Ala Ile Tyr Phe Thr Lys Arg Glu Pro Pro Gly Ala Pro Lys Met
 225                 230                 235                 240
 Val Glu His Ser Gln Ser Ser Tyr Gly Leu Gly Phe Val Ala Ser Gly
                 245                 250                 255    
 Arg Arg Trp Val Ala Leu Thr Glu Ser Asp Ile Phe Trp Asn Thr Thr
             260                 265                 270        
 Asp Thr Gly Trp Val Lys Ala Ala Trp Thr Leu Phe Ser Ala Trp Pro
         275                 280                 285            
 Asn Gly Ser Cys Ile Phe Val His Glu Leu Pro Arg Val Asp Ala Lys
     290                 295                 300                
 Val Ile Leu Asn Thr Leu Ser Lys Phe Pro Ile Thr Thr Leu Cys Cys
 305                 310                 315                 320
 Val Pro Thr Ile Phe Arg Leu Leu Val Gln Glu Asp Leu Thr Arg Tyr
                 325                 330                 335    
 Gln Phe Gln Ser Leu Arg His Cys Leu Thr Gly Gly Glu Ala Leu Asn
             340                 345                 350        
 Pro Asp Val Arg Glu Lys Trp Lys His Gln Thr Gly Val Glu Leu Tyr
         355                 360                 365            
 Glu Gly Tyr Gly Gln Ser Glu Thr Val Val Ile Cys Ala Asn Pro Lys
     370                 375                 380                
 Gly Met Lys Ile Lys Ser Gly Ser Met Gly Lys Ala Ser Pro Pro Tyr
 385                 390                 395                 400
 Asp Val Gln Ile Val Asp Asp Glu Gly Asn Val Leu Pro Pro Gly Glu
                 405                 410                 415    
 Glu Gly Asn Val Ala Val Arg Ile Arg Pro Thr Arg Pro Phe Cys Phe
             420                 425                 430        
 Phe Asn Cys Tyr Leu Asp Asn Pro Glu Lys Thr Ala Ala Ser Glu Gln
         435                 440                 445            
 Gly Asp Phe Tyr Ile Thr Gly Asp Arg Ala Arg Met Asp Lys Asp Gly
     450                 455                 460                
 Tyr Phe Trp Phe Met Gly Arg Asn Asp Asp Val Ile Asn Ser Ser Ser
 465                 470                 475                 480
 Tyr Arg Ile Gly Pro Val Glu Val Glu Ser Ala Leu Ala Glu His Pro
                 485                 490                 495    
 Ala Val Leu Glu Ser Ala Val Val Ser Ser Pro Asp Pro Ile Arg Gly
             500                 505                 510        
 Glu Val Val Lys Ala Phe Ile Val Leu Thr Pro Ala Tyr Ser Ser His
         515                 520                 525            
 Asp Pro Glu Ala Leu Thr Arg Glu Leu Gln Glu His Val Lys Arg Val
     530                 535                 540                
 Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Val Ala Phe Val Ser Glu Leu
 545                 550                 555                 560
 Pro Lys Thr Val Ser Gly Lys Ile Gln Arg Ser Lys Leu Arg Ser Gln
                 565                 570                 575    
 Glu Trp Gly Lys
             580



      <210> 101
      <211> 109
      <212> PRT
      <213> Homo sapiens


      <400> 101
 Met Asp Leu Pro Arg Gly Leu Val Val Ala Trp Ala Leu Ser Leu Trp
   1               5                  10                  15    
 Pro Gly Phe Thr Asp Thr Phe Asn Met Asp Thr Arg Lys Pro Arg Val
              20                  25                  30        
 Ile Pro Gly Ser Arg Thr Ala Phe Phe Gly Tyr Thr Val Gln Gln His
          35                  40                  45            
 Asp Ile Ser Gly Asn Lys Trp Leu Val Val Gly Ala Pro Leu Glu Thr
      50                  55                  60                
 Asn Gly Tyr Gln Lys Thr Gly Asp Val Tyr Lys Cys Pro Val Ile His
  65                  70                  75                  80
 Gly Asn Cys Thr Lys Leu Asn Leu Gly Asn Val Gly Trp Trp Ser Leu
                  85                  90                  95    
 His Asn Glu Ala Ser Gly Cys Leu Thr Gln Gly Arg Leu
             100                 105                



      <210> 102
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 102
 Met Gln Lys Leu Glu Leu Gly Arg Tyr Asn Glu Thr His Ala Ile Ala
   1               5                  10                  15    
 Lys Trp Leu Leu Glu Lys Gln Glu Leu Gly Gly Gly Phe Arg Ser Thr
              20                  25                  30        
 Gln Thr Thr Val Val Ala Leu Glu Ala Leu Thr Arg Phe Arg Glu Ala
          35                  40                  45            
 Val Pro Phe Lys Gly Ile Gln Asp Leu His Val Gln Ile Arg Ala Pro
      50                  55                  60                
 Lys Thr Ala Leu Asn Val Asn Trp Tyr Ile Asp His Ser Asn Ala Tyr
  65                  70                  75                  80
 Gln Gln Arg Ser Ala Lys Phe Leu Ala Gln Asp Asp Leu Glu Ile Lys
                  85                  90                  95    
 Ala Ser Gly Asn Gly Arg Gly Thr Ile Ser Ile Leu Thr Met Tyr His
             100                 105                 110        
 Lys Ser Pro Glu Ser Arg Glu Asp Asn Cys Asn Leu Tyr His Leu Asn
         115                 120                 125            
 Ala Thr Leu His Ser Ala Leu Glu Glu Asn Lys Lys Gly Gly Glu Thr
     130                 135                 140                
 Phe Arg Leu Arg Met Glu Thr Arg Phe Gln Asn Asn
 145                 150                 155    



      <210> 103
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 103
 Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val
   1               5                  10                  15    
 Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val
              20                  25                  30        
 Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly
          35                  40                  45            
 Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val
      50                  55                  60                
 Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg
  65                  70                  75                  80
 Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly
                  85                  90                  95    
 Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu
             100                 105                 110        
 Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala
         115                 120                 125            
 Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr
     130                 135                 140                
 Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala Met
 145                 150                 155                 160
 Ile Pro Pro Pro Gln Ser Ser Val Arg Lys Pro Arg Tyr Val Arg Arg
                 165                 170                 175    
 Glu Arg Pro Leu Asp Arg Ala Thr Asp Pro Ala Ala Phe Pro Gly Glu
             180                 185                 190        
 Ala Arg Ile Ser Asn Val
         195            



      <210> 104
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 104
 Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln
   1               5                  10                  15    
 Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser
              20                  25                  30        
 Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly
          35                  40                  45            
 Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser
      50                  55                  60                
 Gly Ser Arg Tyr Trp Val Arg Leu Gly Glu His Ser Leu Ser Gln Leu
  65                  70                  75                  80
 Asp Trp Thr Glu Gln Ile Arg His Ser Gly Phe Ser Val Thr His Pro
                  85                  90                  95    
 Gly Tyr Leu Gly Ala Ser Thr Ser His Glu His Asp Leu Arg Leu Leu
             100                 105                 110        
 Arg Leu Arg Leu Pro Val Arg Val Thr Ser Ser Val Gln Pro Leu Pro
         115                 120                 125            
 Leu Pro Asn Asp Cys Ala Thr Ala Gly Thr Glu Cys His Val Ser Gly
     130                 135                 140                
 Trp Gly Ile Thr Asn His Pro Arg Asn Pro Phe Pro Asp Leu Leu Gln
 145                 150                 155                 160
 Cys Leu Asn Leu Ser Ile Val Ser His Ala Thr Cys His Gly Val Tyr
                 165                 170                 175    
 Pro Gly Arg Ile Thr Ser Asn Met Val Cys Ala Gly Gly Val Pro Gly
             180                 185                 190        
 Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly
         195                 200                 205            
 Val Leu Gln Gly Leu Val Ser Trp Gly Ser Val Gly Pro Cys Gly Gln
     210                 215                 220                
 Asp Gly Ile Pro Gly Val Tyr Thr Tyr Ile Cys Ser Ser Thr Leu Val
 225                 230                 235                 240
 Gly Leu Gly Thr Ser Trp Asn Phe Asn Ser Cys Gln Pro Phe
                 245                 250                



      <210> 105
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 105
 Met Ile Trp Lys Arg Ser Ala Val Leu Arg Phe Tyr Ser Val Cys Gly
   1               5                  10                  15    
 Leu Leu Leu Gln Ala Ala Ala Ser Lys Asn Lys Val Lys Gly Ser Gln
              20                  25                  30        
 Gly Gln Phe Pro Leu Thr Gln Asn Val Thr Val Val Glu Gly Gly Thr
          35                  40                  45            
 Ala Ile Leu Thr Cys Arg Val Asp Gln Asn Asp Asn Thr Ser Leu Gln
      50                  55                  60                
 Trp Ser Asn Pro Ala Gln Gln Thr Leu Tyr Phe Asp Asp Lys Lys Ala
  65                  70                  75                  80
 Leu Arg Asp Asn Arg Ile Glu Leu Val Arg Ala Ser Trp His Glu Leu
                  85                  90                  95    
 Ser Ile Ser Val Ser Asp Val Ser Leu Ser Asp Glu Gly Gln Tyr Thr
             100                 105                 110        
 Cys Ser Leu Phe Thr Met Pro Val Lys Thr Ser Lys Ala Tyr Leu Thr
         115                 120                 125            
 Val Leu Gly Val Pro Glu Lys Pro Gln Ile Ser Gly Phe Ser Ser Pro
     130                 135                 140                
 Val Met Glu Gly Asp Leu Met Gln Leu Thr Cys Lys Thr Ser Gly Ser
 145                 150                 155                 160
 Lys Pro Ala Ala Asp Ile Arg Trp Phe Lys Asn Asp Lys Glu Ile Lys
                 165                 170                 175    
 Asp Val Lys Tyr Leu Lys Glu Glu Asp Ala Asn Arg Lys Thr Phe Thr
             180                 185                 190        
 Val Ser Ser Thr Leu Asp Phe Arg Val Asp Arg Ser Asp Asp Gly Val
         195                 200                 205            
 Ala Val Ile Cys Arg Val Asp His Glu Ser Leu Asn Ala Thr Pro Gln
     210                 215                 220                
 Val Ala Met Gln Val Leu Glu Ile His Tyr Thr Pro Ser Val Lys Ile
 225                 230                 235                 240
 Ile Pro Ser Thr Pro Phe Pro Gln Glu Gly Gln Pro Leu Ile Leu Thr
                 245                 250                 255    
 Cys Glu Ser Lys Gly Lys Pro Leu Pro Glu Pro Val Leu Trp Thr Lys
             260                 265                 270        
 Asp Gly Gly Glu Leu Pro Asp Pro Asp Arg Met Val Val Ser Gly Arg
         275                 280                 285            
 Glu Leu Asn Ile Leu Phe Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg
     290                 295                 300                
 Cys Glu Ala Thr Asn Thr Ile Gly Gln Ser Ser Ala Glu Tyr Val Leu
 305                 310                 315                 320
 Ile Val His Asp Pro Asn Ala Leu Ala Gly Gln Asn Gly Pro Asp His
                 325                 330                 335    
 Ala Leu Ile Gly Gly Ile Val Ala Val Val Val Phe Val Thr Leu Cys
             340                 345                 350        
 Ser Ile Phe Leu Leu Gly Arg Tyr Leu Ala Arg His Lys Gly Thr Tyr
         355                 360                 365            
 Leu Thr Asn Glu Ala Lys Gly Ala Glu Asp Ala Pro Asp Ala Asp Thr
     370                 375                 380                
 Ala Ile Ile Asn Ala Glu Gly Ser Gln Val Asn Ala Glu Glu Lys Lys
 385                 390                 395                 400
 Glu Tyr Phe Ile
                



      <210> 106
      <211> 1600
      <212> PRT
      <213> Homo sapiens


      <400> 106
 Met Thr Leu Glu Gly Leu Tyr Leu Ala Arg Gly Pro Leu Ala Arg Leu
   1               5                  10                  15    
 Leu Leu Ala Trp Ser Ala Leu Leu Cys Met Ala Gly Gly Gln Gly Arg
              20                  25                  30        
 Trp Asp Gly Ala Leu Glu Ala Ala Gly Pro Gly Arg Val Arg Arg Arg
          35                  40                  45            
 Gly Ser Pro Gly Ile Leu Gln Gly Cys Val Val Pro Gly Met Leu Gly
      50                  55                  60                
 Asp Pro Phe Gly Val Asp Trp Ala Val Leu Gly Pro Ala Glu Tyr Pro
  65                  70                  75                  80
 Gly Gly Cys Pro His Gly Gln Gly Leu Thr Arg Pro Ile Ser Leu Ser
                  85                  90                  95    
 Pro Lys Ala Glu Cys Val Arg Leu Pro Val Pro Cys Leu Leu Leu Ser
             100                 105                 110        
 Arg Leu Glu Asp Ile Pro Trp Gln Glu Pro Val Cys Arg Thr Arg Ala
         115                 120                 125            
 Cys Gly Glu Gly Phe Cys Ser Gln Pro Asn Leu Cys Thr Cys Ala Asp
     130                 135                 140                
 Gly Thr Leu Ala Pro Ser Cys Gly Val Ser Arg Gly Ser Gly Cys Ser
 145                 150                 155                 160
 Val Ser Cys Met Asn Gly Gly Thr Cys Arg Gly Ala Ser Cys Leu Cys
                 165                 170                 175    
 Gln Lys Gly Tyr Thr Gly Thr Val Cys Gly Gln Pro Ile Cys Asp Arg
             180                 185                 190        
 Gly Cys His Asn Gly Gly Arg Cys Ile Gly Pro Asn Arg Cys Ala Cys
         195                 200                 205            
 Val Tyr Gly Phe Met Gly Pro Gln Cys Glu Arg Asp Tyr Arg Thr Gly
     210                 215                 220                
 Pro Cys Phe Gly Gln Val Gly Pro Glu Gly Cys Gln His Gln Leu Thr
 225                 230                 235                 240
 Gly Leu Val Cys Thr Lys Ala Leu Cys Cys Ala Thr Val Gly Arg Ala
                 245                 250                 255    
 Trp Gly Leu Pro Cys Glu Leu Cys Pro Ala Gln Pro His Pro Cys Arg
             260                 265                 270        
 Arg Gly Phe Ile Pro Asn Ile His Thr Gly Ala Cys Gln Asp Val Asp
         275                 280                 285            
 Glu Cys Gln Ala Val Pro Gly Leu Cys Gln Gly Gly Ser Cys Val Asn
     290                 295                 300                
 Met Val Gly Ser Phe His Cys Arg Cys Pro Val Gly His Arg Leu Ser
 305                 310                 315                 320
 Asp Ser Ser Ala Ala Cys Glu Asp Tyr Arg Ala Gly Ala Cys Phe Ser
                 325                 330                 335    
 Val Leu Phe Gly Gly Arg Cys Ala Gly Asp Leu Ala Gly His Tyr Thr
             340                 345                 350        
 Arg Arg Gln Cys Cys Cys Asp Arg Gly Gln Val Leu Gly Ser Val Ala
         355                 360                 365            
 Arg Ser Leu Ser Cys Val Leu Leu Gly Ala Pro Val Asn Glu Phe Gln
     370                 375                 380                
 Gln Leu Cys Ala Gln Arg Leu Pro Leu Leu Pro Gly His Pro Gly Leu
 385                 390                 395                 400
 Phe Pro Gly Leu Leu Gly Phe Gly Ser Asn Gly Met Gly Pro Pro Leu
                 405                 410                 415    
 Gly Pro Ala Arg Leu Asn Pro His Gly Ser Asp Ala Arg Gly Ile Pro
             420                 425                 430        
 Ser Leu Gly Pro Gly Asn Ser Asn Ile Gly Thr Ala Thr Leu Asn Gln
         435                 440                 445            
 Thr Ile Asp Ile Cys Arg His Phe Thr Asn Leu Cys Leu Asn Gly Arg
     450                 455                 460                
 Cys Leu Pro Thr Pro Ser Ser Tyr Arg Cys Glu Cys Asn Val Gly Tyr
 465                 470                 475                 480
 Thr Gln Asp Val Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Thr Ser
                 485                 490                 495    
 Ser Pro Cys His His Gly Asp Cys Val Asn Ile Pro Gly Thr Tyr His
             500                 505                 510        
 Cys Arg Cys Tyr Pro Gly Phe Gln Ala Thr Pro Thr Arg Gln Ala Cys
         515                 520                 525            
 Val Asp Val Asp Glu Cys Ile Val Ser Gly Gly Leu Cys His Leu Gly
     530                 535                 540                
 Arg Cys Val Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Asn Ala Gly
 545                 550                 555                 560
 Phe Glu Leu Ser Pro Asp Gly Lys Asn Cys Val Ala Ala Ala Pro Gly
                 565                 570                 575    
 Arg Gln Thr His Leu Arg Leu Gly Glu Ala Glu Gly Phe Lys Asp Asn
             580                 585                 590        
 Ser Thr Val Gln Glu Pro Tyr Pro His Ile Thr Asp Pro Gly Arg Pro
         595                 600                 605            
 Ser Gly Val Thr Leu Ala Ser Ala Leu Arg Cys Leu Arg Pro Cys Leu
     610                 615                 620                
 Ser Ser Asp Trp Ser Arg Trp Glu His Ser Pro Ile Trp Ser Pro Leu
 625                 630                 635                 640
 Leu Pro Glu Met Leu Trp Leu Cys Ser Ser Val His Thr Pro Thr Leu
                 645                 650                 655    
 Pro Gly Arg Pro Glu Pro Leu Gly Arg Ala Val Gly Trp Cys Thr Gly
             660                 665                 670        
 Glu Ala Gln Ile Ser Pro Gly Leu Ser Gly His Pro Gly Tyr Pro Glu
         675                 680                 685            
 Ser Gly Ala Leu Leu Glu Gly Gln Ser Arg Gly Ser Pro Glu Ala Arg
     690                 695                 700                
 Ala Gly Ala Asn Arg Gly Asp His Asn Glu Cys Ala Thr Ser Thr Met
 705                 710                 715                 720
 Cys Val Asn Gly Val Cys Leu Asn Glu Asp Trp Gln Leu Leu Leu Pro
                 725                 730                 735    
 Leu Gln Thr Arg Ala Ser Cys Trp Arg Leu Ala Ala Ile Thr Ala Leu
             740                 745                 750        
 Asp Ala Arg His Leu Arg Glu Arg His Cys Thr Asn Thr Glu Gly Ser
         755                 760                 765            
 Phe Arg Cys Gln Cys Leu Gly Gly Leu Ala Val Gly Thr Asp Gly Arg
     770                 775                 780                
 Val Cys Val Asp Thr His Val Arg Ser Thr Cys Tyr Gly Ala Ile Glu
 785                 790                 795                 800
 Lys Gly Ser Cys Ala Arg Pro Phe Pro Gly Thr Val Thr Lys Ser Glu
                 805                 810                 815    
 Cys Cys Cys Ala Asn Pro Asp His Gly Phe Gly Glu Pro Cys Gln Leu
             820                 825                 830        
 Cys Pro Ala Lys Asp Ser Ala Glu Phe Gln Ala Leu Cys Ser Ser Gly
         835                 840                 845            
 Leu Gly Ile Thr Thr Asp Gly Arg Asp Ile Asn Glu Cys Ala Leu Asp
     850                 855                 860                
 Pro Glu Val Cys Ala Asn Gly Val Cys Glu Asn Leu Arg Gly Ser Tyr
 865                 870                 875                 880
 Arg Cys Val Cys Asn Leu Gly Tyr Glu Ala Gly Ala Ser Gly Lys Asp
                 885                 890                 895    
 Cys Thr Asp Val Asp Glu Cys Ala Leu Asn Ser Leu Leu Cys Asp Asn
             900                 905                 910        
 Gly Trp Cys Gln Asn Ser Pro Gly Ser Tyr Ser Cys Ser Cys Pro Pro
         915                 920                 925            
 Gly Phe His Phe Trp Gln Asp Thr Glu Ile Cys Lys Asp Val Asp Glu
     930                 935                 940                
 Cys Leu Ser Ser Pro Cys Val Ser Gly Val Cys Arg Asn Leu Ala Gly
 945                 950                 955                 960
 Ser Tyr Thr Cys Lys Cys Gly Pro Gly Ser Arg Leu Asp Pro Ser Gly
                 965                 970                 975    
 Thr Phe Cys Leu Asp Ser Thr Lys Gly Thr Cys Trp Leu Lys Ile Gln
             980                 985                 990        
 Glu Ser Arg Cys Glu Val Asn Leu Gln Gly Ala Ser Leu Arg Ser Glu
         995                1000                1005            
 Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser Pro Cys Glu Arg Cys
    1010                1015                1020                
 Glu Ile Gly Ser Ile Leu Leu Glu Ala Ser Gln Ala Pro Met Gly Lys
1025                1030                1035                1040
 Ala Leu His Gly Ala Gly Pro Pro Leu Gly Trp His Glu Lys Met Thr
                1045                1050                1055    
 Pro Leu Phe Thr Leu Val Leu Pro Val Ala Asp Ser Thr Pro Glu Val
            1060                1065                1070        
 Thr Val Arg Asn Ser Arg Val Asp Glu Cys Leu Ser Ser Pro Cys Val
        1075                1080                1085            
 Ser Gly Val Cys Arg Asn Leu Ala Gly Ser Tyr Thr Cys Lys Cys Gly
    1090                1095                1100                
 Pro Gly Ser Arg Leu Asp Pro Ser Gly Thr Phe Cys Leu Asp Ser Thr
1105                1110                1115                1120
 Lys Gly Thr Cys Trp Leu Lys Ile Gln Glu Ser Arg Cys Glu Val Asn
                1125                1130                1135    
 Leu Gln Gly Ala Ser Leu Arg Ser Glu Cys Cys Ala Thr Leu Gly Ala
            1140                1145                1150        
 Ala Trp Gly Ser Pro Cys Glu Arg Cys Glu Ile Asp Pro Ala Cys Ala
        1155                1160                1165            
 Arg Gly Phe Ala Arg Met Thr Gly Val Thr Cys Asn Asp Val Asn Glu
    1170                1175                1180                
 Cys Glu Ser Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Thr
1185                1190                1195                1200
 Ala Gly Ser Phe Arg Cys Glu Cys Pro Glu Gly Leu Met Leu Asp Ala
                1205                1210                1215    
 Ser Gly Arg Leu Cys Val Asp Val Arg Leu Glu Pro Cys Phe Leu Arg
            1220                1225                1230        
 Trp Asp Glu Asp Glu Cys Gly Val Thr Leu Pro Gly Lys Tyr Arg Met
        1235                1240                1245            
 Asp Val Cys Cys Cys Ser Ile Gly Ala Val Trp Gly Val Glu Cys Glu
    1250                1255                1260                
 Ala Cys Pro Asp Pro Glu Ser Leu Glu Phe Ala Ser Leu Cys Pro Arg
1265                1270                1275                1280
 Gly Leu Gly Phe Ala Ser Arg Asp Phe Leu Ser Gly Arg Pro Phe Tyr
                1285                1290                1295    
 Lys Asp Val Asn Glu Cys Lys Val Phe Pro Gly Leu Cys Thr His Gly
            1300                1305                1310        
 Thr Cys Arg Asn Thr Val Gly Ser Phe His Cys Ala Cys Ala Gly Gly
        1315                1320                1325            
 Phe Ala Leu Asp Ala Gln Glu Arg Asn Cys Thr Asp Ile Asp Glu Cys
    1330                1335                1340                
 Arg Ile Ser Pro Asp Leu Cys Gly Gln Gly Thr Cys Val Asn Thr Pro
1345                1350                1355                1360
 Gly Ser Phe Glu Cys Glu Cys Phe Pro Gly Tyr Glu Ser Gly Phe Met
                1365                1370                1375    
 Leu Met Lys Asn Cys Met Asp Val Asp Glu Cys Ala Arg Asp Pro Leu
            1380                1385                1390        
 Leu Cys Arg Gly Gly Thr Cys Thr Asn Thr Asp Gly Ser Tyr Lys Cys
        1395                1400                1405            
 Gln Cys Pro Pro Gly His Glu Leu Thr Ala Lys Gly Thr Ala Cys Glu
    1410                1415                1420                
 Asp Ile Asp Glu Cys Ser Leu Ser Asp Gly Leu Cys Pro His Gly Gln
1425                1430                1435                1440
 Cys Val Asn Val Ile Gly Ala Phe Gln Cys Ser Cys His Ala Gly Phe
                1445                1450                1455    
 Gln Ser Thr Pro Asp Arg Gln Gly Cys Val Asp Ile Asn Glu Cys Arg
            1460                1465                1470        
 Val Gln Asn Gly Gly Cys Asp Val His Cys Ile Asn Thr Glu Gly Ser
        1475                1480                1485            
 Tyr Arg Cys Ser Cys Gly Gln Gly Tyr Ser Leu Met Pro Asp Gly Arg
    1490                1495                1500                
 Ala Cys Ala Asp Val Asp Glu Cys Glu Glu Asn Pro Arg Val Cys Asp
1505                1510                1515                1520
 Gln Gly His Cys Thr Asn Met Pro Gly Gly His Arg Cys Leu Cys Tyr
                1525                1530                1535    
 Asp Gly Phe Met Ala Thr Pro Asp Met Arg Thr Cys Val Asp Val Ala
            1540                1545                1550        
 Leu Leu Pro Pro Ala Leu Tyr Pro Gly Pro Gly His Leu Pro His Cys
        1555                1560                1565            
 Leu Pro Gly Thr Gly Gln Ala Leu Gln Val Ser Pro Gly Leu Asp Ala
    1570                1575                1580                
 Val Leu Trp Gly Thr Glu Pro Ala Pro Gln Leu Gly Ile Pro Gly Arg
1585                1590                1595                1600





      <210> 107
      <211> 180
      <212> PRT
      <213> Homo sapiens


      <400> 107
 Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys Trp Leu Ser Leu Ala Ser
   1               5                  10                  15    
 Gly Ala Ile Trp Ala Phe Val Ala Pro Ala Leu Phe Val Ile Val Val
              20                  25                  30        
 Asn Ile Gly Ile Leu Ile Ala Val Thr Arg Val Ile Ser Gln Ile Ser
          35                  40                  45            
 Ala Asp Asn Tyr Lys Ile His Gly Asp Pro Ser Ala Phe Lys Leu Thr
      50                  55                  60                
 Ala Lys Ala Val Ala Val Leu Leu Pro Ile Leu Gly Thr Ser Trp Val
  65                  70                  75                  80
 Phe Gly Val Leu Ala Val Asn Gly Cys Ala Val Val Phe Gln Tyr Met
                  85                  90                  95    
 Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu Phe Ile Phe Leu Phe His
             100                 105                 110        
 Cys Leu Leu Asn Ser Glu Val Arg Ala Ala Phe Lys His Lys Thr Lys
         115                 120                 125            
 Val Trp Ser Leu Thr Ser Ser Ser Ala Arg Thr Ser Asn Ala Lys Pro
     130                 135                 140                
 Phe His Ser Asp Leu Met Asn Gly Thr Arg Pro Gly Met Ala Ser Thr
 145                 150                 155                 160
 Lys Leu Ser Pro Trp Asp Lys Ser Ser His Ser Ala His Arg Val Asp
                 165                 170                 175    
 Leu Ser Ala Val
             180



      <210> 108
      <211> 374
      <212> PRT
      <213> Homo sapiens


      <400> 108
 Met Met Pro Gly Thr Ala Leu Glu Gly Val Leu Leu Ala Val Leu Leu
   1               5                  10                  15    
 Val Gly Leu Gln Thr Ala Thr Gly Arg Leu Leu Ser Gly Gln Pro Val
              20                  25                  30        
 Cys Arg Gly Gly Thr Gln Arg Pro Cys Tyr Lys Val Ile Tyr Phe His
          35                  40                  45            
 Asp Thr Ser Arg Arg Leu Asn Phe Glu Glu Ala Lys Glu Ala Cys Arg
      50                  55                  60                
 Arg Asp Gly Gly Gln Leu Val Ser Ile Glu Ser Glu Asp Glu Gln Lys
  65                  70                  75                  80
 Leu Ile Glu Lys Phe Ile Glu Asn Leu Leu Pro Ser Asp Gly Asp Phe
                  85                  90                  95    
 Trp Ile Gly Leu Arg Arg Arg Glu Glu Lys Gln Ser Asn Ser Thr Ala
             100                 105                 110        
 Cys Gln Asp Leu Tyr Ala Trp Thr Asp Gly Ser Ile Ser Gln Phe Arg
         115                 120                 125            
 Asn Trp Tyr Val Asp Glu Pro Ser Cys Gly Ser Glu Val Cys Val Val
     130                 135                 140                
 Met Tyr His Gln Pro Ser Ala Pro Ala Gly Ile Gly Gly Pro Tyr Met
 145                 150                 155                 160
 Phe Gln Trp Asn Asp Asp Arg Cys Asn Met Lys Asn Asn Phe Ile Cys
                 165                 170                 175    
 Lys Tyr Ser Asp Glu Lys Pro Ala Val Pro Ser Arg Glu Ala Glu Gly
             180                 185                 190        
 Glu Glu Thr Glu Leu Thr Thr Pro Val Leu Pro Glu Glu Thr Gln Glu
         195                 200                 205            
 Glu Asp Ala Lys Lys Thr Phe Lys Glu Ser Arg Glu Ala Ala Leu Asn
     210                 215                 220                
 Leu Ala Tyr Ile Leu Ile Pro Ser Ile Pro Leu Leu Leu Leu Leu Val
 225                 230                 235                 240
 Val Thr Thr Val Val Cys Trp Val Trp Ile Cys Arg Lys Arg Lys Arg
                 245                 250                 255    
 Glu Gln Pro Asp Pro Ser Thr Lys Lys Gln His Thr Ile Trp Pro Ser
             260                 265                 270        
 Pro His Gln Gly Asn Ser Pro Asp Leu Glu Val Tyr Asn Val Ile Arg
         275                 280                 285            
 Lys Gln Ser Glu Ala Asp Leu Ala Glu Thr Arg Pro Asp Leu Lys Asn
     290                 295                 300                
 Ile Ser Phe Arg Val Cys Ser Gly Glu Ala Thr Pro Asp Asp Met Ser
 305                 310                 315                 320
 Cys Asp Tyr Asp Asn Met Ala Val Asn Pro Ser Glu Ser Gly Phe Val
                 325                 330                 335    
 Thr Leu Val Ser Val Glu Ser Gly Phe Val Thr Asn Asp Ile Tyr Glu
             340                 345                 350        
 Phe Ser Pro Asp Gln Met Gly Arg Ser Lys Glu Ser Gly Trp Val Glu
         355                 360                 365            
 Asn Glu Ile Tyr Gly Tyr
     370                



      <210> 109
      <211> 503
      <212> PRT
      <213> Homo sapiens


      <400> 109
 Met Tyr Leu Val Ala Gly Asp Arg Gly Leu Ala Gly Cys Gly His Leu
   1               5                  10                  15    
 Leu Val Ser Leu Leu Gly Leu Leu Leu Leu Leu Ala Arg Ser Gly Thr
              20                  25                  30        
 Arg Ala Leu Val Cys Leu Pro Cys Asp Glu Ser Lys Cys Glu Glu Pro
          35                  40                  45            
 Arg Asn Cys Pro Gly Ser Ile Val Gln Gly Val Cys Gly Cys Cys Tyr
      50                  55                  60                
 Thr Cys Ala Ser Gln Arg Asn Glu Ser Cys Gly Gly Thr Phe Gly Ile
  65                  70                  75                  80
 Tyr Gly Thr Cys Asp Arg Gly Leu Arg Cys Val Ile Arg Pro Pro Leu
                  85                  90                  95    
 Asn Gly Asp Ser Leu Thr Glu Tyr Glu Ala Gly Val Cys Glu Asp Glu
             100                 105                 110        
 Asn Trp Thr Asp Asp Gln Leu Leu Gly Phe Lys Pro Cys Asn Glu Asn
         115                 120                 125            
 Leu Ile Ala Gly Cys Asn Ile Ile Asn Gly Lys Cys Glu Cys Asn Thr
     130                 135                 140                
 Ile Arg Thr Cys Ser Asn Pro Phe Glu Phe Pro Ser Gln Asp Met Cys
 145                 150                 155                 160
 Leu Ser Ala Leu Lys Arg Ile Glu Glu Glu Lys Pro Asp Cys Ser Lys
                 165                 170                 175    
 Ala Arg Cys Glu Val Gln Phe Ser Pro Arg Cys Pro Glu Asp Ser Val
             180                 185                 190        
 Leu Ile Glu Gly Tyr Ala Pro Pro Gly Glu Cys Cys Pro Leu Pro Ser
         195                 200                 205            
 Arg Cys Val Cys Asn Pro Ala Gly Cys Leu Arg Lys Val Cys Gln Pro
     210                 215                 220                
 Gly Asn Leu Asn Ile Leu Val Ser Lys Ala Ser Gly Lys Pro Gly Glu
 225                 230                 235                 240
 Cys Cys Asp Leu Tyr Glu Cys Lys Pro Val Phe Gly Val Asp Cys Arg
                 245                 250                 255    
 Thr Val Glu Cys Pro Pro Val Gln Gln Thr Ala Arg Cys Pro Pro Asp
             260                 265                 270        
 Ser Tyr Glu Thr Gln Val Arg Leu Thr Ala Asp Gly Cys Cys Pro Leu
         275                 280                 285            
 Pro Pro Arg Cys Glu Cys Leu Ser Gly Leu Cys Gly Phe Pro Val Cys
     290                 295                 300                
 Glu Val Gly Ser Thr Pro Arg Ile Val Ser Arg Gly Asp Gly Thr Pro
 305                 310                 315                 320
 Gly Lys Cys Cys Asp Val Phe Glu Cys Val Asn Asp Thr Lys Pro Ala
                 325                 330                 335    
 Cys Val Phe Asn Asn Val Glu Tyr Tyr Asp Gly Asp Met Phe Arg Met
             340                 345                 350        
 Asp Asn Cys Arg Phe Cys Arg Cys Gln Gly Gly Val Ala Ile Cys Phe
         355                 360                 365            
 Thr Ala Gln Cys Gly Glu Ile Asn Cys Glu Arg Tyr Tyr Val Pro Glu
     370                 375                 380                
 Gly Glu Cys Cys Pro Val Cys Glu Asp Pro Val Tyr Pro Phe Asn Asn
 385                 390                 395                 400
 Pro Ala Gly Cys Tyr Ala Asn Gly Leu Ile Leu Ala His Gly Asp Arg
                 405                 410                 415    
 Trp Arg Glu Asp Asp Cys Thr Phe Cys Gln Cys Val Asn Gly Glu Arg
             420                 425                 430        
 His Cys Val Ala Thr Val Cys Gly Gln Thr Cys Thr Asn Pro Val Lys
         435                 440                 445            
 Val Pro Gly Glu Cys Cys Pro Val Cys Glu Glu Pro Thr Ile Ile Thr
     450                 455                 460                
 Val Asp Pro Pro Ala Cys Gly Glu Leu Ser Asn Cys Thr Leu Thr Gly
 465                 470                 475                 480
 Lys Asp Cys Ile Asn Gly Phe Lys Arg Asp His Asn Gly Cys Arg Thr
                 485                 490                 495    
 Cys Gln Cys Ile Asn Ser Glu
             500            



      <210> 110
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 110
 Met Trp Leu Pro Pro Ala Leu Leu Leu Leu Ser Leu Ser Gly Cys Phe
   1               5                  10                  15    
 Ser Ile Gln Gly Pro Glu Ser Val Arg Ala Pro Glu Gln Gly Ser Leu
              20                  25                  30        
 Thr Val Gln Cys His Tyr Lys Gln Gly Trp Glu Thr Tyr Ile Lys Trp
          35                  40                  45            
 Trp Cys Arg Gly Val Arg Trp Asp Thr Cys Lys Ile Leu Ile Glu Thr
      50                  55                  60                
 Arg Gly Ser Glu Gln Gly Glu Lys Ser Asp Arg Val Ser Ile Lys Asp
  65                  70                  75                  80
 Asn Gln Lys Asp Arg Thr Phe Thr Val Thr Met Glu Gly Leu Arg Arg
                  85                  90                  95    
 Asp Asp Ala Asp Val Tyr Trp Cys Gly Ile Glu Arg Arg Gly Pro Asp
             100                 105                 110        
 Leu Gly Thr Gln Val Lys Val Ile Val Asp Pro
         115                 120            



      <210> 111
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 111
 Met Ser Cys Ile Leu Gly Phe Cys Phe Pro Gly Cys Phe Ser Ile Gln
   1               5                  10                  15    
 Gly Pro Glu Ser Val Arg Ala Pro Glu Gln Gly Ser Leu Thr Val Gln
              20                  25                  30        
 Cys His Tyr Lys Gln Gly Trp Glu Thr Tyr Ile Lys Trp Trp Cys Arg
          35                  40                  45            
 Gly Val Arg Trp Asp Thr Cys Lys Ile Leu Ile Glu Thr Arg Gly Ser
      50                  55                  60                
 Glu Gln Gly Glu Lys Ser Asp Arg Val Ser Ile Lys Asp Asn Gln Lys
  65                  70                  75                  80
 Asp Arg Thr Phe Thr Val Thr Met Glu Gly Leu Arg Arg Asp Asp Ala
                  85                  90                  95    
 Asp Val Tyr Trp Cys Gly Ile Glu Arg Arg Gly Pro Asp Leu Gly Thr
             100                 105                 110        
 Gln Val Lys Val Ile Val Asp Pro
         115                 120



      <210> 112
      <211> 346
      <212> PRT
      <213> Homo sapiens


      <400> 112
 Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu
   1               5                  10                  15    
 Met Glu Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr
              20                  25                  30        
 Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile
          35                  40                  45            
 Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu
      50                  55                  60                
 Gln Pro Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu
  65                  70                  75                  80
 Ala Ile Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp
                  85                  90                  95    
 Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg
             100                 105                 110        
 Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe
         115                 120                 125            
 Leu Thr Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe
     130                 135                 140                
 Arg Leu Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly
 145                 150                 155                 160
 Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser
                 165                 170                 175    
 Gly Ser Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu
             180                 185                 190        
 Tyr Lys Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val
         195                 200                 205            
 Gly Cys Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile
     210                 215                 220                
 Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val
 225                 230                 235                 240
 Ser His Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe
                 245                 250                 255    
 Phe Leu Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr
             260                 265                 270        
 Thr Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val
         275                 280                 285            
 Ile Thr Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu
     290                 295                 300                
 Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu
 305                 310                 315                 320
 Arg Lys Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val
                 325                 330                 335    
 Ser Val Trp Leu Arg Lys Glu Thr Arg Val
             340                 345    



      <210> 113
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 113
 Met Glu Thr Tyr Ala Glu Val Gly Lys Glu Gly Lys Pro Ser Cys Ala
   1               5                  10                  15    
 Ser Val Asp Leu Gln Gly Asp Ser Ser Leu Gln Val Glu Ile Ser Asp
              20                  25                  30        
 Ala Val Ser Glu Arg Asp Lys Val Lys Phe Thr Val Gln Thr Lys Ser
          35                  40                  45            
 Cys Leu Pro His Phe Ala Gln Thr Glu Phe Ser Val Val Arg Gln His
      50                  55                  60                
 Glu Glu Phe Ile Trp Leu His Asp Ala Tyr Val Glu Asn Glu Glu Tyr
  65                  70                  75                  80
 Ala Gly Leu Ile Ile Pro Pro Ala Pro Pro Arg Pro Asp Phe Glu Ala
                  85                  90                  95    
 Ser Arg Glu Lys Leu Gln Lys Leu Gly Glu Gly Asp Ser Ser Val Thr
             100                 105                 110        
 Arg Glu Glu Phe Ala Lys Met Lys Gln Glu Leu Glu Ala Glu Tyr Leu
         115                 120                 125            
 Ala Ile Phe Lys Lys Thr Val Ala Met His Glu Val Phe Leu Gln Arg
     130                 135                 140                
 Leu Ala Ala His Pro Thr Leu Arg Arg Asp His Asn Phe Phe Val Phe
 145                 150                 155                 160
 Leu Glu Tyr Gly Gln Asp Leu Ser Val Arg Gly Lys Asn Arg Lys Glu
                 165                 170                 175    
 Leu Leu Gly Gly Phe Leu Arg Asn Ile Val Lys Ser Ala Asp Glu Ala
             180                 185                 190        
 Leu Ile Thr Gly Met Ser Gly Leu Lys Glu Val Asp Asp Phe Phe Glu
         195                 200                 205            
 His Glu Arg Thr Phe Leu Leu Glu Tyr His Thr Arg Ile Arg Asp Ala
     210                 215                 220                
 Cys Leu Arg Ala Asp Arg Val Met Arg Ala His Lys Cys Leu Ala Asp
 225                 230                 235                 240
 Asp Tyr Ile Pro Ile Ser Ala Ala Leu Ser Ser Leu Gly Thr Gln Glu
                 245                 250                 255    
 Val Asn Gln Leu Arg Thr Ser Phe Leu Lys Leu Ala Glu Leu Phe Glu
             260                 265                 270        
 Arg Leu Arg Lys Leu Glu Gly Arg Val Ala Ser Asp Glu Asp Leu Lys
         275                 280                 285            
 Leu Ser Asp Met Leu Arg Tyr Tyr Met Arg Asp Ser Gln Ala Ala Lys
     290                 295                 300                
 Asp Leu Leu Tyr Arg Arg Leu Arg Ala Leu Ala Asp Tyr Glu Asn Ala
 305                 310                 315                 320
 Asn Lys Ala Leu Asp Lys Ala Arg Thr Arg Asn Arg Glu Val Arg Pro
                 325                 330                 335    
 Ala Glu Ser His Gln Gln Leu Cys Cys Gln Arg Phe Glu Arg Leu Ser
             340                 345                 350        
 Asp Ser Ala Lys Gln Glu Leu Met Asp Phe Lys Ser Arg Arg Val Ser
         355                 360                 365            
 Ser Phe Arg Lys Asn Leu Ile Glu Leu Ala Glu Leu Glu Leu Lys His
     370                 375                 380                
 Ala Lys Ala Ser Thr Leu Ile Leu Arg Asn Thr Leu Val Ala Leu Lys
 385                 390                 395                 400
 Gly Glu Pro
            



      <210> 114
      <211> 806
      <212> PRT
      <213> Homo sapiens


      <400> 114
 Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val
   1               5                  10                  15    
 Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met
              20                  25                  30        
 Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg
          35                  40                  45            
 Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser
      50                  55                  60                
 Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala
  65                  70                  75                  80
 Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala
                  85                  90                  95    
 Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly
             100                 105                 110        
 Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala
         115                 120                 125            
 Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser
     130                 135                 140                
 Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Val Gln Thr Cys Leu
 145                 150                 155                 160
 Glu Pro Gly Gly Arg Gly Pro Ser Gly Glu Arg Ser Val Ala Gly Asp
                 165                 170                 175    
 Leu Arg Ser Leu Gly Asp Arg Gly Ser Val Arg Arg Glu Gly Lys Val
             180                 185                 190        
 Ala Ser Trp Leu Gly Ser Ser Pro Arg Ser Arg Gly Glu Leu Leu Pro
         195                 200                 205            
 Gly Arg Arg Pro Ser Ser Pro Ser Ser His Gly Gln Met Leu Thr Pro
     210                 215                 220                
 Lys Ile Asn Lys Leu Glu Lys Ala Val Ala Ala Ala His Thr Phe Phe
 225                 230                 235                 240
 Val Gly Asn Pro Glu His Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr
                 245                 250                 255    
 Gln Thr Met Ser Gly Val Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr
             260                 265                 270        
 Gln Pro His Met Gln Glu Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu
         275                 280                 285            
 Glu Gln Pro Gln Glu Ala Val Pro His Leu Glu Ala Ala Leu Gln Glu
     290                 295                 300                
 Tyr Phe Val Ala Tyr Glu Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr
 305                 310                 315                 320
 Asp Tyr Asp Gly Tyr Asn Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln
                 325                 330                 335    
 Ala Ile Thr Asp His Tyr Ile Gln Val Leu Asn Cys Lys Gln Asn Cys
             340                 345                 350        
 Val Thr Glu Leu Ala Ser His Pro Ser Arg Glu Lys Pro Phe Glu Asp
         355                 360                 365            
 Phe Leu Pro Ser His Tyr Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile
     370                 375                 380                
 Gly Asn Tyr Thr Gln Ala Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe
 385                 390                 395                 400
 Phe Pro Asn Asp Glu Val Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala
                 405                 410                 415    
 Met Leu Gly Glu Glu His Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala
             420                 425                 430        
 Lys Glu Tyr Arg Gln Arg Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe
         435                 440                 445            
 Ala Tyr Asp Val Phe Gly Ile Pro Phe Val Asp Pro Asp Ser Trp Thr
     450                 455                 460                
 Pro Glu Glu Val Ile Pro Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu
 465                 470                 475                 480
 Arg Glu Thr Ala Val Arg Ile Ser Gln Glu Ile Gly Asn Leu Met Lys
                 485                 490                 495    
 Glu Ile Glu Thr Leu Val Glu Glu Lys Thr Lys Glu Ser Leu Asp Val
             500                 505                 510        
 Ser Arg Leu Thr Arg Glu Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser
         515                 520                 525            
 Leu Thr Met Asn Ser Lys Leu Leu Asn Gly Ser Gln Arg Val Val Met
     530                 535                 540                
 Asp Gly Val Ile Ser Asp His Glu Cys Gln Glu Leu Gln Arg Leu Thr
 545                 550                 555                 560
 Asn Val Ala Ala Thr Ser Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro
                 565                 570                 575    
 His Thr Pro Asn Glu Lys Phe Tyr Gly Val Thr Val Phe Lys Ala Leu
             580                 585                 590        
 Lys Leu Gly Gln Glu Gly Lys Val Pro Leu Gln Ser Ala His Leu Tyr
         595                 600                 605            
 Tyr Asn Val Thr Glu Lys Val Arg Arg Ile Met Glu Ser Tyr Phe Arg
     610                 615                 620                
 Leu Asp Thr Pro Leu Tyr Phe Ser Tyr Ser His Leu Val Cys Arg Thr
 625                 630                 635                 640
 Ala Ile Glu Glu Val Gln Ala Glu Arg Lys Asp Asp Ser His Pro Val
                 645                 650                 655    
 His Val Asp Asn Cys Ile Leu Asn Ala Glu Thr Leu Val Cys Val Lys
             660                 665                 670        
 Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu
         675                 680                 685            
 Asn Gly Asp Phe Asp Gly Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala
     690                 695                 700                
 Lys Thr Val Thr Ala Glu Val Gln Pro Gln Cys Gly Arg Ala Val Gly
 705                 710                 715                 720
 Phe Ser Ser Gly Thr Glu Asn Pro His Gly Val Lys Ala Val Thr Arg
                 725                 730                 735    
 Gly Gln Arg Cys Ala Ile Ala Leu Trp Phe Thr Leu Asp Pro Arg His
             740                 745                 750        
 Ser Glu Arg Asp Arg Val Gln Ala Asp Asp Leu Val Lys Met Leu Phe
         755                 760                 765            
 Ser Pro Glu Glu Met Asp Leu Ser Gln Glu Gln Pro Leu Asp Ala Gln
     770                 775                 780                
 Gln Gly Pro Pro Glu Pro Ala Gln Glu Ser Leu Ser Gly Ser Glu Ser
 785                 790                 795                 800
 Lys Pro Lys Asp Glu Leu
                 805    



      <210> 115
      <211> 906
      <212> PRT
      <213> Homo sapiens


      <400> 115
 Met Ala Leu Glu Gln Ala Leu Gln Ala Ala Arg Gln Gly Glu Leu Asp
   1               5                  10                  15    
 Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg
              20                  25                  30        
 Asp Pro Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ala Gly Lys
          35                  40                  45            
 Leu His Cys Leu Arg Phe Leu Val Glu Glu Ala Ala Leu Pro Ala Ala
      50                  55                  60                
 Ala Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ser Ala Thr
  65                  70                  75                  80
 Gly His Leu Ala Cys Leu Gln Trp Leu Leu Ser Gln Gly Gly Cys Arg
                  85                  90                  95    
 Val Gln Ala Phe Pro Glu Ser Leu Gly Val Arg Ala Val Ala Leu Gly
             100                 105                 110        
 Leu Val Pro Val Ser Cys Arg Asp Asn Gln Asp Lys Asp Asn Ser Gly
         115                 120                 125            
 Ala Thr Val Leu His Leu Ala Ala Arg Phe Gly His Pro Glu Val Val
     130                 135                 140                
 Asn Trp Leu Leu His His Gly Gly Gly Asp Pro Thr Ala Ala Thr Asp
 145                 150                 155                 160
 Met Gly Ala Leu Pro Ile His Tyr Ala Ala Ala Lys Gly Asp Phe Pro
                 165                 170                 175    
 Ser Leu Arg Leu Leu Val Glu His Tyr Pro Glu Gly Val Asn Ala Gln
             180                 185                 190        
 Thr Lys Asn Gly Ala Thr Pro Leu Tyr Leu Ala Cys Gln Glu Gly His
         195                 200                 205            
 Leu Glu Val Thr Gln Tyr Leu Val Gln Glu Cys Gly Ala Asp Pro His
     210                 215                 220                
 Ala Arg Ala His Asp Gly Met Thr Pro Leu His Ala Ala Ala Gln Met
 225                 230                 235                 240
 Gly His Ser Pro Val Ile Val Trp Leu Val Ser Cys Thr Asp Val Ser
                 245                 250                 255    
 Leu Ser Glu Gln Asp Lys Asp Gly Ala Thr Ala Met His Phe Ala Ala
             260                 265                 270        
 Ser Arg Gly His Thr Lys Val Leu Ser Trp Leu Leu Leu His Gly Gly
         275                 280                 285            
 Glu Ile Ser Ala Asp Leu Trp Gly Gly Thr Pro Leu His Asp Ala Ala
     290                 295                 300                
 Glu Asn Gly Glu Leu Glu Cys Cys Gln Ile Leu Val Val Asn Gly Ala
 305                 310                 315                 320
 Glu Leu Asp Val Arg Asp Arg Asp Gly Tyr Thr Ala Ala Asp Leu Ser
                 325                 330                 335    
 Asp Phe Asn Gly His Ser His Cys Thr Arg Tyr Leu Arg Thr Val Glu
             340                 345                 350        
 Asn Leu His Arg Gly Met Val Leu Ala Leu Gly Ala Ala Glu His Ser
         355                 360                 365            
 Lys Ala Gln Arg Pro Glu Ala Ala Gly Gly Pro Glu Asp Glu Leu Pro
     370                 375                 380                
 Pro Ala Lys Glu Ser Leu Glu Glu Asn Glu Trp Pro Ser Arg Gly Gln
 385                 390                 395                 400
 Gly Leu Val Pro Ser Ala Pro Thr Ala Val Gly Gln Ser Val Glu His
                 405                 410                 415    
 Arg Val Leu Ser Arg Asp Pro Ser Ala Glu Leu Glu Ala Lys Gln Pro
             420                 425                 430        
 Asp Ser Gly Met Ser Ser Pro Asn Thr Thr Val Ser Val Gln Pro Leu
         435                 440                 445            
 Asn Phe Asp Leu Ser Ser Pro Thr Ser Thr Leu Ser Asn Tyr Asp Ser
     450                 455                 460                
 Cys Ser Ser Ser His Ser Ser Ile Lys Gly Gln His Pro Pro Cys Gly
 465                 470                 475                 480
 Leu Ser Ser Ala Arg Ala Ala Asp Ile Gln Ser Tyr Met Asp Met Leu
                 485                 490                 495    
 Asn Pro Glu Leu Gly Leu Pro Arg Gly Thr Ile Gly Lys Pro Thr Pro
             500                 505                 510        
 Pro Pro Pro Pro Pro Ser Phe Pro Pro Pro Pro Pro Pro Pro Gly Thr
         515                 520                 525            
 Gln Leu Pro Pro Pro Pro Pro Gly Tyr Pro Ala Pro Lys Pro Pro Val
     530                 535                 540                
 Gly Pro Gln Ala Ala Asp Ile Tyr Met Gln Thr Lys Asn Lys Leu Arg
 545                 550                 555                 560
 His Val Glu Thr Glu Ala Leu Lys Lys Glu Leu Ser Ser Cys Asp Gly
                 565                 570                 575    
 His Asp Gly Leu Arg Arg Gln Asp Ser Ser Arg Lys Pro Arg Ala Phe
             580                 585                 590        
 Ser Lys Gln Pro Ser Thr Gly Asp Tyr Tyr Arg Gln Leu Gly Arg Cys
         595                 600                 605            
 Pro Gly Glu Thr Leu Ala Ala Arg Pro Gly Met Ala His Ser Glu Glu
     610                 615                 620                
 Ala Ala Leu Leu Pro Gly Asn His Val Pro Asn Gly Cys Ala Ala Asp
 625                 630                 635                 640
 Pro Lys Ala Ser Arg Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro
                 645                 650                 655    
 Pro Leu Pro Glu Ala Ala Ser Ser Pro Pro Pro Ala Pro Pro Leu Pro
             660                 665                 670        
 Leu Glu Ser Ala Gly Pro Gly Cys Gly Gln Arg Arg Ser Ser Ser Ser
         675                 680                 685            
 Thr Gly Ser Thr Lys Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn
     690                 695                 700                
 Ser Glu Leu Leu Ala Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr
 705                 710                 715                 720
 Pro Gln Ser Lys Gly Leu Thr Thr Val Phe Ser Gly Ile Gly Gln Pro
                 725                 730                 735    
 Ala Phe Gln Pro Asp Ser Pro Leu Pro Ser Val Ser Pro Ala Leu Ser
             740                 745                 750        
 Pro Val Arg Ser Pro Thr Pro Pro Ala Ala Gly Phe Gln Pro Leu Leu
         755                 760                 765            
 Asn Gly Ser Leu Val Pro Val Pro Pro Thr Thr Pro Ala Pro Gly Val
     770                 775                 780                
 Gln Leu Asp Val Glu Ala Leu Ile Pro Thr His Asp Glu Gln Gly Arg
 785                 790                 795                 800
 Pro Ile Pro Glu Trp Lys Arg Gln Val Met Val Arg Lys Met Gln Leu
                 805                 810                 815    
 Lys Met Gln Glu Glu Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu
             820                 825                 830        
 Ala Arg Leu Ala Ser Met Pro Ala Trp Arg Arg Asp Leu Leu Arg Lys
         835                 840                 845            
 Lys Leu Glu Glu Glu Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln
     850                 855                 860                
 Lys Gln Glu Glu Leu Arg Arg Glu Lys Glu Gln Ser Glu Lys Leu Arg
 865                 870                 875                 880
 Thr Leu Gly Tyr Asp Glu Ser Lys Leu Ala Pro Trp Gln Arg Gln Val
                 885                 890                 895    
 Ile Leu Lys Lys Gly Asp Ile Ala Lys Tyr
             900                 905    



      <210> 116
      <211> 848
      <212> PRT
      <213> Homo sapiens


      <400> 116
 Met Ala Leu Glu Gln Ala Leu Gln Ala Ala Arg Gln Gly Glu Leu Asp
   1               5                  10                  15    
 Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg
              20                  25                  30        
 Asp Pro Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ala Gly Lys
          35                  40                  45            
 Leu His Cys Leu Arg Phe Leu Val Glu Glu Ala Ala Leu Pro Ala Ala
      50                  55                  60                
 Ala Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ser Ala Thr
  65                  70                  75                  80
 Gly His Leu Ala Cys Leu Gln Trp Leu Leu Ser Gln Gly Gly Cys Arg
                  85                  90                  95    
 Val Gln Ala Phe Pro Glu Ser Leu Gly Val Arg Ala Val Ala Leu Gly
             100                 105                 110        
 Leu Val Pro Val Ser Cys Arg Asp Asn Gln Asp Lys Asp Asn Ser Gly
         115                 120                 125            
 Ala Thr Val Leu His Leu Ala Ala Arg Phe Gly His Pro Glu Val Val
     130                 135                 140                
 Asn Trp Leu Leu His His Gly Gly Gly Asp Pro Thr Ala Ala Thr Asp
 145                 150                 155                 160
 Met Gly Ala Leu Pro Ile His Tyr Ala Ala Ala Lys Gly Asp Phe Pro
                 165                 170                 175    
 Ser Leu Arg Leu Leu Val Glu His Tyr Pro Glu Gly Val Asn Ala Gln
             180                 185                 190        
 Thr Lys Asn Gly Ala Thr Pro Leu Tyr Leu Ala Cys Gln Glu Gly His
         195                 200                 205            
 Leu Glu Val Thr Gln Tyr Leu Val Gln Glu Cys Gly Ala Asp Pro His
     210                 215                 220                
 Ala Arg Ala His Asp Gly Met Thr Pro Leu His Ala Ala Ala Gln Met
 225                 230                 235                 240
 Gly His Ser Pro Val Ile Val Trp Leu Val Ser Cys Thr Asp Val Ser
                 245                 250                 255    
 Leu Ser Glu Gln Asp Lys Asp Gly Ala Thr Ala Met His Phe Ala Ala
             260                 265                 270        
 Ser Arg Gly His Thr Lys Val Leu Ser Trp Leu Leu Leu His Gly Gly
         275                 280                 285            
 Glu Ile Ser Ala Asp Leu Trp Gly Gly Thr Pro Leu His Asp Ala Ala
     290                 295                 300                
 Glu Asn Gly Glu Leu Glu Cys Cys Gln Ile Leu Val Val Asn Gly Ala
 305                 310                 315                 320
 Glu Leu Asp Val Arg Asp Arg Asp Gly Tyr Thr Ala Ala Asp Leu Ser
                 325                 330                 335    
 Asp Phe Asn Gly His Ser His Cys Thr Arg Tyr Leu Arg Thr Val Glu
             340                 345                 350        
 Asn Leu Ser Val Glu His Arg Val Leu Ser Arg Asp Pro Ser Ala Glu
         355                 360                 365            
 Leu Glu Ala Lys Gln Pro Asp Ser Gly Met Ser Ser Pro Asn Thr Thr
     370                 375                 380                
 Val Ser Val Gln Pro Leu Asn Phe Asp Leu Ser Ser Pro Thr Ser Thr
 385                 390                 395                 400
 Leu Ser Asn Tyr Asp Ser Cys Ser Ser Ser His Ser Ser Ile Lys Gly
                 405                 410                 415    
 Gln His Pro Pro Cys Gly Leu Ser Ser Ala Arg Ala Ala Asp Ile Gln
             420                 425                 430        
 Ser Tyr Met Asp Met Leu Asn Pro Glu Leu Gly Leu Pro Arg Gly Thr
         435                 440                 445            
 Ile Gly Lys Pro Thr Pro Pro Pro Pro Pro Pro Ser Phe Pro Pro Pro
     450                 455                 460                
 Pro Pro Pro Pro Gly Thr Gln Leu Pro Pro Pro Pro Pro Gly Tyr Pro
 465                 470                 475                 480
 Ala Pro Lys Pro Pro Val Gly Pro Gln Ala Ala Asp Ile Tyr Met Gln
                 485                 490                 495    
 Thr Lys Asn Lys Leu Arg His Val Glu Thr Glu Ala Leu Lys Lys Glu
             500                 505                 510        
 Leu Ser Ser Cys Asp Gly His Asp Gly Leu Arg Arg Gln Asp Ser Ser
         515                 520                 525            
 Arg Lys Pro Arg Ala Phe Ser Lys Gln Pro Ser Thr Gly Asp Tyr Tyr
     530                 535                 540                
 Arg Gln Leu Gly Arg Cys Pro Gly Glu Thr Leu Ala Ala Arg Pro Gly
 545                 550                 555                 560
 Met Ala His Ser Glu Glu Ala Ala Leu Leu Pro Gly Asn His Val Pro
                 565                 570                 575    
 Asn Gly Cys Ala Ala Asp Pro Lys Ala Ser Arg Glu Leu Pro Pro Pro
             580                 585                 590        
 Pro Pro Pro Pro Pro Pro Pro Leu Pro Glu Ala Ala Ser Ser Pro Pro
         595                 600                 605            
 Pro Ala Pro Pro Leu Pro Leu Glu Ser Ala Gly Pro Gly Cys Gly Gln
     610                 615                 620                
 Arg Arg Ser Ser Ser Ser Thr Gly Ser Thr Lys Ser Phe Asn Met Met
 625                 630                 635                 640
 Ser Pro Thr Gly Asp Asn Ser Glu Leu Leu Ala Glu Ile Lys Ala Gly
                 645                 650                 655    
 Lys Ser Leu Lys Pro Thr Pro Gln Ser Lys Gly Leu Thr Thr Val Phe
             660                 665                 670        
 Ser Gly Ile Gly Gln Pro Ala Phe Gln Pro Asp Ser Pro Leu Pro Ser
         675                 680                 685            
 Val Ser Pro Ala Leu Ser Pro Val Arg Ser Pro Thr Pro Pro Ala Ala
     690                 695                 700                
 Gly Phe Gln Pro Leu Leu Asn Gly Ser Leu Val Pro Val Pro Pro Thr
 705                 710                 715                 720
 Thr Pro Ala Pro Gly Val Gln Leu Asp Val Glu Ala Leu Ile Pro Thr
                 725                 730                 735    
 His Asp Glu Gln Gly Arg Pro Ile Pro Glu Trp Lys Arg Gln Val Met
             740                 745                 750        
 Val Arg Lys Met Gln Leu Lys Met Gln Glu Glu Glu Glu Gln Arg Arg
         755                 760                 765            
 Lys Glu Glu Glu Glu Glu Ala Arg Leu Ala Ser Met Pro Ala Trp Arg
     770                 775                 780                
 Arg Asp Leu Leu Arg Lys Lys Leu Glu Glu Glu Arg Glu Gln Lys Arg
 785                 790                 795                 800
 Lys Glu Glu Glu Arg Gln Lys Gln Glu Glu Leu Arg Arg Glu Lys Glu
                 805                 810                 815    
 Gln Ser Glu Lys Leu Arg Thr Leu Gly Tyr Asp Glu Ser Lys Leu Ala
             820                 825                 830        
 Pro Trp Gln Arg Gln Val Ile Leu Lys Lys Gly Asp Ile Ala Lys Tyr
         835                 840                 845            





      <210> 117
      <211> 588
      <212> PRT
      <213> Homo sapiens


      <400> 117
 Met Leu Arg Leu Gln Ala Pro Gly Pro Ala Gly Arg Pro Arg Cys Phe
   1               5                  10                  15    
 Pro Leu Arg Ala Ala Arg Leu Phe Thr Arg Phe Ala Glu Ala Gly Arg
              20                  25                  30        
 Ser Thr Leu Arg Leu Pro Ala His Asp Thr Pro Gly Ala Gly Ala Val
          35                  40                  45            
 Gln Leu Leu Leu Ser Asp Cys Pro Pro Asp Arg Leu Arg Arg Phe Leu
      50                  55                  60                
 Arg Thr Leu Arg Leu Lys Leu Ala Ala Ala Pro Gly Pro Gly Pro Ala
  65                  70                  75                  80
 Ser Ala Arg Ala Gln Leu Leu Gly Pro Arg Pro Arg Asp Phe Val Thr
                  85                  90                  95    
 Ile Ser Pro Val Gln Pro Glu Glu Arg Arg Leu Arg Ala Ala Thr Arg
             100                 105                 110        
 Val Pro Asp Thr Thr Leu Val Lys Arg Pro Val Glu Pro Gln Ala Gly
         115                 120                 125            
 Ala Glu Pro Ser Thr Glu Ala Pro Arg Trp Pro Leu Pro Val Lys Arg
     130                 135                 140                
 Leu Ser Leu Pro Ser Thr Lys Pro Gln Leu Ser Glu Glu Gln Ala Ala
 145                 150                 155                 160
 Val Leu Arg Ala Ala Leu Lys Gly Gln Ser Ile Phe Phe Thr Gly Ser
                 165                 170                 175    
 Ala Gly Thr Gly Lys Ser Tyr Leu Leu Lys Arg Ile Leu Gly Ser Leu
             180                 185                 190        
 Pro Pro Thr Gly Thr Glu Ala Thr Ala Ser Thr Gly Val Ala Ala Cys
         195                 200                 205            
 His Ile Gly Gly Thr Thr Leu His Ala Phe Ala Gly Ile Gly Ser Gly
     210                 215                 220                
 Gln Ala Pro Leu Ala Gln Cys Val Ala Leu Ala Gln Arg Pro Gly Val
 225                 230                 235                 240
 Arg Gln Gly Trp Leu Asn Cys Gln Arg Leu Val Ile Asp Glu Ile Ser
                 245                 250                 255    
 Met Val Glu Ala Asp Leu Phe Asp Lys Leu Glu Ala Val Ala Arg Ala
             260                 265                 270        
 Val Arg Gln Gln Asn Lys Pro Phe Gly Gly Ile Gln Leu Ile Ile Cys
         275                 280                 285            
 Gly Asp Phe Leu Gln Leu Pro Pro Val Thr Lys Gly Ser Gln Pro Pro
     290                 295                 300                
 Arg Phe Cys Phe Gln Ser Lys Ser Trp Lys Arg Gly Val Pro Val Thr
 305                 310                 315                 320
 Leu Glu Leu Thr Lys Gly Gly Arg Gln Ala Asn Gln Thr Phe Phe Phe
                 325                 330                 335    
 Leu Leu Gln Ala Val Arg Leu Gly Arg Cys Ser Asp Glu Val Thr Arg
             340                 345                 350        
 Gln Leu Gln Ala Thr Ala Ser His Lys Val Gly Arg Asp Gly Ile Val
         355                 360                 365            
 Ala Thr Arg Leu Cys Thr His Gln Asp Asp Val Ala Leu Thr Asn Glu
     370                 375                 380                
 Arg Arg Leu Gln Glu Leu Pro Gly Lys Val His Arg Phe Glu Ala Met
 385                 390                 395                 400
 Asp Ser Asn Pro Glu Leu Ala Ser Thr Leu Asp Ala Gln Cys Pro Val
                 405                 410                 415    
 Ser Gln Leu Leu Gln Leu Lys Leu Gly Ala Gln Val Met Leu Val Lys
             420                 425                 430        
 Asn Leu Ser Val Ser Arg Gly Leu Val Asn Gly Ala Arg Gly Val Val
         435                 440                 445            
 Val Gly Phe Glu Ala Glu Gly Arg Gly Leu Pro Gln Val Arg Phe Leu
     450                 455                 460                
 Cys Gly Val Thr Glu Val Ile His Ala Asp Arg Trp Thr Val Gln Ala
 465                 470                 475                 480
 Thr Gly Gly Gln Leu Leu Ser Arg Gln Gln Leu Pro Leu Gln Leu Ala
                 485                 490                 495    
 Trp Ala Met Ser Ile His Lys Ser Gln Gly Met Thr Leu Asp Cys Val
             500                 505                 510        
 Glu Ile Ser Leu Gly Arg Val Phe Ala Ser Gly Gln Ala Tyr Val Ala
         515                 520                 525            
 Leu Ser Arg Ala Arg Ser Leu Gln Gly Leu Arg Val Leu Asp Phe Asp
     530                 535                 540                
 Pro Met Ala Val Arg Cys Asp Pro Arg Val Leu His Phe Tyr Ala Thr
 545                 550                 555                 560
 Leu Arg Arg Gly Arg Ser Leu Ser Leu Glu Ser Pro Asp Asp Asp Glu
                 565                 570                 575    
 Ala Ala Ser Asp Gln Glu Asn Met Asp Pro Ile Leu
             580                 585            



      <210> 118
      <211> 526
      <212> PRT
      <213> Homo sapiens


      <400> 118
 Met Leu Arg Leu Gln Ala Pro Gly Pro Ala Gly Arg Pro Arg Cys Phe
   1               5                  10                  15    
 Pro Leu Arg Ala Ala Arg Leu Phe Thr Arg Phe Ala Glu Ala Gly Arg
              20                  25                  30        
 Ser Thr Leu Arg Leu Pro Ala His Asp Thr Pro Gly Ala Gly Ala Val
          35                  40                  45            
 Gln Leu Leu Leu Ser Asp Cys Pro Pro Asp Arg Leu Arg Arg Phe Leu
      50                  55                  60                
 Arg Thr Leu Arg Leu Lys Leu Ala Ala Ala Pro Gly Pro Gly Pro Ala
  65                  70                  75                  80
 Ser Ala Arg Ala Gln Leu Leu Gly Pro Arg Pro Arg Asp Phe Val Thr
                  85                  90                  95    
 Ile Ser Pro Val Gln Pro Glu Glu Arg Arg Leu Arg Ala Ala Thr Arg
             100                 105                 110        
 Val Pro Asp Thr Thr Leu Val Lys Arg Pro Val Glu Pro Gln Ala Gly
         115                 120                 125            
 Ala Glu Pro Ser Thr Glu Ala Pro Arg Trp Pro Leu Pro Val Lys Arg
     130                 135                 140                
 Leu Ser Leu Pro Ser Thr Lys Pro Gln Leu Ser Glu Glu Gln Ala Ala
 145                 150                 155                 160
 Val Leu Arg Ala Ala Leu Lys Gly Gln Ser Ile Phe Phe Thr Gly Ser
                 165                 170                 175    
 Ala Gly Thr Gly Lys Ser Tyr Leu Leu Lys Arg Ile Leu Gly Ser Leu
             180                 185                 190        
 Pro Pro Thr Gly Thr Glu Ala Thr Ala Ser Thr Gly Val Ala Ala Cys
         195                 200                 205            
 His Ile Gly Gly Thr Thr Leu His Ala Phe Ala Gly Ile Gly Ser Gly
     210                 215                 220                
 Gln Ala Pro Leu Ala Gln Cys Val Ala Leu Ala Gln Arg Pro Gly Val
 225                 230                 235                 240
 Arg Gln Gly Trp Leu Asn Cys Gln Arg Leu Val Ile Asp Glu Ile Ser
                 245                 250                 255    
 Met Val Glu Ala Asp Leu Phe Asp Lys Leu Glu Ala Val Ala Arg Ala
             260                 265                 270        
 Val Arg Gln Gln Asn Lys Pro Phe Gly Gly Ile Gln Leu Ile Ile Cys
         275                 280                 285            
 Gly Asp Phe Leu Gln Leu Pro Pro Val Thr Lys Gly Ser Gln Pro Pro
     290                 295                 300                
 Arg Phe Cys Phe Gln Ser Ser Pro Asn Arg Cys Ser Asp Glu Val Thr
 305                 310                 315                 320
 Arg Gln Leu Gln Ala Thr Ala Ser His Lys Val Gly Arg Asp Gly Ile
                 325                 330                 335    
 Val Ala Thr Arg Leu Cys Thr His Gln Asp Asp Val Ala Leu Thr Asn
             340                 345                 350        
 Glu Arg Arg Leu Gln Glu Leu Pro Gly Lys Val His Arg Phe Glu Ala
         355                 360                 365            
 Met Asp Ser Asn Pro Glu Leu Ala Ser Thr Leu Asp Ala Gln Cys Pro
     370                 375                 380                
 Val Ser Gln Leu Leu Gln Leu Lys Leu Gly Ala Gln Val Met Leu Val
 385                 390                 395                 400
 Lys Asn Leu Ser Val Ser Arg Gly Leu Val Asn Gly Ala Arg Gly Val
                 405                 410                 415    
 Val Val Gly Phe Glu Ala Glu Gly Arg Gly Leu Pro Gln Val Arg Phe
             420                 425                 430        
 Leu Cys Gly Val Thr Glu Val Ile His Ala Asp Arg Trp Thr Val Gln
         435                 440                 445            
 Ala Thr Gly Gly Gln Leu Leu Ser Arg Gln Gln Leu Pro Leu Gln Leu
     450                 455                 460                
 Ala Trp Ala Met Ser Ile His Lys Ser Gln Gly Leu Arg Val Leu Asp
 465                 470                 475                 480
 Phe Asp Pro Met Ala Val Arg Cys Asp Pro Arg Val Leu His Phe Tyr
                 485                 490                 495    
 Ala Thr Leu Arg Arg Gly Arg Ser Leu Ser Leu Glu Ser Pro Asp Asp
             500                 505                 510        
 Asp Glu Ala Ala Ser Asp Gln Glu Asn Met Asp Pro Ile Leu
         515                 520                 525    



      <210> 119
      <211> 674
      <212> PRT
      <213> Homo sapiens


      <400> 119
 Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys
   1               5                  10                  15    
 Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp
              20                  25                  30        
 Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser
          35                  40                  45            
 Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu
      50                  55                  60                
 Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn
  65                  70                  75                  80
 Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp
                  85                  90                  95    
 Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met
             100                 105                 110        
 Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser
         115                 120                 125            
 Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr
     130                 135                 140                
 Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser
 145                 150                 155                 160
 Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe
                 165                 170                 175    
 Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met
             180                 185                 190        
 Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly
         195                 200                 205            
 Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val
     210                 215                 220                
 Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val
 225                 230                 235                 240
 Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln
                 245                 250                 255    
 Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro
             260                 265                 270        
 Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu
         275                 280                 285            
 Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val
     290                 295                 300                
 Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser
 305                 310                 315                 320
 Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile
                 325                 330                 335    
 Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln
             340                 345                 350        
 Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro
         355                 360                 365            
 Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile
     370                 375                 380                
 Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp
 385                 390                 395                 400
 Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile
                 405                 410                 415    
 Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly
             420                 425                 430        
 Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr
         435                 440                 445            
 Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser
     450                 455                 460                
 Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys
 465                 470                 475                 480
 Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val
                 485                 490                 495    
 Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly
             500                 505                 510        
 Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu
         515                 520                 525            
 Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala
     530                 535                 540                
 Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val
 545                 550                 555                 560
 Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile
                 565                 570                 575    
 Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu
             580                 585                 590        
 Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met
         595                 600                 605            
 Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln
     610                 615                 620                
 Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala
 625                 630                 635                 640
 Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser
                 645                 650                 655    
 Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys
             660                 665                 670        
 Gly Lys
        



      <210> 120
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 120
 Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
   1               5                  10                  15    
 Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp
              20                  25                  30        
 Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg
          35                  40                  45            
 Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly
      50                  55                  60                
 Glu Tyr Ser Gln Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
  65                  70                  75                  80
 Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                  85                  90                  95    
 Tyr Gln Lys His Arg Lys Gly Lys Gln Phe Gln Glu Arg Leu Leu Leu
             100                 105                 110        
 Glu Ile Pro Thr Ser Val Asp Trp Arg Glu Lys Gly Tyr Met Thr Pro
         115                 120                 125            
 Val Lys Asp Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
     130                 135                 140                
 Gly Ala Leu Glu Gly Gln Met Phe Trp Lys Thr Gly Lys Leu Ile Ser
 145                 150                 155                 160
 Leu Asn Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                 165                 170                 175    
 Gly Cys Asn Gly Asp Phe Met Asp Asn Pro Phe Arg Tyr Val Gln Glu
             180                 185                 190        
 Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
         195                 200                 205            
 Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
     210                 215                 220                
 Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
 225                 230                 235                 240
 Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                 245                 250                 255    
 Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
             260                 265                 270        
 Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
         275                 280                 285            
 Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
     290                 295                 300                
 Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
 305                 310                 315                 320
 His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                 325                 330            



      <210> 121
      <211> 794
      <212> PRT
      <213> Homo sapiens


      <400> 121
 Met Leu Cys Gly Arg Trp Arg Arg Cys Arg Arg Pro Pro Glu Glu Pro
   1               5                  10                  15    
 Pro Val Ala Ala Gln Val Ala Ala Gln Val Ala Ala Pro Val Ala Leu
              20                  25                  30        
 Pro Ser Pro Pro Thr Pro Ser Asp Gly Gly Thr Lys Arg Pro Gly Leu
          35                  40                  45            
 Arg Ala Leu Lys Lys Met Gly Leu Thr Glu Asp Glu Asp Val Arg Ala
      50                  55                  60                
 Met Leu Arg Gly Ser Arg Leu Arg Lys Ile Arg Ser Arg Thr Trp His
  65                  70                  75                  80
 Lys Glu Arg Leu Tyr Arg Leu Gln Glu Asp Gly Leu Ser Val Trp Phe
                  85                  90                  95    
 Gln Arg Arg Ile Pro Arg Ala Pro Ser Gln His Ile Phe Phe Val Gln
             100                 105                 110        
 His Ile Glu Ala Val Arg Glu Gly His Gln Ser Glu Gly Leu Arg Arg
         115                 120                 125            
 Phe Gly Gly Ala Phe Ala Pro Ala Arg Cys Leu Thr Ile Ala Phe Lys
     130                 135                 140                
 Gly Arg Arg Lys Asn Leu Asp Leu Ala Ala Pro Thr Ala Glu Glu Ala
 145                 150                 155                 160
 Gln Arg Trp Val Arg Gly Leu Thr Lys Leu Arg Ala Arg Leu Asp Ala
                 165                 170                 175    
 Met Ser Gln Arg Glu Arg Leu Asp His Trp Ile His Ser Tyr Leu His
             180                 185                 190        
 Arg Ala Asp Ser Asn Gln Asp Ser Lys Met Ser Phe Lys Glu Ile Lys
         195                 200                 205            
 Ser Leu Leu Arg Met Val Asn Val Asp Met Asn Asp Met Tyr Ala Tyr
     210                 215                 220                
 Leu Leu Phe Lys Glu Cys Asp His Ser Asn Asn Asp Arg Leu Glu Gly
 225                 230                 235                 240
 Ala Glu Ile Glu Glu Phe Leu Arg Arg Leu Leu Lys Arg Pro Glu Leu
                 245                 250                 255    
 Glu Glu Ile Phe His Gln Tyr Ser Gly Glu Asp Arg Val Leu Ser Ala
             260                 265                 270        
 Pro Glu Leu Leu Glu Phe Leu Glu Asp Gln Gly Glu Glu Gly Ala Thr
         275                 280                 285            
 Leu Ala Arg Ala Gln Gln Leu Ile Gln Thr Tyr Glu Leu Asn Glu Thr
     290                 295                 300                
 Ala Lys Gln His Glu Leu Met Thr Leu Asp Gly Phe Met Met Tyr Leu
 305                 310                 315                 320
 Leu Ser Pro Glu Gly Ala Ala Leu Asp Asn Thr His Thr Cys Val Phe
                 325                 330                 335    
 Gln Asp Met Asn Gln Pro Leu Ala His Tyr Phe Ile Ser Ser Ser His
             340                 345                 350        
 Asn Thr Tyr Leu Thr Asp Ser Gln Ile Gly Gly Pro Ser Ser Thr Glu
         355                 360                 365            
 Ala Tyr Val Arg Tyr Cys Ser Arg Gly Ala Phe Ala Gln Gly Cys Arg
     370                 375                 380                
 Cys Val Glu Leu Asp Cys Trp Glu Gly Pro Gly Gly Glu Pro Val Ile
 385                 390                 395                 400
 Tyr His Gly His Thr Leu Thr Ser Lys Ile Leu Phe Arg Asp Val Val
                 405                 410                 415    
 Gln Ala Val Arg Asp His Ala Phe Thr Leu Ser Pro Tyr Pro Val Ile
             420                 425                 430        
 Leu Ser Leu Glu Asn His Cys Gly Leu Glu Gln Gln Ala Ala Met Ala
         435                 440                 445            
 Arg His Leu Cys Thr Ile Leu Gly Asp Met Leu Val Thr Gln Ala Leu
     450                 455                 460                
 Asp Ser Pro Asn Pro Glu Glu Leu Pro Ser Pro Glu Gln Leu Lys Gly
 465                 470                 475                 480
 Arg Val Leu Val Lys Gly Lys Lys Leu Pro Ala Ala Arg Ser Glu Asp
                 485                 490                 495    
 Gly Arg Ala Leu Ser Asp Arg Glu Glu Glu Glu Glu Asp Asp Glu Glu
             500                 505                 510        
 Glu Glu Glu Glu Val Glu Ala Ala Ala Gln Arg Arg Leu Ala Lys Gln
         515                 520                 525            
 Ile Ser Pro Glu Leu Ser Ala Leu Ala Val Tyr Cys His Ala Thr Arg
     530                 535                 540                
 Leu Arg Thr Leu His Pro Ala Pro Asn Ala Pro Gln Pro Cys Gln Val
 545                 550                 555                 560
 Ser Ser Leu Ser Glu Arg Lys Ala Lys Lys Leu Ile Arg Glu Ala Gly
                 565                 570                 575    
 Asn Ser Phe Val Arg His Asn Ala Arg Gln Leu Thr Arg Val Tyr Pro
             580                 585                 590        
 Leu Gly Leu Arg Met Asn Ser Ala Asn Tyr Ser Pro Gln Glu Met Trp
         595                 600                 605            
 Asn Ser Gly Cys Gln Leu Val Ala Leu Asn Phe Gln Thr Pro Gly Tyr
     610                 615                 620                
 Glu Met Asp Leu Asn Ala Gly Arg Phe Leu Val Asn Gly Gln Cys Gly
 625                 630                 635                 640
 Tyr Val Leu Lys Pro Ala Cys Leu Arg Gln Pro Asp Ser Thr Phe Asp
                 645                 650                 655    
 Pro Glu Tyr Pro Gly Pro Pro Arg Thr Thr Leu Ser Ile Gln Val Leu
             660                 665                 670        
 Thr Ala Gln Gln Leu Pro Lys Leu Asn Ala Glu Lys Pro His Ser Ile
         675                 680                 685            
 Val Asp Pro Leu Val Arg Ile Glu Ile His Gly Val Pro Ala Asp Cys
     690                 695                 700                
 Ala Arg Gln Glu Thr Asp Tyr Val Leu Asn Asn Gly Phe Asn Pro Arg
 705                 710                 715                 720
 Trp Gly Gln Thr Leu Gln Phe Gln Leu Arg Ala Pro Glu Leu Ala Leu
                 725                 730                 735    
 Val Arg Phe Val Val Glu Asp Tyr Asp Ala Thr Ser Pro Asn Asp Phe
             740                 745                 750        
 Val Gly Gln Phe Thr Leu Pro Leu Ser Ser Leu Lys Gln Gly Tyr Arg
         755                 760                 765            
 His Ile His Leu Leu Ser Lys Asp Gly Ala Ser Leu Ser Pro Ala Thr
     770                 775                 780                
 Leu Phe Ile Gln Ile Arg Ile Gln Arg Ser
 785                 790                



      <210> 122
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 122
 Met Val Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu
   1               5                  10                  15    
 Thr Ser Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly
              20                  25                  30        
 Glu Pro Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu
          35                  40                  45            
 Ala Leu Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln
      50                  55                  60                
 Leu Asp Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe
  65                  70                  75                  80
 Asn Val Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln
                  85                  90                  95    
 Met Pro Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala
             100                 105                 110        
 Tyr Gly Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys
         115                 120                 125            
 Gly Thr Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala
     130                 135                 140                
 Leu Trp Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser
 145                 150                 155                 160
 Leu Glu Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser
                 165                 170                 175    
 Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln
             180                 185                 190        
 Cys Leu Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu
         195                 200                 205            
 Phe Ser Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn
     210                 215                 220                
 Val Ser Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu
 225                 230                 235                 240
 Val Val Gln Ile Ala Gly Gln Trp Leu Leu Ala His Thr His Leu Pro
                 245                 250                 255    
 Ser Pro His Val Tyr Ile His Ile Gly Pro Lys Ala Val Tyr Lys Glu
             260                 265                 270        
 Thr Met Val Leu Arg Leu Ser Ala Tyr Arg Val Cys Trp Pro
         275                 280                 285    



      <210> 123
      <211> 551
      <212> PRT
      <213> Homo sapiens


      <400> 123
 Met Thr Ser Pro Gln Ala Asp Phe Cys Leu Gly Thr Ala Leu His Ser
   1               5                  10                  15    
 Trp Gly Leu Trp Phe Thr Glu Glu Gly Ser Pro Ser Thr Met Leu Thr
              20                  25                  30        
 Gly Ile Ala Val Gly Ala Leu Leu Ala Leu Ala Leu Val Gly Val Leu
          35                  40                  45            
 Ile Leu Phe Met Phe Arg Arg Leu Arg Gln Phe Arg Gln Ala Gln Pro
      50                  55                  60                
 Thr Pro Gln Tyr Arg Phe Arg Lys Arg Asp Lys Val Met Phe Tyr Gly
  65                  70                  75                  80
 Arg Lys Ile Met Arg Lys Val Thr Thr Leu Pro Asn Thr Leu Val Glu
                  85                  90                  95    
 Asn Thr Ala Leu Pro Arg Gln Arg Ala Arg Lys Arg Thr Lys Val Leu
             100                 105                 110        
 Ser Leu Ala Lys Arg Ile Leu Arg Phe Lys Lys Glu Tyr Pro Ala Leu
         115                 120                 125            
 Gln Pro Lys Glu Pro Pro Pro Ser Leu Leu Glu Ala Asp Leu Thr Glu
     130                 135                 140                
 Phe Asp Val Lys Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu
 145                 150                 155                 160
 Lys Asn Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu
                 165                 170                 175    
 Leu Cys Lys His Ile Val Phe Val Gln Leu Gln Glu Gly Glu His Val
             180                 185                 190        
 Phe Gln Pro Arg Glu Pro Asp Pro Ser Ile Cys Val Val Gln Asp Gly
         195                 200                 205            
 Arg Leu Glu Val Cys Ile Gln Asp Thr Asp Gly Thr Glu Val Val Val
     210                 215                 220                
 Lys Glu Val Leu Ala Gly Asp Ser Val His Ser Leu Leu Ser Ile Leu
 225                 230                 235                 240
 Asp Ile Ile Thr Gly His Ala Ala Pro Tyr Lys Thr Val Ser Val Arg
                 245                 250                 255    
 Ala Ala Ile Pro Ser Thr Ile Leu Arg Leu Pro Ala Ala Ala Phe His
             260                 265                 270        
 Gly Val Phe Glu Lys Tyr Pro Glu Thr Leu Val Arg Val Val Gln Ile
         275                 280                 285            
 Ile Met Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr
     290                 295                 300                
 Leu Gly Leu Thr Thr Glu Leu Phe Asn Ala Glu Ser Gln Ala Ile Pro
 305                 310                 315                 320
 Leu Val Ser Val Ala Ser Val Ala Ala Gly Lys Ala Lys Lys Gln Val
                 325                 330                 335    
 Phe Tyr Gly Glu Glu Glu Arg Leu Lys Lys Pro Pro Arg Leu Gln Glu
             340                 345                 350        
 Ser Cys Asp Ser Gly Thr Val Leu His Gln Gly Gly Gln Cys Pro Ala
         355                 360                 365            
 Pro Glu Ser Gly Gly Ser Cys Ser His Cys Leu Arg Ser Pro Gln Val
     370                 375                 380                
 Ile Leu His Met Pro Glu Ala Thr Thr His Ile Pro Gly Ser Pro His
 385                 390                 395                 400
 Thr Ala Gln Val Thr Leu Gln Val Pro Gln Val Thr Ser His Ala Pro
                 405                 410                 415    
 Gln Val Tyr Ser His Ala Pro Gln Val Pro Ser Arg Ala Ser Gly Pro
             420                 425                 430        
 Leu Thr Arg Ala Pro Gly His Leu Thr Cys Pro Pro Gly Leu Ile Arg
         435                 440                 445            
 Trp Pro Pro Arg Ser Pro His Val Ser Pro Ser Pro His Met Arg Ala
     450                 455                 460                
 Gly Cys Pro Gln Thr Ser Pro Gly Leu Ile Arg Cys Ala His Leu Leu
 465                 470                 475                 480
 Thr Cys Gly Leu Asp Val Leu Lys Pro Pro Thr Val Ser Leu Arg Val
                 485                 490                 495    
 Pro Val Ser Ser His Glu Ala Arg Met Ser Ser Asp Arg Pro Arg Thr
             500                 505                 510        
 Leu His Pro Pro Phe Phe Ser Cys Ser Gln Asn Ser Pro Leu Gly Gln
         515                 520                 525            
 Val Pro Gly Gly Glu Trp Ala Ser Arg Asp Gly Leu Ser Pro Ala Val
     530                 535                 540                
 Leu Ser Ala Asn Arg Gly Ala
 545                 550    



      <210> 124
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 124
 Met Ala Leu Pro Ala Leu Gly Leu Asp Pro Trp Ser Leu Leu Gly Leu
   1               5                  10                  15    
 Phe Leu Phe Gln Leu Leu Gln Leu Leu Leu Pro Thr Thr Thr Ala Gly
              20                  25                  30        
 Gly Gly Gly Gln Gly Pro Met Pro Arg Val Arg Tyr Tyr Ala Gly Asp
          35                  40                  45            
 Glu Arg Arg Ala Leu Ser Phe Phe His Gln Lys Gly Leu Gln Asp Phe
      50                  55                  60                
 Asp Thr Leu Leu Leu Ser Gly Asp Gly Asn Thr Leu Tyr Val Gly Ala
  65                  70                  75                  80
 Arg Glu Ala Ile Leu Ala Leu Asp Ile Gln Asp Pro Gly Val Pro Arg
                  85                  90                  95    
 Leu Lys Asn Met Ile Pro Trp Pro Ala Ser Asp Arg Lys Lys Ser Glu
             100                 105                 110        
 Cys Ala Phe Lys Lys Lys Ser Asn Glu Thr Gln Cys Phe Asn Phe Ile
         115                 120                 125            
 Arg Val Leu Val Ser Tyr Asn Val Thr His Leu Tyr Thr Cys Gly Thr
     130                 135                 140                
 Phe Ala Phe Ser Pro Ala Cys Thr Phe Ile Glu Leu Gln Asp Ser Tyr
 145                 150                 155                 160
 Leu Leu Pro Ile Ser Glu Asp Lys Val Met Glu Gly Lys Gly Gln Ser
                 165                 170                 175    
 Pro Phe Asp Pro Ala His Lys His Thr Ala Val Leu Val Asp Gly Met
             180                 185                 190        
 Leu Tyr Ser Gly Thr Met Asn Asn Phe Leu Gly Ser Glu Pro Ile Leu
         195                 200                 205            
 Met Arg Thr Leu Gly Ser Gln Pro Val Leu Lys Thr Asp Asn Phe Leu
     210                 215                 220                
 Arg Trp Leu His His Asp Ala Ser Phe Val Ala Ala Ile Pro Ser Thr
 225                 230                 235                 240
 Gln Val Val Tyr Phe Phe Phe Glu Glu Thr Ala Ser Glu Phe Asp Phe
                 245                 250                 255    
 Phe Glu Arg Leu His Thr Ser Arg Val Ala Arg Val Cys Lys Asn Asp
             260                 265                 270        
 Val Gly Gly Glu Lys Leu Leu Gln Lys Lys Trp Thr Thr Phe Leu Lys
         275                 280                 285            
 Ala Gln Leu Leu Cys Thr Gln Pro Gly Gln Leu Pro Phe Asn Val Ile
     290                 295                 300                
 Arg His Ala Val Leu Leu Pro Ala Asp Ser Pro Thr Ala Pro His Ile
 305                 310                 315                 320
 Tyr Ala Val Phe Thr Ser Gln Trp
                 325            



      <210> 125
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 125
 Met Met Glu Thr Met Gln Leu Lys Val Asn Arg His Pro Phe Cys Phe
   1               5                  10                  15    
 Ser Val Lys Gly Gln Val Lys Met Leu Gln Leu Met Arg Leu Gly Leu
              20                  25                  30        
 Arg Val Arg Gly Val Val Glu Ser Ala Cys Gly Arg Glu Met Trp Leu
          35                  40                  45            
 Cys Gly Tyr Lys Gly
      50            



      <210> 126
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 126
 Met Ala Cys Val Ser Val Asp His Tyr Pro Ala Val Val Cys Ala His
   1               5                  10                  15    
 Trp Gly Pro Cys Leu Arg Thr Ala Gly Arg Ala Arg Leu Val Cys Val
              20                  25                  30        
 Ala Ile Trp Thr Leu Val Leu Leu Gln Thr Met Pro Leu Leu Leu Met
          35                  40                  45            
 Pro Met Thr Lys Pro Leu Val Gly Lys Leu Ala Cys Met Glu Tyr Ser
      50                  55                  60                
 Ser Met Glu Ser Val Leu Gly Leu Pro Leu Met Val Leu Val Ala Phe
  65                  70                  75                  80
 Ala Ile Gly Phe Cys Gly Pro Val Gly Ile Ile Leu Ser Cys Tyr Met
                  85                  90                  95    
 Lys Ile Thr Trp Lys Leu Cys Ser Thr Ala Gly Arg Thr Gln
             100                 105                 110



      <210> 127
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 127
 Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr
   1               5                  10                  15    
 Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His
              20                  25                  30        
 Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr
          35                  40                  45            
 Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg
      50                  55                  60                
 Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr
  65                  70                  75                  80
 Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala
                  85                  90                  95    
 Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu
             100                 105                 110        
 Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu
         115                 120                 125            
 Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His
     130                 135                 140                
 Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln
 145                 150                 155                 160
 Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Gly Leu
                 165                 170                 175    
 Ser Ala Phe Lys Ser Gly Ile Glu Ala Ile Ala Thr Pro Ser Asp Ile
             180                 185                 190        
 Asp Asn Asp Phe Val Asn Asp Ile Ile Ala Arg Ala Lys Phe Tyr Lys
         195                 200                 205            
 Arg Gln Ser Phe
     210        



      <210> 128
      <211> 267
      <212> PRT
      <213> Homo sapiens


      <400> 128
 Met Ile Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu
   1               5                  10                  15    
 Leu Pro Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala
              20                  25                  30        
 Gly Val Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn
          35                  40                  45            
 His Asn Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg
      50                  55                  60                
 His Ser Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr
  65                  70                  75                  80
 Glu Lys Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala
                  85                  90                  95    
 Gln Asn Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala
             100                 105                 110        
 Val Leu Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val
         115                 120                 125            
 Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr
     130                 135                 140                
 Ala Tyr Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser
 145                 150                 155                 160
 Phe Pro Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys
                 165                 170                 175    
 Gln Ser Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn
             180                 185                 190        
 Lys Gln Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser
         195                 200                 205            
 Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp
     210                 215                 220                
 Gly Lys Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys
 225                 230                 235                 240
 Phe Pro His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys
                 245                 250                 255    
 Gln Glu Gly Lys Phe Glu Tyr Pro Ile Cys Glu
             260                 265        



      <210> 129
      <211> 1364
      <212> PRT
      <213> Homo sapiens


      <400> 129
 Met Gly Pro Asp Glu Ala Thr Pro Pro Asp Leu Val Leu Pro Ala Trp
   1               5                  10                  15    
 Arg Leu Arg His Gly Ala Phe Arg Thr Leu Val Thr Arg Glu Pro Gly
              20                  25                  30        
 Ala Pro Arg Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala
          35                  40                  45            
 Leu Ala Ala Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val
      50                  55                  60                
 Glu Pro Ser Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro
  65                  70                  75                  80
 Thr Ser Ser Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val
                  85                  90                  95    
 Phe Pro Ser Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys
             100                 105                 110        
 Ser Thr Trp Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe
         115                 120                 125            
 Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala
     130                 135                 140                
 Ala Tyr Glu Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser
 145                 150                 155                 160
 Arg Pro Val Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu
                 165                 170                 175    
 Glu Ala Ser Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu
             180                 185                 190        
 Pro Tyr Ser Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile
         195                 200                 205            
 Lys Val Ser Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp
     210                 215                 220                
 Ser Ala Leu Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly
 225                 230                 235                 240
 Leu Cys Gly Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala
                 245                 250                 255    
 His Ser Glu Cys His Leu Asp Ala Arg Leu Thr Pro Leu Gln Phe Gly
             260                 265                 270        
 Asn Leu Gln Lys Leu Asp Gly Pro Thr Glu Gln Cys Pro Asp Pro Leu
         275                 280                 285            
 Pro Leu Pro Ala Gly Asn Cys Thr Asp Glu Glu Gly Ile Cys His Arg
     290                 295                 300                
 Thr Leu Leu Gly Pro Ala Phe Ala Glu Cys His Ala Leu Val Asp Ser
 305                 310                 315                 320
 Thr Ala Tyr Leu Ala Ala Cys Ala Gln Asp Leu Cys Arg Cys Pro Thr
                 325                 330                 335    
 Cys Pro Cys Ala Thr Phe Val Glu Tyr Ser Arg Gln Cys Ala His Ala
             340                 345                 350        
 Gly Gly Gln Pro Arg Asn Trp Arg Cys Pro Glu Leu Cys Pro Arg Thr
         355                 360                 365            
 Cys Pro Leu Asn Met Gln His Gln Glu Cys Gly Ser Pro Cys Thr Asp
     370                 375                 380                
 Thr Cys Ser Asn Pro Gln Arg Ala Gln Leu Cys Glu Asp His Cys Val
 385                 390                 395                 400
 Asp Gly Cys Phe Cys Pro Pro Gly Thr Val Leu Asp Asp Ile Thr His
                 405                 410                 415    
 Ser Gly Cys Leu Pro Leu Gly Gln Cys Pro Cys Thr His Gly Gly Arg
             420                 425                 430        
 Thr Tyr Ser Pro Gly Thr Ser Phe Asn Thr Thr Cys Ser Ser Cys Thr
         435                 440                 445            
 Cys Ser Gly Gly Leu Trp Gln Cys Gln Asp Leu Pro Cys Pro Gly Thr
     450                 455                 460                
 Cys Ser Val Gln Gly Gly Ala His Ile Ser Thr Tyr Asp Glu Lys Leu
 465                 470                 475                 480
 Tyr Asp Leu His Gly Asp Cys Ser Tyr Val Leu Ser Lys Lys Cys Ala
                 485                 490                 495    
 Asp Ser Ser Phe Thr Val Leu Ala Glu Leu Arg Lys Cys Gly Leu Thr
             500                 505                 510        
 Asp Asn Glu Asn Cys Leu Lys Ala Val Thr Leu Ser Leu Asp Gly Gly
         515                 520                 525            
 Asp Thr Ala Ile Arg Val Gln Ala Asp Gly Gly Val Phe Leu Asn Ser
     530                 535                 540                
 Ile Tyr Thr Gln Leu Pro Leu Ser Ala Ala Asn Ile Thr Leu Phe Thr
 545                 550                 555                 560
 Pro Ser Ser Phe Phe Ile Val Val Gln Thr Gly Leu Gly Leu Gln Leu
                 565                 570                 575    
 Leu Val Gln Leu Val Pro Leu Met Gln Val Phe Val Arg Leu Asp Pro
             580                 585                 590        
 Ala His Gln Gly Gln Met Cys Gly Leu Cys Gly Asn Phe Asn Gln Asn
         595                 600                 605            
 Gln Ala Asp Asp Phe Thr Ala Leu Ser Gly Val Val Glu Ala Thr Gly
     610                 615                 620                
 Ala Ala Phe Ala Asn Thr Trp Lys Ala Gln Ala Ala Cys Ala Asn Ala
 625                 630                 635                 640
 Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn Glu Asn
                 645                 650                 655    
 Tyr Ala Arg His Trp Cys Ser Arg Leu Thr Asp Pro Asn Ser Ala Phe
             660                 665                 670        
 Ser Arg Cys His Ser Ile Ile Asn Pro Lys Pro Phe His Ser Asn Cys
         675                 680                 685            
 Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu Cys Ala
     690                 695                 700                
 Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val Gln Leu
 705                 710                 715                 720
 Ser Asp Trp Arg Asp Gly Val Cys Thr Lys Tyr Met Gln Asn Cys Pro
                 725                 730                 735    
 Lys Ser Gln Arg Tyr Ala Tyr Val Val Asp Ala Cys Gln Pro Thr Cys
             740                 745                 750        
 Arg Gly Leu Ser Glu Ala Asp Val Thr Cys Ser Val Ser Phe Val Pro
         755                 760                 765            
 Val Asp Gly Cys Thr Cys Pro Ala Gly Thr Phe Leu Asn Asp Ala Gly
     770                 775                 780                
 Ala Cys Val Pro Ala Gln Lys Cys Pro Cys Tyr Ala His Gly Thr Val
 785                 790                 795                 800
 Leu Ala Pro Gly Glu Val Val His Asp Glu Gly Ala Val Cys Ser Cys
                 805                 810                 815    
 Thr Gly Gly Lys Leu Ser Cys Leu Gly Ala Ser Leu Gln Lys Ser Thr
             820                 825                 830        
 Gly Cys Ala Ala Pro Met Val Tyr Leu Asp Cys Ser Asn Ser Ser Ala
         835                 840                 845            
 Gly Thr Pro Gly Ala Glu Cys Leu Arg Ser Cys His Thr Leu Asp Val
     850                 855                 860                
 Gly Cys Phe Ser Thr His Cys Val Ser Gly Cys Val Cys Pro Pro Gly
 865                 870                 875                 880
 Leu Val Ser Asp Gly Ser Gly Gly Cys Ile Ala Glu Glu Asp Cys Pro
                 885                 890                 895    
 Cys Val His Asn Glu Ala Thr Tyr Lys Pro Gly Glu Thr Ile Arg Val
             900                 905                 910        
 Asp Cys Asn Thr Cys Thr Cys Arg Asn Arg Arg Trp Glu Cys Ser His
         915                 920                 925            
 Arg Leu Cys Leu Gly Thr Cys Val Ala Tyr Gly Asp Gly His Phe Ile
     930                 935                 940                
 Thr Phe Asp Gly Asp Arg Tyr Ser Phe Glu Gly Ser Cys Glu Tyr Ile
 945                 950                 955                 960
 Leu Ala Gln Asp Tyr Cys Gly Asp Asn Thr Thr His Gly Thr Phe Arg
                 965                 970                 975    
 Ile Val Thr Glu Asn Ile Pro Cys Gly Thr Thr Gly Thr Thr Cys Ser
             980                 985                 990        
 Lys Ala Ile Lys Leu Phe Val Glu Ser Tyr Glu Leu Ile Leu Gln Glu
         995                1000                1005            
 Gly Thr Phe Lys Ala Val Ala Arg Gly Pro Gly Gly Asp Pro Pro Tyr
    1010                1015                1020                
 Lys Ile Arg Tyr Met Gly Ile Phe Leu Val Ile Glu Thr His Gly Met
1025                1030                1035                1040
 Ala Val Ser Trp Asp Arg Lys Thr Ser Val Phe Ile Arg Leu His Gln
                1045                1050                1055    
 Asp Tyr Lys Gly Arg Val Cys Gly Leu Cys Gly Asn Phe Asp Asp Asn
            1060                1065                1070        
 Ala Ile Asn Asp Phe Ala Thr Arg Ser Arg Ser Val Val Gly Asp Ala
        1075                1080                1085            
 Leu Glu Phe Gly Asn Ser Trp Lys Leu Ser Pro Ser Cys Pro Asp Ala
    1090                1095                1100                
 Leu Ala Pro Lys Asp Pro Cys Thr Ala Asn Pro Phe Arg Lys Ser Trp
1105                1110                1115                1120
 Ala Gln Lys Gln Cys Ser Ile Leu His Gly Pro Thr Phe Ala Ala Cys
                1125                1130                1135    
 Arg Ser Gln Val Asp Ser Thr Lys Tyr Tyr Glu Ala Cys Val Asn Asp
            1140                1145                1150        
 Ala Cys Ala Cys Asp Ser Gly Gly Asp Cys Glu Cys Phe Cys Thr Ala
        1155                1160                1165            
 Val Ala Ala Tyr Ala Gln Ala Cys His Asp Ala Gly Leu Cys Val Ser
    1170                1175                1180                
 Trp Arg Thr Pro Asp Thr Cys Pro Leu Phe Cys Asp Phe Tyr Asn Pro
1185                1190                1195                1200
 His Gly Gly Cys Glu Trp His Tyr Gln Pro Cys Gly Ala Pro Cys Leu
                1205                1210                1215    
 Lys Thr Cys Arg Asn Pro Ser Gly His Cys Leu Val Asp Leu Pro Gly
            1220                1225                1230        
 Leu Glu Gly Cys Tyr Pro Lys Cys Pro Pro Ser Gln Pro Phe Phe Asn
        1235                1240                1245            
 Glu Asp Gln Met Lys Cys Val Ala Gln Cys Gly Cys Tyr Asp Lys Asp
    1250                1255                1260                
 Gly Asn Tyr Tyr Asp Val Gly Ala Arg Val Pro Thr Ala Glu Asn Cys
1265                1270                1275                1280
 Gln Ser Cys Asn Cys Thr Pro Ser Gly Ile Gln Cys Ala His Ser Leu
                1285                1290                1295    
 Glu Ala Cys Thr Cys Thr Tyr Glu Asp Arg Thr Tyr Ser Tyr Gln Asp
            1300                1305                1310        
 Val Ile Tyr Asn Thr Thr Asp Gly Leu Gly Ala Cys Leu Ile Ala Ile
        1315                1320                1325            
 Cys Gly Ser Asn Gly Thr Ile Ile Arg Lys Ala Val Ala Cys Pro Gly
    1330                1335                1340                
 Thr Pro Ala Thr Thr Pro Phe Thr Phe Thr Thr Ala Trp Val Pro His
1345                1350                1355                1360
 Ser Thr Thr Ser
                



      <210> 130
      <211> 1296
      <212> PRT
      <213> Homo sapiens


      <400> 130
 Met Ser Thr Ser Asp Ile Pro Ser Ser Pro Ser Ile Gln Asn Thr Glu
   1               5                  10                  15    
 Thr Ser Ser Leu Val Ser Met Thr Ser Ala Thr Ile Pro Ser Val Arg
              20                  25                  30        
 Pro Thr Phe Thr Ser Thr His Asn Thr Leu Thr Ser Ser Leu Leu Thr
          35                  40                  45            
 Thr Phe Pro Gly Thr Tyr Ser Phe Ser Ser Ser Met Ser Ala Ser Ser
      50                  55                  60                
 Asp Gly Thr Thr His Thr Glu Thr Ile Thr Ser Leu Pro Ala Ser Thr
  65                  70                  75                  80
 Ser Thr Leu His Thr Thr Ala Glu Ser Thr Thr Ala His Thr Thr Thr
                  85                  90                  95    
 Thr Ser Phe Thr Thr Ser Thr Thr Met Glu Ser Pro Ser Ser Ser Val
             100                 105                 110        
 Ala Thr Thr Ser Thr Gly Gln Thr Thr Phe Ser Ser Ser Thr Ala Thr
         115                 120                 125            
 Phe Thr Glu Thr Thr Thr Leu Thr Pro Thr Thr Asp Phe Ser Glu Glu
     130                 135                 140                
 Thr Leu Thr Thr Ala Met Thr Ser Thr Pro Pro Ile Thr Ser Ser Ile
 145                 150                 155                 160
 Thr Pro Thr Asn Thr Val Thr Ser Met Thr Thr Met Thr Ser Trp Pro
                 165                 170                 175    
 Thr Ala Thr Asn Thr Leu Ser Ser Leu Thr Thr Asn Ile Leu Ser Ser
             180                 185                 190        
 Thr Pro Val Pro Ser Thr Glu Arg Thr Thr Ser His Thr Thr Asn Ile
         195                 200                 205            
 Asn Pro Val Ser Thr Leu Val Thr Thr Leu Pro Thr Thr Ile Thr Arg
     210                 215                 220                
 Ser Thr Pro Thr Ser Glu Thr Thr Tyr Pro Ile Ser Ser Thr Ser Thr
 225                 230                 235                 240
 Val Thr Glu Ser Thr Thr Glu Ile Thr Tyr Ser Thr Thr Met Thr Glu
                 245                 250                 255    
 Thr Ser Ser Ser Ala Thr Ser Leu Pro Leu Thr Ser Pro Leu Val Ser
             260                 265                 270        
 Thr Thr Glu Thr Ala Lys Thr Pro Thr Thr Ile Leu Val Thr Thr Thr
         275                 280                 285            
 Thr Lys Thr Thr Ser His Ser Thr Thr Ser Phe Thr Ser Ser Thr Val
     290                 295                 300                
 Tyr Ser Thr Ala Ser Thr His Thr Thr Ala Ile Thr Ser Val Pro Thr
 305                 310                 315                 320
 Thr Leu Gly Thr Met Val Thr Ser Thr Ser Arg Ile Pro Ser Thr Val
                 325                 330                 335    
 Ser Thr Ser Ile Pro Thr Ser Gln Pro Lys Thr Val Asn Ser Ser Ser
             340                 345                 350        
 Gly Gly Ile Thr Gly Ser Leu Pro Met Met Thr Asp Leu Thr Ser Gly
         355                 360                 365            
 Tyr Thr Val Ser Ser Met Ser Ala Ile Pro Thr Thr Val Ile Pro Thr
     370                 375                 380                
 Ser Leu Thr Val Gln Asn Thr Glu Thr Ser Ile Phe Val Ser Met Thr
 385                 390                 395                 400
 Ser Ala Thr Thr Pro Ser Gly Arg Pro Thr Phe Thr Ser Thr Val Asn
                 405                 410                 415    
 Thr Pro Thr Arg Ser Leu Leu Thr Ser Phe Pro Thr Thr His Leu Phe
             420                 425                 430        
 Ser Ser Ser Met Ser Glu Ser Ser Ala Gly Thr Thr His Thr Glu Ser
         435                 440                 445            
 Ile Ser Ser Pro Pro Ala Thr Thr Ser Thr Leu His Thr Thr Ala Glu
     450                 455                 460                
 Ser Thr Pro Ser Cys Thr Thr Thr Thr Ser Phe Ile Thr Ser Thr Thr
 465                 470                 475                 480
 Met Glu Pro Leu Ser Thr Ile Val Ala Thr Thr Gly Thr Val Lys Thr
                 485                 490                 495    
 Thr Val Thr Ser Ser Thr Ala Thr Phe Arg Glu Thr Thr Thr Leu Thr
             500                 505                 510        
 Ser Thr Thr Asp Ile Ser Thr Glu Ser Leu Met Thr Ala Met Thr Ser
         515                 520                 525            
 Thr Thr Arg Leu Thr Ser Ala Ile Thr Ser Lys Thr Thr Leu Thr Ser
     530                 535                 540                
 Leu Lys Thr Thr Ala Ser Arg Pro Thr Ala Asn Ser Thr Leu Ser Ser
 545                 550                 555                 560
 Leu Thr Ser Ser Ile Leu Ser Ser Thr Leu Val Pro Ser Thr Asp Met
                 565                 570                 575    
 Ile Thr Ser His Thr Thr Asn Leu Thr Arg Ser Ser Pro Leu Leu Ala
             580                 585                 590        
 Thr Leu Pro Thr Thr Ile Thr Arg Ser Thr Pro Thr Ser Glu Thr Thr
         595                 600                 605            
 Tyr Pro Thr Ser Pro Thr Ser Thr Val Lys Gly Ser Thr Thr Ser Ile
     610                 615                 620                
 Arg Tyr Ser Thr Ser Met Thr Gly Thr Leu Ser Met Glu Thr Ser Leu
 625                 630                 635                 640
 Pro Pro Thr Ser Ser Ser Leu Pro Thr Thr Glu Thr Ala Thr Met Thr
                 645                 650                 655    
 Pro Thr Thr Thr Leu Ile Thr Thr Thr Pro Asn Thr Thr Ser His Ser
             660                 665                 670        
 Thr Pro Ser Phe Thr Ser Ser Thr Ile Tyr Ser Thr Val Ser Thr Ser
         675                 680                 685            
 Thr Thr Ala Ile Thr Ser His Phe Thr Thr Ser Glu Thr Ala Val Thr
     690                 695                 700                
 Pro Thr Pro Val Thr Pro Ser Ser Leu Ser Thr Asp Ile Pro Thr Thr
 705                 710                 715                 720
 Ser Leu Arg Thr Leu Thr Pro Ser Ser Val Gly Thr Ser Thr Ser Leu
                 725                 730                 735    
 Thr Thr Thr Thr Asp Phe Pro Ser Ile Pro Thr Asp Ile Ser Thr Leu
             740                 745                 750        
 Pro Thr Arg Thr His Ile Ile Ser Ser Ser Pro Ser Ile Gln Ser Thr
         755                 760                 765            
 Glu Thr Ser Ser Leu Val Gly Thr Thr Ser Pro Thr Met Ser Thr Val
     770                 775                 780                
 Arg Met Thr Leu Arg Ile Thr Glu Asn Thr Pro Ile Ser Ser Phe Ser
 785                 790                 795                 800
 Thr Ser Ile Val Val Ile Pro Glu Thr Pro Thr Gln Thr Pro Pro Val
                 805                 810                 815    
 Leu Thr Ser Ala Thr Gly Thr Gln Thr Ser Pro Ala Pro Thr Thr Val
             820                 825                 830        
 Thr Phe Gly Ser Thr Asp Ser Ser Thr Ser Thr Leu His Thr Leu Thr
         835                 840                 845            
 Pro Ser Thr Ala Leu Ser Thr Ile Val Ser Thr Ser Gln Val Pro Ile
     850                 855                 860                
 Pro Ser Thr His Ser Ser Thr Leu Gln Thr Thr Pro Ser Thr Pro Ser
 865                 870                 875                 880
 Leu Gln Thr Ser Leu Thr Ser Thr Ser Glu Phe Thr Thr Glu Ser Phe
                 885                 890                 895    
 Thr Arg Gly Ser Thr Ser Thr Asn Ala Ile Leu Thr Ser Phe Ser Thr
             900                 905                 910        
 Ile Ile Trp Ser Ser Thr Pro Thr Ile Ile Met Ser Ser Ser Pro Ser
         915                 920                 925            
 Ser Ala Ser Ile Thr Pro Val Phe Ser Thr Thr Ile His Ser Val Pro
     930                 935                 940                
 Ser Ser Pro Tyr Ile Phe Ser Thr Glu Asn Val Gly Ser Ala Ser Ile
 945                 950                 955                 960
 Thr Gly Phe Pro Ser Leu Ser Ser Ser Ala Thr Thr Ser Thr Ser Ser
                 965                 970                 975    
 Thr Ser Ser Ser Leu Thr Thr Ala Leu Thr Glu Ile Thr Pro Phe Ser
             980                 985                 990        
 Tyr Ile Ser Leu Pro Ser Thr Thr Pro Cys Pro Gly Thr Ile Thr Ile
         995                1000                1005            
 Thr Ile Val Pro Ala Ser Pro Thr Asp Pro Cys Val Glu Met Asp Pro
    1010                1015                1020                
 Ser Thr Glu Ala Thr Ser Pro Pro Thr Thr Pro Leu Thr Val Phe Pro
1025                1030                1035                1040
 Phe Thr Thr Glu Met Val Thr Cys Pro Thr Ser Ile Ser Ile Gln Thr
                1045                1050                1055    
 Thr Leu Thr Thr Tyr Met Asp Thr Ser Ser Met Met Pro Glu Ser Glu
            1060                1065                1070        
 Ser Ser Ile Ser Pro Asn Ala Ser Ser Ser Thr Gly Thr Gly Thr Val
        1075                1080                1085            
 Pro Thr Asn Thr Val Phe Thr Ser Thr Arg Leu Pro Thr Ser Glu Thr
    1090                1095                1100                
 Trp Leu Ser Asn Ser Ser Val Ile Pro Leu Pro Leu Pro Gly Val Ser
1105                1110                1115                1120
 Thr Ile Pro Leu Thr Met Lys Pro Ser Ser Ser Leu Pro Thr Ile Leu
                1125                1130                1135    
 Arg Thr Ser Ser Lys Ser Thr His Pro Ser Pro Pro Thr Thr Arg Thr
            1140                1145                1150        
 Ser Glu Thr Pro Val Ala Thr Thr Gln Thr Pro Thr Thr Leu Thr Ser
        1155                1160                1165            
 Arg Arg Thr Thr Arg Ile Thr Ser Gln Met Thr Thr Gln Ser Thr Leu
    1170                1175                1180                
 Thr Thr Thr Ala Gly Thr Cys Asp Asn Gly Gly Thr Trp Glu Gln Gly
1185                1190                1195                1200
 Gln Cys Ala Cys Leu Pro Gly Phe Ser Gly Asp Arg Cys Gln Leu Gln
                1205                1210                1215    
 Thr Arg Cys Gln Asn Gly Gly Gln Trp Asp Gly Leu Lys Cys Gln Cys
            1220                1225                1230        
 Pro Ser Thr Phe Tyr Gly Ser Ser Cys Glu Phe Ala Val Glu Gln Val
        1235                1240                1245            
 Asp Leu Asp Ala Glu Asp Phe Cys Arg His Ala Gly Leu His Leu Gln
    1250                1255                1260                
 Gly Cys Gly Asp Pro Val Pro Glu Glu Trp Gln His Arg Gly Gly Leu
1265                1270                1275                1280
 Pro Gly Pro Ala Gly Asp Ala Leu Gln Pro Pro Ala Gly Glu Arg Val
                1285                1290                1295    





      <210> 131
      <211> 319
      <212> PRT
      <213> Homo sapiens


      <400> 131
 Met Thr Arg Thr Tyr Glu Asn Phe Gln Tyr Leu Glu Asn Lys Val Lys
   1               5                  10                  15    
 Val Gln Gly Phe Lys Asn Gly Pro Leu Pro Leu Gln Ser Leu Leu Gln
              20                  25                  30        
 Arg Leu Cys Ser Gly Pro Cys His Leu Leu Leu Ser Leu Gly Leu Gly
          35                  40                  45            
 Leu Leu Leu Leu Val Ile Ile Cys Val Val Gly Phe Gln Asn Ser Lys
      50                  55                  60                
 Phe Gln Arg Asp Leu Val Thr Leu Arg Thr Asp Phe Ser Asn Phe Thr
  65                  70                  75                  80
 Ser Asn Thr Val Ala Glu Ile Gln Ala Leu Thr Ser Gln Gly Ser Ser
                  85                  90                  95    
 Leu Glu Glu Thr Ile Ala Ser Leu Lys Ala Glu Val Glu Gly Phe Lys
             100                 105                 110        
 Gln Glu Arg Gln Ala Gly Val Ser Glu Leu Gln Glu His Thr Thr Gln
         115                 120                 125            
 Lys Ala His Leu Gly His Cys Pro His Cys Pro Ser Val Cys Val Pro
     130                 135                 140                
 Val His Ser Glu Met Leu Leu Arg Val Gln Gln Leu Val Gln Asp Leu
 145                 150                 155                 160
 Lys Lys Leu Thr Cys Gln Val Ala Thr Leu Asn Asn Asn Gly Glu Glu
                 165                 170                 175    
 Ala Ser Thr Glu Gly Thr Cys Cys Pro Val Asn Trp Val Glu His Gln
             180                 185                 190        
 Asp Ser Cys Tyr Trp Phe Ser His Ser Gly Met Ser Trp Ala Glu Ala
         195                 200                 205            
 Glu Lys Tyr Cys Gln Leu Lys Asn Ala His Leu Val Val Ile Asn Ser
     210                 215                 220                
 Arg Glu Glu Gln Asn Phe Val Gln Lys Tyr Leu Gly Ser Ala Tyr Thr
 225                 230                 235                 240
 Trp Met Gly Leu Ser Asp Pro Glu Gly Ala Trp Lys Trp Val Asp Gly
                 245                 250                 255    
 Thr Asp Tyr Ala Thr Gly Phe Gln Asn Trp Lys Pro Gly Gln Pro Asp
             260                 265                 270        
 Asp Trp Gln Gly His Gly Leu Gly Gly Gly Glu Asp Cys Ala His Phe
         275                 280                 285            
 His Pro Asp Gly Arg Trp Asn Asp Asp Val Cys Gln Arg Pro Tyr His
     290                 295                 300                
 Trp Val Cys Glu Ala Gly Leu Gly Gln Thr Ser Gln Glu Ser His
 305                 310                 315                



      <210> 132
      <211> 590
      <212> PRT
      <213> Homo sapiens


      <400> 132
 Met Lys Glu Val Thr Phe His Cys His Glu Gly Tyr Ile Leu His Gly
   1               5                  10                  15    
 Ala Pro Lys Leu Thr Cys Gln Ser Asp Gly Asn Trp Asp Ala Glu Ile
              20                  25                  30        
 Pro Leu Cys Lys Pro Val Asn Cys Gly Pro Pro Glu Asp Leu Ala His
          35                  40                  45            
 Gly Phe Pro Asn Gly Phe Ser Phe Ile His Gly Gly His Ile Gln Tyr
      50                  55                  60                
 Gln Cys Phe Pro Gly Tyr Lys Leu His Gly Asn Ser Ser Arg Arg Cys
  65                  70                  75                  80
 Leu Ser Asn Gly Ser Trp Ser Gly Ser Ser Pro Ser Cys Leu Pro Cys
                  85                  90                  95    
 Arg Cys Ser Thr Pro Val Ile Glu Tyr Gly Thr Val Asn Gly Thr Asp
             100                 105                 110        
 Phe Asp Cys Gly Lys Ala Ala Arg Ile Gln Cys Phe Lys Gly Phe Lys
         115                 120                 125            
 Leu Leu Gly Leu Ser Glu Ile Thr Cys Glu Ala Asp Gly Gln Trp Ser
     130                 135                 140                
 Ser Gly Phe His His Phe Glu His Thr Ser Cys Gly Ser Leu Pro Met
 145                 150                 155                 160
 Ile Pro Asn Ala Phe Ile Ser Glu Thr Ser Ser Trp Lys Glu Asn Val
                 165                 170                 175    
 Ile Thr Tyr Ser Cys Arg Ser Gly Tyr Val Ile Gln Gly Ser Ser Asp
             180                 185                 190        
 Leu Ile Cys Thr Glu Lys Gly Val Trp Ser Gln Pro Tyr Pro Val Cys
         195                 200                 205            
 Glu Pro Leu Ser Cys Gly Ser Pro Pro Ser Val Ala Asn Ala Val Ala
     210                 215                 220                
 Thr Gly Glu Ala His Thr Tyr Glu Ser Glu Val Lys Leu Arg Cys Leu
 225                 230                 235                 240
 Glu Gly Tyr Thr Met Asp Thr Asp Thr Arg Ser Ile Thr Cys Gln Lys
                 245                 250                 255    
 Asp Gly Arg Trp Phe Pro Glu Arg Ile Ser Cys Ser Pro Lys Lys Cys
             260                 265                 270        
 Pro Leu Pro Glu Asn Ile Thr His Ile Leu Val His Gly Asp Asp Phe
         275                 280                 285            
 Ser Val Asn Arg Gln Val Ser Val Ser Cys Ala Glu Gly Tyr Thr Phe
     290                 295                 300                
 Glu Gly Val Asn Ile Ser Val Cys Gln Leu Asp Gly Thr Trp Glu Pro
 305                 310                 315                 320
 Pro Phe Ser Asp Glu Ser Cys Ser Pro Val Ser Cys Gly Lys Pro Glu
                 325                 330                 335    
 Ser Pro Glu His Gly Phe Val Val Gly Ser Lys Tyr Thr Phe Glu Ser
             340                 345                 350        
 Thr Ile Ile Tyr Gln Cys Glu Pro Gly Tyr Glu Leu Glu Gly Asn Arg
         355                 360                 365            
 Glu Arg Val Cys Gln Glu Asn Arg Gln Trp Ser Gly Gly Val Ala Ile
     370                 375                 380                
 Cys Lys Glu Thr Arg Cys Glu Thr Pro Leu Glu Phe Leu Asn Gly Lys
 385                 390                 395                 400
 Ala Asp Ile Glu Asn Arg Thr Thr Gly Pro Asn Val Val Tyr Ser Cys
                 405                 410                 415    
 Asn Arg Gly Tyr Ser Leu Glu Gly Pro Ser Glu Ala His Cys Thr Glu
             420                 425                 430        
 Asn Gly Thr Trp Ser His Pro Val Pro Leu Cys Lys Pro Asn Pro Cys
         435                 440                 445            
 Pro Val Pro Phe Val Ile Pro Glu Asn Ala Leu Leu Ser Glu Lys Glu
     450                 455                 460                
 Phe Tyr Val Asp Gln Asn Val Ser Ile Lys Cys Arg Glu Gly Phe Leu
 465                 470                 475                 480
 Leu Gln Gly His Gly Ile Ile Thr Cys Asn Pro Asp Glu Thr Trp Thr
                 485                 490                 495    
 Gln Thr Ser Ala Lys Cys Glu Lys Ile Ser Cys Gly Pro Pro Ala His
             500                 505                 510        
 Val Glu Asn Ala Ile Ala Arg Gly Val His Tyr Gln Tyr Gly Asp Met
         515                 520                 525            
 Ile Thr Tyr Ser Cys Tyr Ser Gly Tyr Met Leu Glu Gly Phe Leu Arg
     530                 535                 540                
 Ser Val Cys Leu Glu Asn Gly Thr Trp Thr Ser Pro Pro Ile Cys Arg
 545                 550                 555                 560
 Ala Val Cys Arg Phe Pro Cys Gln Asn Gly Gly Ile Cys Gln Arg Pro
                 565                 570                 575    
 Asn Ala Cys Ser Cys Pro Glu Gly Trp Asp Gly Ala Pro Leu
             580                 585                 590



      <210> 133
      <211> 1544
      <212> PRT
      <213> Homo sapiens


      <400> 133
 Met Ser Gly Thr Gln Ser Thr Ile Thr Asp Arg Phe Pro Leu Lys Lys
   1               5                  10                  15    
 Pro Ile Arg His Gly Ser Ile Leu Asn Arg Glu Ser Pro Thr Asp Lys
              20                  25                  30        
 Lys Gln Lys Val Glu Arg Ile Ala Ser His Asp Phe Asp Pro Thr Asp
          35                  40                  45            
 Ser Ser Ser Lys Lys Thr Lys Ser Ser Ser Glu Glu Ser Arg Ser Glu
      50                  55                  60                
 Ile Tyr Gly Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Asp Asn
  65                  70                  75                  80
 Gly Phe Gly Leu Thr Val Ser Gly Asp Asn Pro Val Phe Val Gln Ser
                  85                  90                  95    
 Val Lys Glu Asp Gly Ala Ala Met Arg Ala Gly Val Gln Thr Gly Asp
             100                 105                 110        
 Arg Ile Ile Lys Val Asn Gly Thr Leu Val Thr His Ser Asn His Leu
         115                 120                 125            
 Glu Val Val Lys Leu Ile Lys Ser Gly Ser Tyr Val Ala Leu Thr Val
     130                 135                 140                
 Gln Gly Arg Pro Pro Gly Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu
 145                 150                 155                 160
 Val Glu Pro Ser Val Ile Gly His Met Ser Pro Ile Met Thr Ser Pro
                 165                 170                 175    
 His Ser Pro Gly Ala Ser Gly Asn Met Glu Arg Ile Thr Ser Pro Val
             180                 185                 190        
 Leu Met Gly Glu Glu Asn Asn Val Val His Asn Gln Lys Val Glu Ile
         195                 200                 205            
 Leu Arg Lys Met Leu Gln Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln
     210                 215                 220                
 Glu Asp Tyr Asn Arg Thr Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln
 225                 230                 235                 240
 Glu Ala Lys Lys His Ile Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala
                 245                 250                 255    
 Thr Gly Ser Ala Gln Asp Gly Ala Val Val Thr Pro Ser Arg Pro Leu
             260                 265                 270        
 Gly Asp Thr Leu Thr Val Ser Glu Ala Glu Thr Asp Pro Gly Asp Val
         275                 280                 285            
 Leu Gly Arg Thr Asp Cys Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser
     290                 295                 300                
 Asp Asn Ala Asp Ser Pro Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu
 305                 310                 315                 320
 Glu Glu Asn Pro Glu Lys Ser Glu Thr Ile Gln Asp Thr Asp Thr Gln
                 325                 330                 335    
 Ser Leu Val Gly Ser Pro Ser Thr Arg Ile Ala Pro His Ile Ile Gly
             340                 345                 350        
 Ala Glu Asp Asp Asp Phe Gly Thr Glu His Glu Gln Ile Asn Gly Gln
         355                 360                 365            
 Cys Ser Cys Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His
     370                 375                 380                
 Leu Ala Val Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Thr
 385                 390                 395                 400
 Leu Leu Cys Tyr Leu Tyr Ser Asp Leu Tyr Lys His Thr Asn Ser Lys
                 405                 410                 415    
 Glu Thr Arg Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg
             420                 425                 430        
 Ser Ala His Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu
         435                 440                 445            
 Glu Lys Arg Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr
     450                 455                 460                
 Ile Gln Thr Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu
 465                 470                 475                 480
 Lys Asp Phe Arg Gln Lys Arg Ser Met Gly Leu Thr Leu Ala Glu Ser
                 485                 490                 495    
 Glu Leu Thr Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Thr Leu
             500                 505                 510        
 Glu Lys Glu Arg Thr Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu
         515                 520                 525            
 Val Leu Met Thr Ala Gln Ala Val Glu Glu Asp Lys Ser Ser Thr Met
     530                 535                 540                
 Gln Tyr Val Ile Leu Met Tyr Met Lys His Leu Gly Val Lys Val Lys
 545                 550                 555                 560
 Glu Pro Arg Asn Leu Glu His Lys Arg Gly Arg Ile Gly Phe Leu Pro
                 565                 570                 575    
 Lys Ile Lys Gln Ser Met Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly
             580                 585                 590        
 Lys Arg Arg Gly Phe Pro Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser
         595                 600                 605            
 Arg His Asp Asn Ser Ala Ile Gly Arg Ala Met Glu Leu Gln Lys Ala
     610                 615                 620                
 Arg His Pro Lys His Leu Ser Thr Pro Ser Ser Val Ser Pro Glu Pro
 625                 630                 635                 640
 Gln Asp Ser Ala Lys Leu Arg Gln Ser Gly Leu Ala Asn Glu Gly Thr
                 645                 650                 655    
 Asp Ala Gly Tyr Leu Pro Ala Asn Ser Met Ser Ser Val Ala Ser Gly
             660                 665                 670        
 Ala Ser Phe Ser Gln Glu Gly Gly Lys Glu Asn Asp Thr Gly Ser Lys
         675                 680                 685            
 Gln Val Gly Glu Thr Ser Ala Pro Gly Asp Thr Leu Asp Gly Thr Pro
     690                 695                 700                
 Arg Thr Leu Asn Thr Val Phe Val Phe Pro Pro Pro Pro Leu Asp Gln
 705                 710                 715                 720
 Val Gln Glu Glu Glu Cys Glu Val Glu Arg Val Thr Glu His Gly Thr
                 725                 730                 735    
 Pro Lys Pro Phe Arg Lys Phe Asp Ser Val Ala Phe Gly Glu Ser Gln
             740                 745                 750        
 Ser Glu Asp Glu Gln Phe Glu Asn Asp Leu Glu Thr Asp Pro Pro Asn
         755                 760                 765            
 Trp Gln Gln Leu Val Ser Arg Glu Val Leu Leu Gly Leu Lys Pro Cys
     770                 775                 780                
 Glu Ile Lys Arg Gln Glu Val Ile Asn Glu Leu Phe Tyr Thr Glu Arg
 785                 790                 795                 800
 Ala His Val Arg Thr Leu Lys Val Leu Asp Gln Val Phe Tyr Gln Arg
                 805                 810                 815    
 Val Ser Arg Glu Gly Ile Leu Ser Pro Ser Glu Leu Trp Lys Ile Phe
             820                 825                 830        
 Ser Asn Leu Glu Asp Ile Leu Gln Leu His Ile Gly Leu Asn Glu Gln
         835                 840                 845            
 Met Lys Ala Val Arg Lys Arg Asn Glu Thr Ser Val Ile Asp Gln Ile
     850                 855                 860                
 Gly Glu Asp Leu Leu Thr Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu
 865                 870                 875                 880
 Lys His Ala Ala Ala Thr Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu
                 885                 890                 895    
 Met Ile Lys Ser Arg Gln Lys Lys Asp Ser Arg Phe Gln Thr Phe Val
             900                 905                 910        
 Gln Asp Ala Glu Ser Asn Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp
         915                 920                 925            
 Ile Ile Pro Thr Gln Met Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu
     930                 935                 940                
 Asp Asn Ile Ala Lys Tyr Thr Glu Trp Pro Thr Glu Arg Glu Lys Val
 945                 950                 955                 960
 Lys Lys Ala Ala Asp His Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln
                 965                 970                 975    
 Ala Val Lys Glu Ala Glu Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg
             980                 985                 990        
 Arg Leu Asp Thr Ser Ser Leu Lys Leu Ser Glu Tyr Pro Asn Val Glu
         995                1000                1005            
 Glu Leu Arg Asn Leu Asp Leu Thr Lys Arg Lys Met Ile His Glu Gly
    1010                1015                1020                
 Pro Leu Val Trp Lys Val Asn Arg Asp Lys Thr Ile Asp Leu Tyr Thr
1025                1030                1035                1040
 Leu Leu Leu Glu Asp Ile Leu Val Leu Leu Gln Lys Gln Asp Asp Arg
                1045                1050                1055    
 Leu Val Leu Arg Cys His Ser Lys Ile Leu Ala Ser Thr Ala Asp Ser
            1060                1065                1070        
 Lys His Thr Phe Ser Pro Val Ile Lys Leu Ser Thr Val Leu Val Arg
        1075                1080                1085            
 Gln Gly Ala Thr Asp Asn Lys Ala Leu Phe Val Ile Ser Met Ser Asp
    1090                1095                1100                
 Asn Gly Ala Gln Ile Tyr Glu Leu Val Ala Gln Thr Val Ser Glu Lys
1105                1110                1115                1120
 Thr Val Trp Gln Asp Leu Ile Cys Arg Met Ala Ala Ser Val Lys Glu
                1125                1130                1135    
 Gln Ser Thr Lys Pro Ile Pro Leu Pro Gln Ser Thr Pro Gly Glu Gly
            1140                1145                1150        
 Asp Asn Asp Glu Glu Asp Pro Ser Lys Leu Lys Glu Glu Gln His Gly
        1155                1160                1165            
 Ile Ser Val Thr Gly Leu Gln Ser Pro Asp Arg Asp Leu Gly Leu Glu
    1170                1175                1180                
 Ser Thr Leu Ile Ser Ser Lys Pro Gln Ser His Ser Leu Ser Thr Ser
1185                1190                1195                1200
 Gly Lys Ser Glu Val Arg Asp Leu Phe Val Ala Glu Arg Gln Phe Ala
                1205                1210                1215    
 Lys Glu Gln His Thr Asp Gly Thr Leu Lys Glu Val Gly Glu Asp Tyr
            1220                1225                1230        
 Gln Ile Ala Ile Pro Asp Ser His Leu Pro Val Ser Glu Glu Arg Trp
        1235                1240                1245            
 Ala Leu Asp Ala Leu Arg Asn Leu Gly Leu Leu Lys Gln Leu Leu Val
    1250                1255                1260                
 Gln Gln Leu Gly Leu Thr Glu Lys Ser Val Gln Glu Asp Trp Gln His
1265                1270                1275                1280
 Phe Pro Arg Tyr Arg Thr Ala Ser Gln Gly Pro Gln Thr Asp Ser Val
                1285                1290                1295    
 Ile Gln Asn Ser Glu Asn Ile Lys Ala Tyr His Ser Gly Glu Gly His
            1300                1305                1310        
 Met Pro Phe Arg Thr Gly Thr Gly Asp Ile Ala Thr Cys Tyr Ser Pro
        1315                1320                1325            
 Arg Thr Ser Thr Glu Ser Phe Ala Pro Arg Asp Ser Val Gly Leu Ala
    1330                1335                1340                
 Pro Gln Asp Ser Gln Ala Ser Asn Ile Leu Val Met Asp His Met Ile
1345                1350                1355                1360
 Met Thr Pro Glu Met Pro Thr Met Glu Pro Glu Gly Gly Leu Asp Asp
                1365                1370                1375    
 Ser Gly Glu His Phe Phe Asp Ala Arg Glu Ala His Ser Asp Glu Asn
            1380                1385                1390        
 Pro Ser Glu Gly Asp Gly Ala Val Asn Lys Glu Glu Lys Asp Val Asn
        1395                1400                1405            
 Leu Arg Ile Ser Gly Asn Tyr Leu Ile Leu Asp Gly Tyr Asp Pro Val
    1410                1415                1420                
 Gln Glu Ser Ser Thr Asp Glu Glu Val Ala Ser Ser Leu Thr Leu Gln
1425                1430                1435                1440
 Pro Met Thr Gly Ile Pro Ala Val Glu Ser Thr His Gln Gln Gln His
                1445                1450                1455    
 Ser Pro Gln Asn Thr His Ser Asp Gly Ala Ile Ser Pro Phe Thr Pro
            1460                1465                1470        
 Glu Phe Leu Val Gln Gln Arg Trp Gly Ala Met Glu Tyr Ser Cys Phe
        1475                1480                1485            
 Glu Ile Gln Ser Pro Ser Ser Cys Ala Asp Ser Gln Ser Gln Ile Met
    1490                1495                1500                
 Glu Tyr Ile His Lys Ile Glu Ala Asp Leu Glu His Leu Lys Lys Val
1505                1510                1515                1520
 Glu Glu Ser Tyr Thr Ile Leu Cys Gln Arg Leu Ala Gly Ser Ala Leu
                1525                1530                1535    
 Thr Asp Lys His Ser Asp Lys Ser
            1540                



      <210> 134
      <211> 486
      <212> PRT
      <213> Homo sapiens


      <400> 134
 Met Met Gly Gln Asp Lys Ile Gln Gly His Ser Val Ile Ser Glu Glu
   1               5                  10                  15    
 Ser Asp Gly Lys Leu Ile Glu Asp Ser Leu Ile Gln Leu Arg Cys His
              20                  25                  30        
 Phe Thr Trp Lys Leu Leu Ile Glu Ala Pro Glu Ile Pro Asp Leu Glu
          35                  40                  45            
 Asn Arg Ile Trp Glu Glu Ile Gln Phe Leu Asp Thr Lys Tyr Asn Val
      50                  55                  60                
 Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu Lys Gly Gln Asn
  65                  70                  75                  80
 Glu Glu Ala Leu Val Ser Leu Lys Lys Ala Glu Asp Leu Ile Gln Lys
                  85                  90                  95    
 Glu His Ala Asn Gln Ala Asp Ile Arg Ser Leu Val Thr Trp Gly Asn
             100                 105                 110        
 Phe Ala Trp Val Tyr Tyr His Met Gly Arg Leu Ala Glu Ala Gln Thr
         115                 120                 125            
 Tyr Leu Asp Lys Val Glu Asn Thr Cys Lys Lys Phe Ala Asn Pro Ser
     130                 135                 140                
 Arg Tyr Arg Met Glu Cys Pro Glu Val Asp Cys Glu Glu Gly Trp Ala
 145                 150                 155                 160
 Leu Ala Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala Lys Thr Cys Phe
                 165                 170                 175    
 Glu Lys Ala Leu Glu Gly Asn Pro Glu Asn Pro Glu Phe Asn Thr Gly
             180                 185                 190        
 Tyr Ala Ile Thr Val Tyr Arg Leu Asp Lys Phe Asn Thr Ala Ser Gly
         195                 200                 205            
 Arg Asn Lys Ala Phe Ser Leu His Val Leu Lys Arg Ala Val Arg Leu
     210                 215                 220                
 Asn Pro Asp Asp Val Tyr Ile Arg Val Leu Leu Ala Leu Lys Leu Gln
 225                 230                 235                 240
 Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu Ala Leu
                 245                 250                 255    
 Thr Ser Ile Ser Ser Gln Ala Tyr Val Phe Gln Tyr Ala Ala Lys Phe
             260                 265                 270        
 Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu Leu Leu Lys Met
         275                 280                 285            
 Ala Leu Glu Thr Thr Pro Thr Ser Ala Phe Leu His His Gln Met Gly
     290                 295                 300                
 Leu Cys Tyr Arg Ala Gln Met Ile Gln Ile Lys Glu Ala Thr Asn Trp
 305                 310                 315                 320
 Gln Pro Arg Gly Gln Asp Arg Glu Thr Val Asp Arg Leu Val Gln Leu
                 325                 330                 335    
 Ala Ile Cys Lys Phe Glu Lys Thr Ile Met Leu Lys Arg Thr Phe Glu
             340                 345                 350        
 Met Ala Tyr Val Asp Leu Ala Glu Thr Tyr Ala Glu Ile Gly His His
         355                 360                 365            
 Arg Lys Ala Glu Glu His Phe Gln Lys Gly Leu Arg Met Lys Ile Phe
     370                 375                 380                
 Glu Asp Gln Leu Lys Gln Glu Ile His Tyr His Tyr Gly Arg Phe Gln
 385                 390                 395                 400
 Glu His His Gly Lys Ser Gln Asp Lys Ala Ile Thr His Tyr Leu Lys
                 405                 410                 415    
 Gly Leu Lys Ile Glu Lys Met Ser His Ser Arg Glu Lys Leu Leu Asn
             420                 425                 430        
 Ala Leu Glu Lys Leu Ala Lys Arg Cys Ile His Gln Asn Val Arg Val
         435                 440                 445            
 Val Glu Ser Val Ser Leu Leu Gly Leu Ile His Lys Leu Lys Gly Glu
     450                 455                 460                
 Val Ser Asp Ala Leu Leu Cys Tyr Glu Arg Ala Leu Arg Leu Ala Ala
 465                 470                 475                 480
 Asp Leu Asn Pro Ile Phe
                 485    



      <210> 135
      <211> 403
      <212> PRT
      <213> Homo sapiens


      <400> 135
 Met Glu Thr Tyr Ala Glu Val Gly Lys Glu Gly Lys Pro Ser Cys Ala
   1               5                  10                  15    
 Ser Val Asp Leu Gln Gly Asp Ser Ser Leu Gln Val Glu Ile Ser Asp
              20                  25                  30        
 Ala Val Ser Glu Arg Asp Lys Val Lys Phe Thr Val Gln Thr Lys Ser
          35                  40                  45            
 Cys Leu Pro His Phe Ala Gln Thr Glu Phe Ser Val Val Arg Gln His
      50                  55                  60                
 Glu Glu Phe Ile Trp Leu His Asp Ala Tyr Val Glu Asn Glu Glu Tyr
  65                  70                  75                  80
 Ala Gly Leu Ile Ile Pro Pro Ala Pro Pro Arg Pro Asp Phe Glu Ala
                  85                  90                  95    
 Ser Arg Glu Lys Leu Gln Lys Leu Gly Glu Gly Asp Ser Ser Val Thr
             100                 105                 110        
 Arg Glu Glu Phe Ala Lys Met Lys Gln Glu Leu Glu Ala Glu Tyr Leu
         115                 120                 125            
 Ala Ile Phe Lys Lys Thr Val Ala Met His Glu Val Phe Leu Gln Arg
     130                 135                 140                
 Leu Ala Ala His Pro Thr Leu Arg Arg Asp His Asn Phe Phe Val Phe
 145                 150                 155                 160
 Leu Glu Tyr Gly Gln Asp Leu Ser Val Arg Gly Lys Asn Arg Lys Glu
                 165                 170                 175    
 Leu Leu Gly Gly Phe Leu Arg Asn Ile Val Lys Ser Ala Asp Glu Ala
             180                 185                 190        
 Leu Ile Thr Gly Met Ser Gly Leu Lys Glu Val Asp Asp Phe Phe Glu
         195                 200                 205            
 His Glu Arg Thr Phe Leu Leu Glu Tyr His Thr Arg Ile Arg Asp Ala
     210                 215                 220                
 Cys Leu Arg Ala Asp Arg Val Met Arg Ala His Lys Cys Leu Ala Asp
 225                 230                 235                 240
 Asp Tyr Ile Pro Ile Ser Ala Ala Leu Ser Ser Leu Gly Thr Gln Glu
                 245                 250                 255    
 Val Asn Gln Leu Arg Thr Ser Phe Leu Lys Leu Ala Glu Leu Phe Glu
             260                 265                 270        
 Arg Leu Arg Lys Leu Glu Gly Arg Val Ala Ser Asp Glu Asp Leu Lys
         275                 280                 285            
 Leu Ser Asp Met Leu Arg Tyr Tyr Met Arg Asp Ser Gln Ala Ala Lys
     290                 295                 300                
 Asp Leu Leu Tyr Arg Arg Leu Arg Ala Leu Ala Asp Tyr Glu Asn Ala
 305                 310                 315                 320
 Asn Lys Ala Leu Asp Lys Ala Arg Thr Arg Asn Arg Glu Val Arg Pro
                 325                 330                 335    
 Ala Glu Ser His Gln Gln Leu Cys Cys Gln Arg Phe Glu Arg Leu Ser
             340                 345                 350        
 Asp Ser Ala Lys Gln Glu Leu Met Asp Phe Lys Ser Arg Arg Val Ser
         355                 360                 365            
 Ser Phe Arg Lys Asn Leu Ile Glu Leu Ala Glu Leu Glu Leu Lys His
     370                 375                 380                
 Ala Lys Ala Ser Thr Leu Ile Leu Arg Asn Thr Leu Val Ala Leu Lys
 385                 390                 395                 400
 Gly Glu Pro
            



      <210> 136
      <211> 273
      <212> PRT
      <213> Homo sapiens


      <400> 136
 Met Thr Leu Ser Pro Leu Leu Leu Phe Leu Pro Pro Leu Leu Leu Leu
   1               5                  10                  15    
 Leu Asp Val Pro Thr Ala Ala Val Gln Ala Ser Pro Leu Gln Ala Leu
              20                  25                  30        
 Asp Phe Phe Gly Asn Gly Pro Pro Val Asn Tyr Lys Thr Gly Asn Leu
          35                  40                  45            
 Tyr Leu Arg Gly Pro Leu Lys Lys Ser Asn Ala Pro Leu Val Asn Val
      50                  55                  60                
 Thr Leu Tyr Tyr Glu Ala Leu Cys Gly Gly Cys Arg Ala Phe Leu Ile
  65                  70                  75                  80
 Arg Glu Leu Phe Pro Thr Trp Leu Leu Val Met Glu Ile Leu Asn Val
                  85                  90                  95    
 Thr Leu Val Pro Tyr Gly Asn Ala Gln Glu Gln Asn Val Ser Gly Arg
             100                 105                 110        
 Trp Glu Phe Lys Cys Gln His Gly Glu Glu Glu Cys Lys Phe Asn Lys
         115                 120                 125            
 Val Glu Ala Cys Val Leu Asp Glu Leu Asp Met Glu Leu Ala Phe Leu
     130                 135                 140                
 Thr Ile Val Cys Met Glu Glu Phe Glu Asp Met Glu Arg Ser Leu Pro
 145                 150                 155                 160
 Leu Cys Leu Gln Leu Tyr Ala Pro Gly Leu Ser Pro Asp Thr Ile Met
                 165                 170                 175    
 Glu Cys Ala Met Gly Asp Arg Gly Met Gln Leu Met His Ala Asn Ala
             180                 185                 190        
 Gln Arg Thr Asp Ala Leu Gln Pro Pro His Glu Tyr Val Pro Trp Val
         195                 200                 205            
 Thr Val Asn Gly Lys Pro Leu Gly Arg Ser Asp Pro Ala Pro Tyr Pro
     210                 215                 220                
 Cys Leu Pro Val Val Pro Gly Gln Glu Ala Gly Cys Leu Pro Phe Leu
 225                 230                 235                 240
 Asn Gln Leu Pro Gln Glu Cys Leu Leu Gln Val Met Ala Gly Glu Leu
                 245                 250                 255    
 Arg Arg Ala His Gly Arg Arg Val Gly Thr Arg Leu Pro Ala Phe Phe
             260                 265                 270        
 Phe
    



      <210> 137
      <211> 806
      <212> PRT
      <213> Homo sapiens


      <400> 137
 Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val
   1               5                  10                  15    
 Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met
              20                  25                  30        
 Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg
          35                  40                  45            
 Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser
      50                  55                  60                
 Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala
  65                  70                  75                  80
 Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala
                  85                  90                  95    
 Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly
             100                 105                 110        
 Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala
         115                 120                 125            
 Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser
     130                 135                 140                
 Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Val Gln Thr Cys Leu
 145                 150                 155                 160
 Glu Pro Gly Gly Arg Gly Pro Ser Gly Glu Arg Ser Val Ala Gly Asp
                 165                 170                 175    
 Leu Arg Ser Leu Gly Asp Arg Gly Ser Val Arg Arg Glu Gly Lys Val
             180                 185                 190        
 Ala Ser Trp Leu Gly Ser Ser Pro Arg Ser Arg Gly Glu Leu Leu Pro
         195                 200                 205            
 Gly Arg Arg Pro Ser Ser Pro Ser Ser His Gly Gln Met Leu Thr Pro
     210                 215                 220                
 Lys Ile Asn Lys Leu Glu Lys Ala Val Ala Ala Ala His Thr Phe Phe
 225                 230                 235                 240
 Val Gly Asn Pro Glu His Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr
                 245                 250                 255    
 Gln Thr Met Ser Gly Val Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr
             260                 265                 270        
 Gln Pro His Met Gln Glu Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu
         275                 280                 285            
 Glu Gln Pro Gln Glu Ala Val Pro His Leu Glu Ala Ala Leu Gln Glu
     290                 295                 300                
 Tyr Phe Val Ala Tyr Glu Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr
 305                 310                 315                 320
 Asp Tyr Asp Gly Tyr Asn Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln
                 325                 330                 335    
 Ala Ile Thr Asp His Tyr Ile Gln Val Leu Asn Cys Lys Gln Asn Cys
             340                 345                 350        
 Val Thr Glu Leu Ala Ser His Pro Ser Arg Glu Lys Pro Phe Glu Asp
         355                 360                 365            
 Phe Leu Pro Ser His Tyr Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile
     370                 375                 380                
 Gly Asn Tyr Thr Gln Ala Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe
 385                 390                 395                 400
 Phe Pro Asn Asp Glu Val Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala
                 405                 410                 415    
 Met Leu Gly Glu Glu His Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala
             420                 425                 430        
 Lys Glu Tyr Arg Gln Arg Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe
         435                 440                 445            
 Ala Tyr Asp Val Phe Gly Ile Pro Phe Val Asp Pro Asp Ser Trp Thr
     450                 455                 460                
 Pro Glu Glu Val Ile Pro Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu
 465                 470                 475                 480
 Arg Glu Thr Ala Val Arg Ile Ser Gln Glu Ile Gly Asn Leu Met Lys
                 485                 490                 495    
 Glu Ile Glu Thr Leu Val Glu Glu Lys Thr Lys Glu Ser Leu Asp Val
             500                 505                 510        
 Ser Arg Leu Thr Arg Glu Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser
         515                 520                 525            
 Leu Thr Met Asn Ser Lys Leu Leu Asn Gly Ser Gln Arg Val Val Met
     530                 535                 540                
 Asp Gly Val Ile Ser Asp His Glu Cys Gln Glu Leu Gln Arg Leu Thr
 545                 550                 555                 560
 Asn Val Ala Ala Thr Ser Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro
                 565                 570                 575    
 His Thr Pro Asn Glu Lys Phe Tyr Gly Val Thr Val Phe Lys Ala Leu
             580                 585                 590        
 Lys Leu Gly Gln Glu Gly Lys Val Pro Leu Gln Ser Ala His Leu Tyr
         595                 600                 605            
 Tyr Asn Val Thr Glu Lys Val Arg Arg Ile Met Glu Ser Tyr Phe Arg
     610                 615                 620                
 Leu Asp Thr Pro Leu Tyr Phe Ser Tyr Ser His Leu Val Cys Arg Thr
 625                 630                 635                 640
 Ala Ile Glu Glu Val Gln Ala Glu Arg Lys Asp Asp Ser His Pro Val
                 645                 650                 655    
 His Val Asp Asn Cys Ile Leu Asn Ala Glu Thr Leu Val Cys Val Lys
             660                 665                 670        
 Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu
         675                 680                 685            
 Asn Gly Asp Phe Asp Gly Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala
     690                 695                 700                
 Lys Thr Val Thr Ala Glu Val Gln Pro Gln Cys Gly Arg Ala Val Gly
 705                 710                 715                 720
 Phe Ser Ser Gly Thr Glu Asn Pro His Gly Val Lys Ala Val Thr Arg
                 725                 730                 735    
 Gly Gln Arg Cys Ala Ile Ala Leu Trp Phe Thr Leu Asp Pro Arg His
             740                 745                 750        
 Ser Glu Arg Asp Arg Val Gln Ala Asp Asp Leu Val Lys Met Leu Phe
         755                 760                 765            
 Ser Pro Glu Glu Met Asp Leu Ser Gln Glu Gln Pro Leu Asp Ala Gln
     770                 775                 780                
 Gln Gly Pro Pro Glu Pro Ala Gln Glu Ser Leu Ser Gly Ser Glu Ser
 785                 790                 795                 800
 Lys Pro Lys Asp Glu Leu
                 805    



      <210> 138
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 138
 Met Arg Phe Val Leu Cys Val Lys Ala Lys Pro Ser Gly Leu Val Thr
   1               5                  10                  15    
 Ile Ser Arg Lys Ile Thr Gln Asp Tyr Gly Gln Asp Ala Ala Phe Thr
              20                  25                  30        
 Ala Ile Leu Asp Thr Leu Asp Ile Phe Leu Glu Ile Val Thr Asn Pro
          35                  40                  45            
 Asp Gly Phe Ala Phe Thr His Ser Thr Asn Arg Met Trp Arg Lys Thr
      50                  55                  60                
 Arg Ser His Thr Ala Gly Ser Leu Cys Ile Gly Val Asp Pro Asn Arg
  65                  70                  75                  80
 Asn Trp Asp Ala Gly Phe Gly Leu Ser Gly Ala Ser Ser Asn Pro Cys
                  85                  90                  95    
 Ser Glu Thr Tyr His Gly Lys Phe Ala Asn Ser Glu Val Glu Val Lys
             100                 105                 110        
 Ser Ile Val Asp Phe Val Lys Asp His Gly Asn Ile Lys Ala Phe Ile
         115                 120                 125            
 Ser Ile His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr Lys
     130                 135                 140                
 Thr Glu Pro Val Pro Asp Gln Asp Glu Leu Asp Gln Leu Ser Lys Ala
 145                 150                 155                 160
 Ala Val Thr Ala Leu Ala Ser Leu Tyr Gly Thr Lys Phe Asn Tyr Gly
                 165                 170                 175    
 Ser Ile Ile Lys Ala Ile Tyr Gln Ala Ser Gly Ser Thr Ile Asp Trp
             180                 185                 190        
 Thr Tyr Ser Gln Gly Ile Lys Tyr Ser Phe Thr Phe Glu Leu Arg Asp
         195                 200                 205            
 Thr Gly Arg Tyr Gly Phe Leu Leu Pro Ala Ser Gln Ile Ile Pro Thr
     210                 215                 220                
 Ala Lys Glu Thr Trp Leu Ala Leu Leu Thr Ile Met Glu His Thr Leu
 225                 230                 235                 240
 Asn His Pro Tyr
                



      <210> 139
      <211> 538
      <212> PRT
      <213> Homo sapiens


      <400> 139
 Met Ala Leu Tyr Asp Glu Asp Leu Leu Lys Asn Pro Phe Tyr Leu Ala
   1               5                  10                  15    
 Leu Gln Lys Cys Arg Pro Asp Leu Cys Ser Lys Val Ala Gln Ile His
              20                  25                  30        
 Gly Ile Val Leu Val Pro Cys Lys Gly Ser Leu Ser Ser Ser Ile Gln
          35                  40                  45            
 Ser Thr Cys Gln Phe Glu Ser Tyr Ile Leu Ile Pro Val Glu Glu His
      50                  55                  60                
 Phe Gln Thr Leu Asn Gly Lys Asp Val Phe Ile Gln Gly Asn Arg Ile
  65                  70                  75                  80
 Lys Leu Gly Ala Gly Phe Ala Cys Leu Leu Ser Val Pro Ile Leu Phe
                  85                  90                  95    
 Glu Glu Thr Phe Tyr Asn Glu Lys Glu Glu Ser Phe Ser Ile Leu Cys
             100                 105                 110        
 Ile Ala His Pro Leu Glu Lys Arg Glu Ser Ser Glu Glu Pro Leu Ala
         115                 120                 125            
 Pro Ser Asp Pro Phe Ser Leu Lys Thr Ile Glu Asp Val Arg Glu Phe
     130                 135                 140                
 Leu Gly Arg His Ser Glu Arg Phe Asp Arg Asn Ile Ala Ser Phe His
 145                 150                 155                 160
 Arg Thr Phe Arg Glu Cys Glu Arg Lys Ser Leu Arg His His Ile Asp
                 165                 170                 175    
 Ser Ala Asn Ala Leu Tyr Thr Lys Cys Leu Gln Gln Leu Leu Arg Asp
             180                 185                 190        
 Ser His Leu Lys Met Leu Ala Lys Gln Glu Ala Gln Met Asn Leu Met
         195                 200                 205            
 Lys Gln Ala Val Glu Ile Tyr Val His His Glu Ile Tyr Asn Leu Ile
     210                 215                 220                
 Phe Lys Tyr Val Gly Thr Met Glu Ala Ser Glu Asp Ala Ala Phe Asn
 225                 230                 235                 240
 Lys Ile Thr Arg Ser Leu Gln Asp Leu Gln Gln Lys Asp Ile Gly Val
                 245                 250                 255    
 Lys Pro Glu Phe Ser Phe Asn Ile Pro Arg Ala Lys Arg Glu Leu Ala
             260                 265                 270        
 Gln Leu Asn Lys Cys Thr Ser Pro Gln Gln Lys Leu Val Cys Leu Arg
         275                 280                 285            
 Lys Val Val Gln Leu Ile Thr Gln Ser Pro Ser Gln Arg Val Asn Leu
     290                 295                 300                
 Glu Thr Met Cys Ala Asp Asp Leu Leu Ser Val Leu Leu Tyr Leu Leu
 305                 310                 315                 320
 Val Lys Thr Glu Ile Pro Asn Trp Met Ala Asn Leu Ser Tyr Ile Lys
                 325                 330                 335    
 Asn Phe Arg Phe Ser Ser Leu Ala Lys Asp Glu Leu Gly Tyr Cys Leu
             340                 345                 350        
 Thr Ser Phe Glu Ala Ala Ile Glu Tyr Ile Arg Gln Gly Ser Leu Ser
         355                 360                 365            
 Ala Lys Pro Pro Glu Ser Glu Gly Phe Gly Asp Arg Leu Phe Leu Lys
     370                 375                 380                
 Gln Arg Met Ser Leu Leu Ser Gln Met Thr Ser Ser Pro Thr Asp Cys
 385                 390                 395                 400
 Leu Phe Lys His Ile Ala Ser Gly Asn Gln Lys Glu Val Glu Arg Leu
                 405                 410                 415    
 Leu Ser Gln Glu Asp His Asp Lys Asp Thr Val Gln Lys Met Cys His
             420                 425                 430        
 Pro Leu Cys Phe Cys Asp Asp Cys Glu Lys Leu Val Ser Gly Arg Leu
         435                 440                 445            
 Asn Asp Pro Ser Val Val Thr Pro Phe Ser Arg Asp Asp Arg Gly His
     450                 455                 460                
 Thr Pro Leu His Val Ala Ala Val Cys Gly Gln Ala Ser Leu Ile Asp
 465                 470                 475                 480
 Leu Leu Val Ser Lys Gly Ala Met Val Asn Ala Thr Asp Tyr His Gly
                 485                 490                 495    
 Ala Thr Pro Leu His Leu Ala Cys Gln Lys Gly Tyr Gln Ser Val Thr
             500                 505                 510        
 Leu Leu Leu Leu His Tyr Lys Ala Ser Ala Glu Val Gln Asp Asn Asn
         515                 520                 525            
 Gly Asn Thr Pro His Val Leu Arg Pro Leu
     530                 535            



      <210> 140
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 140
 Met Ala Thr Gly Ile Arg Leu Pro Ala Leu Pro Ala Ser Pro Arg Val
   1               5                  10                  15    
 Pro Ser Glu Gly Pro Gly Phe Ser Glu His Pro Glu Gly Pro Pro Ala
              20                  25                  30        
 Leu Pro Pro Ala Ile Pro Phe Ser Phe Thr Leu Leu Val Gln Ala Val
          35                  40                  45            
 Phe Phe Leu Tyr Gln Ala Trp Trp Leu Leu His Gly Ala Pro Gln Gly
      50                  55                  60                
 Lys Gly Trp Pro Gln Ala Ser Gly Leu Glu Asp Arg Val Thr Arg Glu
  65                  70                  75                  80
 Glu Gly Ser Pro Arg Gly Pro Ser Ile Ser Leu Asn Cys Gly Cys Pro
                  85                  90                  95    
 Ala Trp Val Pro Cys Glu Arg Pro Ala Cys Val Gly Trp Gly Gly Pro
             100                 105                 110        
 Pro Gln Pro Pro Gly Ala Ile Cys Glu Ala Thr Ala Pro Pro Ser Ile
         115                 120                 125            
 Phe Leu Pro Phe Pro Phe Gln Pro Leu Phe Gln Glu Pro Cys His Thr
     130                 135                 140                
 His Thr Cys Ser Leu Pro Ser Pro Ala Leu Pro Pro Leu Leu Arg Arg
 145                 150                 155                 160
 Gly Arg Pro Arg Pro Cys Ala Ala Leu Ala Leu Pro Ala Leu Ser Ser
                 165                 170                 175    
 Leu Phe Ser Pro Val Phe Ser Leu Leu Ser Leu Gln Leu Pro Ala Asp
             180                 185                 190        
 Arg Val Arg Gln Val His Pro Val Leu Arg Ala Pro Gly Pro Pro Ser
         195                 200                 205            
 Thr Ser Lys Gln Ile Pro Pro Leu Leu Gly Asp Leu Pro Phe Gln Ala
     210                 215                 220                
 Cys Leu Asp Gly Cys Ser Val Thr
 225                 230        



      <210> 141
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 141
 Met Thr Ser Ile Ile Lys Leu Thr Thr Leu Ser Gly Val Gln Glu Glu
   1               5                  10                  15    
 Ser Ala Leu Cys Tyr Leu Leu Gln Val Asp Glu Phe Arg Phe Leu Leu
              20                  25                  30        
 Asp Cys Gly Trp Asp Glu His Phe Ser Met Asp Ile Ile Asp Ser Leu
          35                  40                  45            
 Arg Lys His Val His Gln Ile Asp Ala Val Leu Leu Ser His Pro Asp
      50                  55                  60                
 Pro Leu His Leu Gly Ala Leu Pro Tyr Ala Val Gly Lys Leu Gly Leu
  65                  70                  75                  80
 Asn Cys Ala Ile Tyr Ala Thr Ile Pro Val Tyr Lys Met Gly Gln Met
                  85                  90                  95    
 Phe Met Tyr Asp Leu Tyr Gln Val Ile
             100                 105



      <210> 142
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 142
 Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
   1               5                  10                  15    
 Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp
              20                  25                  30        
 Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg
          35                  40                  45            
 Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly
      50                  55                  60                
 Glu Tyr Ser Gln Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
  65                  70                  75                  80
 Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                  85                  90                  95    
 Tyr Gln Lys His Arg Lys Gly Lys Gln Phe Gln Glu Arg Leu Leu Leu
             100                 105                 110        
 Glu Ile Pro Thr Ser Val Asp Trp Arg Glu Lys Gly Tyr Met Thr Pro
         115                 120                 125            
 Val Lys Asp Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
     130                 135                 140                
 Gly Ala Leu Glu Gly Gln Met Phe Trp Lys Thr Gly Lys Leu Ile Ser
 145                 150                 155                 160
 Leu Asn Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                 165                 170                 175    
 Gly Cys Asn Gly Asp Phe Met Asp Asn Pro Phe Arg Tyr Val Gln Glu
             180                 185                 190        
 Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
         195                 200                 205            
 Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
     210                 215                 220                
 Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
 225                 230                 235                 240
 Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                 245                 250                 255    
 Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
             260                 265                 270        
 Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
         275                 280                 285            
 Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
     290                 295                 300                
 Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
 305                 310                 315                 320
 His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                 325                 330            



      <210> 143
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 143
 Met Leu Gly Cys Gln Gly Arg Met Tyr Thr Leu Leu Ser Gly Leu Tyr
   1               5                  10                  15    
 Lys Tyr Met Phe Gln Lys Asp Glu Tyr Cys Ile Leu Ile Leu Gly Leu
              20                  25                  30        
 Asp Asn Ala Gly Lys Thr Thr Phe Leu Glu Gln Ser Lys Thr Arg Phe
          35                  40                  45            
 Asn Lys Asn Tyr Lys Gly Met Ser Leu Ser Lys Ile Thr Thr Thr Val
      50                  55                  60                
 Gly Leu Asn Ile Gly Thr Val Asp Val Gly Lys Ala Arg Leu Met Phe
  65                  70                  75                  80
 Trp Asp Leu Gly Gly Gln Glu Glu Leu Gln Ser Leu Trp Asp Lys Tyr
                  85                  90                  95    
 Tyr Ala Glu Cys His Gly Val Ile Tyr Val Ile Asp Ser Thr Asp Glu
             100                 105                 110        
 Glu Arg Leu Ala Glu Ser Lys Gln Ala Phe Glu Lys Val Val Thr Ser
         115                 120                 125            
 Glu Ala Leu Cys Gly Val Pro Val Leu Val Leu Ala Asn Lys Gln Asp
     130                 135                 140                
 Val Glu Thr Cys Leu Ser Ile Pro Asp Ile Lys Thr Ala Phe Ser Asp
 145                 150                 155                 160
 Cys Thr Ser Lys Ile Gly Arg Arg Asp Cys Leu Thr Gln Ala Cys Ser
                 165                 170                 175    
 Ala Leu Thr Gly Lys Gly Val Arg Glu Gly Ile Glu Trp Met Val Lys
             180                 185                 190        
 Cys Val Val Arg Asn Val His Arg Pro Pro Arg Gln Arg Asp Ile Thr
         195                 200                 205            





      <210> 144
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 144
 Met Leu Ser Val Asp Ile Thr Ser Arg Tyr Arg Ala Pro Ser Thr Tyr
   1               5                  10                  15    
 Leu Leu Asn Ser Leu Lys Glu Gly Leu Glu Gly Leu His Gly Glu Ser
              20                  25                  30        
 Cys Ser Ser Phe Leu Leu Gly Pro Ser Val Ala Met Asn Met Gln Thr
          35                  40                  45            
 Ala Gly Leu Glu Met Asp Ile Cys Asp Gly His Phe Arg Gln Asn Gly
      50                  55                  60                
 Gly Cys Gly Tyr Val Leu Lys Pro Asp Phe Leu Arg Asp Ile Gln Ser
  65                  70                  75                  80
 Ser Phe His Pro Glu Lys Pro Ile Ser Pro Phe Lys Ala Gln Thr Leu
                  85                  90                  95    
 Leu Ile Gln Val Ile Ser Gly Gln Gln Leu Pro Lys Val Asp Lys Thr
             100                 105                 110        
 Lys Glu Gly Ser Ile Val Asp Pro Leu Val Lys Val Gln Ile Phe Gly
         115                 120                 125            
 Val Arg Leu Asp Thr Ala Arg Gln Glu Thr Asn Tyr Val Glu Asn Asn
     130                 135                 140                
 Gly Phe Asn Pro Tyr Trp Gly Gln Thr Leu Cys Phe Arg Val Leu Val
 145                 150                 155                 160
 Pro Glu Leu Ala Met Leu Arg Phe Val Val Met Asp Tyr Asp Trp Lys
                 165                 170                 175    
 Ser Arg Asn Asp Phe Ile Gly Gln Tyr Thr Leu Pro Trp Thr Cys Met
             180                 185                 190        
 Gln Gln Gly Tyr Arg His Ile His Leu Leu Ser Lys Asp Gly Ile Ser
         195                 200                 205            
 Leu Arg Pro Ala Ser Ile Phe Val Tyr Ile Cys Ile Gln Glu Gly Leu
     210                 215                 220                
 Glu Gly Asp Glu Ser
 225                



      <210> 145
      <211> 223
      <212> PRT
      <213> Homo sapiens


      <400> 145
 Met Arg Gly Pro Gly Gln Ala Asp Cys Ala Val Ala Ile Gly Arg Pro
   1               5                  10                  15    
 Leu Gly Glu Val Val Thr Leu Arg Val Leu Glu Ser Ser Leu Asn Cys
              20                  25                  30        
 Ser Ala Gly Asp Met Leu Leu Leu Trp Gly Arg Leu Thr Trp Arg Lys
          35                  40                  45            
 Met Cys Arg Lys Leu Leu Asp Met Thr Phe Ser Ser Lys Thr Asn Thr
      50                  55                  60                
 Leu Val Val Arg Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu
  65                  70                  75                  80
 Arg Tyr Gly Ser Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu Cys Asp
                  85                  90                  95    
 Met Gln Leu Phe Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu Ser
             100                 105                 110        
 Pro Ala Thr Ser Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn Val Ala
         115                 120                 125            
 Pro His Ala Arg Ile Ala Ile His Ala Leu Ala Thr Asn Met Gly Ala
     130                 135                 140                
 Gly Thr Glu Gly Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp Thr His
 145                 150                 155                 160
 Ser Leu Arg Thr Thr Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu
                 165                 170                 175    
 Ser Glu Ser Ser Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys
             180                 185                 190        
 Ala Gln Ala Ser Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser Trp Val
         195                 200                 205            
 Pro Glu Met Gln Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Thr
     210                 215                 220            



      <210> 146
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 146
 Met Thr Asp Pro Asp Gly Asn Pro Lys Cys Leu Thr Lys Ile Asn Tyr
   1               5                  10                  15    
 Gly Gly Glu Val Pro Lys Ser Tyr Tyr Leu Cys Lys Gln Val Arg Leu
              20                  25                  30        
 Gln Tyr Glu His Thr Arg Ser Val Gly Arg Gly Ser Ser Leu Gln Val
          35                  40                  45            
 Glu Asn Glu Ile Leu Phe Pro Gly Cys Val Leu Arg Cys Pro Glu Val
      50                  55                  60                
 Leu Gln His Leu Gln Pro Gly Ser Phe
  65                  70            



      <210> 147
      <211> 202
      <212> PRT
      <213> Homo sapiens


      <400> 147
 Met Ala Glu Tyr Leu Ala Ser Ile Phe Gly Thr Glu Lys Asp Lys Val
   1               5                  10                  15    
 Asn Cys Ser Phe Tyr Phe Lys Ile Gly Val Cys Arg His Gly Asp Arg
              20                  25                  30        
 Cys Ser Arg Leu His Asn Lys Pro Thr Phe Ser Gln Glu Val Phe Thr
          35                  40                  45            
 Glu Leu Gln Glu Lys Tyr Gly Glu Ile Glu Glu Met Asn Val Cys Asp
      50                  55                  60                
 Asn Leu Gly Asp His Leu Val Gly Asn Val Tyr Val Lys Phe Arg Arg
  65                  70                  75                  80
 Glu Glu Asp Gly Glu Arg Ala Val Ala Glu Leu Ser Asn Arg Trp Phe
                  85                  90                  95    
 Asn Gly Gln Ala Val His Gly Asn Val Pro Glu Val Ala Ser Ala Thr
             100                 105                 110        
 Ser Cys Ile Cys Gly Pro Phe Pro Arg Thr Ser Arg Gly Ser Ser Met
         115                 120                 125            
 Gly Gly Asp Pro Gly Ala Gly His Pro Arg Gly Ser Ile Leu Ala Thr
     130                 135                 140                
 Ile Pro Glu Arg Gly Thr Ile Gly Val Pro Leu Ile Thr Gly Met Ala
 145                 150                 155                 160
 Ala Ser Glu Ala Leu Ala Pro Leu Pro Phe Thr Pro Asn Arg Asp Arg
                 165                 170                 175    
 Cys Ser Trp Gln Asp Leu Ser Ser Lys Pro Pro Ser Leu Ser Cys Pro
             180                 185                 190        
 Ile Leu Pro Arg Leu Pro Gly Ser Ile Met
         195                 200        



      <210> 148
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 148
 Met Ala Glu Tyr Leu Ala Ser Ile Phe Gly Thr Glu Lys Asp Lys Val
   1               5                  10                  15    
 Asn Cys Ser Phe Tyr Phe Lys Ile Gly Ala Cys Arg His Gly Asp Arg
              20                  25                  30        
 Cys Ser Arg Leu His Asn Lys Pro Thr Phe Ser Gln Thr Ile Val Leu
          35                  40                  45            
 Leu Asn Leu Tyr Arg Asn Pro Gln Asn Thr Ala Gln Thr Ala Asp Gly
      50                  55                  60                
 Ser His Cys His Val Ser Asp Val Glu Val Gln Glu His Tyr Asp Ser
  65                  70                  75                  80
 Phe Phe Glu Glu Val Phe Thr Glu Leu Gln Glu Lys Tyr Gly Glu Ile
                  85                  90                  95    
 Glu Glu Met Asn Val Cys Asp Asn Leu Gly Asp His Leu Val Gly Asn
             100                 105                 110        
 Val Tyr Val Lys Phe Arg Arg Glu Glu Asp Gly Glu Arg Ala Val Ala
         115                 120                 125            
 Glu Leu Ser Asn Arg Trp Phe Asn Gly Gln Ala Val His Gly Asn Val
     130                 135                 140                
 Pro Glu Val Ala Ser Ala Thr Ser Cys Ile Cys Gly Pro Phe Pro Arg
 145                 150                 155                 160
 Thr Ser Arg Gly Ser Ser Met Gly Gly Asp Pro Gly Ala Gly His Pro
                 165                 170                 175    
 Arg Gly Ser Ile Leu Ala Thr Ile Pro Glu Arg Gly Thr Ile Val Val
             180                 185                 190        
 Pro Leu Ile Thr Gly Met Ala Ala Ser Glu Ala Leu Ala Pro Leu Pro
         195                 200                 205            
 Phe Thr Pro Asn Arg Asp Arg Cys Ser Trp Gln Asp Leu Ser Ser Lys
     210                 215                 220                
 Pro Pro Ser Leu Ser Cys Pro Ile Leu Pro Arg Leu Pro Gly Ser Ile
 225                 230                 235                 240
 Met
    



      <210> 149
      <211> 794
      <212> PRT
      <213> Homo sapiens


      <400> 149
 Met Leu Cys Gly Arg Trp Arg Arg Cys Arg Arg Pro Pro Glu Glu Pro
   1               5                  10                  15    
 Pro Val Ala Ala Gln Val Ala Ala Gln Val Ala Ala Pro Val Ala Leu
              20                  25                  30        
 Pro Ser Pro Pro Thr Pro Ser Asp Gly Gly Thr Lys Arg Pro Gly Leu
          35                  40                  45            
 Arg Ala Leu Lys Lys Met Gly Leu Thr Glu Asp Glu Asp Val Arg Ala
      50                  55                  60                
 Met Leu Arg Gly Ser Arg Leu Arg Lys Ile Arg Ser Arg Thr Trp His
  65                  70                  75                  80
 Lys Glu Arg Leu Tyr Arg Leu Gln Glu Asp Gly Leu Ser Val Trp Phe
                  85                  90                  95    
 Gln Arg Arg Ile Pro Arg Ala Pro Ser Gln His Ile Phe Phe Val Gln
             100                 105                 110        
 His Ile Glu Ala Val Arg Glu Gly His Gln Ser Glu Gly Leu Arg Arg
         115                 120                 125            
 Phe Gly Gly Ala Phe Ala Pro Ala Arg Cys Leu Thr Ile Ala Phe Lys
     130                 135                 140                
 Gly Arg Arg Lys Asn Leu Asp Leu Ala Ala Pro Thr Ala Glu Glu Ala
 145                 150                 155                 160
 Gln Arg Trp Val Arg Gly Leu Thr Lys Leu Arg Ala Arg Leu Asp Ala
                 165                 170                 175    
 Met Ser Gln Arg Glu Arg Leu Asp His Trp Ile His Ser Tyr Leu His
             180                 185                 190        
 Arg Ala Asp Ser Asn Gln Asp Ser Lys Met Ser Phe Lys Glu Ile Lys
         195                 200                 205            
 Ser Leu Leu Arg Met Val Asn Val Asp Met Asn Asp Met Tyr Ala Tyr
     210                 215                 220                
 Leu Leu Phe Lys Glu Cys Asp His Ser Asn Asn Asp Arg Leu Glu Gly
 225                 230                 235                 240
 Ala Glu Ile Glu Glu Phe Leu Arg Arg Leu Leu Lys Arg Pro Glu Leu
                 245                 250                 255    
 Glu Glu Ile Phe His Gln Tyr Ser Gly Glu Asp Arg Val Leu Ser Ala
             260                 265                 270        
 Pro Glu Leu Leu Glu Phe Leu Glu Asp Gln Gly Glu Glu Gly Ala Thr
         275                 280                 285            
 Leu Ala Arg Ala Gln Gln Leu Ile Gln Thr Tyr Glu Leu Asn Glu Thr
     290                 295                 300                
 Ala Lys Gln His Glu Leu Met Thr Leu Asp Gly Phe Met Met Tyr Leu
 305                 310                 315                 320
 Leu Ser Pro Glu Gly Ala Ala Leu Asp Asn Thr His Thr Cys Val Phe
                 325                 330                 335    
 Gln Asp Met Asn Gln Pro Leu Ala His Tyr Phe Ile Ser Ser Ser His
             340                 345                 350        
 Asn Thr Tyr Leu Thr Asp Ser Gln Ile Gly Gly Pro Ser Ser Thr Glu
         355                 360                 365            
 Ala Tyr Val Arg Tyr Cys Ser Arg Gly Ala Phe Ala Gln Gly Cys Arg
     370                 375                 380                
 Cys Val Glu Leu Asp Cys Trp Glu Gly Pro Gly Gly Glu Pro Val Ile
 385                 390                 395                 400
 Tyr His Gly His Thr Leu Thr Ser Lys Ile Leu Phe Arg Asp Val Val
                 405                 410                 415    
 Gln Ala Val Arg Asp His Ala Phe Thr Leu Ser Pro Tyr Pro Val Ile
             420                 425                 430        
 Leu Ser Leu Glu Asn His Cys Gly Leu Glu Gln Gln Ala Ala Met Ala
         435                 440                 445            
 Arg His Leu Cys Thr Ile Leu Gly Asp Met Leu Val Thr Gln Ala Leu
     450                 455                 460                
 Asp Ser Pro Asn Pro Glu Glu Leu Pro Ser Pro Glu Gln Leu Lys Gly
 465                 470                 475                 480
 Arg Val Leu Val Lys Gly Lys Lys Leu Pro Ala Ala Arg Ser Glu Asp
                 485                 490                 495    
 Gly Arg Ala Leu Ser Asp Arg Glu Glu Glu Glu Glu Asp Asp Glu Glu
             500                 505                 510        
 Glu Glu Glu Glu Val Glu Ala Ala Ala Gln Arg Arg Leu Ala Lys Gln
         515                 520                 525            
 Ile Ser Pro Glu Leu Ser Ala Leu Ala Val Tyr Cys His Ala Thr Arg
     530                 535                 540                
 Leu Arg Thr Leu His Pro Ala Pro Asn Ala Pro Gln Pro Cys Gln Val
 545                 550                 555                 560
 Ser Ser Leu Ser Glu Arg Lys Ala Lys Lys Leu Ile Arg Glu Ala Gly
                 565                 570                 575    
 Asn Ser Phe Val Arg His Asn Ala Arg Gln Leu Thr Arg Val Tyr Pro
             580                 585                 590        
 Leu Gly Leu Arg Met Asn Ser Ala Asn Tyr Ser Pro Gln Glu Met Trp
         595                 600                 605            
 Asn Ser Gly Cys Gln Leu Val Ala Leu Asn Phe Gln Thr Pro Gly Tyr
     610                 615                 620                
 Glu Met Asp Leu Asn Ala Gly Arg Phe Leu Val Asn Gly Gln Cys Gly
 625                 630                 635                 640
 Tyr Val Leu Lys Pro Ala Cys Leu Arg Gln Pro Asp Ser Thr Phe Asp
                 645                 650                 655    
 Pro Glu Tyr Pro Gly Pro Pro Arg Thr Thr Leu Ser Ile Gln Val Leu
             660                 665                 670        
 Thr Ala Gln Gln Leu Pro Lys Leu Asn Ala Glu Lys Pro His Ser Ile
         675                 680                 685            
 Val Asp Pro Leu Val Arg Ile Glu Ile His Gly Val Pro Ala Asp Cys
     690                 695                 700                
 Ala Arg Gln Glu Thr Asp Tyr Val Leu Asn Asn Gly Phe Asn Pro Arg
 705                 710                 715                 720
 Trp Gly Gln Thr Leu Gln Phe Gln Leu Arg Ala Pro Glu Leu Ala Leu
                 725                 730                 735    
 Val Arg Phe Val Val Glu Asp Tyr Asp Ala Thr Ser Pro Asn Asp Phe
             740                 745                 750        
 Val Gly Gln Phe Thr Leu Pro Leu Ser Ser Leu Lys Gln Gly Tyr Arg
         755                 760                 765            
 His Ile His Leu Leu Ser Lys Asp Gly Ala Ser Leu Ser Pro Ala Thr
     770                 775                 780                
 Leu Phe Ile Gln Ile Arg Ile Gln Arg Ser
 785                 790                



      <210> 150
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 150
 Met Ala Ala Val Pro Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala
   1               5                  10                  15    
 Gly Ile Ala Ser Ser Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala
              20                  25                  30        
 Ile Ala Asn Gly Gly Gly Val Ser Ala Gly Ser Leu Val Ala Thr Leu
          35                  40                  45            
 Gln Ser Val Gly Ala Ala Gly Leu Ser Thr Ser Ser Asn Ile Leu Leu
      50                  55                  60                
 Ala Ser Val Gly Ser Val Leu Gly Ala Cys Leu Gly Asn Ser Pro Ser
  65                  70                  75                  80
 Ser Ser Leu Pro Ala Glu Pro Glu Ala Lys Glu Asp Glu Ala Arg Glu
                  85                  90                  95    
 Asn Val Pro Gln Gly Glu Pro Pro Lys Pro Pro Leu Lys Ser Glu Lys
             100                 105                 110        
 His Glu Glu
         115



      <210> 151
      <211> 294
      <212> PRT
      <213> Homo sapiens


      <400> 151
 Met Ala Gln Ala Pro Ala Asp Pro Gly Arg Glu Ala Lys Arg Pro Gln
   1               5                  10                  15    
 Gln His Ala Ala Thr Ile Pro Glu Thr Pro Gly Pro Gln Phe Ser Gln
              20                  25                  30        
 Gln Arg Glu Glu Asp Ile Tyr Arg Phe Leu Lys Asp Asn Gly Pro Gln
          35                  40                  45            
 Arg Ala Leu Val Ile Ala Gln Ala Leu Gly Met Arg Thr Ala Lys Asp
      50                  55                  60                
 Val Asn Arg Asp Leu Tyr Arg Met Lys Ser Arg His Leu Leu Asp Met
  65                  70                  75                  80
 Asp Glu Gln Ser Lys Ala Trp Thr Ile Tyr Arg Pro Glu Asp Ser Gly
                  85                  90                  95    
 Arg Arg Ala Lys Ser Ala Ser Ile Ile Tyr Gln His Asn Pro Ile Asn
             100                 105                 110        
 Met Ile Cys Gln Asn Gly Pro Asn Ser Trp Ile Ser Ile Ala Asn Ser
         115                 120                 125            
 Glu Ala Ile Gln Ile Gly His Gly Asn Ile Ile Thr Arg Gln Thr Val
     130                 135                 140                
 Ser Arg Glu Asp Gly Ser Ala Gly Pro Arg His Leu Pro Ser Met Ala
 145                 150                 155                 160
 Pro Gly Asp Ser Ser Thr Trp Gly Thr Leu Val Asp Pro Trp Gly Pro
                 165                 170                 175    
 Gln Asp Ile His Met Glu Arg Ser Ile Leu Arg Arg Val Gln Leu Gly
             180                 185                 190        
 His Ser Asn Glu Met Arg Leu His Gly Val Pro Ser Glu Gly Pro Ala
         195                 200                 205            
 His Ile Pro Pro Gly Ser Pro Pro Val Ser Ala Thr Ala Ala Gly Pro
     210                 215                 220                
 Glu Ala Ser Phe Glu Ala Arg Ile Pro Ser Pro Gly Thr His Pro Glu
 225                 230                 235                 240
 Gly Glu Ala Ala Gln Arg Ile His Met Lys Ser Cys Phe Leu Glu Asp
                 245                 250                 255    
 Ala Thr Ile Gly Asn Ser Asn Lys Met Ser Ile Gln Pro Arg Gly Gly
             260                 265                 270        
 Trp Pro Arg Arg Ser Arg Arg Val Trp Arg Gly Gly Ala Arg Gly Gly
         275                 280                 285            
 Arg Ser Cys Cys Leu His
     290                



      <210> 152
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 152
 Met Ser Val Arg Ser Lys Leu Pro Asn Ser Pro Ala Ala Ser Ser His
   1               5                  10                  15    
 Pro Lys Leu Lys Ser Ser Lys Gly Ile Thr Lys Lys Pro Gln Ala Pro
              20                  25                  30        
 Ser Asn Asn Ala Ser Ser Ser Leu Ala Ser Leu Asn Pro Val Gly Lys
          35                  40                  45            
 Asn Thr Ser Ser Pro Ala Leu Pro Arg Thr Ala Pro Cys Ile Ser Glu
      50                  55                  60                
 Ser Pro Arg Lys Cys Ile Ser Ser Pro Asn Thr Pro Lys Ala Lys Val
  65                  70                  75                  80
 Ile Pro Ala Gln Asn Ser Ala Asp Leu Pro Glu Ser Thr Leu Leu Pro
                  85                  90                  95    
 Asn Lys Cys Ser Gly Lys Thr Gln Pro Lys Tyr Leu Lys His Asn His
             100                 105                 110        
 Ile Ser Ser Arg Asp Asn Ala Val Ser His Leu Ala Ala His Ser Asn
         115                 120                 125            
 Ser Ser Ser Lys Cys Pro Lys Leu Pro Lys Ala Asn Ile Pro Val Arg
     130                 135                 140                
 Pro Lys Pro Ser Phe Gln Ser Ser Ala Lys Met Thr Lys Thr Ser Ser
 145                 150                 155                 160
 Lys Thr Ile Ala Thr Gly Leu Gly Thr Gln Ser Gln Pro Ser Asp Gly
                 165                 170                 175    
 Ala Pro Gln Ala Lys Pro Val Pro Ala Gln Lys Leu Lys Ser Ala Leu
             180                 185                 190        
 Asn Leu Asn Gln Pro Val Ser Val Ser Ser Val Ser Pro Val Lys Ala
         195                 200                 205            
 Thr Gln Lys Ser Lys Asp Lys Asn Ile Val Ser Ala Thr Lys Lys Gln
     210                 215                 220                
 Pro Gln Asn Lys Ser Ala Phe Gln Lys Thr Gly Pro Ser Ser Leu Lys
 225                 230                 235                 240
 Ser Pro Gly Arg Thr Pro Leu Ser Ile Val Ser Leu Pro Gln Ser Ser
                 245                 250                 255    
 Thr Lys Thr Gln Thr Ala Pro Lys Ser Ala Gln Thr Val Ala Lys Ser
             260                 265                 270        
 Gln His Ser Thr Lys Gly Pro Pro Arg Ser Gly Lys Thr Pro Ala Ser
         275                 280                 285            
 Ile Arg Lys Pro Pro Ser Ser Val Lys Asp Ala Asp Ser Gly Asp Lys
     290                 295                 300                
 Lys Pro Thr Ala Lys Lys Lys Glu Asp Asp Asp His Tyr Phe Val Met
 305                 310                 315                 320
 Thr Gly Ser Lys Lys Pro Arg Lys
                 325            



      <210> 153
      <211> 1651
      <212> PRT
      <213> Homo sapiens


      <400> 153
 Met Ala Pro Thr Leu Phe Gln Lys Leu Phe Ser Lys Arg Thr Gly Leu
   1               5                  10                  15    
 Gly Ala Pro Gly Arg Asp Ala Arg Asp Pro Asp Cys Gly Phe Ser Trp
              20                  25                  30        
 Pro Leu Pro Glu Phe Asp Pro Ser Gln Ile Arg Leu Ile Val Tyr Gln
          35                  40                  45            
 Asp Cys Glu Arg Arg Gly Arg Asn Val Leu Phe Asp Ser Ser Val Lys
      50                  55                  60                
 Arg Arg Asn Glu Asp Ile Ser Val Ser Asp Leu Asn Thr Ile Tyr Ser
  65                  70                  75                  80
 Tyr Leu His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu
                  85                  90                  95    
 Arg Leu Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln
             100                 105                 110        
 Val Leu Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu
         115                 120                 125            
 Ser Gly Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser
     130                 135                 140                
 Phe Gly Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu
 145                 150                 155                 160
 Glu Pro Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp
                 165                 170                 175    
 Ser Ile Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe
             180                 185                 190        
 Arg Lys Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val
         195                 200                 205            
 Glu Val Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His
     210                 215                 220                
 Leu Thr Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln
 225                 230                 235                 240
 Ser Gly Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp
                 245                 250                 255    
 Ile Tyr Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg
             260                 265                 270        
 Leu Pro Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu
         275                 280                 285            
 Glu Ile Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu
     290                 295                 300                
 Cys Leu Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln
 305                 310                 315                 320
 Leu Leu Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met
                 325                 330                 335    
 Ser Val Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu
             340                 345                 350        
 Gln Ala Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp
         355                 360                 365            
 Tyr Val Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys
     370                 375                 380                
 Val Glu Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu
 385                 390                 395                 400
 Asp Lys Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys
                 405                 410                 415    
 Gln Phe Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His
             420                 425                 430        
 Val Glu Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met
         435                 440                 445            
 Val His Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His
     450                 455                 460                
 Ile Val Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu
 465                 470                 475                 480
 Glu His Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr
                 485                 490                 495    
 Tyr Arg Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu
             500                 505                 510        
 Glu Trp Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val
         515                 520                 525            
 Leu Leu Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala
     530                 535                 540                
 Met Thr Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys
 545                 550                 555                 560
 Met Asn Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala
                 565                 570                 575    
 Lys Trp Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu
             580                 585                 590        
 Gln Phe Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val
         595                 600                 605            
 Glu Gly Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly Leu Lys Arg
     610                 615                 620                
 Gly Asp Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr
 625                 630                 635                 640
 Phe Met Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu
                 645                 650                 655    
 Thr Val Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu Phe Arg Thr
             660                 665                 670        
 Glu Gln Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Glu Lys
         675                 680                 685            
 Lys Ser Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln
     690                 695                 700                
 Thr Ser Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Val Ser
 705                 710                 715                 720
 Gly Gly Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser
                 725                 730                 735    
 Ile Leu Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln
             740                 745                 750        
 Asp Asp Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile
         755                 760                 765            
 Met Pro Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln
     770                 775                 780                
 Pro Thr Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp
 785                 790                 795                 800
 Gln Val Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile
                 805                 810                 815    
 Ile Ser Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His
             820                 825                 830        
 Glu Phe Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val
         835                 840                 845            
 Ser Val Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln
     850                 855                 860                
 Phe Ser Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu
 865                 870                 875                 880
 Lys Asn Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln
                 885                 890                 895    
 Glu Leu Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile
             900                 905                 910        
 Glu Val Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn
         915                 920                 925            
 Ile Glu Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys
     930                 935                 940                
 Thr Gly Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu
 945                 950                 955                 960
 Thr Phe Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys
                 965                 970                 975    
 Arg Met Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg
             980                 985                 990        
 Glu Cys Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn
         995                1000                1005            
 Leu Ala Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser
    1010                1015                1020                
 Lys Tyr Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser
1025                1030                1035                1040
 Arg Asn Met Ala Lys Tyr Arg Asn Ile Leu Ser Ser Gln Ser Met Gln
                1045                1050                1055    
 Pro Pro Ile Ile Pro Leu Phe Pro Val Val Lys Lys Asp Met Thr Phe
            1060                1065                1070        
 Leu His Glu Gly Asn Asp Ser Lys Val Asp Gly Leu Val Asn Phe Glu
        1075                1080                1085            
 Lys Leu Arg Met Ile Ser Lys Glu Ile Arg Gln Val Val Arg Met Thr
    1090                1095                1100                
 Ser Ala Asn Met Asp Pro Ala Met Met Phe Arg Gln Arg Ser Leu Ser
1105                1110                1115                1120
 Gln Gly Ser Thr Asn Ser Asn Met Leu Asp Val Gln Gly Gly Ala His
                1125                1130                1135    
 Lys Lys Arg Ala Arg Arg Ser Ser Leu Leu Asn Ala Lys Lys Leu Tyr
            1140                1145                1150        
 Glu Asp Ala Gln Met Ala Arg Lys Val Lys Gln Tyr Leu Ser Ser Leu
        1155                1160                1165            
 Asp Val Glu Thr Asp Glu Glu Lys Phe Gln Met Met Ser Leu Gln Trp
    1170                1175                1180                
 Glu Pro Ala Tyr Gly Thr Leu Thr Lys Asn Leu Ser Glu Lys Arg Ser
1185                1190                1195                1200
 Ala Lys Ser Ser Glu Met Ser Pro Val Pro Met Arg Ser Ala Gly Gln
                1205                1210                1215    
 Thr Thr Lys Ala His Leu His Gln Pro His Arg Val Ser Gln Val Leu
            1220                1225                1230        
 Gln Val Pro Ala Val Asn Leu His Pro Ile Arg Lys Lys Gly Gln Thr
        1235                1240                1245            
 Lys Asp Pro Ala Leu Asn Thr Ser Leu Pro Gln Lys Val Leu Gly Thr
    1250                1255                1260                
 Thr Glu Glu Ile Ser Gly Lys Lys His Thr Glu Asp Thr Ile Ser Val
1265                1270                1275                1280
 Ala Ser Ser Leu His Ser Ser Pro Pro Ala Ser Pro Gln Gly Ser Pro
                1285                1290                1295    
 His Lys Gly Tyr Thr Leu Ile Pro Ser Ala Lys Ser Asp Asn Leu Ser
            1300                1305                1310        
 Asp Ser Ser His Ser Glu Ile Ser Ser Arg Ser Ser Ile Val Ser Asn
        1315                1320                1325            
 Cys Ser Val Asp Ser Met Ser Ala Ala Leu Gln Asp Glu Arg Cys Ser
    1330                1335                1340                
 Ser Gln Ala Leu Ala Val Pro Glu Ser Thr Gly Ala Leu Glu Lys Thr
1345                1350                1355                1360
 Glu His Ala Ser Gly Ile Gly Asp His Ser Gln His Gly Pro Gly Trp
                1365                1370                1375    
 Thr Leu Leu Lys Pro Ser Leu Ile Lys Cys Leu Ala Val Ser Ser Ser
            1380                1385                1390        
 Val Ser Asn Glu Glu Ile Ser Gln Glu His Ile Ile Ile Glu Ala Ala
        1395                1400                1405            
 Asp Ser Gly Arg Gly Ser Trp Thr Ser Cys Ser Ser Ser Ser His Asp
    1410                1415                1420                
 Asn Phe Gln Ser Leu Pro Asn Pro Lys Ser Trp Asp Phe Leu Asn Ser
1425                1430                1435                1440
 Tyr Arg His Thr His Leu Asp Asp Pro Ile Ala Glu Val Glu Pro Thr
                1445                1450                1455    
 Asp Ser Glu Pro Tyr Ser Cys Ser Lys Ser Cys Ser Arg Thr Cys Gly
            1460                1465                1470        
 Gln Cys Lys Gly Ser Leu Glu Arg Lys Ser Trp Thr Ser Ser Ser Ser
        1475                1480                1485            
 Leu Ser Asp Thr Tyr Glu Pro Asn Tyr Gly Thr Val Lys Arg Arg Val
    1490                1495                1500                
 Leu Glu Ser Thr Pro Ala Glu Ser Ser Glu Gly Leu Asp Pro Lys Asp
1505                1510                1515                1520
 Ala Thr Asp Pro Val Tyr Lys Thr Val Thr Ser Ser Thr Glu Lys Gly
                1525                1530                1535    
 Leu Ile Val Tyr Cys Val Thr Ser Pro Lys Lys Asp Asp Arg Tyr Arg
            1540                1545                1550        
 Glu Pro Pro Pro Thr Pro Pro Gly Tyr Leu Gly Ile Ser Leu Ala Asp
        1555                1560                1565            
 Leu Lys Glu Gly Pro His Thr His Leu Lys Pro Pro Asp Tyr Ser Val
    1570                1575                1580                
 Ala Val Gln Arg Ser Lys Met Met His Asn Ser Leu Ser Arg Leu Pro
1585                1590                1595                1600
 Pro Ala Ser Leu Ser Ser Asn Leu Val Ala Cys Val Pro Ser Lys Ile
                1605                1610                1615    
 Val Thr Gln Pro Gln Arg His Asn Leu Gln Pro Phe His Pro Lys Leu
            1620                1625                1630        
 Gly Asp Val Thr Asp Ala Asp Ser Glu Ala Asp Glu Asn Glu Gln Val
        1635                1640                1645            
 Ser Ala Val
    1650    



      <210> 154
      <211> 1424
      <212> PRT
      <213> Homo sapiens


      <400> 154
 Met Ser Asp Ser Trp Val Pro Asn Ser Ala Ser Gly Gln Asp Pro Gly
   1               5                  10                  15    
 Gly Arg Arg Arg Ala Trp Ala Glu Leu Leu Ala Gly Arg Val Lys Arg
              20                  25                  30        
 Glu Lys Tyr Asn Pro Glu Arg Ala Gln Lys Leu Lys Glu Ser Ala Val
          35                  40                  45            
 Arg Leu Leu Arg Ser His Gln Asp Leu Asn Ala Leu Leu Leu Glu Val
      50                  55                  60                
 Glu Gly Pro Leu Cys Lys Lys Leu Ser Leu Ser Lys Val Ile Asp Cys
  65                  70                  75                  80
 Asp Ser Ser Glu Ala Tyr Ala Asn His Ser Ser Ser Phe Ile Gly Ser
                  85                  90                  95    
 Ala Leu Gln Asp Gln Ala Ser Arg Leu Gly Val Pro Val Gly Ile Leu
             100                 105                 110        
 Ser Ala Gly Met Val Ala Ser Ser Val Gly Gln Ile Cys Thr Ala Pro
         115                 120                 125            
 Ala Glu Thr Ser His Pro Val Leu Leu Thr Val Glu Gln Arg Lys Lys
     130                 135                 140                
 Leu Ser Ser Leu Leu Glu Phe Ala Gln Tyr Leu Leu Ala His Ser Met
 145                 150                 155                 160
 Phe Ser Arg Leu Ser Phe Cys Gln Glu Leu Trp Lys Ile Gln Ser Ser
                 165                 170                 175    
 Leu Leu Leu Glu Ala Val Trp His Leu His Val Gln Gly Ile Val Ser
             180                 185                 190        
 Leu Gln Glu Leu Leu Glu Ser His Pro Asp Met His Ala Val Gly Ser
         195                 200                 205            
 Trp Leu Phe Arg Asn Leu Cys Cys Leu Cys Glu Gln Met Glu Ala Ser
     210                 215                 220                
 Cys Gln His Ala Asp Val Ala Arg Ala Met Leu Ser Asp Phe Val Gln
 225                 230                 235                 240
 Met Phe Val Leu Arg Gly Phe Gln Lys Asn Ser Asp Leu Arg Arg Thr
                 245                 250                 255    
 Val Glu Pro Glu Lys Met Pro Gln Val Thr Val Asp Val Leu Gln Arg
             260                 265                 270        
 Met Leu Ile Phe Ala Leu Asp Ala Leu Ala Ala Gly Val Gln Glu Glu
         275                 280                 285            
 Ser Ser Thr His Lys Ile Val Arg Cys Trp Phe Gly Val Phe Ser Gly
     290                 295                 300                
 His Thr Leu Gly Ser Val Ile Ser Thr Asp Pro Leu Lys Arg Phe Phe
 305                 310                 315                 320
 Ser His Thr Leu Thr Gln Ile Leu Thr His Ser Pro Val Leu Lys Ala
                 325                 330                 335    
 Ser Asp Ala Val Gln Met Gln Arg Glu Trp Ser Phe Ala Arg Thr His
             340                 345                 350        
 Pro Leu Leu Thr Ser Leu Tyr Arg Arg Leu Phe Val Met Leu Ser Ala
         355                 360                 365            
 Glu Glu Leu Val Gly His Leu Gln Glu Val Leu Glu Thr Gln Glu Val
     370                 375                 380                
 His Trp Gln Arg Val Leu Ser Phe Val Ser Ala Leu Val Val Cys Phe
 385                 390                 395                 400
 Pro Glu Ala Gln Gln Leu Leu Glu Asp Trp Val Ala Arg Leu Met Ala
                 405                 410                 415    
 Gln Ala Phe Glu Ser Cys Gln Leu Asp Ser Met Val Thr Ala Phe Leu
             420                 425                 430        
 Val Val Arg Gln Ala Ala Leu Glu Gly Pro Ser Ala Phe Leu Ser Tyr
         435                 440                 445            
 Ala Asp Trp Phe Lys Ala Ser Phe Gly Ser Thr Arg Gly Tyr His Gly
     450                 455                 460                
 Cys Ser Lys Lys Ala Leu Val Phe Leu Phe Thr Phe Leu Ser Glu Leu
 465                 470                 475                 480
 Val Pro Phe Glu Ser Pro Arg Tyr Leu Gln Val His Ile Leu His Pro
                 485                 490                 495    
 Pro Leu Val Pro Ser Lys Tyr Arg Ser Leu Leu Thr Asp Tyr Ile Ser
             500                 505                 510        
 Leu Ala Lys Thr Arg Leu Ala Asp Leu Lys Val Ser Ile Glu Asn Met
         515                 520                 525            
 Gly Leu Tyr Glu Asp Leu Ser Ser Ala Gly Asp Ile Thr Glu Pro His
     530                 535                 540                
 Ser Gln Ala Leu Gln Asp Val Glu Lys Ala Ile Met Val Phe Glu His
 545                 550                 555                 560
 Thr Gly Asn Ile Pro Val Thr Val Met Glu Ala Ser Ile Phe Arg Arg
                 565                 570                 575    
 Pro Tyr Tyr Val Ser His Phe Leu Pro Ala Leu Leu Thr Pro Arg Val
             580                 585                 590        
 Leu Pro Lys Val Pro Asp Ser Arg Val Ala Phe Ile Glu Ser Leu Lys
         595                 600                 605            
 Arg Ala Asp Lys Ile Pro Pro Ser Leu Tyr Ser Thr Tyr Cys Gln Ala
     610                 615                 620                
 Cys Ser Ala Ala Glu Glu Lys Pro Glu Asp Ala Ala Leu Gly Val Arg
 625                 630                 635                 640
 Ala Glu Pro Asn Ser Ala Glu Glu Pro Leu Gly Gln Leu Thr Ala Ala
                 645                 650                 655    
 Leu Gly Glu Leu Arg Ala Ser Met Thr Asp Pro Ser Gln Arg Asp Val
             660                 665                 670        
 Ile Ser Ala Gln Val Ala Val Ile Ser Glu Arg Leu Arg Ala Val Leu
         675                 680                 685            
 Gly His Asn Glu Asp Asp Ser Ser Val Glu Ile Ser Lys Ile Gln Leu
     690                 695                 700                
 Ser Ile Asn Thr Pro Arg Leu Glu Pro Arg Glu His Ile Ala Val Asp
 705                 710                 715                 720
 Leu Leu Leu Thr Ser Phe Cys Gln Asn Leu Met Ala Ala Ser Ser Val
                 725                 730                 735    
 Ala Pro Pro Glu Arg Gln Gly Pro Trp Ala Ala Leu Phe Val Arg Thr
             740                 745                 750        
 Met Cys Gly Arg Val Leu Pro Ala Val Leu Thr Arg Leu Cys Gln Leu
         755                 760                 765            
 Leu Arg His Gln Gly Pro Ser Leu Ser Ala Pro His Val Leu Gly Leu
     770                 775                 780                
 Ala Ala Leu Ala Val His Leu Gly Glu Ser Arg Ser Ala Leu Pro Glu
 785                 790                 795                 800
 Val Asp Val Gly Pro Pro Ala Pro Gly Ala Gly Leu Pro Val Pro Ala
                 805                 810                 815    
 Leu Phe Asp Ser Leu Leu Thr Cys Arg Thr Arg Asp Ser Leu Phe Phe
             820                 825                 830        
 Cys Leu Lys Phe Cys Thr Ala Ala Ile Ser Tyr Ser Leu Cys Lys Phe
         835                 840                 845            
 Ser Ser Gln Ser Arg Asp Thr Leu Cys Ser Cys Leu Ser Pro Gly Leu
     850                 855                 860                
 Ile Lys Lys Phe Gln Phe Leu Met Phe Arg Leu Phe Ser Glu Ala Arg
 865                 870                 875                 880
 Gln Pro Leu Ser Glu Glu Asp Val Ala Ser Leu Ser Trp Arg Pro Leu
                 885                 890                 895    
 His Leu Pro Ser Ala Asp Trp Gln Arg Ala Ala Leu Ser Leu Trp Thr
             900                 905                 910        
 His Arg Thr Phe Arg Glu Val Leu Lys Glu Glu Asp Val His Leu Thr
         915                 920                 925            
 Tyr Gln Asp Trp Leu His Leu Glu Leu Glu Ile Gln Pro Glu Ala Asp
     930                 935                 940                
 Ala Leu Ser Asp Thr Glu Arg Gln Asp Phe His Gln Trp Ala Ile His
 945                 950                 955                 960
 Glu His Phe Leu Pro Glu Ser Ser Ala Ser Gly Gly Cys Asp Gly Asp
                 965                 970                 975    
 Leu Gln Ala Ala Cys Thr Ile Leu Val Asn Ala Leu Met Asp Phe His
             980                 985                 990        
 Gln Ser Ser Arg Ser Tyr Asp His Ser Glu Asn Ser Asp Leu Val Phe
         995                1000                1005            
 Gly Gly Arg Thr Gly Asn Glu Asp Ile Ile Ser Arg Leu Gln Glu Met
    1010                1015                1020                
 Val Ala Asp Leu Glu Leu Gln Gln Asp Leu Ile Val Pro Leu Gly His
1025                1030                1035                1040
 Thr Pro Ser Gln Glu His Phe Leu Phe Glu Ile Phe Arg Arg Arg Leu
                1045                1050                1055    
 Gln Ala Leu Thr Ser Gly Trp Ser Val Ala Ala Ser Leu Gln Arg Gln
            1060                1065                1070        
 Arg Glu Leu Leu Met Tyr Lys Arg Ile Leu Leu Arg Leu Pro Ser Ser
        1075                1080                1085            
 Val Leu Cys Gly Ser Ser Phe Gln Ala Glu Gln Pro Ile Thr Ala Arg
    1090                1095                1100                
 Cys Glu Gln Phe Phe His Leu Val Asn Ser Glu Met Arg Asn Phe Cys
1105                1110                1115                1120
 Ser His Gly Gly Ala Leu Thr Gln Asp Ile Thr Ala His Phe Phe Arg
                1125                1130                1135    
 Gly Leu Leu Asn Ala Cys Leu Arg Ser Arg Asp Pro Ser Leu Met Val
            1140                1145                1150        
 Asp Phe Ile Leu Ala Lys Cys Gln Thr Lys Cys Pro Leu Ile Leu Thr
        1155                1160                1165            
 Ser Ala Leu Val Trp Trp Pro Ser Leu Glu Pro Val Leu Leu Cys Arg
    1170                1175                1180                
 Trp Arg Arg His Cys Gln Ser Pro Leu Pro Arg Glu Leu Gln Lys Leu
1185                1190                1195                1200
 Gln Glu Gly Arg Gln Phe Ala Ser Asp Phe Leu Ser Pro Glu Ala Ala
                1205                1210                1215    
 Ser Pro Ala Pro Asn Pro Asp Trp Leu Ser Ala Ala Ala Leu His Phe
            1220                1225                1230        
 Ala Ile Gln Gln Val Arg Glu Glu Asn Ile Arg Lys Gln Leu Lys Lys
        1235                1240                1245            
 Leu Asp Cys Glu Arg Glu Glu Leu Leu Val Phe Leu Phe Phe Phe Ser
    1250                1255                1260                
 Leu Met Gly Leu Leu Ser Ser His Leu Thr Ser Asn Ser Thr Thr Asp
1265                1270                1275                1280
 Leu Pro Lys Ala Phe His Val Cys Ala Ala Ile Leu Glu Cys Leu Glu
                1285                1290                1295    
 Lys Arg Lys Ile Ser Trp Leu Ala Leu Phe Gln Leu Thr Glu Ser Asp
            1300                1305                1310        
 Leu Arg Leu Gly Arg Leu Leu Leu Arg Val Ala Pro Asp Gln His Thr
        1315                1320                1325            
 Arg Leu Leu Pro Phe Ala Phe Tyr Ser Leu Leu Ser Tyr Phe His Glu
    1330                1335                1340                
 Asp Ala Ala Ile Arg Glu Glu Ala Phe Leu His Val Ala Val Asp Met
1345                1350                1355                1360
 Tyr Leu Lys Leu Val Gln Leu Phe Val Ala Gly Asp Thr Ser Thr Val
                1365                1370                1375    
 Ser Pro Pro Ala Gly Arg Ser Leu Glu Leu Lys Gly Gln Ala Gly Gln
            1380                1385                1390        
 Pro Arg Gly Thr Asp Asn Lys Ser Ser Ser Phe Ser Ala Ala Val Asn
        1395                1400                1405            
 Thr Ser Val Pro Glu Lys Glu Leu Leu Thr Arg Gly Arg Ala Ala Gly
    1410                1415                1420                





      <210> 155
      <211> 1381
      <212> PRT
      <213> Homo sapiens


      <400> 155
 Met Ser Asp Ser Trp Val Pro Asn Ser Ala Ser Gly Gln Asp Pro Gly
   1               5                  10                  15    
 Gly Arg Arg Arg Ala Trp Ala Glu Leu Leu Ala Gly Arg Val Lys Arg
              20                  25                  30        
 Glu Lys Tyr Asn Pro Glu Arg Ala Gln Lys Leu Lys Glu Ser Ala Val
          35                  40                  45            
 Arg Leu Leu Arg Ser His Gln Asp Leu Asn Ala Leu Leu Leu Glu Val
      50                  55                  60                
 Glu Gly Pro Leu Cys Lys Lys Leu Ser Leu Ser Lys Val Ile Asp Cys
  65                  70                  75                  80
 Asp Ser Ser Glu Ala Tyr Ala Asn His Ser Ser Ser Phe Ile Gly Ser
                  85                  90                  95    
 Ala Leu Gln Asp Gln Ala Ser Arg Leu Gly Val Pro Val Gly Ile Leu
             100                 105                 110        
 Ser Ala Gly Met Val Ala Ser Ser Val Gly Gln Ile Cys Thr Ala Pro
         115                 120                 125            
 Ala Glu Thr Ser His Pro Val Leu Leu Thr Val Glu Gln Arg Lys Lys
     130                 135                 140                
 Leu Ser Ser Leu Leu Glu Phe Ala Gln Tyr Leu Leu Ala His Ser Met
 145                 150                 155                 160
 Phe Ser Arg Leu Ser Phe Cys Gln Glu Leu Trp Lys Ile Gln Ser Ser
                 165                 170                 175    
 Leu Leu Leu Glu Ala Val Trp His Leu His Val Gln Gly Ile Val Ser
             180                 185                 190        
 Leu Gln Glu Leu Leu Glu Ser His Pro Asp Met His Ala Val Gly Ser
         195                 200                 205            
 Trp Leu Phe Arg Asn Leu Cys Cys Leu Cys Glu Gln Met Glu Ala Ser
     210                 215                 220                
 Cys Gln His Ala Asp Val Ala Arg Ala Met Leu Ser Asp Phe Val Gln
 225                 230                 235                 240
 Met Phe Val Leu Arg Gly Phe Gln Lys Asn Ser Asp Leu Arg Arg Thr
                 245                 250                 255    
 Val Glu Pro Glu Lys Met Pro Gln Val Thr Val Asp Val Leu Gln Arg
             260                 265                 270        
 Met Leu Ile Phe Ala Leu Asp Ala Leu Ala Ala Gly Val Gln Glu Glu
         275                 280                 285            
 Ser Ser Thr His Lys Ile Val Arg Cys Trp Phe Gly Val Phe Ser Gly
     290                 295                 300                
 His Thr Leu Gly Ser Val Ile Ser Thr Asp Pro Leu Lys Arg Phe Phe
 305                 310                 315                 320
 Ser His Thr Leu Thr Gln Ile Leu Thr His Ser Pro Val Leu Lys Ala
                 325                 330                 335    
 Ser Asp Ala Val Gln Met Gln Arg Glu Trp Ser Phe Ala Arg Thr His
             340                 345                 350        
 Pro Leu Leu Thr Ser Leu Tyr Arg Arg Leu Phe Val Met Leu Ser Ala
         355                 360                 365            
 Glu Glu Leu Val Gly His Leu Gln Glu Val Leu Glu Thr Gln Glu Val
     370                 375                 380                
 His Trp Gln Arg Val Leu Ser Phe Val Ser Ala Leu Val Val Cys Phe
 385                 390                 395                 400
 Pro Glu Ala Gln Gln Leu Leu Glu Asp Trp Val Ala Arg Leu Met Ala
                 405                 410                 415    
 Gln Ala Phe Glu Ser Cys Gln Leu Asp Ser Met Val Thr Ala Phe Leu
             420                 425                 430        
 Val Val Arg Gln Ala Ala Leu Glu Gly Pro Ser Ala Phe Leu Ser Tyr
         435                 440                 445            
 Ala Asp Trp Phe Lys Ala Ser Phe Gly Ser Thr Arg Gly Tyr His Gly
     450                 455                 460                
 Cys Ser Lys Lys Ala Leu Val Phe Leu Phe Thr Phe Leu Ser Glu Leu
 465                 470                 475                 480
 Val Pro Phe Glu Ser Pro Arg Tyr Leu Gln Val His Ile Leu His Pro
                 485                 490                 495    
 Pro Leu Val Pro Ser Lys Tyr Arg Ser Leu Leu Thr Asp Tyr Ile Ser
             500                 505                 510        
 Leu Ala Lys Thr Arg Leu Ala Asp Leu Lys Val Ser Ile Glu Asn Met
         515                 520                 525            
 Gly Leu Tyr Glu Asp Leu Ser Ser Ala Gly Asp Ile Thr Glu Pro His
     530                 535                 540                
 Ser Gln Ala Leu Gln Asp Val Glu Lys Ala Ile Met Val Phe Glu His
 545                 550                 555                 560
 Thr Gly Asn Ile Pro Val Thr Val Met Glu Ala Ser Ile Phe Arg Arg
                 565                 570                 575    
 Pro Tyr Tyr Val Ser His Phe Leu Pro Ala Leu Leu Thr Pro Arg Val
             580                 585                 590        
 Leu Pro Lys Val Pro Asp Ser Arg Val Ala Phe Ile Glu Ser Leu Lys
         595                 600                 605            
 Arg Ala Asp Lys Ile Pro Pro Ser Leu Tyr Ser Thr Tyr Cys Gln Ala
     610                 615                 620                
 Cys Ser Ala Ala Glu Glu Lys Pro Glu Asp Ala Ala Leu Gly Val Arg
 625                 630                 635                 640
 Ala Glu Pro Asn Ser Ala Glu Glu Pro Leu Gly Gln Leu Thr Ala Ala
                 645                 650                 655    
 Leu Gly Glu Leu Arg Ala Ser Met Thr Asp Pro Ser Gln Arg Asp Val
             660                 665                 670        
 Ile Ser Ala Gln Val Ala Val Ile Ser Glu Arg Leu Arg Ala Val Leu
         675                 680                 685            
 Gly His Asn Glu Asp Asp Ser Ser Val Glu Ile Ser Lys Ile Gln Leu
     690                 695                 700                
 Ser Ile Asn Thr Pro Arg Leu Glu Pro Arg Glu His Ile Ala Val Asp
 705                 710                 715                 720
 Leu Leu Leu Thr Ser Phe Cys Gln Asn Leu Met Ala Ala Ser Ser Val
                 725                 730                 735    
 Ala Pro Pro Glu Arg Gln Gly Pro Trp Ala Ala Leu Phe Val Arg Thr
             740                 745                 750        
 Met Cys Gly Arg Val Leu Pro Ala Val Leu Thr Arg Leu Cys Gln Leu
         755                 760                 765            
 Leu Arg His Gln Gly Pro Ser Leu Ser Ala Pro His Val Leu Gly Leu
     770                 775                 780                
 Ala Ala Leu Ala Val His Leu Gly Glu Ser Arg Ser Ala Leu Pro Glu
 785                 790                 795                 800
 Val Asp Val Gly Pro Pro Ala Pro Gly Ala Gly Leu Pro Val Pro Ala
                 805                 810                 815    
 Leu Phe Asp Ser Leu Leu Thr Cys Arg Thr Arg Asp Ser Leu Phe Phe
             820                 825                 830        
 Cys Leu Lys Phe Cys Thr Ala Ala Ile Ser Tyr Ser Leu Cys Lys Phe
         835                 840                 845            
 Ser Ser Gln Ser Arg Asp Thr Leu Cys Ser Cys Leu Ser Pro Gly Leu
     850                 855                 860                
 Ile Lys Lys Phe Gln Phe Leu Met Phe Arg Leu Phe Ser Glu Ala Arg
 865                 870                 875                 880
 Gln Pro Leu Ser Glu Glu Asp Val Ala Ser Leu Ser Trp Arg Pro Leu
                 885                 890                 895    
 His Leu Pro Ser Ala Asp Trp Gln Arg Ala Ala Leu Ser Leu Trp Thr
             900                 905                 910        
 His Arg Thr Phe Arg Glu Val Leu Lys Glu Glu Asp Val His Leu Thr
         915                 920                 925            
 Tyr Gln Asp Trp Leu His Leu Glu Leu Glu Ile Gln Pro Glu Ala Asp
     930                 935                 940                
 Ala Leu Ser Asp Thr Glu Arg Ser Arg Ser Tyr Asp His Ser Glu Asn
 945                 950                 955                 960
 Ser Asp Leu Val Phe Gly Gly Arg Thr Gly Asn Glu Asp Ile Ile Ser
                 965                 970                 975    
 Arg Leu Gln Glu Met Val Ala Asp Leu Glu Leu Gln Gln Asp Leu Ile
             980                 985                 990        
 Val Pro Leu Gly His Thr Pro Ser Gln Glu His Phe Leu Phe Glu Ile
         995                1000                1005            
 Phe Arg Arg Arg Leu Gln Ala Leu Thr Ser Gly Trp Ser Val Ala Ala
    1010                1015                1020                
 Ser Leu Gln Arg Gln Arg Glu Leu Leu Met Tyr Lys Arg Ile Leu Leu
1025                1030                1035                1040
 Arg Leu Pro Ser Ser Val Leu Cys Gly Ser Ser Phe Gln Ala Glu Gln
                1045                1050                1055    
 Pro Ile Thr Ala Arg Cys Glu Gln Phe Phe His Leu Val Asn Ser Glu
            1060                1065                1070        
 Met Arg Asn Phe Cys Ser His Gly Gly Ala Leu Thr Gln Asp Ile Thr
        1075                1080                1085            
 Ala His Phe Phe Arg Gly Leu Leu Asn Ala Cys Leu Arg Ser Arg Asp
    1090                1095                1100                
 Pro Ser Leu Met Val Asp Phe Ile Leu Ala Lys Cys Gln Thr Lys Cys
1105                1110                1115                1120
 Pro Leu Ile Leu Thr Ser Ala Leu Val Trp Trp Pro Ser Leu Glu Pro
                1125                1130                1135    
 Val Leu Leu Cys Arg Trp Arg Arg His Cys Gln Ser Pro Leu Pro Arg
            1140                1145                1150        
 Glu Leu Gln Lys Leu Gln Glu Gly Arg Gln Phe Ala Ser Asp Phe Leu
        1155                1160                1165            
 Ser Pro Glu Ala Ala Ser Pro Ala Pro Asn Pro Asp Trp Leu Ser Ala
    1170                1175                1180                
 Ala Ala Leu His Phe Ala Ile Gln Gln Val Arg Glu Glu Asn Ile Arg
1185                1190                1195                1200
 Lys Gln Leu Lys Lys Leu Asp Cys Glu Arg Glu Glu Leu Leu Val Phe
                1205                1210                1215    
 Leu Phe Phe Phe Ser Leu Met Gly Leu Leu Ser Ser His Leu Thr Ser
            1220                1225                1230        
 Asn Ser Thr Thr Asp Leu Pro Lys Ala Phe His Val Cys Ala Ala Ile
        1235                1240                1245            
 Leu Glu Cys Leu Glu Lys Arg Lys Ile Ser Trp Leu Ala Leu Phe Gln
    1250                1255                1260                
 Leu Thr Glu Ser Asp Leu Arg Leu Gly Arg Leu Leu Leu Arg Val Ala
1265                1270                1275                1280
 Pro Asp Gln His Thr Arg Leu Leu Pro Phe Ala Phe Tyr Ser Leu Leu
                1285                1290                1295    
 Ser Tyr Phe His Glu Asp Ala Ala Ile Arg Glu Glu Ala Phe Leu His
            1300                1305                1310        
 Val Ala Val Asp Met Tyr Leu Lys Leu Val Gln Leu Phe Val Ala Gly
        1315                1320                1325            
 Asp Thr Ser Thr Val Ser Pro Pro Ala Gly Arg Ser Leu Glu Leu Lys
    1330                1335                1340                
 Gly Gln Ala Gly Gln Pro Arg Gly Thr Asp Asn Lys Ser Ser Ser Phe
1345                1350                1355                1360
 Ser Ala Ala Val Asn Thr Ser Val Pro Glu Lys Glu Leu Leu Thr Arg
                1365                1370                1375    
 Gly Arg Ala Ala Gly
            1380    



      <210> 156
      <211> 162
      <212> PRT
      <213> Homo sapiens


      <400> 156
 Met Leu Arg Ala Val Gly Ser Leu Leu Arg Leu Gly Arg Gly Leu Thr
   1               5                  10                  15    
 Val Arg Cys Gly Pro Gly Ala Pro Leu Glu Ala Thr Arg Arg Pro Ala
              20                  25                  30        
 Pro Ala Leu Pro Pro Arg Gly Leu Pro Cys Tyr Ser Ser Gly Gly Ala
          35                  40                  45            
 Pro Ser Asn Ser Gly Pro Gln Gly His Gly Glu Ile His Arg Val Pro
      50                  55                  60                
 Thr Gln Arg Arg Pro Ser Gln Phe Asp Lys Lys Ile Leu Leu Trp Thr
  65                  70                  75                  80
 Gly Arg Phe Lys Ser Met Glu Glu Ile Pro Pro Arg Ile Pro Pro Glu
                  85                  90                  95    
 Met Ile Asp Thr Ala Arg Asn Lys Ala Arg Val Lys Ala Cys Tyr Ile
             100                 105                 110        
 Met Ile Gly Leu Thr Ile Ile Ala Cys Phe Ala Val Ile Val Ser Ala
         115                 120                 125            
 Lys Arg Ala Val Glu Arg His Glu Ser Leu Thr Ser Trp Asn Leu Ala
     130                 135                 140                
 Lys Lys Ala Lys Trp Arg Glu Glu Ala Ala Leu Ala Ala Gln Ala Lys
 145                 150                 155                 160
 Ala Lys
        



      <210> 157
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 157
 Met His Ala Ala Arg His Gly Trp Asp Val Glu Lys Asp Ala Pro Leu
   1               5                  10                  15    
 Phe Arg Asn Trp Ala Ile His Thr Gly Lys His Gln Pro Gly Val Asp
              20                  25                  30        
 Lys Pro Asp Pro Lys Thr Trp Lys Ala Asn Phe Arg Cys Ala Met Asn
          35                  40                  45            
 Ser Leu Pro Asp Ile Glu Glu Val Lys Asp Lys Ser Ile Lys Lys Gly
      50                  55                  60                
 Asn Asn Ala Phe Arg Val Tyr Arg Met Leu Pro Leu Ser Glu Arg Pro
  65                  70                  75                  80
 Ser Lys Lys Gly Lys Lys Pro Lys Thr Glu Lys Glu Asp Lys Val Lys
                  85                  90                  95    
 His Ile Lys Gln Glu Pro Val Glu Ser Ser Leu Gly Leu Ser Asn Gly
             100                 105                 110        
 Val Ser Asp Leu Ser Pro Glu Tyr Ala Val Leu Thr Ser Thr Ile Lys
         115                 120                 125            
 Asn Glu Val Asp Ser Thr Val Asn Ile Ile Val Val Gly Gln Ser His
     130                 135                 140                
 Leu Asp Ser Asn Ile Glu Asn Gln Glu Ile Val Thr Asn Pro Pro Asp
 145                 150                 155                 160
 Ile Cys Gln Val Val Glu Val Thr Thr Glu Ser Asp Glu Gln Pro Val
                 165                 170                 175    
 Ser Met Ser Glu Leu Tyr Pro Leu Gln Ile Ser Pro Val Ser Ser Tyr
             180                 185                 190        
 Ala Glu Ser Glu Thr Thr Asp Ser Val Pro Ser Asp Glu Glu Ser Ala
         195                 200                 205            
 Glu Gly Arg Pro His Trp Arg Lys Arg Asn Ile Glu Gly Lys Gln Tyr
     210                 215                 220                
 Leu Ser Asn Met Gly Thr Arg Gly Ser Tyr Leu Leu Pro Gly Met Ala
 225                 230                 235                 240
 Ser Phe Val Thr Ser Asn Lys Pro Asp Leu Gln Val Thr Ile Lys Glu
                 245                 250                 255    
 Glu Ser Asn Pro Val Pro Tyr Asn Ser Ser Trp Pro Pro Phe Gln Asp
             260                 265                 270        
 Leu Pro Leu Ser Ser Ser Met Thr Pro Ala Ser Ser Ser Ser Arg Pro
         275                 280                 285            
 Asp Arg Glu Thr Arg Ala Ser Val Ile Lys Lys Thr Ser Asp Ile Thr
     290                 295                 300                
 Gln Ala Arg Val Lys Ser Cys
 305                 310    



      <210> 158
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 158
 Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp Lys Ser Ile Lys
   1               5                  10                  15    
 Lys Gly Asn Asn Ala Phe Arg Val Tyr Arg Met Leu Pro Leu Ser Glu
              20                  25                  30        
 Arg Pro Ser Lys Lys Val Val Gly Gln Ser His Leu Asp Ser Asn Ile
          35                  40                  45            
 Glu Asn Gln Glu Ile Val Thr Asn Pro Pro Asp Ile Cys Gln Val Val
      50                  55                  60                
 Glu Val Thr Thr Glu Ser Asp Glu Gln Pro Val Ser Met Ser Glu Leu
  65                  70                  75                  80
 Tyr Pro Leu Gln Ile Ser Pro Val Ser Ser Tyr Ala Glu Ser Glu Thr
                  85                  90                  95    
 Thr Asp Ser Val Pro Ser Asp Glu Glu Ser Ala Glu Gly Arg Pro His
             100                 105                 110        
 Trp Arg Lys Arg Asn Ile Glu Gly Lys Gln Tyr Leu Ser Asn Met Gly
         115                 120                 125            
 Thr Arg Gly Ser Tyr Leu Leu Pro Gly Met Ala Ser Phe Val Thr Ser
     130                 135                 140                
 Asn Lys Pro Asp Leu Gln Val Thr Ile Lys Glu Glu Ser Asn Pro Val
 145                 150                 155                 160
 Pro Tyr Asn Ser Ser Trp Pro Pro Phe Gln Asp Leu Pro Leu Ser Ser
                 165                 170                 175    
 Ser Met Thr Pro Ala Ser Ser Ser Ser Arg Pro Asp Arg Glu Thr Arg
             180                 185                 190        
 Ala Ser Val Ile Lys Lys Thr Ser Asp Ile Thr Gln Ala Arg Val Lys
         195                 200                 205            
 Ser Cys
     210



      <210> 159
      <211> 529
      <212> PRT
      <213> Homo sapiens


      <400> 159
 Met Tyr Lys Arg Asn Gly Leu Met Ala Ser Val Leu Val Thr Ser Ala
   1               5                  10                  15    
 Thr Pro Gln Gly Ser Ser Ser Ser Asp Ser Leu Glu Gly Gln Ser Cys
              20                  25                  30        
 Asp Tyr Ala Ser Lys Ser Tyr Asp Ala Val Val Phe Asp Val Leu Lys
          35                  40                  45            
 Val Thr Pro Glu Glu Phe Ala Ser Gln Ile Thr Leu Met Asp Ile Pro
      50                  55                  60                
 Val Phe Lys Ala Ile Gln Pro Glu Glu Leu Ala Ser Cys Gly Trp Ser
  65                  70                  75                  80
 Lys Lys Glu Lys His Ser Leu Ala Pro Asn Val Val Ala Phe Thr Arg
                  85                  90                  95    
 Arg Phe Asn Gln Val Ser Phe Trp Val Val Arg Glu Ile Leu Thr Ala
             100                 105                 110        
 Gln Thr Leu Lys Ile Arg Ala Glu Ile Leu Ser His Phe Val Lys Ile
         115                 120                 125            
 Ala Lys Lys Leu Leu Glu Leu Asn Asn Leu His Ser Leu Met Ser Val
     130                 135                 140                
 Val Ser Ala Leu Gln Ser Ala Pro Ile Phe Arg Leu Thr Lys Thr Trp
 145                 150                 155                 160
 Ala Leu Leu Asn Arg Lys Asp Lys Thr Thr Phe Glu Lys Leu Asp Tyr
                 165                 170                 175    
 Leu Met Ser Lys Glu Asp Asn Tyr Lys Arg Thr Arg Glu Tyr Ile Arg
             180                 185                 190        
 Ser Leu Lys Met Val Pro Ser Ile Pro Tyr Leu Gly Ile Tyr Leu Leu
         195                 200                 205            
 Asp Leu Ile Tyr Ile Asp Ser Ala Tyr Pro Ala Ser Gly Ser Ile Met
     210                 215                 220                
 Glu Asn Glu Gln Arg Ser Asn Gln Met Asn Asn Ile Leu Arg Ile Ile
 225                 230                 235                 240
 Ala Asp Leu Gln Val Ser Cys Ser Tyr Asp His Leu Thr Thr Leu Pro
                 245                 250                 255    
 His Val Gln Lys Tyr Leu Lys Ser Val Arg Tyr Ile Glu Glu Leu Gln
             260                 265                 270        
 Lys Phe Val Glu Asp Asp Asn Tyr Lys Leu Ser Leu Arg Ile Glu Pro
         275                 280                 285            
 Gly Ser Ser Ser Pro Arg Leu Val Ser Ser Lys Glu Asp Leu Ala Gly
     290                 295                 300                
 Pro Ser Ala Gly Ser Gly Ser Ala Arg Phe Ser Arg Arg Pro Thr Cys
 305                 310                 315                 320
 Pro Asp Thr Ser Val Ala Gly Ser Leu Pro Thr Pro Pro Val Pro Arg
                 325                 330                 335    
 His Arg Lys Ser His Ser Leu Gly Asn Asn Arg Gly Arg Leu Tyr Ala
             340                 345                 350        
 Thr Leu Gly Pro Asn Trp Arg Val Pro Val Arg Asn Ser Pro Arg Thr
         355                 360                 365            
 Arg Ser Cys Val Tyr Ser Pro Thr Gly Pro Cys Ile Cys Ser Leu Gly
     370                 375                 380                
 Asn Ser Ala Ala Val Pro Thr Met Glu Gly Pro Leu Arg Arg Lys Thr
 385                 390                 395                 400
 Leu Leu Lys Glu Gly Arg Lys Pro Ala Leu Ser Ser Trp Thr Arg Tyr
                 405                 410                 415    
 Trp Val Ile Leu Ser Gly Ser Thr Leu Leu Tyr Tyr Gly Ala Lys Ser
             420                 425                 430        
 Leu Arg Gly Thr Asp Arg Lys His Val Ser Ile Val Gly Trp Met Val
         435                 440                 445            
 Gln Leu Pro Asp Asp Pro Glu His Pro Asp Ile Phe Gln Leu Asn Asn
     450                 455                 460                
 Pro Asp Lys Gly Asn Val Tyr Lys Phe Gln Thr Gly Ser Arg Phe His
 465                 470                 475                 480
 Ala Ile Leu Trp His Lys His Leu Asp Asp Ala Cys Lys Ser Asn Arg
                 485                 490                 495    
 Pro Gln Glu Ala Gly Ala Ala Pro Gly Pro Thr Gly Thr Asp Ser His
             500                 505                 510        
 Glu Val Asp His Leu Glu Gly Gly Ala Gly Lys Glu Ala Gly Pro Cys
         515                 520                 525            
 Ala
    



      <210> 160
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 160
 Met Ala Glu Glu Gln Gln Gln Pro Pro Pro Gln Gln Pro Asp Ala His
   1               5                  10                  15    
 Gln Gln Leu Pro Pro Ser Ala Pro Asn Ser Gly Val Ala Leu Pro Ala
              20                  25                  30        
 Leu Val Pro Gly Leu Pro Gly Thr Glu Ala Ser Ala Leu Gln His Lys
          35                  40                  45            
 Ile Lys Asn Ser Ile Cys Lys Thr Val Gln Ser Lys Val Asp Cys Ile
      50                  55                  60                
 Leu Gln Glu Val Glu Lys Phe Thr Asp Leu Glu Lys Leu Tyr Leu Tyr
  65                  70                  75                  80
 Leu Gln Leu Pro Ser Gly Leu Ser Asn Gly Glu Lys Ser Asp Gln Asn
                  85                  90                  95    
 Ala Met Ser Ser Ser Arg Ala Gln Gln Met His Ala Phe Ser Trp Ile
             100                 105                 110        
 Arg Asn Thr Leu Glu Glu His Pro Glu Thr Ser Leu Pro Lys Gln Glu
         115                 120                 125            
 Val Tyr Asp Glu Tyr Lys Ser Tyr Cys Asp Asn Leu Gly Tyr His Pro
     130                 135                 140                
 Leu Ser Ala Ala Asp Phe Gly Lys Ile Met Lys Asn Val Phe Pro Asn
 145                 150                 155                 160
 Met Lys Ala Arg Arg Leu Gly Thr Arg Gly Lys Ser Lys Tyr Cys Tyr
                 165                 170                 175    
 Ser Gly Leu Arg Lys Lys Ala Phe Val His Met Pro Thr Leu Pro Asn
             180                 185                 190        
 Leu Asp Phe His Lys Thr Gly Asn Gly Leu Glu Gly Ala Glu Pro Ser
         195                 200                 205            
 Gly Gln Leu Gln Asn Ile Asp Glu Glu Val Ile Ser Ser Ala Cys Arg
     210                 215                 220                
 Leu Val Cys Glu Trp Ala Gln Lys Val Leu Ser Gln Pro Phe Asp Thr
 225                 230                 235                 240
 Val Leu Glu Leu Ala Arg Phe Leu Val Lys Ser His Tyr Ile Gly Thr
                 245                 250                 255    
 Lys Ser Met Ala Ala Leu Thr Val Met Ala Ala Ala Pro Ala Gly Met
             260                 265                 270        
 Lys Gly Ile Thr Gln Pro Ser Ala Phe Ile Pro Thr Ala Glu Ser Asn
         275                 280                 285            
 Ser Phe Gln Pro Gln Val Lys Thr Leu Pro Ser Pro Ile Asp Ala Lys
     290                 295                 300                
 Gln Gln Leu Gln Arg Lys Ile Gln Lys Lys Gln Gln Glu Gln Lys Leu
 305                 310                 315                 320
 Gln Ser Pro Leu Pro Gly Glu Ser Ala Ala Lys Lys Ser Glu Ser Ala
                 325                 330                 335    
 Thr Ser Asn Gly Val Thr Asn Leu Pro Asn Gly Asn Pro Ser Ile Leu
             340                 345                 350        
 Ser Pro Gln Pro Ile Gly Ile Val Met Ala Ala Val Pro Ser Pro Ile
         355                 360                 365            
 Pro Val Gln Arg Thr Arg His Leu Val Thr Ser Pro Ser Pro Met Ser
     370                 375                 380                
 Ser Ser Asp Gly Lys Val Leu Pro Leu Asn Val Gln Val Ser Leu Ser
 385                 390                 395                 400
 Thr Cys Ser Leu
                



      <210> 161
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 161
 Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe
   1               5                  10                  15    
 Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp
              20                  25                  30        
 Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser
          35                  40                  45            
 Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn
      50                  55                  60                
 Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg
  65                  70                  75                  80
 Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln
                  85                  90                  95    
 Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu
             100                 105                 110        
 Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala
         115                 120                 125            
 Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu
     130                 135                 140                
 Leu Pro Gly Lys Val Leu Asn Trp Gln Lys Lys Trp Thr
 145                 150                 155        



      <210> 162
      <211> 354
      <212> PRT
      <213> Homo sapiens


      <400> 162
 Met Gln Glu Ala Ile Ile Leu Leu Ala Leu Leu Gly Ala Met Ser Gly
   1               5                  10                  15    
 Gly Glu Ala Leu His Leu Ile Leu Leu Pro Ala Thr Gly Asn Val Ala
              20                  25                  30        
 Glu Asn Ser Pro Pro Gly Thr Ser Val His Lys Phe Ser Val Lys Leu
          35                  40                  45            
 Ser Ala Ser Leu Ser Pro Val Ile Pro Gly Phe Pro Gln Ile Val Asn
      50                  55                  60                
 Ser Asn Pro Leu Thr Glu Ala Phe Arg Val Asn Trp Leu Ser Gly Thr
  65                  70                  75                  80
 Tyr Phe Glu Val Val Thr Thr Gly Met Glu Gln Leu Asp Phe Glu Thr
                  85                  90                  95    
 Gly Pro Asn Ile Phe Asp Leu Gln Ile Tyr Val Lys Asp Glu Val Gly
             100                 105                 110        
 Val Thr Asp Leu Gln Val Leu Thr Val Gln Val Thr Asp Val Asn Glu
         115                 120                 125            
 Pro Pro Gln Phe Gln Gly Asn Leu Ala Glu Gly Leu His Leu Tyr Ile
     130                 135                 140                
 Val Glu Arg Ala Asn Pro Gly Phe Ile Tyr Gln Val Glu Ala Phe Asp
 145                 150                 155                 160
 Pro Glu Asp Thr Ser Arg Asn Ile Pro Leu Ser Tyr Phe Leu Ile Ser
                 165                 170                 175    
 Pro Pro Lys Ser Phe Arg Met Ser Ala Asn Gly Thr Leu Phe Ser Thr
             180                 185                 190        
 Thr Glu Leu Asp Phe Glu Ala Gly His Arg Ser Phe His Leu Ile Val
         195                 200                 205            
 Glu Val Arg Asp Ser Gly Gly Leu Lys Ala Ser Thr Glu Leu Gln Val
     210                 215                 220                
 Asn Ile Val Asn Leu Asn Asp Glu Val Pro Arg Phe Thr Ser Pro Thr
 225                 230                 235                 240
 Arg Val Tyr Thr Val Leu Glu Glu Leu Ser Pro Gly Thr Ile Val Ala
                 245                 250                 255    
 Asn Ile Thr Ala Glu Asp Pro Asp Asp Glu Gly Phe Pro Ser His Leu
             260                 265                 270        
 Leu Tyr Ser Ile Thr Thr Val Ser Lys Tyr Phe Met Ile Asn Gln Leu
         275                 280                 285            
 Thr Gly Thr Ile Gln Val Ala Gln Arg Ile Asp Arg Asp Ala Gly Glu
     290                 295                 300                
 Leu Arg Gln Asn Pro Thr Ile Ser Leu Glu Val Leu Val Lys Asp Arg
 305                 310                 315                 320
 Pro Tyr Gly Gly Gln Glu Asn Arg Ile Gln Ile Thr Phe Ile Val Glu
                 325                 330                 335    
 Asp Val Asn Asp Asn Pro Ala Thr Cys Gln Lys Phe Thr Phe Arg Trp
             340                 345                 350        
 Arg Asn
        



      <210> 163
      <211> 1579
      <212> PRT
      <213> Homo sapiens


      <400> 163
 Met Lys Leu Cys Pro Arg Tyr Asn Ser Gln Glu Glu Thr Leu Glu Phe
   1               5                  10                  15    
 Val Ala Asp Tyr Ser Gly Gln Asp Asn Phe Leu Gln Arg Val Gly Gln
              20                  25                  30        
 Asn Gly Leu Lys Asn Ser Glu Lys Glu Ser Thr Val Asn Ser Ile Phe
          35                  40                  45            
 Gln Val Ile Arg Ser Cys Asn Arg Ser Leu Glu Thr Asp Glu Glu Asp
      50                  55                  60                
 Ser Pro Ser Glu Gly Asn Ser Ser Arg Lys Ser Ser Leu Lys Asp Lys
  65                  70                  75                  80
 Ser Arg Trp Gln Phe Ile Ile Gly Asp Leu Leu Asp Ser Asp Asn Asp
                  85                  90                  95    
 Ile Phe Glu Gln Ser Lys Glu Tyr Asp Ser His Gly Ser Glu Asp Ser
             100                 105                 110        
 Gln Lys Ala Phe Asp His Gly Thr Glu Leu Ile Pro Trp Tyr Val Leu
         115                 120                 125            
 Ser Ile Gln Ala Asp Val His Gln Phe Leu Leu Gln Gly Ala Thr Val
     130                 135                 140                
 Ile His Tyr Asp Gln Asp Thr His Leu Ser Ala Arg Cys Phe Leu Gln
 145                 150                 155                 160
 Leu Gln Pro Asp Asn Ser Thr Leu Thr Trp Val Lys Pro Thr Thr Ala
                 165                 170                 175    
 Ser Pro Ala Ser Ser Lys Ala Lys Leu Gly Val Leu Asn Asn Thr Ala
             180                 185                 190        
 Glu Pro Gly Lys Phe Pro Leu Leu Gly Asn Ala Gly Leu Ser Ser Leu
         195                 200                 205            
 Thr Glu Gly Val Leu Asp Leu Phe Ala Val Lys Ala Val Tyr Met Gly
     210                 215                 220                
 His Pro Gly Ile Asp Ile His Thr Val Cys Val Gln Asn Lys Leu Gly
 225                 230                 235                 240
 Ser Met Phe Leu Ser Glu Thr Gly Val Thr Leu Leu Tyr Gly Leu Gln
                 245                 250                 255    
 Thr Thr Asp Asn Arg Leu Leu His Phe Val Ala Pro Lys His Thr Ala
             260                 265                 270        
 Lys Met Leu Phe Ser Gly Leu Leu Glu Leu Thr Arg Ala Val Arg Lys
         275                 280                 285            
 Met Arg Lys Phe Pro Asp Gln Arg Gln Gln Trp Leu Arg Lys Gln Tyr
     290                 295                 300                
 Val Ser Leu Tyr Gln Glu Asp Gly Arg Tyr Glu Gly Pro Thr Leu Ala
 305                 310                 315                 320
 His Ala Val Glu Leu Phe Gly Gly Arg Arg Trp Ser Ala Arg Asn Pro
                 325                 330                 335    
 Ser Pro Gly Thr Ser Ala Lys Asn Ala Glu Lys Pro Asn Met Gln Arg
             340                 345                 350        
 Asn Asn Thr Leu Gly Ile Ser Thr Thr Lys Lys Lys Lys Lys Ile Leu
         355                 360                 365            
 Met Arg Gly Glu Ser Gly Glu Val Thr Asp Asp Glu Met Ala Thr Arg
     370                 375                 380                
 Lys Ala Lys Met His Lys Glu Cys Arg Ser Arg Ser Gly Ser Asp Pro
 385                 390                 395                 400
 Gln Asp Ile Asn Glu Gln Glu Glu Ser Glu Val Asn Ala Ile Ala Asn
                 405                 410                 415    
 Pro Pro Asn Pro Leu Pro Ser Arg Arg Ala His Ser Leu Thr Thr Ala
             420                 425                 430        
 Gly Ser Pro Asn Leu Ala Ala Gly Thr Ser Ser Pro Ile Arg Pro Val
         435                 440                 445            
 Ser Ser Pro Val Leu Ser Ser Ser Asn Lys Ser Pro Ser Ser Ala Trp
     450                 455                 460                
 Ser Ser Ser Ser Trp His Gly Arg Ile Lys Gly Gly Met Lys Gly Phe
 465                 470                 475                 480
 Gln Ser Phe Met Val Ser Asp Ser Asn Met Ser Phe Val Glu Phe Val
                 485                 490                 495    
 Glu Leu Phe Lys Ser Phe Ser Val Arg Gln Ala Lys Asp Leu Lys Asp
             500                 505                 510        
 Leu Phe Asp Val Tyr Ala Val Pro Cys Asn Arg Ser Gly Ser Glu Ser
         515                 520                 525            
 Ala Pro Leu Tyr Thr Asn Leu Thr Ile Asp Glu Asn Thr Ser Asp Leu
     530                 535                 540                
 Gln Pro Asp Leu Asp Leu Leu Thr Arg Asn Val Ser Asp Leu Gly Leu
 545                 550                 555                 560
 Phe Ile Lys Ser Lys Gln Gln Leu Ser Asp Asn Gln Arg Gln Ile Ser
                 565                 570                 575    
 Asp Ala Ile Ala Ala Ala Ser Ile Val Thr Asn Gly Thr Gly Ile Glu
             580                 585                 590        
 Ser Thr Ser Leu Gly Ile Phe Gly Val Gly Ile Leu Gln Leu Asn Asp
         595                 600                 605            
 Phe Leu Val Asn Cys Gln Gly Glu His Cys Thr Tyr Asp Glu Ile Leu
     610                 615                 620                
 Ser Ile Ile Gln Lys Phe Glu Pro Ser Ile Ser Met Cys His Gln Gly
 625                 630                 635                 640
 Leu Met Ser Phe Glu Gly Phe Ala Arg Phe Leu Met Asp Lys Glu Asn
                 645                 650                 655    
 Phe Ala Ser Lys Asn Asp Glu Ser Gln Glu Asn Ile Lys Glu Leu Gln
             660                 665                 670        
 Leu Pro Leu Ser Tyr Tyr Tyr Ile Glu Ser Ser His Asn Thr Tyr Leu
         675                 680                 685            
 Thr Gly His Gln Leu Lys Gly Glu Ser Ser Val Glu Leu Tyr Ser Gln
     690                 695                 700                
 Val Leu Leu Gln Gly Cys Arg Ser Val Glu Leu Asp Cys Trp Asp Gly
 705                 710                 715                 720
 Asp Asp Gly Met Pro Ile Ile Tyr His Gly His Thr Leu Thr Thr Lys
                 725                 730                 735    
 Ile Pro Phe Lys Glu Val Val Glu Ala Ile Asp Arg Ser Ala Phe Ile
             740                 745                 750        
 Asn Ser Asp Leu Pro Ile Ile Ile Ser Ile Glu Asn His Cys Ser Leu
         755                 760                 765            
 Pro Gln Gln Arg Lys Met Ala Glu Ile Phe Lys Thr Val Phe Gly Glu
     770                 775                 780                
 Lys Leu Val Thr Lys Phe Leu Phe Glu Thr Asp Phe Ser Asp Asp Pro
 785                 790                 795                 800
 Met Leu Pro Ser Pro Asp Gln Leu Arg Lys Lys Val Leu Leu Lys Asn
                 805                 810                 815    
 Lys Lys Leu Lys Ala His Gln Thr Pro Val Asp Ile Leu Lys Gln Lys
             820                 825                 830        
 Ala His Gln Leu Ala Ser Met Gln Val Gln Ala Tyr Asn Gly Gly Asn
         835                 840                 845            
 Ala Asn Pro Arg Pro Ala Asn Asn Glu Glu Glu Glu Asp Glu Glu Asp
     850                 855                 860                
 Glu Tyr Asp Tyr Asp Tyr Glu Ser Leu Ser Asp Asp Asn Ile Leu Glu
 865                 870                 875                 880
 Asp Arg Pro Glu Asn Lys Ser Cys Asn Asp Lys Leu Gln Phe Glu Tyr
                 885                 890                 895    
 Asn Glu Glu Ile Pro Lys Arg Ile Lys Lys Ala Asp Asn Ser Ala Cys
             900                 905                 910        
 Asn Lys Gly Lys Val Tyr Asp Met Glu Leu Gly Glu Glu Phe Tyr Leu
         915                 920                 925            
 Asp Gln Asn Lys Lys Glu Ser Arg Gln Ile Ala Pro Glu Leu Ser Asp
     930                 935                 940                
 Leu Val Ile Tyr Cys Gln Ala Val Lys Phe Pro Gly Leu Ser Thr Leu
 945                 950                 955                 960
 Asn Ala Ser Gly Ser Ser Arg Gly Lys Glu Arg Lys Ser Arg Lys Ser
                 965                 970                 975    
 Ile Phe Gly Asn Asn Pro Gly Arg Met Ser Pro Gly Glu Thr Ala Ser
             980                 985                 990        
 Phe Asn Lys Thr Ser Gly Lys Ser Ser Cys Glu Gly Ile Arg Gln Thr
         995                1000                1005            
 Trp Glu Glu Ser Ser Ser Pro Leu Asn Pro Thr Thr Ser Leu Ser Ala
    1010                1015                1020                
 Ile Ile Arg Thr Pro Lys Cys Tyr His Ile Ser Ser Leu Asn Glu Asn
1025                1030                1035                1040
 Ala Ala Lys Arg Leu Cys Arg Arg Tyr Ser Gln Lys Leu Thr Gln His
                1045                1050                1055    
 Thr Ala Cys Gln Leu Leu Arg Thr Tyr Pro Ala Ala Thr Arg Ile Asp
            1060                1065                1070        
 Ser Ser Asn Pro Asn Pro Leu Met Phe Trp Leu His Gly Ile Gln Leu
        1075                1080                1085            
 Val Ala Leu Asn Tyr Gln Thr Asp Asp Leu Pro Leu His Leu Asn Ala
    1090                1095                1100                
 Ala Met Phe Glu Ala Asn Gly Gly Cys Gly Tyr Val Leu Lys Pro Pro
1105                1110                1115                1120
 Val Leu Trp Asp Lys Asn Cys Pro Met Tyr Gln Lys Phe Ser Pro Leu
                1125                1130                1135    
 Glu Arg Asp Leu Asp Ser Met Asp Pro Ala Val Tyr Ser Leu Thr Ile
            1140                1145                1150        
 Val Ser Gly Gln Asn Val Cys Pro Ser Asn Ser Met Gly Ser Pro Cys
        1155                1160                1165            
 Ile Glu Val Asp Val Leu Gly Met Pro Leu Asp Ser Cys His Phe Arg
    1170                1175                1180                
 Thr Lys Pro Ile His Arg Asn Thr Leu Asn Pro Met Trp Asn Glu Gln
1185                1190                1195                1200
 Phe Leu Phe Arg Val His Phe Glu Asp Leu Val Phe Leu Arg Phe Ala
                1205                1210                1215    
 Val Val Glu Asn Asn Ser Ser Ala Val Thr Ala Gln Arg Ile Ile Pro
            1220                1225                1230        
 Leu Lys Ala Leu Lys Arg Gly Tyr Arg His Leu Gln Leu Arg Asn Leu
        1235                1240                1245            
 His Asn Glu Val Leu Glu Ile Ser Ser Leu Phe Ile Asn Ser Arg Arg
    1250                1255                1260                
 Met Glu Glu Asn Ser Ser Gly Asn Thr Met Ser Ala Ser Ser Met Phe
1265                1270                1275                1280
 Asn Thr Glu Glu Arg Lys Cys Leu Gln Thr His Arg Val Thr Val His
                1285                1290                1295    
 Gly Val Pro Gly Pro Glu Pro Phe Thr Val Phe Thr Ile Asn Gly Gly
            1300                1305                1310        
 Thr Lys Ala Lys Gln Leu Leu Gln Gln Ile Leu Thr Asn Glu Gln Asp
        1315                1320                1325            
 Ile Lys Pro Val Thr Thr Asp Tyr Phe Leu Met Glu Glu Lys Tyr Phe
    1330                1335                1340                
 Ile Ser Lys Glu Lys Asn Glu Cys Arg Lys Gln Pro Phe Gln Arg Ala
1345                1350                1355                1360
 Ile Gly Pro Glu Glu Glu Ile Met Gln Ile Leu Ser Ser Trp Phe Pro
                1365                1370                1375    
 Glu Glu Gly Tyr Met Gly Arg Ile Val Leu Lys Thr Gln Gln Glu Asn
            1380                1385                1390        
 Leu Glu Glu Lys Asn Ile Val Gln Asp Asp Lys Glu Val Ile Leu Ser
        1395                1400                1405            
 Ser Glu Glu Glu Ser Phe Phe Val Gln Val His Asp Val Ser Pro Glu
    1410                1415                1420                
 Gln Pro Arg Thr Val Ile Lys Ala Pro Arg Val Ser Thr Ala Gln Asp
1425                1430                1435                1440
 Val Ile Gln Gln Thr Leu Cys Lys Ala Lys Tyr Ser Tyr Ser Ile Leu
                1445                1450                1455    
 Ser Asn Pro Asn Pro Ser Asp Tyr Val Leu Leu Glu Glu Val Val Lys
            1460                1465                1470        
 Asp Thr Thr Asn Lys Lys Thr Thr Thr Pro Lys Ser Ser Gln Arg Val
        1475                1480                1485            
 Leu Leu Asp Gln Glu Cys Val Phe Gln Ala Gln Ser Lys Trp Lys Gly
    1490                1495                1500                
 Ala Gly Lys Phe Ile Leu Lys Leu Lys Glu Gln Val Gln Ala Ser Arg
1505                1510                1515                1520
 Glu Asp Lys Lys Lys Gly Ile Ser Phe Ala Ser Glu Leu Lys Lys Leu
                1525                1530                1535    
 Thr Lys Ser Thr Lys Gln Pro Arg Gly Leu Thr Ser Pro Ser Gln Leu
            1540                1545                1550        
 Leu Thr Ser Glu Ser Ile Gln Thr Lys Glu Glu Lys Pro Val Gly Gly
        1555                1560                1565            
 Leu Ser Ser Ser Asp Thr Met Asp Tyr Arg Gln
    1570                1575                



      <210> 164
      <211> 407
      <212> PRT
      <213> Homo sapiens


      <400> 164
 Met Asp Gly Leu Pro Gly Arg Ala Leu Gly Ala Ala Cys Leu Leu Leu
   1               5                  10                  15    
 Leu Ala Ala Gly Trp Leu Gly Pro Glu Ala Trp Gly Ser Pro Thr Pro
              20                  25                  30        
 Pro Pro Thr Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ala Pro
          35                  40                  45            
 Gly Gly Ser Gln Asp Thr Cys Thr Ser Cys Gly Gly Phe Arg Arg Pro
      50                  55                  60                
 Glu Glu Leu Gly Arg Val Asp Gly Asp Phe Leu Glu Ala Val Lys Arg
  65                  70                  75                  80
 His Ile Leu Ser Arg Leu Gln Met Arg Gly Arg Pro Asn Ile Thr His
                  85                  90                  95    
 Ala Val Pro Lys Ala Ala Met Val Thr Ala Leu Arg Lys Leu His Ala
             100                 105                 110        
 Gly Lys Val Arg Glu Asp Gly Arg Val Glu Ile Pro His Leu Asp Gly
         115                 120                 125            
 His Ala Ser Pro Gly Ala Asp Gly Gln Glu Arg Val Ser Glu Ile Ile
     130                 135                 140                
 Ser Phe Ala Glu Thr Asp Gly Leu Ala Ser Ser Arg Val Arg Leu Tyr
 145                 150                 155                 160
 Phe Phe Ile Ser Asn Glu Gly Asn Gln Asn Leu Phe Val Val Gln Ala
                 165                 170                 175    
 Ser Leu Trp Leu Tyr Leu Lys Leu Leu Pro Tyr Val Leu Glu Lys Gly
             180                 185                 190        
 Ser Arg Arg Lys Val Arg Val Lys Val Tyr Phe Gln Glu Gln Gly His
         195                 200                 205            
 Gly Asp Arg Trp Asn Met Val Glu Lys Arg Val Asp Leu Lys Arg Ser
     210                 215                 220                
 Gly Trp His Thr Phe Pro Leu Thr Glu Ala Ile Gln Ala Leu Phe Glu
 225                 230                 235                 240
 Arg Gly Glu Arg Arg Leu Asn Leu Asp Val Gln Cys Asp Ser Cys Gln
                 245                 250                 255    
 Glu Leu Ala Val Val Pro Val Phe Val Asp Pro Gly Glu Glu Ser His
             260                 265                 270        
 Arg Pro Phe Val Val Val Gln Ala Arg Leu Gly Asp Ser Arg His Arg
         275                 280                 285            
 Ile Arg Lys Arg Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys
     290                 295                 300                
 Arg Gln Gln Phe Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp
 305                 310                 315                 320
 Ile Ile Ala Pro Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys
                 325                 330                 335    
 Pro Ala Tyr Leu Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr
             340                 345                 350        
 Ala Val Val Asn Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val
         355                 360                 365            
 Asn Ser Cys Cys Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr
     370                 375                 380                
 Phe Asp Asp Glu Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile
 385                 390                 395                 400
 Val Glu Glu Cys Gly Cys Ala
                 405        



      <210> 165
      <211> 407
      <212> PRT
      <213> Homo sapiens


      <400> 165
 Met Ala Leu Gly Val Gly Arg Ala Arg Pro Gly Leu Ser Cys Gly Val
   1               5                  10                  15    
 Ile Ser Pro Pro Cys Ala Pro Thr Arg Asn Ser His Pro Gly Pro Gly
              20                  25                  30        
 Cys Thr Ala Ser Pro Pro Ala Pro Pro Gly Trp Pro Phe Ser Gln Arg
          35                  40                  45            
 Gly Pro Gly Arg Trp Ser Thr Thr Glu Leu Arg Lys Glu Lys Ser Arg
      50                  55                  60                
 Asp Ala Ala Arg Ser Arg Arg Ser Gln Glu Thr Glu Val Leu Tyr Gln
  65                  70                  75                  80
 Leu Ala His Thr Leu Pro Phe Ala Arg Gly Val Ser Ala His Leu Asp
                  85                  90                  95    
 Lys Ala Ser Ile Met Arg Leu Thr Ile Ser Tyr Leu Arg Met His Arg
             100                 105                 110        
 Leu Cys Ala Ala Gly Glu Trp Asn Gln Val Gly Ala Gly Gly Glu Pro
         115                 120                 125            
 Leu Asp Ala Cys Tyr Leu Lys Ala Leu Glu Gly Phe Val Met Val Leu
     130                 135                 140                
 Thr Ala Glu Gly Asp Met Ala Tyr Leu Ser Glu Asn Val Ser Lys His
 145                 150                 155                 160
 Leu Gly Leu Ser Gln Leu Glu Leu Ile Gly His Ser Ile Phe Asp Phe
                 165                 170                 175    
 Ile His Pro Cys Asp Gln Glu Glu Leu Gln Asp Ala Leu Thr Pro Gln
             180                 185                 190        
 Gln Thr Leu Ser Arg Arg Lys Val Glu Ala Pro Thr Glu Arg Cys Phe
         195                 200                 205            
 Ser Leu Arg Met Lys Ser Thr Leu Thr Ser Arg Gly Arg Thr Leu Asn
     210                 215                 220                
 Leu Lys Ala Ala Thr Trp Lys Val Leu Asn Cys Ser Gly His Met Arg
 225                 230                 235                 240
 Ala Tyr Lys Pro Pro Ala Gln Thr Ser Pro Ala Gly Ser Pro Asp Ser
                 245                 250                 255    
 Glu Pro Pro Leu Gln Cys Leu Val Leu Ile Cys Glu Ala Ile Pro His
             260                 265                 270        
 Pro Gly Ser Leu Glu Pro Pro Leu Gly Arg Gly Ala Phe Leu Ser Arg
         275                 280                 285            
 His Ser Leu Asp Met Lys Phe Thr Tyr Cys Asp Asp Arg Ile Ala Glu
     290                 295                 300                
 Val Ala Gly Tyr Ser Pro Asp Asp Leu Ile Gly Cys Ser Ala Tyr Glu
 305                 310                 315                 320
 Tyr Ile His Ala Leu Asp Ser Asp Ala Val Ser Lys Ser Ile His Thr
                 325                 330                 335    
 Cys Met Tyr Pro Ile Ser Pro Gly Ala Lys Pro Ala Ala Thr Trp Pro
             340                 345                 350        
 Pro Ala Asp Thr Arg Thr Pro Gln Leu Pro Ile Pro Gln Asp Ala Leu
         355                 360                 365            
 Pro Pro His Leu Asn Thr Ser Ser Leu Leu Pro Lys Pro Gln Gly Thr
     370                 375                 380                
 Val Ser Phe Leu Ala Pro Ser Tyr Pro Val Pro Arg Ser Phe Ser Pro
 385                 390                 395                 400
 His Leu Pro Pro Trp Trp Pro
                 405        



      <210> 166
      <211> 418
      <212> PRT
      <213> Homo sapiens


      <400> 166
 Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe
   1               5                  10                  15    
 Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp
              20                  25                  30        
 Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser
          35                  40                  45            
 Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn
      50                  55                  60                
 Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg
  65                  70                  75                  80
 Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln
                  85                  90                  95    
 Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu
             100                 105                 110        
 Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala
         115                 120                 125            
 Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu
     130                 135                 140                
 Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala
 145                 150                 155                 160
 Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Glu
                 165                 170                 175    
 Cys Val Arg Val Pro Arg Gly Gly Ile Pro Pro Arg Ala His Ser Arg
             180                 185                 190        
 Asp Ser Ser Asp Ser Ala Asp Gly Arg Ala Thr Pro Ser Glu Asn Leu
         195                 200                 205            
 Val Pro Ser Ser Ala Arg Val Asp Lys Pro Pro Ser Val Leu Pro Tyr
     210                 215                 220                
 Phe Asn Arg Pro Pro Ser Ala Leu Pro Leu Met Gly Leu Pro Pro Pro
 225                 230                 235                 240
 Pro Ile Pro Pro Pro Pro Pro Leu Ser Ser Ser Phe Gly Val Pro Pro
                 245                 250                 255    
 Pro Pro Pro Gly Ile His Tyr Gln His Leu Met Pro Pro Pro Pro Arg
             260                 265                 270        
 Leu Pro Pro His Leu Ala Val Pro Pro Pro Gly Ala Ile Pro Pro Ala
         275                 280                 285            
 Leu His Leu Asn Pro Ala Phe Leu Pro Pro Pro Asn Ala Thr Val Gly
     290                 295                 300                
 Pro Pro Pro Asp Thr Tyr Met Lys Ala Ser Ala Pro Tyr Asn His His
 305                 310                 315                 320
 Gly Ser Arg Asp Ser Gly Pro Pro Pro Ser Thr Val Ser Glu Ala Glu
                 325                 330                 335    
 Phe Glu Asp Ile Met Lys Arg Asn Arg Ala Ile Ser Ser Ser Ala Ile
             340                 345                 350        
 Ser Lys Ala Val Ser Gly Ala Ser Ala Gly Asp Tyr Ser Asp Ala Ile
         355                 360                 365            
 Glu Thr Leu Leu Thr Ala Ile Ala Val Ile Lys Gln Ser Arg Val Ala
     370                 375                 380                
 Asn Asp Glu Arg Cys Arg Val Leu Ile Ser Ser Leu Lys Asp Cys Leu
 385                 390                 395                 400
 His Gly Ile Glu Ala Lys Ser Tyr Ser Val Gly Ala Ser Gly Ser Ser
                 405                 410                 415    
 Ser Arg
        



      <210> 167
      <211> 694
      <212> PRT
      <213> Homo sapiens


      <400> 167
 Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
   1               5                  10                  15    
 Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
              20                  25                  30        
 Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
          35                  40                  45            
 Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
      50                  55                  60                
 Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
  65                  70                  75                  80
 Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                  85                  90                  95    
 Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
             100                 105                 110        
 Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
         115                 120                 125            
 Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
     130                 135                 140                
 Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
 145                 150                 155                 160
 Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                 165                 170                 175    
 Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
             180                 185                 190        
 Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
         195                 200                 205            
 Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
     210                 215                 220                
 Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
 225                 230                 235                 240
 Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                 245                 250                 255    
 Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
             260                 265                 270        
 Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
         275                 280                 285            
 Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
     290                 295                 300                
 Tyr Val Thr Val Leu Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser
 305                 310                 315                 320
 Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
                 325                 330                 335    
 Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
             340                 345                 350        
 Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
         355                 360                 365            
 Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
     370                 375                 380                
 Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
 385                 390                 395                 400
 Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
                 405                 410                 415    
 Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
             420                 425                 430        
 Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
         435                 440                 445            
 Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
     450                 455                 460                
 Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
 465                 470                 475                 480
 Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
                 485                 490                 495    
 Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
             500                 505                 510        
 Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
         515                 520                 525            
 Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
     530                 535                 540                
 Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
 545                 550                 555                 560
 His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
                 565                 570                 575    
 Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
             580                 585                 590        
 Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
         595                 600                 605            
 His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
     610                 615                 620                
 Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
 625                 630                 635                 640
 Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
                 645                 650                 655    
 Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
             660                 665                 670        
 Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
         675                 680                 685            
 Ser Gly Gly Ser Arg Thr
     690                



      <210> 168
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 168
 Met Met Glu Thr Met Gln Leu Lys Val Asn Arg His Pro Phe Cys Phe
   1               5                  10                  15    
 Ser Val Lys Gly Gln Val Lys Met Leu Gln Leu Met Arg Leu Gly Leu
              20                  25                  30        
 Arg Val Arg Gly Val Val Glu Ser Ala Cys Gly Arg Glu Met Trp Leu
          35                  40                  45            
 Cys Gly Tyr Lys Gly
      50            



      <210> 169
      <211> 42
      <212> PRT
      <213> Homo sapiens


      <400> 169
 Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala
   1               5                  10                  15    
 Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val
              20                  25                  30        
 Ser Asn Ala Asp Leu Leu Leu Lys Val Val
          35                  40        



      <210> 170
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 170
 Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly
   1               5                  10                  15    
 Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr
              20                  25                  30        
 Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala
          35                  40                  45            
 Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp
      50                  55                  60                
 Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly
  65                  70                  75                  80
 Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp
                  85                  90                  95    
 Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys
             100                 105                 110        
 Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly
         115                 120                 125            
 Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile
     130                 135                 140                
 Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu
 145                 150                 155                 160
 Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu
                 165                 170                 175    
 His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile
             180                 185                 190        
 Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile
         195                 200                 205            
 Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn
     210                 215                 220                
 Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln
 225                 230                 235                 240
 Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly
                 245                 250                 255    
 Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu
             260                 265                 270        
 Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu
         275                 280                 285            
 Leu
    



      <210> 171
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 171
 Met Asp Ala Leu Ser Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu
   1               5                  10                  15    
 Lys Lys Leu Gly Glu Asn Asn Ser Asn Asn Leu Phe Phe Ser Pro Leu
              20                  25                  30        
 Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly Asn
          35                  40                  45            
 Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Phe Ser Lys Ile Gly Gly
      50                  55                  60                
 Glu Asp Gly Asp Ile His Arg Gly Phe Gln Ser Leu Leu Val Ala Ile
  65                  70                  75                  80
 Asn Arg Thr Asp Thr Glu Tyr Val Leu Arg Thr Ala Asn Gly Leu Phe
                  85                  90                  95    
 Gly Glu Lys Ser Tyr Asp Phe Leu Thr Gly Phe Thr Asp Ser Cys Gly
             100                 105                 110        
 Lys Phe Tyr Gln Ala Thr Ile Lys Gln Leu Asp Phe Val Asn Asp Thr
         115                 120                 125            
 Glu Lys Ser Thr Thr Arg Val Asn Ser Trp Val Ala Asp Lys Thr Lys
     130                 135                 140                
 Gly Glu Asn Ile Leu Leu Phe Tyr Phe Asp Asn Ile Leu Asn Ser Phe
 145                 150                 155                 160
 Ile Val Ser Ser Leu Gln Asn Cys Gln Ile
                 165                 170



      <210> 172
      <211> 212
      <212> PRT
      <213> Homo sapiens


      <400> 172
 Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr
   1               5                  10                  15    
 Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His
              20                  25                  30        
 Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr
          35                  40                  45            
 Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg
      50                  55                  60                
 Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr
  65                  70                  75                  80
 Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala
                  85                  90                  95    
 Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu
             100                 105                 110        
 Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu
         115                 120                 125            
 Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His
     130                 135                 140                
 Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln
 145                 150                 155                 160
 Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Gly Leu
                 165                 170                 175    
 Ser Ala Phe Lys Ser Gly Ile Glu Ala Ile Ala Thr Pro Ser Asp Ile
             180                 185                 190        
 Asp Asn Asp Phe Val Asn Asp Ile Ile Ala Arg Ala Lys Phe Tyr Lys
         195                 200                 205            
 Arg Gln Ser Phe
     210        



      <210> 173
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 173
 Met Val Phe Arg Asn Val Gly Arg Pro Pro Glu Glu Glu Asp Val Glu
   1               5                  10                  15    
 Ala Ala Pro Glu Pro Gly Pro Ser Glu Leu Leu Cys Pro Arg His Arg
              20                  25                  30        
 Cys Ala Leu Asp Pro Lys Ala Leu Pro Pro Gly Leu Ala Leu Glu Arg
          35                  40                  45            
 Thr Trp Gly Pro Ala Ala Gly Leu Glu Ala Gln Leu Ala Ala Leu Gly
      50                  55                  60                
 Leu Gly Gln Pro Ala Gly Pro Gly Val Lys Thr Val Gly Gly Gly Cys
  65                  70                  75                  80
 Cys Pro Cys Pro Cys Pro Pro Gln Pro Pro Pro Pro Gln Pro Gln Pro
                  85                  90                  95    
 Pro Ala Ala Ala Pro Gln Ala Gly Glu Asp Pro Thr Glu Thr Ser Asp
             100                 105                 110        
 Ala Leu Leu Val Leu Glu Gly Leu Glu Ser Glu Ala Glu Ser Leu Glu
         115                 120                 125            
 Thr Asn Ser Cys Ser Glu Glu Glu Leu Ser Ser Pro Gly Arg Gly Gly
     130                 135                 140                
 Gly Gly Gly Gly Arg Leu Leu Leu Gln Pro Pro Gly Pro Glu Leu Pro
 145                 150                 155                 160
 Pro Val Pro Phe Pro Leu Gln Asp Leu Val Pro Leu Gly Arg Leu Ser
                 165                 170                 175    
 Arg Gly Glu Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro
             180                 185                 190        
 Pro Pro Pro Gly Pro Leu Arg Pro Leu Ala Gly Pro Ser Arg Lys Gly
         195                 200                 205            
 Ser Phe Lys Ile Arg Leu Ser Arg Leu Phe Arg Thr Lys Ser Cys Asn
     210                 215                 220                
 Gly Gly Ser Gly Gly Gly Asp Gly Thr Gly Lys Arg Pro Ser Gly Glu
 225                 230                 235                 240
 Leu Ala Ala Ser Ala Ala Ser Leu Thr Asp Met Gly Gly Ser Ala Gly
                 245                 250                 255    
 Arg Glu Leu Asp Ala Gly Arg Lys Pro Lys Leu Thr Arg Thr Gln Ser
             260                 265                 270        
 Ala Phe Ser Pro Val Ser Phe Ser Pro Leu Phe Thr Gly Glu Thr Val
         275                 280                 285            
 Ser Leu Val Asp Val Asp Ile Ser Gln Arg Gly Leu Thr Ser Pro His
     290                 295                 300                
 Pro Pro Thr Pro Pro Pro Pro Pro Arg Arg Ser Leu Ser Leu Leu Asp
 305                 310                 315                 320
 Asp Ile Ser Gly Thr Leu Pro Thr Ser Val Leu Val Ala Pro Met Gly
                 325                 330                 335    
 Ser Ser Leu Gln Ser Phe Pro Leu Pro Pro Pro Pro Pro Pro His Ala
             340                 345                 350        
 Pro Asp Ala Phe Pro Arg Ile Ala Pro Ile Arg Ala Ala Glu Ser Leu
         355                 360                 365            
 His Ser Gln Pro Pro Gln His Leu Gln Cys Pro Leu Tyr Arg Pro Asp
     370                 375                 380                
 Ser Ser Ser Phe Ala Ala Ser Leu Arg Glu Leu Glu Lys Cys Gly Trp
 385                 390                 395                 400
 Tyr Trp Gly Pro Met Asn Trp Glu Asp Ala Glu Met Lys Leu Lys Gly
                 405                 410                 415    
 Lys Pro Asp Gly Ser Phe Leu Val Arg Asp Ser Ser Asp Pro Arg Tyr
             420                 425                 430        
 Ile Leu Ser Leu Ser Phe Arg Ser Gln Gly Ile Thr His His Thr Arg
         435                 440                 445            
 Met Glu His Tyr Arg Gly Thr Phe Ser Leu Trp Cys His Pro Lys Phe
     450                 455                 460                
 Glu Asp Arg Cys Gln Ser Val Val Glu Phe Ile Lys Arg Ala Ile Met
 465                 470                 475                 480
 His Ser Lys Asn Gly Lys Phe Leu Tyr Phe Leu Arg Ser Arg Val Pro
                 485                 490                 495    
 Gly Leu Pro Pro Thr Pro Val Gln Leu Leu Tyr Pro Val Ser Arg Phe
             500                 505                 510        
 Ser Asn Val Lys Ser Leu Gln His Leu Cys Arg Phe Arg Ile Arg Gln
         515                 520                 525            
 Leu Val Arg Ile Asp His Ile Pro Asp Leu Pro Leu Pro Lys Pro Leu
     530                 535                 540                
 Ile Ser Tyr Ile Arg Lys Phe Tyr Tyr Tyr Asp Pro Gln Glu Glu Val
 545                 550                 555                 560
 Tyr Leu Ser Leu Lys Glu Ala Gln Leu Ile Ser Lys Gln Lys Gln Glu
                 565                 570                 575    
 Val Glu Pro Ser Thr
             580    



      <210> 174
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 174
 Met His Ser Tyr Pro Gly Ile Phe Phe Phe Pro Leu Ala Val Phe Gln
   1               5                  10                  15    
 Ile Ile Ser Leu Val Ile Tyr Pro Val Lys Tyr Thr Gln Thr Phe Thr
              20                  25                  30        
 Leu His Asp Asn Pro Ala Val Asn Tyr Ile Tyr Asn Trp Ala Tyr Gly
          35                  40                  45            
 Phe Gly Trp Ala Ala Thr Ile Ile Leu Ile Gly Cys Ser Phe Phe Phe
      50                  55                  60                
 Cys Cys Leu Pro Asn Tyr Glu Asp Asp Leu Leu Gly Ala Ala Lys Pro
  65                  70                  75                  80
 Arg Tyr Phe Tyr Pro Pro Ala
                  85        



      <210> 175
      <211> 193
      <212> PRT
      <213> Homo sapiens


      <400> 175
 Met Leu Arg Cys Gly Leu Ala Cys Glu Arg Cys Arg Trp Ile Leu Pro
   1               5                  10                  15    
 Leu Leu Leu Leu Ser Ala Ile Ala Phe Asp Ile Ile Ala Leu Ala Gly
              20                  25                  30        
 Arg Gly Trp Leu Gln Ser Ser Asn His Ile Gln Thr Ser Ser Leu Trp
          35                  40                  45            
 Trp Arg Cys Phe Asp Glu Gly Gly Gly Ser Gly Ser Tyr Asp Asp Gly
      50                  55                  60                
 Cys Gln Ser Leu Met Glu Tyr Ala Trp Gly Arg Ala Ala Ala Ala Thr
  65                  70                  75                  80
 Leu Phe Cys Gly Phe Ile Ile Leu Cys Ile Cys Phe Ile Leu Ser Phe
                  85                  90                  95    
 Phe Ala Leu Cys Gly Pro Gln Met Leu Val Phe Leu Arg Val Ile Gly
             100                 105                 110        
 Gly Leu Leu Ala Leu Ala Ala Ile Phe Gln Ile Ile Ser Leu Val Ile
         115                 120                 125            
 Tyr Pro Val Lys Tyr Thr Gln Thr Phe Thr Leu His Asp Asn Pro Ala
     130                 135                 140                
 Val Asn Tyr Ile Tyr Asn Trp Ala Tyr Gly Phe Gly Trp Ala Ala Thr
 145                 150                 155                 160
 Ile Ile Leu Ile Gly Cys Ser Phe Phe Phe Cys Cys Leu Pro Asn Tyr
                 165                 170                 175    
 Glu Asp Asp Leu Leu Gly Ala Ala Lys Pro Arg Tyr Phe Tyr Pro Pro
             180                 185                 190        
 Ala
    



      <210> 176
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 176
 Met Gly Leu Met Phe Leu Pro Cys Leu Ile Asn Leu Phe Gln Arg Phe
   1               5                  10                  15    
 Phe Lys Leu Thr Gly Ser Trp Pro Phe His Arg Gln Leu Pro Lys Asn
              20                  25                  30        
 Ile Tyr Arg Arg His Cys Ser Tyr Gln His Asp Thr Arg Glu Leu Ser
          35                  40                  45            
 Val Pro Ser Ser Ala Gly Ser Ser Gln Lys Glu His Ala Ala Pro Arg
      50                  55                  60                
 Pro Phe Tyr Asn Tyr Glu Val Trp Ile Asp Arg Ala Glu Ala Ser Pro
  65                  70                  75                  80
 Leu Trp Ile Ser Ala Ser Phe
                  85        



      <210> 177
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 177
 Met Ser Leu Leu Arg Leu His Arg Leu Ser Ile Ile Trp Lys Asn Leu
   1               5                  10                  15    
 Ile Phe His Gln Glu Tyr Glu His Val Phe Gln Val Glu Asn Ala Lys
              20                  25                  30        
 Asp Asn Glu Asp Ser Ile Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser
          35                  40                  45            
 Arg Arg Arg Phe Arg Lys Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile
      50                  55                  60                
 Thr Asp Asp Val Glu Val Asn Ser Tyr Leu Ser Val Ser Ile Phe Arg
  65                  70                  75                  80
 Asn Thr Ser
            



      <210> 178
      <211> 662
      <212> PRT
      <213> Homo sapiens


      <400> 178
 Met Lys Glu Val Thr Phe His Cys His Glu Gly Tyr Ile Leu His Gly
   1               5                  10                  15    
 Ala Pro Lys Leu Thr Cys Gln Ser Asp Gly Asn Trp Asp Ala Glu Ile
              20                  25                  30        
 Pro Leu Cys Lys Pro Val Asn Cys Gly Pro Pro Glu Asp Leu Ala His
          35                  40                  45            
 Gly Phe Pro Asn Gly Phe Ser Phe Ile His Gly Gly His Ile Gln Tyr
      50                  55                  60                
 Gln Cys Phe Pro Gly Tyr Lys Leu His Gly Asn Ser Ser Arg Arg Cys
  65                  70                  75                  80
 Leu Ser Asn Gly Ser Trp Ser Gly Ser Ser Pro Ser Cys Leu Pro Cys
                  85                  90                  95    
 Arg Cys Ser Thr Pro Val Ile Glu Tyr Gly Thr Val Asn Gly Thr Asp
             100                 105                 110        
 Phe Asp Cys Gly Lys Ala Ala Arg Ile Gln Cys Phe Lys Gly Phe Lys
         115                 120                 125            
 Leu Leu Gly Leu Ser Glu Ile Thr Cys Glu Ala Asp Gly Gln Trp Ser
     130                 135                 140                
 Ser Gly Phe His His Phe Glu His Thr Ser Cys Gly Ser Leu Pro Met
 145                 150                 155                 160
 Ile Pro Asn Ala Phe Ile Ser Glu Thr Ser Ser Trp Lys Glu Asn Val
                 165                 170                 175    
 Ile Thr Tyr Ser Cys Arg Ser Gly Tyr Val Ile Gln Gly Ser Ser Asp
             180                 185                 190        
 Leu Ile Cys Thr Glu Lys Gly Val Trp Ser Gln Pro Tyr Pro Val Cys
         195                 200                 205            
 Glu Pro Leu Ser Cys Gly Ser Pro Pro Ser Val Ala Asn Ala Val Ala
     210                 215                 220                
 Thr Gly Glu Ala His Thr Tyr Glu Ser Glu Val Lys Leu Arg Cys Leu
 225                 230                 235                 240
 Glu Gly Tyr Thr Met Asp Thr Asp Thr Arg Ser Ile Thr Cys Gln Lys
                 245                 250                 255    
 Asp Gly Arg Trp Phe Pro Glu Arg Ile Ser Cys Ser Pro Lys Lys Cys
             260                 265                 270        
 Pro Leu Pro Glu Asn Ile Thr His Ile Leu Val His Gly Asp Asp Phe
         275                 280                 285            
 Ser Val Asn Arg Gln Val Ser Val Ser Cys Ala Glu Gly Tyr Thr Phe
     290                 295                 300                
 Glu Gly Val Asn Ile Ser Val Cys Gln Leu Asp Gly Thr Trp Glu Pro
 305                 310                 315                 320
 Pro Phe Ser Asp Glu Ser Cys Ser Pro Val Ser Cys Gly Lys Pro Glu
                 325                 330                 335    
 Ser Pro Glu His Gly Phe Val Val Gly Ser Lys Tyr Thr Phe Glu Ser
             340                 345                 350        
 Thr Ile Ile Tyr Gln Cys Glu Pro Gly Tyr Glu Leu Glu Gly Asn Arg
         355                 360                 365            
 Glu Arg Val Cys Gln Glu Asn Arg Gln Trp Ser Gly Gly Val Ala Ile
     370                 375                 380                
 Cys Lys Glu Thr Arg Cys Glu Thr Pro Leu Glu Phe Leu Asn Gly Lys
 385                 390                 395                 400
 Ala Asp Ile Glu Asn Arg Thr Thr Gly Pro Asn Val Val Tyr Ser Cys
                 405                 410                 415    
 Asn Arg Gly Tyr Ser Leu Glu Gly Pro Ser Glu Ala His Cys Thr Glu
             420                 425                 430        
 Asn Gly Thr Trp Ser His Pro Val Pro Leu Cys Lys Pro Asn Pro Cys
         435                 440                 445            
 Pro Val Pro Phe Val Ile Pro Glu Asn Ala Leu Leu Ser Glu Lys Glu
     450                 455                 460                
 Phe Tyr Val Asp Gln Asn Val Ser Ile Lys Cys Arg Glu Gly Phe Leu
 465                 470                 475                 480
 Leu Gln Gly His Gly Ile Ile Thr Cys Asn Pro Asp Glu Thr Trp Thr
                 485                 490                 495    
 Gln Thr Ser Ala Lys Cys Glu Lys Ile Ser Cys Gly Pro Pro Ala His
             500                 505                 510        
 Val Glu Asn Ala Ile Ala Arg Gly Val His Tyr Gln Tyr Gly Asp Met
         515                 520                 525            
 Ile Thr Tyr Ser Cys Tyr Ser Gly Tyr Met Leu Glu Gly Phe Leu Arg
     530                 535                 540                
 Ser Val Cys Leu Glu Asn Gly Thr Trp Thr Ser Pro Pro Ile Cys Arg
 545                 550                 555                 560
 Ala Val Cys Arg Phe Pro Cys Gln Asn Gly Gly Ile Cys Gln Arg Pro
                 565                 570                 575    
 Asn Ala Cys Ser Cys Pro Glu Gly Trp Met Gly Arg Leu Cys Glu Glu
             580                 585                 590        
 Leu Ile Cys Ile Leu Pro Cys Leu Asn Gly Gly Arg Cys Val Ala Pro
         595                 600                 605            
 Tyr Gln Cys Asp Cys Pro Pro Gly Trp Thr Gly Ser Arg Cys His Thr
     610                 615                 620                
 Ala Val Cys Gln Ser Pro Cys Leu Asn Gly Gly Lys Cys Val Arg Pro
 625                 630                 635                 640
 Asn Arg Cys His Cys Leu Ser Ser Trp Thr Gly His Asn Cys Ser Arg
                 645                 650                 655    
 Lys Arg Arg Thr Gly Phe
             660        



      <210> 179
      <211> 1867
      <212> PRT
      <213> Homo sapiens


      <400> 179
 Met Ala Arg Leu Ala Asp Tyr Phe Val Leu Val Ala Phe Gly Pro His
   1               5                  10                  15    
 Pro Arg Gly Ser Gly Glu Gly Gln Gly Gln Ile Leu Gln Arg Phe Pro
              20                  25                  30        
 Glu Lys Asp Trp Glu Asp Asn Pro Phe Pro Gln Gly Ile Glu Leu Phe
          35                  40                  45            
 Cys Gln Pro Ser Gly Trp Gln Leu Cys Pro Glu Arg Asn Pro Pro Thr
      50                  55                  60                
 Phe Phe Val Ala Val Leu Thr Asp Ile Asn Ser Glu Arg His Tyr Cys
  65                  70                  75                  80
 Ala Cys Leu Thr Phe Trp Glu Pro Ala Glu Pro Ser Gln Glu Thr Thr
                  85                  90                  95    
 Arg Val Glu Asp Ala Thr Glu Arg Glu Glu Glu Gly Asp Glu Gly Gly
             100                 105                 110        
 Gln Thr His Leu Ser Pro Thr Ala Pro Ala Pro Ser Ala Gln Leu Phe
         115                 120                 125            
 Ala Pro Lys Thr Leu Val Leu Val Ser Arg Leu Asp His Thr Glu Val
     130                 135                 140                
 Phe Arg Asn Ser Leu Gly Leu Ile Tyr Ala Ile His Val Glu Gly Leu
 145                 150                 155                 160
 Asn Val Cys Leu Glu Asn Val Ile Gly Asn Leu Leu Thr Cys Thr Val
                 165                 170                 175    
 Pro Leu Ala Gly Gly Ser Gln Arg Thr Ile Ser Leu Gly Ala Gly Asp
             180                 185                 190        
 Arg Gln Val Ile Gln Thr Pro Leu Ala Asp Ser Leu Pro Val Ser Arg
         195                 200                 205            
 Cys Ser Val Ala Leu Leu Phe Arg Gln Leu Gly Ile Thr Asn Val Leu
     210                 215                 220                
 Ser Leu Phe Cys Ala Ala Leu Thr Glu His Lys Val Leu Phe Leu Ser
 225                 230                 235                 240
 Arg Ser Tyr Gln Arg Leu Ala Asp Ala Cys Arg Gly Leu Leu Ala Leu
                 245                 250                 255    
 Leu Phe Pro Leu Arg Tyr Ser Phe Thr Tyr Val Pro Ile Leu Pro Ala
             260                 265                 270        
 Gln Leu Leu Glu Val Leu Ser Thr Pro Thr Pro Phe Ile Ile Gly Val
         275                 280                 285            
 Asn Ala Ala Phe Gln Ala Glu Thr Gln Glu Leu Leu Asp Val Ile Val
     290                 295                 300                
 Ala Asp Leu Asp Gly Gly Thr Val Thr Ile Pro Glu Cys Val His Ile
 305                 310                 315                 320
 Pro Pro Leu Pro Glu Pro Leu Gln Ser Gln Thr His Ser Val Leu Ser
                 325                 330                 335    
 Met Val Leu Asp Pro Glu Leu Glu Leu Ala Asp Leu Ala Phe Pro Pro
             340                 345                 350        
 Pro Thr Thr Ser Thr Ser Ser Leu Lys Met Gln Asp Lys Glu Leu Arg
         355                 360                 365            
 Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Leu Gln Gly Tyr Arg Trp
     370                 375                 380                
 Cys Leu His Val Val Arg Ile His Pro Glu Pro Val Ile Arg Phe His
 385                 390                 395                 400
 Lys Ala Ala Phe Leu Gly Gln Arg Gly Leu Val Glu Asp Asp Phe Leu
                 405                 410                 415    
 Met Lys Val Leu Glu Gly Met Ala Phe Ala Gly Phe Val Ser Glu Arg
             420                 425                 430        
 Gly Val Pro Tyr Arg Pro Thr Asp Leu Phe Asp Glu Leu Val Ala His
         435                 440                 445            
 Glu Val Ala Arg Met Arg Ala Asp Glu Asn His Pro Gln Arg Val Leu
     450                 455                 460                
 Arg His Val Gln Glu Leu Ala Glu Gln Leu Tyr Lys Asn Glu Asn Pro
 465                 470                 475                 480
 Tyr Pro Ala Val Ala Met His Lys Val Gln Arg Pro Gly Glu Ser Ser
                 485                 490                 495    
 His Leu Arg Arg Val Pro Arg Pro Phe Pro Arg Leu Asp Glu Gly Thr
             500                 505                 510        
 Val Gln Trp Ile Val Asp Gln Ala Ala Ala Lys Met Gln Gly Ala Pro
         515                 520                 525            
 Pro Ala Val Lys Ala Glu Arg Arg Thr Thr Val Pro Ser Gly Pro Pro
     530                 535                 540                
 Met Thr Ala Ile Leu Glu Arg Cys Ser Gly Leu His Val Asn Ser Ala
 545                 550                 555                 560
 Arg Arg Leu Glu Val Val Arg Asn Cys Ile Ser Tyr Val Phe Glu Gly
                 565                 570                 575    
 Lys Met Leu Glu Ala Lys Lys Leu Leu Pro Ala Val Leu Arg Ala Leu
             580                 585                 590        
 Lys Gly Arg Val Ala Arg Arg Cys Leu Ala Gln Glu Leu His Leu His
         595                 600                 605            
 Val Gln Gln Asn Arg Ala Val Leu Asp His Gln Gln Phe Asp Phe Val
     610                 615                 620                
 Val Arg Met Met Asn Cys Cys Leu Gln Asp Cys Thr Ser Leu Asp Glu
 625                 630                 635                 640
 His Gly Ile Ala Ala Ala Leu Leu Pro Leu Val Thr Ala Phe Cys Arg
                 645                 650                 655    
 Lys Leu Ser Pro Gly Val Thr Gln Phe Ala Tyr Ser Cys Val Gln Glu
             660                 665                 670        
 His Val Val Trp Ser Thr Pro Gln Phe Trp Glu Ala Met Phe Tyr Gly
         675                 680                 685            
 Asp Val Gln Thr His Ile Arg Ala Leu Tyr Leu Glu Pro Thr Glu Asp
     690                 695                 700                
 Leu Ala Pro Ala Gln Glu Val Gly Glu Ala Pro Ser Gln Glu Asp Glu
 705                 710                 715                 720
 Arg Ser Ala Leu Asp Val Ala Ser Glu Gln Arg Arg Leu Trp Pro Thr
                 725                 730                 735    
 Leu Ser Arg Glu Lys Gln Gln Glu Leu Val Gln Lys Glu Glu Ser Thr
             740                 745                 750        
 Val Phe Ser Gln Ala Ile His Tyr Ala Asn Arg Met Ser Tyr Leu Leu
         755                 760                 765            
 Leu Pro Leu Asp Ser Ser Lys Ser Arg Leu Leu Arg Glu Arg Ala Gly
     770                 775                 780                
 Leu Gly Asp Leu Glu Ser Ala Ser Asn Ser Leu Val Thr Asn Ser Met
 785                 790                 795                 800
 Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu Ser Gly Phe Glu Asp
                 805                 810                 815    
 Ala Glu Thr Cys Asp Val Ala Gly Ala Val Val Arg Phe Ile Asn Arg
             820                 825                 830        
 Phe Val Asp Lys Val Cys Thr Glu Ser Gly Val Thr Ser Asp His Leu
         835                 840                 845            
 Lys Gly Leu His Val Met Val Pro Asp Ile Val Gln Met His Ile Glu
     850                 855                 860                
 Thr Leu Glu Ala Val Gln Arg Glu Ser Arg Arg Leu Pro Pro Ile Gln
 865                 870                 875                 880
 Lys Pro Lys Leu Leu Arg Pro Arg Leu Leu Pro Gly Glu Glu Cys Val
                 885                 890                 895    
 Leu Asp Gly Leu Arg Val Tyr Leu Leu Pro Asp Gly Arg Glu Glu Gly
             900                 905                 910        
 Ala Gly Gly Ser Ala Gly Gly Pro Ala Leu Leu Pro Ala Glu Gly Ala
         915                 920                 925            
 Val Phe Leu Thr Thr Tyr Arg Val Ile Phe Thr Gly Met Pro Thr Asp
     930                 935                 940                
 Pro Leu Val Gly Glu Gln Val Val Val Arg Ser Phe Pro Val Ala Ala
 945                 950                 955                 960
 Leu Thr Lys Glu Lys Arg Ile Ser Val Gln Thr Pro Val Asp Gln Leu
                 965                 970                 975    
 Leu Gln Asp Gly Leu Gln Leu Arg Ser Cys Thr Phe Gln Leu Leu Lys
             980                 985                 990        
 Met Ala Phe Asp Glu Glu Val Gly Ser Asp Ser Ala Glu Leu Phe Arg
         995                1000                1005            
 Lys Gln Leu His Lys Leu Arg Tyr Pro Pro Asp Ile Arg Ala Thr Phe
    1010                1015                1020                
 Ala Phe Thr Leu Gly Ser Ala His Thr Pro Gly Arg Pro Pro Arg Val
1025                1030                1035                1040
 Thr Lys Asp Lys Gly Pro Ser Leu Arg Thr Leu Ser Arg Asn Leu Val
                1045                1050                1055    
 Lys Asn Ala Lys Lys Thr Ile Gly Arg Gln His Val Thr Arg Lys Lys
            1060                1065                1070        
 Tyr Asn Pro Pro Ser Trp Glu His Arg Gly Gln Pro Pro Pro Glu Asp
        1075                1080                1085            
 Gln Glu Asp Glu Ile Ser Val Ser Glu Glu Leu Glu Pro Ser Thr Leu
    1090                1095                1100                
 Thr Pro Ser Ser Ala Leu Lys Pro Ser Asp Arg Met Thr Met Ser Ser
1105                1110                1115                1120
 Leu Val Glu Arg Ala Cys Cys Arg Asp Tyr Gln Arg Leu Gly Leu Gly
                1125                1130                1135    
 Thr Leu Ser Ser Ser Leu Ser Arg Ala Lys Ser Glu Pro Phe Arg Ile
            1140                1145                1150        
 Ser Pro Val Asn Arg Met Tyr Ala Ile Cys Arg Ser Tyr Pro Gly Leu
        1155                1160                1165            
 Leu Ile Val Arg Gln Ser Val Gln Asp Asn Ala Leu Gln Arg Val Ser
    1170                1175                1180                
 Arg Cys Tyr Arg Gln Asn Arg Phe Pro Val Val Cys Trp Arg Ser Gly
1185                1190                1195                1200
 Arg Ser Lys Ala Val Leu Leu Arg Ser Gly Gly Leu His Gly Lys Gly
                1205                1210                1215    
 Val Val Gly Leu Phe Lys Ala Gln Asn Ala Pro Ser Pro Gly Gln Ser
            1220                1225                1230        
 Gln Ala Asp Ser Ser Ser Leu Glu Gln Glu Lys Tyr Leu Gln Ala Val
        1235                1240                1245            
 Val Ser Ser Met Pro Arg Tyr Ala Asp Ala Ser Gly Arg Asn Thr Leu
    1250                1255                1260                
 Ser Gly Phe Ser Ser Ala His Met Gly Ser His Gly Lys Trp Gly Ser
1265                1270                1275                1280
 Val Arg Thr Ser Gly Arg Ser Ser Gly Leu Gly Thr Asp Val Gly Ser
                1285                1290                1295    
 Arg Leu Ala Gly Arg Asp Ala Leu Ala Pro Pro Gln Ala Asn Gly Gly
            1300                1305                1310        
 Pro Pro Asp Pro Gly Phe Leu Arg Pro Gln Arg Ala Ala Leu Tyr Ile
        1315                1320                1325            
 Leu Gly Asp Lys Ala Gln Leu Lys Gly Val Arg Ser Asp Pro Leu Gln
    1330                1335                1340                
 Gln Trp Glu Leu Val Pro Ile Glu Val Phe Glu Ala Arg Gln Val Lys
1345                1350                1355                1360
 Ala Ser Phe Lys Lys Leu Leu Lys Ala Cys Val Pro Gly Cys Pro Ala
                1365                1370                1375    
 Ala Glu Pro Ser Pro Ala Ser Phe Leu Arg Ser Leu Glu Asp Ser Glu
            1380                1385                1390        
 Trp Leu Ile Gln Ile His Lys Leu Leu Gln Val Ser Val Leu Val Val
        1395                1400                1405            
 Glu Leu Leu Asp Ser Gly Ser Ser Val Leu Val Gly Leu Glu Asp Gly
    1410                1415                1420                
 Trp Asp Ile Thr Thr Gln Val Val Ser Leu Val Gln Leu Leu Ser Asp
1425                1430                1435                1440
 Pro Phe Tyr Arg Thr Leu Glu Gly Phe Arg Leu Leu Val Glu Lys Glu
                1445                1450                1455    
 Trp Leu Ser Phe Gly His Arg Phe Ser His Arg Gly Ala His Thr Leu
            1460                1465                1470        
 Ala Gly Gln Ser Ser Gly Phe Thr Pro Val Phe Leu Gln Phe Leu Asp
        1475                1480                1485            
 Cys Val His Gln Val His Leu Gln Phe Pro Met Glu Phe Glu Phe Ser
    1490                1495                1500                
 Gln Phe Tyr Leu Lys Phe Leu Gly Tyr His His Val Ser Arg Arg Phe
1505                1510                1515                1520
 Arg Thr Phe Leu Leu Asp Ser Asp Tyr Glu Arg Ile Glu Leu Gly Leu
                1525                1530                1535    
 Leu Tyr Glu Glu Lys Gly Glu Arg Arg Gly Gln Val Pro Cys Arg Ser
            1540                1545                1550        
 Val Trp Glu Tyr Val Asp Arg Leu Ser Lys Arg Thr Pro Val Phe His
        1555                1560                1565            
 Asn Tyr Met Tyr Ala Pro Glu Asp Ala Glu Val Leu Arg Pro Tyr Ser
    1570                1575                1580                
 Asn Val Ser Asn Leu Lys Val Trp Asp Phe Tyr Thr Glu Glu Thr Leu
1585                1590                1595                1600
 Ala Glu Gly Pro Pro Tyr Asp Trp Glu Leu Ala Gln Gly Pro Pro Glu
                1605                1610                1615    
 Pro Pro Glu Glu Glu Arg Ser Asp Gly Gly Ala Pro Gln Ser Arg Arg
            1620                1625                1630        
 Arg Val Val Trp Pro Cys Tyr Asp Ser Cys Pro Arg Ala Gln Pro Asp
        1635                1640                1645            
 Ala Ile Ser Arg Leu Leu Glu Glu Leu Gln Arg Leu Glu Thr Glu Leu
    1650                1655                1660                
 Gly Gln Pro Ala Glu Arg Trp Lys Asp Thr Trp Asp Arg Val Lys Ala
1665                1670                1675                1680
 Ala Gln Arg Leu Glu Gly Arg Pro Asp Gly Arg Gly Thr Pro Ser Ser
                1685                1690                1695    
 Leu Leu Val Ser Thr Ala Pro His His Arg Arg Ser Leu Gly Val Tyr
            1700                1705                1710        
 Leu Gln Glu Gly Pro Val Gly Ser Thr Leu Ser Leu Ser Leu Asp Ser
        1715                1720                1725            
 Asp Gln Ser Ser Gly Ser Thr Thr Ser Gly Ser Arg Gln Ala Ala Arg
    1730                1735                1740                
 Arg Ser Thr Ser Thr Leu Tyr Ser Gln Phe Gln Thr Ala Glu Ser Glu
1745                1750                1755                1760
 Asn Arg Ser Tyr Glu Gly Thr Leu Tyr Lys Lys Gly Ala Phe Met Lys
                1765                1770                1775    
 Pro Trp Lys Ala Arg Trp Phe Val Leu Asp Lys Thr Lys His Gln Leu
            1780                1785                1790        
 Arg Tyr Tyr Asp His Arg Val Asp Thr Glu Cys Lys Gly Val Ile Asp
        1795                1800                1805            
 Leu Ala Glu Val Glu Ala Val Ala Pro Gly Thr Pro Thr Met Gly Ala
    1810                1815                1820                
 Pro Lys Thr Val Asp Glu Lys Ala Phe Phe Asp Val Lys Thr Thr Arg
1825                1830                1835                1840
 Arg Val Tyr Asn Phe Cys Ala Gln Asp Val Pro Ser Ala Gln Gln Trp
                1845                1850                1855    
 Val Asp Arg Ile Gln Ser Cys Leu Ser Asp Ala
            1860                1865        



      <210> 180
      <211> 495
      <212> PRT
      <213> Homo sapiens


      <400> 180
 Met Glu Tyr Phe Asp Leu Lys Arg His Glu Leu Cys Gly Asp Tyr Ile
   1               5                  10                  15    
 Lys Asp Ile Leu Cys Gln Glu Cys Ser Pro Tyr Ala Ala His Leu Tyr
              20                  25                  30        
 Asp Ala Glu Asn Thr Gln Thr Pro Leu Arg Asn Leu Pro Gly Leu Cys
          35                  40                  45            
 Ser Asp Tyr Cys Ser Ala Phe His Ser Asn Cys His Ser Ala Ile Ser
      50                  55                  60                
 Leu Leu Thr Asn Asp Arg Gly Leu Gln Glu Ser His Gly Arg Asp Gly
  65                  70                  75                  80
 Thr Arg Phe Cys His Leu Leu Asp Leu Pro Asp Lys Asp Tyr Cys Phe
                  85                  90                  95    
 Pro Asn Val Leu Arg Asn Asp Tyr Leu Asn Arg His Leu Gly Met Val
             100                 105                 110        
 Ala Gln Asp Pro Gln Gly Cys Leu Gln Leu Cys Leu Ser Glu Val Ala
         115                 120                 125            
 Asn Gly Leu Arg Asn Pro Val Ser Met Val His Ala Gly Asp Gly Thr
     130                 135                 140                
 His Arg Phe Phe Val Ala Glu Gln Val Gly Val Val Trp Val Tyr Leu
 145                 150                 155                 160
 Pro Asp Gly Ser Arg Leu Glu Gln Pro Phe Leu Asp Leu Lys Asn Ile
                 165                 170                 175    
 Val Leu Thr Thr Pro Trp Ile Gly Asp Glu Arg Gly Phe Leu Gly Leu
             180                 185                 190        
 Ala Phe His Pro Lys Phe Arg His Asn Arg Lys Phe Tyr Ile Tyr Tyr
         195                 200                 205            
 Ser Cys Leu Asp Lys Lys Lys Val Glu Lys Ile Arg Ile Ser Glu Met
     210                 215                 220                
 Lys Val Ser Arg Ala Asp Pro Asn Lys Ala Asp Leu Lys Ser Glu Arg
 225                 230                 235                 240
 Val Ile Leu Glu Ile Glu Glu Pro Ala Ser Asn His Asn Gly Gly Gln
                 245                 250                 255    
 Leu Leu Phe Gly Leu Asp Gly Tyr Met Tyr Ile Phe Thr Gly Asp Gly
             260                 265                 270        
 Gly Gln Ala Gly Asp Pro Phe Gly Leu Phe Gly Asn Ala Gln Asn Lys
         275                 280                 285            
 Ser Ser Leu Leu Gly Lys Val Leu Arg Ile Asp Val Asn Arg Ala Gly
     290                 295                 300                
 Ser His Gly Lys Arg Tyr Arg Val Pro Ser Asp Asn Pro Phe Val Ser
 305                 310                 315                 320
 Glu Pro Gly Ala His Pro Ala Ile Tyr Ala Tyr Gly Ile Arg Asn Met
                 325                 330                 335    
 Trp Arg Cys Ala Val Asp Arg Gly Asp Pro Ile Thr Arg Gln Gly Arg
             340                 345                 350        
 Gly Arg Ile Phe Cys Gly Asp Val Gly Gln Asn Arg Phe Glu Glu Val
         355                 360                 365            
 Asp Leu Ile Leu Lys Gly Gly Asn Tyr Gly Trp Arg Ala Lys Glu Gly
     370                 375                 380                
 Phe Ala Cys Tyr Asp Lys Lys Leu Cys His Asn Ala Ser Leu Glu Glu
 385                 390                 395                 400
 Gln Ala Thr Glu Asp Gly Ser Pro Glu Ser Leu Gly Arg Pro Ala Ser
                 405                 410                 415    
 Gly Val Pro Ile Ser Gly Val Val Leu Asp Thr Gly Val Ser Gly Arg
             420                 425                 430        
 Gly Glu Ala Pro Pro Pro Pro Ala Ala Phe Thr Lys Gly Asp Asp Glu
         435                 440                 445            
 Leu Ala Met Gly Ala Asp Gln Pro Trp Glu Gly Thr Gly Arg Gly Ala
     450                 455                 460                
 Ala Gln Ala Lys Ile Leu Leu Leu Pro Phe Leu Val Phe Ser Ile Phe
 465                 470                 475                 480
 Leu Gln Ser His Lys Ser Thr Arg Gln Lys Ile Asn Pro Tyr Val
                 485                 490                 495



      <210> 181
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 181
 Met Ile Thr Ile Ala Lys Glu Thr Gly Leu Gly Leu Lys Val Leu Gly
   1               5                  10                  15    
 Gly Ile Asn Arg Asn Glu Gly Pro Leu Val Tyr Ile Gln Glu Ile Ile
              20                  25                  30        
 Pro Gly Gly Asp Cys Tyr Lys Asp Gly Arg Leu Lys Pro Gly Asp Gln
          35                  40                  45            
 Leu Val Ser Val Asn Lys Glu Ser Met Ile Gly Val Ser Phe Glu Glu
      50                  55                  60                
 Ala Lys Ser Ile Ile Thr Arg Ala Lys Leu Arg Leu Glu Ser Ala Trp
  65                  70                  75                  80
 Glu Ile Ala Phe Ile Arg Gln Lys Ser Asp Asn Ile Gln Pro Glu Asn
                  85                  90                  95    
 Leu Ser Cys Thr Ser Leu Ile Glu Ala Ser Gly Glu Tyr Gly Pro Gln
             100                 105                 110        
 Ala Ser Thr Leu Ser Leu Phe Ser Ser Pro Pro Glu Ile Leu Ile Pro
         115                 120                 125            
 Lys Thr Ser Ser Thr Pro Lys Thr Asn Asn Asp Ile Leu Ser Ser Cys
     130                 135                 140                
 Glu Ile Lys Thr Gly Tyr Asn Lys Thr Val Gln Ile Pro Ile Thr Ser
 145                 150                 155                 160
 Glu Asn Ser Thr Val Gly Leu Ser Asn Thr Gly Ser Lys Leu Ser Trp
                 165                 170                 175    
 Tyr Ser Ala His Lys Gly Thr Thr Pro Ser Pro Glu Thr Ala Ser Thr
             180                 185                 190        
 Ser Arg Leu Lys Arg Asp Ser Val Phe Trp Arg Phe Cys Pro Gly Cys
         195                 200                 205            
 Gln Lys Leu Val Leu Leu Ala Val Gly
     210                 215        



      <210> 182
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 182
 Met Gly Leu Ile Phe Ala Lys Leu Trp Ser Leu Phe Cys Asn Gln Glu
   1               5                  10                  15    
 His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile
              20                  25                  30        
 Leu Tyr Gln Phe Leu Met Asn Glu Val Val His Thr Ser Pro Thr Ile
          35                  40                  45            
 Gly Ser Asn Val Glu Glu Ile Val Val Lys Asn Thr His Phe Leu Met
      50                  55                  60                
 Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr
  65                  70                  75                  80
 Tyr Ser Asn Thr Glu Phe Ile Ile Leu Val Val Asp Ser Ile Asp Arg
                  85                  90                  95    
 Glu Arg Leu Ala Ile Thr Lys Glu Glu Leu Tyr Arg Met Leu Ala His
             100                 105                 110        
 Glu Asp Leu Arg Lys Ala Ala Val Leu Ile Phe Ala Asn Lys Gln Asp
         115                 120                 125            
 Met Lys Gly Cys Met Thr Ala Ala Glu Ile Ser Lys Tyr Leu Thr Leu
     130                 135                 140                
 Ser Ser Ile Lys Asp His Pro Trp His Ile Gln Ser Cys Cys Ala Leu
 145                 150                 155                 160
 Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Thr Ser Arg Ile
                 165                 170                 175    
 Gly Val Arg
            



      <210> 183
      <211> 1364
      <212> PRT
      <213> Homo sapiens


      <400> 183
 Met Gly Pro Asp Glu Ala Thr Pro Pro Asp Leu Val Leu Pro Ala Trp
   1               5                  10                  15    
 Arg Leu Arg His Gly Ala Phe Arg Thr Leu Val Thr Arg Glu Pro Gly
              20                  25                  30        
 Ala Pro Arg Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala
          35                  40                  45            
 Leu Ala Ala Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val
      50                  55                  60                
 Glu Pro Ser Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro
  65                  70                  75                  80
 Thr Ser Ser Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val
                  85                  90                  95    
 Phe Pro Ser Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys
             100                 105                 110        
 Ser Thr Trp Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe
         115                 120                 125            
 Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala
     130                 135                 140                
 Ala Tyr Glu Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser
 145                 150                 155                 160
 Arg Pro Val Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu
                 165                 170                 175    
 Glu Ala Ser Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu
             180                 185                 190        
 Pro Tyr Ser Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile
         195                 200                 205            
 Lys Val Ser Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp
     210                 215                 220                
 Ser Ala Leu Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly
 225                 230                 235                 240
 Leu Cys Gly Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala
                 245                 250                 255    
 His Ser Glu Cys His Leu Asp Ala Arg Leu Thr Pro Leu Gln Phe Gly
             260                 265                 270        
 Asn Leu Gln Lys Leu Asp Gly Pro Thr Glu Gln Cys Pro Asp Pro Leu
         275                 280                 285            
 Pro Leu Pro Ala Gly Asn Cys Thr Asp Glu Glu Gly Ile Cys His Arg
     290                 295                 300                
 Thr Leu Leu Gly Pro Ala Phe Ala Glu Cys His Ala Leu Val Asp Ser
 305                 310                 315                 320
 Thr Ala Tyr Leu Ala Ala Cys Ala Gln Asp Leu Cys Arg Cys Pro Thr
                 325                 330                 335    
 Cys Pro Cys Ala Thr Phe Val Glu Tyr Ser Arg Gln Cys Ala His Ala
             340                 345                 350        
 Gly Gly Gln Pro Arg Asn Trp Arg Cys Pro Glu Leu Cys Pro Arg Thr
         355                 360                 365            
 Cys Pro Leu Asn Met Gln His Gln Glu Cys Gly Ser Pro Cys Thr Asp
     370                 375                 380                
 Thr Cys Ser Asn Pro Gln Arg Ala Gln Leu Cys Glu Asp His Cys Val
 385                 390                 395                 400
 Asp Gly Cys Phe Cys Pro Pro Gly Thr Val Leu Asp Asp Ile Thr His
                 405                 410                 415    
 Ser Gly Cys Leu Pro Leu Gly Gln Cys Pro Cys Thr His Gly Gly Arg
             420                 425                 430        
 Thr Tyr Ser Pro Gly Thr Ser Phe Asn Thr Thr Cys Ser Ser Cys Thr
         435                 440                 445            
 Cys Ser Gly Gly Leu Trp Gln Cys Gln Asp Leu Pro Cys Pro Gly Thr
     450                 455                 460                
 Cys Ser Val Gln Gly Gly Ala His Ile Ser Thr Tyr Asp Glu Lys Leu
 465                 470                 475                 480
 Tyr Asp Leu His Gly Asp Cys Ser Tyr Val Leu Ser Lys Lys Cys Ala
                 485                 490                 495    
 Asp Ser Ser Phe Thr Val Leu Ala Glu Leu Arg Lys Cys Gly Leu Thr
             500                 505                 510        
 Asp Asn Glu Asn Cys Leu Lys Ala Val Thr Leu Ser Leu Asp Gly Gly
         515                 520                 525            
 Asp Thr Ala Ile Arg Val Gln Ala Asp Gly Gly Val Phe Leu Asn Ser
     530                 535                 540                
 Ile Tyr Thr Gln Leu Pro Leu Ser Ala Ala Asn Ile Thr Leu Phe Thr
 545                 550                 555                 560
 Pro Ser Ser Phe Phe Ile Val Val Gln Thr Gly Leu Gly Leu Gln Leu
                 565                 570                 575    
 Leu Val Gln Leu Val Pro Leu Met Gln Val Phe Val Arg Leu Asp Pro
             580                 585                 590        
 Ala His Gln Gly Gln Met Cys Gly Leu Cys Gly Asn Phe Asn Gln Asn
         595                 600                 605            
 Gln Ala Asp Asp Phe Thr Ala Leu Ser Gly Val Val Glu Ala Thr Gly
     610                 615                 620                
 Ala Ala Phe Ala Asn Thr Trp Lys Ala Gln Ala Ala Cys Ala Asn Ala
 625                 630                 635                 640
 Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn Glu Asn
                 645                 650                 655    
 Tyr Ala Arg His Trp Cys Ser Arg Leu Thr Asp Pro Asn Ser Ala Phe
             660                 665                 670        
 Ser Arg Cys His Ser Ile Ile Asn Pro Lys Pro Phe His Ser Asn Cys
         675                 680                 685            
 Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu Cys Ala
     690                 695                 700                
 Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val Gln Leu
 705                 710                 715                 720
 Ser Asp Trp Arg Asp Gly Val Cys Thr Lys Tyr Met Gln Asn Cys Pro
                 725                 730                 735    
 Lys Ser Gln Arg Tyr Ala Tyr Val Val Asp Ala Cys Gln Pro Thr Cys
             740                 745                 750        
 Arg Gly Leu Ser Glu Ala Asp Val Thr Cys Ser Val Ser Phe Val Pro
         755                 760                 765            
 Val Asp Gly Cys Thr Cys Pro Ala Gly Thr Phe Leu Asn Asp Ala Gly
     770                 775                 780                
 Ala Cys Val Pro Ala Gln Lys Cys Pro Cys Tyr Ala His Gly Thr Val
 785                 790                 795                 800
 Leu Ala Pro Gly Glu Val Val His Asp Glu Gly Ala Val Cys Ser Cys
                 805                 810                 815    
 Thr Gly Gly Lys Leu Ser Cys Leu Gly Ala Ser Leu Gln Lys Ser Thr
             820                 825                 830        
 Gly Cys Ala Ala Pro Met Val Tyr Leu Asp Cys Ser Asn Ser Ser Ala
         835                 840                 845            
 Gly Thr Pro Gly Ala Glu Cys Leu Arg Ser Cys His Thr Leu Asp Val
     850                 855                 860                
 Gly Cys Phe Ser Thr His Cys Val Ser Gly Cys Val Cys Pro Pro Gly
 865                 870                 875                 880
 Leu Val Ser Asp Gly Ser Gly Gly Cys Ile Ala Glu Glu Asp Cys Pro
                 885                 890                 895    
 Cys Val His Asn Glu Ala Thr Tyr Lys Pro Gly Glu Thr Ile Arg Val
             900                 905                 910        
 Asp Cys Asn Thr Cys Thr Cys Arg Asn Arg Arg Trp Glu Cys Ser His
         915                 920                 925            
 Arg Leu Cys Leu Gly Thr Cys Val Ala Tyr Gly Asp Gly His Phe Ile
     930                 935                 940                
 Thr Phe Asp Gly Asp Arg Tyr Ser Phe Glu Gly Ser Cys Glu Tyr Ile
 945                 950                 955                 960
 Leu Ala Gln Asp Tyr Cys Gly Asp Asn Thr Thr His Gly Thr Phe Arg
                 965                 970                 975    
 Ile Val Thr Glu Asn Ile Pro Cys Gly Thr Thr Gly Thr Thr Cys Ser
             980                 985                 990        
 Lys Ala Ile Lys Leu Phe Val Glu Ser Tyr Glu Leu Ile Leu Gln Glu
         995                1000                1005            
 Gly Thr Phe Lys Ala Val Ala Arg Gly Pro Gly Gly Asp Pro Pro Tyr
    1010                1015                1020                
 Lys Ile Arg Tyr Met Gly Ile Phe Leu Val Ile Glu Thr His Gly Met
1025                1030                1035                1040
 Ala Val Ser Trp Asp Arg Lys Thr Ser Val Phe Ile Arg Leu His Gln
                1045                1050                1055    
 Asp Tyr Lys Gly Arg Val Cys Gly Leu Cys Gly Asn Phe Asp Asp Asn
            1060                1065                1070        
 Ala Ile Asn Asp Phe Ala Thr Arg Ser Arg Ser Val Val Gly Asp Ala
        1075                1080                1085            
 Leu Glu Phe Gly Asn Ser Trp Lys Leu Ser Pro Ser Cys Pro Asp Ala
    1090                1095                1100                
 Leu Ala Pro Lys Asp Pro Cys Thr Ala Asn Pro Phe Arg Lys Ser Trp
1105                1110                1115                1120
 Ala Gln Lys Gln Cys Ser Ile Leu His Gly Pro Thr Phe Ala Ala Cys
                1125                1130                1135    
 Arg Ser Gln Val Asp Ser Thr Lys Tyr Tyr Glu Ala Cys Val Asn Asp
            1140                1145                1150        
 Ala Cys Ala Cys Asp Ser Gly Gly Asp Cys Glu Cys Phe Cys Thr Ala
        1155                1160                1165            
 Val Ala Ala Tyr Ala Gln Ala Cys His Asp Ala Gly Leu Cys Val Ser
    1170                1175                1180                
 Trp Arg Thr Pro Asp Thr Cys Pro Leu Phe Cys Asp Phe Tyr Asn Pro
1185                1190                1195                1200
 His Gly Gly Cys Glu Trp His Tyr Gln Pro Cys Gly Ala Pro Cys Leu
                1205                1210                1215    
 Lys Thr Cys Arg Asn Pro Ser Gly His Cys Leu Val Asp Leu Pro Gly
            1220                1225                1230        
 Leu Glu Gly Cys Tyr Pro Lys Cys Pro Pro Ser Gln Pro Phe Phe Asn
        1235                1240                1245            
 Glu Asp Gln Met Lys Cys Val Ala Gln Cys Gly Cys Tyr Asp Lys Asp
    1250                1255                1260                
 Gly Asn Tyr Tyr Asp Val Gly Ala Arg Val Pro Thr Ala Glu Asn Cys
1265                1270                1275                1280
 Gln Ser Cys Asn Cys Thr Pro Ser Gly Ile Gln Cys Ala His Ser Leu
                1285                1290                1295    
 Glu Ala Cys Thr Cys Thr Tyr Glu Asp Arg Thr Tyr Ser Tyr Gln Asp
            1300                1305                1310        
 Val Ile Tyr Asn Thr Thr Asp Gly Leu Gly Ala Cys Leu Ile Ala Ile
        1315                1320                1325            
 Cys Gly Ser Asn Gly Thr Ile Ile Arg Lys Ala Val Ala Cys Pro Gly
    1330                1335                1340                
 Thr Pro Ala Thr Thr Pro Phe Thr Phe Thr Thr Ala Trp Val Pro His
1345                1350                1355                1360
 Ser Thr Thr Ser
                



      <210> 184
      <211> 1296
      <212> PRT
      <213> Homo sapiens


      <400> 184
 Met Ser Thr Ser Asp Ile Pro Ser Ser Pro Ser Ile Gln Asn Thr Glu
   1               5                  10                  15    
 Thr Ser Ser Leu Val Ser Met Thr Ser Ala Thr Ile Pro Ser Val Arg
              20                  25                  30        
 Pro Thr Phe Thr Ser Thr His Asn Thr Leu Thr Ser Ser Leu Leu Thr
          35                  40                  45            
 Thr Phe Pro Gly Thr Tyr Ser Phe Ser Ser Ser Met Ser Ala Ser Ser
      50                  55                  60                
 Asp Gly Thr Thr His Thr Glu Thr Ile Thr Ser Leu Pro Ala Ser Thr
  65                  70                  75                  80
 Ser Thr Leu His Thr Thr Ala Glu Ser Thr Thr Ala His Thr Thr Thr
                  85                  90                  95    
 Thr Ser Phe Thr Thr Ser Thr Thr Met Glu Ser Pro Ser Ser Ser Val
             100                 105                 110        
 Ala Thr Thr Ser Thr Gly Gln Thr Thr Phe Ser Ser Ser Thr Ala Thr
         115                 120                 125            
 Phe Thr Glu Thr Thr Thr Leu Thr Pro Thr Thr Asp Phe Ser Glu Glu
     130                 135                 140                
 Thr Leu Thr Thr Ala Met Thr Ser Thr Pro Pro Ile Thr Ser Ser Ile
 145                 150                 155                 160
 Thr Pro Thr Asn Thr Val Thr Ser Met Thr Thr Met Thr Ser Trp Pro
                 165                 170                 175    
 Thr Ala Thr Asn Thr Leu Ser Ser Leu Thr Thr Asn Ile Leu Ser Ser
             180                 185                 190        
 Thr Pro Val Pro Ser Thr Glu Arg Thr Thr Ser His Thr Thr Asn Ile
         195                 200                 205            
 Asn Pro Val Ser Thr Leu Val Thr Thr Leu Pro Thr Thr Ile Thr Arg
     210                 215                 220                
 Ser Thr Pro Thr Ser Glu Thr Thr Tyr Pro Ile Ser Ser Thr Ser Thr
 225                 230                 235                 240
 Val Thr Glu Ser Thr Thr Glu Ile Thr Tyr Ser Thr Thr Met Thr Glu
                 245                 250                 255    
 Thr Ser Ser Ser Ala Thr Ser Leu Pro Leu Thr Ser Pro Leu Val Ser
             260                 265                 270        
 Thr Thr Glu Thr Ala Lys Thr Pro Thr Thr Ile Leu Val Thr Thr Thr
         275                 280                 285            
 Thr Lys Thr Thr Ser His Ser Thr Thr Ser Phe Thr Ser Ser Thr Val
     290                 295                 300                
 Tyr Ser Thr Ala Ser Thr His Thr Thr Ala Ile Thr Ser Val Pro Thr
 305                 310                 315                 320
 Thr Leu Gly Thr Met Val Thr Ser Thr Ser Arg Ile Pro Ser Thr Val
                 325                 330                 335    
 Ser Thr Ser Ile Pro Thr Ser Gln Pro Lys Thr Val Asn Ser Ser Ser
             340                 345                 350        
 Gly Gly Ile Thr Gly Ser Leu Pro Met Met Thr Asp Leu Thr Ser Gly
         355                 360                 365            
 Tyr Thr Val Ser Ser Met Ser Ala Ile Pro Thr Thr Val Ile Pro Thr
     370                 375                 380                
 Ser Leu Thr Val Gln Asn Thr Glu Thr Ser Ile Phe Val Ser Met Thr
 385                 390                 395                 400
 Ser Ala Thr Thr Pro Ser Gly Arg Pro Thr Phe Thr Ser Thr Val Asn
                 405                 410                 415    
 Thr Pro Thr Arg Ser Leu Leu Thr Ser Phe Pro Thr Thr His Leu Phe
             420                 425                 430        
 Ser Ser Ser Met Ser Glu Ser Ser Ala Gly Thr Thr His Thr Glu Ser
         435                 440                 445            
 Ile Ser Ser Pro Pro Ala Thr Thr Ser Thr Leu His Thr Thr Ala Glu
     450                 455                 460                
 Ser Thr Pro Ser Cys Thr Thr Thr Thr Ser Phe Ile Thr Ser Thr Thr
 465                 470                 475                 480
 Met Glu Pro Leu Ser Thr Ile Val Ala Thr Thr Gly Thr Val Lys Thr
                 485                 490                 495    
 Thr Val Thr Ser Ser Thr Ala Thr Phe Arg Glu Thr Thr Thr Leu Thr
             500                 505                 510        
 Ser Thr Thr Asp Ile Ser Thr Glu Ser Leu Met Thr Ala Met Thr Ser
         515                 520                 525            
 Thr Thr Arg Leu Thr Ser Ala Ile Thr Ser Lys Thr Thr Leu Thr Ser
     530                 535                 540                
 Leu Lys Thr Thr Ala Ser Arg Pro Thr Ala Asn Ser Thr Leu Ser Ser
 545                 550                 555                 560
 Leu Thr Ser Ser Ile Leu Ser Ser Thr Leu Val Pro Ser Thr Asp Met
                 565                 570                 575    
 Ile Thr Ser His Thr Thr Asn Leu Thr Arg Ser Ser Pro Leu Leu Ala
             580                 585                 590        
 Thr Leu Pro Thr Thr Ile Thr Arg Ser Thr Pro Thr Ser Glu Thr Thr
         595                 600                 605            
 Tyr Pro Thr Ser Pro Thr Ser Thr Val Lys Gly Ser Thr Thr Ser Ile
     610                 615                 620                
 Arg Tyr Ser Thr Ser Met Thr Gly Thr Leu Ser Met Glu Thr Ser Leu
 625                 630                 635                 640
 Pro Pro Thr Ser Ser Ser Leu Pro Thr Thr Glu Thr Ala Thr Met Thr
                 645                 650                 655    
 Pro Thr Thr Thr Leu Ile Thr Thr Thr Pro Asn Thr Thr Ser His Ser
             660                 665                 670        
 Thr Pro Ser Phe Thr Ser Ser Thr Ile Tyr Ser Thr Val Ser Thr Ser
         675                 680                 685            
 Thr Thr Ala Ile Thr Ser His Phe Thr Thr Ser Glu Thr Ala Val Thr
     690                 695                 700                
 Pro Thr Pro Val Thr Pro Ser Ser Leu Ser Thr Asp Ile Pro Thr Thr
 705                 710                 715                 720
 Ser Leu Arg Thr Leu Thr Pro Ser Ser Val Gly Thr Ser Thr Ser Leu
                 725                 730                 735    
 Thr Thr Thr Thr Asp Phe Pro Ser Ile Pro Thr Asp Ile Ser Thr Leu
             740                 745                 750        
 Pro Thr Arg Thr His Ile Ile Ser Ser Ser Pro Ser Ile Gln Ser Thr
         755                 760                 765            
 Glu Thr Ser Ser Leu Val Gly Thr Thr Ser Pro Thr Met Ser Thr Val
     770                 775                 780                
 Arg Met Thr Leu Arg Ile Thr Glu Asn Thr Pro Ile Ser Ser Phe Ser
 785                 790                 795                 800
 Thr Ser Ile Val Val Ile Pro Glu Thr Pro Thr Gln Thr Pro Pro Val
                 805                 810                 815    
 Leu Thr Ser Ala Thr Gly Thr Gln Thr Ser Pro Ala Pro Thr Thr Val
             820                 825                 830        
 Thr Phe Gly Ser Thr Asp Ser Ser Thr Ser Thr Leu His Thr Leu Thr
         835                 840                 845            
 Pro Ser Thr Ala Leu Ser Thr Ile Val Ser Thr Ser Gln Val Pro Ile
     850                 855                 860                
 Pro Ser Thr His Ser Ser Thr Leu Gln Thr Thr Pro Ser Thr Pro Ser
 865                 870                 875                 880
 Leu Gln Thr Ser Leu Thr Ser Thr Ser Glu Phe Thr Thr Glu Ser Phe
                 885                 890                 895    
 Thr Arg Gly Ser Thr Ser Thr Asn Ala Ile Leu Thr Ser Phe Ser Thr
             900                 905                 910        
 Ile Ile Trp Ser Ser Thr Pro Thr Ile Ile Met Ser Ser Ser Pro Ser
         915                 920                 925            
 Ser Ala Ser Ile Thr Pro Val Phe Ser Thr Thr Ile His Ser Val Pro
     930                 935                 940                
 Ser Ser Pro Tyr Ile Phe Ser Thr Glu Asn Val Gly Ser Ala Ser Ile
 945                 950                 955                 960
 Thr Gly Phe Pro Ser Leu Ser Ser Ser Ala Thr Thr Ser Thr Ser Ser
                 965                 970                 975    
 Thr Ser Ser Ser Leu Thr Thr Ala Leu Thr Glu Ile Thr Pro Phe Ser
             980                 985                 990        
 Tyr Ile Ser Leu Pro Ser Thr Thr Pro Cys Pro Gly Thr Ile Thr Ile
         995                1000                1005            
 Thr Ile Val Pro Ala Ser Pro Thr Asp Pro Cys Val Glu Met Asp Pro
    1010                1015                1020                
 Ser Thr Glu Ala Thr Ser Pro Pro Thr Thr Pro Leu Thr Val Phe Pro
1025                1030                1035                1040
 Phe Thr Thr Glu Met Val Thr Cys Pro Thr Ser Ile Ser Ile Gln Thr
                1045                1050                1055    
 Thr Leu Thr Thr Tyr Met Asp Thr Ser Ser Met Met Pro Glu Ser Glu
            1060                1065                1070        
 Ser Ser Ile Ser Pro Asn Ala Ser Ser Ser Thr Gly Thr Gly Thr Val
        1075                1080                1085            
 Pro Thr Asn Thr Val Phe Thr Ser Thr Arg Leu Pro Thr Ser Glu Thr
    1090                1095                1100                
 Trp Leu Ser Asn Ser Ser Val Ile Pro Leu Pro Leu Pro Gly Val Ser
1105                1110                1115                1120
 Thr Ile Pro Leu Thr Met Lys Pro Ser Ser Ser Leu Pro Thr Ile Leu
                1125                1130                1135    
 Arg Thr Ser Ser Lys Ser Thr His Pro Ser Pro Pro Thr Thr Arg Thr
            1140                1145                1150        
 Ser Glu Thr Pro Val Ala Thr Thr Gln Thr Pro Thr Thr Leu Thr Ser
        1155                1160                1165            
 Arg Arg Thr Thr Arg Ile Thr Ser Gln Met Thr Thr Gln Ser Thr Leu
    1170                1175                1180                
 Thr Thr Thr Ala Gly Thr Cys Asp Asn Gly Gly Thr Trp Glu Gln Gly
1185                1190                1195                1200
 Gln Cys Ala Cys Leu Pro Gly Phe Ser Gly Asp Arg Cys Gln Leu Gln
                1205                1210                1215    
 Thr Arg Cys Gln Asn Gly Gly Gln Trp Asp Gly Leu Lys Cys Gln Cys
            1220                1225                1230        
 Pro Ser Thr Phe Tyr Gly Ser Ser Cys Glu Phe Ala Val Glu Gln Val
        1235                1240                1245            
 Asp Leu Asp Ala Glu Asp Phe Cys Arg His Ala Gly Leu His Leu Gln
    1250                1255                1260                
 Gly Cys Gly Asp Pro Val Pro Glu Glu Trp Gln His Arg Gly Gly Leu
1265                1270                1275                1280
 Pro Gly Pro Ala Gly Asp Ala Leu Gln Pro Pro Ala Gly Glu Arg Val
                1285                1290                1295    





      <210> 185
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 185
 Met Leu Val Val Ile Val Gln Tyr Arg Leu Gly Ile Phe Gly Phe Phe
   1               5                  10                  15    
 Thr Thr Trp Asp Gln His Ala Pro Gly Asn Trp Ala Phe Lys Asp Gln
              20                  25                  30        
 Val Ala Ala Leu Ser Trp Val Gln Lys Asn Ile Glu Phe Phe Gly Gly
          35                  40                  45            
 Asp Pro Ser Ser Val Thr Ile Phe Asp Ser Val Ser His Gly Arg Arg
      50                  55                  60                
 Leu Ile Pro Gln Ser Arg His Gly Glu Trp Gly Gly His His Pro Leu
  65                  70                  75                  80
 Pro Glu Gly Pro
                



      <210> 186
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 186
 Met Tyr Val Leu Arg Met Ser Val Cys Ala Val Cys Ala Cys Val Cys
   1               5                  10                  15    
 Cys Val Phe Val Cys Ala Val Phe Met Cys Ala Val His Ala Cys Val
              20                  25                  30        
 Leu Cys Ala Cys Val Cys Cys Val Leu Cys Ser Cys Val Cys Cys Val
          35                  40                  45            
 Cys Met Cys Cys Val His Val Cys Ala Val Phe Val Cys Val Leu Cys
      50                  55                  60                
 Val Leu Cys Ser Cys Val Leu Cys Ser Arg Val Cys Ala Val Cys Ala
  65                  70                  75                  80
 Cys Val Cys Cys Val Phe Val Cys Val Leu Cys Ala Ser Val Leu Cys
                  85                  90                  95    
 Val His Val Cys Ala Cys Ala Val Arg Leu Cys Ala Val Cys Ser Cys
             100                 105                 110        
 Val Cys Cys Val Cys Val Cys Ala Val Arg Leu Cys Val Arg Val Arg
         115                 120                 125            
 Leu Arg Val Cys Cys Val Cys Met Cys Val Arg Val Cys Ala Val Arg
     130                 135                 140                
 Leu Cys Ala Val Cys Ala Cys Val Cys Val Cys Val Leu Cys Val Cys
 145                 150                 155                 160
 Val Cys Ala Val Cys Ser Ser Val Cys Cys Val Cys Cys Ala Phe Val
                 165                 170                 175    
 Cys Val Leu Tyr Ala Arg Val Cys Ala Val Leu Val Cys Val Leu Cys
             180                 185                 190        
 Ser Cys Val Cys Cys Val Leu Cys Val Cys Ser Cys Gly Asp Ala
         195                 200                 205        
